1. 1-24 of 824 1 2 3 4 ... 33 34 35 »
    1. Clinical impact of optical coherence tomography findings on culprit plaque in acute coronary syndrome: The OCT‐FORMIDABLE study registry

      Clinical impact of optical coherence tomography findings on culprit plaque in acute coronary syndrome: The OCT‐FORMIDABLE study registry

      Background Aim of this study was to evaluate the clinical impact of the culprit plaque features assessed by optical coherence tomography (OCT) in patients with acute coronary syndrome (ACS). Methods The OCT‐FORMIDABLE register enrolled retrospectively all consecutive patients who perform OCT on culprit plaque in patients with ACS in nine European centres. The primary endpoint was the prevalence of culprit plaque rupture (CPR) in patients experiencing major adverse cardiovascular events (MACEs). Secondary endpoint was the prevalence necrotic core with macrophage infiltrations (NCMI) in the patients experiencing MACEs. Results Two‐hundred and nine patients were included in the study. Mean ...

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    2. Pseudo‐Kaposi sarcoma: report of a case investigated by dermoscopy, reflectance confocal microscopy and optical coherence tomography

      Pseudo‐Kaposi sarcoma: report of a case investigated by dermoscopy, reflectance confocal microscopy and optical coherence tomography

      Letter to the editor. First described in 1965 by Mali et al., pseudo‐Kaposi sarcoma (PKS), also known as acroangiodermatitis, is a rare disease inscribed in the setting of cutaneous reactive angiomatoses (CRAs). CRA are all characterized by occlusion and/or inflammation of cutaneous vessels, followed by histiocyte recruitment and endotheliocyte and pericyte hyperplasia. As the name suggests, PKS nearly resembles Kaposi sarcoma, but is benign in its nature. PKS typically presents with violaceous papules and plaques, usually located on the inferior limbs.

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    3. Dynamic optical coherence tomography of histamine induced wheals

      Dynamic optical coherence tomography of histamine induced wheals

      Background Dynamic optical coherence tomography (D‐OCT) is a noninvasive imaging technique providing images of the skin and detecting movement in the tissue ie, measuring blood flow. The “attenuation coefficient” describes light absorption and scattering abilities of the tissue, while the dynamic signal provides a quantitative measure of the blood flow. Aim The study objective is to describe the dynamic changes of the skin and skin vessels during histamine release using D‐OCT. Methods Healthy volunteers had local histamine injections in the skin and D‐OCT‐scans performed at 2‐minute intervals to detect changes in blood flow, attenuation and ...

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    4. In situ biofilm quantification in Bioelectrochemical Systems using Optical Coherence Tomography

      In situ biofilm quantification in Bioelectrochemical Systems using Optical Coherence Tomography

      Detailed studying of microbial growth in bioelectrochemical systems is required for their proper design and operation. Here we report on the use of Optical Coherence Tomography (OCT) as a tool for in situ and non‐invasive quantification of biofilm growth on electrodes (bioanodes). An experimental platform is designed and described in which transparent electrodes are used to allow for real‐time, three‐dimensional biofilm imaging. The accuracy and precision of the developed method is assessed by relating OCT results to well‐established standards for biofilm quantification (COD and Total N) and show high correspondence to these standards. Biofilm thickness as ...

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    5. The use of intensity‐based Doppler variance method for single vessel response to functional neurovascular activation

      The use of intensity‐based Doppler variance method for single vessel response to functional neurovascular activation

      This study presents one use of optical coherence tomography angiography (OCT) technique to examine neurovascular coupling effect. Repeated B‐scans OCT recording is performed on the rat somatosensory cortex with cranial window preparation while its contra‐lateral forepaw is electrically stimulated to activate the neurons in rest. We use an intensity‐based Doppler variance (IBDV) algorithm mapped cerebral blood vessels in the cortex, and the temporal alteration in blood perfusion during neurovascular activation is analyzed using the proposed IBDV quantitative parameters. By using principal component analysis (PCA)‐based Fuzzy C Means clustering method, the stimulus‐evoked vasomotion patterns were classified ...

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    6. Visualization of corneal vascularization in peripheral hypertrophic subepithelial corneal opacification with OCT angiography

      Visualization of corneal vascularization in peripheral hypertrophic subepithelial corneal opacification with OCT angiography

      Purpose The major goal of this study was to test the hypothesis that in patients with peripheral hypertrophic subepithelial corneal opacification (PHSCO), visualization of corneal vessels is better with optical coherence tomography angiography (OCTA) than with conventional slit lamp microphotography. Methods Patients with PHSCO were included in this prospective study. The corneal findings were photographed using a slit lamp camera (Haag Streit BM 900 ® ) and visualized with anterior‐segment OCT (Optovue XR Avanti, Fremont, California, USA). Additionally, OCTA with the Angiovue Imaging™ System was performed in the area of PHSCO. Results Thirty‐four eyes of 19 patients (26% male and ...

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      Mentions: Optovue Haag-Streit
    7. Spectrally encoded coherence tomography and reflectometry: Simultaneous en face and cross‐sectional imaging at 2 gigapixels per second

      Spectrally encoded coherence tomography and reflectometry: Simultaneous en face and cross‐sectional imaging at 2 gigapixels per second

      Non‐invasive biological imaging is crucial for understanding in vivo structure and function. Optical coherence tomography (OCT) and reflectance confocal microscopy are two of the most widely used optical modalities for exogenous contrast‐free, high‐resolution, three‐dimensional imaging in non‐fluorescent scattering tissues. However, sample motion remains a critical barrier to raster‐scanned acquisition and reconstruction of wide‐field anatomically accurate volumetric datasets. We introduce spectrally encoded coherence tomography and reflectometry (SECTR), a high‐speed, multimodality system for simultaneous OCT and spectrally encoded reflectance (SER) imaging. SECTR utilizes a robust system design consisting of shared optical relays, scanning mirrors ...

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    8. Cerebral capillary flow imaging by wavelength‐division‐multiplexing swept‐source optical Doppler tomography

      Cerebral capillary flow imaging by wavelength‐division‐multiplexing swept‐source optical Doppler tomography

      Swept‐source optical coherence tomography has demonstrated the unique advantages for fast imaging rate and long imaging distance, however, limited axial resolution and complex phase noises restrict swept‐source optical coherence Doppler tomography (SS‐ODT) for quantitative capillary blood flow imaging in the deep cortices. Here, the wavelength‐division‐multiplexing optical Doppler tomography (WDM‐ODT) method, which divides a single interferogram into multiple phase‐correlated interferograms, is proposed to effectively enhance the sensitivity for cerebral capillary flow imaging. Both flow phantom and in vivo mouse brain imaging studies show that WDM‐ODT is able to significantly suppress background phase noise ...

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    9. Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis

      Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis

      Optical coherence tomography (OCT) is an optical imaging technology that enables real time, high‐resolution, cross‐sectional and en face investigation of skin by detecting reflected broad‐spectrum near‐infrared light from tissue. OCT provides micron‐scale spatial resolution and millimeter‐scale depth of penetration [1]. Several commercial OCT systems with handheld probes targeted for Dermatology are now available [2].

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    10. Three‐months optical coherence tomography analysis of a biodegradable polymer, sirolimus‐eluting stent

      Three‐months optical coherence tomography analysis of a biodegradable polymer, sirolimus‐eluting stent

      Objective We aimed to assess early neointimal healing by optical coherence tomography (OCT) 3 months after implantation of the ultrathin Orsiro® sirolimus‐eluting stent with biodegradable polymer. Background New generations of drug‐eluting stents with biodegradable polymer have been developed to avoid the continued vascular irritation of durable polymers. Methods In this prospective, open‐label study, 34 patients received an Orsiro® sirolimus‐eluting stent with biodegradable polymer. In a subgroup of patients ( n  = 15), the intervention was performed under OCT guidance. All patients underwent OCT‐examination at three months. The primary endpoint was 3‐month neointimal healing (NIH) score, calculated ...

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    11. Evaluating glaucomatous abnormality in peripapillary optical coherence tomography enface visualisation of the retinal nerve fibre layer reflectance

      Evaluating glaucomatous abnormality in peripapillary optical coherence tomography enface visualisation of the retinal nerve fibre layer reflectance

      Purpose Optical coherence tomography (OCT) enface visualisation of the retinal nerve fibre layer (RNFL) reflectance has been found to have some advantages over retinal thickness measures. However, it is not yet clear how abnormalities on enface images relate to findings of abnormalities from other clinical measures such as the circumpapillary retinal nerve fibre layer thickness (cRNFLT). We developed a technique to analyse the RNFL reflectance on the OCT enface images, and to investigate its relation with the cRNFLT. Methods Spectralis ( www.heidelbergengineering.com ) OCT scans of the central retinal ±24° were analysed in the study eye of 31 controls and ...

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    12. OCT image atlas of healthy skin on sun‐exposed areas - O'Leary - - Skin Research and Technology - Wiley Online Library

      OCT image atlas of healthy skin on sun‐exposed areas - O'Leary - - Skin Research and Technology - Wiley Online Library

      Background Skin cancer represents the most prevalent type of cancer in the United States. Excision of these lesions can leave significant scarring, and a delay in the diagnosis of malignant melanoma could result in metastasis or death. Therefore, developing technology and criteria to accurately diagnose these cancers is of particular importance to the medical community. While biopsy can lead to scarring and infections, dermoscopy and confocal microscopy offer noninvasive imaging methods but are also limited in their ability to determine tumor depth and margins. Optical coherence tomography (OCT) is a promising imaging method that uses near‐infrared light backscattering to ...

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    13. Evaluation of two‐dimensional Bruch's membrane opening minimum rim area for glaucoma diagnostics in a large patient cohort

      Evaluation of two‐dimensional Bruch's membrane opening minimum rim area for glaucoma diagnostics in a large patient cohort

      Purpose To characterize the two‐dimensional parameter Bruch's membrane opening minimum rim area (BMO‐MRA) in spectral domain optical coherence tomography (SD‐OCT) of the optic nerve head (ONH) compared to minimum rim width (BMO‐MRW) and retinal nerve fibre layer (RNFL) thickness in a large patient cohort. Methods Case–control, cross‐sectional study of 705 eyes of 445 participants. A total of 449 eyes with glaucoma, 67 eyes with ocular hypertension and 189 healthy controls, underwent SD‐OCT and confocal laser scanning tomography (CSLT), visual field testing and clinical examination. Morphometric ONH parameters, visual field function and diagnostic ...

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    14. Ocular microcirculation measurement with laser speckle flowgraphy and optical coherence tomography angiography in glaucoma

      Ocular microcirculation measurement with laser speckle flowgraphy and optical coherence tomography angiography in glaucoma

      Purpose To compare glaucoma severity with ocular microcirculation, measured with either laser speckle flowgraphy (LSFG) or optical coherence tomography angiography (OCTA). Methods We retrospectively studied 82 eyes of 82 open‐angle glaucoma (OAG) patients who underwent same‐day LSFG and OCTA examinations, with 20 eyes of 20 healthy subjects as controls. In OCTA images, vessel density (VD) (%) was calculated in concentric regions (regions 1, 2 and 3: R1, R2 and R3, respectively) defined by 1.6‐, 3.2‐ and 3.6‐mm‐diameter circles around the optic nerve head (ONH). In R3, the large vessels were automatically masked to calculate ...

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    15. Reflectance confocal microscopy and optical coherence tomography for the diagnosis of bullous pemphigoid and pemphigus and surrounding subclinical lesions

      Reflectance confocal microscopy and optical coherence tomography for the diagnosis of bullous pemphigoid and pemphigus and surrounding subclinical lesions

      Background Diagnosis of bullous pemphigoid (BP) and pemphigus is based on clinical features, histology, immunofluorescence and laboratory data. Objectives To evaluate features of BP and pemphigus at reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) in order to provide a rapid non‐invasive bed‐side diagnosis. Secondary objective was to evaluate the detectability of clinically non‐visible lesions. Methods This was an observational, retrospective, multicentre study in which patients with suspicious lesions for BP or pemphigus underwent clinical assessment, RCM, OCT, blood tests and skin biopsy for histological and direct immunofluorescence examinations from January 2014 to December 2015. A ...

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    16. Angiographic optical coherence tomography imaging of hemangiomas and port wine birthmarks

      Angiographic optical coherence tomography imaging of hemangiomas and port wine birthmarks

      Objectives A current therapeutic challenge of vascular lesions is that they do not always respond effectively to laser treatment. Information on targeted vessels could potentially be used to guide laser treatments. Optical coherence tomography (OCT) is a useful tool for the non‐invasive imaging of tissues, including skin hemangiomas and port wine birthmarks. Dynamic OCT is able to rapidly characterize cutaneous blood vessels. The primary goal of this study was to demonstrate the ability of bedside OCT to image (i) overall vessel pattern; (ii) individual vessel morphology, diameter and depth; and (iii) total vessel density as a function of depth ...

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    17. 5-Year clinical follow-up of the COBRA (complex coronary bifurcation lesions: Randomized comparison of a strategy using a dedicated self-expanding biolimus A9-eluting stent vs. a culotte strategy using everolimus-eluting stents) study

      5-Year clinical follow-up of the COBRA (complex coronary bifurcation lesions: Randomized comparison of a strategy using a dedicated self-expanding biolimus A9-eluting stent vs. a culotte strategy using everolimus-eluting stents) study

      Objectives We evaluated healing responses with optical coherence tomography, and long-term clinical outcomes after treatment with a dedicated stent versus a conventional culotte technique. Background Dedicated bifurcation stents have been proposed as an alternative treatment for coronary bifurcation lesions. The long-term performance of dedicated stents versus conventional dual-stent techniques for the treatment of complex coronary bifurcation lesions is unknown. Methods Forty patients with true coronary bifurcation lesions were randomized to treatment with a dedicated Axxess bifurcation stent in the proximal main vessel and additional Biomatrix stents in branches versus culotte stenting using Xience stents. Results The percentage of uncovered struts ...

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    18. Bilateral retinoschisis in a dog: A veterinary clinical application for optical coherence tomography

      Bilateral retinoschisis in a dog: A veterinary clinical application for optical coherence tomography

      A 11-year-old neutered male Labrador retriever-cross dog was presented to the University of Missouri-Columbia Veterinary Ophthalmology Service for subtle visual deficits. Indirect ophthalmoscopy revealed a smooth, bullous elevation in the superior-temporal retina OU. Optical coherence tomography (OCT) performed OU showed inner retinal separation consistent with retinoschisis. Electroretinography (ERG) revealed markedly reduced b-wave amplitudes in the more severely affected eye (OD) compared with the less severely affected eye (OS). The most notable reductions were in the rod response and 30-Hz flicker b-waves OD which were approximately 50% of the corresponding amplitudes OS. Implicit times, particularly the a-wave implicit times, were noticeably ...

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    19. Differences in rotational positioning and subsequent distal main branch rewiring of the Tryton stent: An optical coherence tomography and computational study

      Differences in rotational positioning and subsequent distal main branch rewiring of the Tryton stent: An optical coherence tomography and computational study

      Objectives To evaluate the occurrence of rewiring through one of the panels of the Tryton stent (instead of the assumed re-wiring in-between the panels) and the influence on stent geometry and mechanics. Background Tryton is a side branch stent used in combination with a main branch device. It is placed without the need of rotational orientation. However, it is unknown whether main branch re-wiring accidentally may occur through a panel, instead of in-between the panels. Methods We used three-dimensional optical coherence tomography to evaluate the location of distal main branch re-wiring through Tryton. Furthermore, we used computer simulations to evaluate ...

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    20. In vivo optical coherence tomography imaging in a case of mucous membrane pemphigoid and a negative Nikolsky's sign

      In vivo optical coherence tomography imaging in a case of mucous membrane pemphigoid and a negative Nikolsky's sign

      There is currently a growing interest in new diagnostic tools of the oral cavity and mucosa which are non-invasive, repeatable and reliable. A diagnosis of a suspected, autoimmune pathology was made regarding a 57-year-old patient with desquamative gingivitis. However, a negative Nikolsky's sign did not seem to indicate a diagnosis of mucous membrane pemphigoid neither was there any indication as to the optimum location for an incisional biopsy. As an imaging method, the use of optical coherence tomography (OCT) has enabled the obtaining of tomographic (cross-sectional) scans of tissue. Such images are acquired prior to and after verifying Nikolsky ...

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    21. Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity

      Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity

      Purpose To investigate flow area changes measured using optical coherence tomography angiography (OCTA; RTVue XR Avanti ® ) in patients with retinitis pigmentosa (RP) with preserved visual acuity (VA). Methods This was an age- and refraction-matched case–control study. Consecutive patients with a best-corrected visual acuity (BCVA) of ≥20/20 and normal subjects were recruited. Fifty eyes (32 patients) and 22 eyes (12 controls) were included. The flow area and foveal avascular zone (FAZ) were measured in both superficial and deep layers within a 3 × 3 mm central area of the fovea. Association between OCTA parameters and the length of the inner ...

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    22. In vivo characterization of pustules in Malassezia Folliculitis by reflectance confocal microscopy and optical coherence tomography. A case series study

      In vivo characterization of pustules in Malassezia Folliculitis by reflectance confocal microscopy and optical coherence tomography. A case series study

      Background and objective Malassezia Folliculitis (MaF) is an inflammatory condition of hair follicles caused by Malassezia yeast. Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) are imaging technologies enabling in vivo visualization of superficial skin layers. This study explores morphology of pustules in MaF imaged by OCT and RCM. Methods Patients with microscopically verified MaF were included in this case series. Morphology was evaluated qualitatively with RCM and OCT, focusing on shape, border and content of selected pustules. Results Nine patients with MaF were included. Clinically, six patients presented monomorphic MaF with multiple superficial pustules, while three patients showed ...

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