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    1. Quantitative OCT angiography of the retinal and choroidal vascular circulation in pediatric patients with neurofibromatosis type 1

      Quantitative OCT angiography of the retinal and choroidal vascular circulation in pediatric patients with neurofibromatosis type 1

      Purpose To investigate retinal and choroidal microvascular changes in neurofibromatosis type 1 (NF1) pediatric patients using optical coherence tomography angiography (OCTA). Methods This study was performed on 21 eyes of 21 NF1 patients and 30 eyes of 30 healthy subjects. Foveal avascular zone (FAZ) parameters, including area, perimeter, acircularity index, and foveal density, were measured using OCTA. Superficial (SCP) and deep (DCP) capillary plexus and radial peripapillary capillary (RPC) vessel densities and choriocapillaris flow were also evaluated. Choroidal nodules and thickness were detected using infrared reflectance and enhanced-depth imaging OCT. Results No significant differences were observed for FAZ parameters or ...

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    2. Analysis of optical coherence tomography angiographic findings of prematurely born children and its relationship with macular edema of prematurity

      Analysis of optical coherence tomography angiographic findings of prematurely born children and its relationship with macular edema of prematurity

      Purpose To compare foveal avascular zone (FAZ) area, foveal vascular density (VD), and foveal thickness in pre- and full-term children and to evaluate their relationship with cystoid macular edema (CME) in the prematurity period using spectral domain optical coherence tomography angiography (SD-OCTA). Methods OCTA imaging was performed at 4-6 years of age in 90 eyes of 45 prematurely born children and 50 eyes of 25 term children. Subjects were divided into three groups: prematurely born with CME (group 1); prematurely born without CME (group 2); healthy, term children (group 3). Imaging results in the three groups were compared. Results FAZ ...

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    3. Evaluation of macular vessel density changes after strabismus surgery using optical coherence tomography angiography

      Evaluation of macular vessel density changes after strabismus surgery using optical coherence tomography angiography

      Purpose To compare retinal vessel density before and after strabismus surgery using swept-source optical coherence tomography angiography (SS-OCTA). Methods In this longitudinal, single-arm pilot study, vascular density in the deep capillary plexus (DCP), superficial retinal capillary plexus (SCP) and choriocapillaris layer (CCL) in consecutive subjects undergoing strabismus surgery was assessed using SS-OCTA preoperatively (T0), on the first day postoperatively (POD1), and 30 days postoperatively (POD30). Results A total of 92 eyes of 56 patients (54% males) were included. Mean patient age was 41.1 ± 22.7. OCT vascular density of the DCP was 50.20 ± 5.57 at T0, 52 ...

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    4. Optical coherence tomography angiography findings of retinal vascular structures in children with celiac disease

      Optical coherence tomography angiography findings of retinal vascular structures in children with celiac disease

      Purpose To investigate the vasculature of the retina and choroid in children with celiac disease using optical coherence tomography angiography (OCTA). Methods A total of 60 children with celiac disease and 71 healthy controls were included in this study. All participants underwent comprehensive ophthalmologic examination and OCTA imaging. The vascular structures and the vascular density (VD) in the superficial and deep retinal vascular zones, the foveal avascular zone (FAZ) and foveal density were automatically determined using the software 3 × 3 OCTA and AngioAnalytics. Choroid thickness was calculated manually by retinal specialists. Results No statistically significant difference in VD was found ...

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    5. Optical coherence tomography angiography of subclinical ocular features in pediatric Behçet disease

      Optical coherence tomography angiography of subclinical ocular features in pediatric Behçet disease

      Purpose To investigate macular and optic nerve head (ONH) vascular density (VD), foveal avascular zone (FAZ) area, choroidal thickness, outer retina and choriocapillaris flow, and morphological changes of foveal microvasculature in pediatric Behçet disease (BD) without ocular involvement using optical coherence tomography angiography (OCTA). Methods We analyzed 22 eyes of 22 pediatric patients diagnosed with BD without ocular involvement and 24 age- and sex-matched healthy controls in this prospective, cross-sectional study. The superficial capillary plexus (SCP) and the deep capillary plexus (DCP), FAZ parameters, the flow area of the outer retina, and choriocapillaris were evaluated using OCTA. Results Vessel ...

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    6. Vitreous opacities in infants born full-term and preterm by handheld swept-source optical coherence tomography

      Vitreous opacities in infants born full-term and preterm by handheld swept-source optical coherence tomography

      Purpose To compare vitreous opacity density in infants born at term and in infants born prematurely using an investigational handheld swept-source optical coherence tomography (SS-OCT). Methods Infants born at term underwent imaging once between 12 and 48 hours after birth; infants born prematurely were imaged at each routine retinopathy of prematurity (ROP) examination. Three masked, trained graders analyzed images. Semiautomated methods were used to quantify vitreous opacity density, which was correlated with ROP severity based on indirect ophthalmoscopy, other SS-OCT findings, and medical comorbidities. Results Between April 2018 and June 2019, 251 SS-OCT imaging sessions were performed on 78 infants ...

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    7. Retinal and peripapillary vessel density increase in recovered COVID-19 children by optical coherence tomography angiography

      Retinal and peripapillary vessel density increase in recovered COVID-19 children by optical coherence tomography angiography

      Purpose To evaluate retinal vascular changes in children who have recovered from coronavirus disease (COVID-19) using optical coherence tomography angiography (OCTA) and to compare the results with age-matched healthy children. Methods In this cross-sectional case–control study, children 6-18 years of age with laboratory-confirmed SARS-CoV-2 infection were compared with historic healthy controls. All participants underwent ophthalmological examination, including fundus photography and OCTA of the macular region and optic disk. COVID-19 children were examined 4-8 weeks after COVID-19 diagnoses. Demographic data, medical history, and COVID-19 symptoms were noted. OCTA parameters in the superficial capillary plexus (SCP) were analyzed according to ETDRS ...

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    8. Comparison of quantitative measurement of macular vessel density before and after inferior oblique muscle–weakening surgery: an optical coherence tomography angiography study

      Comparison of quantitative measurement of macular vessel density before and after inferior oblique muscle–weakening surgery: an optical coherence tomography angiography study

      Purpose To investigate hemodynamic changes in retinal and choroidal vasculature after surgical inferior oblique (IO) weakening through optical coherence tomography angiography (OCTA). Methods The medical records of patients who underwent unilateral IO-weakening surgery at a single institution were retrospectively reviewed. Patients who had OCTA measurements before surgery and on postoperative days 7 and 30 were included. Vessel density was determined for the superficial capillary plexus (SCP), deep capillary plexus (DCP), the choriocapillaris (CCP) and the foveal avascular zone (FAZ). Results The study included 72 eyes of 36 patients. Fellow eyes were used as a control group. The preoperative and postoperative ...

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    9. Best practice patterns: how to effectively use OCT in pediatric ophthalmology

      Best practice patterns: how to effectively use OCT in pediatric ophthalmology

      As optical coherence tomography (OCT) technology has advanced, and become more widely available, it is being used more commonly in pediatric ophthalmology. As the technology demonstrates value as an integral part of the evaluation of the pediatric eye, it is critical for pediatric ophthalmologists to understand how to incorporate OCT into their clinical flow, interpret results, and make clinical decisions based on OCT findings. The purpose of this workshop is to review basic OCT interpretation and discuss recent advances in OCT technology, including OCT angiography. We will discuss the pearls and pitfalls in utilizing OCT in the evaluation and management ...

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    10. Comparison of the swept-source anterior segment optical coherence tomography and wide-field ultrasound biomicroscopy for imaging previously operated horizontal extraocular muscles

      Comparison of the swept-source anterior segment optical coherence tomography and wide-field ultrasound biomicroscopy for imaging previously operated horizontal extraocular muscles

      Purpose To assess the feasibility and accuracy of determining extraocular muscle insertion distance from the limbus of previously operated extraocular muscles with the swept-source anterior segment optical coherence tomography (AS-OCT) compared with wide-field ultrasound biomicroscope (UBM). Methods Patients with a history of previous strabismus surgery for whom additional strabismus surgery was planned were enrolled. The insertion distance was measured by AS-OCT and UBM before reoperation and compared to the caliper measurement at the time of surgery. Observers taking measurements were masked to patient data. Patient comfort for both machines was graded on a scale of 1-10 and timing of both ...

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    11. Dome-shaped macula in premature infants visualized by handheld spectral-domain optical coherence tomography

      Dome-shaped macula in premature infants visualized by handheld spectral-domain optical coherence tomography

      Purpose To describe dome-shaped macula and associated clinical findings in premature infants. Methods This prospective, observational cohort study included a consecutive sample of premature infants screened for retinopathy of prematurity (ROP) with 9-month follow-up. Handheld spectral domain optical coherence tomography (SD-OCT) was performed at the time of ROP screening. Images were assessed for dome-shaped macula, cystoid macular edema, epiretinal membrane, vitreous bands, and punctate hyperreflective vitreous opacities. Dome height measurements were performed in a subset of images. Teller visual acuity and cycloplegic refraction were performed at an adjusted age of 8-10 months. Results Of 37 infants (74 eyes; 49% male ...

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    12. Optical coherence tomography imaging of the pediatric retina

      Optical coherence tomography is an increasingly important part of the retinal specialist’s and general ophthalmologist’s toolkit for diagnosing and managing retinal disease. This review summarizes the unique considerations and available imaging systems with which pediatric ophthalmologists should be familiar when attempting optical coherence tomography in children.

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    13. Aphakic contact lens use for improved handheld optical coherence tomography imaging in pediatric aphakic patients

      Aphakic contact lens use for improved handheld optical coherence tomography imaging in pediatric aphakic patients

      Handheld optical coherence tomography (OCT) makes it possible to acquire intraoperative and clinical imaging in infants and children for whom standard OCT is not possible. In patients with a retinal pathology who are left aphakic after surgery, however, image clarity is affected by insufficient refractive correction with handheld OCT. We describe a technique for supplementing the refractive power of the handheld OCT device with an aphakic contact lens to improve image clarity.

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      Mentions: Duke University
    14. Subclinical retinal microvascular alterations assessed by optical coherence tomography angiography in children with systemic hypertension

      Subclinical retinal microvascular alterations assessed by optical coherence tomography angiography in children with systemic hypertension

      Purpose To compare the foveal avascular zone (FAZ) macular and peripapillary vessel density between children with high blood pressure and healthy subjects. Methods A total of 40 eyes of 20 children with hypertension and 40 eyes of 20 age- and sex-matched healthy controls were included. Capillary vessel density (CVD) in superficial (SCP) and deep (DCP) retinal capillary plexus, peripapillary region, and FAZ were analyzed by optical coherence tomography angiography. Results The mean ages were 15.2 ± 1.5 years (range, 10-18) in patients with hypertension and 14.4 ± 2.8 years (range, 10-18) in healthy controls ( P = 0.742). The ...

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    15. Myopia and anterior segment optical coherence tomography findings in laser-treated retinopathy of prematurity eyes

      Myopia and anterior segment optical coherence tomography findings in laser-treated retinopathy of prematurity eyes

      Purpose To evaluate structural features and visual outcomes in eyes with a prior history of laser treatment for retinopathy of prematurity (ROP). Methods Laser-treated eyes for type 1 ROP, preterm monitored eyes, and full-term control eyes were included. LogMAR conversion of Snellen best-corrected visual acuity and spherical equivalent based on cycloplegic refraction were measured in children 5-15 years of age. Anterior segment optical coherence tomography (OCT) was used to study structural features, including anterior chamber angle (ACA) in a subset of eyes. Results A total of 50 eyes of 50 patients were included (19 full-term eyes, 19 laser-treated type 1 ...

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    16. Nystagmus and optical coherence tomography findings in CNGB3-associated achromatopsia

      Nystagmus and optical coherence tomography findings in CNGB3-associated achromatopsia

      Purpose To describe the nystagmus characteristics of subjects with molecularly confirmed CNGB3 -associated achromatopsia and report the spectral domain optical coherence tomography (SD-OCT) findings in these individuals. Methods Adults and children with CNGB3 -achromatopsia underwent visual acuity testing, ocular motility assessments, video nystagmography, and SD-OCT imaging. Qualitative assessment of foveal structure was performed by grading SD-OCT images into one of five categories. Results A total of 18 subjects (11 adults) were included. The majority demonstrated a phoria, with manifest strabismus present in only 3 subjects. The predominant nystagmus waveform within the cohort was pure pendular. Nine individuals demonstrated a mixture ...

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    17. Differences of megalopapilla and normal sized disk with age—an optical coherence tomography analysis

      Differences of megalopapilla and normal sized disk with age—an optical coherence tomography analysis

      Purpose To compare the optic disks of children and adults with megalopapilla using optical coherence tomography (OCT). Subjects and Methods: We conducted a case–control study of subjects with megalopapilla and normal sized disks seen between February 2013 and July 2015 at the Hospital da Luz, Lisbon. All subjects and controls were imaged with spectral domain OCT, and optic nerve head (ONH) parameters were evaluated. The main outcome measures were rim area, cup:disk ratio, and cup volume. Results A total of 168 eyes of 168 subjects were included: 78 with megalopapilla (39 children / 39 adults) and 90 (45/45 ...

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    18. Longitudinal reproducibility of spectral domain optical coherence tomography in children with physiologic cupping and stable glaucoma

      Longitudinal reproducibility of spectral domain optical coherence tomography in children with physiologic cupping and stable glaucoma

      Purpose To determine whether Spectralis (Heidelberg, Germany) spectral domain optical coherence tomography (SD-OCT) measurements are reproducible over time in children with physiologic cupping and stable glaucoma. Methods Subjects were identified from a subset of participants in an earlier retrospective study conducted by our group and included children (<18 years of age) with physiologic cupping and stable primary congenital glaucoma (PCG) having had at least 2 SD-OCTs over a period of more than 1 between April 2010 and September 2015. Thicknesses of average peripapillary retinal nerve fiber layer (pRNFL) and six individual sectors and volumes of three segmented retinal layers and ...

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    19. Quantitative analysis of retinal microcirculation in children with hyperopic anisometropic amblyopia: an optical coherence tomography angiography study

      Quantitative analysis of retinal microcirculation in children with hyperopic anisometropic amblyopia: an optical coherence tomography angiography study

      Purpose To evaluate optical coherence tomographic angiography (OCTA) findings on retinal microcirculation in hyperopic anisometropic amblyopia compared with fellow eyes and nonamblyopic control eyes. Methods A total of 40 pediatric patients with hyperopic anisometropic amblyopia and 57 control subjects were recruited, and 137 eyes (40 amblyopic, 40 fellow, and 57 control eyes) were evaluated. Data on best-corrected visual acuity (logMAR), axial length (mm), refractive error, and OCTA findings (foveal avascular zone parameters, macular vascular density in superficial and deep retinal capillary plexus, central macular thickness) were recorded in amblyopic, fellow, and control eyes. Results Compared with fellow and control eyes ...

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    20. Microvascular changes in amblyopic eyes detected by optical coherence tomography angiography

      Microvascular changes in amblyopic eyes detected by optical coherence tomography angiography

      Purpose To investigate retinal microvascular findings detected by optical coherence tomography angiography (OCT-A) in amblyopic eyes compared with normal eyes. Methods A total of 23 amblyopic (strabismic, ametropic, anisometropic, and meridional amblyopia) and 22 normal eyes were included in this prospective observational, comparative study. All patients underwent complete ophthalmological examination and OCT-A imaging. Vessel density (VD) percentage in the superficial and deep retinal vessel plexus, foveal avascular zone (FAZ) area, flow area in the outer retina and choriocapillaris, and retinal thickness in μm in a 6.00 × 6.00 mm scan size were measured and compared between groups. Results There ...

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    21. Microvascular changes in amblyopic eyes detected by optical coherence tomography angiography

      Microvascular changes in amblyopic eyes detected by optical coherence tomography angiography

      T Purpose To investigate retinal microvascular findings detected by optical coherence tomography angiography (OCT-A) in amblyopic eyes compared with normal eyes. Methods A total of 23 amblyopic (strabismic, ametropic, anisometropic, and meridional amblyopia) and 22 normal eyes were included in this prospective observational, comparative study. All patients underwent complete ophthalmological examination and OCT-A imaging. Vessel density (VD) percentage in the superficial and deep retinal vessel plexus, foveal avascular zone (FAZ) area, flow area in the outer retina and choriocapillaris, and retinal thickness in μm in a 6.00 × 6.00 mm scan size were measured and compared between groups. Results ...

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    1-24 of 55 1 2 3 »
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