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    1. Effect of age on anterior chamber angle configuration in Asians determined by anterior segment optical coherence tomography; clinic-based study

      Effect of age on anterior chamber angle configuration in Asians determined by anterior segment optical coherence tomography; clinic-based study
      Purpose: To evaluate the distribution of anterior chamber angle (ACA) parameters and to assess association of these parameters with age in Asian subjects. Methods: Four hundred and thirty-nine consecutive Korean subjects aged from 30 to 89 were enrolled from a university clinic. All participants were scanned using anterior segment optical coherence tomography (AS-OCT, Visante, version 2.0). We measured ACA parameters such as anterior chamber depth (ACD), angle opening distance at 500 and 750 μm (AOD500,750), angle recess area at 500 and 750 μm (ARA500,750), trabecular iris space area at 500 and 750 μm (TISA500,750), and determined ...
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    2. Performance of OCT segmentation procedures to assess morphology and extension in geographic atrophy

      Performance of OCT segmentation procedures to assess morphology and extension in geographic atrophy
      Purpose: Investigating segmentation procedures and morphological findings in time domain (TD) and current spectral domain (SD) optical coherence tomography (OCT) devices in patients with geographic atrophy (GA).Methods: Fifty eyes of 46 patients with GA secondary to AMD and 15 control eyes were examined in this prospective noninterventional comparative case series. All patients underwent Stratus (model 3000), Cirrus (Carl Zeiss Meditec), Spectralis (Spectralis HRA+OCT; Heidelberg Engineering) and 3D-OCT-1000 (Topcon). Automated segmentation analyses were compared. An overlay of scanning laser ophthalmoscope (SLO) and three-dimensional retinal thickness (RT) maps were used to investigate whether areas of retinal thinning correspond to areas ...
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    3. Using swept-source optical coherence tomography to monitor the formation of neo-epidermis in tissue-engineered skin

      Using swept-source optical coherence tomography to monitor the formation of neo-epidermis in tissue-engineered skin

      There is an increasing need for a robust, simple to use, non-invasive imaging technology to follow tissue-engineered constructs as they develop. Our aim was to evaluate the use of swept-source optical coherence tomography (SS-OCT) to image tissue-engineered skin as it developed over several weeks. Tissue-engineered skin was produced using both de-epithelialized acellular dermis (DED) and amorphous collagen gels. In both cases the epidermis could be readily distinguished from the neodermis, based on a comparison with standard destructive histology of samples. Constructs produced with DED showed more epidermal/dermal maturation than those produced using collagen. The development of tissue-engineered skin based ...

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    4. Multimodal imaging guidance for laser ablation in tracheal stenosis

      Multimodal imaging guidance for laser ablation in tracheal stenosis
      Objective/Hypothesis: Laser-induced damage of tracheal wall microstructures might contribute to recurrence after bronchoscopic treatment of tracheal strictures. The purpose of this study was to demonstrate how multimodal imaging using white light bronchoscopy (WLB), endobronchial ultrasound (EBUS), and optical coherence tomography (OCT) might identify in vivo airway wall changes before and resulting from Nd:YAG laser ablation and dilation of tracheal stenosis. Study Design: Case study. Methods: Commercially available WLB, high frequency EBUS using a 20-MHz radial probe and time-domain, frontal imaging OCT systems were used to characterize the extent, morphology, and airway wall microstructures at the area of hypertrophic ...
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    5. Bioengineering and subjective approaches to the clinical evaluation of dry skin

      Bioengineering and subjective approaches to the clinical evaluation of dry skin
      Dry skin (also known as xerosis) is a cutaneous reaction pattern indicative of abnormal desquamation, which has not only cosmetic considerations, but can also lead to the penetration of irritants and allergens through the stratum corneum (SC). Over the last few decades, our understanding of the structure, composition, formation and function of the SC has advanced tremendously; however, despite these advancements, the occurrence of dry skin remains prevalent in the adult population. The clinical evaluation of dry skin is therefore of significant importance to the cosmetic industry not only for understanding the condition but also for measuring the effects of ...
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    6. Changes in Caucasian eyes after laser peripheral iridotomy: an anterior segment optical coherence tomography study

      Changes in Caucasian eyes after laser peripheral iridotomy: an anterior segment optical coherence tomography study
      Background: To evaluate by anterior segment optical coherence tomography (AS-OCT) the changes in the anterior chamber structures in Caucasian eyes after laser peripheral iridotomy (PI). Methods: Retrospective study of consecutive Caucasian primary angle closure suspect (PACS), primary angle closure (PAC) or primary angle closure glaucoma (PACG) patients who underwent laser PI over a 25-month period at a specialist glaucoma practice. The AS-OCT images of the temporal and nasal angles (in light and dark) before and after laser PI were analysed. The parameters studied were trabecular-iris angle (TIA), angle opening distance (AOD), trabecular-iris space area (TISA), trabecular-iris contact length (TICL), iris ...
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    7. Dynamic imaging of vocal fold oscillation with four-dimensional optical coherence tomography

      Dynamic imaging of vocal fold oscillation with four-dimensional optical coherence tomography

      Optical coherence tomography (OCT) can provide high-resolution ([sim]10-15 [mu]m/pixel) images of vocal fold microanatomy, as demonstrated previously. We explored physiologically triggered Fourier-domain OCT for imaging vocal folds during phonation. The goal is to visualize dynamic histological cross sections and four-dimensional data sets where multiple planes are displayed in synchronized motion. If feasible, this approach could be a useful research tool and spur development of new clinical instrumentation.A Fourier-domain, triggered OCT system was created and tested in experiments on excised calf larynges to obtain preliminary observations and characterize important factors affecting image quality.Larynges were imaged during ...

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    8. Analysis of spectral domain optical coherence tomography findings in occult macular dystrophy

      Analysis of spectral domain optical coherence tomography findings in occult macular dystrophy
      Purpose: To describe findings of spectral domain optical coherence tomography (SD-OCT) in the diagnosis of occult macular dystrophy (OMD).Materials and Methods: Five visually disturbed patients who had shown normal findings in full field electroretinogram (ERG), fundus photography and fluorescein angiography but abnormal findings in multifocal ERG had undergone SD-OCT. The morphologic changes in retina and macular thickness were detected and imaged by SD-OCT. We analysed the results of SD-OCT including macular thickness, inner segment and outer segment (IS/OS) boundary and external limiting membrane (ELM).Results: Mean age was 41.6 (22[ndash]63) in three male and two ...
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    9. Measurement of central corneal thickness by high-resolution Scheimpflug imaging, Fourier-domain optical coherence tomography and ultrasound pachymetry

      Measurement of central corneal thickness by high-resolution Scheimpflug imaging, Fourier-domain optical coherence tomography and ultrasound pachymetry
      Purpose: To compare the repeatability and reproducibility of central corneal thickness (CCT) measurements by high-resolution (HR) rotating Scheimpflug imaging and Fourier-domain optical coherence tomography (FD-OCT). CCT measurements were compared to those determined by ultrasound pachymetry (UP).Methods: In 35 healthy eyes, intra-observer repeatability for HR Scheimpflug (Pentacam) and FD-OCT (RTVue) systems was determined in consecutive images taken by an observer in the shortest time possible. Imaging was repeated again by a second observer to evaluate inter-observer reproducibility. The CCT measurements were compared among Scheimpflug, FD-OCT and UP images.Results: Mean coefficients of repeatability were 0.48% for Scheimpflug and 0 ...
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    10. Preliminary investigation on use of high-resolution optical coherence tomography to monitor injury and repair in the rat sciatic nerve

      Preliminary investigation on use of high-resolution optical coherence tomography to monitor injury and repair in the rat sciatic nerve
      Background and Objective Optical coherence tomography (OCT) has been used in limited settings to study peripheral nerve injury. The purpose of the study is to determine whether high-resolution OCT can be used to monitor nerve injury and regeneration in the rat sciatic nerve following crush injury, ligation, and transection with microsurgical repair. Study Design/Materials and Methods Forty-five rats were segregated into three groups. The right sciatic nerve was suture ligated (n = 15), cut then microsurgically repaired (n = 15), or crushed (n = 15). The left sciatic nerve served as the control; only surgical exposure and skin closure were performed. Each ...
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    11. Characterization of enamel in primary teeth by optical coherence tomography for assessment of dental caries

      Characterization of enamel in primary teeth by optical coherence tomography for assessment of dental caries
      Background. Caries is a disease that affects both primary and permanent dentitions, therefore new methods of caries diagnosis need to be tested on primary teeth as well as on permanent teeth. Aim. This study reports the application of optical coherence tomography (OCT) to characterize sound dental structure and detect natural caries of human primary teeth. Design. Six primary teeth were sectioned into thin slices (∼1.5 mm), and analysed perpendicular to the enamel surface by two home-made OCT systems operating around 1280 and 840 nm. The generated images were compared with histology as the gold standard. Results. We demonstrated the ...
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    12. Non-invasive assessment of healing of bacteria infected and uninfected wounds using optical coherence tomography

      Non-invasive assessment of healing of bacteria infected and uninfected wounds using optical coherence tomography
      Bacterial infection is one of the main predisposing factors for the delay in wound healing. To facilitate a timely decision for correct therapy, it is important to accurately monitor the morphological changes in the infected wounds using noninvasive tools. In the present study, we have explored the use of optical coherence tomography (OCT) for monitoring the healing of superficial wounds infected with Staphylococcus aureus in mice under in vitro and in vivo conditions and studied the changes in collagen birefringence in the infected wounds. The tape stripping method was used for generating superficial skin wounds in mice and wounds were ...
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    13. A new device for assessing changes in skin viscoelasticity using indentation and optical measurement

      A new device for assessing changes in skin viscoelasticity using indentation and optical measurement
      Skin is a viscoelastic material, comprised of fluidic and fibrous components. Changes in viscoelasticity can arise due to a number of conditions including dehydration, swelling (associated with injury or disease), impaired heart function, rehydration therapy, ageing, scarring, sun exposure and genetic conditions affecting connective tissue. Quantification of changes in skin viscoelasticity due to these processes is of great clinical interest in the fields of therapy monitoring, wound healing and disease screening. However, devices currently available to measure aspects of the mechanical properties of skin have limitations in ease-of-use, accessibility, and depth of measurement. This paper describes a new technique to ...
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    14. Clinical optical coherence tomography of early articular cartilage degeneration in persons with degenerative meniscal tears

      Clinical optical coherence tomography of early articular cartilage degeneration in persons with degenerative meniscal tears
      Objective: Quantitative and nondestructive methods for clinical diagnosis and staging of articular cartilage degeneration are important to evaluation of potential disease modifying treatments for osteoarthritis. Optical Coherence Tomography (OCT) is a novel imaging technology that can generate microscopic resolution cross-sectional images of articular cartilage in near real time. This study tests the hypotheses that OCT can be used clinically to identify early cartilage degeneration, and that OCT correlates with MRI T2 values and arthroscopy. Methods: Patients undergoing arthroscopy for degenerative meniscal tears were recruited under IRB approved protocols. 30 consecutive subjects completing preoperative 3.0T MRI, arthroscopy, and intraoperative OCT ...
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    15. Macular abnormalities in patients with retinitis pigmentosa: prevalence on OCT examination and outcomes of vitreoretinal surgery

      Macular abnormalities in patients with retinitis pigmentosa: prevalence on OCT examination and outcomes of vitreoretinal surgery
      Purpose: To determine the prevalence of macular abnormalities detected by optical coherence tomography (OCT) in patients with retinitis pigmentosa (RP), and to report the results of pars plana vitrectomy (PPV) in five patients with RP.Methods: OCT images of the macula of 622 eyes of 323 patients with RP were evaluated. All patients had a complete clinical examination, and PPV was performed on two RP patients with a macular hole (MH), two patients with vitreomacular traction (VMT) syndrome, and one patient with cystoid macular oedema (CME).Results: A macular lesion was detected by OCT in 46 eyes (7.4%) of ...
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    16. Enhancement of permeability of glycerol with ultrasoundin human normal and cancer breast tissues in vitro using optical coherence tomography

      Enhancement of permeability of glycerol with ultrasoundin human normal and cancer breast tissues in vitro using optical coherence tomography
      Here we examined the effect of human normal breast (NB) and breast cancer (BC) tissues in vitro after treatment with glycerol in conjunction with ultrasound (surgeonperformed, SP) by OCT for functional imaging to monitor. 60% glycerol (G) and SP was simultaneously applied for 5 min. Depth- and time-resolved profiles for OCT signal enhancement were presented. The results show that OCT imaging depth of breast tissues after treatment with 60% G in combined with SP more obviously improved than that after application of glycerol alone. The permeability coefficient of 60% glycerol in 60% G/NB, 60% G/BC, 60% G/SP ...
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    17. Synergistic Effect of Ultrasound and Thiazone–PEG 400 on Human Skin Optical Clearing In Vivo

      Synergistic Effect of Ultrasound and Thiazone–PEG 400 on Human Skin Optical Clearing In Vivo

      In this paper, we propose a new physical method in combination with mixed solution of thiazone and polyethylene glycol 400 (thiazone PEG 400 solution) penetration into tissue to assess the skin optical clearing. Four treatments were performed: (1) control group (C); (2) polyethylene glycol 400 (PEG400); (3) 0.25% thiazone (0.25%T); (4) 0.25% thiazone and 5-min ultrasound (0.25%T/SP). The diffuse reflectance spectra and imaging depth of human skin in vivo at different times were measured by spectroscopy and optical coherence tomography (OCT). The optical clearing efficacy of skin was qualitatively and quantitatively analyzed. The ...

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    18. Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis

      Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis

      Objective Cross-sectional studies of optical coherence tomography (OCT) show that retinal nerve fiber layer (RNFL) thickness is reduced in multiple sclerosis (MS) and correlates with visual function. We determined how longitudinal changes in RNFL thickness relate to visual loss. We also examined patterns of RNFL thinning over time in MS eyes with and without a prior history of acute optic neuritis (ON). Methods Patients underwent OCT measurement of RNFL thickness at baseline and at 6-month intervals during a mean follow-up of 18 months at 3 centers. Low-contrast letter acuity (2.5%, 1.25% contrast) and visual acuity (VA) were assessed ...

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    19. Quantification of glycerol diffusion in human normal and cancer breast tissues in vitro with optical coherence tomography

      Quantification of glycerol diffusion in human normal and cancer breast tissues in vitro with optical coherence tomography
      Optical coherence tomography (OCT) holds great promise as a routine research tool for analysis of identifying the boundaries between normal and diseased breast tissue in vitro and in vivo. However, despite the depth penetration afforded by this imaging modality, light attenuation in tissues imposes limitations. Here we studied the optical clearing effect of glycerol in human cancer and normal breast tissues with OCT for functional imaging to monitor. Depth- and time-resolved profiles for OCT signal enhancement were presented. The results show that the OCT imaging depth and imaging contrast of breast tissues have been improved after application of 60% glycerol ...
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    20. Plant photonics: application of optical coherence tomography to monitor defects and rots in onion

      Plant photonics: application of optical coherence tomography to monitor defects and rots in onion
      The incidence of physiological and/or pathological defects in many fresh produce types is still unacceptably high and accounts for a large proportion of waste. With increasing interest in food security their remains strong demand in developing reliable and cost effective technologies for non-destructive screening of internal defects and rots, these being deemed unacceptable by consumers. It is well recognized that the internal defects and structure of turbid scattering media can be effectively visualized by using optical coherence tomography (OCT). In the present study, the high spatial resolution and advantages of OCT have been demonstrated for imaging the skins and ...
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    21. Sensitivity of confocal laser tomography versus optical coherence tomography in detecting advanced glaucoma

      Sensitivity of confocal laser tomography versus optical coherence tomography in detecting advanced glaucoma
      Purpose: To determine the sensitivity of manufacturer supported normative algorithms in Heidelberg retinal tomography (HRT) and Stratus optical coherence tomography (OCT) in detecting advanced primary open angle glaucoma. Methods: A total of 157 subjects with advanced primary open angle glaucoma were recruited. The eye with the more severe glaucoma, as judged by mean deviation on Humphrey visual field, was imaged. The total number of optic disc sectors classified as being outside normal limits on Moorfields Regression Analysis (MRA) from the HRT II and HRT 3 software or from the sector and quadrant averages analysis of the Retinal Nerve Fiber Layer ...
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    22. Optical and molecular techniques to identify tumor margins within the larynx

      Optical and molecular techniques to identify tumor margins within the larynx
      Failure to remove tumor cells from the larynx significantly increases the risk of local recurrence following surgical excision. Healthy tissue must be preserved to optimize long-term vocal and swallowing function. It is essential to accurately distinguish between healthy mucosa, dysplasia, and invasive carcinoma. Optical and molecular examining technologies have been developed to improve tumor margin identification in vivo. We aimed to review the efficacy of these technologies. Published articles were identified using MEDLINE, EMBASE, and Cochrane central register of controlled trials (CENTRAL). Randomized clinical trials are required to establish the benefit to patients and cost to the health service of ...
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