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    1. Diagnosis of subglottic stenosis in a rabbit model using long-range optical coherence tomography

      Diagnosis of subglottic stenosis in a rabbit model using long-range optical coherence tomography

      Objectives/Hypothesis Current imaging modalities lack the necessary resolution to diagnose subglottic stenosis. The aim of this study was to use optical coherence tomography (OCT) to evaluate nascent subglottic mucosal injury and characterize mucosal thickness and structural changes using texture analysis in a simulated intubation rabbit model. Study Design Prospective animal study in rabbits. Methods Three-centimeter-long sections of endotracheal tubes (ETT) were endoscopically placed in the subglottis and proximal trachea of New Zealand White rabbits (n = 10) and secured via suture. OCT imaging and conventional endoscopic video was performed just prior to ETT segment placement (day 0), immediately after tube ...

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    2. In vivo endoscopic Doppler optical coherence tomography imaging of the colon

      In vivo endoscopic Doppler optical coherence tomography imaging of the colon

      Background and Objective Colorectal cancer (CRC) remains the second deadliest cancer in the United States. Several screening methods exist; however, detection of small polyps remains a challenge. Optical coherence tomography (OCT) has been demonstrated to be capable of detecting lesions as small as 1 mm in the mouse colon, but detection is based on measuring a doubling of the mucosa thickness. The colon microvasculature may be an attractive biomarker of early tumor development because tumor vessels are characterized by irregular structure and dysfunction. Our goal was to develop an endoscopic method of detecting and segmenting colon vessels using Doppler OCT ...

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    3. Markedly different tissue types on optical coherence tomography imaging in a patient with multiple lesion drug-eluting stent in-stent restenosis

      Markedly different tissue types on optical coherence tomography imaging in a patient with multiple lesion drug-eluting stent in-stent restenosis

      The treatment of in-stent restenosis after drug-eluting stent (DES) implantation remains a major clinical challenge. Optical coherence tomography (OCT) imaging at the time of presentation can provide important information on mechanical factors contributing to stent failure as well as on tissue characteristics of the in-stent neointimal tissue. We report a case of markedly different tissue types—characterized by heterogeneous and homogeneous signal intensity—observed in a patient with multiple lesion DES in-stent restenosis. Although both lesions were initially successfully treated with drug-coated balloon angioplasty, the patient presented with recurrent in-stent restenosis in the lesion with homogeneous tissue characteristics. Future studies ...

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    4. Evaluation of circumferential angle closure using iridotrabecular contact index after laser iridotomy by swept-source optical coherence tomography

      Evaluation of circumferential angle closure using iridotrabecular contact index after laser iridotomy by swept-source optical coherence tomography

      Purpose To investigate the quantitative changes of circumferential angle closure after laser iridotomy (LI) using the iridotrabecular contact (ITC) index by Swept-Source optical coherence tomography (OCT). Methods In this prospective observational study conducted in a hospital setting, 42 eyes of 36 patients (five males, 31 females) who underwent LI were included. The mean age was 65.00 ± 8.13 years old and the diagnosis included primary angle closure (PAC, 21 eyes), PAC suspect (16 eyes) and PAC glaucoma (five eyes). Optical coherence tomography (OCT) images were obtained pre-LI and at 1 week post-LI. In each image frame, the scleral spur ...

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    5. In vivo assessment of periodontal structures and measurement of gingival sulcus with Optical Coherence Tomography: a pilot study

      In vivo assessment of periodontal structures and measurement of gingival sulcus with Optical Coherence Tomography: a pilot study

      There has been increasing interest on the development of clinically acceptable, more sensitive and specific methods for non-invasive diagnosis in Periodontics. In this pilot study, the performance of an Optical Coherence Tomography (OCT) system in imaging periodontal structures in humans was evaluated. Gingival sulcus depth measurements were obtained and compared with traditional probes. In total, 445 sites of 23 periodontally healthy individuals were measured by 3 instruments: North Carolina manual probe, Florida automated probe and OCT at 1325 nm. To obtain quantitative measurements from OCT images, the gingival refractive index was also determined. Discomfort/pain perception and the duration of ...

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    6. Astigmatism corrected common path probe for optical coherence tomography

      Astigmatism corrected common path probe for optical coherence tomography

      Background and Objectives Optical coherence tomography (OCT) catheters for intraluminal imaging are subject to various artifacts due to reference-sample arm dispersion imbalances and sample arm beam astigmatism. The goal of this work was to develop a probe that minimizes such artifacts. Materials and Methods Our probe was fabricated using a single mode fiber at the tip of which a glass spacer and graded index objective lens were spliced to achieve the desired focal distance. The signal was reflected using a curved reflector to correct for astigmatism caused by the thin, protective, transparent sheath that surrounds the optics. The probe design ...

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    7. Curvature of iris profile in spectral domain optical coherence tomography and dependency to refraction, age and pupil size – the MIPH Eye&Health Study

      Curvature of iris profile in spectral domain optical coherence tomography and dependency to refraction, age and pupil size – the MIPH Eye&Health Study

      Purpose Optical coherence tomography (OCT) of the anterior segment allows quantitative analysis of the geometry of the iris. We performed spectral domain OCT examinations in healthy emmetropic, hyperopic and myopic subjects to investigate iris curvature and its associations. Methods In a cross-sectional study, out of 4617 eyes (2309 subjects) those with refractive errors of <−4 or >+3 dioptres were identified by objective refraction. The iris was examined using the anterior segment mode of a spectral domain 3D OCT-2000 (Topcon Inc., Japan) in the temporal meridian, and OCT scans were investigated with respect to presence and amount of convex and concave ...

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    8. Evaluation of posterior vitreous detachment after uneventful phacoemulsification surgery by optical coherence tomography and ultrasonography

      Evaluation of posterior vitreous detachment after uneventful phacoemulsification surgery by optical coherence tomography and ultrasonography

      Background The aim was to investigate the effect of uneventful phacoemulsification on vitreoretinal interface evaluated by optical coherence tomography (OCT) and ultrasound. Methods One hundred and fifty eyes were evaluated for the presence or absence of posterior vitreous detachment by ultrasound and OCT prior to cataract surgery. Only those eyes with intact vitreoretinal adhesion were included in the study. All patients underwent cataract surgery. At one month, three months and six months, all patients were assessed with OCT and ultrasound. The data were analysed for statistical significance. Results The study was carried out on 30 of 31 patients with no ...

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    9. Optical coherence tomography angiography versus fluorescein angiography in the diagnosis of ischaemic diabetic maculopathy

      Optical coherence tomography angiography versus fluorescein angiography in the diagnosis of ischaemic diabetic maculopathy

      Purpose To evaluate the efficacy of optical coherence tomography (OCT) angiography versus fluorescein angiography (FA) in terms of retinal vessel imaging in ischaemic diabetic maculopathy defined according to the Early Treatment Diabetic Retinopathy Study (ETDRS) classification. Methods Twenty patients (31 eyes) with ischaemic diabetic maculopathy and 17 control subjects (27 eyes) were enrolled in this prospective study. Patients and control subjects underwent complete ophthalmic examination, including best-corrected visual acuity (BCVA), intraocular pressure, FA, Fourier domain optical coherence tomography (FD-OCT) and OCT angiography. Fluorescein angiograms and OCT angiography images were graded according to the foveal avascular zone (FAZ) of the ETDRS ...

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    10. New aspect for systemic effects of copd: Eye findings

      New aspect for systemic effects of copd: Eye findings

      Introduction : Chronic Obstructive Pulmonary Disease (COPD) has multisystemic implications and comorbidities. Hypoxia and systemic inflammation are thought to involve oculary structures. In this study, our aim is to evaluate retinal nerve fiber and choroidal thickness and retinal vessel diameter using the Spectral-domain optical coherence tomography (SD-OCT) in COPD subjects. Methods : 43 subjects diagnosed with COPD according to the Chronic Obstructive Lung Disease criteria at the Pulmonology Department of Pamukkale University were enrolled in the study. All subjects underwent respiratory function testing and a carbon monoxide diffusion test. To determine hypoxic state, arterial blood gas analysis was performed. The control group ...

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    11. Basic interpretation of intracoronary ultrasound and optical coherence tomography images: examples

      Basic interpretation of intracoronary ultrasound and optical coherence tomography images: examples

      Latest advancements in intracoronary imaging have enabled the insertion of miniaturized catheters with imaging probes in coronary arteries in order to provide detailed imaging information in a cross-sectional image format after an automated pullback. Cross-sectional images can then be also used for longitudinal reconstructions for the vessel segment imaged. There are two main broadly available intracoronary imaging modalities, namely intravascular ultrasound (IVUS) and optical coherence tomography (OCT), which provide information on (1) the lumen and wall morphology as well as the anatomic and tissue characteristics of atherosclerotic plaques, and (2) endovascular implants [1, 2] . The main imaging features that are ...

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    12. Comparison between Pentacam-HR and optical coherence tomographycentral corneal thickness measurements in healthy feline eyes

      Comparison between Pentacam-HR and optical coherence tomographycentral corneal thickness measurements in healthy feline eyes

      Objectives To measure the central corneal thickness (CCT) in healthy feline eyes with Scheimpflug imaging (Pentacam, Pentacam ® -HR) and to compare these values with those obtained with spectral-domain optical coherence tomography (OCT, Optovue ® iVue). Animals studied Thirty one sedated Domestic Short-haired cats. Procedures Two repeated CCT measurements were obtained from both eyes using Pentacam measured at the pupil center and corneal apex (CCT pupil and CCT apex ) and using SD-OCT (CCT OCT ). Agreement between the imaging modalities for CCT and intradevice repeatability was evaluated with Bland–Altman analysis. Mixed modeling was used to test for a difference between methods. Results ...

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    13. A new algorithm for the discrimination of actinic keratosis from normal skin and squamous cell carcinoma based on in vivo analysis of optical properties by high-definition optical coherence tomography

      A new algorithm for the discrimination of actinic keratosis from normal skin and squamous cell carcinoma based on in vivo analysis of optical properties by high-definition optical coherence tomography

      Background High-definition optical coherence tomography (HD-OCT) features of actinic keratosis (AK) may aid in its diagnosis and therapeutic strategy. A diagnostic algorithm permitting discrimination of AK from squamous cell carcinoma (SCC) and normal skin has been proposed. However, diagnostic accuracy strongly depends on the experience of physicians. In two recent studies, it was demonstrated that HD-OCT permits to quantify in vivo optical properties such as light attenuation in intrinsic ageing skin, in melanocytic lesions and in basal cell carcinoma. This approach seems to permit a semiautomated classification of lesions easier to handle by non-experts. Objectives The aim of this paper ...

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    14. Kif14 overexpression accelerates murine retinoblastoma development

      Kif14 overexpression accelerates murine retinoblastoma development

      The mitotic kinesin KIF14 has an essential role in the recruitment of proteins required for the final stages of cytokinesis. Genomic gain and/or overexpression of KIF14 has been documented in retinoblastoma and a number of other cancers, such as breast, lung and ovarian carcinomas, strongly suggesting its role as an oncogene. Despite evidence of oncogenic properties in vitro and in xenografts, Kif14's role in tumor progression has not previously been studied in a transgenic cancer model. Using a novel Kif14 overexpressing, simian virus 40 large T-antigen retinoblastoma (TAg-RB) double transgenic mouse model, we aimed to determine Kif14 's ...

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    15. Use of new imaging in detecting and monitoring ocular manifestations of the mucopolysaccharidoses

      Use of new imaging in detecting and monitoring ocular manifestations of the mucopolysaccharidoses

      The aim of this review is to summate the eye involvement in patients with mucopolysaccharidoses (MPS) using current ocular imaging techniques, their advantages and disadvantages and how they may aid diagnosis, management and monitoring. We critically reviewed the current literature surrounding MPS and recent imaging technology as well as histology. Primary searches of PubMed and Web of Science were performed. We reviewed all papers on the topic published and summarized the findings of each medical device as well as the advantages and disadvantages of using these for the MPS patient. We discussed the potential of each of these devices to ...

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