1. Articles from BMJ Open

    bmjopen.bmj.com

  2. 1-13 of 13
    1. Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study

      Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study

      Objectives: Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) is a novel OCT technology that was specifically designed for home monitoring of neovascular age-related macular degeneration (AMD). First clinical findings have been reported before. This trial investigates an improved prototype for patients with AMD and focusses on device operability and diagnostic accuracy compared with established spectral-domain OCT (SD-OCT). Design: Prospective single-arm diagnostic accuracy study. Setting: Tertiary care centre (University Eye Clinic). Participants: 46 patients with age-related macular degeneration. Interventions: Patients received short training in device handling and then performed multiple self-scans with the SELFF-OCT according to a predefined protocol. Additionally, all ...

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    2. Recognition of intracranial hypertension using handheld optical coherence tomography in children (RIO Study): a diagnostic accuracy study protocol

      Recognition of intracranial hypertension using handheld optical coherence tomography in children (RIO Study): a diagnostic accuracy study protocol

      Introduction: Paediatric intracranial hypertension (IH) is a rare but serious condition that can pose deleterious effects on the brain and vision. Estimating intracranial pressure (ICP) in children is difficult. Gold standard direct ICP measurement is invasive and carries risk. It is impractical to routinely perform direct ICP measurements over time for all children at risk of IH. This study proposes to assess the diagnostic accuracy of handheld optical coherence tomography (OCT), a non-invasive ocular imaging method, to detect IH in children. Methods and analysis: This is a prospective study evaluating the diagnostic accuracy of handheld OCT for IH in at ...

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    3. Detection of intracranial hypertension in children using optical coherence tomography: a systematic review

      Detection of intracranial hypertension in children using optical coherence tomography: a systematic review

      Objectives To evaluate the diagnostic capability of optical coherence tomography (OCT) in children aged under 18 years old with intracranial hypertension (IH). Design Systematic review. Methods We conducted a systematic review using the following platforms to search the keywords ‘optical coherence tomography’ and ‘intracranial hypertension’ from inception to 2 April 2020: Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, PubMed and Web of Science, without language restrictions. Our search returned 2729 records, screened by two independent screeners. Studies were graded according to the Oxford Centre for Evidence-Based Medicine and National Institutes of Health Quality Assessment Tool for observational studies. Results ...

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    4. Identification of anatomic risk factors for acute coronary events by optical coherence tomography in patients with myocardial infarction and residual nonflow limiting lesions: rationale and design of the PECTUS-obs study

      Identification of anatomic risk factors for acute coronary events by optical coherence tomography in patients with myocardial infarction and residual nonflow limiting lesions: rationale and design of the PECTUS-obs study

      Introduction: In patients with myocardial infarction, the decision to treat a nonculprit lesion is generally based on its physiological significance. However, deferral of revascularisation based on nonischaemic fractional flow reserve (FFR) values in these patients results in less favourable outcomes compared with patients with stable coronary artery disease, potentially caused by vulnerable nonculprit lesions. Intravascular optical coherence tomography (OCT) imaging allows for in vivo morphological assessment of plaque 'vulnerability' and might aid in the detection of FFR-negative lesions at high risk for recurrent events. Methods and analysis: The PECTUS-obs study is an international multicentre prospective observational study that aims to ...

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    5. Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders

      Cohort profile: a collaborative multicentre study of retinal optical coherence tomography in 539 patients with neuromyelitis optica spectrum disorders

      Purpose Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform. This repository should prove invaluable for studies using OCT to investigate NMOSD. Participants The current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected ...

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    6. Detection of intracranial hypertension in children using optical coherence tomography: a systematic review protocol

      Detection of intracranial hypertension in children using optical coherence tomography: a systematic review protocol

      Introduction Intracranial hypertension (ICH) in children can have deleterious effects on the brain and vision. It is notoriously difficult to estimate intracranial pressure (ICP) in children and existing methods deliver suboptimal diagnostic accuracy to be used as screening tools. Optical coherence tomography (OCT) may represent a valuable, non-invasive surrogate measure of ICP, as has been demonstrated in a number of associated conditions affecting adults. More recently, OCT has been employed within the paediatric age group. However, the role of OCT in detecting ICH in children has not been rigorously assessed in a systematic review for all relevant conditions. Here, we ...

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    7. Optical coherence tomography (OCT) in unconscious and systemically unwell patients using a mobile OCT device: a pilot study

      Optical coherence tomography (OCT) in unconscious and systemically unwell patients using a mobile OCT device: a pilot study

      Objective This study aims to evaluate the feasibility of retinal imaging in critical care using a novel mobile optical coherence tomography (OCT) device. The Heidelberg SPECTRALIS FLEX module (Heidelberg Engineering, Heidelberg, Germany) is an OCT unit with a boom arm, enabling ocular OCT assessment in less mobile patients. Design We undertook an evaluation of the feasibility of using the SPECTRALIS FLEX for undertaking ocular OCT images in unconscious and critically ill patients. Setting This study was conducted in the critical care unit of a large tertiary referral unit in the United Kingdom. Participants 13 systemically unwell patients admitted to the ...

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    8. Keratoconus detection using deep learning of colour-coded maps with anterior segment optical coherence tomography: a diagnostic accuracy study

      Keratoconus detection using deep learning of colour-coded maps with anterior segment optical coherence tomography: a diagnostic accuracy study

      Objective To evaluate the diagnostic accuracy of keratoconus using deep learning of the colour-coded maps measured with the swept-source anterior segment optical coherence tomography (AS-OCT). Design A diagnostic accuracy study. Setting A single-centre study. Participants A total of 304 keratoconic eyes (grade 1 (108 eyes), 2 (75 eyes), 3 (42 eyes) and 4 (79 eyes)) according to the Amsler-Krumeich classification, and 239 age-matched healthy eyes. Main outcome measures The diagnostic accuracy of keratoconus using deep learning of six colour-coded maps (anterior elevation, anterior curvature, posterior elevation, posterior curvature, total refractive power and pachymetry map). Results Deep learning of the arithmetical ...

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    9. Qualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Study

      Qualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Study

      Background/aims To develop a standardised grading scheme, using standard photos, for spectral-domain ocular coherence tomography (SD-OCT) images of the posterior eye and evaluate the interobserver agreement among trained ophthalmologists in identifying pathological changes. Methods Subjects were recruited from Liwan District, Guangzhou, with SD-OCT data collection from June 2013 to November 2013 as part of 10-year follow-up visits from the Liwan Eye Study. All subjects underwent SD-OCT imaging of the macula with scanning lines analysed by two ophthalmologists to assess for the presence of 12 different posterior segment lesions. Per cent agreement for each lesion between the graders and quantitative ...

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    10. Vascular flow density in pathological myopia: an optical coherence tomography angiography study

      Vascular flow density in pathological myopia: an optical coherence tomography angiography study

      Objectives To investigate vascular flow density in pathological myopia with optical coherence tomography (OCT) angiography. Design A prospective comparative study was conducted from December 2015 to March 2016. Setting Participants were recruited in Beijing Tongren Hospital. Participants A total of 131 eyes were enrolled, which were divided into three groups: 45 eyes with emmetropia (EM; mean spherical equivalent (MSE) 0.50D to −0.50D), 41 eyes with high myopia (HM; MSE ≤−6.00D, without pathological changes), and 45 eyes with pathological myopia (PM; MSE ≤−6.00D and axial length (AL) ≥26.5 mm, and with pathological changes). Main outcome measures ...

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    11. Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study

      Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study

      Introduction The mainstay treatment for reducing the symptoms of angina and long-term risk of heart attacks in patients with heart disease is stent implantation in the diseased coronary artery. While this procedure has revolutionised treatment, the incidence of secondary events remains a concern. These repeat events are thought to be due, in part, to continued enhanced platelet reactivity, endothelial dysfunction and ultimately restenosis of the stented artery. In this study, we will investigate whether a once a day inorganic nitrate administration might favourably modulate platelet reactivity and endothelial function leading to a decrease in restenosis. Methods and design NITRATE-OCT is ...

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    12. Is the peripapillary retinal perfusion related to myopia in healthy eyes? A prospective comparative study [RESEARCH]

      Is the peripapillary retinal perfusion related to myopia in healthy eyes? A prospective comparative study [RESEARCH]

      Myopia Strengths and limitations of this study The present study first explored the peripapillary and parafoveal perfusion of young, healthy myopic subjects with spectral domain optical coherence tomography (OCT) angiography. The novel technology of OCT angiography makes it possible to visualise the ocular circulation even to the capillary level.

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    13. Cross-sectional study: Does combining optical coherence tomography measurements using the ‘Random Forest’ decision tree classifier improve the prediction of the presence of perimetric deterioration in glaucoma suspects

      Cross-sectional study: Does combining optical coherence tomography measurements using the ‘Random Forest’ decision tree classifier improve the prediction of the presence of perimetric deterioration in glaucoma suspects

      Objectives To develop a classifier to predict the presence of visual field (VF) deterioration in glaucoma suspects based on optical coherence tomography (OCT) measurements using the machine learning method known as the ‘Random Forest’ algorithm. Design Case–control study. Participants 293 eyes of 179 participants with open angle glaucoma (OAG) or suspected OAG. Interventions Spectral domain OCT (Topcon 3D OCT-2000) and perimetry (Humphrey Field Analyser, 24-2 or 30-2 SITA standard) measurements were conducted in all of the participants. VF damage (Ocular Hypertension Treatment Study criteria (2002)) was used as a ‘gold-standard’ to classify glaucomatous eyes. The ‘Random Forest’ method was ...

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    1-13 of 13
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