Articles from www3.interscience.wiley.com

1. A new device for assessing changes in skin viscoelasticity using indentation and optical measurement

   Explore Article www3.interscience.wiley.com (Mar 10 2010) Dermatology

   Skin is a viscoelastic material, comprised of fluidic and fibrous components. Changes in viscoelasticity can arise due to a number of conditions including dehydration, swelling (associated with injury or disease), impaired heart function, rehydration therapy, ageing, scarring, sun exposure and genetic conditions affecting connective tissue. Quantification of changes in skin viscoelasticity due to these processes is of great clinical interest in the fields of therapy monitoring, wound healing and disease screening. However, devices currently available to measure aspects of the mechanical properties of skin have limitations in ease-of-use, accessibility, and depth of measurement. This paper describes a new technique to ... (Read Full Article)
   

   Comment on Article Mentions:   Imperial College London   University of Limerick

2. Clinical optical coherence tomography of early articular cartilage degeneration in persons with degenerative meniscal tears

   Explore Article www3.interscience.wiley.com (Mar 10 2010)

   Objective: Quantitative and nondestructive methods for clinical diagnosis and staging of articular cartilage degeneration are important to evaluation of potential disease modifying treatments for osteoarthritis. Optical Coherence Tomography (OCT) is a novel imaging technology that can generate microscopic resolution cross-sectional images of articular cartilage in near real time. This study tests the hypotheses that OCT can be used clinically to identify early cartilage degeneration, and that OCT correlates with MRI T2 values and arthroscopy. Methods: Patients undergoing arthroscopy for degenerative meniscal tears were recruited under IRB approved protocols. 30 consecutive subjects completing preoperative 3.0T MRI, arthroscopy, and intraoperative OCT comprised ... (Read Full Article)
   

   Comment on Article Mentions:   University of Pittsburgh   Constance R. Chu

3. Macular abnormalities in patients with retinitis pigmentosa: prevalence on OCT examination and outcomes of vitreoretinal surgery

   Explore Article www3.interscience.wiley.com (Mar 8 2010) Ophthalmology

   Purpose: To determine the prevalence of macular abnormalities detected by optical coherence tomography (OCT) in patients with retinitis pigmentosa (RP), and to report the results of pars plana vitrectomy (PPV) in five patients with RP.Methods: OCT images of the macula of 622 eyes of 323 patients with RP were evaluated. All patients had a complete clinical examination, and PPV was performed on two RP patients with a macular hole (MH), two patients with vitreomacular traction (VMT) syndrome, and one patient with cystoid macular oedema (CME).Results: A macular lesion was detected by OCT in 46 eyes (7.4%) of 37 patients (11.5%). ... (Read Full Article)
   

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4. Enhancement of permeability of glycerol with ultrasoundin human normal and cancer breast tissues in vitro using optical coherence tomography

   Explore Article www3.interscience.wiley.com (Mar 7 2010) Oncology

   Here we examined the effect of human normal breast (NB) and breast cancer (BC) tissues in vitro after treatment with glycerol in conjunction with ultrasound (surgeonperformed, SP) by OCT for functional imaging to monitor. 60% glycerol (G) and SP was simultaneously applied for 5 min. Depth- and time-resolved profiles for OCT signal enhancement were presented. The results show that OCT imaging depth of breast tissues after treatment with 60% G in combined with SP more obviously improved than that after application of glycerol alone. The permeability coefficient of 60% glycerol in 60% G/NB, 60% G/BC, 60% G/SP/NB, and 60% G/SP/BC ... (Read Full Article)
   

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5. Synergistic Effect of Ultrasound and Thiazone–PEG 400 on Human Skin Optical Clearing In Vivo

   Explore Article www3.interscience.wiley.com (Feb 22 2010) Dermatology

   In this paper, we propose a new physical method in combination with mixed solution of thiazone and polyethylene glycol 400 (thiazone PEG 400 solution) penetration into tissue to assess the skin optical clearing. Four treatments were performed: (1) control group (C); (2) polyethylene glycol 400 (PEG400); (3) 0.25% thiazone (0.25%T); (4) 0.25% thiazone and 5-min ultrasound (0.25%T/SP). The diffuse reflectance spectra and imaging depth of human skin in vivo at different times were measured by spectroscopy and optical coherence tomography (OCT). The optical clearing efficacy of skin was qualitatively and quantitatively analyzed. The results showed that the diffuse reflectance at ... (Read Full Article)
   

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6. Quantification of glycerol diffusion in human normal and cancer breast tissues in vitro with optical coherence tomography

   Explore Article www3.interscience.wiley.com (Feb 8 2010) Oncology , Probes

   Optical coherence tomography (OCT) holds great promise as a routine research tool for analysis of identifying the boundaries between normal and diseased breast tissue in vitro and in vivo. However, despite the depth penetration afforded by this imaging modality, light attenuation in tissues imposes limitations. Here we studied the optical clearing effect of glycerol in human cancer and normal breast tissues with OCT for functional imaging to monitor. Depth- and time-resolved profiles for OCT signal enhancement were presented. The results show that the OCT imaging depth and imaging contrast of breast tissues have been improved after application of 60% glycerol ... (Read Full Article)
   

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7. Plant photonics: application of optical coherence tomography to monitor defects and rots in onion

   Explore Article www3.interscience.wiley.com (Feb 8 2010) Other Non-Medical

   The incidence of physiological and/or pathological defects in many fresh produce types is still unacceptably high and accounts for a large proportion of waste. With increasing interest in food security their remains strong demand in developing reliable and cost effective technologies for non-destructive screening of internal defects and rots, these being deemed unacceptable by consumers. It is well recognized that the internal defects and structure of turbid scattering media can be effectively visualized by using optical coherence tomography (OCT). In the present study, the high spatial resolution and advantages of OCT have been demonstrated for imaging the skins and outer ... (Read Full Article)
   

   Comment on Article Mentions:   Igor V. Meglinski   Chittanon Buranachai   Prince of Songkla University

8. Sensitivity of confocal laser tomography versus optical coherence tomography in detecting advanced glaucoma

   Explore Article www3.interscience.wiley.com (Jan 23 2010) Ophthalmology

   Purpose: To determine the sensitivity of manufacturer supported normative algorithms in Heidelberg retinal tomography (HRT) and Stratus optical coherence tomography (OCT) in detecting advanced primary open angle glaucoma. Methods: A total of 157 subjects with advanced primary open angle glaucoma were recruited. The eye with the more severe glaucoma, as judged by mean deviation on Humphrey visual field, was imaged. The total number of optic disc sectors classified as being outside normal limits on Moorfields Regression Analysis (MRA) from the HRT II and HRT 3 software or from the sector and quadrant averages analysis of the Retinal Nerve Fiber Layer ... (Read Full Article)
   

   Comment on Article Mentions:   University of Melbourne   Heidelberg Engineering   Zeiss Stratus OCT

9. Optical and molecular techniques to identify tumor margins within the larynx

   Explore Article www3.interscience.wiley.com (Jan 22 2010) Otolaryngology

   Failure to remove tumor cells from the larynx significantly increases the risk of local recurrence following surgical excision. Healthy tissue must be preserved to optimize long-term vocal and swallowing function. It is essential to accurately distinguish between healthy mucosa, dysplasia, and invasive carcinoma. Optical and molecular examining technologies have been developed to improve tumor margin identification in vivo. We aimed to review the efficacy of these technologies. Published articles were identified using MEDLINE, EMBASE, and Cochrane central register of controlled trials (CENTRAL). Randomized clinical trials are required to establish the benefit to patients and cost to the health service of ... (Read Full Article)
   

   Comment on Article Mentions:   Gloucestershire Royal Hospital

10. Automated analysis of lesion depth and integrated reflectivity in PS-OCT scans of tooth demineralization

    Explore Article www3.interscience.wiley.com (Jan 16 2010) Dentistry

    Background and Objectives Several studies have demonstrated that polarization sensitive optical coherence tomography (PS-OCT) can be used to nondestructively measure the severity of subsurface demineralization in enamel and dentin, track lesion progression over time and measure remineralization. The purpose of this study was to develop methods for the automated assessment of the depth and severity of demineralization in PS-OCT scans. Materials and Methods Subsurface caries-like lesions of increasing depth and severity were produced in adjoining windows on 10 bovine enamel samples via exposure to demineralization for periods of 1-4 days. PS-OCT scans were acquired for each sample and analyzed using ... (Read Full Article)
    

    Comment on Article Mentions:   Cynthia L. Darling   Daniel S. Fried   Michael H. Le

11. Determination of ablation threshold for composite resins and amalgam irradiated with femtosecond laser pulses

    Explore Article www3.interscience.wiley.com (Jan 12 2010) Dentistry

    The use of laser for caries removal and cavity preparation is already a reality in the dental clinic. The objective of the present study was to consider the viability of ultrashort laser pulses for restorative material selective removal, by determining the ablation threshold fluence for composite resins and amalgam irradiated with femtosecond laser pulses. Lasers pulses centered at 830 nm with 50 fs of duration and 1 kHz of repetition rate, with energies in the range of 300 to 770 J were used to irradiate the samples. The samples were irradiated using two different geometrical methods for ablation threshold fluence ... (Read Full Article)
    

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12. Machine learning classifiers for glaucoma diagnosis based on classification of retinal nerve fibre layer thickness parameters measured by Stratus OCT

    Explore Article www3.interscience.wiley.com (Jan 8 2010) Ophthalmology

    Purpose: To compare the performance of two machine learning classifiers (MLCs), artificial neural networks (ANNs) and support vector machines (SVMs), with input based on retinal nerve fibre layer thickness (RNFLT) measurements by optical coherence tomography (OCT), on the diagnosis of glaucoma, and to assess the effects of different input parameters.Methods: We analysed Stratus OCT data from 90 healthy persons and 62 glaucoma patients. Performance of MLCs was compared using conventional OCT RNFLT parameters plus novel parameters such as minimum RNFLT values, 10th and 90th percentiles of measured RNFLT, and transformations of A-scan measurements. For each input parameter and MLC, the ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec

13. Reproducibility of retinal thickness measurements in patients with age-related macular degeneration using 3D Fourier-domain optical coherence tomography (OCT) (Topcon 3D-OCT 1000)

    Explore Article www3.interscience.wiley.com (Dec 21 2009) Ophthalmology

    Purpose: Conventional time-domain optical coherence tomography (OCT) has become an important tool for following dry or exudative age-related macular degeneration (AMD). Fourier-domain three-dimensional (3D) OCT was recently introduced. This study tested the reproducibility of 3D-OCT retinal thickness measurements in patients with dry and exudative AMD.Methods: Ten eyes with dry AMD and 12 eyes with exudative AMD were included in the study. Sets of three OCT 6 × 6-mm raster scans were taken by one operator. Mean retinal thickness was calculated for 36 areas. Coefficients of variation (CoV) were calculated for each patient and area. For analysis, two separate areas (central ... (Read Full Article)
    

    Comment on Article Mentions:   Topcon Medical Systems   Topcon 3D OCT-1000   University of Zurich

14. The Nature of the Extraordinary Finish of Stradivaris Instruments

    Explore Article www3.interscience.wiley.com (Dec 13 2009) Art

    The composition of Stradivari\9s varnish has raised numerous hypotheses and controversies for the past two centuries, although a clear understanding of the materials could not be reached. In their Communication (DOI: 10.1002/anie.200905131), J.-P. Echard et al. describe the chemical stratigraphy of the varnishes from five representative Stradivari instruments by using a wide array of analytical techniques. In particular, Stradivari used several red pigments, and may have sought a variety of tints to give his instruments their beautiful appearance. (Read Full Article)
    

    Comment on Article Mentions:   Jean-Philippe Echard   Stéphane Vaiedelich   Balthazar Soulier

15. Spontaneous closure of lamellar macular holes studied by optical coherence tomography

    Explore Article www3.interscience.wiley.com (Dec 9 2009) Ophthalmology

    Purpose: To document and study the spontaneous closure of lamellar macular holes (LMH) by optical coherence tomography (OCT).Methods: Two women with LMH, 62 and 71 years old, respectively, were followed up with fundoscopy, fundus photography and OCT.Results: In both patients spontaneous closure of LMH was observed 11 and 21 months after baseline examination, respectively. The foveal thickness in case 1 increased from 84 [mu]m at baseline to 162 [mu]m at the final examination. The foveal thickness in case 2 increased from 48 [mu]m at baseline to 148 [mu]m at the final examination. The foveal contour was also restored in both ... (Read Full Article)
    

    Comment on Article Mentions:   University of Athens

16. Macular haemorrhage after repetitive roller coaster riding

    Explore Article www3.interscience.wiley.com (Nov 24 2009) Ophthalmology

    No Abstract Provided (Read Full Article)
    

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17. In vivo imaging of the cyclic changes in cross-sectional shape of the ventricular segment of pulsating embryonic chick hearts at stages 14 to 17: A contribution to the understanding of the ontogenesis of cardiac pumping function

    Explore Article www3.interscience.wiley.com (Nov 20 2009) Developmental Biology

    The cardiac cycle-related deformations of tubular embryonic hearts were traditionally described as concentric narrowing and widening of a tube of circular cross-section. Using optical coherence tomography (OCT), we have recently shown that, during the cardiac cycle, only the myocardial tube undergoes concentric narrowing and widening while the endocardial tube undergoes eccentric narrowing and widening, having an elliptic cross-section at end-diastole and a slit-shaped cross-section at end-systole. Due to technical limitations, these analyses were confined to early stages of ventricular development (chick embryos, stages 10-13). Using a modified OCT-system, we now document, for the first time, the cyclic changes in cross-sectional ... (Read Full Article)
    

    Comment on Article Mentions:   Technical University of Denmark   Lars Thrane

18. Characteristics and reproducibility of anterior chamber angle assessment by anterior-segment optical coherence tomography

    Explore Article www3.interscience.wiley.com (Nov 19 2009) Ophthalmology

    Purpose: To evaluate the basic characteristics and reproducibility of anterior chamber angle (ACA) measurements determined by anterior-segment optical coherence tomography (AS-OCT) in open-angle and primary angle closure suspect (PACS) patients. Methods: Thirty-nine open-angle and 18 PACS patients were imaged for ACA by AS-OCT. Subjects underwent imaging of the nasal, temporal and inferior ACA under conditions of constant light, and darkness. For analysis, we used three ACA parameters handled by the Visante OCT software: angle opening distance at 500 μm (AOD500), trabecular-iris space area at 500 μm (TISA500) and angle recess area at 500 μm (ARA500). For determination of inter-session reproducibility, ... (Read Full Article)
    

    Comment on Article Mentions:   University of Ulsan   Sung Yong Kang   Zeiss Visante OCT

19. Multimodality bronchoscopic imaging of recurrent respiratory papillomatosis

    Explore Article www3.interscience.wiley.com (Nov 18 2009) Bronchoscopy

    Objectives/Hypothesis. Recurrent respiratory papillomatosis (RRP) of the central airways requires removal to potentially reduce recurrence and risk for malignant transformation. Analogous to the principles of treatment for early lung cancer, a precise determination of the extent of cartilage invasion could help guide therapeutic decisions and monitor response to treatment. The purpose of this study was to determine whether a bronchoscopy platform comprised of white light bronchoscopy (WLB), endobronchial ultrasound (EBUS), and optical coherence tomography (OCT) could identify layered microstructure of RRP and underlying cartilage. Study Design. Case study. Methods. A bronchoscopy platform consisting of commercially available WLB, EBUS using a ... (Read Full Article)
    

    Comment on Article Mentions:   UC Irvine   University of Ulsan   Matthew Brenner

20. Macular changes detected by Fourier-domain optical coherence tomography in patients with hypotony without clinical maculopathy

    Explore Article www3.interscience.wiley.com (Nov 10 2009) Ophthalmology

    Purpose: To investigate macular changes in eyes with postoperative hypotony without clinical maculopathy using high-resolution Fourier-domain optical coherence tomography (FD-OCT).Methods: Fourteen eyes of 12 patients with postoperative intraocular pressure (IOP) [le] 6 mmHg for at least 4 weeks but with no detectable clinical features associated with hypotony maculopathy were imaged by FD-OCT prospectively. Images were analysed by two retina specialists masked to clinical findings.Results: Most patients were female (83%) and myopic (75%) with a mean age of 65 ± 17 [standard deviation (SD)] years (range 2[ndash]86 years). Mean central corneal thickness was 519 ± 34 [mu]m [95% confidence interval (CI) ... (Read Full Article)
    

    Comment on Article Mentions:   Robert Ritch   New York Eye and Ear Infirmary   Richard B. Rosen

21. Fundus autofluorescence in patients with blunt ocular trauma

    Explore Article www3.interscience.wiley.com (Nov 10 2009) Ophthalmology

    Purpose: To report fundus autofluorescence and optical coherence tomography (OCT) findings in patients with blunt ocular trauma.Methods: Six eyes of six consecutive patients with blunt ocular trauma were evaluated in an observational case series using colour fundus photography, the Heidelberg Retina Angiograph 2 (HRA2) system for fundus autofluorescence (FAF) and OCT (Stratus OCT).Results: Three patients presented with secondary retinal pigment epitheliopathy that was identified as a reduced FAF plaque with interposed increased FAF granular smaller lesions. These findings were not as evident in fundus examination and colour photography in two patients. Visual field in one patient showed a decreased area ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Universidade Federal de São Paulo   Carl Zeiss Meditec

22. Intrasession repeatability of optical coherence tomography measures in active neovascular age-related macular degeneration

    Explore Article www3.interscience.wiley.com (Nov 9 2009) Ophthalmology

    Objectives: To determine the repeatability of Stratus optical coherence tomography fast macular thickness map analysis in patients with active neovascular age-related macular degeneration (nAMD).Methods: Consecutive pairs of scans from 112 eyes of 112 consecutive patients with active nAMD were analyzed. The Bland[ndash]Altman coefficient of repeatability (CR) was calculated for each retinal thickness or volume measure.Results: The CR for the central 1 mm macular subfield was 59 [mu]m (18% of retinal thickness) and did not exceed 69 [mu]m in any subfield. There was much poorer repeatability for the center-point thickness (CPT) measure (CR of 78 [mu]m; 24%). However, in the subgroup ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec   Adnan Tufail

23. Evaluation of anterior-segment inflammation and retinal thickness change following cataract surgery

    Explore Article www3.interscience.wiley.com (Oct 29 2009) Ophthalmology

    Purpose: To investigate the physiological retinal response to uneventful cataract surgery using conventional time-domain (TD-OCT) and current spectral-domain optical coherence tomography (SD-OCT) in combination with an assessment of the anterior chamber inflammatory reaction by laser flare/cell meter (LCFM).Methods: Thirty-four patients scheduled for cataract surgery were included in this prospective pilot study. Retinal parameters were examined according to a standardized examination procedure using TD-OCT (Stratus; Carl Zeiss Meditec, Dublin, California, USA) and SD-OCT (Cirrus; Carl Zeiss Meditec) devices. The inflammatory reaction of the anterior chamber was measured by LFCM (Kowa FC-1000, Kowa Co. Ltd, Tokyo, Japan). Examinations were carried out preoperatively ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec   Zeiss Cirrus HD-OCT

24. Retinal nerve fibre layer thickness in full-term children assessed with Heidelberg retinal tomography and optical coherence tomography: normal values and interocular asymmetry

    Explore Article www3.interscience.wiley.com (Oct 29 2009) Ophthalmology

    Purpose: This study aimed to investigate normal values and interocular differences in retinal nerve fibre layer (RNFL) thickness, using optical coherence tomography (OCT) and Heidelberg retinal tomography (HRT), in 5[ndash]16-year-old children born at full-term with normal birthweights.Methods: Fifty-six children with normal visual acuity and refraction were examined with Stratus OCT and HRT. Three examinations were performed in each eye. One eye in each child was randomized for analyses of normal values. Findings in 54 eyes were evaluated. Mean values of RNFL thickness were calculated. Coefficients of variance and intraclass correlations were calculated. The correlation between right and left eyes and ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec

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