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    1. Retinal microvasculature impairments in patients with coronary artery disease: An optical coherence tomography angiography study

      Retinal microvasculature impairments in patients with coronary artery disease: An optical coherence tomography angiography study

      Purpose: To investigate the association between retinal microvasculature and the presence and severity of coronary artery disease (CAD) using optical coherence tomography angiography (OCTA). Methods: The cross-sectional study was conducted in Guangdong Provincial People's Hospital, China. Retinal microvasculature parameters were measured by OCTA of the optic disc, including the vessel density (VD) and retinal nerve fibre thickness of the radial peripapillary capillary. In terms of the entire macula, VD of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and foveal density (FD-300) were included. The Gensini score was used to evaluate the severity of coronary artery obstructive lesions ...

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    2. Changes in peripapillary and macular vascular density after laser selective trabeculoplasty: an optical coherence tomography angiography study

      Changes in peripapillary and macular vascular density after laser selective trabeculoplasty: an optical coherence tomography angiography study

      Objectives: To determine the effect of laser trabeculoplasty on peripapillary retinal nerve fibre layer thickness (RNFL), fovea avascular zone (FAZ), peripapillary and macular vessel density (VD) in glaucoma using with optical coherence tomography angiography (OCT-A). Methods: This was a prospective observational study performed at the Glaucoma Research Centre, Montchoisi Clinic, Lausanne, Switzerland. Thirty-seven eyes with primary open-angle glaucoma from 21 patients were included. Optical coherence tomography angiography (OCT-A) scans were performed before laser trabeculoplasty and at 2 and 6 months after the procedure. AngioVue AngioAnalytic (Optovue Inc, Fremont, CA, USA) software was used to analyse the RNFL, FAZ, peripapillary and ...

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    3. Noninvasive Evaluation of HepaRG Aggregates during Drug‐Induced Intrahepatic Cholestasis Using Optical Coherence Tomography

      Noninvasive Evaluation of HepaRG Aggregates during Drug‐Induced Intrahepatic Cholestasis Using Optical Coherence Tomography

      Intrahepatic cholestasis represents a typical manifestation of drug‐induced liver injury. Many researches have been made to understand the drug‐induced cholestasis using human cell based in vitro 3D model. Although noninvasive observation of 3D model will help unveil the hidden mechanism of this phenomenon, there have been few studies using the noninvasive methods. This study has attempted to evaluate the potential of noninvasive optical coherence tomography (OCT) combined with confocal laser scanning microscopy using the aggregates of a differentiated human hepatic cell line. From immunofluorescence staining images, the aggregates during drug‐induced cholestasis are divided into three groups: aggregates ...

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    4. Line-field confocal optical coherence tomography of benign dermal melanocytic proliferations: a case series

      Line-field confocal optical coherence tomography of benign dermal melanocytic proliferations: a case series

      Line‐field confocal optical coherence tomography (LC‐OCT) is a recently developed non‐invasive imaging technique able to combine the technical principles of conventional OCT (high in‐tissue penetration and visualization of the vertical plane) and reflectance confocal microscopy (high resolution). 1‐3 Indeed, LC‐OCT provides tridimensional images of the skin (vertical and horizontal planes) up to a 500‐µm depth and features excellent isotropic resolution (lateral: 1.3 µm; axial: 1.1 µm).

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    5. Line‐field confocal optical coherence tomography: a novel, non‐invasive imaging technique for a rapid, in‐vivo diagnosis of herpes infection of the skin

      Line‐field confocal optical coherence tomography: a novel, non‐invasive imaging technique for a rapid, in‐vivo diagnosis of herpes infection of the skin

      Line‐field confocal optical coherence tomography (LC‐OCT) is a new non‐invasive imaging technique for a real‐time, vertical and horizontal skin imaging with high resolution close to conventional histopathology (1‐2). As LC‐OCT has recently been marketed, few studies have been reported on its use in cutaneous disorders (2‐4), in some cases with an excellent correlation with conventional histopathology (3). The objective of the present study was to evaluate the LC‐OCT features in herpes infections (HSV/HVZ) of the skin.

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    6. Long‐term clinical, angiographic, and optical coherence tomography findings of Mg‐based bioresorbable scaffold in patients with acute coronary syndrome

      Long‐term clinical, angiographic, and optical coherence tomography findings of Mg‐based bioresorbable scaffold in patients with acute coronary syndrome

      Background This study sought to evaluate the clinical outcomes of patients treated with magnesium‐based bioresorbable scaffolds (MgBRS) in the context of acute coronary syndromes (ACS) at long‐term follow‐up (24 months). The study also aims to investigate the MgBRS performance by angiography and the healing and bioresorption pattern by optical coherence tomography (OCT) at 18 months. Methods Between December 2016 and December 2018, a total of 90 patients admitted for ACS and treated with MgBRS (Magmaris, Biotronik AG, Bülach, Switzerland) were enrolled in a multicenter prospective study. Clinical follow‐up was performed in all patients at 24 ...

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    7. The incidence, natural history, and predictive factors for tissue protrusion after drug‐eluting stent implantation

      The incidence, natural history, and predictive factors for tissue protrusion after drug‐eluting stent implantation

      Objectives and background Although tissue protrusion (TP) between the stent struts after stent implantation has been implicate as a potential factor of stent failure, the incidence, natural history, and predictive factor of TP after stent implantation remains unclear. This prospective study evaluated the fate of TP after drug‐eluting stent (DES) deployment using optical coherence tomography (OCT). Method and result This study analyzed TP for 42 lesions after DES in which three serial OCTs, including preprocedure, postprocedure, and 1‐month after the procedure were performed. TP was classified into the five groups: (a) persistent, (b) progressive, (c) healed, (d) regressive ...

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      Mentions: Kenichi Fujii
    8. Back-calculation of keratometer index based on OCT data and raytracing - a Monte Carlo simulation

      Back-calculation of keratometer index based on OCT data and raytracing - a Monte Carlo simulation

      Purpose: This study aims to develop a raytracing-based strategy for calculating corneal power from anterior segment optical coherence tomography data and extracting the individual keratometer index, which converts the corneal front surface radius to corneal power. Methods: A large OCT dataset (10,218 eyes of 8,430 patients) from the Casia 2 (Tomey, Japan) was post-processed in MATLAB (MathWorks, USA). Radius of curvature, asphericity of the corneal front and back surface, central corneal thickness and pupil size (aperture) were used to trace a bundle of rays through the cornea and derive the best focus plane. Corneal power was calculated with ...

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    9. Retinal cross‐section motion correction in three‐dimensional retinal optical coherence tomography

      Retinal cross‐section motion correction in three‐dimensional retinal optical coherence tomography

      Motion correction is an important issue in ophthalmic optical coherence tomography (OCT), and can improve the ability of datasets to reflect the physiological structures of tissues and make visualization and subsequent analysis easier. In this study, we present a novel method to correct the cross-sectional motion artifacts in retinal OCT volumes. Motion along the x-direction (fast-scan direction) is corrected through the normalized cross-correlation algorithm, while axial motion compensation is performed using the polynomial fitting method on the inner segment/outer segment (IS/OS) layer segmented by the shortest path faster algorithm (SPFA). The results of volunteers with central serous chorioretinopathy ...

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    10. Optical coherence tomography-based non-invasive evaluation of premalignant lesions in SKH-1 mice

      Optical coherence tomography-based non-invasive evaluation of premalignant lesions in SKH-1 mice

      Non-invasively diagnosis of actinic keratoses (AK) is important for preventing cutaneous squamous cell carcinoma (cSCC). Optical coherence tomography (OCT) can be used to detect the cross-sectional skin micromorphology with sufficient resolution and imaging depth. It has the capability to reveal the changes in skin microstructure during the development of AK. Therefore, OCT can serve as a tool for diagnosing AK. This study explores the feasibility of OCT in evaluating the structural changes in mouse skin at the different stages following exposure to ultraviolet radiation. The performance of OCT is compared with histology, the gold standard in this context. The imaging ...

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    11. Interactive effect of photoperiod and temperature on the induction and termination of embryonic diapause in the migratory locust

      Interactive effect of photoperiod and temperature on the induction and termination of embryonic diapause in the migratory locust

      Background Diapause plays a vital role in the survival and population reproduction of the migratory locust in temperate regions. Although some studies have suggested that photoperiod and temperature are two important environmental factors involved in the induction and termination of embryonic diapause in locusts, the independent or synergetic roles of these two factors are still unclear. Results We designed crossover experiments to investigate the effects of photoperiod, temperature and treatment time on the induction and termination of embryonic diapause in locusts by optical coherence tomography (OCT), which can track the entire embryonic developmental process via noninvasive 3D real‐time imaging ...

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    12. Reflectance Confocal Microscopy, Optical Coherence Tomography, and Multiphoton Microscopy in Inflammatory Skin Disease Diagnosis

      Reflectance Confocal Microscopy, Optical Coherence Tomography, and Multiphoton Microscopy in Inflammatory Skin Disease Diagnosis

      Background and objectives: Technological advances in medicine have brought about many novel skin imaging devices. This review aims to evaluate the scientific evidence supporting the use of noninvasive optical imaging techniques to aid in the diagnosis and prognosis of inflammatory skin diseases. Study design/materials and methods: PubMed and Scopus were searched in September 2020 according to PRISMA guidelines for articles using reflectance confocal microscopy (RCM), optical coherence tomography (OCT), and multiphoton microscopy (MPM) in inflammatory skin diseases, excluding studies monitoring treatment efficacy. Results: At the time of the study, there were 66 articles that addressed the utilization of noninvasive ...

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      Mentions: UC Irvine
    13. Indocyanine green-enhanced multimodal photoacoustic microscopy and optical coherence tomography molecular imaging of choroidal neovascularization

      Indocyanine green-enhanced multimodal photoacoustic microscopy and optical coherence tomography molecular imaging of choroidal neovascularization

      Photoacoustic microscopy (PAM) has great potential for visualization of the microvasculature with high spatial resolution and contrast. Early detection and differentiation of newly developed blood vessels named choroidal neovascularization (CNV) from normal vasculature remains a challenge in ophthalmology. Exogenous contrast agents can assist with improving PAM sensitivity, leading to differentiation of CNV. Here, an FDA-approved indocyanine green (ICG) was utilized as a PAM contrast agent. ICG was conjugated with RGD peptides, allowing the ICG to bind to the integrin expressed in CNV. Molecular PAM imaging showed that ICG-RGD can target CNV for up to 5 days post intravenous administration in ...

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    14. Functional characteristics of glaucoma related arcuate defects seen on OCT en face visualisation of the retinal nerve fibre layer

      Functional characteristics of glaucoma related arcuate defects seen on OCT en face visualisation of the retinal nerve fibre layer

      Purpose To assess continuity of perimetric defects corresponding to arcuate defects seen on optical coherence tomography (OCT) en face reflectance images of the retinal nerve fibre layer (RNFL) in patients with glaucoma. Methods Seven patients with glaucoma who had arcuate structural defects on OCT RNFL en face images were recruited. Static suprathreshold stimuli were presented along different meridians to localise perimetric defects in the corresponding hemifield. Then two contrasts, one 6 dB greater than the other, were used with kinetic perimetry to assess the slope of the defect. Findings with kinetic and 24‐2 perimetry were compared. Results Static perimetry ...

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    15. Swept‐source optical coherence tomography angiography findings in hypertensive chorioretinopathy

      Swept‐source optical coherence tomography angiography findings in hypertensive chorioretinopathy

      Purpose To study malignant hypertension ocular findings with swept source optical coherence tomography (SS‐OCT) and optical coherence tomography angiography (OCT‐A). Methods In this retrospective study, we included patients with malignant hypertension associated to hypertensive chorioretinopathy. Clinical characteristics with multimodal imaging including SS‐OCT and OCT‐A were evaluated at baseline and during follow‐up. Results Seventeen eyes of nine patients were included. Fundus examination revealed signs of hypertensive chorioretinopathy in all cases. At baseline, SS‐OCT showed serous retinal detachment in 7 eyes, macular edema in 15 eyes and hard exudates in 13 eyes. Central macular thickness was ...

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    16. Effect of axial length on peripapillary microvasculature: an optical coherence tomography angiography study

      Effect of axial length on peripapillary microvasculature: an optical coherence tomography angiography study

      Purpose To investigate the effects of axial length (AL) on the peripapillary microvascular density acquired from optical coherence tomography angiography (OCTA). Methods A total of 111 eyes from 111 normal healthy subjects were examined. The subjects were divided into three groups according to the AL: Group 1 (AL: <24.0 mm; 35 eyes), Group 2 (AL: 24.0–25.99 mm; 37 eyes), and Group 3 (AL: ≥26 mm; 39 eyes). Peripapillary OCTA images were acquired using 6 × 6 mm angiography scans, and vessel density (VD) and perfusion density (PD) of the superficial capillary plexus were calculated automatically. Vessel density ...

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    17. Initial Study for the Determination of the Sequence of Intersecting Lines between Gel Pens and Seals by Optical Coherence Tomography

      Initial Study for the Determination of the Sequence of Intersecting Lines between Gel Pens and Seals by Optical Coherence Tomography

      Determining the sequence of intersecting lines is a significant issue in the forensic document examination that can reveal the fraud or distinguish between different allegations. Optical coherence tomography (OCT) is a high-resolution cross-sectional imaging technique that has been introduced into forensic science field recently. The potential of OCT as a novel method to determine the sequence of intersecting lines was examined for the first time. In this study, a spectral-domain OCT system with a center wavelength of 900 nm was employed to perform nondestructive examination on determining the sequence of 18 heterogeneous intersecting line samples produced using three types of ...

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    18. Assessing the Outcomes of Focused Heating of the Skin by a Long-Pulsed 1064 nm Laser with an Integrated Scanner, Infrared Thermal Guidance, and Optical Coherence Tomography

      Assessing the Outcomes of Focused Heating of the Skin by a Long-Pulsed 1064 nm Laser with an Integrated Scanner, Infrared Thermal Guidance, and Optical Coherence Tomography

      Background and Objective Long‐term benefits can be predicted by the incorporation of more intelligent systems in lasers and other devices. Such systems can produce more reliable zones of thermal injury when used in association with non‐invasive monitoring and precise laser energy delivery. The more classical endpoint of tumor destruction with radiofrequency or long‐pulsed (LP) 1064 nm laser is the non‐specific appearance of tissue graying and tissue contraction. Herein we discuss combining non‐invasive LP 1064 nm Nd:YAG treatment with the assistance of optical coherence tomography (OCT) and the forward‐looking infrared (FLIR) thermal camera while ...

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    19. Albumin‐PEG‐Based Biomaterial for Laser‐Tissue Soldering and Its Real‐Time Monitoring With Swept‐Source Optical Coherence Tomography

      Albumin‐PEG‐Based Biomaterial for Laser‐Tissue Soldering and Its Real‐Time Monitoring With Swept‐Source Optical Coherence Tomography

      Background and Objectives The study presents a noninvasive, real‐time monitoring technique for the cross‐sectional imaging of the laser‐tissue soldering process with a swept‐source optical coherence tomography (SSOCT) system. The study also aims at performing a comparative study of the laser‐tissue soldering (LTS) process using optimized compositions of albumin as solder biomaterials. Study Design/Materials and Methods The experimental study was conducted both ex vivo and in vivo to assess the superiority of the LTS process over conventional methods using a noninvasive imaging tool. In our attempt to combine the two techniques into one diagnostic tool ...

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    20. Classification of Salivary Gland Tumors Based on Quantitative Optical Coherence Tomography

      Classification of Salivary Gland Tumors Based on Quantitative Optical Coherence Tomography

      Background and Objectives Visual inspection is the primary diagnostic method for oral diseases, and its accuracy of diagnosis mainly depends on surgeons’ experience. Histological examination is still the golden standard, but it is invasive and time‐consuming. In order to address these issues, as a noninvasive imaging technique, optical coherence tomography (OCT) can differentiate oral tissue with advantages of real‐time, in situ , and high resolution. The aim of this study is to explore optimal quantitative parameters in OCT images to distinguish different salivary gland tumors. Study Design/Materials and Methods OCT images of four salivary gland tumors were obtained ...

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    21. In vivo dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography

      In vivo dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography

      Decreased mobility of the human eardrum, the tympanic membrane (TM), is an essential indicator of a prevalent middle ear infection. The current diagnostic method to assess TM mobility is via pneumatic otoscopy, which provides subjective and qualitative information of subtle motion. In this study, a handheld spectral-domain pneumatic optical coherence tomography system was developed to simultaneously measure the displacement of the TM, air pressure inputs applied to a sealed ear canal, and to perform digital pneumatic otoscopy. A novel approach based on quantitative parameters is presented to characterize spatial and temporal variations of the dynamic TM motion. Furthermore, the TM ...

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    22. Swept‐source optical coherence tomography objective composite activity score for uveitis

      Swept‐source optical coherence tomography objective composite activity score for uveitis

      Purpose To develop an objective intraocular inflammation composite score. Methods Cross‐sectional study. Non‐invasive image acquisition and processing were conducted from April 2017 to April 2019. Inflammation‐grade stratified eyes from patients with active, inactive uveitis and healthy controls were recruited. After clinical assessment, four anterior and posterior segment image acquisition protocols per eye, using swept‐source optical coherence tomography (SS‐OCT), were performed at inclusion. Eight imaging biomarkers in three domains: anterior, intermediate and posterior were studied. They were ranked and selected by discriminatory power and correlation with clinical scores. A final SS‐OCT‐derived composite uveitis activity ...

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