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    1. Development of a Photographic Scale for Consistency and Guidance in Dermatologic Assessment of Forearm Sun Damage

      Development of a Photographic Scale for Consistency and Guidance in Dermatologic Assessment of Forearm Sun Damage
      Objectives To develop a photographic sun damage assessment scale for forearm skin and test its feasibility and utility for consistent classification of sun damage. Design For a blinded comparison, 96 standardized 8 x 10 digital photographs of participants' forearms were taken. Photographs were graded by an expert dermatologist using an existing 9-category dermatologic assessment scoring scale until all categories contained photographs representative of each of 4 clinical signs. Triplicate photographs were provided in identical image sets to 5 community dermatologists for blinded rating using the dermatologic assessment scoring scale. Setting Academic skin cancer prevention clinic with high-level experience in assessment ...
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    2. Optical Biopsy at the Bedside

      Optical Biopsy at the Bedside
      Skin biopsy is essential for the diagnosis of many cutaneous conditions. Beyond the cost and technical considerations, it is an invasive, painful, and scarring procedure. These factors lead dermatologists to be selective about what and when we biopsy, resulting in potential delay and misdiagnosis. Biopsy also is subject to sampling error; because it changes the tissue permanently, it is not amenable to longitudinal evaluation. Because specimen processing creates a delay, some treatment options are limited. Hence, there is a need to develop new noninvasive methods to permit immediate microscopic visualization of tissues in vivo or ex vivo. One might consider ...
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    3. Three-Dimensional Images and Vessel Rendering Using Optical Coherence Tomography

      Optical coherence tomography (OCT) is an emerging technology in dermatology. Translating the principles of ultrasound to use with light waves, OCT captures in vivo images allowing for 3-dimensional reconstruction and Doppler flow measurements. Compared with confocal microscopy, standard OCT has a greater depth of penetration but lower resolution. This places the technology between traditional ultrasound and confocal microscopy in the trade-off between depth penetration and surface resolution (Figure 1). Optical coherence tomography creates an image by splitting an infrared laser into a reference arm and a sample arm (Figure 2). The sample arm scans a designated region of skin, and ...
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