1. Articles from jaad.org

  2. 1-13 of 13
    1. Imaging Technologies for Pre-surgical Margin Assessment of Basal Cell Carcinoma

      Imaging Technologies for Pre-surgical Margin Assessment of Basal Cell Carcinoma

      Basal cell carcinoma is the most common cancer worldwide, necessitating the development of techniques to decrease treatment costs through efficiency and efficacy. Mohs micrographic surgery, a specialized surgical technique involving staged resection of the tumor with complete histologic evaluation of the peripheral margins, is highly utilized. Reducing stages by even 5-10% would result in significant improvement in care and economic benefits. Non-invasive imaging could aid in both establishing the diagnosis of suspicious skin lesions and streamlining the surgical management of skin cancers by improving pre-surgical estimates of tumor size. Herein, we review the current state of imaging techniques in dermatology ...

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    2. Combined reflectance confocal microscopy and optical coherence tomography to improve the diagnosis of equivocal lesions for basal cell carcinoma

      Combined reflectance confocal microscopy and optical coherence tomography to improve the diagnosis of equivocal lesions for basal cell carcinoma

      To the Editor: Small-sized (<10 mm) basal cell carcinomas (BCC) lacking specific dermoscopic features are challenging to diagnose. Even with reflectance confocal microscopy (RCM), the specificity remains low (37.5%-75.5%) 1 due to limited imaging depth (200 μm), en face visualization, and a lack of melanin contrast for non/lightly pigmented lesions. 2 A novel combined handheld RCM and optical coherence tomography (OCT) device (RCM-OCT) has been developed to overcome these limitations. RCM-OCT provides real-time en face RCM and vertical OCT 3 images simultaneously and has been shown to be confirmatory of a BCC diagnosis 4 ; however, it ...

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    3. Presurgical evaluation of basal cell carcinoma using combined reflectance confocal microscopy-optical coherence tomography: A prospective study

      Presurgical evaluation of basal cell carcinoma using combined reflectance confocal microscopy-optical coherence tomography: A prospective study

      Background Initial biopsy of basal cell carcinoma (BCC) may fail to show aggressive histologic subtypes. Additionality, the clinical evaluation of BCC prior to surgery can miss subclinical extension. Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) are emerging tools that can help in the presurgical evaluation of BCCs. Objective To assess the feasibility of a combined RCM-OCT imaging modality for presurgical evaluation of biopsy-proven BCCs for residual tumor, margins-status, and depth. Methods Thirty-eight BCCs in 35 patients referred to a tertiary cancer center for Mohs micrographic surgery (MMS) were imaged using combined RCM-OCT. Images were correlated to MMS-frozen-sections. Results ...

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    4. Optical coherence tomography (OCT) features of nevi and melanomas and their association with intraepidermal or dermal involvement: A pilot study

      Optical coherence tomography (OCT) features of nevi and melanomas and their association with intraepidermal or dermal involvement: A pilot study

      To the Editor: Optical coherence tomography (OCT) was shown to be an useful tool for the fast evaluation of nonmelanocytic tumors of the skin. 1 There are few reports in the literature studying melanocytic lesions with OCT, with variable and sometimes contrasting results. 2 , 3 A constant need for reducing costs and cosmetic concerns of unnecessary excisions of suspicious melanocytic lesions lead us to further investigate this new technology. 4 We used OCT (Vivosight OCT Scanner, Michelson Diagnostics Ltd, Orpington, Kent, United Kingdom) to evaluate a total of 39 lesions: 19 melanomas (10 in situ and 9 invasive, with Breslow ...

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    5. Noninvasive monitoring of basal cell carcinomas treated with systemic hedgehog inhibitors: Pseudocysts as a sign of tumor regression

      Noninvasive monitoring of basal cell carcinomas treated with systemic hedgehog inhibitors: Pseudocysts as a sign of tumor regression

      Background Oral hedgehog inhibitors (HHIs) have shown significant efficacy in the treatment of basal cell carcinoma (BCC). The evaluation of tumor regression has been performed using clinical photography and radiographic scans. Noninvasive imaging techniques, such as reflectance confocal microscopy (RCM) and high-definition optical coherence tomography (HD-OCT), have been shown to be valuable in detecting BCC in the skin. Objective We monitored HHI-treated BCC using RCM and HD-OCT in vivo and correlated morphologic changes seen on imaging to changes in traditional histopathology. Methods Six BCCs in 5 patients receiving HHIs (vismodegib or sonidegib) were examined by RCM and HD-OCT before and ...

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    6. Confocal laser scanning microscopy and optical coherence tomography for the evaluation of the kinetics and quantification of wound healing after fractional laser therapy

      Confocal laser scanning microscopy and optical coherence tomography for the evaluation of the kinetics and quantification of wound healing after fractional laser therapy

      Background Information on the course of wound healing after fractional carbon-dioxide laser therapy has so far been gathered by histopathology. Confocal laser scanning microscopy (CLSM) and optical coherence tomography (OCT) allow the visualization of the upper layers of the skin in vivo over time. Objective The aim of this study was to determine whether CLSM and OCT can be used to quantify the kinetics of the dynamic wound-healing process. Methods Twenty healthy probands were treated with fractional carbon-dioxide laser with 8- and 16-W laser power, respectively. Optical follow-ups using CLSM and OCT were performed right after laser application and during ...

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    1-13 of 13
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