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    1. Melanoma Blood Vessel Changes Detected with OCT Imaging

      Melanoma Blood Vessel Changes Detected with OCT Imaging

      An international team of researchers has proven that dynamic optical coherence tomography (D-OCT) imaging of melanoma reveals changes to the blood vessels that correlate with the depth of its invasion, which could lead to a faster method of rapidly assessing the severity of a melanoma. Nathalie de Carvalho, of the University of Modena and Reggio Emilia, explained that cancers grow their own blood vessel network to supply oxygen and nutrients. “We analyzed the shapes of the vessels in the OCT images of melanomas and correlated the frequency of different shapes with the Breslow depths [the thickness of the tumors, measured ...

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    2. AO-OCT Comes into Focus

      AO-OCT Comes into Focus

      Adaptive optics (AO) technology is often used to correct for wavefront distortions imparted when light travels through complex optical systems, enhancing image resolution and facilitating diffraction-limited optics. It has played a particularly prominent role in ophthalmic imaging, where retinal tissue imaging is limited by inherent aberrations in the eye. Given the widespread adoption of OCT in clinical diagnostics over the last 20 years, these two techniques should be natural partners. But because of technological limitations on both sides, practical applications of AO-OCT have been difficult to implement. Improved imaging AO refers to a family of techniques used for correcting distortions ...

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    3. Advances in Optical Coherence Tomography

      Advances in Optical Coherence Tomography

      Optical coherence tomography (OCT) is a high-resolution, three-dimensional, noninvasive imaging technique. It is often called an optical ultrasound because it relies on time-of-flight information, similar to ultrasound imaging, to obtain subsurface information. The success of this technique has been fueled by a unique combination of technical and commercial factors, which include major investment in lasers, optical fibers, and sensors for telecommunications. That OCT is benefitting from these advances is proven in its applications across the health care industry. With close to a billion-dollar market size, OCT is seeing increased acceptance in areas such as interventional cardiology, dermatology, and ophthalmology, and ...

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    4. OCT Promising as Clear Point-of-Care Solution

      OCT Promising as Clear Point-of-Care Solution

      Medical devices at the point of care allow clinicians to do what they do best: determine a patient’s exact condition and a course of treatment. These technologies work best when they fit seamlessly into the provider-patient workflow without a steep learning curve or worry about the underlying scientific principles, and without the high cost seen for so many medical technologies. Optical coherence tomography (OCT) is an imaging technology that has become well-known in recent years for its proven diagnostic ability, particularly in the eye care realm. This technology is now the gold standard for diagnosing eye diseases such as ...

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    5. Vying for Dominance: Swept-Source vs. Spectral-Domain OCT

      Vying for Dominance: Swept-Source vs. Spectral-Domain OCT

      Optical coherence tomography (OCT) is among the most widely used in vivo optical diagnostic techniques. This high-resolution 3D imaging modality, with market size approaching $1 billion, has established itself as an indispensable tool for ophthalmology and is seeing growing acceptance in interventional cardiology, dermatology and nondestructive testing. OCT combines micron-level resolution with high speed and penetration up to 2 to 3 mm in the scattering tissue. In addition, instrumentation is relatively inexpensive and portable when compared to other 3D medical imaging modalities, such as MRI and CT. Figure 1. An example of using SS-OCT for studying therapeutic potential of allogeneic ...

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    6. Evolution of the Supercontinuum Light Source

      Evolution of the Supercontinuum Light Source

      For many applications, coherent light at a single frequency is more than adequate. But having a light source that combines the properties of a laser with the broad bandwidth of an incandescent bulb and a short pulse duration opens up a new realm of possibilities in medical imaging, communications, displays and materials studies. One of most extraordinary discoveries of optical effects came in 1970 from Robert Alfano and Stanley Shapiro 1 . The duo demonstrated the conversion of a narrow band color — for example, green light of short duration — to white color and beyond. This was accomplished by nonlinear effect, and ...

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    7. Blackbird, TU Munich, Collaborate for OCT in Auto Manufacturing

      Blackbird, TU Munich, Collaborate for OCT in Auto Manufacturing

      Remote laser welding system manufacturer Blackbird Robotersysteme GmbH is participating in a research project with the Technical University of Munich’s Institute for Machine Tools and Industrial Management and multiple industrial partners to explore optical coherence tomography's potential for remote laser welding in auto manufacturing. The project will investigate innovative technology for more flexibility in body construction, particularly electro mobility. Germany's Federal Ministry of Education and Research is sponsoring the project under the Photonics Research Germany research incentive program. The German government's goal is to advance electromobility. Disappointed electric vehicle sales point to inflexible production structures which ...

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    8. Adoption Depends on Meeting Clinical Needs

      Adoption Depends on Meeting Clinical Needs

      Every year, I am amazed and impressed by the number and variety of presentations at conferences in the field of biophotonics . We are blessed by the seemingly endless ways to manipulate and measure light, relatively inexpensively, in our pursuit of powerful new ways to understand, diagnose and treat disease. Much human ingenuity has been applied to overcoming difficult technical problems and pushing back the bounds of our knowledge. But then I usually pause for reflection: How much of this advanced technology and research ends up in practical, routine use by clinicians caring for their patients? Of course, there are some ...

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    9. Superluminescent LEDs Bridge the Gap

      Superluminescent LEDs Bridge the Gap

      Optical coherence tomography (OCT) is perhaps the most widely known application for SLED sources. This noninvasive imaging technique produces real-time, cross-sectional images with a resolution of a few microns. In just 20 years, it has become a well-established medical procedure in the fields of ophthalmology, cardiology, gastroenterology and dermatology, with a market size approaching $1 billion for system sales. While swept source lasers have received much attention with the switch to higher resolution spectral domain (SD)-OCT about a decade ago, SLEDs still remain the preferred light source for most OEM applications because of their simplicity, compactness and cost. OCT ...

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    10. Added Intelligence Transforms Medical Sensors Into Diagnostic Devices

      Added Intelligence Transforms Medical Sensors Into Diagnostic Devices

      According to a 2017 market report 1 by market research and strategic consulting company Yole Développement of Lyon, France, the medical industry has a growing interest in solid-state technologies in order to answer the challenges of miniaturization, patient safety, early diagnostics, low power consumption and cost-savings. “Three hundred fifty million dollars of solid-state optical sensor devices for medical imaging applications has been sold in 2016,” said Benjamin Roussel, business unit manager of Yole’s MedTech activity. Yole expects a growth of 8.3 percent in the next five years, he said. Today’s optical sensors measure a variety of ...

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    11. Advances in Surgical Microscopes Pave the Way to Improved Outcomes

      Advances in Surgical Microscopes Pave the Way to Improved Outcomes

      The new generation of devices can heighten resolution, integrate patient data with intraoperative images and allow for more exact localization of surgical targets. By integrating intelligence, video, intraoperative-imaging and navigation technologies, today’s surgical microscopes provide surgeons with insights to improve their decision-making at the point of care and provide patients with the best possible outcomes. Surgical microscopes enable physicians to perform delicate surgery through tiny incisions. With a microscope, a surgeon can visualize anatomy within small cavities not perceptible by the human eye alone. They have long been used for ophthalmology.

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    12. OCT Angiography Opens Eyes

      OCT Angiography Opens Eyes

      Dr. Daniela Ferrara, an assistant professor of ophthalmology at Tufts University School of Medicine in Boston, began researching retinal diseases in 1998. Age-related macular degeneration (AMD), a leading cause of blindness in elderly individuals of European descent, has been a recurring topic in her research. However, it was not until about two years ago — when Ferrara started testing prototype optical coherence tomography angiography (OCT-A) devices — that she saw just how much at the back of her patients’ eyes had been escaping her own eyes. For example, Ferrara identified choroidal neovascularization (CNV) in the OCT-A scan of an elderly patient long ...

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    13. Where Does OCT Go From Here?

      Where Does OCT Go From Here?

      OCT-A — optical coherence tomography angioplasty — which allows imaging without dye, is a promising breakthrough in the detection of early-stage glaucoma. And swept-source OCT has opened new possibilities for diagnosing diabetic retinopathy and early macular degeneration. Although ophthalmology continues to dominate the OCT landscape, this imaging technology also has seen new adaptations outside that field. In dermatology, it is used for the diagnosis and treatment of

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    14. St. Jude Medical Reaches Primary Endpoint for OCT Trial

      St. Jude Medical Reaches Primary Endpoint for OCT Trial

      A trial undertaken by medical device company St. Jude Medical Inc. has met its primary endpoint as the first multicenter, prospective, randomized, controlled study comparing optical coherence tomography- (OCT), intravascular ultrasound- (IVUS) and angiography-guided outcomes for percutaneous coronary intervention (PCI). The ILUMIEN III study demonstrated PCI guided by OCT to be superior to angiography in stent expansion and procedural success and non-inferior to IVUS-guided PCI in post-procedure minimal stent area (MSA). Physicians employed the St. Jude Medical OPTIS Integrated and ILUMIEN OPTIS PCI optimization systems, along with the Dragonfly imaging catheters designed for high-resolution imaging, to assess vessel and lesion ...

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      Mentions: St. Jude Medical
    15. OCT-A Detects Early Stage Glaucoma

      OCT-A Detects Early Stage Glaucoma

      Optical coherence tomography angiography (OCT-A) was used at the earliest stages of glaucoma to identify the characteristic patterns of different forms of the disease. OCT-A, a noninvasive technique that employs en face reconstruction of OCT combined with motion contrast processing to reveal perfused retinal vasculature, could enable doctors to diagnose glaucoma cases earlier than ever before and potentially slow down the progression of the disease.

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      Mentions: Richard B. Rosen
    16. OCT Angiography Opens Eyes

      OCT Angiography Opens Eyes

      Dr. Daniela Ferrara, an assistant professor of ophthalmology at Tufts University School of Medicine in Boston, began researching retinal diseases in 1998. Age-related macular degeneration (AMD), a leading cause of blindness in elderly individuals of European descent, has been a recurring topic in her research. However, it was not until about two years ago — when Ferrara started testing prototype optical coherence tomography angiography (OCT-A) devices — that she saw just how much at the back of her patients’ eyes had been escaping her own eyes. For example, Ferrara identified choroidal neovascularization (CNV) in the OCT-A scan of an elderly patient long ...

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    17. SS-OCT PCIe Card from Keysight Technologies

      SS-OCT PCIe Card from Keysight Technologies

      Keysight Technologies Inc. offers swept source optical coherence tomography (SS-OCT) application options for the U5303A compact, dual-channel ADC card, delivering high dynamic range and a high effective number of bits for enhanced image quality. The new options support up to 1 GS/s on the 12-bit, high-speed data acquisition peripheral component interconnect express (PCIe) card. Image acquisition is featured at a rate of 200 kHz, continuously. The real-time processing solution allows OEMs to develop SS-OCT engines using the development environment provided, which includes a graphical user interface and C++ programming language. The new options also ensure improved spurious-free dynamic range ...

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    18. Clinicians Demand More From Optical Devices

      Clinicians Demand More From Optical Devices

      From the ubiquity of smartphones to an aging population, the modern world offers the optical sector a wealth of opportunities to innovate for the health care sector. Optical technologies have a long history of providing a rapid and noninvasive way of diagnosing, imaging and operating that other methods simply cannot match. It’s little wonder then that the health care sector continues to call for fresh ideas from the optics industry. From novel therapies to adding new functionality to existing devices, in addition to exploiting the huge growth of products in the consumer market, the opportunities for innovation are extensive ...

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    19. Photonics Media Seeks Presenters for Biophotonic Imaging Digital Conference

      Photonics Media Seeks Presenters for Biophotonic Imaging Digital Conference

      Researchers in the field of bioimaging around the world are invited to give presentations at a digital conference to be hosted by Photonics Media this summer. “Biophotonic Imaging for Medicine” will focus on a range of light-based imaging and microscopy techniques for diagnosing and assessing illness, or studying other attributes and functions of biological tissue in a biomedical context. It will take place from 1 to 5 p.m. EST on Thursday, June 11. Click here to submit an abstract. Like Photonics Media’s popular series of webinars, the conference will be presented free via the Web to a knowledgeable ...

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    20. UV-VIS Spectroscopy in the Clinic – What’s Stopping It?

      UV-VIS Spectroscopy in the Clinic – What’s Stopping It?

      Bigio’s team isn’t the only one to encounter this difficulty in attracting funding. Dr. Adam Wax’s group at Duke University has been developing a technique – angle-resolved low-coherence interferometry, or a/LCI – enabling early detection of cancer and other biomedical applications by measuring the average size of cell nuclei using scattered light. The focus of the a/LCI instrument has been Barrett’s esophagus, a precursor to esophageal cancer. But Wax is also looking beyond the upper GI tract. In his research lab at Duke, he and colleagues have been working to develop the technology further, to bring ...

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    21. Seeing the Light: How Photonics Continues to Improve Eyesight

      Seeing the Light: How Photonics Continues to Improve Eyesight

      In 1981, Rangaswamy “Sri” Srinivasan, a researcher at IBM’s Thomas J. Watson Research Center, experimented with a pulsed argon fluoride (ArF) excimer laser on turkey leftovers, and lasers have had an ever-growing role in ophthalmology ever since. That landmark resulted in the first laser-based vision-correction techniques, including laser-assisted in situ keratomileusis (lasik) and photorefractive keratectomy (PRK) techniques. Ophthalmology uses numerous photonic technologies – Nd:YAG and femtosecond excimer lasers, 3-D imaging techniques and OCT (optical coherence tomography) – to diagnose and treat eye diseases and vision problems. Today, these techniques are being combined into systems that are revolutionizing the eye surgeon ...

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    22. Ultrafast Laser Systems Are Stepping Up to Meet Industry Needs

      Ultrafast Laser Systems Are Stepping Up to Meet Industry Needs

      The wide spectral bandwidth of ultrafast lasers also is useful in optical coherence tomography, widely used to provide 3-D images of tissue. Here, the very broad spectral output of supercontinuum lasers allows for very high axial resolution imaging in multiple user-defined wavelength bands optimized for the tissue being imaged. “The high power and spectral brightness of supercontinuum lasers also allows for deep-tissue imaging, such as in highly scattering media, or in vivo imaging, where signal levels can be very low,” Seaton said.

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      Mentions: Fianium
    23. OCT Technologies, Applications Showing Great Promise

      OCT Technologies, Applications Showing Great Promise

      OCT is growing. As we reported in the July issue, the optical imaging market is set to reach $1.9 billion by the end of 2018 – a compound annual growth rate of 11.37 percent – and OCT makes up 70 percent or more of that market, according to a study by Research and Markets. But if you only go by the numbers, you don’t get the whole story. Sure, 70 percent is great for OCT, but where is it really going? To get a more in-depth perspective, BioPhotonics interviewed representatives from companies that are big players in the OCT ...

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    24. Imaging Tech Could Lower Heart Disease Deaths

      Imaging Tech Could Lower Heart Disease Deaths

       Under a two-year, $498,325 Small Business Innovation Research (SBIR) Phase II National Science Foundation grant, Wasatch Photonics Inc. will continue the development of its intravascular optical coherence tomography technique, which shows where lesions and plaques have formed. Physicians can use these images to determine the best course of action, and to resolve issues such as stent placement. The technology will provide a new tool to identify and treat coronary artery disease, which “affects an estimated 16 million Americans and is a primary cause of heart attacks and strokes,” said William J. Brown, vice president of business development. “Identifying and ...

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