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    1. Optical coherence tomography in the investigation of systemic neurologic disease

      Optical coherence tomography in the investigation of systemic neurologic disease

      Optical coherence tomography (OCT) is a well‐established technique for the clinical examination, diagnosis, severity staging and monitoring of ophthalmic disorders. The application of this technology has more recently been extended beyond ophthalmic disease, whereby it has been demonstrated that OCT can serve as an ophthalmic marker for a range of systemic neurodegenerative disorders, such as Parkinson's disease, multiple sclerosis, Alzheimer's disease and diabetic peripheral neuropathy. This review will focus on the clinical utility of OCT‐derived retinal measures for the investigation of these conditions.

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    2. Future clinical applicability of optical coherence tomography angiography

      Future clinical applicability of optical coherence tomography angiography

      Optical coherence tomography angiography (OCT‐A) is an emerging technology that allows for the non‐invasive imaging of the ocular microvasculature. Despite the wealth of observations and numerous research studies illustrating the potential clinical uses of OCT‐A, this technique is currently rarely used in routine clinical settings. In this review, technical and clinical aspects of OCT‐A imaging are discussed, and the future clinical potential of OCT‐A is considered. An understanding of the basic principles and limitations of OCT‐A technology will better inform clinicians of its future potential in the diagnosis and management of ocular diseases.

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    3. Impact of image averaging on wide‐field choroidal thickness measurements using enhanced‐depth imaging optical coherence tomography

      Impact of image averaging on wide‐field choroidal thickness measurements using enhanced‐depth imaging optical coherence tomography

      Background The aim of this study was to examine the influence of B‐scan averaging on choroidal thickness using wide‐field enhanced‐depth imaging optical coherence tomography. Methods Six high‐resolution trans‐foveal horizontal enhanced‐depth imaging line scans (spanning a 60° field) were acquired consecutively from the right eye of 10 healthy adults (mean age 30 ± 5 years), with each line scan an average of 10, 20, 30, 40, 50 or 100 B‐scans, using the automated real‐time image averaging and follow‐up features of a Spectralis device. The impact of B‐scan averaging on regional measures of ...

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    4. Multifractal and Lacunarity Analyses of Microvascular Morphology in Eyes with Diabetic Retinopathy: A Projection Artifact Resolved Optical Coherence Tomography Angiography Study

      Multifractal and Lacunarity Analyses of Microvascular Morphology in Eyes with Diabetic Retinopathy: A Projection Artifact Resolved Optical Coherence Tomography Angiography Study

      Objective To evaluate the degree of microvascular impairment in diabetic retinopathy using multifractal and lacunarity analyses and to compare the diagnostic ability between traditional Euclidean measures (fovea avascular zone area and vessel density) and fractal geometric features. Methods This retrospective cross‐sectional study included a total of 143 eyes of 94 patients with different stages of diabetic retinopathy. The retinal microvasculature was imaged by projection removed optical coherence tomography angiography. We examined the degree of association between fractal metrics of the retinal microvasculature and diabetic retinopathy severity. The area under the receiver operating characteristic curve was used to estimate the ...

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    5. Relating optical coherence tomography to visual fields in glaucoma: structure–function mapping, limitations and future applications

      Relating optical coherence tomography to visual fields in glaucoma: structure–function mapping, limitations and future applications

      Combining information from optical coherence tomography (OCT) imaging and visual field testing is useful in the clinical assessment and monitoring of patients with glaucoma. Measurements of retinal nerve fibre layer thickness or neuroretinal rim width taken around the optic nerve head may be related to the visual field using a structure–function map. In this review, the structure–function mapping methods in clinical use are discussed. Typical clinical maps provide a population average, ‘one size fits all’ representation, but in recent years methods for customising structure–function maps to individual eyes have been developed and these are reviewed here. In ...

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    6. Incidence of late‐acquired stent malapposition of drug eluting stents with second generation permanent and biodegradable polymer coatings—A prospective, randomized comparison using optical coherence tomography

      Incidence of late‐acquired stent malapposition of drug eluting stents with second generation permanent and biodegradable polymer coatings—A prospective, randomized comparison using optical coherence tomography

      Objectives and Background Polymer coatings of drug‐eluting stents (DES) may induce allergic reactions and inflammation, resulting in late‐acquired stent malapposition (LASM) with the risk of stent thrombosis. This study evaluated, if biodegradable polymer (BP) reduces the incidence of LASM compared to permanent polymer (PP) after treatment with newer generation DES. Methods and Results Fifty patients with 59 lesions were randomized (2:1) to elective treatment with second generation PP‐DES ( n  = 32, 39 stents), either Everolimus‐eluting or Zotarolimus‐eluting stents, or with BP‐DES (Biolimus‐eluting stents [BES]; n  = 18, 20 stents) and underwent optical coherence tomography ...

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    7. 5‐Year clinical follow‐up of the COBRA (complex coronary bifurcation lesions: Randomized comparison of a strategy using a dedicated self‐expanding biolimus A9‐eluting stent vs. a culotte strategy using everolimus‐eluting stents) study

      5‐Year clinical follow‐up of the COBRA (complex coronary bifurcation lesions: Randomized comparison of a strategy using a dedicated self‐expanding biolimus A9‐eluting stent vs. a culotte strategy using everolimus‐eluting stents) study

      Objectives We evaluated healing responses with optical coherence tomography, and long‐term clinical outcomes after treatment with a dedicated stent versus a conventional culotte technique. Background Dedicated bifurcation stents have been proposed as an alternative treatment for coronary bifurcation lesions. The long‐term performance of dedicated stents versus conventional dual‐stent techniques for the treatment of complex coronary bifurcation lesions is unknown. Methods Forty patients with true coronary bifurcation lesions were randomized to treatment with a dedicated Axxess bifurcation stent in the proximal main vessel and additional Biomatrix stents in branches versus culotte stenting using Xience stents. Results The percentage ...

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    8. Usefulness of longitudinal reconstructed optical coherence tomography images for predicting the need for the reverse wire technique during coronary bifurcation interventions

      Usefulness of longitudinal reconstructed optical coherence tomography images for predicting the need for the reverse wire technique during coronary bifurcation interventions

      Objectives The aim is to investigate the usefulness of longitudinal reconstructed optical coherence tomography (OCT) images in selecting the reverse wire (RW) technique for inserting a guidewire into a side branch (SB). Background It is sometimes necessary to protect the SB with a guidewire to prevent SB complications in PCI for bifurcation lesions. The RW is a novel method for guidewire insertion into an extremely angulated SB when the standard antegrade wire (AW) approach is difficult. Methods This retrospective study included 46 consecutive patients who underwent OCT‐guided PCI in bifurcation lesions with significant SB stenosis. Patients were divided into ...

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    9. Correlation between morphological characteristics in spectral‐domain‐optical coherence tomography, different functional tests and a patient's subjective handicap in acute central serous chorioretinopathy

      Correlation between morphological characteristics in spectral‐domain‐optical coherence tomography, different functional tests and a patient's subjective handicap in acute central serous chorioretinopathy

      Purpose The purpose of this study was to identify quantitatively measurable morphologic optical coherence tomography (OCT) characteristics in patients with an acute episode of central serous chorioretinopathy (CSC) and evaluate their correlation to functional and psychological variables for their use in daily clinical practice. Methods Retinal thickness (RT), the height, area and volume of subretinal fluid (SRF)/pigment epithelium detachments were evaluated using the standardized procedures of the Vienna Reading Center. These morphologic characteristics were compared with functional variables [best‐corrected visual acuity (BCVA), contrast sensitivity (CS), retinal sensitivity/microperimetry, fixation stability], and patients’ subjective handicap from CSC using the ...

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    10. Case reports of coronary fibromuscular dysplasia and spontaneous coronary artery dissections

      Case reports of coronary fibromuscular dysplasia and spontaneous coronary artery dissections

      Spontaneous coronary artery dissection (SCAD) is an important cause of acute coronary syndrome especially in women. The most common underlying predisposing cause of SCAD is fibromuscular dysplasia (FMD), a non‐inflammatory arteriopathy that results in weakening of the affected arteries, and can cause dissection or aneurysm. Coronary FMD (CFMD) was described as rare, and was shown to cause SCAD in histopathological case reports. Unfortunately, CFMD is challenging to diagnose on coronary angiography, as the findings can be similar to other causes of coronary artery disease. Therefore, we illustrate two case examples of CFMD on coronary angiography, and highlight findings on ...

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    11. One‐to‐one registration of en‐face optical coherence tomography attenuation coefficients with histology of a prostatectomy specimen

      One‐to‐one registration of en‐face optical coherence tomography attenuation coefficients with histology of a prostatectomy specimen

      Optical coherence tomography (OCT), enables high‐resolution 3D imaging of the morphology of light scattering tissues. From the OCT signal, parameters can be extracted and related to tissue structures. One of the quantitative parameters is the attenuation coefficient; the rate at which the intensity of detected light decays in depth. To couple the quantitative parameters with the histology one‐to‐one registration is needed. The primary aim of this study is to validate a registration method of quantitative OCT parameters to histological tissue outcome through one‐to‐one registration of OCT with histology. We matched OCT images of unstained fixated ...

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    12. Ocular coherence tomography‐measured changes over time in anterior chamber angle and diurnal intraocular pressure after laser iridotomy: IMPACT study

      Ocular coherence tomography‐measured changes over time in anterior chamber angle and diurnal intraocular pressure after laser iridotomy: IMPACT study

      Importance The change in the anatomical dimensions over time and the effect on diurnal intraocular pressure (DIOP) following laser peripheral iridotomy is poorly understood. Background To evaluate change over time in anterior chamber angle anatomy following laser peripheral iridotomy (LPI) in patients with primary angle closure compared to control eyes. Additionally, the effect of LPI on DIOP fluctuation was investigated. Design Longitudinal, prospective, double‐randomized research study. Participants Adults with suspected angle closure or angle closure diagnosis referred to hospital services in the United Kingdom. Methods Thirty‐nine patients newly diagnosed with bilateral primary angle closure/suspects (PAC/PACS) received ...

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    13. Optical monitoring of adipose tissue destruction under encapsulated lipase action

      Optical monitoring of adipose tissue destruction under encapsulated lipase action

      Enzymatic destruction of adipose tissue has been achieved by encapsulation of lipase into the polymeric microcapsules. Adipose tissue destruction was delayed while lipase is encapsulated comparing with the direct lipase action as demonstrated by optical microscopy and optical coherence tomography in in vitro studies. Raman spectroscopy confirms that triglycerides in fat tissue were cleaved into free fatty acids, glycerol, and possible di‐ and monoglyceride residues. The results underpin the concept of local and controlled treatment of tissues via encapsulation. Effect of lipase encapsulation into the polymeric microcapsules on adipose tissue destruction compared to free lipase

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      Mentions: Valery V. Tuchin
    14. Histologic validation of ICDAS‐II and polarization sensitive optical coherence tomography to detect smooth surface early carious lesions

      Histologic validation of ICDAS‐II and polarization sensitive optical coherence tomography to detect smooth surface early carious lesions

      Aim This in vitro study aimed to histologically validate and compare the methods for detection of smooth surface early carious lesions (ECLs) that is , International caries detection and assessment system for the smooth surface (ICDAS‐II‐SSC), Polarization sensitive optical coherence tomography (PS‐OCT), and radiography. Methodology PS‐OCT images for scores 0‐3 of ICDAS‐II‐SSC were standardized according to ECLs’ depth. Preliminary PS‐OCT images for ICDAS‐II‐SSC score‐2 of pigmented ECLs showed reduced lesion depth and therefore were dichotomized into scores 2 and 2p for white and pigmented lesions (ICDAS‐II‐SSCm). ECLs on ...

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    15. Optical coherence tomography features in brothers with aspartylglucosaminuria

      Optical coherence tomography features in brothers with aspartylglucosaminuria

      Aspartylglucosaminuria is a lysosomal storage disorder enriched in Finland. We report on a pair of non‐Finnish siblings with aspartylglucosaminuria with autofluorescent inclusion bodies on optical coherence tomography, a finding not previously reported in this disorder. We performed a record review, neurological and neuropsychological evaluation, brain MRI, and optical coherence tomography for each patient. They are compound heterozygous for a 34‐kb deletion and a c.365C>A novel variant of the AGA gene. Autofluorescent inclusion bodies were found on optical coherence tomography in the older, more severely affected brother. We hypothesize the finding represents a noninvasive biomarker of disease ...

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    16. A review of non‐invasive imaging in extramammary Paget's disease

      A review of non‐invasive imaging in extramammary Paget's disease

      Extramammary Paget's Disease (EMPD) is a rare intraepithelial adenocarcinoma that classically manifests with pruritic, erythematous and scaling plaques. The clinical picture frequently mimics inflammatory or infectious conditions and is thus commonly misdiagnosed. The assessment of tumour margins is equally challenging as tumours have a propensity to spread beyond clinically visible boundaries. Appropriate non‐invasive diagnostic tools can assist in the early detection, diagnosis and management of EMPD. This paper will review the literature on non‐invasive imaging modalities used in EMPD. Articles from the PubMed database were selected based on relevance to the topic of this review. Articles that ...

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    17. Inherited epidermolysis bullosa: description of clinical and subclinical morphological features with optical coherence tomography

      Inherited epidermolysis bullosa: description of clinical and subclinical morphological features with optical coherence tomography

      Epidermolysis bullosa (EB) is an inherited skin disorder characterized by exacerbated skin and/or mucosal fragility and blister formation following minor mechanical trauma. Great scientific interest has recently been focused on gene therapies and transgenic epidermal grafting in EB patients. 1 Depending on the level of cleavage in the skin, EB is classified into 4 types: simplex (EBS), junctional (JEB), and dystrophic (DEB), and the extremely rare Kindler syndrome

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    18. Visualisation of the visual system

      Visualisation of the visual system

      In vivo imaging techniques have had a major impact on vision science research, not least because they provide access to the entire human visual pathway from the anterior eye to higher‐level processing areas within the brain. A special issue of Ophthalmic & Physiological Optics titled ‘Imaging the visual system: from the eye to the brain’ 1 highlighted the breadth of imaging‐related research in vision science by including papers that spanned ocular surface, 2 retinal 3 and brain 4 imaging. The special issue also emphasised fundamental research questions that can be addressed with imaging. These included diurnal changes in ocular ...

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    19. Assessment of macular ganglion cell complex using optical coherence tomography: impact of a paediatric reference database in clinical practice

      Assessment of macular ganglion cell complex using optical coherence tomography: impact of a paediatric reference database in clinical practice

      Importance Optical coherence tomography software classifies abnormality of macular ganglion cell‐inner plexiform layer thickness and macular retinal nerve fibre layer thickness based on adult series. Background We assessed the impact of using paediatric reference macular ganglion cell complex values instead of adult reference values. Design Cross‐sectional study. Primary and tertiary health‐care setting. Participants Out of 140 healthy participants aged 5 to 18 years, 90% were eligible. Methods Following a dilated eye examination and cycloplegic refraction, participants underwent optical coherence tomography ganglion cell scans (Topcon 3D OCT‐2000). Right eye measurements for superior, inferior, and total layer thickness ...

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    20. In vitro flow and optical coherence tomography comparison of two bailout techniques after failed provisional stenting for bifurcation percutaneous coronary interventions

      In vitro flow and optical coherence tomography comparison of two bailout techniques after failed provisional stenting for bifurcation percutaneous coronary interventions

      Objectives To evaluate, in vitro, SB stenting techniques after failed provisional stenting. We aimed to compare flows and stent strut apposition of T and protrusion (TAP) versus Reversed String (RS) techniques using a flow simulator, optical coherence tomography (OCT) using silicon bifurcation phantoms with different bifurcation angulations. Background While bifurcation coronary artery stenoses are preferably treated with provisional T‐stenting strategy, the preferred bailout two stents technique to treat the side branch remains unclear. Methods and results Eleven 30°‐angle and ten 60°‐angle bifurcation phantoms were used. After performing provisional stenting, TAP and RS techniques were compared in six ...

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    21. A prospective, single‐center, randomized study to assess whether automated coregistration of optical coherence tomography with angiography can reduce geographic miss

      A prospective, single‐center, randomized study to assess whether automated coregistration of optical coherence tomography with angiography can reduce geographic miss

      Objective We sought to evaluate whether automated coregistration of optical coherence tomography (OCT) with angiography reduces geographic miss (GM) during coronary stenting. Background Previous intravascular ultrasound or OCT studies have showed that residual disease at the stent edge or stent edge dissection was associated with stent thrombosis or edge restenosis. This has been termed GM. Methods Two hundred de novo coronary lesions were randomized in a 1:1 ratio to OCT‐guided percutaneous coronary intervention (PCI) with versus without automated coregistration of OCT with angiography. GM, the primary endpoint, was defined as angiographic ≥type B dissection or diameter stenosis >50 ...

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    22. Superparamagnetic graphene quantum dot as a dual‐modality contrast agent for confocal fluorescence microscopy and magnetomotive optical coherence tomography

      Superparamagnetic graphene quantum dot as a dual‐modality contrast agent for confocal fluorescence microscopy and magnetomotive optical coherence tomography

      A magnetic graphene quantum dot (MGQD) nanoparticle, synthesized by hydrothermally reducing and cutting graphene oxide‐iron oxide sheet, was demonstrated to possess the capabilities of simultaneous confocal fluorescence and magnetomotive optical coherence tomography (MMOCT) imaging. This MGQD shows low toxicity, significant tunable blue fluorescence and superparamagnetism, which can thus be used as a dual‐modality contrast agent for confocal fluorescence microscopy (CFM) and MMOCT. The feasibility of applying MGQD as a tracer of cells is shown by imaging and visualizing MGQD labeled cells using CFM and our in‐house MMOCT. Since MMOCT and CFM can offer anatomical structure and intracellular ...

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    1-24 of 915 1 2 3 4 ... 37 38 39 »
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