1. 1-24 of 34 1 2 »
    1. Quantitative analysis of retinal microcirculation in children with hyperopic anisometropic amblyopia: an optical coherence tomography angiography study

      Quantitative analysis of retinal microcirculation in children with hyperopic anisometropic amblyopia: an optical coherence tomography angiography study

      Purpose To evaluate optical coherence tomographic angiography (OCTA) findings on retinal microcirculation in hyperopic anisometropic amblyopia compared with fellow eyes and nonamblyopic control eyes. Methods A total of 40 pediatric patients with hyperopic anisometropic amblyopia and 57 control subjects were recruited, and 137 eyes (40 amblyopic, 40 fellow, and 57 control eyes) were evaluated. Data on best-corrected visual acuity (logMAR), axial length (mm), refractive error, and OCTA findings (foveal avascular zone parameters, macular vascular density in superficial and deep retinal capillary plexus, central macular thickness) were recorded in amblyopic, fellow, and control eyes. Results Compared with fellow and control eyes ...

      Read Full Article
    2. Microvascular changes in amblyopic eyes detected by optical coherence tomography angiography

      Microvascular changes in amblyopic eyes detected by optical coherence tomography angiography

      Purpose To investigate retinal microvascular findings detected by optical coherence tomography angiography (OCT-A) in amblyopic eyes compared with normal eyes. Methods A total of 23 amblyopic (strabismic, ametropic, anisometropic, and meridional amblyopia) and 22 normal eyes were included in this prospective observational, comparative study. All patients underwent complete ophthalmological examination and OCT-A imaging. Vessel density (VD) percentage in the superficial and deep retinal vessel plexus, foveal avascular zone (FAZ) area, flow area in the outer retina and choriocapillaris, and retinal thickness in μm in a 6.00 × 6.00 mm scan size were measured and compared between groups. Results There ...

      Read Full Article
    3. Microvascular changes in amblyopic eyes detected by optical coherence tomography angiography

      Microvascular changes in amblyopic eyes detected by optical coherence tomography angiography

      T Purpose To investigate retinal microvascular findings detected by optical coherence tomography angiography (OCT-A) in amblyopic eyes compared with normal eyes. Methods A total of 23 amblyopic (strabismic, ametropic, anisometropic, and meridional amblyopia) and 22 normal eyes were included in this prospective observational, comparative study. All patients underwent complete ophthalmological examination and OCT-A imaging. Vessel density (VD) percentage in the superficial and deep retinal vessel plexus, foveal avascular zone (FAZ) area, flow area in the outer retina and choriocapillaris, and retinal thickness in μm in a 6.00 × 6.00 mm scan size were measured and compared between groups. Results ...

      Read Full Article
    4. Differences in retinal nerve fiber layer thickness measured by spectral domain optical coherence tomography between primary congenital glaucoma patients and healthy children

      Differences in retinal nerve fiber layer thickness measured by spectral domain optical coherence tomography between primary congenital glaucoma patients and healthy children

      Purpose To evaluate the retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) in a population of children diagnosed with primary congenital glaucoma (PCG). Methods Cross-sectional study where 59 eyes from 59 children diagnosed with PCG and 87 eyes from 87 healthy children were evaluated by SD-OCT to measure the RNFL. The global average peripapillary RNFL thickness and sectional RNFL thickness were evaluated in both groups. Differences in global average and sectional thickness were analysed. Results Mean age in PCG group was 9.61±3.23 years old and in control groups was 8.47±2 ...

      Read Full Article
    5. Evaluation of retinal structure in unilateral amblyopia using spectral domain optical coherence tomography

      Evaluation of retinal structure in unilateral amblyopia using spectral domain optical coherence tomography

      Purpose To investigate potential differences in the retinal nerve fiber layer (RNFL) thickness, macular thickness and foveal thickness between amblyopic eyes and normal fellow eyes on spectral domain optical coherence tomography (SD-OCT). Methods A cross-sectional study of patients ≥10 years of age with unilateral amblyopia resulting from an anisometropic, strabismic or deprivative cause. Comprehensive ophthalmic examination was completed and the retinal structures of both eyes were measured using SD-OCT. We compared the measurements obtained between the amblyopic eye and the fellow normal eye in each subject. Results Twenty-six unilateral amblyopia patients with a mean age of 29.92 ± 14.19 ...

      Read Full Article
    6. OCT angiography findings in children with amblyopia

      OCT angiography findings in children with amblyopia

      Purpose To compare the microstructure and vascularity of amblyopic eyes in children with their contralateral eye and with eyes from control children using optical coherence tomography angiography (OCT-A). Methods We conducted a prospective, cross-sectional evaluation of macular and optic disk vascular density and flow area using OCT-A (Avanti RTVue XR, Optovue Inc, Fremont, CA). Parameters were calculated using automated software. Results A total of 52 children were included: 26 subjects with amblyopia and 26 nonamblyopic controls. The amblyopic eye of subjects showed a statistically significant decrease in macular vascular density ( P = 0.0171) of the superficial capillary plexus (SCP), in ...

      Read Full Article
    7. Bruch’s membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema

      Bruch’s membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema

      Purpose To determine whether the diameter of Bruch’s membrane opening (BMO) can distinguish mild papilledema from pseudopapilledema using optical coherence tomography (OCT). Methods The medical records of pediatric patients with pseudopapilledma due to optic nerve head (ONH) drusen, patients with papilledema, and normal control subjects were reviewed retrospectively. All eyes underwent OCT imaging of the BMO and retinal nerve fiber layer (RNFL). Transverse horizontal diameter of the BMO and papillary height were measured. Mean BMO, papillary height, and RNFL were compared and receiver operating characteristic (ROC) curves were used to calculate the area under the curve (AUC) and determine ...

      Read Full Article
    8. Comparison of quantitative measurement of foveal avascular zone and macular vessel density in eyes of children with amblyopia and healthy controls: an optical coherence tomography angiography study

      Comparison of quantitative measurement of foveal avascular zone and macular vessel density in eyes of children with amblyopia and healthy controls: an optical coherence tomography angiography study

      Purpose To quantify vessel density of superficial capillary plexus (SCP), deep capillary plexus (DCP), and the foveal avascular zone (FAZ) of children’s amblyopic eyes and to compare the measurements with those of companion eyes and age-matched controls. Methods Fifteen patients with strabismic amblyopia, and 15 age-matched controls were included in this cross-sectional study. SCP, DCP, and FAZ were measured via optical coherence tomographic angiography (OCTA). Results Mean subject age was 8.2 ± 2.3 years in the amblyopia group and 8.6 ± 2.2 years in the control group. The mean SCP at 1 mm, 2 mm, and 3 ...

      Read Full Article
    9. Spectral domain optical coherence tomography to assess the insertion of extraocular rectus muscles

      Spectral domain optical coherence tomography to assess the insertion of extraocular rectus muscles

      Purpose To determine the distance of the horizontal rectus muscle insertion to the limbus using spectral domain optical coherence tomography (SD-OCT) and to evaluate whether results are correlated with sex, age, or axial length. Methods The right eyes of healthy, white subjects were imaged with SD-OCT. Subjects’ sex and age were recorded, and axial length was measured using an optical biometer. The distance from the horizontal rectus insertion to the limbus was measured. The intraclass correlation coefficient (ICC) was used to assess the reproducibility of the measurements with a subset of images. A multivariate model was adjusted to analyze whether ...

      Read Full Article
    10. Optical coherence tomography to monitor vigabatrin toxicity in children

      Optical coherence tomography to monitor vigabatrin toxicity in children

      Purpose The antiepileptic drug vigabatrin is known to cause permanent loss of vision. Both visual field testing and electroretinogram are used to detect retinal damage. Adult data on optical coherence tomography (OCT) shows that retinal nerve fiber layer (RNFL) thinning may be an early indicator of vigabatrin-induced retinal toxicity. The purpose of this study was to investigate whether OCT can detect early vigabatrin-induced retinal toxicity in children. Methods Pediatric patients (≤18 years of age) requiring vigabatrin for seizure control who were followed at our institution were invited to participate. Patients were examined according to manufacturer guidelines, with most examinations taking ...

      Read Full Article
    11. Noninvasive assessment of the retina and the choroid using enhanced-depth imaging optical coherence tomography shows microvascular impairments in childhood obesity

      Noninvasive assessment of the retina and the choroid using enhanced-depth imaging optical coherence tomography shows microvascular impairments in childhood obesity

      Purpose To evaluate the retinal vascular diameters and macular and subfoveal choroidal thicknesses of obese and nonobese children using enhanced-depth imaging spectral domain optical coherence tomography (EDI SD-OCT). Methods The retinal vascular diameters of the 4 largest retinal arterioles and venules and macular and subfoveal choroidal thickness measurements of 40 obese children (body mass index [BMI] z score above +2.0 standard deviations) were obtained by EDI SD-OCT and compared with those of 40 age- and sex-matched nonobese children. Anthropometric measures, including weight and height, were also obtained. BMI z score was defined using standardized protocols. Results The mean BMI ...

      Read Full Article
    12. The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography segmentation

      The macula in pediatric glaucoma: quantifying the inner and outer layers via optical coherence tomography segmentation

      Recent Spectralis (Heidelberg, Germany) spectral domain optical coherence tomography research software can quantify the thickness of each individual retinal layer. There is a suggestion that the macular ganglion cell layer (GCL) and ganglion cell complex may be more sensitive for detecting glaucoma than the peripapillary retinal nerve fiber layer (pRNFL). The purpose of this study was to characterize/compare the thickness of each macular layer among children with glaucoma versus normals.

      Read Full Article
    13. Pediatric spectral domain optical coherence tomography (SD-OCT) normative data for novel optic nerve parameters using the Heidelberg Spectralis

      Pediatric spectral domain optical coherence tomography (SD-OCT) normative data for novel optic nerve parameters using the Heidelberg Spectralis

      SD-OCT normative data for optic nerve volume (ONV) and the peripapillary papillomacular bundle thickness have not been reported, yet these parameters are relevant for neuro-ophthalmic disease. The purpose of this study was to determine pediatric norms for these parameters and expand the dataset for typical OCT parameters.

      Read Full Article
    14. Reproducibility of retinal nerve fiber layer thickness measures using eye-tracking with spectral-domain optical coherence tomography in children with optic neuropathy

      Reproducibility of retinal nerve fiber layer thickness measures using eye-tracking with spectral-domain optical coherence tomography in children with optic neuropathy

      To determine the intra- and intervisit reproducibility of circumpapillary retinal nerve fiber layer (RNFL) thickness measures using eye-tracking-assisted spectral domain optical coherence tomography (SD-OCT) in children with nonglaucomatous optic neuropathy.

      Read Full Article
    15. Foveal microanatomy documented by SD-OCT following treatment of advanced retinoblastoma

      Foveal microanatomy documented by SD-OCT following treatment of advanced retinoblastoma

      Progress in the treatment of retinoblastoma has greatly improved patient survival and globe salvage rates. The introduction of intraoperative spectral domain optical coherence tomography (OCT) allows visualization of foveal anatomy and microstructure to predict visual potential and facilitate planning for visual rehabilitation. Eyes with total retinal detachments secondary to exophytic retinoblastoma have OCT findings of absence or disruption of the external limiting membrane and ellipsoid layers. We document the evolution of foveal microanatomy reconstitution following the use of chemotherapy in a 1-year-old boy and illustrate the restoration of the external limiting membrane and ellipsoid layer, thus achieving normal foveal microanatomy.

      Read Full Article
    16. The accuracy of anterior segment optical coherence tomography (AS-OCT) in localizing extraocular rectus muscles insertions

      The accuracy of anterior segment optical coherence tomography (AS-OCT) in localizing extraocular rectus muscles insertions

      Purpose To evaluate the accuracy of the anterior segment optical coherence tomography (AS-OCT) in measuring the distance from the limbus to the insertion of primary and previously operated rectus muscles in children. Methods In this prospective, double masked, observational study the distance of the extraocular muscle insertion from the limbus measured by AS-OCT preoperatively was compared to intraoperative measurement using the surgical calipers. Consecutive patients 4-18 years of age undergoing primary or repeat strabismus surgery on horizontal or vertical rectus muscles between September 2013 and May 2014 were included. Patients with any condition that interfered with imaging were excluded. Participants ...

      Read Full Article
    1-24 of 34 1 2 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks