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    1. OCT Developments Address Skin

      OCT Developments Address Skin

      Recent developments in optical coherence tomography (OCT) address skin cancer diagnosis. MedLumics (Madrid, Spain) has launched a three-year initiative to translate research into new clinical applications—with help from $4.9 million (€3.6 million) in Series A funding from EU joint investors. Called the BiopsyPen Project, the initiative is led by MedLumics and the Medical University of Vienna (Austria), along with European members including VTT Finland (Espoo, Finland), Delft University of Technology in The Netherlands, Exalos (Schlieren, Switzerland), the Polytechnic University of Madrid, and Optocap (Livingston, Scotland). The organizations are working to develop a handheld system for point-of-care diagnosis ...

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    2. Life sciences seen as key at SPIE Photonics West '14

      Life sciences seen as key at SPIE Photonics West '14

      Again and again at SPIE Photonics West 2014 (February 1–6), I found evidence of the importance of life sciences applications among optics and photonics suppliers and systems developers. Despite setbacks imposed by the U.S. government's "sequester" of 2013, biophotonics companies are optimistic and see opportunity. This was evident across the exhibit hall at both the BiOS and Photonics West expos. A good example is the fact that Texas Instruments (TI; Dallas, TX) has identified biomedicine as a key application domain for its DLP technology, which it says can reduce size and cost for biospectroscopy and improve accuracy ...

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    3. Deep-Tissue Dysplasia Detection with Real-Time Subcellular Analysis

      Deep-Tissue Dysplasia Detection with Real-Time Subcellular Analysis

      Angle-resolved low coherence interferometry (a/LCI) directly measures diagnostically relevant sub-cellular features in epithelial tissues up to 500 μm below the surface. Unlike optical coherence tomography (OCT), which requires image interpretation, a/LCI performs analysis of tissue and delivers to the physician direct confirmation of precancerous disease. Because it offers the greatest opportunity for successful intervention and therapy, a key weapon in the fight against cancer is early detection. If disease can be found in the precancerous stage, before abnormal cells have had the chance to spread throughout the body, the efficacy of treatment can be quite high. The clinical ...

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    4. Driving OCT into Dentistry

      Driving OCT into Dentistry

      The first international symposium on optical coherence tomography (OCT) in dentistry highlighted the many advantages of optical diagnostics over current "gold standard" technologies, including improved safety and earlier detection of decay. Stakeholders are now taking steps that will help this modality take root—and eventually improve patient outcomes. Considering the safety concerns associated with x-rays, newer optical diagnostics are particularly valuable in cases where frequent monitoring improves patient outcomes. Dentistry is one such case, and attendees at the first international Symposium on Optical Coherence Tomography (OCT) in Dentistry (June 20–21, 2013; Tokyo, Japan) came away with substantive evidence of ...

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    5. Encouraging entrepreneurship in biophotonics

      Encouraging entrepreneurship in biophotonics

      There were many good lessons for entrepreneurs and their supporters at the 2013 Massachusetts Medical Device Industry Council's (MassMEDIC's) MedTech Investors Conference (November 1, 2013; Boston, MA). Education was a theme that began with the location of the event—the University of Massachusetts (UMass) Boston—and the opening address by UMass president Robert L. Caret, Ph.D. "Elected officials need to be reminded that an educated workforce is critical," said Caret, who was happy to report that the UMass system has boosted by more than 50% education in science, technology, engineering, and mathematics (STEM) disciplines since 2007. He ...

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    6. OPTICAL COHERENCE TOMOGRAPHY/TISSUE PHANTOMS: A physical eye model for OCT

      OPTICAL COHERENCE TOMOGRAPHY/TISSUE PHANTOMS: A physical eye model for OCT

      Tissue phantoms are useful as instrument-design aids, as tools for helping buyers compare different systems, and as training resources for helping personnel—from clinicians to trade-show demonstrators—to learn proper system operation without requiring human subjects. Standard, well-characterized "test eyes" are available for a range of ophthalmic instruments—and now, at last, for use with optical coherence tomography (OCT) systems. In the field of ophthalmology , standard, well-characterized "test eyes" (tissue phantoms) are generally available to enable development and comparison of diagnostic instruments. The corneal topographer, the refractometer, and, more recently, the wavefront aberrometer all have the benefit of readily available ...

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    7. Esophageal Imaging with Next-gen OCT

      Esophageal Imaging with Next-gen OCT

      Having already revolutionized ophthalmology, optical coherence tomography (OCT) is about to be introduced to the field of gastroenterology. The approach provides noninvasive and comprehensive depth imaging to improve the detection of esophageal cancer, and hopes to enable screening in addition to assessment. The ability of optical coherence tomography (OCT) to perform non-contact, high-resolution, cross-sectional imaging in real time enabled the technique to revolutionize the field of ophthalmology. 1,2 Although relatively new, OCT has become the gold standard for the diagnosis and treatment of debilitating eye diseases. It is now also being used to image coronary arteries, lungs, skin, bladder ...

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    8. Dr. Michael Leitner will Give Webcast on Non-Medical Applications of OCT April 11th, 2013

      Dr. Michael Leitner will Give Webcast on Non-Medical Applications of OCT April 11th, 2013

      In this webcast, Dr. Michael Leitner, head of the optical coherence tomography group at RECENDT - Research Center for Non Destructive Testing GmbH (Linz, Austria) discusses the application of OCT as a tool for microstructure analysis, device characterization, and quality control in materials science and industry.

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    9. Swanson inspires with OCT review at Laser Marketplace Seminar

      Swanson inspires with OCT review at Laser Marketplace Seminar

      In his presentation on optical coherence tomography (OCT) during the 2013 Laser Marketplace Seminar (at Photonics West), Eric Swanson , serial entrepreneur and publisher of OCTnews , provided a comprehensive tour of OCT applications and implementations -- the vast majority of them biomedical. Swanson is a fantastic spokesperson for OCT thanks not only to his pioneering role in its development, but also to his tracking and analysis of its progress. For instance, he outlined the ROI of government support for OCT by discussing the technology's impact on the economy in terms of dollars and jobs, and on patient care (one OCT scan ...

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    10. Novel ophthalmic imaging with adaptive optics, confocal imaging, and OCT

      Novel ophthalmic imaging with adaptive optics, confocal imaging, and OCT

      A bio-optics triple-threat—a combination of adaptive optics, optical coherence tomography, and confocal microscopy—allows imaging of the human eye with unprecedented detail. It promises to enable more accurate clinical analysis for detection of diseases such as macular degeneration and glaucoma, with the ultimate goal of reducing blindness. The human eye is complex and powerful, but extremely vulnerable—far more susceptible than any other organ to ailments via blunt force, bacterial infection, and exposure. While researchers have developed numerous innovations for the detection and treatment of these conditions, there is still plenty of opportunity to enhance ophthalmic diagnostic and treatment ...

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    11. Grant for students supports OCT-related travel expenses

      Grant for students supports OCT-related travel expenses
      OCT News, in collaboration with Sensors Unlimited – Goodrich ISR Systems (Princeton, NJ), has launched its annual Student Travel Grant Awards program, which assists students with travel expenses for optical coherence tomography (OCT)-related conferences or meetings, according to publisher Eric Swanson. Such conferences and meetings include SPIE BiOS/Photonics West in San Francisco, CA (this year's will be held January 21–26). Zhao Wang is one of four student applicants who qualify for the $1,000 travel award this year, based on judges’ scores for technical merit, clarity, and novelty in the field of OCT. Working with Dr. Andrew ...
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    12. OPTICAL COHERENCE TOMOGRAPHY/BIOIMAGING: One decade and $500M: The impact of federal funding on OCT - Part 2

      OPTICAL COHERENCE TOMOGRAPHY/BIOIMAGING: One decade and $500M: The impact of federal funding on OCT - Part 2
      EDITOR'S NOTE: This article is the follow-up article to "One decade and $500M: The impact of federal funding on OCT—Part 1," which appears in the September/October 2011 issue of BioOptics World. Over the past decade, governments around the world have invested hundreds of millions of dollars in research and development involving optical coherence tomography (OCT). Part Two of this two-part article explores the return on that investment in terms of product and economic growth in the for-profit sector. By Eric A. Swanson As discussed in Part 1 of this article, determining the impact of research dollars for ...
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    13. Optical Coherence Tomography/Bioimaging: One decade and $500M: The impact of federal funding on OCT—Part 1

      Optical Coherence Tomography/Bioimaging: One decade and $500M: The impact of federal funding on OCT—Part 1
      Over the past decade, governments around the world have invested hundreds of millions of dollars in research and development involving optical coherence tomography (OCT). Part One of this two-part article explores where the money has come from, and where it has gone, and begins to uncover the return on that investment—which will be further explored in Part Two.
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    14. BioOptics World Editors Column: Vitality all around

      BioOptics World Editors Column: Vitality all around
      We’re pleased this issue to publish the first of a two-part article by Eric Swanson, a pioneer in optical coherence tomography (OCT), that discusses government investment in OCT as well as the return on that investment—in terms of diagnostics, patient outcomes. and research in multiple disciplines; plus job creation, revenue generation and other economic measures (see p. 30). This year OCT is celebrating its 20th anniversary, and since Swanson penned his article the technology has seen some interesting developments, including demonstration for the first time of the ability to reliably determine risk of pancreatic cancer, and European CE ...
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    15. Optical coherence tomography market grows into new phase

      JANUARY 5, 2010--"The market for OCT systems is entering a new phase as it moves beyond ophthalmology and is applied to new medical specialties," reports a new market research study by Strategies Unlimited (Mountain View, CA). Titled OCT 2010: Technology, Applications, and Markets, the report says that despite the dismal 2009 economy, sales of optical coherence tomography (OCT) systems grew to $315 million, and a compound annual growth rate of 20% is expected through 2014. The report is an update to the first study ever to quantify the OCT market. OCT systems use advanced optical techniques to construct micron-scale ...
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    16. Bio-optics: Everywhere at once

      Bio-optics watchers must be in multiple places simultaneously each autumn in order to experience first hand all the exciting work being reported at so many events. Besides BioOpto Japan and the World Molecular Imaging Congress (see reports starting on page 9) this fall’s schedule included the NIH/SPIE Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Bedside (October 1–2, Bethesda, MD) which focused on work to transition optical methods from the lab to clinical settings. Doug Malchow of Goodrich-Sensors Unlimited attended with a specific interest in optical coherence tomography (OCT), and said, “It was truly ...
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    17. Japanese research focus of BioOpto Japan

      Japanese research focus of BioOpto Japan

      The inaugural BioOpto Japan (September 16–17, Yokohama) was held in conjunction with LED Japan Conference & Expo/Strategies in Light and OITDA 2009; together the events drew 7132 people. The three shared a seamless exhibits layout, and the BioOpto conference (see Fig. 1), which featured biomedical optics researchers from all over Japan, was set up right in the exhibit hall. The Japanese-language conference covered topics such as photodynamic therapy (PDT; Prof. Tsunenori Arai of Keio University), medical application of hollow optical fiber (Prof. Yuji Matsuura of Tohoku University), orange fiber lasers (Kasunobu Kojima of Nidek Co. Ltd), optical coherence tomography ...

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      Mentions: Thorlabs Nidek NTT
    18. IMAGING FOR OPHTHALMOLOGY: OCT explorations pervade ARVO/ISIE annual meeting

      At the annual meeting of the Association for Research in Vision and Ophthalmology/International Society for Imaging in the Eye (ARVO/ISIE; www.arvo.org; see www.bioopticsworld.com/articles/327003), 20 of the 24 presentations mentioned optical coherence tomography (OCT) in their titles. So did three posters–and nearly all of the other presentations referred to OCT. The event, held May 1 and 2 in Ft. Lauderdale, FL, attracted more than 140 of the world’s leading experts in ophthalmic imaging. The meeting’s goal is to present clinical and basic science advances in glaucoma, retina, cornea, anterior segment ...
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    19. Multibeam OCT scanner for skin imaging by Michelson Diagnostics

      The VivoSight Multi-Beam OCT (optical coherence tomography) scanner uses the high resolution capability of Michelson Diagnostics Ltd.'s (MDL) proprietary technology to image skin and other surface tissue with a hand-held probe. The compact, ergonomically designed probe promises an isotropic resolution of better than 10 microns to a depth of up to 2 mm. Scan rates vary from 6.5 fps to 35 fps depending on scan width, which, in turn, can be varied up to 5 mm.
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    20. Ultra broadband coherent light source for optical coherence tomography applications from Femtolasers

      Ultra broadband coherent light source for optical coherence tomography applications from Femtolasers
      Integral OCT is the third generation of Femtolasers' (Vienna, Austria) compact ultra broadband coherent light source for applications including ultra high-resolution optical coherence tomography (OCT), imaging of individual cells and sub-cellular structures, ultra high-speed 3D OCT, spectroscopic OCT, polarization-sensitive OCT, and spectrally encoded endoscopy. The device supports video rate 2D and 3D volume scans at ultra-high resolution.
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    21. Fujimoto outlines OCT progress, opportunity during Hounsfield memorial prize ceremony

      MIT professor and optical coherence tomography (OCT) pioneer James Fujimoto became the fifth annual Hounsfield memorial lecturer at the UK's Imperial College London Imaging Sciences Centre earlier this month. The annual event, designed to recognize the contribution of Sir Godfrey Hounsfield to medical imaging, is meant to showcase a world-leading researcher and review developments in imaging science. As part of the event, Fujimoto was presented with the 2009 Hounsfield medal.
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    22. Quantum OCT images biological sample

      For the first time, quantum optical coherence tomography (QOCT)1 has been proved viable for imaging biological samples. M. Boshra Nasr, a postdoctoral researcher in Boston University’s Quantum Imaging Laboratory led the work that has produced the first such experimental QOCT images. The approach is appealing because, unlike classical OCT, QOCT is inherently immune to group-velocity dispersion (GVD), which degrades the axial resolution. This immunity is a result of the frequency entanglement inhe
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    23. Study shows benefit of confocal laser endomicroscopy for urology

      APRIL 27, 2009--According to new data presented today at the American Urological Association's (AUA) Annual meeting, real-time, in vivo confocal endomicroscopy may help urologists to differentiate low and high-grade bladder tumors from normal bladder tissue. Mauna Kea Technologies' (Paris, France) Cellvizio probe-based confocal laser endomicroscopy (pCLE) system, which provides live images of internal human tissues at the cellular level, is the subject of the work.
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    24. Cardiac imaging and OCT's legal mess

      "Word is getting out” about imaging tools that enable more precise guidance during heart surgery, said Volcano Corp. VP Joe Burnett, referring to the increased number of imaging-related presentations at the recent American College of Cardiology (ACC) Annual Meeting 2009.) Speaking at the conference, former ACC President Pamela Douglas, M.D. said that imaging is growing faster than all other procedures, services and diagnostic tests
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