1. 1-24 of 468 1 2 3 4 ... 18 19 20 »
    1. The choroid and lamina cribrosa is affected in patients with Parkinson's disease: enhanced depth imaging optical coherence tomography study

      The choroid and lamina cribrosa is affected in patients with Parkinson's disease: enhanced depth imaging optical coherence tomography study

      Purpose To compare lamina cribrosa (LC) and choroidal thicknesses using enhanced depth imaging optical coherence tomography (EDI-OCT) in patients with Parkinson's disease (PD) and healthy controls. Methods A total number of 44 eyes of 22 patients with PD and 50 eyes of 25 healthy subjects were utilized in this institutional cross-sectional study. After a complete ophthalmic examination, all eyes were imaged with OCT (RTVue-100 version 5.1 Fourier-domain optical coherence tomography; Optovue Inc., Fremont, CA, USA); LC and choroidal thickness were assessed. Results The mean LC thicknesses were 209.4 ± 40.2 μm in patients with PD and 292 ...

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      Mentions: Optovue
    2. Optimal threshold of postintervention minimum stent area to predict in-stent restenosis in small coronary arteries: An optical coherence tomography analysis

      Optimal threshold of postintervention minimum stent area to predict in-stent restenosis in small coronary arteries: An optical coherence tomography analysis

      Objectives The aim of this study was to determine the best threshold of postintervention minimum stent area (MSA) assessed by optical coherence tomography (OCT) to predict long-term in-stent restenosis (ISR) for 2.5 mm-diameter everolimus-eluting stents (EES). Background Percutaneous coronary intervention (PCI) for small coronary arteries remains challenging. Stent underexpansion is a strong predictor of late ISR. Methods We performed a retrospective analysis of 69 lesions in 69 patients undergoing PCI with 2.5 mm-diameter stents using OCT for the assessment of postintervention MSA and subsequent 9-month angiographic follow-up. Results The rates of angiographic ISR and target lesion revascularization were ...

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    3. Spatiotemporal closure of fractional laser-ablated channels imaged by optical coherence tomography and reflectance confocal microscopy

      Spatiotemporal closure of fractional laser-ablated channels imaged by optical coherence tomography and reflectance confocal microscopy

      Background and Objective Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) offer high-resolution optical imaging of the skin, which may provide benefit in the context of laser-assisted drug delivery. We aimed to characterize postoperative healing of ablative fractional laser (AFXL)-induced channels and dynamics in their spatiotemporal closure using in vivo OCT and RCM techniques. Study design/Materials and Methods The inner forearm of healthy subjects ( n  = 6) was exposed to 10,600 nm fractional CO 2 laser using 5 and 25% densities, 120 μm beam diameter, 5, 15, and 25 mJ/microbeam. Treatment sites were scanned with OCT ...

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    4. Optical coherence tomography for longitudinal monitoring of vasculature in scars treated with laser fractionation - Gong - 2015 - Journal of Biophotonics - Wiley Online Library

      Optical coherence tomography for longitudinal monitoring of vasculature in scars treated with laser fractionation - Gong - 2015 - Journal of Biophotonics - Wiley Online Library

      En face optical coherence tomography vasculature images pre-treatment (top) and ˜20 weeks after the first laser treatment (bottom) of a mature burn scar. Arrows mark the same vessel pattern. This study presents the first in vivo longitudinal assessment of scar vasculature in ablative fractional laser treatment using optical coherence tomography (OCT). A method based on OCT speckle decorrelation was developed to visualize and quantify the scar vasculature over the treatment period. Through reliable co-location of the imaging field of view across multiple imaging sessions, and compensation for motion artifact, the study was able to track the same scar tissue over ...

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    5. Lymphatic response to depilation-induced inflammation in mouse ear assessed with label-free optical lymphangiography

      Lymphatic response to depilation-induced inflammation in mouse ear assessed with label-free optical lymphangiography

      Background and Objectives Optical microangiography (OMAG) is a noninvasive technique capable of imaging 3D microvasculature. OMAG-based optical lymphangiography has been developed for 3D visualization of lymphatic vessels without the need for exogenous contrast agents. In this study, we utilize the optical lymphangiography to investigate dynamic changes in lymphatic response within skin tissue to depilation-induced inflammation by using mouse ear as a simple tissue model. Materials and Methods A spectral-domain optical coherence tomography (OCT) system is used in this study to acquire volumetric images of mouse ear. The system operates under the ultrahigh-sensitive OMAG scanning protocol with five repetitions for each ...

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    6. Systematic review of optical coherence tomography usage in the diagnosis and management of basal cell carcinoma - Cheng - British Journal of Dermatology

      Systematic review of optical coherence tomography usage in the diagnosis and management of basal cell carcinoma - Cheng - British Journal of Dermatology

      Optical coherence tomography (OCT) is a non-invasive imaging tool used in-vivo, in real time for diagnosis, treatment delineation and monitoring of basal cell carcinomas (BCC) treatment. Features of BCC on OCT have been widely described and reviewed. However, the diagnostic accuracy of OCT in these various applications are unclear. We systematically reviewed the literature to assess the accuracy of OCT in diagnosis and management of BCC using the Embase and Medline databases. 179 unique references were identified in the initial search. 22 studies with 556 histologically-proven BCC were eligible. Assessment of quality of eligible studies was undertaken using the STROBE ...

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    7. Angiographic appearance of spontaneous coronary artery dissection with intramural hematoma proven on intracoronary imaging

      Angiographic appearance of spontaneous coronary artery dissection with intramural hematoma proven on intracoronary imaging

      Background The pathognomonic appearance of multiple radiolucent lumen on angiography is used to diagnose spontaneous coronary artery dissection (SCAD). However, this finding is absent in >70% of SCAD, in which case optical coherence tomography (OCT) or intravascular ultrasound (IVUS) is useful to assess arterial wall integrity. Methods We report the angiographic appearance of SCAD that were proven on intracoronary imaging with OCT or IVUS. Our angiographic classification and algorithm for SCAD diagnosis was previously reported. Patients with type 1 SCAD (multiple radiolucent lumen) do not require OCT/IVUS, whereas, it was recommended for those with suspected type 2 (diffuse stenosis ...

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    8. Comparison of swept source optical coherence tomography (SS-OCT) and spectral domain optical coherence tomography (SD-OCT) in polypoidal choroidal vasculopathy

      Comparison of swept source optical coherence tomography (SS-OCT) and spectral domain optical coherence tomography (SD-OCT) in polypoidal choroidal vasculopathy

      Background Swept source optical coherence tomography (SS-OCT, Topcon Medical System, Japan) is known to have longer wavelength than spectral domain OCT (SD-OCT, Spectralis, Heidelberg Engineering, Germany), allowing a deeper penetration into retina and choroidal layers. This objective of this study was to compare the visibility of retinal and choroidal features in polypoidal choroidal vasculopathy (PCV) using SS-OCT and SD-OCT. Design Prospective comparative observational case series in Singapore National Eye Center (SNEC) Participants There were 20 eyes (20 patients) with PCV confirmed with indocyanine green angiogram (ICGA). Methods Six pre-specified OCT parameters (presence of polyps, sharp pigment epithelial detachment (PED) peak ...

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    9. Optical coherence tomography reflects brain atrophy in MS: A four year study

      Optical coherence tomography reflects brain atrophy in MS: A four year study

      Objective : To determine whether atrophy of specific retinal layers and brain substructures are associated over time, in order to further validate the utility of optical coherence tomography (OCT) as an indicator of neuronal tissue damage in patients with multiple sclerosis (MS). Methods : Cirrus high definition OCT (including automated macular segmentation) was performed in 107 MS patients biannually (median follow-up: 46-months). Three-tesla magnetic resonance imaging brain scans (including brain-substructure volumetrics) were performed annually. Individual-specific rates of change in retinal and brain measures (estimated with linear regression) were correlated, adjusting for age, sex, disease duration, and optic neuritis (ON) history. Results : Rates ...

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    10. Measurement of ciliary beat frequency using Doppler optical coherence tomography

      Measurement of ciliary beat frequency using Doppler optical coherence tomography

      Background Measuring ciliary beat frequency (CBF) is a technical challenge and difficult to perform in vivo. Doppler optical coherence tomography (D-OCT) is a mesoscopic noncontact imaging modality that provides high-resolution tomographic images and detects micromotion simultaneously in living tissues. In this work we used D-OCT to measure CBF in ex vivo tissue as the first step toward translating this technology to clinical use. Methods Fresh ex vivo samples of rabbit tracheal mucosa were imaged using both D-OCT and phase-contrast microscopy (n = 5). The D-OCT system was designed and built to specification in our lab (1310-nm swept source vertical-cavity surface-emitting laser ...

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    11. Impact of segmentation errors and retinal blood vessels on retinal nerve fibre layer measurements using spectral-domain optical coherence tomography

      Impact of segmentation errors and retinal blood vessels on retinal nerve fibre layer measurements using spectral-domain optical coherence tomography

      Purpose To investigate the impact of retinal blood vessels and retinal nerve fibre layer (RNFL) segmentation errors on RNFL measurement. Methods One eye of 180 subjects (60 normal, 66 mild-to-moderate and 54 advanced glaucoma subjects) was randomly selected for RNFL imaging with a spectral-domain OCT. The boundaries of the RNFL detected by the instrument software were checked, and the segmentation errors were corrected by a customized computer program. The differences in average and regional RNFL thicknesses (RNFLT) before and after the correction were analysed to determine the frequency of segmentation error (defined as an absolute difference in average RNFLT >5 ...

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    12. Relationship of ocular and systemic factors to the visibility of choroidal–scleral interface using spectral domain optical coherence tomography

      Relationship of ocular and systemic factors to the visibility of choroidal–scleral interface using spectral domain optical coherence tomography

      Purpose To assess the visibility of the choroidal–scleral interface (CSI) from spectral domain optical coherence tomography (SD-OCT) and evaluate the ocular and systemic factors influencing the visibility of CSI in healthy eyes from population-based Malay sample. Methods Participants were consecutively recruited from the population-based Singapore Malay Eye Study-2 (SiMES-2). SD-OCT images were obtained by Spectralis OCT with enhanced depth imaging (EDI) mode. Visibility of CSI was assessed by a grading system ranging from 0 to 2 scores. The reliability of choroidal thickness measurement in different grades of CSI visibility was assessed using intraclass correlation coefficient. Ordinal regression analyses were ...

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    13. Effects of rigid contact lenses on optical coherence tomographic parameters in eyes with keratoconus

      Effects of rigid contact lenses on optical coherence tomographic parameters in eyes with keratoconus

      Background The aim was to evaluate the effect of irregular astigmatism on the retinal nerve fibre layer (RNFL), macular thickness and ganglion cell analysis obtained by spectral domain optical coherence tomography (OCT) in eyes with keratoconus. Methods Fifty-two eyes of 31 patients (20 females) with keratoconus that required correction of irregular astigmatism with rigid gas-permeable (RGP) contact lenses were included to this study. The average, superior, nasal, inferior, temporal and 12 clock hour sector's RNFL, ganglion cell and macular thickness analyses before and 30 minutes after RGP contact lens (Rose K2 -Menicon Z material, David Thomas Contact Lenses Ltd ...

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    14. Rapid fabrication system for three-dimensional tissues using cell sheet engineering and centrifugation

      Rapid fabrication system for three-dimensional tissues using cell sheet engineering and centrifugation

      Three-dimensional (3-D) tissues can be reconstructed by cell sheet technology, and various clinical researches using these constructed tissues have already been initiated to regenerate damaged tissues. While 3-D tissues can be easily fabricated by layering cell sheets, the attachment period for cell adhesion between a cell sheet and a culture dish, or double-layered cell sheets normally takes 20-30 min. This study proposed a more rapid fabrication system for bioengineered tissue using cell sheet technology and centrifugation. A C2C12 mouse myoblast sheet harvested from a temperature-responsive culture dish will attach tightly to a culture dish or another cell sheet at 37 ...

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    15. Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage

      Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage

      Optical clearing is an effective method to reduce light scattering of biological tissues that provides significant enhancement of light penetration into the biological tissues making non-invasive diagnosis more feasible. In current report Optical Coherence Tomography (OCT) in conjunction with optical clearing is applied for assessment of deep cartilage layers and cartilage-bone interface. The solution of Iohexol in water has been used as an optical clearing agent. The cartilage-bone boundary becomes visible after 15 min of optical clearing that enabling non-invasive estimation of its roughness: S a = 10 ± 1 µm. The results show that for 0.9 mm thick cartilage optical ...

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    16. Detection of retinal changes in idiopathic Parkinson's disease using high-resolution optical coherence tomography and heidelberg retina tomography

      Detection of retinal changes in idiopathic Parkinson's disease using high-resolution optical coherence tomography and heidelberg retina tomography

      Purpose The study was performed to analyse the retina of patients with Parkinson's disease (PD) for morphological changes compared to healthy controls (HC) using spectral-domain optical coherence tomography (SD-OCT) and confocal scanning laser ophthalmoscopy. Methods We enrolled 108 patients with idiopathic PD and 165 HC. All study participants underwent an ophthalmological examination to exclude ophthalmological disorder potentially interfering with the retinal analyses. Peripapillary retinal nerve fibre layer (RNFL) thickness and macular thickness and volume were measured by a SD-OCT device (Heidelberg Spectralis ® ). Stereometric parameters of the optic disc were acquired by Heidelberg Retina Tomograph (HRT III). Results The RNFL ...

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    17. Scanning laser polarimetry and spectral domain optical coherence tomography for the detection of retinal changes in Parkinson's disease

      Scanning laser polarimetry and spectral domain optical coherence tomography for the detection of retinal changes in Parkinson's disease

      Purpose Whether retinal degeneration is part of the degenerative processes in patients with Parkinson's disease (PD) is still unclear. This cross-sectional study was undertaken to compare the retinal morphology of patients with PD and healthy controls using spectral domain optical coherence tomography (SD-OCT) and scanning laser polarimetry (SLP). Methods Both eyes of patients with PD ( n = 108) and healthy controls ( n = 165) were examined using SD-OCT and SLP on the same day. Data on the thickness of the retinal nerve fibre layer (RNFL) of all quadrants and the macular area were acquired by OCT (Cirrus, Zeiss). The SLP device ...

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    18. Skin substitute-assisted repair shows reduced dermal fibrosis in acute human wounds validated simultaneously by histology and optical coherence tomography

      Skin substitute-assisted repair shows reduced dermal fibrosis in acute human wounds validated simultaneously by histology and optical coherence tomography

      Skin substitutes are heterogeneous biomaterials designed to accelerate wound healing through provision of replacement extracellular matrix. Despite growing evidence for their use in chronic wounds, the role of skin substitutes in acute wound management and their influence upon fibrogenesis remains unclear. Skin substitute characteristics including biocompatibility, porosity and elasticity strongly influence cellular behaviour during wound healing. Thus, we hypothesise that structural and biomechanical variation between biomaterials may induce differential scar formation after cutaneous injury. The following human prospective cohort study was designed to investigate this premise. Four 5mm full-thickness punch biopsies were harvested from fifty volunteers. In all cases, site ...

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    19. In-Line Monitoring of a Pharmaceutical Pan Coating Process by Optical Coherence Tomography

      In-Line Monitoring of a Pharmaceutical Pan Coating Process by Optical Coherence Tomography

      This work demonstrates a new in-line measurement technique for monitoring the coating growth of randomly moving tablets in a pan coating process. In-line quality control is performed by an optical coherence tomography (OCT) sensor allowing nondestructive and contact-free acquisition of cross-section images of film coatings in real time. The coating thickness can be determined directly from these OCT images and no chemometric calibration models are required for quantification. Coating thickness measurements are extracted from the images by a fully automated algorithm. Results of the in-line measurements are validated using off-line OCT images, thickness calculations from tablet dimension measurements, and weight ...

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