Visualizing tissues and neurons inside an animal's skull has long been a challenge for biophotonics techniques, thanks to the skull's thickness and the complex structures inside. Approaches to this problem have included the use of endoscopic platforms in brain imaging, two-photon and three-photon microscopy of small animals, and for surgical purposes the creation of a transparent window in the skull itself. A team at the Institute for Basic Science ( IBS ) in Daejeon, South Korea, has now developed a new approach to tackling the optical aberrations involved in imaging through an intact skull, and tested the system on a ...

Projects from Boston and Portland could help translation of OCTA into clinics. Retina blood flow: vital for diagnosis Optical coherence tomography angiography (OCTA) is a promising technique for imaging of blood vessels, in which sequential OCT scans of the same tissue cross-section reveal the sites of blood flow within those tissues, and can allow the blood oxygen content to be calculated. Examination of the retina is one promising application area for OCTA, thanks partly to the widespread adoption of conventional OCT within ophthalmology and its established place in clinical workflows. Two recent projects have published findings that could assist the ...

Projects from Boston and Portland could help translation of OCTA into clinics. Retina blood flow: vital for diagnosis Optical coherence tomography angiography (OCTA) is a promising technique for imaging of blood vessels, in which sequential OCT scans of the same tissue cross-section reveal the sites of blood flow within those tissues, and can allow the blood oxygen content to be calculated. Examination of the retina is one promising application area for OCTA, thanks partly to the widespread adoption of conventional OCT within ophthalmology and its established place in clinical workflows. Two recent projects have published findings that could assist the ...

Several diseases of the cornea, such as corneal dystrophy and keratoconus, lead to underlying changes in a cornea's intrinsic biomechanical properties as well as the inherent cellular damage. Measuring those biomechanical markers could be a valuable tool for monitoring and detecting the diseases, especially if the technique can be a non-contact method. Non-invasive measurement methods are inherently likely to be best suited for eventual translation into clinics, and for reducing patient discomfort. Optical coherence elastography (OCE), in which optical coherence tomography is used to image tissue while it is under some form of transient local mechanical deformation and subsequent ...

Virtual conference hears that new applications and markets will likely eclipse current use of the technology in communications. PICs for life sciences Silicon photonics has “endless potential” in applications beyond its current use in telecoms and datacoms, and is likely to create major new markets as the technology migrates to different wavelength regimes. That was one of the key messages from Ghent University professor Roel Baets, in a conference presentation for this week’s SPIE Photonics Europe Digital Forum . The virtual conference is taking place this week, as a replacement for the original event planned for Strasbourg, and features more ...

EU-funded research aims to improve retinal imaging for early screening of glaucoma. Galahad in use Galahad , a Horizon 2020 research project developing an OCT platform for improved early screening of glaucoma, has successfully completed its work, according to project coordinators Gooch & Housego ( G&H ). Launched in 2016 , Galahad - from Glaucoma Advanced, LAbel-free High resolution Automated OCT Diagnostics - has now reached the end of its three-year €4-million program to develop ultra-high resolution polarization-sensitive optical coherence tomography (UHR-PS-OCT). Ten European partners made up the consortium. "Over the last 36 months the project has had a major impact on the development of UHR-PS-OCT ...

The 2020 award will support research into optical coherence elastography and its translation into clinics. Fernando Zvietcovich, Fellowship recipient The 2020 SPIE-Franz Hillenkamp Postdoctoral Fellowship will be awarded to Fernando Zvietcovich, currently a PhD candidate at the University of Rochester , who will receive the Fellowship's $75,000 prize. This annual award is intended to support interdisciplinary research in the biophotonics sector, and provide opportunities for translating new technologies into clinical practice. Zvietcovich will receive recognition during the BIOS Hot Topics session at SPIE Photonics West in San Francisco on 1st February 2020. Zvietcovich's research, conducted in conjunction with ...

Lumedica's low-cost OCT system Lumedica , the startup company spun out of co-founder Adam Wax’s Duke University research group, has won a $1 million small business innovation research (SBIR) grant to further develop its low-cost optical coherence tomography (OCT) platform. The Phase II funding, supported by the US National Institutes of Health (NIH) and National Eye Institute (NEI), is intended to help the company deliver a system for point-of-care diagnosis of debilitating retinal diseases. Meanwhile, Wax and colleagues have just published results from the first clinical study using Lumedica equipment for retinal iamging, with results suggesting strong potential for ...

Fife, Scotland-based Optos specializes in ultra-widefield retinal imaging for ophthalmology applications, including optical coherence tomography (OCT) equipment. Winning a Queen’s Award for the third time, on this occasion for innovation, Optos has now sold more than 16,000 imaging systems worldwide. This year’s award was specifically for the company’s “California” retinal imager, which is used to help manage conditions including age-related macular degeneration (AMD) – the world’s leading cause of blindness. “Optos is the only company in the world that provides ultra-widefield imaging technology, which gives a 200° view of the retina in a single capture,” claims ...

iversified optoelectronics company Excelitas has signed a deal to acquire Axsun Technologies from its current owner Anzu Partners. According to the companies involved, the transaction is expected to close in early 2019. No details about the agreement have been disclosed, but Axsun’s CEO Jonathan Hartmann said: “This is an outstanding opportunity for Axsun, our customers, and our employees as we continue to expand our product line and develop new markets together with Excelitas.” Massachusetts-based Axsun, which is best known for its swept-source optical coherence tomography (OCT) laser engines, became part of Anzu just over three years ago , after its ...

A clinical study of malignant melanoma suggests that optical imaging of the most aggressive form of skin cancer could yield a faster assessment of particularly dangerous tumors. According to the UK-based optical coherence tomography (OCT) hardware developer Michelson Diagnostics , whose equipment was used in the study by four European dermatology research groups, the technique could offer a “short-cut” to identifying advanced cancers that have begun to spread. That might provide patients with a more aggressive or advanced tumor access to appropriate treatment more quickly, while those with less virulent melanomas could be spared invasive and expensive sentinel lymph-node biopsies that ...

Hamamatsu Photonics has developed a supercontinuum light source, also known the SC light source, that produces higher brightness – approximately 1000 times higher than the company’s own range of xenon lamps. At the same time, the SC source maintains the high stability equivalent to that of xenon lamps by optimizing output conditions and also using a high nonlinear optical fiber as its nonlinear optical material. This source is targeting the market for measuring the complex structure of semiconductor optical measurements. The company added that its official commercial release will be in the spring of 2019. The new SC light source ...

London-listed optics company Gooch & Housego (G&H) has completed another significant acquisition as part of its diversification strategy – this time with a deal to buy US-based Gould Fiber Optics (GFO). Worth up to $16.4 million, the agreement should enhance G&H’s position in the aerospace and defense sectors, particularly in regard to the important US market. Military focus Founded in 1978 and headquartered in Baltimore, GFO specializes in the design, development and manufacture of fiber-optic components and subsystems, and is said to provide key components to some top-ranking US aerospace and defense customers. “The GFO product range is ...

Photo-fragmentation Venture-backed French startup company Keranova says that its femtosecond laser system will “revolutionize” the field of cataract operations, by providing surgeons with a single tool that can be used for the entire procedure. The St. Etienne firm says that it has found a way to improve on the current generation of ultrafast laser equipment, which is unable to complete the crucial lens photo-fragmentation step quickly enough. Surgical disappointment Presenting the company’s technology during an industry session at this week’s SPIE Photonics Europe event in Strasbourg, Keranova’s scientific director Aurélien Bernard explained that despite the introduction ...

CareWear and Orbis take second and third in new-product pitch contest at SPIE Photonics West. Startup winners: 3,2,1: Orbis's Simpson; Clearview's Castel; and PhotoniCare's Shelton. PhotoniCare , a spinout of the University of Illinois at Urbana-Champaign (UIUC), which has developed a handheld, low-cost imaging platform for medical applications such as inspecting the eardrum, was named the winner of the 2018 SPIE Startup Challenge, last week during Photonics West in San Francisco. The ClearViewT, the first product on the Photonicare platform is described as “being able to fundamentally change the way physicians manage middle ear infections, one ...

A heart attack, or myocardial infarction (MI), can cause considerable damage to the tissues of the heart, and a better understanding of that damage would be a valuable step towards improved treatment and therapy after the attack. Researchers at the University of Houston have developed a technique based on optical coherence elastography (OCE) that could be used for biomechanical characterization of MI, and be a useful tool to study heart repair. The work was published in Biomedical Optics Express . "About one million people suffer heart attacks every year, and there is currently no cure for the resulting cardiac tissue scarring ...

Optical coherence tomography has become a standard technique in ophthalmology, thanks to its easy fit with clinical workflows and the ability to image particular zones of the eye, such as the anterior chamber and the cornea. Use of the same technique to image the whole eye has proved challenging. OCT's limited imaging depth can be improved though Fourier domain methods and use of modern swept-source laser sources, but the optics of the eye prevent the focusing of light on both the anterior chamber and the retina simultaneously without sacrificing resolution. A project from Poland's Nicolaus Copernicus University and ...

Germany’s Federal Ministry of Education and Research (BMBF) has backed a project to explore the potential of optical coherence tomography (OCT) to improve remote laser welding in car production. Funded under the country’s “Photonics Research Germany” program, the effort includes representatives from auto giant BMW, who will work alongside laser welding and OCT experts at Precitec, Blackbird Robotersysteme, Emil Bucher, and the Technical University of Munich. The project utilizes a Blackbird scanner comprising an “intelliWELD” PR scan head provided by Scanlab , a control unit, and an integrated OCT scanner. The team adds that imaging relies on ultra-fast workpiece ...

LioniX International (LXI) and Academic Medical Center (AMC) of the University of Amsterdam are collaborating on the development of Photonic Integrated Circuit-based Optical Coherence Tomography modules. The partners say that the implementation of PIC-based technologies in OCT modules will enable miniaturized handheld OCT modules and so broaden the scope and application of OCT-based systems. AMC and LXI have signed a collaboration agreement to accelerate the development of PIC-based OCT modules with a clear link to the clinical testing, which they say is essential for successful market introduction for these modules. Furthermore, both parties are participating in an EU funded Eurostars ...

Sales into G&H’s other target market sector – life sciences – have risen at a slower rate, but at £9.6 million were still up nearly 10 per cent on the prior year. Key applications here include optical coherence tomography (OCT), laser surgery and microscopy, with Webster writing: “Despite the increase in revenue the [life sciences] profit did decline year on year, which is primarily due to the investments made into future capabilities. Though life sciences is a relatively small sector for G&H, we see this as a strategically important one going forward.

New instrument from Horizon 2020 project will use OCT and MPT for high-resolution imaging. Piccolo project: the European consortium A project funded under the EU Horizon 2020 program aims to develop a novel endoscope for the identification and diagnosis of colorectal cancer, the latest step in the use of optical technologies to tackle one of the world's predominant cancers. Running for three years until December 2019, and involving nine European industrial and research partners led by Spain's Tecnalia Research & Innovation research center, the Piccolo project envisages an advanced endoscope instrument able to deliver high-resolution structural and functional imaging ...

The Institute of Biological and Medical Imaging at Helmholtz Zentrum München , Germany, is heading a research project entitled ”Hybrid optical and optoacoustic endoscope for esophageal tracking” or ESOTRAC . This four-year, €4 million, pan-European project will bring together engineers and physicians to develop a novel hybrid endoscopic instrument for early diagnosis and staging of esophageal cancer. The finished device is expected to reduce the number of unnecessary biopsies and, importantly, facilitate early-disease detection leading to earlier start of therapy, which will improve therapeutic efficacy over late-disease treatment and, ultimately, cost-savings for health care systems. ESOTRAC was awarded the €4 million ...

The BiOS Expo, part of SPIE's Photonics West event taking place this week in San Francisco, witnessed the unveiling of a new low-cost optical coherence tomography (OCT) scanner that developer Lumedica believes could dramatically extend the impact of the imaging technology for eye health. Founded in Durham, North Carolina, by an experienced team of engineers including chief scientist Adam Wax from Duke University, Lumedica’s debut scanner is priced at $10,000 – in a sector where entry-level equipment typically costs at least $35,000. Bottom-up design Wax explains that the low cost is achieved by using optical components already ...

Employer Description BEST in OPHTHALMOLOGY in the USA U.S. News & World Report has once again ranked Bascom Palmer as the Best in Ophthalmology for 2015-2016 . This is the 12th consecutive year we have received the #1 ranking in the annual Best Hospitals survey. Bascom Palmer has received the #1 ranking a remarkable fourteen times (1994, 1998, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, and 2016). Bascom Palmer’s Research Mission The future of ophthalmology lies in the creation of new knowledge and technology and its rapid translation into the clinic to help patients. Our ...