1. Articles from Thieme

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    1. A System for Clinical Use of Endoscopic Optical Coherence Tomography

      A System for Clinical Use of Endoscopic Optical Coherence Tomography

      Introduction: Optical Coherence Tomography (OCT) allows non-invasive high-resolution imaging of tissues. With a penetration depth of a few millimeters it's possible to image the tympanic membrane and the close-by part of the tympanum, e.g. for diagnostics of otitis media and middle ear effusion. In the field of in vivo examination there are difficulties in access to the human tympanic membrane due to the narrow and curved external ear canal. We report a compact endoscopic OCT system for use in clinical research. Methods: We use a 3,5 mm endoscopic GRIN lens for video endoscopy and OCT. OCT is ...

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    2. The Use of Optical Coherence Tomography for the Detection of Early Diabetic Retinopathy

      The Use of Optical Coherence Tomography for the Detection of Early Diabetic Retinopathy

      Diabetic retinopathy (DR) is one of the leading causes of vision loss globally with a severe burden on all societies due to its high treatment and rehabilitation costs. The early diagnosis of DR may provide preventive steps (including retinal laser therapy and tight carbohydrate, blood pressure, and cholesterol control) that could in turn help to avoid progression of the pathology with the resultant vision loss. Optical coherence tomography (OCT) enables the in vivo structural imaging of the retina, providing both qualitative (structure) and quantitative (thickness) information. In the past decades, extensive OCT research has been done in the field of ...

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    3. Optical Coherence Tomography for the Management of Fibrous Dysplasia of the Skull Base with Optic Nerve Involvement

      Optical Coherence Tomography for the Management of Fibrous Dysplasia of the Skull Base with Optic Nerve Involvement

      Background The skull base is the most common site of the craniofacial skeleton to be affected by fibrous dysplasia (FD). A significant proportion of such FD patients present with compression of the optic nerve, which can cause visual impairment, but most patients initially do not experience vision loss. Controversy exists regarding whether to proceed with a prophylactic surgical decompression of the optic nerve or to elect for “watchful waiting.” Optical coherence tomography (OCT), a physiologic imaging modality widely used to assess the condition of the retinal nerve fiber layer (RNFL), has been useful in the monitoring of other compressive lesions ...

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    4. The Clinical Utility of Ocular Coherence Tomography in Evaluation and Management of Skull Base Disorders

      The Clinical Utility of Ocular Coherence Tomography in Evaluation and Management of Skull Base Disorders

      Ocular Coherence Tomography (OCT), aka Optical Coherence Tomography, is a non-invasive imaging test that uses light waves to capture micrometer-resolution, three-dimensional images from within the retina. OCT is based on low-coherence interferometry, typically employing near-infrared light. OCT provides near-microscopic resolution and has been employed as a clinical tool in the measurement of peripapillary retinal nerve fiber layer (RNFL) thickness and macular retinal ganglion cell (RGC) layer thickness. In our institution, in the management of thousands of patients, in conjunction with clinical neuro-ophthalmologic evaluation, we have found OCT provides additional useful information, leading to better management decisions, and useful diagnostic and ...

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    5. Volumetric laser endomicroscopy can target neoplasia not detected by conventional endoscopic measures in long segment Barrett’s esophagus

      Volumetric laser endomicroscopy can target neoplasia not detected by conventional endoscopic measures in long segment Barrett’s esophagus

      Methods and study aims: The incidence of esophageal cancer is rising despite increased surveillance efforts. Volumetric laser endomicroscopy (VLE) is a new endoscopic imaging tool that can allow for targeted biopsy of neoplasia in Barrett’s esophagus. We report a series of 6 patients with long-segment Barrett’s esophagus ( > 3 cm), who underwent a session of endoscopy with volumetric laser endomicroscopy, after a separate prior session of standard high-definition endoscopy with narrow band imaging (NBI) and random biopsies that did not reveal neoplasia. In all six patients, the first endoscopy was the index endoscopy diagnosing the Barrett’s esophagus. All ...

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    6. SLO Fundus Imaging Is the Most Sensitive Modality of Multimodal Imaging for Macular Microembolisms with Subtle Signs

      SLO Fundus Imaging Is the Most Sensitive Modality of Multimodal Imaging for Macular Microembolisms with Subtle Signs

      Background. Microemboli of fat or other material into the terminal macular retinal circulation can be difficult to diagnose. We report 2 cases that showed subtle signs where SLO fundus imaging was most sensitive to precisely outline the limits of the inner retina infarction. Patients and Methods. Multimodal imaging analysis was performed including fundus photography, fluorescein angiography, indocyanine green angiography, Optical Coherence Tomography and SLO fundus imaging of 2 cases with suspected infarction of the inner retina. Cases. A 30-year-old man reported a grey central spot OD a few days after being squeezed between two cars with a sacrum fracture. Vision ...

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    7. Spectral Domain Optical Coherence Tomography for the Characterization of Kyrieleis Exudates Involving Both the Fovea and Retinal Vessels

      Spectral Domain Optical Coherence Tomography for the Characterization of Kyrieleis Exudates Involving Both the Fovea and Retinal Vessels

      In 1933 and 1950, Kyrieleis first described the presence of segmental white lesions in the walls of retinal arterioles in a case of ocular tuberculosis [ 1 ], [ 2 ]. These lesions are rarely seen and their pathophysiology remains debated although a relationship with infectious and inflammatory conditions has been proposed [ 3 ]. We report a patient who presented these lesions not only around retinal vessels very much alike those described in the original article but also involving the macular area and retinal veins. Since the patient suffered from dense vitreous haze as a result of an ocular toxoplasmosis relapse, this finding was revealed ...

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    8. Optical Coherence Tomography in Multiple Sclerosis

      Optical Coherence Tomography in Multiple Sclerosis

      Retinal optical coherence tomography (OCT) has recently become a vital tool for clinicians and researchers in ophthalmology and, increasingly, in neurology. Optical coherence tomography is quickly and easily performed, well-tolerated by patients, and allows high-resolution viewing of unmyelinated axons and other retinal structures in vivo. These factors have led OCT to find favor as a method of quantifying neuroaxonal loss in multiple sclerosis (MS), and the increasing acceptance of the anterior visual pathway as a model to investigate MS in humans. In this short review, the authors discuss OCT findings in MS research, and the relationships of these structural findings ...

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    9. Optical coherence tomography after pediatric heart transplantation - the experience of 49 examinations

      Optical coherence tomography after pediatric heart transplantation - the experience of 49 examinations

      Objectives: Cardiac allograft vasculopathy (CAV) is the most important risk factor for long term graft survival after pediatric heart transplantation. 10 years after pediatric heart transplantation 35 percent suffer from CAV according to the International Society for Heart and Lung Transplantation (ISHLT). The graft survival is merely 50 percent five years after the first detection of cardiac allograft vasculopathy using conventional catheter techniques. Therefore, a method for early detection of CAV is mandatory in order to alter or at best stop the course of the disease. The optical coherence tomography (OCT) enables high-resolution intracoronary visualization of intimal hyperplasia, plaque formation ...

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    10. Optical Coherence Tomography for the Neurologist

      Optical Coherence Tomography for the Neurologist

      Optical coherence tomography (OCT) is a relatively new technology that is now routinely and very widely used by ophthalmologists for structural documentation of the optic nerve and retina. In neuro-ophthalmology and neurology, the value of OCT is ever expanding; its role in an increasing number of conditions is being reported in parallel with the advances of the technology. Currently, as a clinical tool, OCT is particularly useful for the structural measurement of peripapillary retinal nerve fiber layer thickness, optic nerve head volumetric analysis, and macular anatomy. Optic neuropathies of varied etiology (particularly from multiple sclerosis) may be the most common ...

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      Mentions: Laura J. Balcer
    11. Optical Coherence Tomography Opens a New Era in the Afferent Visual System Evaluation

      Optical Coherence Tomography Opens a New Era in the Afferent Visual System Evaluation

      For decades, thinning of the retinal nerve fiber layer in optic neuropathy could only be observed ophthalmoscopically or using red-free fundus photography. These days are over. Subsequently, different techniques to image the optic nerve and the retina have been developed. Optical coherence tomography (OCT) has gained the most attention and has opened a new area of revolutionary diagnostic possibilities. OCT is a noncontact diagnostic imaging technique that provides detailed, cross-sectional images of the retina and the optic disc in vivo. It was first used in 1991 to visualize the eye.[ 1 ] Image capture is noninvasive, painless, and fast. The technology ...

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    12. Applications of Optical Coherence Tomography in Pediatric Clinical Neuroscience

      Applications of Optical Coherence Tomography in Pediatric Clinical Neuroscience

      For nearly two centuries, the ophthalmoscope has permitted examination of the retina and optic nerve—the only axons directly visualized by the physician. The retinal ganglion cells project their axons, which travel along the innermost retina to form the optic nerve, marking the beginning of the anterior visual pathway. Both the structure and function of the visual pathway are essential components of the neurologic examination as it can be involved in numerous acquired, congenital and genetic central nervous system conditions. The development of optical coherence tomography now permits the pediatric neuroscientist to visualize and quantify the optic nerve and retinal ...

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    13. Optical Coherence Tomography (OCT) – A New Diagnostic Tool in Psychiatry?

      Optical Coherence Tomography (OCT) – A New Diagnostic Tool in Psychiatry?

      Optical coherence tomography (OCT) is a non-invasive, contact-less imaging method which provides an “in vivo” representation of the retina. It allows the quantitative measurement of retinal nerve fibre layer thickness (RNFLT) and macula thickness (MT) and, in addition, is suitable to measure volumes (e. g., macula volume/MV). In the research of neurodegenerative diseases, OCT has been increasingly used and has shown its potential as a possible diagnostic tool over the course of the last few years. In recent years, the hypothesis that mental disorders like schizophrenia or unipolar depressive disorder have a degenerative component was established through a variety ...

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    14. Posterior Pole Asymmetry Analysis with Optical Coherence Tomography

      Posterior Pole Asymmetry Analysis with Optical Coherence Tomography

      Background: The aim of this study was to evaluate the reproducibility of the posterior pole asymmetry analysis (PPAA) in glaucomatous eyes and healthy controls in comparison to retinal nerve fiber layer measurements (RNFL) with spectral domain optical coherence tomography (SD-OCT). Patients and Methods: Prospectively, in a single session by one operator, three measurements were taken of the retinal thickness with the PPAA and three measurements of the RNFL with the eye-tracker function of the Heidelberg Spectralis SD-OCT. Results: The mean intraclass correlation coefficient (ICC) and lower confidence intervals (in parentheses) for PPAA were 0.98 (0.96) in both healthy ...

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    15. A prospective study on 71 children to investigate normative pediatric values in optical coherence tomograph

      A prospective study on 71 children to investigate normative pediatric values in optical coherence tomograph

      Aims: Optical coherence tomography (OCT) is a noninvasive radiation-free method for imaging retinal structures and measuring retinal nerve fiber layer (RNFL) thickness and total macular volume (TMV). Newer devices even allow segmentation of all retinal layers and individualized follow-up comparisons. So far, normative values for this potential diagnostic tool in pediatric populations are widely lacking. The aim of this study is to investigate normal values in a healthy pediatric population for peripapillary RNFL, TMV, and layer segmentation in OCT. Methods: The study was approved by the responsible ethics committee and informed consent was obtained from all parents before any study ...

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    16. Case Report on OCT Findings in a Patient with Hereditary Optic Neuropathy and a Patient with Autosomal Dominant Optic Atrophy

      Case Report on OCT Findings in a Patient with Hereditary Optic Neuropathy and a Patient with Autosomal Dominant Optic Atrophy
      (Article in German) Background: Hereditary optic neuropathies lead to a decrease in visual acuity corresponding to a reduction of the ganglion cell layer and the nerve fibre layer. The most common neuropathies, Leber hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (ADOA), are mitochondrial disorders. Case Report: We describe two cases, one with LHON and one with ADOA, and demonstrate the decrease in thickness of the ganglion cell layer using spectral domain OCT (optical coherence tomography). Results: In the case with LHON, the ganglion cell layer and the nerve fibre layer showed a considerable reduction from the initial occurrence ...
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    17. Morphologic Classification of Reinke's Edema through Optical Coherence Tomography

      OBJECTIVE: Several classification systems for Reinke's edema have been proposed in the past, which are somewhat less than morphologically ideal. The objective of the present study is to evaluate the ability of optical coherence tomography (OCT) to attain a reproducible graduation of Reinke's edema. MATERIAL AND METHODS: In a prospective study, 30 consecutive patients underwent endolaryngeal, microsurgical resection of their Reinke's edema. Graduation was performed through OCT based on morphologic criteria, where each result was compared with that of other classification systems. RESULTS: In Reinke's edema grade I according to Glanz, a feathered pattern is found ...
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    18. Three-dimensional optical coherence tomography of Barrett’s esophagus and buried glands beneath neosquamous epithelium following radiofrequency ablation

      report three-dimensional (3D) endoscopic microscopy findings in Barrett's esophagus, using an endoscopic optical coherence tomography (OCT) system in one patient before and in one patient after radiofrequency ablation (RFA). Findings were compared with those in a normal patient without Barrett's esophagus. In the normal patient,findings were of regular flat squamous mucosa with small subepithelial vessels and glands. In the Barrett's esophagus patient, findings were of large, densely packed glands with distortion of mucosal architecture. In the post-RFA case, findings were of a small number of isolated glands buried beneath 300-500 microm of neosquamous epithelium and lamina ...
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    19. Intraductal optical coherence tomography during endoscopic retrograde cholangiopancreatography for investigation of biliary strictures

      Background and study aims: Optical coherence tomography (OCT) uses infrared light reflectance to produce high-resolution cross-sectional tissue images. The aim of this study was to demonstrate the feasibility of biliary intraductal OCT during endoscopic retrograde cholangiopancreatography (ERCP) and to assess the potential of the method to detect malignant biliary strictures. Patients and methods: Thirty-seven patients with biliary strictures were studied during therapeutic ERCP. Malignant strictures were defined as those that demonstrated malignant cells in brushing and/or biopsy specimens, and/or endoscopic ultrasound-guided fine-needle aspiration and/or surgery. Strictures that did not have malignant cells in resected specimens and were ...
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      Mentions: Pentax
    20. Changes of the Anterior Eye Segment after Eye Muscle Surgery - Evaluation by Optical Coherence Tomography in Children

      Background: The aim of this study was to quantify and to evaluate changes concerning anterior chamber depth, central corneal thickness and chamber angle width because of altered forces on the eye bulb after eye muscle surgery in children by means of optical coherence tomography. Patients and Methods: Over the course of four months, we measured central corneal thickness (CCT), anterior chamber depth (ACD) and chamber angle width at 0° (CW0) and 180° (CW180) in 28 eyes of 28 children, who underwent eye muscle surgery on one horizontal muscle. Measurements were taken preoperatively, one week and four months postoperatively using VisanteTM ...
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    21. Preoperative Assessment of Topographic Features in Macular Pucker using High-Definition Optical Coherence Tomography

      Background: To date, the surgical plan for the removal of epiretinal membranes is mainly adapted to the intraoperative situation. In the current study, we sought to investigate whether the surgical removal of macular pucker can be facilitated by the preoperative assessment of topographic features using high-definition optical coherence tomography (HD-OCT). Patients and Methods: In a consecutive case series, 20 eyes of 20 patients with macular pucker underwent full ophthalmological evaluation including high-definition optical coherence tomography (Cirrus, Carl Zeiss Meditec) prior to a three-port-pars plana vitrectomy with peel of the epiretinal membrane (ERM). Furthermore, we documented the intraoperative course. Results: Thirteen ...
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    22. Comparison of Different Optical Techniques for Determination of the Dimensions of Anterior Ocular Segment

      Background: The evaluation of the anterior ocular chamber sections along the optical axis/axis of vision has been carried out using single-line partial coherence interferometry for many years. Now, new technologies such as the Scheimpflug-technique of the Pentacam® (Oculus Optikgeräte GmbH, Wetzlar) and the optical coherence tomography of the VisanteTMOCT (Carl Zeiss Meditec AG, Jena) allow the two-dimensional imaging of the anterior ocular segment in addition to goniometry and ultrasonic biomicroscopy. Patients/Materials and Methods: The internal anterior chamber depth, central corneal thickness, angle-to-angle distance, and nasal and temporal anterior chamber angles of eight eyes (four patients) were examined using ...
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    23. Analysis of Murine Vascular Function In Vivo by Optical Coherence Tomography in Response to High-fat Diet

      In this study, we demonstrate the application of optical coherence tomography (OCT) as a contactless imaging technique to analyze vasodynamics in small blood vessels in vivo. The transluminal OCT imaging of vessels avoids micro traumata in the endothelium and circumvents surgical intervention. It can be performed in the intact perfused vessel and provides a new method to measure vascular function and dynamics in vivo. The resolution of 10 μm and the velocity of image acquisition are adequate to detect differences in the inner diameter, the maximal velocity, or the time to half-maximal diameter change of small vessels. We applied this ...
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    24. Optical Coherence Tomography (OCT) to Evaluate Cartilage Tissue Engineering

      Optical Coherence Tomography (OCT) to Evaluate Cartilage Tissue Engineering
      Aim: The aim of this study was to investigate hyaline cartilage defects treated with cell-seeded artificial matrix systems (two different collagen type I gels) with the method of optical coherence tomography (OCT) and to correlate the results with conventional histological and immunocytochemical staining. Method: Osteochondral blocks were harvested from 20 patients undergoing total knee replacement and trimmed to 2 × 2 cm. Under sterile conditions, chondral defects of 8 mm diameter were either filled with a collagen type I gel plug seeded with autologous chondrocytes (2 × 105/mL gel), or with a corresponding gel plug which was stabilised by a 20-fold ...
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    1-26 of 26
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