1. Articles from thieme-connect.de

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    1. Analysis of the Vascular Morphology of the Fibrotic Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration Using Optical Coherence Tomography Angiography

      Analysis of the Vascular Morphology of the Fibrotic Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration Using Optical Coherence Tomography Angiography

      Purpose Choroidal neovascularization (CNV) in neovascular age-related macular degeneration (nAMD) undergoing anti-VEGF therapy transforms into a fibrotic lesion. This fibrovascular transformation is associated with a great variety of functional and morphological effects. The aim of this study was to investigate the vascular morphology of fibrotic CNV, to compare it with its surrounding tissue and to identify phenotypes using optical coherence tomography angiography (OCTA). Methods In 18 eyes with fibrotic CNV in nAMD spectral domain OCT (SD-OCT) and OCTA were performed. The automated segmentation lines were manually adjusted. A slab from 60 µm beneath Bruchʼs membrane to the inner edge of ...

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    2. Spectral Domain-Optical Coherence Tomography and Optical Coherence Tomography Angiography Findings in a Case of Acute Syphilitic Posterior Placoid Chorioretinitis

      Spectral Domain-Optical Coherence Tomography and Optical Coherence Tomography Angiography Findings in a Case of Acute Syphilitic Posterior Placoid Chorioretinitis

      Ocular syphilis can involve almost any structure of the eye, but posterior uveitis and panuveitis are the most common [ 1 ]. Additional manifestations may include anterior uveitis, optic neuropathy, retinal vasculitis, interstitial keratitis, and serous and exudative retinal detachment [ 2 ], [ 3 ]. Ocular syphilis may lead to decreased visual acuity, including permanent blindness. It can also be associated with neurosyphilis [ 4 ]. Both ocular and neurosyphilis can occur at any stage of syphilis, including primary and secondary involvement. Syphilitic uveitis may occur as early as 6 weeks after the primary inoculation and may be the only presenting systemic sign of syphilis. Only a ...

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    3. Optical Coherence Tomography Analysis of Cystoid Macular Edema in Retinal Dystrophy Treated with Oral Acetazolamide: Two Cases

      Optical Coherence Tomography Analysis of Cystoid Macular Edema in Retinal Dystrophy Treated with Oral Acetazolamide: Two Cases

      Enhanced S-cone syndrome (ESCS) is an autosomal recessive retinal dystrophy associated with a NR2E3 mutation, causing night blindness, decreased visual acuity, and visual field defects [ 1 ]. Clinically, ESCS is characterized by annular pigmentation along the vascular arcades and macular abnormalities [ 2 ]. Best vitelliform macular dystrophy (BVMD) is also an autosomal but dominant hereditary retinal dystrophy associated with the BEST1 gene, which affects central vision with a relatively good prognosis and presents macular egg yolk yellow lesions [ 3 ]. A common characteristic of retinal dystrophies including ESCS and BVMD is the cystic macular lesions that appear in the retina and cause visual ...

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    4. Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography

      Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography

      Background  This study aimed to evaluate the use of ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography (OCT) with micromotor catheters for the in vivo assessment of Barrett’s esophagus and dysplasia. Methods  74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology (49 nondysplastic Barrett’s esophagus [NDBE], 25 neoplasia) were obtained from 14 patients with Barrett’s esophagus and a history of dysplasia and 30 with NDBE. The associations between irregular mucosal patterns on en face OCT, absence of mucosal layering, surface signal > subsurface, and > 5 atypical glands on cross-sectional OCT vs. histology and treatment history were ...

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    5. OCT Angiography (Textbook)

      OCT Angiography (Textbook)

      OCT Angiography by David R. Chow and a cadre of renowned authors is an authoritative, richly illustrated guide on a groundbreaking new ophthalmic imaging technique. Optical coherence tomography angiography is revolutionizing ophthalmologic diagnosis and management of retinal disease. The technology is transforming the ocular disease diagnostic paradigm - from the retina to the choroid - enabling precision-tailored patient management. Noninvasive and more sophisticated than fluorescein angiography, OCTA obviates the need for dye and yields an unprecedented level of detail. The layered visualization of the retina and choroid vasculature delivers greater understanding of retinal disease. From sight-robbing eye diseases affecting millions such as ...

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    6. Spectral Domain Optical Coherence Tomography (SD-OCT) Findings in Refsumʼs Disease

      Spectral Domain Optical Coherence Tomography (SD-OCT) Findings in Refsumʼs Disease

      Refsumʼs disease (OMIM 266500) is a very rare (about 60 cases have been reported worldwide) autosomal recessive inherited peroxisomal error of lipid metabolism with impaired alpha-oxidation of branched fatty acids that leads to an accumulation of phytanic acid in tissues and plasma [ 1 ]. Various mutations of genes like PEX7 (encodes PTS2 receptor) or PHYH (encodes phytanoyl-CoA hydroxylase) are associated with Refsumʼs disease. Most cases are detected by the clinical manifestations in the early childhood. Typical clinical signs are retinitis pigmentosa, cerebellar ataxia and peripheral neuropathy. Other symptoms are acustic nerve deafness, cardiomyopathy, cutaneous ichthyosis, and epiphysial dysplasia [ 2 ], [ 3 ]. Patients ...

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    7. Diagnosis of an Invisible Iris Cyst Using Autorefractometry and Anterior Segment Optical Coherence Tomography

      Diagnosis of an Invisible Iris Cyst Using Autorefractometry and Anterior Segment Optical Coherence Tomography

      Iris and ciliary body cysts are epithelium-lined spaces arising from their pigment epithelial layer. While they are stable and asymptomatic in most cases, multiple, circumferential cysts can cause angle closure glaucoma [ 1 ], [ 2 ]. A recent case report described the use of autorefractometry, which may be used during routine examination e.g. by optometrists or opticians, to detect asymptomatic iris cysts [ 3 ]. We describe a similar case where autorefractometry aided in the detection of an iris cyst and used anterior segment optic coherence tomography (AS-OCT) to confirm the diagnosis.

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    8. Biophotonic endoscopy: a review of clinical research techniques for optical imaging and sensing of early gastrointestinal cancer

      Biophotonic endoscopy: a review of clinical research techniques for optical imaging and sensing of early gastrointestinal cancer

      Detection, characterization, and staging constitute the fundamental elements in the endoscopic diagnosis of gastrointestinal diseases, but histology still remains the diagnostic gold standard. New developments in endoscopic techniques may challenge histopathology in the near future. An ideal endoscopic technique should combine a wide-field, “red flag” screening technique with an optical contrast or microscopy method for characterization and staging, all simultaneously available during the procedure. In theory, biophotonic advances have the potential to unite these elements to allow in vivo “optical biopsy.” These techniques may ultimately offer the potential to increase the rates of detection of high risk lesions and the ...

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    9. Neuroimaging of the afferent visual system

      Neuroimaging of the afferent visual system

      Neuroimaging studies provide a useful tool for the clinician evaluating a patient with visual loss. In this review, we discuss the use of magnetic resonance imaging (MRI), computed tomography (CT), orbital ultrasound, and optical coherence tomography (OCT) for evaluating causes of visual loss affecting the afferent visual system. The imaging characteristics of diseases affecting the optic nerve, orbit, sellar and parasellar region, optic tracts, and retrogeniculate visual pathways will be discussed.

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    10. Biased assessment of 3D optical coherence tomography in a single post-radiofrequency ablation patient without histological correlation

      case report entitled “Three-dimensional optical coherence tomography of Barrett’s esophagus and buried glands beneath neosquamous epithelium following radiofrequency ablation,” was recently published by Adler et al. in Endoscopy [1]. Based on the title and abstract, we fully expected the authors to present evidence showing that three-dimensional optical coherence tomography (3D-OCT) was able to detect buried Barrett’s after radiofrequency ablation (RFA) that was otherwise not detectable with conventional methods. Unfortunately, the authors report a single ablation-naïve case where it seems that buried glands were detected on biopsy yet not specifically detected with 3D-OCT or explicitly described in their findings ...
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    1-10 of 10
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