1. Articles from thieme-connect.de

  2. 1-24 of 24
    1. Differences in Mean Values and Variance in Quantitative Analyses of Foveal OCTA Imaging

      Differences in Mean Values and Variance in Quantitative Analyses of Foveal OCTA Imaging

      Purpose: Multiple approaches for quantifying parameters such as vessel density (VD) and vessel length density (VLD) in optical coherence tomography angiography (OCTA) en-face segmentations are currently available. While it is common knowledge that data gathered from different methods should not be directly compared to each other, a comparison of the different methods can help to further the understanding of differences between different methods of measurement. Here we compare a common method of semiautomatically quantifying VD and VLD with an automated method supplied by the manufacturer of an OCTA device and report on differences in performance in order to probe for ...

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    2. Subthreshold Photocoagulation, Laser Endpoint Management Based on Optical Coherence Tomography Angiography in Cases of Diabetic Macular Edema Refractory to Anti-VEGF

      Subthreshold Photocoagulation, Laser Endpoint Management Based on Optical Coherence Tomography Angiography in Cases of Diabetic Macular Edema Refractory to Anti-VEGF

      Purpose: This study aimed to determine the changes that occur in the vasculature, as based on optical coherence tomography angiography (OCTA) after non-damaging endpoint management (EpM), using a continuous wave yellow laser. The study was on eyes with diabetic macular edema (DME) that were resistant to anti-vascular endothelial growth factors (anti-VEGFs). Materials and methods: This was a retrospective analysis of OCTA images of 44 eyes in 44 patients with DME refractory to anti-VEGF. The eyes were treated with a PASCAL Streamline yellow laser (577 nm wavelength, 200 mm spot size). Treatment was administered to the DME area and utilized 10 ...

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    3. Diagnostic Reliability of Optical Coherence Tomography Biomarkers for Postsurgical Success in Visual Acuity in Patients with Idiopathic Epiretinal Membranes

      Diagnostic Reliability of Optical Coherence Tomography Biomarkers for Postsurgical Success in Visual Acuity in Patients with Idiopathic Epiretinal Membranes

      Introduction: Several optical coherence tomography (OCT) biomarkers for postsurgical success in patients with idiopathic epiretinal membranes (iERMs) have been described in single predictor analyses. The aim of this study was to assess the reliability of diagnosis of OCT biomarkers and to calculate their impact on postsurgical visual acuity by applying multiple regression analysis. Methods: This retrospective study included patients scheduled for pars plana vitrectomy with membrane peeling for iERMs. Presurgical OCT scans were analyzed for the presence of OCT biomarkers by two reviewers. Intra- and interobserver reliability was calculated with the Kuder-Richardson 20 test. Results: Among the 136 patients included ...

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    4. A Pediatric COVID-19 Study: Retinal Nerve Fiber Layer, Ganglion Cell Layer, and Alterations in Choroidal Thickness in Swept-Source OCT Measurements

      A Pediatric COVID-19 Study: Retinal Nerve Fiber Layer, Ganglion Cell Layer, and Alterations in Choroidal Thickness in Swept-Source OCT Measurements

      Purpose: To investigate early covid measurements of central macular thickness (CMT), retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) thickness, and choroidal thickness (ChT) in children recovered from coronavirus disease 2019 (COVID-19). Methods: This cross-sectional study was carried out 4 weeks after completed COVID-19 treatment. The diagnosis of the Alpha variant COVID-19 was made by the polymerase chain reaction test after prediagnosis with clinical, laboratory, and radiological findings. A total of 46 children were included in the study. Pediatric patients who received COVID-19 treatment comprised the COVID-19 group (24 children), and healthy children were enrolled in the control group ...

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    5. Effects of B12 Deficiency Anemia on Radial Peripapillary and Macular Vessel Density: An Optical Coherence Tomography Angiography (OCTA) Study

      Effects of B12 Deficiency Anemia on Radial Peripapillary and Macular Vessel Density: An Optical Coherence Tomography Angiography (OCTA) Study

      Background: To evaluate the macular and optic disc vascular changes in vitamin B12 deficiency anemia. Methods: A total of 24 patients with vitamin B12 deficiency anemia and 24 healthy controls were involved in this study. All participants were evaluated for central macular thickness (CMT), peripapillary retina nerve fiber layer (RNFL) thickness, foveal avascular zone (FAZ) area, macular vessel density (VD) in superficial capillary plexus (SCP) and deep capillary plexus (DCP), choriocapillaris flow area, and optic disc radial peripapillary capillary (RPC) VD using optic coherence tomography (OCT) and optic coherence tomography angiography (OCTA). Metabolic parameters were also noted. Results: Temporal RNFL ...

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    6. Analysis of the Thickness of the Outer Retinal Layer Using Optical Coherence Tomography - A Predictor of Visual Acuity in Schizophrenia

      Analysis of the Thickness of the Outer Retinal Layer Using Optical Coherence Tomography - A Predictor of Visual Acuity in Schizophrenia

      Background: The aim of this study was to evaluate the thickness of the outer retinal layer (ORL) together with macular thickness and changes in the retinal nerve fiber layer (RNFL) in patients with schizophrenia in comparison with healthy controls. Methods: This study included 114 eyes of 57 patients diagnosed with schizophrenia and 114 eyes of 57 healthy controls. Central foveal thickness (CFT), central macular thickness (CMT), and ORL thickness were measured in both groups via the images obtained by spectral-domain optical coherence tomography (SD-OCT). RNFL was also assessed in four quadrants (inferior, superior, temporal, nasal). CMT measurements were presented as ...

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    7. Three Technologies That Will Guide Revascularization of Chronic Coronary Syndrome Patients into the 21st Century: A Review

      Three Technologies That Will Guide Revascularization of Chronic Coronary Syndrome Patients into the 21st Century: A Review

      Although medical therapy is the preferred first-line treatment for patients with chronic coronary syndrome (CCS), revascularization remains an important consideration. We present a review that identifies the three diagnostic technologies most important to guiding the decision to revascularize patients with CCS: (1) cardiac computed tomography, (2) intracoronary imaging, and (3) lesion-specific physiological guidance.

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    8. Comparison of the Thickness of the Fiber Layer of the Retinal Nerves in Spectral Domain Optical Coherence Tomography in Normal Eyes Older Than 40 Years

      Comparison of the Thickness of the Fiber Layer of the Retinal Nerves in Spectral Domain Optical Coherence Tomography in Normal Eyes Older Than 40 Years

      Purpose: To compare measurements of the thickness of the retinal nerve fibre layer (RNFL) and assess the agreement between three different devices for spectral domain optical coherence tomography. Material and methods: The RNFL thickness of both eyes of 23 normal subjects older than 40 years was measured using Canon HS100, Topcon Maestro, and NIDEK RS-3000 devices. Both eyes of each subject were scanned in random order. All scans were completed on the same day in the morning. The average and four quadrants (superior, inferior, nasal, and temporal) of RNFL thickness were measured. To determine the differences in RNFL thickness, analysis ...

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    9. Reliability of Corneal, Epithelial, and Stromal Thickness Mapping for a 9-mm Zone Using Spectral-Domain Optical Coherence Tomography

      Reliability of Corneal, Epithelial, and Stromal Thickness Mapping for a 9-mm Zone Using Spectral-Domain Optical Coherence Tomography

      Purpose: To evaluate the reliability of spectral-domain optical coherence tomography (SD-OCT; RTVue XR; Optovue, Inc., Fremont, CA, USA) for thickness mapping of the entire cornea (CT), corneal epithelium (ET). and corneal stroma (ST) over a 9-mm zone in healthy eyes. We sought to develop reference values for different age groups and elucidate potential sex- and age-dependent characteristics of corneal sublayer pachymetry maps. Methods: Three consecutive SD-OCT scans were obtained in 166 healthy right eyes (mean age = 50 ± 20 years). The thickness maps contain 25 sectors over a 9-mm diameter zone. To test measurement reliability, intraclass correlation coefficients (ICC), coefficients of ...

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    10. Optical Coherence Tomography of the Coronary Arteries

      Optical Coherence Tomography of the Coronary Arteries

      Intravascular imaging, particularly optical coherence tomography, has brought significant improvement in diagnostic and therapeutical approaches to coronary artery disease and has offered superior high-resolution visualization of coronary arteries. The ability to obtain images of intramural and transmural coronary structures allows the study of the process of atherosclerosis, effect of therapies, mechanism of acute coronary syndrome and stent failure, and performance of new devices and enables the interventional cardiologist to optimize the effect of percutaneous coronary intervention. In this review, we provide the summary of the latest published data on clinical use of optical coherence tomography as well as practical algorithm ...

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    11. Intraoperative OCT – Real-World User Evaluation in Routine Surgery

      Intraoperative OCT – Real-World User Evaluation in Routine Surgery

      Background In recent years, great progress has been made in intraoperative imaging using optical coherence tomography (iOCT). There are now several commercially available iOCT systems that allow high-resolution imaging of all structures of the eye without interrupting surgery. This real-time visualisation can provide additional information to conventional surgical microscopy, but is relatively expensive. The aim of our study was to find out how often OCT integrated into the surgical microscope is used by trained surgeons, or to what extent they consider that iOCT is relevant for intraoperative procedures. Patients and Methods A prospective monocentric analysis was conducted of the field ...

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      Mentions: Leica
    12. Assessment of Retinal Neurodegeneration and Choroidal Thickness in COVID-19 Patients Using Swept-Source OCT Technology

      Assessment of Retinal Neurodegeneration and Choroidal Thickness in COVID-19 Patients Using Swept-Source OCT Technology

      Purpose: To analyze the central macular thickness (CMT), retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), and choroidal thickness (ChT) measurements in patients with coronavirus disease 2019 (COVID-19). Methods: The study was conducted cross-sectionally 4 weeks after the completed treatment of COVID-19. The diagnosis of COVID-19 was based on the polymerase chain reaction test and/or clinical and radiological findings. The patients with treated COVID-19 were enrolled in the COVID-19 group; age- and sex-matched healthy participants served as the control group. All patients in the COVID-19 group were hospitalized and treated with favipiravir, moxifloxacin, and heparin without ...

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    13. Quantification of Early and Intermediate Age-related Macular Degeneration Using OCT "en face" Presentation

      Quantification of Early and Intermediate Age-related Macular Degeneration Using OCT "en face" Presentation

      Background: Early and intermediate age-related macular degeneration (AMD) results in drusen deposits under the retinal pigment epithelium (RPE). These early stages of AMD exhibit different risks of progressing to late AMD. To date, early AMD has been classified and quantified by fundus photography. This does not appear to be sensitive enough for clinical trials studying the impact on drusen. SD-OCT with two-dimensional rendering of the segmented slices analysed allows for en face imaging of the drusen. The present trial studied the potential of quantifying early and intermediate AMD by en-face optical coherence tomography (OCT). Material and methods: Thirty-one eyes of ...

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      Mentions: Visionix
    14. Evaluation of a Self-Imaging SD-OCT System for Remote Monitoring of Patients with Neovascular Age Related Macular Degeneration

      Evaluation of a Self-Imaging SD-OCT System for Remote Monitoring of Patients with Neovascular Age Related Macular Degeneration

      Background: The treatment of patients with neovascular age-related macular degeneration (nAMD) requires frequent office visits to identify fluid in the retina that requires treatment. Frequent office-based examinations using optical coherence tomography (OCT) are a burden on patients and their care givers. The development of OCT systems that can be self-operated by patients at home offers the potential for precise remote monitoring and improved individualized therapy. Patients/material and methods: An investigational spectral domain OCT system (Notal Vision Home OCT, NVHO) for automatic patient-guided self-imaging intended for commercialization was evaluated in a total of 69 study participants with neovascular age-related macular ...

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      Mentions: Notal Vision
    15. Analysis of the Vascular Morphology of the Fibrotic Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration Using Optical Coherence Tomography Angiography

      Analysis of the Vascular Morphology of the Fibrotic Choroidal Neovascularization in Neovascular Age-Related Macular Degeneration Using Optical Coherence Tomography Angiography

      Purpose Choroidal neovascularization (CNV) in neovascular age-related macular degeneration (nAMD) undergoing anti-VEGF therapy transforms into a fibrotic lesion. This fibrovascular transformation is associated with a great variety of functional and morphological effects. The aim of this study was to investigate the vascular morphology of fibrotic CNV, to compare it with its surrounding tissue and to identify phenotypes using optical coherence tomography angiography (OCTA). Methods In 18 eyes with fibrotic CNV in nAMD spectral domain OCT (SD-OCT) and OCTA were performed. The automated segmentation lines were manually adjusted. A slab from 60 µm beneath Bruchʼs membrane to the inner edge of ...

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    16. Spectral Domain-Optical Coherence Tomography and Optical Coherence Tomography Angiography Findings in a Case of Acute Syphilitic Posterior Placoid Chorioretinitis

      Spectral Domain-Optical Coherence Tomography and Optical Coherence Tomography Angiography Findings in a Case of Acute Syphilitic Posterior Placoid Chorioretinitis

      Ocular syphilis can involve almost any structure of the eye, but posterior uveitis and panuveitis are the most common [ 1 ]. Additional manifestations may include anterior uveitis, optic neuropathy, retinal vasculitis, interstitial keratitis, and serous and exudative retinal detachment [ 2 ], [ 3 ]. Ocular syphilis may lead to decreased visual acuity, including permanent blindness. It can also be associated with neurosyphilis [ 4 ]. Both ocular and neurosyphilis can occur at any stage of syphilis, including primary and secondary involvement. Syphilitic uveitis may occur as early as 6 weeks after the primary inoculation and may be the only presenting systemic sign of syphilis. Only a ...

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    17. Optical Coherence Tomography Analysis of Cystoid Macular Edema in Retinal Dystrophy Treated with Oral Acetazolamide: Two Cases

      Optical Coherence Tomography Analysis of Cystoid Macular Edema in Retinal Dystrophy Treated with Oral Acetazolamide: Two Cases

      Enhanced S-cone syndrome (ESCS) is an autosomal recessive retinal dystrophy associated with a NR2E3 mutation, causing night blindness, decreased visual acuity, and visual field defects [ 1 ]. Clinically, ESCS is characterized by annular pigmentation along the vascular arcades and macular abnormalities [ 2 ]. Best vitelliform macular dystrophy (BVMD) is also an autosomal but dominant hereditary retinal dystrophy associated with the BEST1 gene, which affects central vision with a relatively good prognosis and presents macular egg yolk yellow lesions [ 3 ]. A common characteristic of retinal dystrophies including ESCS and BVMD is the cystic macular lesions that appear in the retina and cause visual ...

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    18. Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography

      Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography

      Background  This study aimed to evaluate the use of ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography (OCT) with micromotor catheters for the in vivo assessment of Barrett’s esophagus and dysplasia. Methods  74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology (49 nondysplastic Barrett’s esophagus [NDBE], 25 neoplasia) were obtained from 14 patients with Barrett’s esophagus and a history of dysplasia and 30 with NDBE. The associations between irregular mucosal patterns on en face OCT, absence of mucosal layering, surface signal > subsurface, and > 5 atypical glands on cross-sectional OCT vs. histology and treatment history were ...

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    19. OCT Angiography (Textbook)

      OCT Angiography (Textbook)

      OCT Angiography by David R. Chow and a cadre of renowned authors is an authoritative, richly illustrated guide on a groundbreaking new ophthalmic imaging technique. Optical coherence tomography angiography is revolutionizing ophthalmologic diagnosis and management of retinal disease. The technology is transforming the ocular disease diagnostic paradigm - from the retina to the choroid - enabling precision-tailored patient management. Noninvasive and more sophisticated than fluorescein angiography, OCTA obviates the need for dye and yields an unprecedented level of detail. The layered visualization of the retina and choroid vasculature delivers greater understanding of retinal disease. From sight-robbing eye diseases affecting millions such as ...

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    20. Spectral Domain Optical Coherence Tomography (SD-OCT) Findings in Refsumʼs Disease

      Spectral Domain Optical Coherence Tomography (SD-OCT) Findings in Refsumʼs Disease

      Refsumʼs disease (OMIM 266500) is a very rare (about 60 cases have been reported worldwide) autosomal recessive inherited peroxisomal error of lipid metabolism with impaired alpha-oxidation of branched fatty acids that leads to an accumulation of phytanic acid in tissues and plasma [ 1 ]. Various mutations of genes like PEX7 (encodes PTS2 receptor) or PHYH (encodes phytanoyl-CoA hydroxylase) are associated with Refsumʼs disease. Most cases are detected by the clinical manifestations in the early childhood. Typical clinical signs are retinitis pigmentosa, cerebellar ataxia and peripheral neuropathy. Other symptoms are acustic nerve deafness, cardiomyopathy, cutaneous ichthyosis, and epiphysial dysplasia [ 2 ], [ 3 ]. Patients ...

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    21. Diagnosis of an Invisible Iris Cyst Using Autorefractometry and Anterior Segment Optical Coherence Tomography

      Diagnosis of an Invisible Iris Cyst Using Autorefractometry and Anterior Segment Optical Coherence Tomography

      Iris and ciliary body cysts are epithelium-lined spaces arising from their pigment epithelial layer. While they are stable and asymptomatic in most cases, multiple, circumferential cysts can cause angle closure glaucoma [ 1 ], [ 2 ]. A recent case report described the use of autorefractometry, which may be used during routine examination e.g. by optometrists or opticians, to detect asymptomatic iris cysts [ 3 ]. We describe a similar case where autorefractometry aided in the detection of an iris cyst and used anterior segment optic coherence tomography (AS-OCT) to confirm the diagnosis.

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    22. Biophotonic endoscopy: a review of clinical research techniques for optical imaging and sensing of early gastrointestinal cancer

      Biophotonic endoscopy: a review of clinical research techniques for optical imaging and sensing of early gastrointestinal cancer

      Detection, characterization, and staging constitute the fundamental elements in the endoscopic diagnosis of gastrointestinal diseases, but histology still remains the diagnostic gold standard. New developments in endoscopic techniques may challenge histopathology in the near future. An ideal endoscopic technique should combine a wide-field, “red flag” screening technique with an optical contrast or microscopy method for characterization and staging, all simultaneously available during the procedure. In theory, biophotonic advances have the potential to unite these elements to allow in vivo “optical biopsy.” These techniques may ultimately offer the potential to increase the rates of detection of high risk lesions and the ...

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    23. Neuroimaging of the afferent visual system

      Neuroimaging of the afferent visual system

      Neuroimaging studies provide a useful tool for the clinician evaluating a patient with visual loss. In this review, we discuss the use of magnetic resonance imaging (MRI), computed tomography (CT), orbital ultrasound, and optical coherence tomography (OCT) for evaluating causes of visual loss affecting the afferent visual system. The imaging characteristics of diseases affecting the optic nerve, orbit, sellar and parasellar region, optic tracts, and retrogeniculate visual pathways will be discussed.

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    24. Biased assessment of 3D optical coherence tomography in a single post-radiofrequency ablation patient without histological correlation

      case report entitled “Three-dimensional optical coherence tomography of Barrett’s esophagus and buried glands beneath neosquamous epithelium following radiofrequency ablation,” was recently published by Adler et al. in Endoscopy [1]. Based on the title and abstract, we fully expected the authors to present evidence showing that three-dimensional optical coherence tomography (3D-OCT) was able to detect buried Barrett’s after radiofrequency ablation (RFA) that was otherwise not detectable with conventional methods. Unfortunately, the authors report a single ablation-naïve case where it seems that buried glands were detected on biopsy yet not specifically detected with 3D-OCT or explicitly described in their findings ...
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