1. Articles from Termedia

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    1. Diagnostic accuracy of reflectance confocal microscopy for pigmented skin lesions presenting dermoscopic features of cutaneous melanoma

      Diagnostic accuracy of reflectance confocal microscopy for pigmented skin lesions presenting dermoscopic features of cutaneous melanoma

      Introduction The incidence and mortality of melanoma are rising rapidly. Despite ongoing research and the introduction of new therapeutic methods, advanced melanoma is still considered incurable. Early detection and surgical excision of the tumor increases patients’ survival. Since the diagnostic protocol includes surgical excision of all suspicious lesions, it is burdened with a high rate of unnecessary excisions that cause unwanted scarring. This is why the development of accurate diagnostic techniques is crucial. The most common diagnostic tool in early diagnosis of cutaneous melanoma is dermoscopy, though there are emerging new techniques, such as reflectance confocal microscopy and optical coherence ...

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    2. Optical coherence tomography versus intravascular ultrasound for culprit lesion assessment in patients with acute myocardial infarction

      Optical coherence tomography versus intravascular ultrasound for culprit lesion assessment in patients with acute myocardial infarction

      Introduction In patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) the implanted stent may not fully cover the whole intravascular ultrasound (IVUS)-derived thin-cap fibroatheroma (TCFA) related to the culprit lesion (CL). Aim Whether this phenomenon is more pronounced when optical coherence tomography (OCT) assessment of the CL is performed is not known. Material and methods Thus, we aimed to assess CLs in 40 patients with AMI treated with PCI, using VH (virtual histology)-IVUS and OCT before and after intervention. The results were blinded to the operator and PCI was done under angiography guidance. Results ...

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    3. Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study

      Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study

      Introduction Periprocedural myocardial necrosis, which can range from a low level elevation of cardiac biomarkers to a large myocardial infarction (MI), is a common complication after percutaneous coronary intervention (PCI). Aim We hypothesized that insulin-like growth factor-1 (IGF-1) levels may play a protective role in myocardial injury after coronary stent placement and aimed to investigate the relationship between IGF-1 levels and plaque characteristics assessed by optical coherence tomography (OCT). Material and methods Between May 2015 and December 2015 we prospectively enrolled 74 patients with stable angina pectoris in whom single de novo coronary artery stenosis was present. PCI was performed ...

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    4. Short-term healing response after implantation of the thin-strut, fast-releasing sirolimus-eluting biodegradable polymer-coated Alex Plus stent: optical coherence tomography study

      Short-term healing response after implantation of the thin-strut, fast-releasing sirolimus-eluting biodegradable polymer-coated Alex Plus stent: optical coherence tomography study

      Introduction Technological improvements in drug-eluting stents (DES) have led to drastic reductions in restenosis and acute stent thrombosis rates. However, chronic inflammation and late and very late stent thrombosis, particularly with the first generation durable polymer DES (DP-DES), prompted the development of new DES platforms that use biodegradable polymers. The advantage of biodegradable polymers relies on the resorbable property of these polymers, reducing in this way the polymer-induced chronic inflammation and related clinical events such as restenosis and stent thrombosis. Notwithstanding , despite the theoretical advantages of bioabsorbable polymer DES (BP-DES), there are limited data focused on its very early vascular ...

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    5. Optical coherence tomography guided successful fibrinolytic treatment without the need for percutaneous coronary intervention in a patient with acute ST-segment elevation myocardial infarction

      Optical coherence tomography guided successful fibrinolytic treatment without the need for percutaneous coronary intervention in a patient with acute ST-segment elevation myocardial infarction

      A 36-year-old woman was admitted to the coronary care unit with a diagnosis of myocardial infarction with ST-segment elevation (STEMI) after an hour of chest pain. She was a smoker and she had no history of any other atherosclerotic risk factors. She had a stable haemodynamic status without signs of heart failure. An electrocardiogram was obtained, revealing ST-segment elevation in anterior leads and reciprocal changes in inferior leads. Given the ST-segment elevation in the context of new-onset chest pain, she was given 7500 IU of unfractionated heparin, 300 mg of aspirin, and 600 mg of clopidogrel and taken immediately for ...

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    6. Optical coherence tomography improves the results of balloon pulmonary angioplasty in inoperable chronic thrombo-embolic pulmonary hypertension

      Optical coherence tomography improves the results of balloon pulmonary angioplasty in inoperable chronic thrombo-embolic pulmonary hypertension

      A 71-year-old woman with non-operable, peripheral type chronic thrombo-embolic pulmonary hypertension (CTEPH) and with World Health Organisation (WHO) class III dyspnoea was admitted to our department for balloon pulmonary angioplasty (BPA). Right heart catheterisation confirmed pulmonary hypertension (mean pulmonary artery pressure (mPAP) 37 mm Hg, mean right atrial pressure (mRAP) 6 mm Hg, pulmonary capillary wedge pressure (PCWP) 13 mm Hg, pulmonary vascular resistance (PVR) 214 dyn · s · cm–5 and cardiac Index (CI) 4.1 l/min · m2 ) and pulmonary scintigraphy showed multiple segmental perfusion defects (segments 1, 2, 8, 9 in the left lung and 2, 3, 4 ...

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      Mentions: Abbot
    7. Very, very late stent thrombosis triggered by in-stent neoatherosclerosis: optical coherence tomography findings

      Very, very late stent thrombosis triggered by in-stent neoatherosclerosis: optical coherence tomography findings

      A 64-year-old woman with dyslipidemia, hypertension and type 2 diabetes plus an existing 4.0-mm × 28-mm bare-metal stent (BMS; Multilink Penta, Abbott Vascular, US) deployed over 10 years ago in the right coronary artery (RCA) was admitted to our emergency department with inferolateral and posterior ST-segment elevation acute myocardial infarction. Coronary angiography showed occlusion and thrombotic plaque in the mid RCA at the site of the prior stent implantation. After thrombectomy, optical coherence tomography (OCT) documented the presence of in-stent neoatherosclerosis with lipid-laden plaque, mild calcification, clustered macrophages and a disrupted thin-cap fibroatheroma (TCFA), a pattern similar to the morphology ...

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    8. Association between inflammatory biomarkers and thin-cap fibroatheroma detected by optical coherence tomography in patients with coronary heart disease

      Association between inflammatory biomarkers and thin-cap fibroatheroma detected by optical coherence tomography in patients with coronary heart disease

      Introduction : The relationship between plaque morphology detected by optical coherence tomography (OCT) and inflammatory biomarkers is not well known. Material and methods : This study included 47 patients with ischemic heart disease (22 patients with acute coronary syndrome and 25 patients with effort angina pectoris) who underwent percutaneous coronary intervention (PCI). Before PCI, peripheral blood levels of the inflammatory biomarkers high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were measured. The OCT can detect thin-cap fibroatheroma (TCFA), a lesion with high potential for adverse cardiac events. We investigated the relationships between TCFAs in culprit lesions detected by OCT and the peripheral blood ...

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    9. The basics of intravascular optical coherence tomography

      The basics of intravascular optical coherence tomography

      Optical coherence tomography (OCT) has opened new horizons for intravascular coronary imaging. It utilizes near-infrared light to provide a microscopic insight into the pathology of coronary arteries in vivo . Optical coherence tomography is also capable of identifying the chemical composition of atherosclerotic plaques and detecting traits of their vulnerability. At present it is the only tool to measure the thickness of the fibrous cap covering the lipid core of the atheroma, and thus it is an exceptional modality to detect plaques that are prone to rupture (thin fibrous cap atheromas). Moreover, it facilitates distinguishing between plaque rupture and plaque erosion ...

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    10. Optical coherence tomography diagnostics for onco–urology. Review of clinical perspectives

      Optical coherence tomography diagnostics for onco–urology. Review of clinical perspectives

      Introduction. Optical coherence tomography (OCT) is being investigated widely for use in urologic pathology. The current imaging of urogenital cancers cannot be perfect, thus, routine methods demands new updates or inventions of alternative radiological scope. OCT presents so–called “live” optical biopsy. The authors aim to review this modality for uro–oncological purposes. Matherial and methods. A series of 37 publications between 1989 and 2012 was selected and cited from GoogleScholar and PubMED/MEDLINE. The urogenital tract (bladder, ureter, scrotum organs and prostate) was imaged by OCT. Results. The overall OCT sensitivity, specificity, accuracy, negative and positive predictive values ranged ...

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    11. From industrial laboratory directly to operating table: the vicissitudes of optical coherence tomography (OCT)

      From industrial laboratory directly to operating table: the vicissitudes of optical coherence tomography (OCT)

      The current issue of the CEJU runs a paper presenting the prospect of an amazing, unconventional diagnostic method. Optical coherence tomography (OCT) is a relatively new interferometric technique of optical imaging [1]. Though physical foundations of OCT are difficult to grasp for a run–of–the–mill kind of CEJU reader (editor alike), Dr. S. Kharchenko and co–workers’ paper deserves our notice. This technique has been developed in the Massachusetts Institute of Technology twenty years ago and now OCT emerges as a powerful supplementary tool for uro–oncology. We can be really moved by amazing 3–D scans of ...

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    1-11 of 11
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