Articles from Home: SPIE.org

1. Lihong Wang and Hsin-I Wu receive Goodman Book Writing Award from SPIE and OSA

   Explore Article Home: SPIE.org (Mar 11 2010)

   BELLINGHAM, Washington, and WASHINGTON, D.C., USA -- Lihong V. Wang and Hsin-I Wu are recipients of the 2010 Joseph W. Goodman Book Writing Award for their book Biomedical Optics: Principles and Imaging, the Optical Society (OSA) and SPIE have announced. The Goodman Award, a biennial award funded by a personal gift from Joseph W. and Hon Mai Goodman, recognizes a recent and outstanding book in the field of optics and photonics that has contributed significantly to research, teaching, or the optics and photonics industry. This year, the Goodman Book Writing Award will be bestowed upon Wang and Wu at the ... (Read Full Article)
   

   Comment on Article Mentions:   Lihong V. Wang   Texas A&M University   Hsin-i Wu

2. Visualizing ocular perfusion with optical microangiography

   Explore Article Home: SPIE.org (Mar 3 2010) Ophthalmology

   Better assessment of ocular blood circulation may provide important diagnostic and treatment information for eye pathologies such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Currently, the preferred methods to visualize ocular blood perfusion in the clinic are fluorescein angiography (FA) and indocyanine green angiography (ICGA). Both provide detailed maps of the retina and choroid that are useful in decision making. However, injecting dyes with possible side effects is undesirable. Moreover, those methods cannot provide depth-resolved visualization of vasculatures. Therefore, a noninvasive technique that can show retinal and choroidal blood perfusion in depth would be a significant advance. We have ... (Read Full Article)
   

   Comment on Article Mentions:   Ruikang K. Wang   Lin An   Oregon Health & Science University

3. Optical micro-endoscopes for 3D in-vivo imaging

   Explore Article Home: SPIE.org (Feb 22 2010) Endoscopy , Probes

   Electrothermal micromirrors and a flexible printed circuit board permit fast, small optical coherence tomography of internal organs. Optical coherence tomography (OCT) is a medical optical imaging technique that can achieve high-resolution 3D images (1-15μm)1 by detecting infrared light scattered by body tissue. It has an imaging depth range of about 3mm in highly-scattered tissue and has already been widely used for external imaging, e.g., for eye diseases and skin cancer diagnosis. It would be useful to apply OCT to internal imaging, since about 85% of all cancers originate from the surface layers of internal organs. As these layers are within ... (Read Full Article)
   

   Comment on Article Mentions:   Lei Wu   Huikai Xie   University of Florida

4. BaySpec OCT spectral engine at Photonics West

   Explore Article Home: SPIE.org (Jan 22 2010) Other Business News

   BaySpec, Inc., a world leader in advanced spectroscopy solutions, is pleased to announce the successful outcome of a collaboration on a new OCT spectral engine that allows up to three times greater collection efficiency than standard Czerny-Turner spectrographs, while offering 10x the signal/noise ratio improvement in detector sensitivity. BaySpec will be exhibiting at SPIE Photonics. BaySpec's DeepView Spectrograph, designed for the expanding spectral domain-optical coherence tomography (SD-OCT) market, provides high throughput spectral measurements in an ultra compact package and factory calibrated for long-life and low-cost of ownership. (Read Full Article)
   

   Comment on Article Mentions:   e2v   BaySpec Inc.   Eric Bergles

5. Jim Fujimoto video: Biophotonics and optical coherence tomography

   Explore Article Home: SPIE.org (Jan 21 2010)

   Comment "Great video Jim!" - Eric Swanson

   James. G. Fujimoto is a principal investigator in the Research Laboratory of Electronics (RLE) at the Massachusetts Institute of Technology (MIT). The RLE Laser Medicine and Medical Imaging Group and its close collaborators were the originators of optical coherence tomography (OCT). The group currently works to further understand and exploit the capabilities of OCT technology, with ongoing investigations in topics related to optical coherence microscopy development and optical biopsy using OCT. Fujimoto's area of research involves the development and application of femtosecond laser technology, studies of ultrafast phenomena, and laser medicine and surgery. He is chair of the annual Biomedical ... (Read Full Article)
   

   1 Comment Mentions:   Massachusetts Institute of Technology   James G. Fujimoto

6. Imaging algorithm visualizes early heart abnormalities

   Explore Article Home: SPIE.org (Nov 17 2009) Cardiology

   Combining a post-acquisition rearrangement procedure with optical coherence tomography can provide high temporal resolution for capturing subtle dynamics in the early avian embryonic heart. ying abnormalities that occur during early cardiac development is very important for understanding congenital heart defects. Optical coherence tomography (OCT) is a noninvasive imaging modality based on low-coherence interferometry that is capable of micrometer-scale resolution and 1–2mm of depth penetration in embryonic tissue. OCT can visualize and quantify real-time heart dynamics in 3D, making it a useful tool for assessing cardiac development. Real-time volume imaging performed with current systems, however, does not provide the necessary temporal ... (Read Full Article)
   

   Comment on Article Mentions:   Madhusudhana Gargesha   Michael W. Jenkins   Andrew M. Rollins

7. Improved contrast in clinical imaging

   Explore Article Home: SPIE.org (Nov 9 2009) Dermatology , Oncology

   Spectral-domain optical coherence tomography performed simultaneously in two distinct wavelength bands permits better diagnosis of tumors. Optical coherence tomography (OCT) is a standard tool for detailed two- and three-dimensional noninvasive analysis of retinal diseases in ophthalmology. It is also a promising research instrument, permitting early tumor diagnosis in skin and bladder tissue. OCT provides high-resolution images of biological tissue using the interference between incident and returning (reflected or backscattered) light1 to obtain structural information that can be used to distinguish between a skin tumor and healthy skin. A particularly important use is to distinguish benign and malignant tumors by means ... (Read Full Article)
   

   Comment on Article

8. High-speed, full-range optical coherence tomography

   Explore Article Home: SPIE.org (Oct 13 2009) Ophthalmology

   A new technique to remove complex-conjugate artifacts inherent to conventional Fourier-domain interferometry can double accessible imaging depth. In the past decade, optical coherence tomography (OCT)1 has emerged as an important, noninvasive tool for depth-resolved imaging of biological structures. Current developments are shifting its focus toward spectral-domain and swept-source techniques, since these frequency-domain OCT (FDOCT) versions have better acquisition speed and sensitivity than time-domain imaging.2 However, a major drawback limiting FDOCT's practical application is the complex-conjugate ambiguity. The detected, real-valued spectral interferogram is Fourier transformed to localize the scatter in the sample. The Fourier transform of a real-valued function is Hermitian ... (Read Full Article)
   

   Comment on Article Mentions:   Ruikang K. Wang   Oregon Health & Science University

9. New biophotonics techniques hold promise but need translation, say researchers at NIH-SPIE 'Bench to Bedside' workshop

   Explore Article Home: SPIE.org (Oct 7 2009)

   BETHESDA, Maryland, USA, and BELLINGHAM, Washington, USA -- Leading-edge advances such as a revolutionary cardiology treatment and noninvasive optical techniques for studying the brain combined with pragmatic discussions on research focus and funding highlighted a two-day inter-institute workshop last week at the National Institutes of Health (NIH) in Bethesda, Maryland. Approximately 350 preeminent researchers in biophotonics attended the workshop, titled "Optical Diagnostics and Biophotonic Methods from Bench to Bedside." Amir Gandjbakhche, NIH, and Bruce Tromberg, Beckman Laser Institute and Univ. of California, Irvine, chaired the meeting, held 1-2 October. SPIE provided logistical support for the event. Attendees including Christopher Contag, ... (Read Full Article)
   

   Comment on Article Mentions:   LightLab Imaging   UC Irvine   Anita Mahadevan-Jansen

10. Detecting action-potential-correlated scattering changes in single neurons

    Explore Article Home: SPIE.org (Sep 16 2009) Microscopy

    Optical coherence microscopy has potential as a tool for noninvasively measuring electrical activity in single neurons based on changes in their intrinsic optical properties. A central goal of neuroscience is to understand how groups of neurons interact to give rise to the myriad functions of the nervous system. This task is extremely difficult in part because of the technical challenge of recording the electrical activity of many neurons simultaneously without disturbing their environment. Although several methods exist, new techniques are in strong demand. One promising approach is based on noninvasively detecting changes in the optical properties of neural tissue that ... (Read Full Article)
    

    Comment on Article Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign

11. A laryngoscope for office-based imaging of human vocal folds using OCT

    Explore Article Home: SPIE.org (Sep 7 2009) Otolaryngology

    We developed a laryngoscope with an integrated OCT beam path for office-based non-contact imaging of human vocal folds. In combination with conventional videolaryngoscopy superficial and subsurface lesions can be detected. For error-free interpretation of OCT images obtained in office-based examination motion artifacts have to be considered. To demonstrate the implications on OCT images we simulated probe and patient movements for different commercial systems representing the three OCT modalities and analyzed the OCT data. Our results show that time domain and fourier domain OCT with a swept light source are probably better suited for noncontact imaging of awake patients than the ... (Read Full Article)
    

    Comment on Article Mentions:   Henning Wisweh   Laser Zentrum Hannover   Holger Lubatschowski

12. Enhancing tissue-contrast imaging of the anterior eye

    Explore Article Home: SPIE.org (Jul 9 2009) Ophthalmology

    Polarization-sensitive optical coherence tomography enables tissue-sensitive visualization of the front of the eye. Optical coherence tomography (OCT) has become one of the most important diagnostic tools in ophthalmology. Originally used to examine the posterior eye, which includes the retina and optic nerve, it now is being applied to the anterior eye, which includes the cornea and iris.1,2 The back of the eye has several tissue layers, each with different light-scattering properties. OCT uses these differences for image contrast that clearly distinguishes the posterior tissues. However, the scattering properties of anterior eye tissue layers are similar, so it is difficult to ... (Read Full Article)
    

    Comment on Article Mentions:   Yoshiaki Yasuno   Masahiro Yamanari   University of Tsukuba

13. Four-dimensional visualization with optical coherence tomography

    Explore Article Home: SPIE.org (Jul 6 2009) Ophthalmology

    A new system for ultrahigh-speed imaging of the anterior segment of the eye retains micrometer resolution. The widespread development of improved imaging modalities dedicated to visualizing the anterior segment of the eye has regenerated interest in ophthalmic studies.1–3 Among methods such as slit-scanning topography, Scheimpflug imaging, and high-frequency ultrasonography, optical coherence tomography (OCT) has generated particular attention. OCT emerged from investigations into low-coherence interferometry and optical reflectometry.4 As an echo technique, it can be thought of as similar to ultrasound. However, as OCT is based on light, it can deliver much higher resolution, similar to low-power microscopy. As an interferometric ... (Read Full Article)
    

    Comment on Article Mentions:   Maciej Wojtkowski   Optopol Technology   Optopol SOCT Copernicus

14. Towards freehand image acquisition in optical coherence tomography

    Explore Article Home: SPIE.org (Jun 30 2009) Probes

    A new data-capture method could provide increased flexibility for clinical imaging applications. Optical coherence tomography (OCT), a biomedical diagnostic-imaging technique, is currently transitioning from the research laboratory into clinical practice.1 Providing micrometer-scale resolution over millimeter-scale fields of view, OCT is the optical analog of ultrasound. It uses low-coherence interferometry to perform optical ranging in biological tissue. Clinical applications under investigation include optical biopsy2 and detection of tumor margins during image-guided surgery.3 The clinical applications of OCT benefit from its real-time imaging capability and diverse sample-arm designs, including hand-held probes, rotating fiber-optic catheters, and miniature needles. The real-time diagnostic capability has ... (Read Full Article)
    

    Comment on Article Mentions:   Stephen A. Boppart   Steven G. Adie   University of Illinois at Urbana-Champaign

15. Monitoring oncological surgery using optical coherence tomography

    Explore Article Home: SPIE.org (Jun 19 2009) Oncology

    Detailed, real-time imaging allows for adjustment of surgical margins, thus sparing healthy tissue and increasing the likelihood of complete tumor removal. Development of local recurrence is one of the main causes of unsatisfactory long-term recovery prospects following cancer surgery. Determining the adequate balance between radical tumor removal and maximum preservation of the surrounding tissue is therefore very important for cancer management and, subsequently, the patient's quality of life. Rates of recurrence following surgical resection are appreciably high for a number of cancers. Following transurethral resection of bladder tumors (TURBT), they are reported to be as high as 40–80%, with a ... (Read Full Article)
    

    Comment on Article Mentions:   Elena V. Zagaynova   Vladimir Zagaynov   Natalia D. Gladkova

16. Optical coherence angiography for the eye

    Explore Article Home: SPIE.org (Jun 10 2009) Ophthalmology

    A new technique for monitoring blood flow will help investigate eye functions and retinal disease. Poor blood supply is one of the main causes of several retinal diseases. Vascular disorders and impaired circulation are observed in major eye diseases that cause blindness, including age-related macular degeneration (AMD)1 and glaucoma.2 A noninvasive, 3D imaging tool for major vascular systems of the eye might be helpful for understanding and diagnosing eye diseases. Circulation abnormalities are typically diagnosed using fluorescence angiography, in which injected fluorescent dye is detected. However, this technique is invasive, may have side effects, and cannot be used for patients ... (Read Full Article)
    

    Comment on Article Mentions:   Shuichi Makita   Yoshiaki Yasuno   University of Tsukuba

17. Where is retinal optical coherence tomography heading?

    Explore Article Home: SPIE.org (May 3 2009) Ophthalmology

    Recent advances in imaging technology facilitate cellular-resolution retinal imaging and wide-field 3D visualization, enabling enhanced penetration below the retina for routine diagnosis. Optical coherence tomography (OCT) is a rapidly emerging, noninvasive, optical diagnostic-imaging technique that enables in-vivo cross-sectional visualization of internal microstructure in biological systems at a resolution of a few micrometers.1 Novel high-speed detection techniques and the recent development of tunable light sources with ultrabroad bandwidth have revolutionized imaging performance and the clinical feasibility of OCT. As a consequence, it has become an optical analog to computed tomography and magnetic-resonance imaging. Although OCT does not enable full-body imaging, it ... (Read Full Article)
    

    Comment on Article Mentions:   Wolfgang Drexler   Cardiff University

18. Multifunctional optical imaging reveals tissue properties of the anterior eye

    Explore Article Home: SPIE.org (Apr 24 2009) Ophthalmology , Doppler

    A combination of polarization and Doppler-flow imaging for optical coherence tomography enhances image contrast without sacrificing acquisition speeds. Corneal and anterior-segment optical coherence tomography (CAS-OCT) is an imaging mode used to obtain cross-sectional images of the anterior eye segment in a noncontact and noninvasive manner.1 CAS-OCT has been used in clinics for diagnosis and basic research of ocular diseases such as glaucoma. Although conventional OCT helps to visualize the distribution of backscattering intensities from tissues, unlike histological techniques it does not guarantee clear differentiation of individual tissues. To enhance the contrast of OCT images, the birefringence and Doppler flow of ... (Read Full Article)
    

    Comment on Article Mentions:   Shuichi Makita   Yoshiaki Yasuno   Masahiro Yamanari

19. Optical coherence tomography holds promise for conserving art

    Explore Article Home: SPIE.org (Apr 21 2009) Art

    OCT has migrated successfully from medical imaging to materials science, where it is used online to monitor varnish removal from paintings. Noninvasive examinations of human patients and art objects share more than the important modus operandi of ‘do no harm.’ Soon after medical x-rays were discovered, they were applied to inspect the underlying layers of paintings. More recently, that extended to the newer modality of x-ray tomography. Now, optical coherence tomography (OCT), which acquires and processes optical signals to produce high-quality 3D images, has entered the picture. Medical OCT was first described in 1991,1 and reports of its use to ... (Read Full Article)
    

    Comment on Article Mentions:   Dalsa   Piotr Targowski   Michalina Góra

20. Imaging the Eye: A video interview with Robert Zawadzki

    Explore Article Home: SPIE.org (Apr 9 2009) Ophthalmology

    Robert J. Zawadzki's research interests focus on the aging human eye. He is working on development of new instrumentation for high-resolution in vivo retina imaging, which allows for visualization of individual cellular structures. This includes optical coherence tomography (OCT) and adaptive optics (AO), scanning laser opthalmoscopy (SLO), and combinations of all three. Adaptive optics can be used to compensate for issues that come up when working with imperfections of the human eye, while OCT (Read Full Article)
    

    Comment on Article Mentions:   UC Davis   Robert J. Zawadzki

21. Cellular imaging of the living human retina

    Explore Article Home: SPIE.org (Apr 6 2009) Ophthalmology

    A device combining optical coherence tomography and adaptive optics can capture micron-scale 3D pictures of the retina. Viewing the retina through the eye's cornea and crystalline lens dates back to the time of Helmholtz, inventor of the ophthalmoscope. Ophthalmoscopes have advanced substantially since then and are now an indispensable non-invasive tool for diagnosis and treatment monitoring. While there are three principal types—conventional ophthalmoscopes, confocal scanning laser ophthalmoscopes (cSLOs), and optical coherence tomography (OCT)).123 The latter has changed the diagnosis and monitoring of retinal and optic nerve disease most. (Read Full Article)
    

    Comment on Article Mentions:   John S. Werner   UC Davis   Robert J. Zawadzki

22. High-speed visualization of tissue-perfusion dynamics

    Explore Article Home: SPIE.org (Mar 29 2009) Doppler

    Optical coherence tomography enhances clinical diagnosis and could increase our understanding of major disease progression. Quantitative knowledge about blood flow in tissues is crucial for evaluating health, and different methods have been applied to assess blood-tissue perfusion, such as Doppler ultrasound and laser-Doppler imaging. Doppler optical coherence tomography (DOCT), a sophisticated non-invasive technique based on optical interferometry which can capture detailed images of biological tissues, provides the best available spatial and temporal resolution to localize and quantify blood flow.1 The first DOCT systems date back to the late 1990s, but the method has yet to find its way into clinical ... (Read Full Article)
    

    Comment on Article Mentions:   Rainer A. Leitgeb   Medical University of Vienna

23. Optical coherence tomography captures embryonic heart dynamics

    Explore Article Home: SPIE.org (Feb 24 2009) Cardiology , Developmental Biology

    An advanced imaging technique has both the spatial and temporal resolution to investigate the developing heart in important animal models such as chicks and mice. In studying the mechanisms that drive early heart formation, researchers rely primarily on static methods such as histology and immunohistochemistry. During cardiac looping, the minuscule heart transforms from a tubular form to a four-chambered heart, a complex process which relies upon mechanical stresses from the functioning heart for feedback. Optical coherence tomography (OCT) imaging emdash a sophisticated, noninvasive technique that can capture detailed images of biological tissue by measuring optical scattering emdash offers the ability ... (Read Full Article)
    

    Comment on Article Mentions:   Michael W. Jenkins   Andrew M. Rollins   Case Western Reserve University

24. Fourier domain mode locking: new lasers for optical coherence tomography

    Explore Article Home: SPIE.org (Feb 3 2009) Tunable Sources

    A new operating regime for rapidly wavelength swept, narrowband light sources has enabled high-performance biomedical imaging. Optical coherence tomography (OCT) generates micron-scale resolution, cross-sectional images of tissue by measuring the echo time delay of backscattered light (see Figure 1).1 Recent work showed that rapidly wavelength-swept narrowband laser sources can be used for this technique.2 This approach, called swept source OCT (ss-OCT), is similar to the frequency modulated radar used in police speed guns, but uses light instead of radio waves. In the technique, one depth scan is generated for each sweep of the laser. The system performance depends on the ... (Read Full Article)
    

    Comment on Article Mentions:   Massachusetts Institute of Technology   James G. Fujimoto   Robert A. Huber

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