1. Articles from jstage.jst.go.jp

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    1. Stabilization of High Risk Coronary Plaque on Optical Coherence Tomography and Near-Infrared Spectroscopy by Intensive Lipid-Lowering Therapy With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor

      Stabilization of High Risk Coronary Plaque on Optical Coherence Tomography and Near-Infrared Spectroscopy by Intensive Lipid-Lowering Therapy With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor

      A 70-year-old woman with hypertension and dyslipidemia underwent drug-eluting stent implantation in the mid-left anterior descending artery (LAD) due to acute coronary syndrome (ACS). Optical coherence tomography (OCT) during the index procedure showed lipid-rich plaque in non-culprit lesions of the proximal LAD and mid-right coronary artery (Figure B,E). Near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) showed plaque with high lipid burden in both sites (Figure C,F). Intensive lipid-lowering therapy with combined strong statin and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor was started after the index procedure. Scheduled 10-month follow-up OCT and NIRS-IVUS showed increase in minimum fibrous cap thickness ...

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    2. Detection of enamel subsurface lesions by swept-source optical coherence tomography

      Detection of enamel subsurface lesions by swept-source optical coherence tomography

      This study aimed to non-destructively analyze the progression of subsurface enamel caries using swept-source optical coherence tomography (SS-OCT), a recently developed imaging analysis modality. Artificial enamel caries at various stages of demineralization were created in bovine tooth enamel using a modified lactic acid gel system. Untreated enamel served as a control. OCT images from cross-sections of enamel were collected. Mineral density, distribution, and histological changes were analyzed using an electron probe microanalyzer, scanning electron microscopy, and contact microradiography. The Raman spectrum and X-ray structural analysis of the enamel surfaces were determined. SS-OCT detected significant differences in mineral loss among the ...

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    3. Optical Coherence Tomography/Optical Frequency Domain Imaging: Imaging Application for Assessment of Human Carotid Plaque

      Optical Coherence Tomography/Optical Frequency Domain Imaging: Imaging Application for Assessment of Human Carotid Plaque

      Optical coherence tomography (OCT) is an intravascular imaging tool. Its high resolution facilitates detailed examination of intravascular morphological characteristics. In the coronary field, OCT systems are applied as practical clinical diagnostic method. In the carotid artery field, OCT is not covered by health insurance, and it is used as a research tool. We have published many reports on the morphological characteristics of carotid artery lesions on OCT or its application for carotid artery stenting. In this article, we review the application of OCT for carotid artery plaque and its usefulness.

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    4. Different Neoatherosclerosis Patterns in Drug-Eluting- and Bare-Metal Stent Restenosis ― Optical Coherence Tomography Study ―

      Different Neoatherosclerosis Patterns in Drug-Eluting- and Bare-Metal Stent Restenosis ― Optical Coherence Tomography Study ―

      Abstract Background: There are few reports about the differences between drug-eluting stents (DES) and bare metal stents (BMS) in neoatherosclerosis associated with in-stent restenosis (ISR), so we compared the frequency and characteristics of neoatherosclerosis with ISR evaluated by optical coherence tomography (OCT) in the present study. Methods and Results: Between March 2009 and November 2016, 98 consecutive patients with ISR who underwent diagnostic OCT were enrolled: 34 patients had a BMS, 34 had a 1st-generation DES, and 30 had a 2nd-generation DES. Neoatherosclerosis was defined as a lipid neointima (including a thin-cap fibroatheroma [TCFA] neointima, defined as a fibroatheroma with ...

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      Mentions: Osaka University
    5. High-accuracy endoscopic microscopy using a thin, 1.5 mm diameter probe with optical coherence tomography

      High-accuracy endoscopic microscopy using a thin, 1.5 mm diameter probe with optical coherence tomography

      We developed an endoscopic microscopy system with 20 nm accuracy that affords inspection through narrow gaps using a thin, 1.5 mm diameter probe. Accuracy was improved using Optical Coherence Tomography (OCT). The frequency modulated light source is stabilized with closed control from self-interference measurement. The probe is driven by two miniature motors, which allow three-dimensional scanning of an internal surface. Imaging performance is 60 frames per second. The high accuracy with narrow clearance capabilities of this system reduces the need for machine overhauls, which affords trustworthy daily inspections and hence greater machine reliability.

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    6. Effect of a coating material containing surface reaction-type pre-reacted glass-ionomer filler on prevention of primary enamel demineralization detected by optical coherence tomography

      Effect of a coating material containing surface reaction-type pre-reacted glass-ionomer filler on prevention of primary enamel demineralization detected by optical coherence tomography

      We used optical coherence tomography to examine the effect of a coating material containing surface reaction-type pre-reacted glass-ionomer (S-PRG) filler on primary enamel demineralization in 18 extracted human primary teeth. The pulp was removed, and each tooth was ultrasonically cleaned with distilled water. Six teeth were treated with 0.1-M lactic acid buffer solution (De group). In the second group (n = 6), a thin film of coating material was applied before demineralization (PRG group). A third group (Control group; n = 6) was maintained in artificial saliva. Using optical coherence tomography, we measured peak signal intensity (dB) and width at 1 ...

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    7. Assessment of root caries under wet and dry conditions using swept-source optical coherence tomography (SS-OCT)

      Assessment of root caries under wet and dry conditions using swept-source optical coherence tomography (SS-OCT)

      The purpose of this study was to compare optical properties of root caries under two observing conditions using swept-source optical coherence tomography (SS-OCT). In vitro and natural root caries were observed by SS-OCT under wet and dry conditions, followed by confocal laser scanning microscope (CLSM) and transverse microradiography (TMR). Signal intensity (SI), distance between SI peaks (SI-distance) and optical lesion depth were obtained from OCT. Lesion depth was measured from CLSM; lesion depth (LD TMR ) and mineral loss (ML) were obtained from TMR. In vitro root caries under wet and dry conditions showed different OCT images and SI patterns. Lesion ...

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    8. In vitro and clinical evaluation of optical coherence tomography for the detection of subgingival calculus and root cementum

      In vitro and clinical evaluation of optical coherence tomography for the detection of subgingival calculus and root cementum

      This study evaluated the effectiveness of swept-source optical coherence tomography (ss-OCT) for detecting calculus and root cementum during periodontal therapy. Optical coherence tomography (OCT) images were taken before and after removal of subgingival calculus from extracted teeth and compared with non-decalcified histological sections. Porcine gingival sheets of various thicknesses were applied to the root surfaces of extracted teeth with calculus and OCT images were taken. OCT images were also taken before and after scaling and root planing (SRP) in human patients. In vitro , calculus was clearly detected as a white-gray amorphous structure on the root surface, which disappeared after removal ...

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    9. Visualization of viscoelastic behavior in vivo skin using optical coherence tomography-based straingraphy combined with suction device

      Visualization of viscoelastic behavior in vivo skin using optical coherence tomography-based straingraphy combined with suction device

      Although various apparatuses have been developed to assess the skin mechanical function, the spatial viscoelastic behavior of each skin layer including the epidermis and dermis is yet unclear. To resolve that lack of clarity, we built a handmade system combining a suction device with optical coherence tomography (OCT). OCT can visualize the vertical section of the skin with high spatial resolution and high acquisition speed. In addition, we developed an algorithm for time-dependent strain tomography, named Dynamic Optical Coherence Straingraphy (D-OCSA), which can analyze the changes in strain distributions over time in sequential OCT images. Using the system, successive OCT ...

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    10. The Diagnosis of Spontaneous Coronary Artery Dissection by Optical Coherence Tomography

      The Diagnosis of Spontaneous Coronary Artery Dissection by Optical Coherence Tomography

      Spontaneous coronary artery dissection (SCAD) is rare, but it frequently presents as acute myocardial infarction. It is frequently fatal and most cases are diagnosed at autopsy. We herein present the case of a 65-year-old woman with ST-elevation and myocardial infarction due to SCAD. Optical coherence tomography (OCT) helped us to confirm the diagnosis. The information on the intravascular morphology provided by OCT imaging is much more detailed in comparison to that provided by coronary angiography (CAG) and intravascular ultrasound (IVUS).

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    11. Optical Coherence Tomography Assessment of Glucose Fluctuation Impact on the Neointimal Proliferation After Stent Implantation in a Diabetic/Hypercholesterolemic Swine Model

      Optical Coherence Tomography Assessment of Glucose Fluctuation Impact on the Neointimal Proliferation After Stent Implantation in a Diabetic/Hypercholesterolemic Swine Model

      The aim of the present study was to investigate the effects of glucose fluctuation on neointimal proliferation after stent implantation by optical coherence tomography (OCT) in a diabetic/hypercholesterolemic (DM/HC) swine model. A total of 24 everolimus-eluting stents (EES) were implanted in the right coronary artery (RCA) of the animals using a 20% overstretch ratio. The 24 swines were divided into a DM-high glucose fluctuation (HGF) group (n = 8), DMlow glucose fluctuation (LGF) group (n = 8), and a control group (n = 8). Percent diameter stenosis (%DS), late loss (LL), percent area stenosis (%AS), and neointimal thickness (NIT) were analyzed ...

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    12. Intravascular Images of Coronary Stenosis with Multiple Channels in a Patient with Antiphospholipid Syndrome: The Optical Coherence Tomography Findings

      Intravascular Images of Coronary Stenosis with Multiple Channels in a Patient with Antiphospholipid Syndrome: The Optical Coherence Tomography Findings

      Intravascular images of coronary stenosis by antiphospholipid syndrome (APS) would be beneficial to understand the mechanism of this disease. A 59-year-old woman with APS/systemic lupus erythematosis (SLE) underwent emergent coronary angiography which revealed stenosis with micro channels in the proximal left anterior descending artery. According to optical coherence tomography (OCT), the central lumen was surrounded by a thick septum with a homogenous and high intensity. Multiple small channels existed near the vessel wall with diffuse intimal hyperplasia. White thrombi were floating distal to the stenosis. Intravascular images obtained by optical coherence tomography (OCT) revealed the microstructure of complex coronary ...

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    13. Comparison between Preoperative Optical Coherence Tomography Findings of Carotid Artery Stenosis and Pathological Specimen of Removed Carotid Plaque: Case Report

      Comparison between Preoperative Optical Coherence Tomography Findings of Carotid Artery Stenosis and Pathological Specimen of Removed Carotid Plaque: Case Report

      Objective: Optical coherence tomography (OCT) has recently been applied for the characterization of carotid plaques, but few studies have compared OCT findings with findings from histopathologic examination of carotid plaques. We consider the accuracy, problems, and limitation of OCT findings by comparing OCT findings of carotid artery stenosis and pathological specimen of removed carotid plaque, and confirm that the interpretation of coronary artery findings of OCT can be applied to OCT findings of carotid artery plaque. Case Presentation: A 63-year-old man with asymptomatic left carotid stenosis underwent carotid endarterectomy (CEA). Findings for histopathologic assessment of excised plaque were compared with ...

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    14. Serial Observations of In-Stent Restenosis Treated With Drug-Coated Balloon Angioplasty by Optical Coherence Tomography and Coronary Angioscopy - A Case Series

      Serial Observations of In-Stent Restenosis Treated With Drug-Coated Balloon Angioplasty by Optical Coherence Tomography and Coronary Angioscopy - A Case Series

      The drug-coated balloon (DCB) is a device that is used to reduce the risk of stent re-implantation in patients with in-stent restenosis (ISR). However, imaging findings of the drug covering the neointimal plaque immediately after treatment of ISR by DCB, and during follow-up, have only been discussed in a few reports. Herein, we describe the use of optical coherence tomography (OCT) and angioscopy to evaluate ISR before and after treatment with DCB, and during the follow-up period in 3 patients. The patients developed critical ISR during the follow-up period after drug-eluting stent (DES) implantation. The patients included a 70-year-old woman ...

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    15. Neoatherosclerosis in the Iliac Artery Stent ― Insights From Optical Coherence Tomography and Intravascular Ultrasound ―

      Neoatherosclerosis in the Iliac Artery Stent ― Insights From Optical Coherence Tomography and Intravascular Ultrasound ―

      There has been increasing attention on neoatherosclerosis in coronary arteries following implantation of bare-metal and drug-eluting stents.1,2 Neoatherosclerosis might be a concern even in the field of peripheral artery disease (PAD). A 75-year-old man with hypertension, diabetes mellitus, dyslipidemia and a history of right iliac artery stenting with a Wallstent 12 years previously, was referred to hospital for treatment of recurrent/progressive intermittent claudication (Rutherford category 3) that had started 6 months earlier. Ankle brachial index (ABI) was 0.51 on the right. Diagnostic angiography showed significant in-stent restenosis in the right iliac artery stent (Figure A). Intravascular ...

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    16. Application to skin physiology using optical coherence tomography

      Application to skin physiology using optical coherence tomography

      Background and aims: The sweat glands and peripheral vessels beneath the skin surface act as minute organs governed by the skin sympathetic nerves and have important physiological functions for body temperature control and nutrition support along with maintenance of a peripheral organization. Dynamics of the mental sweating of sweat glands and the peripheral vessels reflect the activity of a sympathetic nerve. The purpose of this paper is to study the dynamic observation and analysis of sweat glands and a peripheral vessels by optical coherence tomography (OCT). Materials and Methods: In the dynamic analysis of mental sweating of sweat glands, after ...

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      Mentions: Osaka University
    17. Optical Coherence Tomography for Online Guidance of Complex Coronary Interventions

      Optical Coherence Tomography for Online Guidance of Complex Coronary Interventions

      Decision making on lesion preparation and stent/scaffold optimization are cornerstones of patient outcome. Intravascular imaging recently emerged as a critical modality to achieve better results of stent/scaffold implantation and superior clinical outcomes compared with coronary angiography alone. Optical coherence tomography (OCT), a light-based intravascular imaging modality with high frame rate in acquisition and very high speed pullback, can interrogate the target vessel in a couple of seconds, and immediately display a pristine longitudinal lumen contour with automatic detection of lesion severity, site and lumen/stent areas. Further, OCT provides pivotal information on sites of calcium, with accurate measurements ...

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    18. Optical Coherence Tomography of De Novo Lesions and In-Stent Restenosis in Coronary Saphenous Vein Grafts (OCTOPUS Study)

      Optical Coherence Tomography of De Novo Lesions and In-Stent Restenosis in Coronary Saphenous Vein Grafts (OCTOPUS Study)

      Background: The OCTOPUS registry prospectively evaluates the procedural and long-term outcomes of saphenous vein graft (SVG) PCI. The current study assessed the morphology of de novo lesions and in-stent restenosis (ISR) in patients undergoing PCI of SVG. Methods and Results: Optical coherence tomography (OCT) of SVG lesions in consecutive patients presenting with stable CAD and ACS was carried out. Thirty-nine patients (32 de novo and 10 ISR lesions) were included in the registry. ISR occurred in 5 BMS and 5 DES. There were no differences in the presence of plaque rupture and thrombus between de novo lesions and ISR. Lipid-rich ...

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    19. Assessment of occlusal fissure depth and sealant penetration using optical coherence tomography

      Assessment of occlusal fissure depth and sealant penetration using optical coherence tomography

      Swept source optical coherence tomography (SS-OCT) is an interferometric imaging technique. This study aimed to assess SS-OCT as a diagnostic tool for the evaluation of occlusal fissure depth and sealant penetration into fissure. Seventy investigation sites of occlusal fissures without visible evidence of caries were categorized into four groups (smooth, shallow, intermediate, and deep fissures). Categorization utilized two methods: 1) visually, using a computer screen, and 2) using SS-OCT images. After sealant placement, penetration was observed in SS-OCT. The results obtained from SS-OCT and visual inspections were compared with those of confocal laser scanning microscope (CLSM). The diagnostic power of ...

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    20. Relationship Between Thickness of Calcium on Optical Coherence Tomography and Crack Formation After Balloon Dilatation in Calcified Plaque Requiring Rotational Atherectomy

      Relationship Between Thickness of Calcium on Optical Coherence Tomography and Crack Formation After Balloon Dilatation in Calcified Plaque Requiring Rotational Atherectomy

      Background: Target lesion calcification is known to influence percutaneous coronary intervention. We evaluated the effects of rotational atherectomy (RA) and subsequent balloon angioplasty on calcified coronary lesions using optical coherence tomography (OCT). Methods and Results: Thirty-seven calcified lesions in 36 patients were treated with RA followed by balloon angioplasty and stent implantation. In all patients, serial OCT images obtained after RA, after balloon angioplasty, and after stent implantation were analyzed at 1-mm intervals. The arc and thickness of the calcium component were measured after RA. The formation of calcium cracks was assessed after balloon angioplasty. A total of 625 segments ...

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    1-24 of 106 1 2 3 4 5 »
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