Spatial distribution of superficial blood vessels in human skin in vivo has been observed by using the double correlation Optical Coherence Tomography (OCT). To remove background noise, reduce the artifacts associated with patient motions and to increase the overall quality of the experimental OCT images an adaptive Wiener filtering technique has been employed. Fourier domain correlation has been subsequently applied to enhance spatial resolution of images of vascular network in human skin in vivo . Image processing has been performed on Graphics Processing Units (GPUs) utilizing Compute Unified Device Architecture (CUDA) framework in the frequency-domain. This approach allows carrying out image ...

A 25-year-old woman was diagnosed with anaemic retinopathy following Plasmodium falciparum malaria. The serial clinical and spectral domain optical coherence tomography (SD-OCT) changes are described, including sub-internal limiting membrane (sub-ILM) haemorrhage at the macula with the formation of a corresponding sub-ILM cavity evident on SD-OCT. The patient was managed conservatively and showed complete recovery of fundus and SD-OCT changes after one year. To the best of our knowledge, this is the first documentation of formation of a temporary sub-ILM cavity following anaemic retinopathy

Purpose: To compare axonal loss in ganglion cells detected with spectral-domain optical coherence tomography (OCT) in eyes of patients with multiple sclerosis (MS) versus healthy control subjects using an artificial neural network (ANN). To analyse the capability of the ANN technique to improve the detection of retinal nerve fibre layer (RNFL) damage in patients with multiple sclerosis. Methods: Patients with multiple sclerosis (n = 106) and age-matched healthy subjects (n = 115) were enrolled. The Spectralis OCT system was used to obtain the circumpapillary RNFL thickness in both eyes. The 768 RNFL thickness measurements provided by the Spectralis OCT were performed to ...

Background The aim was to evaluate changes in choroidal thickness, intraocular pressure (IOP) and other parameters of optical coherence tomography, such as central foveal thickness (CFT), macular volume, peripapillary retinal nerve fibre layer (RNFL) thickness after haemodialysis (HD). Methods Thirty-four eyes of 34 chronic renal failure patients (9 eyes with diabetic patients) who underwent haemodialysis in the Dialysis Unit of Gangneung Asan Hospital were included. CFT, macular volume, peripapillary RNFL and choroidal thickness were measured before and after haemodialysis by optical coherence tomography (OCT, Spectralis; Heidelberg Engineering). Changes in the IOP were evaluated with Goldmann applanation tonometry before and after ...

We propose the use of correlation mapping optical coherence tomography (cmOCT) to deliver additional biometrics associated with the finger that could complement existing fingerprint technology for law enforcement applications. The current study extends the existing fingerprint paradigm by measuring additional biometrics associated with sub-surface finger tissue such as sub-surface fingerprints, sweat glands, and the pattern of the capillary bed to yield a user-friendly cost effective and anti-spoof multi-mode biometric solution associated with the finger. To our knowledge no other method has been able to capture sub-surface fingerprint, papillary pattern and horizontal vessel pattern in a single scan or to show ...

Left main dissection (LMD) is a rare but feared complication of cardiac catheterization. It is usually managed by bail-out stent implantation or coronary artery by-pass surgery. We describe a case of iatrogenic, retrograde LMD during percutaneous coronary intervention. After covering the retrograde entry of the dissection in the ostial LAD, optical coherence tomography (OCT) showed, that there was no antegrade entry in the left main and that the minimal true lumen area in the left main was 7.2 mm 2 . It was therefore decided to treat the LMD conservatively and reassess the results by angiography six months later. At ...

Optical coherence tomography (OCT) has long been used as a diagnostic tool in the field of ophthalmology. The ability to observe microstructural changes in the tissues of the eye has proved very effective in diagnosing ocular disease. However, this technology has yet to be introduced into the primary care office, where indications of disease are first encountered. We have developed a portable, handheld imaging probe for use in the primary care setting and evaluated its tissue site accessibility, ability to observe diseased tissue, and screening capabilities in in vivo human patients, particularly for pathologies related to the eye, ear and ...

Background The propose of this study was to analyze the relationship between retinal nerve fibre layer (RNFL) thickness measured by spectral domain optical coherence tomography and confocal scanning laser ophthalmoscope. Design Prospective, cross-sectional study. Hospital setting. Participants One hundred seventy-three subjects (85 glaucoma and 88 normal subjects). Methods One eye from each individual was selected randomly for RNFLT imaging by the spectral domain Cirrus OCT and HRT3. Main Outcome Measures Global RNFL thickness and measurements at the four quadrants around the optic disc were analyzed and compared for differences, agreement of the categorical classification, diagnostic sensitivities and specificities and the ...

Purpose: To compare the relationships of parapapillary retinal nerve fibre layer (RNFL) thickness among three spectral-domain optical coherence tomography (SD-OCT) instruments with visual field sensitivity (VFS). Methods: One hundred and thirteen eyes of 113 Japanese subjects with glaucoma (mean deviation in standard automated perimetry = −8.9 ± 6.7 dB) were imaged by Cirrus, RTVue and 3D OCT. The average hemi-superior and hemi-inferior RNFL thicknesses were obtained. In addition, the structure–function relationship using two retinotopic maps that consisted of six or nine sectors was also evaluated. Decibel (dB) scale and 1/Lamert (1/L) were used to express VFS. RNFL ...

Background and purpose In recent years a possible non-motor involvement of the nervous system in amyotrophic lateral sclerosis (ALS) has come into the focus of research and has been investigated by numerous techniques. Optical coherence tomography (OCT) – with its potential to reveal neuroaxonal retinal damage – may be an appropriate tool to investigate whether the anterior visual pathway is involved. Our aim was to determine whether OCT-based measures of retinal nerve fiber layer, ganglion cell layer, inner nuclear layer and outer nuclear layer thickness are abnormal in ALS, or correlated with disease severity. Methods Seventy-six ALS patients (144 eyes) and 54 ...

Background/purpose A number of studies of the internal structure of Japanese woman's skin are now performed by means of optical coherence tomography (OCT) as a technique capable of visualizing the internal structure in a non-invasive manner. Methods We measured the epidermal and corneous thicknesses at 11 sites in 116 healthy female volunteers aged from teens to sixties to examine possible positional differences and aging changes. Results The epidermal thickness determined at the 11 sites averaged 68.6 ± 23.0 μm (mean ± SD) and the corneous thickness averaged 14.1 ± 1.80 μm, the values of which were thinner ...

Background Optical coherence tomography is being used increasingly for corneal measurements. The current study compared corneal thickness and corneal elevation using SS-OCT (Casia, Tomey, Nagoya, Japan) and slit scanning topography (Orbscan IIz, Bausch & Lomb, Rochester, New York). Design Prospective study Participants 41 normal and 46 keratoconus subjects Methods All eyes were imaged using SS-OCT and slit scanning tomography during the same visit. Mean central (CCT) and thinnest (TCT) corneal thickness and best-fit sphere (BFS) measurements were compared between the instruments. Corneal thickness was also measured with ultrasound pachymetry (USP). Main outcome measures Agreement of measurements between SS-OCT and scanning slit ...

Background The retinal nerve fibre layer (RNFL) thickness is reportedly decreased in myopia; however, magnification adjustment is an important consideration when using optical coherence tomography (OCT) to evaluate myopic eyes. In this study, RNFL thickness and optic nerve head (ONH) size were measured in highly myopic eyes with and without magnification adjustments. The measurements were compared with magnification-adjusted OCT measurements of emmetropic control eyes. Methods In this cross-sectional study, RNFL thickness (global circle and quadrants) and ONH size (disc and rim areas) were measured in one eye of each of 70 participants with high myopia. Magnification-adjusted measurements taken in the ...

Optical coherence tomography (OCT) is a non-invasive, tomographic imaging technique which generates high-resolution in-vivo images up to mid-dermal layers. Due to continuous technological improvements, OCT is moving from research projects into daily dermatological practice. It can complement other imaging methods like high-frequency ultrasound or confocal microscopy. There is a wide variety of indications for OCT. In addition to aiding in the diagnosis and clinical monitoring of inflammatory dermatoses, OCT is a very useful and feasible technique in dermato-oncology.

Purpose:  To examine retinal and choroidal blood vessels using spectral-domain optical coherence tomography (SD-OCT). Methods:  Retrospective case series. Results:  Scans through retinal blood vessels in healthy subjects demonstrated vessel wall reflexes and a tri-layer profile of the blood column on longitudinal scans and a figure-of-eight configuration on cross-sectional scans. Intravascular reflectivity decreased with increasingly oblique angles of observation and was absent when blood flow was parallel to the line of sight. The high blood flow in the choroidal vessels in healthy subjects and the low flow in the retinal vessels in patients with ocular ischaemic syndrome and central retinal artery ...

Purpose:  To examine retinal and choroidal blood vessels using spectral-domain optical coherence tomography (SD-OCT). Methods:  Retrospective case series. Results:  Scans through retinal blood vessels in healthy subjects demonstrated vessel wall reflexes and a tri-layer profile of the blood column on longitudinal scans and a figure-of-eight configuration on cross-sectional scans. Intravascular reflectivity decreased with increasingly oblique angles of observation and was absent when blood flow was parallel to the line of sight. The high blood flow in the choroidal vessels in healthy subjects and the low flow in the retinal vessels in patients with ocular ischaemic syndrome and central retinal artery ...

Optical coherence tomography (OCT) was used to monitor various flexor tendon states including tendon at rest, normal tendons during loading, tendon microstructural damage post loading, and healing tendons at 0, 3, and 8 weeks time points.Potential uses include assessing microstructural damage, monitoring the quality of suture repair, and tendon healing.

Objective To document central corneal thickness (CCT) and power measurements in pigmented and white rabbits using Visante anterior segment optical coherence tomography (AS-OCT) and the Humphrey ATLAS Corneal Topography System (HACTS). Animal studied Fourteen female rabbits (seven pigmented and seven white rabbits) were involved in this study. Procedure Twenty-eight eyes underwent AS-OCT and HACTS examination. Central corneal thickness, corneal power in the steepest and flattest meridians, astigmatism, pupil diameter (PD), and white-to-white (WTW) were calculated. Results The CCT was 390 ± 14.2 and 373 ± 7.2 μm for pigmented and white rabbits, respectively. The CCT values showed statistical difference between ...

The aim of this study was to determine the diagnostic accuracy of swept-source optical coherent tomography (SS-OCT) in detecting and estimating the depth of proximal caries in posterior teeth in vivo. SS-OCT images and bitewing radiographs were obtained from 86 proximal surfaces of 53 patients. Six examiners scored the locations according to a caries lesion depth scale (0–4) using SS-OCT and the radiographs. The results were compared with clinical observations obtained after the treatment. SS-OCT could detect the presence of proximal caries in tomograms that were synthesized based on the backscatter signal obtained from the proximal carious lesion through ...

There are rare reports of accidental macular injury caused by a laser-induced plasma flash.1,2 Here, we report a case of macular hole due to prolonged viewing of a plasma flash by a femtosecond laser that was followed with spectral domain OCT (SD-OCT). A 25-yearlevel while not wearing protective goggles. The pulsed titanium-sapphire femtosecond laser was operating at a repetition rate of 80 MHz, 0.5 mJ pulse energy, a central wavelength of 850 nm, and a pulse duration of 50 fs. The laser beam was focused by a lens with 50 cm focal length before delivery to a ...

Objective: to compare the vascular healing process between the sirolimus-eluting NEVO and the everolimus-eluting Xience stent by optical coherence tomography (OCT) at 1-year follow-up. Background: Presence of durable polymer on a drug-eluting metallic stent may be the basis of an inflammatory reaction with abnormal healing response. The NEVO stent, having a bioresorbable polymer eluted by reservoir technology, may overcome this problem. Methods: All consecutive patients, who received NEVO or Xience stent implantation between September 2010 and October 2010 in our institution, were included. Vascular healing was assessed at 1-year as percentage of uncovered struts, neointimal thickness, in-stent / stent area obstruction ...

Two patients who underwent simultaneous kissing stenting with sirolimus-eluting stents in the left main coronary artery were investigated with optical coherence tomography (OCT) at just over 1 year postoperatively. In both cases, follow-up angiogram indicated complete coverage of the new metal carina with a membranous diaphragm, yet OCT showed varying tissue-coverage patterns transitioning from stent inflow to stent outflow. These patterns included single-strut coverage, bridge-like membrane formation between more than 1 strut, and end-to-end coverage of the carina; no uncovered stent struts were detected. OCT also demonstrated mixed patterns of tissue characteristics on the metal carina, ranging from poor endothelialization ...