BioOptics World editor-in-chief Barbara Goode inteviews Jon Holmes of Michelson Diagnostics, which produces an optical coherence tomography (OCT) system that aids clinical treatment of precancerous lesions and non-melanoma skin cancer.
Spectroscopic optical coherence tomography (SOCT) and variations such as Raman spectroscopic OCT (RS-OCT) often use absorption contrast agents such as gold nanoparticles to enhance diagnostics; however, these particles require modification to be compatible with infrared (IR) illumination. The light sources can also limit analysis of many biological components that absorb in the visible region. An alternative technique from Duke University (Durham, NC) researchers called molecular imaging true-color spectroscopic (METRiCS) OCT uses a broadband laser source (centered in the visible spectrum) and a dual-window (DW) data-processing method that improves imaging when using various IR and visible absorption contrast agents, simultaneously improving ...
Random lasers may have a future in imaging. A team at Yale University (New Haven, CT) who last year made random lasers with low spatial coherence has now used those low-coherence lasers for speckle-free imaging. The demonstration could open the door to new laser applications in biological imaging, picoprojectors, and cinema projectors. A byproduct of coherence, laser speckle is a shifting pattern of bright and dark zones produced when a laser beam passes through a scattering medium. It’s tolerable in many laser applications, but speckle degrades images recorded in laser light or displayed by laser projectors. “Speckle is a ...
Optical coherence tomography (OCT) is a non-invasive imaging technique allowing fast and high-quality two- and three dimensional imaging of semi-transparent and turbid media. So far, biomedical research and diagnostics have been the main driving forces for the reported applications and progress in OCT. However, the characteristics of OCT, specifically the ability to provide high-resolution images and depth-resolved information also in strongly scattering media in a contact-free and non destructive way, render this technique also attractive for a broad spectrum of research topics and applications outside the biomedical field. In this webcast, Dr. Michael Leitner, head of the optical coherence tomography ...
By combining digital holography with optical coherence tomography (OCT) in a process known as holoscopy, 3D parallel image acquisition with extremely high data throughput at high imaging speeds is possible due to the lack of moving elements.
