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    1. Application of functional optical coherence tomography angiography in neurovascular research (Thesis)

      Application of functional optical coherence tomography angiography in neurovascular research (Thesis)

      Optical coherence tomography (OCT) is a revolutionary non-invasive imaging technique that can perform high-resolution, cross-sectional tomographic imaging of the internal microstructure in biological tissues by measuring backscattered or backreflected light. Its functional extension, OCT angiography (OCTA), analyzes the intrinsic scattering property of the heterogenous tissue bed to extract dynamic blood flow signals to the capillary level without a need of contrast agents. Aside from the commonly known application of OCTA in clinical ophthalmology for imaging the retinal blood flow in human subjects, the technique has recently emerged as a useful tool in pre-clinical neuroscience for imaging cerebral microcirculation and dynamics ...

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    2. Ophthalmic Application of Optical Coherence Tomography Based Angiography for Choroidal Imaging (Thesis)

      Ophthalmic Application of Optical Coherence Tomography Based Angiography for Choroidal Imaging (Thesis)

      We demonstrated in vivo choriocapillaris imaging in normal human subjects with a Cirrus HD 5000 spectral domain OCT prototype. With the tracking system installed in the prototype and the montage scanning protocol, wide field OCT angiograms of 9 mm * 11 mm were created. OCT angiography utilizes the intrinsic motion of red blood cells as contrast mechanism therefore requires no exogenous contrast agents as fluorescein angiography and indocyanine green angiography do. Four consecutive OCT scans were acquired at the same location for angiography generating, intensity based, phase based and complex signal based OCTA were all computed and compared. With the ability ...

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    3. Development of Spectral Domain Optical Coherence Tomography for in vivo Functional Imaging of Biological Tissues (Thesis)

      Development of Spectral Domain Optical Coherence Tomography for in vivo Functional Imaging of Biological Tissues (Thesis)

      Optical coherence tomography is a rapidly developing optical imaging modality capable of noninvasively providing depth resolved information of biological tissue at micrometer scale. Since its first report in 1991, it has made tremendous progress leading to successful applications in a number of fields, such as ophthalmology, gastroenterology, dermatology, dentistry, dermatology, cardiology, etc. According to [1], there are more than 15, 000 OCT units that had been put into service in ophthalmic clinic by 2009, which represented approximately $ 1 billion market. The total amount paid by Medicare for OCT scans has increased from $ 1 billion per year in 2001 to $ 7 ...

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    1-3 of 3
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