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    1. OCT Branches Out

      OCT Branches Out

      Anyone who has recently had an eye examination may have been ushered into a room that contained an optical coherence tomography (OCT) scanner. This technology uses backscattered light to construct cross-section images of the retina, similar to the way sound waves are used to construct an ultrasound image, except at a much higher resolution. Imaging the thickness of the retina can help to reveal various diseases and conditions. Most people who dutifully put their head on the chin rest of the OCT scanner and stare at the red light are unaware of how the technology works. They also may not ...

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    2. VIS-OCT needs stable, versatile light sources

      VIS-OCT needs stable, versatile light sources

      Optical coherence tomography (OCT) is the gold standard for noninvasive retinal imaging, enabling ophthalmologists to diagnose and treat multiple ocular diseases. Compared to traditional OCT, which uses near-infrared (NIR) wavelengths of light, visible-light OCT (VIS-OCT) offers superior spatial resolution and novel functional imaging capabilities. VIS-OCT provides the most accurate means for measuring retinal oxygen saturation, a key biomarker for understanding changes in tissue metabolism associated with the pathology of various retinal diseases. Traditional OCT has dominated ophthalmic diagnostics for the past 30 years. Thanks to investment in and development of key OCT components, there is an opportunity to accelerate adoption ...

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    3. OCT Technique Offers High Speed, High Resolution

      OCT Technique Offers High Speed, High Resolution

      Researchers at the University of Washington have modified the standard process of OCT (optical coherence tomography) to detect minute changes in response to light in individual photoreceptors in the living eye . The technique has potential in the testing of therapies such as stem cells or gene therapy to treat retinal disease. “Typically, retinal OCT systems are implemented by raster scanning a point of light across the retina. This provides excellent contrast, but at the cost of speed due to dual-axis scanning,” corresponding author Ramkumar Sabesan, assistant research professor of ophthalmology, told Photonics Media. “On the other end, full-field OCT systems ...

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    4. OCT Reveals Biomechanics of a Developing Mouse Heart, Live in 4D

      OCT Reveals Biomechanics of a Developing Mouse Heart, Live in 4D

      Scientists from Stevens Institute of Technology and Baylor College of Medicine used 4D optical coherence tomography (OCT) to study the pumping mechanism underlying the developing mammalian heart. 4D OCT allowed them to investigate the functional relation between blood flow and heart wall dynamics within different regions of the embryonic heart at a level of detail not currently accessible by other methods. 4D OCT could potentially enable scientists to assess cardiac pumping over embryonic development as the heart tube remodels, which could reveal functional changes during early cardiogenesis that lead to congenital heart defects. The researchers used 4D OCT to obtain ...

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    5. Single-Photon Technology Could Allow High-Sensitivity, Low-Power OCT

      Single-Photon Technology Could Allow High-Sensitivity, Low-Power OCT

      A detection technology used in quantum optics also could be used to perform OCT (optical coherence tomography) with lower light power than previously possible, potentially improving the imaging quality available from OCT. “For clinical applications, being able to perform OCT with low light power is crucial because safety standards limit the light intensity levels that can be used,” research team leader Sylwia Kolenderska, from the University of Auckland, said. “In some cases, these power levels are not high enough to achieve good image quality.” While developing an OCT method based on quantum light, researchers at the University of Auckland discovered ...

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    6. The Eyes Behind Surgical Robots

      The Eyes Behind Surgical Robots

      By the turn of the century, Intuitive Surgical Inc.’s da Vinci surgical system, which was approved by the FDA in 2000, was used for general laparoscopic surgical procedures and even cardiovascular surgeries — a high watermark in the early years. The system is still in wide use today. Intuitive Surgical Inc.’s da Vinci is among the most well-known surgical robotic systems. Courtesy of Intuitive Surgical Inc. Fast forward two decades, and today’s surgical robots are more precise and user-friendly, and capable of highly delicate microsurgeries, thanks to advancements in optical technology that have allowed for safe and effective ...

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      Mentions: FDA
    7. VIS-OCT Opens Eyes to New Approaches

      VIS-OCT Opens Eyes to New Approaches

      First reported in 1991 by Huang and colleagues 1 , OCT has become an important imaging tool for ophthalmology following innovations over the past three decades. OCT noninvasively provides 3D in vivo optical biopsy with microscopic resolution in the eye at a depth range up to the choroid 2 . Besides 3D anatomical imaging, OCT can also provide functional information. The most notable functional extension is OCT angiography (OCTA), which can map the microvasculature in the eye without contrast agent and is being investigated in clinical ophthalmology.

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    8. VIS-OCT offers sight line

      VIS-OCT offers sight line

      The benefits of optical coherence tomography (OCT) have long been known as an imaging tool in ophthalmology, enabling the examination of the eye at microscopic resolution. But what may not be widely appreciated is that the use of visible light sources can improve upon the results of this well-developed technique in the detection and understanding of various eye-related diseases such as macular degeneration and glaucoma. While most commercial OCT and OCTA (angiography) systems use NIR light for economic and technical reasons, broadband visible light sources have expanded from 400 to 2000 nm or more. This has enabled the imaging of ...

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    9. OCT and Ophthalmology in the Age of Artificial Intelligence, Tuesday Oct 8, 2019 1:00P EDT

      OCT and Ophthalmology in the Age of Artificial Intelligence, Tuesday Oct 8, 2019 1:00P EDT

      This webinar will provide an executive overview for leaders in imaging and ophthalmology on how artificial intelligence (AI) is transforming the field of medical imaging. Presenter Nishant Mohan will provide a hands-on demonstration of how to develop a deep-learning AI system from scratch, giving attendees critical insight into how to use this powerful tool. Separating the hype from reality, Mohan will discuss essential concepts behind the revolutionizing power of AI. In addition, he will present critical factors in the ecosystem that is driving AI technology and major AI platforms. He will provide specific examples of the application of AI in ...

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    10. Melanoma Blood Vessel Changes Detected with OCT Imaging

      Melanoma Blood Vessel Changes Detected with OCT Imaging

      An international team of researchers has proven that dynamic optical coherence tomography (D-OCT) imaging of melanoma reveals changes to the blood vessels that correlate with the depth of its invasion, which could lead to a faster method of rapidly assessing the severity of a melanoma. Nathalie de Carvalho, of the University of Modena and Reggio Emilia, explained that cancers grow their own blood vessel network to supply oxygen and nutrients. “We analyzed the shapes of the vessels in the OCT images of melanomas and correlated the frequency of different shapes with the Breslow depths [the thickness of the tumors, measured ...

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    11. AO-OCT Comes into Focus

      AO-OCT Comes into Focus

      Adaptive optics (AO) technology is often used to correct for wavefront distortions imparted when light travels through complex optical systems, enhancing image resolution and facilitating diffraction-limited optics. It has played a particularly prominent role in ophthalmic imaging, where retinal tissue imaging is limited by inherent aberrations in the eye. Given the widespread adoption of OCT in clinical diagnostics over the last 20 years, these two techniques should be natural partners. But because of technological limitations on both sides, practical applications of AO-OCT have been difficult to implement. Improved imaging AO refers to a family of techniques used for correcting distortions ...

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    12. Advances in Optical Coherence Tomography

      Advances in Optical Coherence Tomography

      Optical coherence tomography (OCT) is a high-resolution, three-dimensional, noninvasive imaging technique. It is often called an optical ultrasound because it relies on time-of-flight information, similar to ultrasound imaging, to obtain subsurface information. The success of this technique has been fueled by a unique combination of technical and commercial factors, which include major investment in lasers, optical fibers, and sensors for telecommunications. That OCT is benefitting from these advances is proven in its applications across the health care industry. With close to a billion-dollar market size, OCT is seeing increased acceptance in areas such as interventional cardiology, dermatology, and ophthalmology, and ...

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    13. OCT Promising as Clear Point-of-Care Solution

      OCT Promising as Clear Point-of-Care Solution

      Medical devices at the point of care allow clinicians to do what they do best: determine a patient’s exact condition and a course of treatment. These technologies work best when they fit seamlessly into the provider-patient workflow without a steep learning curve or worry about the underlying scientific principles, and without the high cost seen for so many medical technologies. Optical coherence tomography (OCT) is an imaging technology that has become well-known in recent years for its proven diagnostic ability, particularly in the eye care realm. This technology is now the gold standard for diagnosing eye diseases such as ...

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    14. Vying for Dominance: Swept-Source vs. Spectral-Domain OCT

      Vying for Dominance: Swept-Source vs. Spectral-Domain OCT

      Optical coherence tomography (OCT) is among the most widely used in vivo optical diagnostic techniques. This high-resolution 3D imaging modality, with market size approaching $1 billion, has established itself as an indispensable tool for ophthalmology and is seeing growing acceptance in interventional cardiology, dermatology and nondestructive testing. OCT combines micron-level resolution with high speed and penetration up to 2 to 3 mm in the scattering tissue. In addition, instrumentation is relatively inexpensive and portable when compared to other 3D medical imaging modalities, such as MRI and CT. Figure 1. An example of using SS-OCT for studying therapeutic potential of allogeneic ...

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    15. Evolution of the Supercontinuum Light Source

      Evolution of the Supercontinuum Light Source

      For many applications, coherent light at a single frequency is more than adequate. But having a light source that combines the properties of a laser with the broad bandwidth of an incandescent bulb and a short pulse duration opens up a new realm of possibilities in medical imaging, communications, displays and materials studies. One of most extraordinary discoveries of optical effects came in 1970 from Robert Alfano and Stanley Shapiro 1 . The duo demonstrated the conversion of a narrow band color — for example, green light of short duration — to white color and beyond. This was accomplished by nonlinear effect, and ...

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    16. Blackbird, TU Munich, Collaborate for OCT in Auto Manufacturing

      Blackbird, TU Munich, Collaborate for OCT in Auto Manufacturing

      Remote laser welding system manufacturer Blackbird Robotersysteme GmbH is participating in a research project with the Technical University of Munich’s Institute for Machine Tools and Industrial Management and multiple industrial partners to explore optical coherence tomography's potential for remote laser welding in auto manufacturing. The project will investigate innovative technology for more flexibility in body construction, particularly electro mobility. Germany's Federal Ministry of Education and Research is sponsoring the project under the Photonics Research Germany research incentive program. The German government's goal is to advance electromobility. Disappointed electric vehicle sales point to inflexible production structures which ...

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    17. Adoption Depends on Meeting Clinical Needs

      Adoption Depends on Meeting Clinical Needs

      Every year, I am amazed and impressed by the number and variety of presentations at conferences in the field of biophotonics . We are blessed by the seemingly endless ways to manipulate and measure light, relatively inexpensively, in our pursuit of powerful new ways to understand, diagnose and treat disease. Much human ingenuity has been applied to overcoming difficult technical problems and pushing back the bounds of our knowledge. But then I usually pause for reflection: How much of this advanced technology and research ends up in practical, routine use by clinicians caring for their patients? Of course, there are some ...

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    18. Superluminescent LEDs Bridge the Gap

      Superluminescent LEDs Bridge the Gap

      Optical coherence tomography (OCT) is perhaps the most widely known application for SLED sources. This noninvasive imaging technique produces real-time, cross-sectional images with a resolution of a few microns. In just 20 years, it has become a well-established medical procedure in the fields of ophthalmology, cardiology, gastroenterology and dermatology, with a market size approaching $1 billion for system sales. While swept source lasers have received much attention with the switch to higher resolution spectral domain (SD)-OCT about a decade ago, SLEDs still remain the preferred light source for most OEM applications because of their simplicity, compactness and cost. OCT ...

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    19. Added Intelligence Transforms Medical Sensors Into Diagnostic Devices

      Added Intelligence Transforms Medical Sensors Into Diagnostic Devices

      According to a 2017 market report 1 by market research and strategic consulting company Yole Développement of Lyon, France, the medical industry has a growing interest in solid-state technologies in order to answer the challenges of miniaturization, patient safety, early diagnostics, low power consumption and cost-savings. “Three hundred fifty million dollars of solid-state optical sensor devices for medical imaging applications has been sold in 2016,” said Benjamin Roussel, business unit manager of Yole’s MedTech activity. Yole expects a growth of 8.3 percent in the next five years, he said. Today’s optical sensors measure a variety of ...

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    20. Advances in Surgical Microscopes Pave the Way to Improved Outcomes

      Advances in Surgical Microscopes Pave the Way to Improved Outcomes

      The new generation of devices can heighten resolution, integrate patient data with intraoperative images and allow for more exact localization of surgical targets. By integrating intelligence, video, intraoperative-imaging and navigation technologies, today’s surgical microscopes provide surgeons with insights to improve their decision-making at the point of care and provide patients with the best possible outcomes. Surgical microscopes enable physicians to perform delicate surgery through tiny incisions. With a microscope, a surgeon can visualize anatomy within small cavities not perceptible by the human eye alone. They have long been used for ophthalmology.

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    21. OCT Angiography Opens Eyes

      OCT Angiography Opens Eyes

      Dr. Daniela Ferrara, an assistant professor of ophthalmology at Tufts University School of Medicine in Boston, began researching retinal diseases in 1998. Age-related macular degeneration (AMD), a leading cause of blindness in elderly individuals of European descent, has been a recurring topic in her research. However, it was not until about two years ago — when Ferrara started testing prototype optical coherence tomography angiography (OCT-A) devices — that she saw just how much at the back of her patients’ eyes had been escaping her own eyes. For example, Ferrara identified choroidal neovascularization (CNV) in the OCT-A scan of an elderly patient long ...

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    22. Where Does OCT Go From Here?

      Where Does OCT Go From Here?

      OCT-A — optical coherence tomography angioplasty — which allows imaging without dye, is a promising breakthrough in the detection of early-stage glaucoma. And swept-source OCT has opened new possibilities for diagnosing diabetic retinopathy and early macular degeneration. Although ophthalmology continues to dominate the OCT landscape, this imaging technology also has seen new adaptations outside that field. In dermatology, it is used for the diagnosis and treatment of

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    23. St. Jude Medical Reaches Primary Endpoint for OCT Trial

      St. Jude Medical Reaches Primary Endpoint for OCT Trial

      A trial undertaken by medical device company St. Jude Medical Inc. has met its primary endpoint as the first multicenter, prospective, randomized, controlled study comparing optical coherence tomography- (OCT), intravascular ultrasound- (IVUS) and angiography-guided outcomes for percutaneous coronary intervention (PCI). The ILUMIEN III study demonstrated PCI guided by OCT to be superior to angiography in stent expansion and procedural success and non-inferior to IVUS-guided PCI in post-procedure minimal stent area (MSA). Physicians employed the St. Jude Medical OPTIS Integrated and ILUMIEN OPTIS PCI optimization systems, along with the Dragonfly imaging catheters designed for high-resolution imaging, to assess vessel and lesion ...

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      Mentions: Abbot
    24. OCT-A Detects Early Stage Glaucoma

      OCT-A Detects Early Stage Glaucoma

      Optical coherence tomography angiography (OCT-A) was used at the earliest stages of glaucoma to identify the characteristic patterns of different forms of the disease. OCT-A, a noninvasive technique that employs en face reconstruction of OCT combined with motion contrast processing to reveal perfused retinal vasculature, could enable doctors to diagnose glaucoma cases earlier than ever before and potentially slow down the progression of the disease.

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      Mentions: Richard B. Rosen
    1-24 of 69 1 2 3 »
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