1. 1-6 of 6
    1. Quantitative Measurement of Tear Film Dynamics with Optical Coherence Tomography and Statistical Decision Theory

      Quantitative Measurement of Tear Film Dynamics with Optical Coherence Tomography and Statistical Decision Theory

      Currently, there are about 40 to 60 million Americans suffering from Dry Eye Syndrome (DES); this serious public health problem will worsen with the explosive aging population created by baby boomers, where DES has a high incidence. However, the therapeutics for DES are elusive because our understanding of DES is so elementary, especially the correlation between symptoms and the diagnosis. Unfortunately, a quantitative diagnosis, which is the prerequisite to advance the management of DES, is yet to be realized. We are seeking the next breakthrough in DES management by providing a quantitative diagnosis, with the combination of optical coherence tomography ...

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    2. Photoreceptor and Choroid Development Assessed with Handheld SD-OCT

      Photoreceptor and Choroid Development Assessed with Handheld SD-OCT

      Objective: Optical coherence tomography (OCT) allows examination of the human retina. While conventional OCT devices are limited mainly to adults, the availability of a handheld system has expanded the use of this technique to pediatric populations, with the primary clinical applications being shaken baby syndrome and retinopathy of prematurity. We sought to apply OCT imaging to neonatal population to assess retinal development. Methods: Subjects imaged at the Duke Neonatal Intensive Care Unit (NICU) and Duke Birthing Center. Subjects were imaged with a Bioptigen Hand Held Probe SD-OCT (HHP-SDOCT) (Bioptigen, Research Triangle Park, NC, USA). For this study, only "normal" subjects ...

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    3. Adaptive optics for studying visual function: A comprehensive review

      Adaptive optics for studying visual function: A comprehensive review
      ompared to most ophthalmic technologies, adaptive optics, or AO, is relatively young. The first working systems were presented in 1997 and, owing in part to its complexity, the development of AO systems has been relatively slow. Nevertheless, AO for vision science is coming of age and the scope of applications continues to increase. Applications of AO can be broadly split along two lines; for retinal imaging and for testing visual function. This review will focus on the applications of adaptive optics for testing visual function. Since this represents only a subset of the field of AO for ophthalmoscopy, it is ...
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    4. A novel scanning system for imaging the entire anterior segment of the eye using an anterior segment OCT

      A novel scanning system for imaging the entire anterior segment of the eye using an anterior segment OCT
      The ability to image the entire anterior segment from anterior surface of the cornea to the posterior surface of the lens is crucial for understanding accommodation and the efficacy of accommodative intraocular lenses. A novel scanning system for an anterior segment optical coherence tomography (AS-OCT) system was designed to achieve this goal. In contrast to the traditional telecentric scanning method, this system shines OCT beams close to normal incidence on the ocular surfaces to increase the amount of light scattered back from those surfaces to the system. To achieve normal incidence on all the surfaces using one focusing system, one ...
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    5. Research-grade OCT: what new can it reveal about photoreceptors?

      Research-grade OCT: what new can it reveal about photoreceptors?
      Abstract The recent commercialization of spectral-domain optical coherence tomography (SD-OCT) has provided the vision research community with unprecedented imaging capabilities in turn-key form. These commercial systems are being applied to a plethora of ocular applications and have become highly popular. The shear success of the commercial form raises obvious questions about the virtue of research-grade OCT systems in conducting vision research. Here I will present several examples in which research-grade systems, developed in our Indiana laboratory, have provided fundamental information about the photoreceptor layer not attainable with current commercial systems. These examples required extending the performance capabilities of SD-OCT in ...
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    6. Monitoring mouse retinal degeneration with high-resolution spectral-domain optical coherence tomography

      Progression of retinal degeneration in a mouse model was studied in vivo with high-resolution spectral-domain optical coherence tomography (SD-OCT). Imaging in 3D with high depth resolution (<3 μm), SD-OCT resolved all the major layers of the retina of control C57BL/6J mice. Images of transgenic mice having a null mutation of the rhodopsin gene revealed the anatomical consequences of retinal degeneration: thinning of the outer retina, including the outer plexiform layer (OPL), outer nuclear layer (ONL), and inner and outer segments (IS/OS). We monitored the progression of retinal degeneration in rd1 mice (C3H/HeJ) by periodically imaging the same ...
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    1-6 of 6
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