Articles from SpringerLink Home

1. Nanoshells for Photothermal Cancer Therapy

   Explore Article SpringerLink Home (Mar 11 2010) Oncology

   Cancer is a leading cause of death in the United States and contributes to yearly rising health care costs. Current methods of treating cancer involve surgical removal of easily accessible tumors, radiation therapy, and chemotherapy. These methods do not always result in full treatment of the cancer and can in many cases damage healthy cells both surrounding the tissue area and systemically. Nanoshells are optically tunable core/shell nanoparticles that can be fabricated to strongly absorb in the near-infrared (NIR) region where light transmits deeply into tissue. When injected systemically, these particles have been shown to accumulate in the tumor due ... (Read Full Article)
   

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2. Gold Nanorods: Multifunctional Agents for Cancer Imaging and Therapy

   Explore Article SpringerLink Home (Mar 11 2010) Oncology

   Gold nanorods (GNRs) are strongly absorbing at near-infrared (NIR) frequencies and can be employed as multifunctional agents for biological imaging and theragnostics. GNRs can support nonlinear optical microscopies based on two-photon-excited luminescence and can enhance the contrast of biomedical imaging modalities such as optical coherence tomography and photoacoustic tomography. GNRs are also efficient at mediating the conversion of NIR light energy into heat and can generate localized photothermal effects. However, future clinical applications will require the rigorous removal of CTAB, a micellar surfactant used in GNR synthesis, and reliable methods of surface functionalization for cell-selective targeting and for minimizing nonspecific ... (Read Full Article)
   

   Comment on Article Mentions:   Purdue University   Alexander Wei

3. Visualization and follow-up of acute macular neuroretinopathy with the Spectralis® HRA + OCT device

   Explore Article SpringerLink Home (Mar 3 2010) Ophthalmology

   Abstract Background Acute macular neuroretinopathy (AMNR) is a rare disease entity, the diagnosis of which is frequently complicated by the subtlety of biomicroscopic findings. Methods Two cases of AMNR are presented, in which the diagnosis and follow-up was enabled using the Spectralis® HRA+OCT in the absence of clear biomicroscopic findings. Results The typical lesions were visualized by hyporeflexion during infrared imaging and faded over time. With spectral domain optical coherence tomography, changes in the outer retina in the affected regions were documented, with no change over time. Conclusion The broader availability of this technology may enhance the diagnosis and follow-up ... (Read Full Article)
   

   Comment on Article Mentions:   Heidelberg Spectralis   Heidelberg Engineering

4. Optic Nerve: Optical Coherence Tomography

   Explore Article SpringerLink Home (Mar 2 2010) Ophthalmology

   The Stratus OCT (Carl Zeiss Meditec, Inc., Dublin, CA) is the predominant time-domain OCT in clinical use at the time of this writing. A variety of scan patterns (radial or circular) can be acquired with this device to image the area of interest. The “Fast Optic Disc” pattern is used to analyze the optic nerve head. The “Fast Optic Disc” pattern consists of six evenly spaced radial lines centered on the ONH (see Fig. 5.4a). Each of the six lines is made of 128 A-scans (vertically scanned sampling points), crossing an area of 4.0 mm in length, and the total ... (Read Full Article)
   

   Comment on Article Mentions:   University of Pittsburgh   Zeiss Stratus OCT   Carl Zeiss Meditec

5. Measurement of retinal nerve fiber layer thickness in optic atrophy eyes of patients with optic neuritis using optical coherence tomography

   Explore Article SpringerLink Home (Feb 26 2010) Ophthalmology

   Abstract Objective  To measure the retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) in optic atrophy eyes of patients with optic neuritis and investigate the correlation between the RNFL thickness and the visual function. Methods  To compare the RNFL thickness using StratusOCT, three groups of the subjects were enrolled, including 72 patients with optic atrophy with definite demyelinating optic neuritis history (the neuritis group), 47 patients with advanced POAG atrophic neuropathy (the POAG group), and 47 healthy subjects (the control group). The correlation between the RNFL thickness and visual function parameters were investigated in the neuritis group, including the ... (Read Full Article)
   

   Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec

6. Comparison of full-thickness traumatic macular holes and idiopathic macular holes by optical coherence tomography

   Explore Article SpringerLink Home (Feb 24 2010) Ophthalmology

   Background The optical coherence tomography (OCT) and clinical characteristics of traumatic macular holes (TMHs) can be compared to those of idiopathic macular holes (IMHs) to gain insights into the pathogenesis of both. Methods The demographic data and visual acuity of 73 consecutive patients with unilateral, full-thickness TMHs and 182 consecutive patients with idiopathic IMHs were recorded. All patients with TMH and 60 patients with IMH underwent OCT scanning and quantitative measurements. The apical and basal diameters and marginal retinal thicknesses were recorded for each hole. The hole areas and eccentricities were calculated. These parameters were compared between the two types ... (Read Full Article)
   

   Comment on Article Mentions:   Sun Yat-Sen University   Keck School of Medicine   Srinivas R. Sadda

7. Reproducibility of peripapillary retinal nerve fiber layer thickness with spectral domain cirrus high-definition optical coherence tomography in normal eyes

   Explore Article SpringerLink Home (Feb 12 2010) Ophthalmology

   Abstract Purpose  To assess the reproducibility of the new spectral domain Cirrus high-definition optical coherence tomography (HD-OCT; Carl Zeiss Meditec, Dublin, CA, USA) for analysis of peripapillary retinal nerve fiber layer (RNFL) thickness in healthy eyes. Methods  Thirty healthy Korean volunteers were enrolled. Three optic disc cube 200 × 200 Cirrus HD-OCT scans were taken on the same day in discontinuous sessions by the same operator without using the repeat scan function. The reproducibility of the calculated RNFL thickness and probability code were determined by the intraclass correlation coefficient (ICC), coefficient of variation (CV), test-retest variability, and Fleiss’ generalized kappa (κ). Results  Thirty-six ... (Read Full Article)
   

   Comment on Article Mentions:   Zeiss Stratus OCT   Yonsei University   Zeiss Cirrus HD-OCT

8. Peripapillary retinal nerve fiber layer thickness in normal Japanese eyes measured with optical coherence tomography

   Explore Article SpringerLink Home (Feb 12 2010) Ophthalmology

   Abstract Purpose  To measure peripapillary retinal nerve fiber layer (RNFL) thickness in healthy Japanese individuals using optical coherence tomography (OCT). Methods  OCT was used to measure the eyes of 460 healthy Japanese volunteers aged 20 to 84. One eye of each individual was selected for the statistical analysis. Results|The average circumpapillary (cp) RNFL thickness of all eyes was 111.8 ± 10.0 μm. A statistically significant negative correlation was found between the average cp RNFL thickness and age. For every decade increase in age, the average cp RNFL thickness decreased by approximately 2.2 μm. The average cp RNFL thickness was estimated to decrease ... (Read Full Article)
   

   Comment on Article Mentions:   Yamagata University   Makoto Kanno   MicroTomography Incorporated

9. In Vitro Angioplasty of Atherosclerotic Human Femoral Arteries: Analysis of the Geometrical Changes in the Individual Tissues Using MRI and Image Processing

   Explore Article SpringerLink Home (Feb 11 2010) Cardiology

   Existing atherosclerotic plaque imaging techniques such as intravascular ultrasound, multidetector computed tomography, optical coherence tomography, and high-resolution magnetic resonance imaging (hrMRI) require computerized methods to separate and analyze the plaque morphology. In this work, we perform in vitro balloon angioplasty experiments with 10 human femoral arteries using hrMRI and image processing. The vessel segments contain low-grade to high-grade lesions with very different plaque compositions. The experiments are designed to mimic the in vivo situation. We use a semi-automatic image processing tool to extract the three-dimensional (3D) geometries of the tissue components at four characteristic stages of the angioplasty procedure. The ... (Read Full Article)
   

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10. Carbonized blood deposited on fibres during 810, 940 and 1,470 nm endovenous laser ablation: thickness and absorption by optical coherence tomography

    Explore Article SpringerLink Home (Feb 10 2010) Cardiology

    Endovenous laser ablation (EVLA) is commonly used to treat saphenous varicosities. Very high temperatures at the laser fibre tip have been reported during EVLA. We hypothesized that the laser irradiation deposits a layer of strongly absorbing carbonized blood of very high temperature on the fibre tip. We sought to prove the existence of these layers and study their properties by optical transmission, optical coherence tomography (OCT) and microscopy. We analysed 23 EVLA fibres, 8 used at 810 nm, 7 at 940 nm and 8 at 1,470 nm. We measured the transmission of these fibres in two wavelength bands (450–950 nm; 950–1,650 nm). We used 1,310 nm ... (Read Full Article)
    

    Comment on Article Mentions:   Academic Medical Center at the University of Amsterdam   Thoraxcenter at Erasmus University Medical Center

11. Investigation of gold-coated bare fiber probe for in situ intra-vitreous coherence domain optical imaging and sensing

    Explore Article SpringerLink Home (Feb 9 2010) Ophthalmology , Probes

    Abstract  We have investigated the usage of gold-plated bare fiber probes for in situ imaging of retinal layers and surrounding ocular tissues using time-domain common-path optical coherence tomography. The fabricated intra-vitreous gold-plated micro-fiber probe can be fully integrated with surgical tools working in close proximity to the tissue to provide subsurface images having a self-contained reference plane independent to the Fresnel reflection between the distal end of the probe and the following medium for achieving reference in typical common-path optical coherence tomography. We have fully characterized the probe in an aqueous medium equivalent to the vitreous humor in the eye and ... (Read Full Article)
    

    Comment on Article Mentions:   Johns Hopkins University   Food and Drug Administration   Jin U. Kang

12. A preliminary longitudinal study of the retinal nerve fiber layer in progressive multiple sclerosis

    Explore Article SpringerLink Home (Feb 8 2010) Neurology

    Abstract  Thinning of the retinal nerve fiber layer (RNFL) of clinically unaffected eyes is seen in patients with multiple sclerosis (MS). It is uncertain when this thinning occurs, and whether ongoing RNFL loss can be measured over time with optical coherence tomography (OCT). Using time-domain OCT, we studied 34 patients with progressive MS (16 primary progressive MS, 18 secondary progressive; 14 male; 20 female; mean age at study entry 51 years; median EDSS 6; mean disease duration at study entry 12 years) on two occasions with a median interval of 575 (range 411–895) days apart. Eighteen healthy controls (10 male; eight female; mean ... (Read Full Article)
    

    Comment on Article Mentions:   University College London

13. Fourier Domain – Optical Coherence Tomography in Diagnosing and Monitoring of Retinal Diseases

    Explore Article SpringerLink Home (Feb 1 2010) Ophthalmology

    This paper presents some applications of spectral domain - optical coherence tomography in diagnosing and monitoring retinal diseases such as: central serous chorioretinopathy, age-related macular degeneration, epiretinal membrane with macular pseudohole and diabetic maculopathy. (Read Full Article)
    

    Comment on Article Mentions:   Topcon Medical Systems   Topcon 3D OCT-1000

14. Anterior segment optical coherence tomography of acute primary angle closure

    Explore Article SpringerLink Home (Feb 1 2010) Ophthalmology

    Background To assess anterior segment optical coherence tomographic measurements of patients after acute unilateral primary angle closure (APAC) compared with those of normal subjects. Methods The clinical observational study included 41 hospital-based patients after unilateral APAC, their unaffected contralateral eyes, and 205 subjects. These were selected from the population-based Beijing Eye Study, and were matched with the APAC group for age, gender, and refractive error. All study participants underwent slit-lamp adapted optical coherence tomography (OCT). Results Compared with the unaffected contralateral eyes, eyes with APAC had a significantly shallower anterior chamber (P < 0.001), smaller chamber angle (P < 0.001), shorter anterior chamber opening ... (Read Full Article)
    

    Comment on Article Mentions:   Capital Medical University   University of Heidelberg   Jost B. Jonas

15. Spectral-domain optical coherence tomography findings in idiopathic juxtafoveal retinal telangiectasis type 2a

    Explore Article SpringerLink Home (Jan 25 2010) Ophthalmology

    (Article in German) PURPOSE: To describe the spectral-domain optical coherence tomography (OCT) findings in a patient with idiopathic juxtafoveal retinal telangiectasis (IJRT) type 2A and correlate them with the fluorescein angiography (FA) signs. METHODS: Case report. PATIENT: A 59 years old male patient presented with slow decrease in vision and metamorphopsia, most prominent in his left eye. The ophthalmoscopic and FA examination set the diagnosis of IJRT type 2A nonproliferative stage 3 in the right eye and proliferative stage 5 in the left eye [2]. RESULTS: The spectral-domain OCT revealed thickness decrease and reflectivity attenuation of the outer layers, deep ... (Read Full Article)
    

    Comment on Article Mentions:   Susanne Binder   Ludwig Boltzmann Institute

16. Incision Quality in MICS from Minimizing Incisions and Maximizing Outcomes in Cataract Surgery

    Explore Article SpringerLink Home (Jan 13 2010) Ophthalmology

    Core Messages • Minimization of the incision is a consequence of a natural evolution of the cataract surgery technique. • Good-quality incision is the cornerstone for the success of any type of cataract surgery. • Microincision cataract surgery (BMICS) provides not only a small incision size of 1.5 mm, but also an incision of good quality with minimal tissue damage. • Excellent incision quality in BMICS provides immediate, postoperative, unaided visual rehabilitation and early patient satisfaction. • One of the major advantages of BMICS is the reduction of surgical trauma resulting in a reduction of surgically induced astigmatism (SIA) and ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Visante OCT   Carl Zeiss Meditec

17. Evaluation of Blood-Retinal Barrier Function from Fourier Domain High-Definition Optical Coherence Tomography

    Explore Article SpringerLink Home (Jan 4 2010) Ophthalmology

    The aim of the work presented in this paper is to demonstrate the possibility of using a non-invasive imaging technique, the high-definition optical coherence tomography, as a surrogate detector of blood-retinal barrier breakdown. The retinal leakage analyzer is currently the only available technique to map the blood-retinal barrier function, a structure affected by diabetes, one of the most frequent cases in clinical practice.Nevertheless, it requires dedicated instrumentation and skilled personnel and is used only in the clinical research environment. Recently launched optical coherence devices, of the spectral or Fourier domain type, are able to scan the human retina at high ... (Read Full Article)
    

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18. Fourier Domain Mode Locking (FDML): Wavelength Swept Lasers for Ultrahigh Speed Optical Coherence Tomography

    Explore Article SpringerLink Home (Jan 4 2010) Tunable Sources

    Optical coherence tomography (OCT) is a novel, depth resolved biomedical imaging technique, providing highresolution, cross-sectional and three-dimensional images of tissue microstructure. The application of OCT systems based on rapidly wavelength swept, narrow band light sources, referred to as “swept source OCT” or “optical frequency domain imaging”, offers several potential advantages compared to high speed OCT systems based on fast spectrometers. The advent of Fourier domain mode locked (FDML) lasers as light sources for swept source OCT enabled high imaging speeds of up to 370.000 lines or A-scans per second, combined with good phase stability and long ranging depths. In this ... (Read Full Article)
    

    Comment on Article Mentions:   Ludwig Maximilians Universität München   Robert A. Huber

19. Dynamic Retinal Ultra-High Speed Optical Coherence Microscopy

    Explore Article SpringerLink Home (Jan 4 2010) Microscopy , Ophthalmology

    The trend in biomedical imaging is towards high resolution imaging of dynamic physiologic or metabolic processes. Fourier domain optical coherence tomography employing novel CMOS detector technology allows for a big step in this direction. Acquisition speeds of 200kHz reveal comprehensive tissue details on the level of histology but in-vivo due to virtual lack of motion artifacts. We applied this system to the retina and achieved high resolution imaging with 5μm × 3μm transverse and axial resolution. Such resolution allows observing microscopic details such as photoreceptor cone mosaic, nerve fiber bundles, and the capillary bed. Fast image series assess perfusion dynamics ... (Read Full Article)
    

    Comment on Article Mentions:   Rainer A. Leitgeb   Medical University of Vienna

20. Cervical Soft Tissue Motion Measurement by Optical Coherence Tomography

    Explore Article SpringerLink Home (Jan 1 2010) Gynecology , Oncology , Otolaryngology

    To design a semi-automatic laser scalpel for tissue resection in the area of neck masses it was necessary to examine the biomechanic behavour of these tissues. The aim was to identify if and to what extent (amplitude and velocity) the tissues shift due to respiration and circulation. This is important since these movements have to be followed by the laser scalpel. At defined points on the neck surface onedimensional (1-D) time related Optical Coherence Tomography OCT measurements were recorded. Tissue shifting in the direction of the OCT-sightaxis was quantified. The preliminary results of these basic experiments shown here will be ... (Read Full Article)
    

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21. A comparison of multifocal ERG and frequency domain OCT changes in patients with abnormalities of the retina

    Explore Article SpringerLink Home (Dec 30 2009) Ophthalmology

    To compare the ability of the multifocal electroretinogram (mfERG) and frequency domain optical coherence tomography (fdOCT) to detect retinal abnormalities. A total of 198 eyes (100 patients) were referred by neuro-ophthalmologists to rule out a retinal etiology of visual impairment. All patients were evaluated with static automated perimetry (SAP) (Humphrey Visual Field Analyzer; Zeiss Meditec), mfERG (Veris, EDI) and fdOCT (3D-OCT 1000, Topcon). The mfERG was performed with 103 scaled hexagons and procedures conforming to ISCEV standards (Hood DC et al. (2008) Doc Ophthalmol 116(1):1–11). The fdOCT imaging included horizontal and vertical line scans through the fovea. Local mfERG and ... (Read Full Article)
    

    Comment on Article Mentions:   Topcon Medical Systems   Topcon 3D OCT-1000   Columbia University

22. Correlation of retinal sensitivity with visual acuity and macular thickness in eyes with idiopathic epimacular membrane

    Explore Article SpringerLink Home (Dec 29 2009) Ophthalmology

    The aim of this study was to analyze macular function by measuring the sensitivity of the macula with fundus-related microperimetry and to compare the results with the best corrected visual acuity (BCVA) and foveal retinal thickness measured by optical coherence tomography (OCT) in patients with idiopathic epimacular membrane. We prospectively reviewed 66 eyes with idiopathic epimacular membrane and 35 normal healthy eyes in patients who had undergone fundus-related microperimetry and OCT. The macular sensitivity was measured using the recently introduced fundus-related microperimeter, MP-1. The mean retinal sensitivities in the central 10° (central microperimetry, cMP-1) and in the paracentral 10–20° (paracentral ... (Read Full Article)
    

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23. Optical coherence tomography imaging: current status and future perspectives

    Explore Article SpringerLink Home (Dec 25 2009) Cardiology

    Optical coherence tomography (OCT) is an optical analogue of intravascular ultrasound that provides high-resolution (10–20 μm) cross-sectional images of coronary arteries. The micron-scale resolution of OCT has an ability to capture in vivo what was previously seen only through a pathologist’s microscope. OCT can differentiate three types of atherosclerotic plaque components (fibrous, fibrocalcific and lipid-rich) with high sensitivity and specificity. Early in vitro and in vivo studies have demonstrated a possibility of OCT for identifying vulnerable plaque features, in particular the quantification of plaque rupture, intracoronary thrombus, thin-capped fibroatheroma and the distribution of macrophages within the fibrous cap. In addition, ... (Read Full Article)
    

    Comment on Article Mentions:   Takashi Kubo   Wakayama Medical University   Takashi Akasaka

24. Compression as a method for increasing the informativity of optical coherence tomography of biotissues

    Explore Article SpringerLink Home (Dec 24 2009)

    The efficiency of the mechanical compression of biotissues for improving the differentiation between pathological changes in the structure of a biotissue observed by the method of optical coherence tomography (OCT) is investigated. The effect of the compression in the OCT-images of samples of the human rectum affected by inflammation and carcinoma is studied ex vivo. It is shown that the use of compression makes it possible to differentiate between these pathological changes. To interpret experimental data, images of an inflamed part of rectum are modeled by the Monte Carlo method for different degrees of compression. The results of modeling agree ... (Read Full Article)
    

    Comment on Article Mentions:   Russian Academy of Sciences   Nizhny Novgorod State Medical Academy   Elena V. Zagaynova

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