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    1. A Comparison of Intravascular Imaging Modalities for Detection of Stent Struts in Acute Coronary Syndrome

      A Comparison of Intravascular Imaging Modalities for Detection of Stent Struts in Acute Coronary Syndrome

      Background We used optical coherence tomography (OCT) and intravascular ultrasound (IVUS) to assess the struts of implanted stents in patients with acute coronary syndrome (ACS). Methods A totle of 10,756 stent struts were analyzed with OCT in 42 patients of ACS. Of them, both of IVUS and OCT imaging were performed in 33 patients. Appearance of stent struts was classified as well apposed, buried, malapposed, and nondetectable, and the number of stent struts were counted by OCT and IVUS was compared. Results Most of stent struts were well apposed (78.1%, 8,407/10,756). However, malapposed struts were ...

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    2. Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      The diagnostic accuracy of Optical Coherence Tomography (OCT) based optical attenuation coefficient analysis is assessed for the detection of prostate cancer. Needle-based OCT-measurements were performed on the prostate specimens. Attenuation coefficients were determined by an earlier described in-house developed software package. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.56 mm –1 ; 3.85 mm –1 ; p < 0.0001) for all patients combined. The area under the ROC curve was 0.64. In order to circumvent the effect of histopathology mismatching, we performed a sub-analysis on only OCT data in which tumor ...

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    3. Use of a new intra-ocular spectral domain optical coherence tomography in vitreoretinal surgery

      Use of a new intra-ocular spectral domain optical coherence tomography in vitreoretinal surgery

      Purpose To describe the use of a novel intra-ocular side-scanning probe enabling the acquisition of spectral-domain optical coherence tomography (SD-OCT) images during surgery in a series of patients with complex forms of retinal detachment. Methods A 23-gauge, side-scanning SD-OCT probe (C7 System; LightLab Imaging, Inc/St Jude Medical, St. Paul, MN, USA) in a 20-gauge catheter, was used to acquire the intra-operative OCT images in seven patients with vitreoretinal diseases. Twenty-five gauge pars plana vitrectomy (PPV) was performed in every patient in a standard fashion. After enlarging the temporal sclerotomy to a 20-gauge port, all the patients were scanned with ...

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    4. Real-time quantitation of internal metabolic activity of three-dimensional engineered tissues using an oxygen microelectrode and optical coherence tomography

      Real-time quantitation of internal metabolic activity of three-dimensional engineered tissues using an oxygen microelectrode and optical coherence tomography

      Recent progress in tissue engineering technology has enabled us to develop thick tissue constructs that can then be transplanted in regenerative therapies. In clinical situations, it is vital that the engineered tissues to be implanted are safe and functional before use. However, there is currently a limited number of studies on real-time quality evaluation of thick living tissue constructs. Here we developed a system for quantifying the internal activities of engineered tissues, from which we can evaluate its quality in real-time. The evaluation was achieved by measuring oxygen concentration profiles made along the vertical axis and the thickness of the ...

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      Mentions: Osaka University
    5. Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer

      Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer

      Purpose To compare the diagnostic imaging ability of three different optical coherence tomography (OCT) devices in non-melanoma skin cancer (NMSC). Methods Thirty actinic keratoses (AKs) and 27 basal cell carcinomas (BCCs) of 29 patients were examined with three different OCT devices, VivoSight ® , Callisto ® and Skintell ® . Results Complete data sets were available for 16 BCCs and 10 AKs of 18 patients. All OCT devices were able to discriminate BCCs and AKs significantly from perilesional normal skin due to lower signal intensities as well as a thicker stratum corneum and epidermis in AKs. A significant decrease in the signal intensity and thickness ...

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    6. A window to beyond the orbit: the value of optical coherence tomography in non-ocular disease

      A window to beyond the orbit: the value of optical coherence tomography in non-ocular disease

      Optical coherence tomography (OCT) imaging of the eye has become an essential tool for the ophthalmologist, aiding diagnosis and assisting with treatment decisions, in many ocular diseases. However, there is an evolving role for OCT in informing on non-ocular diseases, which ophthalmologists should be aware of. The purpose of this review was to examine recent evidence for the role of ocular OCT imaging to evaluate disease beyond the orbit and to discuss possible opportunities and challenges arising from this, from the perspective of the ophthalmologist.

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      Mentions: Andrew J. Tatham
    7. Optical coherence tomography to evaluate the effects of oxidative hair dye on the fiber

      Optical coherence tomography to evaluate the effects of oxidative hair dye on the fiber

      Background/purpose Oxidative hair dyes can damage the hair, since these chemical procedures are involved to change the fiber structure and therefore changes in their mechanical and surface properties. Evaluate and compare the effect of the two colors of oxidative hair dye emulsions on Caucasian hair. This research analyzed the Dark brown hair untreated ( I ); Dark brown hair treated with light brown dye ( II ); Dark brown hair treated with light blond dye ( III ); Light blond hair untreated ( IV ); Light blond hair treated with light brown dye ( V ); Light blond hair treated with light blond dye ( VI ) on Caucasian hair. Methods ...

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    8. Classifying murine glomerulonephritis using optical coherence tomography and optical coherence elastography

      Classifying murine glomerulonephritis using optical coherence tomography and optical coherence elastography

      Elastic-wave propagation in mouse healthy and nephritic kidneys. Acute glomerulonephritis caused by antiglomerular basement membrane marked by high mortality. The primary reason for this is delayed diagnosis via blood examination, urine analysis, tissue biopsy, or ultrasound and X-ray computed tomography imaging. Blood, urine, and tissue-based diagnoses can be time consuming, while ultrasound and CT imaging have relatively low spatial resolution, with reduced sensitivity. Optical coherence tomography is a noninvasive and high-resolution imaging technique that provides superior spatial resolution (micrometer scale) as compared to ultrasound and CT. Changes in tissue properties can be detected based on the optical metrics analyzed from ...

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    9. Optical Coherence Tomography for the Detection of Remote Optic Neuritis in Multiple Sclerosis

      Optical Coherence Tomography for the Detection of Remote Optic Neuritis in Multiple Sclerosis

      BACKGROUND AND PURPOSE Evidence of remote optic neuritis is often used to support a diagnosis of multiple sclerosis (MS). Optical coherence tomography (OCT) can provide qualitative and quantitative data on the retina, where the effects of optic neuritis can be seen. Our aim was to determine whether there is a quantitative difference in retinal structures in eyes with optic neuritis compared with those without, and which measures were best able to discriminate eyes with a history of optic neuritis from nonoptic neuritis eyes in MS patients. METHODS We performed a prospective cohort study of 30 MS-optic neuritis patients, 22 MS-nonoptic ...

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      Mentions: Peter K. Kaiser
    10. Real-time imaging of anti-biofilm effects using CP-OCT

      Real-time imaging of anti-biofilm effects using CP-OCT

      The objective of this study was to develop a method to reliably and reproducibly assess the physical properties of in vitro multi-species plaque derived biofilms. A custom flow cell (FC) was designed to model oral cavity shear stresses on biofilms grown on hydroxyapatite (HA) discs. A finite-element program (ANSYS 13) modeled flow velocities and wall shear stresses on the interior 3D dimensions. For the experiment, 1% chlorhexidine (CHX), 5 M urea, and a 1× phosphate-buffered saline (PBS) were flown through the FC simulating oral rinsing. Near infrared cross-polarization optical coherence tomography (CP-OCT) non-destructively imaged the fluid immersed biofilms in real ...

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      Mentions: Robert S. Jones
    11. In vivo and in situ imaging of controlled-release dissolving silk microneedles into the skin by optical coherence tomography

      In vivo and in situ imaging of controlled-release dissolving silk microneedles into the skin by optical coherence tomography

      Nowadays, transdermal drug delivery has become a hot topic with regard to delivery. Also, the percutaneous microneedle patch made of water-soluble material makes this technique one step closer to clinical application. The process of the microneedle patch penetrates and dissolves in the animal skin can directly reflect the efficiency of drug delivery. Hence, it is important to reflect the situation of microneedles dissolution and drug release by in vivo and in situ imaging in real time. This paper's purpose is to use the means of OCT (optical coherence tomography) to realize assessment of dissolving microneedles delivery efficiency in vivo ...

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    12. Near-IR image-guided laser ablation of demineralization on tooth occlusal surfaces

      Near-IR image-guided laser ablation of demineralization on tooth occlusal surfaces

      Introduction Studies have shown that reflectance images at near-IR wavelengths coincident with higher water absorption are well-suited for image-guided laser ablation of carious lesions since the contrast between sound and demineralized enamel is extremely high and interference from stains is minimized. The objective of this study was to demonstrate that near-IR reflectance images taken at a wavelength range of 1,500–1,700 nm can be used to guide a 9.3 μm CO 2 laser for the selective ablation of early demineralization on tooth occlusal surfaces. Methods The occlusal surfaces of ten sound human molars were used in this ...

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    13. Effects of Light Variation on Schwalbe's Line-based Anterior Chamber Angle Metrics Measured with Cirrus Spectral Domain Optical Coherence Tomography

      Effects of Light Variation on Schwalbe's Line-based Anterior Chamber Angle Metrics Measured with Cirrus Spectral Domain Optical Coherence Tomography

      Background Evaluate the impact of variations in ambient lighting conditions on the reproducibility/reliability of Schwalbe's Line (SL)-based anterior chamber angle (ACA) metrics using spectral domain optical coherence tomography (SD-OCT). Design Images were taken at Doheny Eye Centers-UCLA clinic, which were randomized, masked, and graded twice by dual reading center graders. Participants 25 normal/healthy participants with open-angles Methods Inferior angles were imaged using Cirrus SD-OCT under five light levels (foot-candles(fc) measured at camera-eye interface with Sper light-meter) with the instrument's Corneal Illumination function set to default level of 50(CIdef) and low 5(CIlow). Each ...

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    14. 3D printing-assisted fabrication of double-layered optical tissue phantoms for laser tattoo treatments

      3D printing-assisted fabrication of double-layered optical tissue phantoms for laser tattoo treatments

      Background and Objective Artificial skin phantoms have been developed as an alternative tissue for human skin experiments due to convenient use and easy storage. However, fabricating both thin (∼100 μm) epidermis and relatively thick dermis is often cumbersome, and most developed phantoms have hardly reflected specific human skin types. The objective of this study was to fabricate skin phantoms with 3D printing technique to emulate various human skin types (I–VI) along with the corresponding optical and mechanical properties for laser tattoo removal. Study Design/Materials and Methods Both gelatin and agar powders were mixed with coffee and TiO 2 ...

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    15. Fatal Kawasaki disease with incomplete criteria: Correlation between optical coherence tomography and pathology

      Fatal Kawasaki disease with incomplete criteria: Correlation between optical coherence tomography and pathology

      Coronary artery aneurysm is a serious complication of Kawasaki disease (KD). A 3-month-old infant presented with severe KD 27 days after onset of fever. The patient presented with shock, inferolateral ischemia on electrocardiogram and high troponin. Echocardiography showed severe myocardial dysfunction with diffuse coronary dilation and right coronary artery aneurysm. Arterial Doppler demonstrated thrombosis of aneurysmal axillary and iliac arteries. Withdrawal of support was implemented due to multi-organ failure. Post-mortem optical coherence tomography correlated with pathology. The pulmonary artery was normal on OCT and histology. Coronary arteries showed aneurysmal dilatation, with intimal hyperplasia and preserved media on OCT. Pathology confirmed ...

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    16. Preliminary study of optical coherence tomography imaging to identify microscopic extrathyroidal extension in patients with papillary thyroid carcinoma

      Preliminary study of optical coherence tomography imaging to identify microscopic extrathyroidal extension in patients with papillary thyroid carcinoma

      Background and Objectives We evaluated the feasibility of using optical coherence tomography (OCT), to identify microscopic extrathyroidal extension (mETE) in ex vivo thyroidectomy specimens of patients who underwent thyroidectomy for the treatment of papillary thyroid carcinoma (PTC). Methods A total of 170 ex vivo OCT images of the tumor, were acquired just after completion of thyroidectomy in 17 patients. The OCT images of each patient were separately evaluated by two blinded investigators, and the outcomes were compared with the histopathology reports. Results The sensitivity and specificity of mETE identification from the OCT images were 81.4% and 86.0%, respectively ...

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    17. Temporal Trends in Strut-Level Optical Coherence Tomography Evaluation of Coronary Stent Coverage

      Temporal Trends in Strut-Level Optical Coherence Tomography Evaluation of Coronary Stent Coverage

      Objectives We sought to pool data from all studies with reported strut-level data in human subjects evaluated by optical coherence tomography (OCT) surveillance and to compare the aggregate data of stent strut coverage on a longitudinal temporal timeline from initial implantation for different coronary stent subtypes. Background Delayed strut coverage following drug-eluting stent (DES) implantation is an important contributor to late stent thrombosis (LST). OCT can detect stent strut coverage. Methods We conducted a systematic search of published or presented studies reporting OCT stent strut coverage of bare-metal stents (BMS) and DES in PubMed, Embase, Web of Science, and the ...

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    18. High resolution imaging of the fibrous microstructure in bovine common carotid artery using optical polarization tractography

      High resolution imaging of the fibrous microstructure in bovine common carotid artery using optical polarization tractography

      Optical polarization tractography can visualize fiber orientation and alignment in carotid artery. The biomechanical properties of artery are primarily determined by the fibrous structures in the vessel wall. Many vascular diseases are associated with alternations in the orientation and alignment of the fibrous structure in the arterial wall. Knowledge on the structural features of the artery wall is crucial to our understanding of the biology of vascular diseases and the development of novel therapies. Optical coherence tomography (OCT) and polarization-sensitive OCT have shown great promise in imaging blood vessels due to their high resolution, fast acquisition, good imaging depth, and ...

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    19. Characterizing the lacrimal punctal region using anterior segment optical coherence tomography

      Characterizing the lacrimal punctal region using anterior segment optical coherence tomography

      Purpose Abnormalities of lacrimal punctum size and morphology probably contribute to excess tearing, with significant effects on quality-of-life for affected individuals. Our current understanding of normal punctal morphology originates from ex vivo studies, which are unlikely to capture the true nature of the living punctum. This study used enhanced depth anterior segment optical coherence tomography (OCT) to give improved characterization and understanding of lacrimal punctal structure. Methods Qualitative and quantitative assessments were performed on spectral domain OCT images collected prospectively from 40 lower puncta of 20 healthy volunteers. Results The average external lower lid punctal diameter was 0.646 mm ...

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