1. 25-48 of 889 « 1 2 3 4 5 ... 35 36 37 »
    1. Structure versus function in high myopia using optical coherence tomography and automated perimetry

      Structure versus function in high myopia using optical coherence tomography and automated perimetry

      Background To examine the structure–function relationship between retinal thickness using spectral‐domain optical coherence tomography and standard automated perimetry in high myopia. Methods The study population comprised 58 highly myopic individuals with no posterior abnormalities (mean spherical equivalent refraction ≤ −6.00 D and axial length ≥ 26.0 mm). All eyes underwent optical coherence tomography with the Spectralis spectral domain optical coherence tomograph and visual field evaluation with the Humphrey Field Analyzer II‐ i . Average macular layer thicknesses in each quadrant were calculated in a 6 × 6 mm area centred on the fovea. The visual field was assessed from 17 ...

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    2. Optical coherence tomography evaluation of the optic nerve head neuro‐retinal rim in glaucoma

      Optical coherence tomography evaluation of the optic nerve head neuro‐retinal rim in glaucoma

      Clinical examination of the optic disc is a fundamental component of any ophthalmic evaluation, but it is especially important for diagnosis and management of glaucoma. The purpose of this article is to: (1) review the limitations inherent to clinical examination; (2) outline the rationale for adopting into clinical practice quantitative measures of the optic nerve head neuro‐retinal rim tissue integrity derived from current optical coherence tomography imaging approaches; (3) describe recent developments in this area; and (4) highlight a few avenues of active research that hold promise for future translation to clinical practice.

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    3. Hemi‐macular detachment: EnFace optical coherence tomography characteristics and clinical implications

      Hemi‐macular detachment: EnFace optical coherence tomography characteristics and clinical implications

      Letter to the editor: The results of this study have not been published or presented elsewhere. The study was carried out according to the 1964 Helsinki declaration and has been approved by the national research committee (Ethical Committee of Canton Vaud, Switzerland, protocol no 483/14). Informed consent was obtained from all study participants.

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    4. Corneal tomographic features of post‐refractive surgery ectasia

      Corneal tomographic features of post‐refractive surgery ectasia

      he purpose of this study was to evaluate tomographic features of post‐refractive surgery eyes. This was a retrospective evaluation of clinical data. Three patients with post‐LASIK and 2 patients with post‐SMILE ectasia were imaged with Scheimpflug imaging (SI, Pentacam) and optical coherence tomography (OCT, RTVue). Curvature and wavefront aberrations of the air‐epithelium interface (A‐E) and Epithelium‐Bowman’s layer interface (E‐B) were derived. OCT tomography of normal and keratoconic eyes from an earlier study were compared with the data of the ectasia eyes. Curvature and aberrometry of the A‐E interfaces were statistically similar ...

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      Mentions: Rohit Shetty
    5. Optical coherence tomography angiography analysis of macular flow density in glaucoma

      Optical coherence tomography angiography analysis of macular flow density in glaucoma

      Purpose Modifications in ocular blood flow may play a significant role in glaucoma development. Optical coherence tomography angiography (OCT‐A) is based on the detection and analysis of the reflection behaviour of motion in a static environment and therefore is able to quantify the retinal flow density. We used this new technology to examine the density of the active flow vasculature in the macular area in glaucoma patients compared to healthy patients. Methods Thirty patients with primary open‐angle glaucoma (mean age: 72.6 ± 7.1 years) and 21 healthy patients (mean age: 70.3 ± 8.6 years) were recruited ...

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      Mentions: Carsten Framme
    6. Distribution of scleral thickness and associated factors in 810 Chinese children and adolescents: a swept‐source optical coherence tomography study

      Distribution of scleral thickness and associated factors in 810 Chinese children and adolescents: a swept‐source optical coherence tomography study

      Purpose To explore the subfoveal thickness of sclera (SST), choroid (SCT) and retina (SRT) as well as their relationship in healthy Chinese children with varying levels of refractive error. Methods A total of 810 healthy Chinese schoolchildren and adolescents underwent a series of comprehensive ocular examinations, as well as swept‐source optical coherence tomography (OCT) after induced cycloplegia. The thicknesses of the sclera, choroid and retina below the central fovea were measured manually, and each measurement was compared across different refractive statuses. Independent factors associated with the thickness of each layer were analysed. Results The mean SST, SCT and SRT ...

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    7. Retinal imaging including OCT angiography for detecting active choroidal neovascularization in pseudoxanthoma elasticum

      Retinal imaging including OCT angiography for detecting active choroidal neovascularization in pseudoxanthoma elasticum

      Importance The diagnostic accuracy of different retinal imaging modalities to detect active choroidal neovascularization (CNV) in pseudoxanthoma elasticum (PXE) is essential to enable a correct diagnosis but currently poorly understood. Background Optical coherence tomography (OCT), fluorescein angiography (FA) and optical coherence tomography angiography (OCT‐A) are employed in daily practice but a systematic comparison of these imaging techniques is lacking. Design Retrospective, observational study. Participants Twenty patients (31 eyes) with PXE. Methods OCT, FA and OCT‐A imaging was performed in each eye and graded separately by independent readers. Main Outcome Measures Diagnostic accuracy, sensitivity and specificity to detect CNVs ...

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    8. Longitudinal bleb morphology in anterior segment OCT after minimally invasive transscleral ab interno Glaucoma Gel Microstent implantation

      Longitudinal bleb morphology in anterior segment OCT after minimally invasive transscleral ab interno Glaucoma Gel Microstent implantation

      Purpose Like the classic trabeculectomy, the minimally invasive, ab interno XEN Glaucoma Gel Microstent (XEN‐GGM) creates a filtration bleb in the conjunctiva. The goal of this study was to investigate internal bleb morphology over time with anterior segment optical coherence tomography (AS‐OCT) after XEN‐GGM implantation. Methods In a prospective, single‐centre, single‐armed cohort study, blebs were characterized using AS‐OCT in 78 eyes of 60 patients at day 1, at weeks 1 and 2 and at months 1, 3, 6, 9 and 12 after XEN‐GGM implantation in patients with open‐angle glaucoma. Morphological bleb characteristics ...

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    9. Intraocular robotic interventional surgical system (IRISS): Semi‐automated OCT‐guided cataract removal

      Intraocular robotic interventional surgical system (IRISS): Semi‐automated OCT‐guided cataract removal

      Background With the development of laser‐assisted platforms, the outcomes of cataract surgery have been improved by automating several procedures. The cataract‐extraction step continues to be manually performed, but due to deficiencies in sensing capabilities, surgical complications such as posterior capsule rupture and incomplete cataract removal remain. Methods An optical coherence tomography (OCT) system is integrated into our intraocular robotic interventional surgical system (IRISS) robot. The OCT images are used for preoperative planning and intraoperative intervention in a series of automated procedures. Real‐time intervention allows surgeons to evaluate the progress and override the operation. Results The developed system ...

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    10. Evaluation of retinal morphology of canine sudden acquired retinal degeneration syndrome using optical coherence tomography and fluorescein angiography

      Evaluation of retinal morphology of canine sudden acquired retinal degeneration syndrome using optical coherence tomography and fluorescein angiography

      Purpose To describe the optical coherence tomography (OCT) and fluorescein angiography changes in dogs with sudden acquired retinal degeneration syndrome (SARDS). Methods Retinal OCT was performed on 10 SARDS dogs and eight control dogs. Tomograms were collected in four quadrants around the optic nerve. Measurements were collected from the photoreceptor layer, the outer nuclear layer, the outer retina, the inner retina and the whole retina thickness in all quadrants. Sodium fluorescein was injected intravenously and serial fundic photographs were collected for a 5 minute period post‐injection. Results In all quadrants, the outer nuclear layer (dorsal temporal P = 0.0000 ...

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    11. Optical coherence tomography in acute optic neuritis: A population‐based study

      Optical coherence tomography in acute optic neuritis: A population‐based study

      Objectives To measure early structural damage caused by autoimmune inflammatory optic neuritis (ON) by optical coherence tomography (OCT) in a population‐based cohort. Methods In a prospective population‐based study over 24 months in Southern Denmark, patients diagnosed with acute ON and without prior diagnosis of a chronic neuroinflammatory disorder were included and examined with OCT, visual evoked potentials (VEP), visual fields, high contrast visual acuity (HCVA), and low contrast letter acuity (LCLA). Structural and functional outcomes were determined at 6‐month follow‐up based on interocular differences. Results The 50 included patients had on average 16.9 μm peripapillary ...

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    12. A compact high‐speed full‐field optical coherence microscope for high‐resolution in vivo skin imaging

      A compact high‐speed full‐field optical coherence microscope for high‐resolution in vivo skin imaging

      A compact high‐speed full‐field optical coherence microscope has been developed for high‐resolution in vivo imaging of biological tissues. The interferometer, in the Linnik configuration, has a size of 11×11×5 cm 3 and a weight of 210 g. Full‐field illumination with low‐coherence light is achieved with a high‐brightness broadband light‐emitting diode. High‐speed full‐field detection is achieved by using part of the image sensor of a high‐dynamic range CMOS camera. En face tomographic images are acquired at a rate of 50 Hz, with an integration time of 0.9 ms ...

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    13. A non‐invasive imaging and measurement using optical coherence tomography angiography for the assessment of gingiva: An in vivo study

      A non‐invasive imaging and measurement using optical coherence tomography angiography for the assessment of gingiva: An in vivo study

      Gingiva is the soft tissue that surrounds and protects the teeth. Healthy gingiva provides an effective barrier to periodontal insults to deeper tissue, thus is an important indicator to a patient’s periodontal health. Current methods in assessing gingival tissue health, including visual observation and physical examination with probing on the gingiva, are qualitative and subjective. They may become cumbersome when more complex cases are involved, such as variations in gingival biotypes where feature and thickness of the gingiva are considered. A non‐invasive imaging technique providing depth‐resolved structural and vascular information is necessary for an improved assessment of ...

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    14. Optical coherence tomography and molecular analysis of sudden acquired retinal degeneration syndrome (SARDS) eyes suggests the immune‐mediated nature of retinal damage

      Optical coherence tomography and molecular analysis of sudden acquired retinal degeneration syndrome (SARDS) eyes suggests the immune‐mediated nature of retinal damage

      Objective To perform detailed analysis of retinal changes in dogs with SARDS using optical coherence tomography (OCT), funduscopy, and molecular analysis. Animals Subjects were 29 dogs from 12 US states and Canada diagnosed with SARDS by 8 ophthalmologists. An additional 7 eyes from 5 deceased SARDS dogs were used for molecular and histological analysis. Procedures Dogs were evaluated using chromatic pupil light reflex testing (cPLR), and electroretinography (ERG); subjects underwent complete ophthalmic examination, including funduscopy, retinal photography, and OCT, in addition to complete laboratory analysis, blood pressure evaluation, abdominal and thoracic radiographs, and computerized tomography (CT) imaging to assess possible ...

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    15. Precision percutaneous coronary intervention: Is optical coherence tomography co‐registration the future?

      Precision percutaneous coronary intervention: Is optical coherence tomography co‐registration the future?

      Integration of angiographic co‐registration (ACR) with optical coherence tomography (OCT) leads to significant changes in PCI strategy. ACR with OCT allows complete integration of all available data‐points to aid decision making. Randomized clinical trials comprehensively evaluating the impact of OCT with ACR to improve clinical outcomes are ongoing.

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    16. Feasibility study of using the dispersion of surface acoustic wave (SAW) impulse for viscoelasticity characterization in tissue mimicking phantoms

      Feasibility study of using the dispersion of surface acoustic wave (SAW) impulse for viscoelasticity characterization in tissue mimicking phantoms

      The aim of this study was to investigate the feasibility of utilizing the phase velocity dispersion of impulse surface acoustic wave (SAW) for viscoelasticity characterization of soft materials. The focused ultrasound transducer and the phase sensitive optical coherence tomography (PhS‐OCT) were applied as the impulse SAW inducer and tracker respectively. Three types of liquid‐paraffin‐based cream‐in‐agar phantoms were tested. Phase velocity dispersion curve was extracted using a Fourier transform based phase velocity analysis algorithm. Viscoelastic parameters were obtained by fitting the dispersion curve of SAW into Rayleigh wave dispersion equation. The estimated viscoelasticity was compared with ...

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    17. Acne vulgaris severity graded by in vivo reflectance confocal microscopy and optical coherence tomography

      Acne vulgaris severity graded by in vivo reflectance confocal microscopy and optical coherence tomography

      Introduction Acne is an inflammatory disease of the pilosebaceous unit, which can be investigated in vivo using reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). Objectives By means of RCM and OCT to identify morphological characteristics of acne that may be associated with clinical acne severity. Methods Patients with mild to moderate facial acne ( n  = 14, Investigators Global Assessment scale, IGA 1–3), and healthy participants ( n  = 7, IGA 0) were included in this explorative study. A total of 108 RCM image blocks and 54 OCT scans (each RCM and OCT image measuring 6 × 6 mm) were captured from ...

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      Mentions: Mette Mogensen
    18. Swept‐source optical coherence tomography angiography features of subretinal fibrosis in neovascular age‐related macular degeneration

      Swept‐source optical coherence tomography angiography features of subretinal fibrosis in neovascular age‐related macular degeneration

      Importance The study highlights the role of Optical Coherence Angiography in the management of patients with neovascular age‐related macular degeneration who have developed subretinal fibrosis. Background Development of subretinal fibrosis in the context of neovascular age‐related macular degeneration is known to adversely affect visual function. The aim of this study is to assess structure and flow features obtained through swept‐source optical coherence tomography angiography in patients with subretinal fibrosis and associate these with visual acuity. Design Institutional retrospective cohort study Participants 39 eyes of 39 patients with neovascular age‐related macular degeneration with subretinal fibrosis imaged with ...

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    19. Optical coherence tomography and scleral contact lenses: clinical and research applications

      Optical coherence tomography and scleral contact lenses: clinical and research applications

      Anterior segment optical coherence tomography (OCT) provides a wealth of opportunities for modern contact lens practice. OCT imaging has numerous clinical and research applications related to the tear film, cornea, conjunctiva, sclera and ocular adnexae, in addition to soft, rigid, and hybrid contact lenses. This review summarises the potential use of OCT imaging in modern scleral contact lens practice including initial lens selection, assessing the scleral contact lens fit with respect to the cornea and sclera, and accurately quantifying the ocular response to lens wear. Recent advances in the understanding of anterior segment metrics including scleral thickness, curvature, toricity, and ...

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    20. 1.7 micron optical coherence tomography for vaginal tissue characterization in vivo

      1.7 micron optical coherence tomography for vaginal tissue characterization in vivo

      Objectives Optical coherence tomography (OCT) can noninvasively visualize in vivo tissue microstructure with high spatial resolution that approaches the histologic level. Currently, OCT studies in gynecology are few and limited to a conventional 1.3 μm center wavelength swept light source which provides high spatial resolution but limited penetration depth. Here, we present a novel endoscopic OCT system with improved penetration depth and high resolution. Methods A novel endoscopic OCT system was developed based on a 1.7 µm swept source laser, which is capable of deeper tissue penetration due to its longer wavelength. To evaluate the performance of system ...

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    21. Optical palpation for the visualization of tumor in human breast tissue

      Optical palpation for the visualization of tumor in human breast tissue

      Accurate and effective removal of tumor in one operation is an important goal of breast‐conserving surgery. However, it is not always achieved. Surgeons often utilize manual palpation to assess the surgical margin and/or the breast cavity. Manual palpation, however, is subjective and has relatively low‐resolution. Here, we investigate a tactile imaging technique, optical palpation, for the visualization of tumor. Optical palpation generates maps of the stress at the surface of tissue under static preload compression. Stress is evaluated by measuring the deformation of a contacting thin compliant layer with known mechanical properties using optical coherence tomography. In ...

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    22. Upper airway reconstruction using long‐range optical coherence tomography: Effects of airway curvature on airflow resistance

      Upper airway reconstruction using long‐range optical coherence tomography: Effects of airway curvature on airflow resistance

      Objectives Adenotonsillectomy (AT) is commonly used to treat upper airway obstruction in children, but selection of patients who will benefit most from AT is challenging. The need for diagnostic evaluation tools without sedation, radiation, or high costs has motivated the development of long‐range optical coherence tomography (LR‐OCT), providing real‐time cross‐sectional airway imaging during endoscopy. Since the endoscope channel location is not tracked in conventional LR‐OCT, airway curvature must be estimated and may affect predicted airway resistance. The study objective was to assess effects of three realistic airway curvatures on predicted airway resistance using computational fluid ...

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    23. Subtle changes in diabetic retinas localised in 3D using OCT

      Subtle changes in diabetic retinas localised in 3D using OCT

      Purpose To detect and localise subtle changes in retinas of diabetic patients who clinically have no diabetic retinopathy (DR) or non‐proliferative DR (NPDR) as compared to age‐ and sex‐ matched controls. Spectral Domain Optical Coherence Tomography (SD‐OCT) and software to examine all retinal layers, including deeper layers, were used to quantify foveal avascular zone size and inner and outer retinal layer thicknesses, as well as to detect axial location of prominent lesions. Methods Diabetic subjects, 19 total with 16 having no DR and three having non‐proliferative retinopathy, were matched with 19 controls with respect to age and ...

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    24. Impact and trends of intravascular imaging in diagnostic coronary angiography and percutaneous coronary intervention in inpatients in the United States

      Impact and trends of intravascular imaging in diagnostic coronary angiography and percutaneous coronary intervention in inpatients in the United States

      Background Intravascular imaging with intravascular ultrasound (IVUS) and optical coherence tomography (OCT) is an important adjunct to invasive coronary angiography. Objectives The primary objective was to examine the frequency of intravascular coronary imaging, trends in imaging use, and outcomes of patients undergoing angiography and/or percutaneous coronary intervention (PCI) in the United States. Methods Adult patients ≥18 years of age undergoing in‐hospital cardiac catheterization from January 2004 to December 2014 were identified from the National Inpatient Sample (NIS). International Classification of Diseases, Ninth Revision (ICD‐9) diagnosis and procedure codes were used to identify IVUS and OCT use during ...

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    25-48 of 889 « 1 2 3 4 5 ... 35 36 37 »
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