1. 1-24 of 903 1 2 3 4 ... 36 37 38 »
    1. Ocular coherence tomography‐measured changes over time in anterior chamber angle and diurnal intraocular pressure after laser iridotomy: IMPACT study

      Ocular coherence tomography‐measured changes over time in anterior chamber angle and diurnal intraocular pressure after laser iridotomy: IMPACT study

      Importance The change in the anatomical dimensions over time and the effect on diurnal intraocular pressure (DIOP) following laser peripheral iridotomy is poorly understood. Background To evaluate change over time in anterior chamber angle anatomy following laser peripheral iridotomy (LPI) in patients with primary angle closure compared to control eyes. Additionally, the effect of LPI on DIOP fluctuation was investigated. Design Longitudinal, prospective, double‐randomized research study. Participants Adults with suspected angle closure or angle closure diagnosis referred to hospital services in the United Kingdom. Methods Thirty‐nine patients newly diagnosed with bilateral primary angle closure/suspects (PAC/PACS) received ...

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    2. Optical monitoring of adipose tissue destruction under encapsulated lipase action

      Optical monitoring of adipose tissue destruction under encapsulated lipase action

      Enzymatic destruction of adipose tissue has been achieved by encapsulation of lipase into the polymeric microcapsules. Adipose tissue destruction was delayed while lipase is encapsulated comparing with the direct lipase action as demonstrated by optical microscopy and optical coherence tomography in in vitro studies. Raman spectroscopy confirms that triglycerides in fat tissue were cleaved into free fatty acids, glycerol, and possible di‐ and monoglyceride residues. The results underpin the concept of local and controlled treatment of tissues via encapsulation. Effect of lipase encapsulation into the polymeric microcapsules on adipose tissue destruction compared to free lipase

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      Mentions: Valery V. Tuchin
    3. Histologic validation of ICDAS‐II and polarization sensitive optical coherence tomography to detect smooth surface early carious lesions

      Histologic validation of ICDAS‐II and polarization sensitive optical coherence tomography to detect smooth surface early carious lesions

      Aim This in vitro study aimed to histologically validate and compare the methods for detection of smooth surface early carious lesions (ECLs) that is , International caries detection and assessment system for the smooth surface (ICDAS‐II‐SSC), Polarization sensitive optical coherence tomography (PS‐OCT), and radiography. Methodology PS‐OCT images for scores 0‐3 of ICDAS‐II‐SSC were standardized according to ECLs’ depth. Preliminary PS‐OCT images for ICDAS‐II‐SSC score‐2 of pigmented ECLs showed reduced lesion depth and therefore were dichotomized into scores 2 and 2p for white and pigmented lesions (ICDAS‐II‐SSCm). ECLs on ...

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    4. Optical coherence tomography features in brothers with aspartylglucosaminuria

      Optical coherence tomography features in brothers with aspartylglucosaminuria

      Aspartylglucosaminuria is a lysosomal storage disorder enriched in Finland. We report on a pair of non‐Finnish siblings with aspartylglucosaminuria with autofluorescent inclusion bodies on optical coherence tomography, a finding not previously reported in this disorder. We performed a record review, neurological and neuropsychological evaluation, brain MRI, and optical coherence tomography for each patient. They are compound heterozygous for a 34‐kb deletion and a c.365C>A novel variant of the AGA gene. Autofluorescent inclusion bodies were found on optical coherence tomography in the older, more severely affected brother. We hypothesize the finding represents a noninvasive biomarker of disease ...

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    5. A review of non‐invasive imaging in extramammary Paget's disease

      A review of non‐invasive imaging in extramammary Paget's disease

      Extramammary Paget's Disease (EMPD) is a rare intraepithelial adenocarcinoma that classically manifests with pruritic, erythematous and scaling plaques. The clinical picture frequently mimics inflammatory or infectious conditions and is thus commonly misdiagnosed. The assessment of tumour margins is equally challenging as tumours have a propensity to spread beyond clinically visible boundaries. Appropriate non‐invasive diagnostic tools can assist in the early detection, diagnosis and management of EMPD. This paper will review the literature on non‐invasive imaging modalities used in EMPD. Articles from the PubMed database were selected based on relevance to the topic of this review. Articles that ...

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    6. Inherited epidermolysis bullosa: description of clinical and subclinical morphological features with optical coherence tomography

      Inherited epidermolysis bullosa: description of clinical and subclinical morphological features with optical coherence tomography

      Epidermolysis bullosa (EB) is an inherited skin disorder characterized by exacerbated skin and/or mucosal fragility and blister formation following minor mechanical trauma. Great scientific interest has recently been focused on gene therapies and transgenic epidermal grafting in EB patients. 1 Depending on the level of cleavage in the skin, EB is classified into 4 types: simplex (EBS), junctional (JEB), and dystrophic (DEB), and the extremely rare Kindler syndrome

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    7. Visualisation of the visual system

      Visualisation of the visual system

      In vivo imaging techniques have had a major impact on vision science research, not least because they provide access to the entire human visual pathway from the anterior eye to higher‐level processing areas within the brain. A special issue of Ophthalmic & Physiological Optics titled ‘Imaging the visual system: from the eye to the brain’ 1 highlighted the breadth of imaging‐related research in vision science by including papers that spanned ocular surface, 2 retinal 3 and brain 4 imaging. The special issue also emphasised fundamental research questions that can be addressed with imaging. These included diurnal changes in ocular ...

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    8. Assessment of macular ganglion cell complex using optical coherence tomography: impact of a paediatric reference database in clinical practice

      Assessment of macular ganglion cell complex using optical coherence tomography: impact of a paediatric reference database in clinical practice

      Importance Optical coherence tomography software classifies abnormality of macular ganglion cell‐inner plexiform layer thickness and macular retinal nerve fibre layer thickness based on adult series. Background We assessed the impact of using paediatric reference macular ganglion cell complex values instead of adult reference values. Design Cross‐sectional study. Primary and tertiary health‐care setting. Participants Out of 140 healthy participants aged 5 to 18 years, 90% were eligible. Methods Following a dilated eye examination and cycloplegic refraction, participants underwent optical coherence tomography ganglion cell scans (Topcon 3D OCT‐2000). Right eye measurements for superior, inferior, and total layer thickness ...

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    9. In vitro flow and optical coherence tomography comparison of two bailout techniques after failed provisional stenting for bifurcation percutaneous coronary interventions

      In vitro flow and optical coherence tomography comparison of two bailout techniques after failed provisional stenting for bifurcation percutaneous coronary interventions

      Objectives To evaluate, in vitro, SB stenting techniques after failed provisional stenting. We aimed to compare flows and stent strut apposition of T and protrusion (TAP) versus Reversed String (RS) techniques using a flow simulator, optical coherence tomography (OCT) using silicon bifurcation phantoms with different bifurcation angulations. Background While bifurcation coronary artery stenoses are preferably treated with provisional T‐stenting strategy, the preferred bailout two stents technique to treat the side branch remains unclear. Methods and results Eleven 30°‐angle and ten 60°‐angle bifurcation phantoms were used. After performing provisional stenting, TAP and RS techniques were compared in six ...

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    10. A prospective, single‐center, randomized study to assess whether automated coregistration of optical coherence tomography with angiography can reduce geographic miss

      A prospective, single‐center, randomized study to assess whether automated coregistration of optical coherence tomography with angiography can reduce geographic miss

      Objective We sought to evaluate whether automated coregistration of optical coherence tomography (OCT) with angiography reduces geographic miss (GM) during coronary stenting. Background Previous intravascular ultrasound or OCT studies have showed that residual disease at the stent edge or stent edge dissection was associated with stent thrombosis or edge restenosis. This has been termed GM. Methods Two hundred de novo coronary lesions were randomized in a 1:1 ratio to OCT‐guided percutaneous coronary intervention (PCI) with versus without automated coregistration of OCT with angiography. GM, the primary endpoint, was defined as angiographic ≥type B dissection or diameter stenosis >50 ...

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    11. Superparamagnetic graphene quantum dot as a dual‐modality contrast agent for confocal fluorescence microscopy and magnetomotive optical coherence tomography

      Superparamagnetic graphene quantum dot as a dual‐modality contrast agent for confocal fluorescence microscopy and magnetomotive optical coherence tomography

      A magnetic graphene quantum dot (MGQD) nanoparticle, synthesized by hydrothermally reducing and cutting graphene oxide‐iron oxide sheet, was demonstrated to possess the capabilities of simultaneous confocal fluorescence and magnetomotive optical coherence tomography (MMOCT) imaging. This MGQD shows low toxicity, significant tunable blue fluorescence and superparamagnetism, which can thus be used as a dual‐modality contrast agent for confocal fluorescence microscopy (CFM) and MMOCT. The feasibility of applying MGQD as a tracer of cells is shown by imaging and visualizing MGQD labeled cells using CFM and our in‐house MMOCT. Since MMOCT and CFM can offer anatomical structure and intracellular ...

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    12. Effect of orbital atherectomy in calcified coronary artery lesions as assessed by optical coherence tomography

      Effect of orbital atherectomy in calcified coronary artery lesions as assessed by optical coherence tomography

      Objectives We sought to assess plaque modification and stent expansion following orbital atherectomy (OA) for calcified lesions using optical coherence tomography (OCT). Background The efficacy of OA for treating calcified lesions is not well studied, especially using intravascular imaging in vivo. Methods OCT was performed preprocedure, post‐OA, and post‐stent ( n  = 58). Calcium modification after OA was defined as a round, concave, polished calcium surface. Calcium fracture was complete discontinuity of calcium. Results Comparing pre‐ vs post‐OA OCT ( n  = 29), calcium area was significantly decreased post‐OA (from 3.4 mm 2 [2.4–4.7] to 2 ...

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      Mentions: Gary S. Mintz
    13. Retinal imaging with optical coherence tomography and low‐loss adaptive optics using a 2.8‐mm beam size

      Retinal imaging with optical coherence tomography and low‐loss adaptive optics using a 2.8‐mm beam size

      As data acquisition for retinal imaging with optical coherence tomography (OCT) becomes faster, efficient collection of photons becomes more important to maintain image quality. One approach is to use a larger aperture at the eye’s pupil to collect more photons that have been reflected from the retina. A 2.8‐mm beam diameter system with only 7 reflecting surfaces was developed for low‐loss retinal imaging. The larger beam size requires defocus and astigmatism correction, which was done in a closed loop adaptive optics method using a Shack‐Hartmann wavefront sensor and a deformable mirror with 140 actuators and ...

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    14. Automated assessment of breast cancer margin in optical coherence tomography images via pre‐trained convolutional neural network

      Automated assessment of breast cancer margin in optical coherence tomography images via pre‐trained convolutional neural network

      The benchmark method for the evaluation of breast cancers involves microscopic testing of a hematoxylin and eosin (H&E) stained tissue biopsy. Resurgery is required in 20‐30% of cases because of incomplete excision of malignant tissues. Therefore, a more accurate method is required to detect the cancer margin to avoid the risk of recurrence. In the recent years, convolutional neural networks (CNNs) has achieved excellent performance in the field of medical images diagnosis. It automatically extracts the features from the images and classifies them. In the proposed study, we apply a pre‐trained Inception‐v3 CNN with reverse active ...

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      Mentions: UCLA
    15. Dexamethasone for unresponsive diabetic macular oedema: optical coherence tomography biomarkers

      Dexamethasone for unresponsive diabetic macular oedema: optical coherence tomography biomarkers

      Purpose To analyse the effects of intravitreal dexamethasone implant (DEX) in patients with diabetic macular oedema (DME) unresponsive to ranibizumab treatment, in relation to the inflammatory optical coherence tomography (OCT) retinal features, subfoveal neuroretinal detachment (SND) and hyperreflective retinal spots (HRS). Methods Patients with DME poorly responsive to three injections of ranibizumab were treated with DEX. Best‐corrected visual acuity (BCVA) and central macula thickness (CMT, measured by Spectralis SD‐OCT) were assessed at baseline and at 1, 3, and 6 months. Results Overall, 44 eyes were included in the study. In the whole group, mean BCVA (baseline 51.5 ...

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    16. Super‐achromatic Optical Coherence Tomography Capsule for Ultrahigh‐resolution Imaging of Esophagus

      Super‐achromatic Optical Coherence Tomography Capsule for Ultrahigh‐resolution Imaging of Esophagus

      Endoscopic optical coherence tomography (OCT) is a noninvasive technology allowing for imaging of tissue microanatomies of luminal organs in real time. Conventional endoscopic OCT operates at 1,300 nm wavelength region with a sub‐optimal axial resolution limited to 8‐20 μm. In this paper we present the first ultrahigh‐resolution tethered OCT capsule operating at 800 nm and offering about 3‐4 fold improvement of axial resolution (plus enhanced imaging contrast). The capsule uses diffractive optics to manage chromatic aberration over a full ~200 nm spectral bandwidth centering around 830 nm, enabling to achieve super‐achromaticity and an axial ...

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    17. Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation

      Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation

      Purpose To evaluate changes in tear meniscus dynamics using optical coherence tomography (OCT) after the instillation of different concentrations of sodium hyaluronate (SH) ophthalmic solutions. Methods An experimental, double‐masked, randomized study was performed. Twenty‐three healthy subjects (16 women and seven men; mean age 23.57 ± 2.56 years) participated in this study. About 35 μ l of 0.1%, 0.2%, 0.3% SH ophthalmic solutions and saline solution was instilled in a randomly assigned eye. Tear meniscus measurements (height, depth and turbidity) were taken with OCT at 30 seconds and 1, 3, 5, 10 and 20 min after ...

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    18. Predicting the outcome of laser peripheral iridotomy for primary angle closure suspect eyes using anterior segment optical coherence tomography

      Predicting the outcome of laser peripheral iridotomy for primary angle closure suspect eyes using anterior segment optical coherence tomography

      Purpose Develop an algorithm to predict the success of laser peripheral iridotomy (LPI) in primary angle closure suspect (PACS), using pretreatment anterior segment optical coherence tomography (ASOCT) scans. Methods A total of 69 eyes with PACS underwent LPI and time‐domain ASOCT scans (temporal and nasal cuts) were performed before and after LPI. After LPI, success is defined as one or more angles changed from closed to open. All the pretreatment ASOCT scans were analysed using the Anterior Segment Analysis Program to derive anterior chamber angle (ACA) measurements. The measurements for each angle were ordered along with angle‐independent measurements ...

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    19. In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy

      In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy

      Neurotrophic keratopathy (NK) is a rare degenerative corneal disorder characterized by instability of epithelial integrity with consequent epithelial defects that can worsen up to persistent epithelial defects with stromal melting and ulceration. The pathogenesis of NK springs from a variable degree of damage to the trigeminal nerve plexus, leading to a reduction or total loss of corneal sensitivity. Mackie classification (1995) distinguishes three stages of NK, based on the severity of clinical presentation. The technological innovations in corneal diagnostic imaging allow clinicians to accurately study the morphometry and morphology of corneal structure with microscopic resolution. In this study, 45 patients ...

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    20. Optical coherence tomography and magnetic resonance imaging visual pathway evaluation in Wolfram syndrome

      Optical coherence tomography and magnetic resonance imaging visual pathway evaluation in Wolfram syndrome

      Aim The aim of this study was to assess parameters of retinal morphology by using high‐definition optical coherence tomography (OCT) in patients with Wolfram syndrome (WFS) and their relation to optic tract atrophy in magnetic resonance imaging (MRI). Method High‐definition OCT and MRI parameters were evaluated in 12 patients with WFS (three males, nine females; median age at examination 12y 8mo, range 10y 2mo–15y 11mo) and referred to 30 individuals with type 1 diabetes (T1D) (12 males, 18 females; median age at examination 20y 5mo, range 16y 8mo–21y 4mo) and 33 typically developing comparison participants (10 ...

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    21. Anterior segment optical coherence tomography: its application in clinical practice and experimental models of disease

      Anterior segment optical coherence tomography: its application in clinical practice and experimental models of disease

      Optical coherence tomography (OCT) provides non‐invasive, high‐resolution in vivo imaging of the ocular surface and anterior segment. Over the years, it has become an essential tool for evaluating the anterior segment of the eye to monitor ocular development and ocular pathologies in both the clinical and research fields of ophthalmology and optometry. In this review, the clinical applications relating to the use of anterior segment OCT for imaging and quantifying normal and pathological features of the ocular surface, cornea, anterior chamber, and aqueous outflow system are summarised in a range of human ocular diseases. Applications of anterior segment ...

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    1-24 of 903 1 2 3 4 ... 36 37 38 »
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