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    1. Assessment of Anatomical and Functional Macular Changes with Optical Coherence Tomography Angiography After Macula-Off Rhegmatogenous Retinal Detachment Repair

      Assessment of Anatomical and Functional Macular Changes with Optical Coherence Tomography Angiography After Macula-Off Rhegmatogenous Retinal Detachment Repair

      Purpose: To evaluate macular capillary plexus changes with OCT-angiography with regard to macular detachment duration in macula-off rhegmatogenous retinal detachment (RRD). Methods : 23 eyes of 23 patients were included in this retrospective case-control study and were divided into 2 groups. Group-A had a macular detachment duration of 0 to 10 days and group-B of 11 to 30 days. All eyes underwent a single successful pars plana vitrectomy (PPV) and gas tamponade. We analysed the OCT-A characteristics and visual outcomes at 12 weeks postoperatively in the 2 groups. The fellow eye was used as control. Results: Vessel density (VD) and flow ...

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    2. Retinal nerve fibre layer and peripapillary vascular density by optical coherence tomography angiography in schizophrenia

      Retinal nerve fibre layer and peripapillary vascular density by optical coherence tomography angiography in schizophrenia

      Clinical relevance : Schizophrenia is a progressive disease. Analysis of retinal nerve fibre layer and peripapillary vascular density by optical coherence tomography angiography in schizophrenia patients may help to explain the pathophysiology of the disease. Background : Both macular and optic nerve microvascular structures can be visualised with optical coherence tomography angiography. Few studies have evaluated retinal vessels in patients with schizophrenia. Some of these studies suggest that larger retinal venules are associated with the severity of psychotic symptoms. Methods : This study evaluated retinal nerve fibre layer thickness and peripapillary vascular density by optical coherence tomography angiography in 22 eyes of 22 ...

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    3. Long-term progression of myopic maculopathy in degenerative myopia as imaged by SD-OCT and IR imaging

      Long-term progression of myopic maculopathy in degenerative myopia as imaged by SD-OCT and IR imaging

      Clinical relevance Clinicians can benefit from developing an understanding of the natural disease progression of myopic maculopathy in degenerative myopia using optical coherence tomography (OCT). Background The prevalence of high myopia is constantly increasing. In this work, infrared imaging and OCT is used to study the natural course of the disease. Methods This is a retrospective longitudinal study. Medical records of 72 patients with high myopia (< 6.00 D) and a minimum five-year follow-up period were analysed. Collected data on all enrolled patients included demographic characteristics and medical history, as well as recordings on best-corrected visual acuity, slitlamp examination, OCT ...

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    4. Recent progress of nondestructive techniques for fruits damage inspection: a review

      Recent progress of nondestructive techniques for fruits damage inspection: a review

      In the process of growing, harvesting, and storage, fruits are vulnerable to mechanical damage , microbial infections, and other types of damage , which not only reduce the quality of fruits , increase the risk of fungal infections, in turn greatly affect food safety, but also sharply reduce economic benefits. Hence, it is essential to identify damaged fruits in time. Rapid and nondestructive detection of fruits damage is in great demand. In this paper, the latest research progresses on the detection of fruits damage by nondestructive techniques , including visible/near-infrared spectroscopy, chlorophyll fluorescence techniques , computer vision, multispectral and hyperspectral imaging, structured-illumination reflectance imaging ...

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    5. Investigation of Retinal Vascular Changes during Pregnancy Using Optical Coherence Tomography Angiography

      Investigation of Retinal Vascular Changes during Pregnancy Using Optical Coherence Tomography Angiography

      Purpose : To investigate retinal vascular changes in pregnant women using optical coherence tomography angiography (OCTA). Materials and Methods : This prospective, cross-sectional study included 97 pregnant women and age-matched 34 healthy control subjects. The OCTA parameters of one eye (left) of pregnancy group and control group were compared. Besides, the OCTA parameters of three trimesters were compared between themselves and the control group. The foveal avascular zone (FAZ) area and the vessel density percentages of the superficial capillary plexus (SCP), deep capillary plexus (DCP), and radial peripapillary capillary (RPC) of all the groups were evaluated by OCTA. Results : In the pregnancy ...

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    6. Optical Coherence Tomography findings in patients with Multiple Substance Use Disorder

      Optical Coherence Tomography findings in patients with Multiple Substance Use Disorder

      Objective Optical Coherence Tomography (OCT) is a relatively new diagnosis method displaying biological tissue layers by with high-resolution sections. In the present study, the purpose was to examine the OCT findings of patients with Multiple Substance Use Disorder (MSUD) by comparing these findings with healthy controls. Methods The study included 30 MSUD and 30 controls. Detailed biomicroscopic examinations were carried out for all participants, and intraocular pressure, followed by OCT. The central macular thickness (CMT), mean macular thickness (MMT), mean macular volume (MMV), and retinal nerve fibre layer thickness (RNFL) were measured by using OCT. Results It was determined that ...

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    7. Ganglion cell and retinal nerve fiver layers correlated with time disease of bipolar disorder using 64 cell grid OCT tool

      Ganglion cell and retinal nerve fiver layers correlated with time disease of bipolar disorder using 64 cell grid OCT tool

      Purpose of the study: To assess the ability of the new Spectralis Optical Coherence Tomography (OCT) Posterior Pole protocol to detect degeneration of the inner retinal layers in patients with bipolar disorder (BD) and to assess the correlation between the neuroretinal thickness and disease duration. Materials and methods: Twenty-five eyes of 25 patients with bipolar disorder and 74 eyes of 74 healthy controls underwent retinal measurements of retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness. Measurements were obtained using the Spectralis-OCT device with the new Posterior Pole protocol which assesses the macular area by analyzing retinal thickness ...

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    8. Evaluation of ocular hypoperfusion in patients with acromegaly by using optical coherence tomography angiography

      Evaluation of ocular hypoperfusion in patients with acromegaly by using optical coherence tomography angiography

      Purpose: This study aimed to evaluate the retinal blood vessel parameters and the foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) in patients with acromegaly in comparison with healthy controls. Methods: A total of 45 patients with acromegaly and 45 healthy controls were included in this study. In all patients, the vessel density (VD) of the deep and superficial macular vascular networks and the foveal avascular zone (FAZ) were measured using OCTA. The correlation of insulin-like growth factor 1 (IGF-1) level and disease duration with deep macular VD and FAZ values was analyzed. All parameters were registered ...

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    9. Retinal neurodegeneration in diabetic peripheral neuropathy by optical coherence tomography: a systematic review and meta-analysis

      Retinal neurodegeneration in diabetic peripheral neuropathy by optical coherence tomography: a systematic review and meta-analysis

      Purpose: The optical coherence tomography (OCT) has been used to evaluate the changes of retinal degeneration in patients with diabetic peripheral neuropathy (DPN) in recent years, but the results of previous studies were controversial. Therefore, a systematic review and meta-analysis was performed to evaluate the degree of retinal neurodegeneration in DPN measured by OCT. Methods: A comprehensive search of PubMed, Embase, Web of Science, Scopus, China Biomedical Literature (CBM), China National Knowledge Infrastructure (CNKI), VIP, and Wanfang databases were performed to identify studies that evaluate retinal neurodegeneration in DPN by using OCT. The included studies were critically reviewed and meta-analyses ...

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    10. Use of spectral domain optical coherence tomography to detect internal defects of resin composites in carious teeth after restorations

      Use of spectral domain optical coherence tomography to detect internal defects of resin composites in carious teeth after restorations

      Postoperative testing plays an important role in evaluating clinical effect of treatment of caries by filling the decayed teeth with resin composites, which mainly depends on the detection of defects at the interface between resin composites and cavity to date, without considering the internal defects of resin composites. Here, we report, for the first time, the measurement of the morphologies within resin composites by using spectral domain optical coherence tomography. Experiments were performed on the ex vivo human carious teeth after restorations, and the results showed that the tiny cracks and air bubbles within resin composites can be clearly distinguished ...

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    11. High resolution anterior segment optical coherence tomography of ocular surface lesions: A review and handbook

      High resolution anterior segment optical coherence tomography of ocular surface lesions: A review and handbook

      Introduction : High resolution anterior segment optical coherence tomography (HR-OCT) has revolutionized the way by which clinicians can diagnose and differentiate ocular surface lesions. Careful interpretation of HR-OCT images can provide morphological information about the lesion of interest and help guide the diagnosis. Areas covered : This paper reviews the steps to interpreting HR-OCT images of ocular surface lesions and summarizes their characteristic findings. Expert opinion : Among the multiple modalities available to image the ocular surface and anterior segment, HR-OCT has emerged as an instrumental tool to obtain “optical biopsies” of various ocular surface lesions. A step-by-step approach to acquiring and interpreting ...

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    12. Optical Coherence Tomography based treatment approach for patients with Acute Coronary Syndrome

      Optical Coherence Tomography based treatment approach for patients with Acute Coronary Syndrome

      Areas covered: In this review, we outline the underlying causes of acute coronary syndrome (ACS) as evaluated by optical coherence tomography (OCT). We report both the definitions of each mechanism and its frequency as reported in the literature to date. Finally, we present an algorithm based on the findings in the review that gives an outlined approach to perform intervention on ACS patients. Expert opinion: Although the most common and most accepted intervention in ACS cases is stent implantation, data suggest a stentless approach in cases of plaque erosion, which generally occurs in younger patients presenting with an acute coronary ...

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    13. Influences of hypomagnesemia on optic nerve and retinal vascular structure determined using optical coherence tomography angiography

      Influences of hypomagnesemia on optic nerve and retinal vascular structure determined using optical coherence tomography angiography

      Purpose: To evaluate the effects of low blood magnesium levels on the optic nerve, retina and retinal vascular structure. Methods: This observational and cross-sectional study was conducted between June 2019 and May 2020 with participants aged 20-39 years, who had a visual acuity of ≥20/20, axial length of 22-24.5 mm, refractive defect spherical equivalent of ≤±3D and intraocular pressure of ≤21 mm Hg. All participants had a complaint of twitching in their eyes. The participants with normal serum magnesium levels constituted the control group, and patients with hypomagnesemia constituted the patient group. Updated AngioScan software (Navis ver. 1 ...

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      Mentions: Nidek
    14. Vessel Density around Foveal Avascular Zone as a Potential Imaging Biomarker for Detecting Preclinical Diabetic Retinopathy: An Optical Coherence Tomography Angiography Study

      Vessel Density around Foveal Avascular Zone as a Potential Imaging Biomarker for Detecting Preclinical Diabetic Retinopathy: An Optical Coherence Tomography Angiography Study

      Purpose : The purpose of this study was to investigate the changes of optical coherence tomography angiography (OCTA) parameters in diabetic retinopathy (DR) using an updated software with 3D projection artifact removal. Methods : In this cross-sectional observational study, 192 eyes of 111 patients with diabetes mellitus (DM) and 55 eyes of 34 age-matched healthy subjects were included. Diabetic patients were divided into three subgroups: without DR, with mild non-proliferative DR, and with moderate-to-severe non-proliferative DR. All eyes underwent dilated fundoscopy along with 3x3mm and 6x6mm OCTA image acquisition. Vessel density (VD), retinal thickness and foveal avascular zone (FAZ) parameters were analyzed ...

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    15. Agreement between anterior segment parameters obtained by a new ultrasound biomicroscopy and a swept-source fourier-domain anterior segment optical coherence tomography

      Agreement between anterior segment parameters obtained by a new ultrasound biomicroscopy and a swept-source fourier-domain anterior segment optical coherence tomography

      Purpose To evaluate the agreement between a new UBM and a SS-OCT. Methods The scans of the right eye of each volunteer were obtained using the 2 devices. Data were fitted and recorded including: central corneal thickness (CCT), aqueous depth (AQD) (the distance from endothelium to lens), angle-to-angle distance (ATA), lens thickness (LT), diameter of the lens in the horizontal direction (LDia angle : distance between the sharp angles on both sides of the lens, LDia arc : distance between the vertex of the circular arcs on both sides of the lens), anterior and posterior corneal radius (Rf and Rb). Results 25 ...

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    16. Correlation of retinal thickness and swept-source optical coherence tomography angiography derived vascular changes in patients with neovascular age-related macular degeneration

      Correlation of retinal thickness and swept-source optical coherence tomography angiography derived vascular changes in patients with neovascular age-related macular degeneration

      Purpose: The aim of this study was to investigate whether structural OCT changes, in specific retinal thickness, is associated with the vascular response within the nAMD CNV lesion. In other words, whether SSOCTA derived parameters may prove suitable to assess CNV activity in future. Methods: During the first 3 months patients were prospectively followed with visits at days 7, and 14 after each anti-VEGF treatment up to day 90. At baseline, day 30 and 60 Aflibercept was administered. OCT-derrived retinal thickness (RT) and OCTA-derived CNV lesion parameters (vessel area [VA]), total vessel length [TVL], total number of junctions [TNJ], junction ...

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    17. Long-term follow-up of adult patient with neurofibromatosis type 1 with retinal astrocytic hamartoma using spectral-domain optical coherence tomography: a review of the literature and a report of a case

      Long-term follow-up of adult patient with neurofibromatosis type 1 with retinal astrocytic hamartoma using spectral-domain optical coherence tomography: a review of the literature and a report of a case

      Background : Retinal astrocytic hamartoma (RAH) is a tumor that can be sporadic or in the context of tuberous sclerosis complex (TSC) and has been reported to be associated with neurofibromatosis type 1 (NF1) in a few cases. Patient and methods : A 65-year-old male patient with NF1 was referred for ophthalmological evaluation. Comprehensive examination, near-infrared reflectance (NIR), spectral-domain optical coherence tomography (SDOCT), fluorescein angiography (FFA), and indocyanine green angiography (ICGA) were carried out. The follow-up of the patient was at 4 and 7 years. Results : Best-corrected visual acuity (BCVA) was 20/20 in both eyes. Anterior segment examination revealed bilateral Lisch ...

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    18. Retinal vascularity, nerve fiber, and ganglion cell layer thickness in thyroid eye disease on optical coherence tomography angiography

      Retinal vascularity, nerve fiber, and ganglion cell layer thickness in thyroid eye disease on optical coherence tomography angiography

      Purpose : To compare the retinal vascularity, peripapillary vascularity, nerve fiber layer thickness and ganglion cell layer thickness between active, inactive thyroid eye disease (TED) and healthy eyes. Methods : Retrospective comparative cross-sectional cohort study. Patients with TED, active and inactive on the VISA score, and healthy eyes were included. All patients underwent optical coherence tomography angiography with detailed demographic and clinical data capture. Using automated software, retinal and peripapillary vascularity index, nerve fiber layer thickness, and ganglion cell layer thickness were calculated and were compared between the groups. Results : Twenty-four eyes with active TED, 102 eyes with inactive TED and 52 ...

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    19. Optical Coherence Tomography Angiography in Uveitic Glaucoma – A Pilot Study

      Optical Coherence Tomography Angiography in Uveitic Glaucoma – A Pilot Study

      Purpose : To compare vessel density (VD) as measured by optical coherence tomography angiography (OCTA), in uveitic eyes with secondary glaucoma (UG) with VD in uveitic eyes without glaucoma (UV), eyes with primary open-angle glaucoma (POAG), and healthy eyes (HY). Methods : VD was measured at the following segmentation areas: radial peripapillary capillaries, superficial (SL) and deep vascular plexus (DL) and choroid. Results : The majority of the measured papillary areas showed significantly lower VD in the UG group than in the HY group. In macular area, in the superficial vascular plexus wholeVD was significantly lower than in the healthy group, as well ...

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    20. Quantification of retinal microvascular density using optic coherence tomography angiography in primary angle closure disease

      Quantification of retinal microvascular density using optic coherence tomography angiography in primary angle closure disease

      Purpose : To evaluate the microvascular density of the peripapillary and parafoveal areas of the eyes with primary angle closure disease (PACD) using optical coherence tomography angiography (OCTA). Materials and methods : An observational study was conducted with 76 PACD patients (29 eyes with primary angle closure suspect, 22 eyes with primary angle closure [PAC], and 25 eyes with primary angle closure glaucoma [PACG]) and 27 control eyes. OCTA was performed for all subjects to acquire a 4.5 × 4.5 mm scanning area centered on the optic discs and a 3 × 3 mm parafoveal cubes. Peripapillary and parafoveal vessel density (VD ...

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    21. Optical coherence tomography confirms shunt malfunction and recurrence of raised intracranial pressure in optic atrophy

      Optical coherence tomography confirms shunt malfunction and recurrence of raised intracranial pressure in optic atrophy

      Background Investigating potential cerebrospinal fluid (CSF) shunt malfunction can be a challenge. Optical coherence tomography (OCT), a non-invasive imaging technique, is used to monitor changes at the optic nerve head in papilloedema. Conventional teaching suggests that in the presence of optic atrophy the optic nerve head may not re-swell in response to a relapse in raised intracranial pressure (ICP). Methods A retrospective case series of three patients who had prior CSF diversion surgery for idiopathic intracranial cranial hypertension (IIH) is presented demonstrating the benefit of non-invasive OCT imaging confirming raised ICP. Results Recurrence of raised ICP, due to malfunctioning CSF ...

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    22. Diagnostic Value of Optical Coherence Tomography in the Early Diagnosis of Macular Complications in Chronic Vogt-Koyanagi-Harada Disease

      Diagnostic Value of Optical Coherence Tomography in the Early Diagnosis of Macular Complications in Chronic Vogt-Koyanagi-Harada Disease

      Purpose: To describe the role of optical coherence tomography (OCT) in detecting subclinical choroidal inflammation and early diagnosis of macular complications in chronic Vogt-Koyanagi-Harada (VKH) disease with sunset glow fundus. Methods: Retrospective observational study. Clinical features, OCT images, treatment, and visual outcome were analyzed. Results: Fourteen patients (9 females and 5 males) were included in the study. Mean age was 39 years (range 7-67 years). Mean duration of disease was 5.25 years (range 1-15 years). Anterior uveitis was seen in 14 eyes (52%). Fundus examination showed sunset glow fundus in all patients with no obvious macular pathology. OCT showed ...

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    23. Endoscopic imaging in inflammatory bowel disease: current developments and emerging strategies

      Endoscopic imaging in inflammatory bowel disease: current developments and emerging strategies

      Developments in enhanced and magnified endoscopy have signified major advances in endoscopic imaging of ileocolonic pathology in inflammatory bowel disease (IBD). Artificial intelligence is increasingly being used to augment the benefits of these advanced techniques. Nevertheless, treatment of IBD patients is frustrated by high rates of non-response to therapy, while delayed detection and failures to detect neoplastic lesions impede successful surveillance. A possible solution is offered by molecular imaging, which adds functional imaging data to mucosal morphology assessment through visualizing biological parameters. Other label-free modalities enable visualization beyond the mucosal surface without the need of tracers.

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    24. Non-invasive Survey of Rubens’ Ceiling Paintings at the Banqueting House Whitehall, London, by Means of Optical Coherence Tomography

      Non-invasive Survey of Rubens’ Ceiling Paintings at the Banqueting House Whitehall, London, by Means of Optical Coherence Tomography

      This article presents the results of the examination by means of optical coherence tomography (OCT) of two of the nine monumental ceiling paintings by Peter Paul Rubens and his studio, still located in their original location at the Banqueting House, the only surviving building of the former Whitehall Palace in London. OCT is a non-invasive technique of structural imaging of layers semi-permeable to infrared light. The aim of the 2018 research campaign at the Banqueting House, conducted within the MOLAB programme under the IPERION CH project, was to determine the present condition of the paintings and thus inform decisions about ...

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