There is provided a method of identifying a region of interest in sample. The method comprises obtaining one or more optical coherence tomography (OCT) axial scans at one or more locations over the sample surface; for each axial scan, determining an integrated total of OCT intensity over the depth of the scan, and determining an attenuation depth into the sample at which a predetermined fraction of the integrated total is reached; and determining from the one or more attenuation depths a region of interest in the sample. Generally, the method does not rely the accuracy (or inaccuracy) of any particular ...

A spectrometer is presented that includes s spectrally dispersive optical element (120) to spectrally disperse a received light, a leveraged-optics adjustable deflector (142-1, 142-2, 142-3) to adjustably deflect the spectrally dispersed light, and a detector array (160) to receive the spectrally dispersed and adjustably deflected light. The received light can inlcude an interference beam combined from a returned image beam and a reference beam in a Spectral Domain Optical Coherence Tomograph. The detector array can include a linear sensor array. The leveraged-optics adjustable deflector can include an optical element with an adjustable transmissive property or an adjustable reflective property, wherein ...

Apparatus for irradiating a sample, comprising an interferometer forwarding an electromagnetic radiation and a sample arm receiving the electromagnetic radiation, wherein the sample arm includes an arrangement which is configured to produce at least two radiations from the electromagnetic radiation so as to irradiate the sample, and to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.

Provided is an optical imaging system which visualizes a deep portion of a scattering target. To this end, the optical imaging system is adapted such that signals resulting from beams of light reflected on the surface of and scattered once in the surface of a target being inspected are removed from signals obtained by using an optical system similar to an optical coherence tomography system, thereby extracting a signal resulting from beams of light produced by multiple scattering to image the target.

The invention relates to the field of ophthalmology and serves for displaying the anterior and posterior portions of the eye, in particular the whole eye, wherein the displays are preferably based on optical coherence tomography scans. According to the invention, the eye is illuminated from a variable laser light source with a measurement range corresponding to the eye length, wherein the focus of the laser beam in the eye can be shifted laterally and/or axially by an adjustment mechanism, and the light fractions back-scattered from the sample are captured via an interferometer by a data acquisition unit and forwarded ...

A sensing system for implant surgery includes an insertion device for moving an implant into a narrow cavity in a patient's body. A sensor measures the distance from an end of the insertion device to anatomic surfaces at a distance from the end of the insertion device. An optical coherence tomography (OCT) system integrates the sensor and produces OCT images, which can be quantified to distance measurements. The system is particularly useful for cochlear implant surgery.

According to a first aspect, the invention relates to a multimodal optical sectioning microscope (200, 400, 600) for full-field imaging of a volumic and scattering sample comprising: - a full-field OCT system for providing an image of a first section in depth of the sample comprising an illumination sub-system (201, 401, 601) and a full-field imaging interferometer with a detection sub system (208, 408, 608) and an optical conjugation device for optically conjugating the sample and said detection sub system, wherein said optical conjugation device comprises a microscope objective (203, 403, 603), - a supplementary full-field optical sectioning imaging system for providing ...

The present invention relates to a full-field optical coherence tomography system (300) for imaging an object (319), comprising a light source (301), a first interferometric device having means for splitting an input light beam and comprising at least a reflecting surface (307), a second interferometric device having means for splitting the spectrally modulated output beam and comprising at least a reflecting surface, a multichannel acquisition device (321), the system (300) being characterized in that at least one of the interferometric devices includes at least a focusing optical element arranged to focus at least one of the input beams or at ...

Optical coherence tomography performs cross-sectional imaging, three-dimensional imaging, or data acquisition in materials or biological tissue by measuring the magnitude and time delay of backscattered or backreflected light from inside the sample. OCT performs imaging or measurement by directing a light beam at the sample, measuring the backscattering or backreflected signal from the sample as a function of the optical delay (known as an axial scan or A-scan), and scanning the OCT beam incident on the tissue or material to generate a two or three dimensional dataset which represents cross-sectional or volumetric information about the internal structure of the sample ...

An OCT image of an eye which has been subject to a DSAEK corneal transplant, in which a Descement's membrane in the cornea has been replaced by a graft, is processed to identify the outline of the graft. The process includes the steps of: computationally extracting the boundary of the cornea including the graft; computationally detecting the corners of the graft; computationally extracting points on the boundary between the graft and the original cornea; and computationally fitting the points on the boundary between the graft and the original cornea smoothly into a curve. The outline of the graft is ...

A method of and determining the extent of a structure (1), such as a non- melanoma skin cancer, in or on the skin of a subject, the method comprising the steps of: placing an index marker (3) on the skin adjacent to the structure (1); positioning an optical coherence tomography device (8) relative to the index marker; using the optical coherence tomography device (8) to image the structure (1) so as to create an image of a cross- section through the skin determining the position of an edge of the structure (1) in the image; and translating that position of ...

An optical coherence tomography (OCT) uses an active mode-locking fiber laser in order to obtain image information of a sample. An imaging device of the present invention comprises: a light source unit that emits light having a central wavelength which is periodically changed by a modulation signal received from the inside of a resonator; a light separation unit that separates the light having a single path, which is emitted from the light source unit, into a first light and a second light having different paths; a reference unit that is disposed on a path through which the first light separated ...

Systems for imaging a sample are provided. The system includes an optical coherence tomography (OCT) imaging portion having an associated OCT path defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path defined by a second set of optical elements between an image capture device and the sample, different from the OCT path; and an illuminator portion having an associated illumination path defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture ...

A method for calibrating a Fourier domain optical coherence tomography system includes receiving spectral data from an optical detector comprising a linear array of detector elements, each detector element having a position labeled n, wherein detected light was wavelength-dispersed across the linear array of detector elements; determining parameters of a preselected functional relationship between wave number, kn, corresponding to detector element n as a function of optical detector element n based on the spectral data; further receiving subsequent spectral data subsequent to the first-mentioned receiving, wherein detected light was wavelength-dispersed across the linear array of detector elements; converting the subsequent ...

An optical coherence tomography system comprising a light source (a) and a probe (e) that has a window at a front facing end. The window has an inner face (i) that has an anti-reflection surface and allows light from the source to pass through it, and an outer face (j) that reflects some of the light from the source and transmits some of the light to and from the sample (k). The reflected light acts as a reference.