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    1. Optical Coherence Tomography: Advances in functional OCT

      Optical Coherence Tomography: Advances in functional OCT

      A range of extensions enable optical coherence tomography (OCT) to achieve functional imaging, providing useful information about tissue dynamics and expanding OCT's clinical relevance. Optical coherence tomography (OCT) is used mainly to depict structural characteristics. But this versatile imaging technique is also able to provide functional imaging of live, intact tissue, and in recent years, researchers have increasingly pursued extensions to realize this potential. These extensions expand OCT's relevance for clinical work by providing richer information about such dynamics as blood flow, collagen organization, and oxygenation. This article, a summary of an extensive and fully referenced review, 1 ...

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      Mentions: Duke University
    2. Telecom tech continues to advance OCT

      Telecom tech continues to advance OCT

      Keep your ear to the ground for an increase in the repurposing for bio applications of technologies designed for non-bio applications, including telecom and automotive. Telecom we've already seen—and are continuing to see. Optical coherence tomography ( OCT ) is a good example: This technique, which has substantially impacted ophthalmology and is emerging for many other applications, was enabled by technology developed decades ago for telecommunications. OCT generates volume images at high speed, traditionally at millimeter-to-centimeter depths with micron-scale resolution. But now, in the MIT lab of OCT pioneer Jim Fujimoto, researchers have achieved high-speed 3D OCT imaging at cubic-meter ...

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    3. Optical Coherence Tomography: Bio and beyond - OCT advance breaks barriers in imaging scale, cost

      Optical Coherence Tomography: Bio and beyond - OCT advance breaks barriers in imaging scale, cost

      A research team representing commerce and academia has made a welcome breakthrough in optical coherence tomography (OCT): meter-scale OCT. 1 (For more on OCT, see "Advances in functional OCT," page 66.) Not only does the achievement provide dramatically greater capability than before, it also portends high-performance, low-cost systems, with wide-ranging impact for industrial applications as well as biomedical. It's no surprise that OCT has achieved its greatest success in ophthalmology , and shown the most promise for other uses (such as gastroenterology, cardiology, and dermatology) that benefit from endoscopy-enabled or superficial imaging, as it produces volume images with micron-scale resolution ...

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    4. Diagnostics/Optical Coherence Tomography: Light source calibration for accurate depth readings from FD-OCT

      Diagnostics/Optical Coherence Tomography: Light source calibration for accurate depth readings from FD-OCT

      Producing accurate depth information with Fourier-domain optical coherence tomography (FD-OCT) depends on proper light source calibration; there are different considerations for nonlinear sampling in the two primary FD-OCT implementations: spectral-domain (SD-OCT) and swept-source (SS-OCT). Fourier-domain optical coherence tomography (FD-OCT) is a coherence gating technique. It acquires, as a function of optical wavenumber, the interferometric signal generated by mixing backscattered light from the sample with reference light at a fixed group delay. Back-reflection or backscattered light from samples at different delays generates oscillations or fringes in the interference spectrum. Increased delay produces higher oscillation frequency in the interference spectrum. It is ...

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      Mentions: Exalos
    5. Beyond Better Clinical Care: Optical Coherence Tomography's Economic Impact

      Beyond Better Clinical Care: Optical Coherence Tomography's Economic Impact

      The optical coherence tomography (OCT) industry has grown dramatically in its first 25 years, and while the positive effects on patient clinical care are the most important measure of OCT's success, its contributions to the economy in jobs, tax receipts, and healthcare savings are also noteworthy. The field of optical coherence tomography (OCT) has grown dramatically since its discovery in the early 1990s. The commercialization and growth of OCT, which has occurred over the past 25 years, has been highly impactful scientifically, clinically, and economically. Many factors have helped drive this success, starting with the clinical need for new ...

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    6. Intraoperative OCT improves ophthalmic surgery

      Intraoperative OCT improves ophthalmic surgery

      The most popular examination method in ophthalmology today is optical coherence tomography (OCT ). Traditionally, OCT examinations have been performed pre- and post-operatively in vitreo-retinal surgery. While this application of the technology has enabled outcomes to be measured and results to be documented, surgeons have not had the ability to incorporate the results to improve surgical treatments. But with considerable advances to OCT—including high-definition OCT (HD OCT), 3D visualization , and adaptive optics —the integration of these methods into the surgical microscope is logical. The technology is now helping ophthalmologists carry out delicate eye surgeries. In today's integrated microscopy systems ...

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    7. OCT Developments Address Skin

      OCT Developments Address Skin

      Recent developments in optical coherence tomography (OCT) address skin cancer diagnosis. MedLumics (Madrid, Spain) has launched a three-year initiative to translate research into new clinical applications—with help from $4.9 million (€3.6 million) in Series A funding from EU joint investors. Called the BiopsyPen Project, the initiative is led by MedLumics and the Medical University of Vienna (Austria), along with European members including VTT Finland (Espoo, Finland), Delft University of Technology in The Netherlands, Exalos (Schlieren, Switzerland), the Polytechnic University of Madrid, and Optocap (Livingston, Scotland). The organizations are working to develop a handheld system for point-of-care diagnosis ...

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    8. Life sciences seen as key at SPIE Photonics West '14

      Life sciences seen as key at SPIE Photonics West '14

      Again and again at SPIE Photonics West 2014 (February 1–6), I found evidence of the importance of life sciences applications among optics and photonics suppliers and systems developers. Despite setbacks imposed by the U.S. government's "sequester" of 2013, biophotonics companies are optimistic and see opportunity. This was evident across the exhibit hall at both the BiOS and Photonics West expos. A good example is the fact that Texas Instruments (TI; Dallas, TX) has identified biomedicine as a key application domain for its DLP technology, which it says can reduce size and cost for biospectroscopy and improve accuracy ...

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      Mentions: NKT Photonics Leica
    9. Deep-Tissue Dysplasia Detection with Real-Time Subcellular Analysis

      Deep-Tissue Dysplasia Detection with Real-Time Subcellular Analysis

      Angle-resolved low coherence interferometry (a/LCI) directly measures diagnostically relevant sub-cellular features in epithelial tissues up to 500 μm below the surface. Unlike optical coherence tomography (OCT), which requires image interpretation, a/LCI performs analysis of tissue and delivers to the physician direct confirmation of precancerous disease. Because it offers the greatest opportunity for successful intervention and therapy, a key weapon in the fight against cancer is early detection. If disease can be found in the precancerous stage, before abnormal cells have had the chance to spread throughout the body, the efficacy of treatment can be quite high. The clinical ...

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      Mentions: FDA Oncoscope
    10. Driving OCT into Dentistry

      Driving OCT into Dentistry

      The first international symposium on optical coherence tomography (OCT) in dentistry highlighted the many advantages of optical diagnostics over current "gold standard" technologies, including improved safety and earlier detection of decay. Stakeholders are now taking steps that will help this modality take root—and eventually improve patient outcomes. Considering the safety concerns associated with x-rays, newer optical diagnostics are particularly valuable in cases where frequent monitoring improves patient outcomes. Dentistry is one such case, and attendees at the first international Symposium on Optical Coherence Tomography (OCT) in Dentistry (June 20–21, 2013; Tokyo, Japan) came away with substantive evidence of ...

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    11. Encouraging entrepreneurship in biophotonics

      Encouraging entrepreneurship in biophotonics

      There were many good lessons for entrepreneurs and their supporters at the 2013 Massachusetts Medical Device Industry Council's (MassMEDIC's) MedTech Investors Conference (November 1, 2013; Boston, MA). Education was a theme that began with the location of the event—the University of Massachusetts (UMass) Boston—and the opening address by UMass president Robert L. Caret, Ph.D. "Elected officials need to be reminded that an educated workforce is critical," said Caret, who was happy to report that the UMass system has boosted by more than 50% education in science, technology, engineering, and mathematics (STEM) disciplines since 2007. He ...

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      Tissue phantoms are useful as instrument-design aids, as tools for helping buyers compare different systems, and as training resources for helping personnel—from clinicians to trade-show demonstrators—to learn proper system operation without requiring human subjects. Standard, well-characterized "test eyes" are available for a range of ophthalmic instruments—and now, at last, for use with optical coherence tomography (OCT) systems. In the field of ophthalmology , standard, well-characterized "test eyes" (tissue phantoms) are generally available to enable development and comparison of diagnostic instruments. The corneal topographer, the refractometer, and, more recently, the wavefront aberrometer all have the benefit of readily available ...

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      Mentions: UC Davis
    13. Esophageal Imaging with Next-gen OCT

      Esophageal Imaging with Next-gen OCT

      Having already revolutionized ophthalmology, optical coherence tomography (OCT) is about to be introduced to the field of gastroenterology. The approach provides noninvasive and comprehensive depth imaging to improve the detection of esophageal cancer, and hopes to enable screening in addition to assessment. The ability of optical coherence tomography (OCT) to perform non-contact, high-resolution, cross-sectional imaging in real time enabled the technique to revolutionize the field of ophthalmology. 1,2 Although relatively new, OCT has become the gold standard for the diagnosis and treatment of debilitating eye diseases. It is now also being used to image coronary arteries, lungs, skin, bladder ...

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    14. Swanson inspires with OCT review at Laser Marketplace Seminar

      Swanson inspires with OCT review at Laser Marketplace Seminar

      In his presentation on optical coherence tomography (OCT) during the 2013 Laser Marketplace Seminar (at Photonics West), Eric Swanson , serial entrepreneur and publisher of OCTnews , provided a comprehensive tour of OCT applications and implementations -- the vast majority of them biomedical. Swanson is a fantastic spokesperson for OCT thanks not only to his pioneering role in its development, but also to his tracking and analysis of its progress. For instance, he outlined the ROI of government support for OCT by discussing the technology's impact on the economy in terms of dollars and jobs, and on patient care (one OCT scan ...

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    15. Novel ophthalmic imaging with adaptive optics, confocal imaging, and OCT

      Novel ophthalmic imaging with adaptive optics, confocal imaging, and OCT

      A bio-optics triple-threat—a combination of adaptive optics, optical coherence tomography, and confocal microscopy—allows imaging of the human eye with unprecedented detail. It promises to enable more accurate clinical analysis for detection of diseases such as macular degeneration and glaucoma, with the ultimate goal of reducing blindness. The human eye is complex and powerful, but extremely vulnerable—far more susceptible than any other organ to ailments via blunt force, bacterial infection, and exposure. While researchers have developed numerous innovations for the detection and treatment of these conditions, there is still plenty of opportunity to enhance ophthalmic diagnostic and treatment ...

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    16. Grant for students supports OCT-related travel expenses

      Grant for students supports OCT-related travel expenses
      OCT News, in collaboration with Sensors Unlimited – Goodrich ISR Systems (Princeton, NJ), has launched its annual Student Travel Grant Awards program, which assists students with travel expenses for optical coherence tomography (OCT)-related conferences or meetings, according to publisher Eric Swanson. Such conferences and meetings include SPIE BiOS/Photonics West in San Francisco, CA (this year's will be held January 21–26). Zhao Wang is one of four student applicants who qualify for the $1,000 travel award this year, based on judges’ scores for technical merit, clarity, and novelty in the field of OCT. Working with Dr. Andrew ...
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    17. OPTICAL COHERENCE TOMOGRAPHY/BIOIMAGING: One decade and $500M: The impact of federal funding on OCT - Part 2

      OPTICAL COHERENCE TOMOGRAPHY/BIOIMAGING: One decade and $500M: The impact of federal funding on OCT - Part 2
      EDITOR'S NOTE: This article is the follow-up article to "One decade and $500M: The impact of federal funding on OCT—Part 1," which appears in the September/October 2011 issue of BioOptics World. Over the past decade, governments around the world have invested hundreds of millions of dollars in research and development involving optical coherence tomography (OCT). Part Two of this two-part article explores the return on that investment in terms of product and economic growth in the for-profit sector. By Eric A. Swanson As discussed in Part 1 of this article, determining the impact of research dollars for ...
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    18. Optical Coherence Tomography/Bioimaging: One decade and $500M: The impact of federal funding on OCT—Part 1

      Optical Coherence Tomography/Bioimaging: One decade and $500M: The impact of federal funding on OCT—Part 1
      Over the past decade, governments around the world have invested hundreds of millions of dollars in research and development involving optical coherence tomography (OCT). Part One of this two-part article explores where the money has come from, and where it has gone, and begins to uncover the return on that investment—which will be further explored in Part Two.
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    19. BioOptics World Editors Column: Vitality all around

      BioOptics World Editors Column: Vitality all around
      We’re pleased this issue to publish the first of a two-part article by Eric Swanson, a pioneer in optical coherence tomography (OCT), that discusses government investment in OCT as well as the return on that investment—in terms of diagnostics, patient outcomes. and research in multiple disciplines; plus job creation, revenue generation and other economic measures (see p. 30). This year OCT is celebrating its 20th anniversary, and since Swanson penned his article the technology has seen some interesting developments, including demonstration for the first time of the ability to reliably determine risk of pancreatic cancer, and European CE ...
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    20. Optical coherence tomography market grows into new phase

      JANUARY 5, 2010--"The market for OCT systems is entering a new phase as it moves beyond ophthalmology and is applied to new medical specialties," reports a new market research study by Strategies Unlimited (Mountain View, CA). Titled OCT 2010: Technology, Applications, and Markets, the report says that despite the dismal 2009 economy, sales of optical coherence tomography (OCT) systems grew to $315 million, and a compound annual growth rate of 20% is expected through 2014. The report is an update to the first study ever to quantify the OCT market. OCT systems use advanced optical techniques to construct micron-scale ...
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    21. Bio-optics: Everywhere at once

      Bio-optics watchers must be in multiple places simultaneously each autumn in order to experience first hand all the exciting work being reported at so many events. Besides BioOpto Japan and the World Molecular Imaging Congress (see reports starting on page 9) this fall’s schedule included the NIH/SPIE Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Bedside (October 1–2, Bethesda, MD) which focused on work to transition optical methods from the lab to clinical settings. Doug Malchow of Goodrich-Sensors Unlimited attended with a specific interest in optical coherence tomography (OCT), and said, “It was truly ...
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    22. Japanese research focus of BioOpto Japan

      Japanese research focus of BioOpto Japan

      The inaugural BioOpto Japan (September 16–17, Yokohama) was held in conjunction with LED Japan Conference & Expo/Strategies in Light and OITDA 2009; together the events drew 7132 people. The three shared a seamless exhibits layout, and the BioOpto conference (see Fig. 1), which featured biomedical optics researchers from all over Japan, was set up right in the exhibit hall. The Japanese-language conference covered topics such as photodynamic therapy (PDT; Prof. Tsunenori Arai of Keio University), medical application of hollow optical fiber (Prof. Yuji Matsuura of Tohoku University), orange fiber lasers (Kasunobu Kojima of Nidek Co. Ltd), optical coherence tomography ...

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      Mentions: Thorlabs Nidek NTT
    23. IMAGING FOR OPHTHALMOLOGY: OCT explorations pervade ARVO/ISIE annual meeting

      At the annual meeting of the Association for Research in Vision and Ophthalmology/International Society for Imaging in the Eye (ARVO/ISIE; www.arvo.org; see www.bioopticsworld.com/articles/327003), 20 of the 24 presentations mentioned optical coherence tomography (OCT) in their titles. So did three posters–and nearly all of the other presentations referred to OCT. The event, held May 1 and 2 in Ft. Lauderdale, FL, attracted more than 140 of the world’s leading experts in ophthalmic imaging. The meeting’s goal is to present clinical and basic science advances in glaucoma, retina, cornea, anterior segment ...
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