Purpose: To investigate the use of imaging modalities in the volumetric measurement of the subretinal space and examine the volume of subretinal blebs created by a subretinal drug delivery device utilizing microscope-integrated optical coherence tomography (MIOCT). Methods: An MIOCT image-based volume measurement method was developed and assessed for accuracy and reproducibility by imaging ceramic spheres of known size that were surgically implanted into ex vivo porcine eyes. This method was then used to measure subretinal blebs created in 10 porcine eyes by injection of balanced salt solution utilizing a subretinal delivery device via a suprachoroidal cannula. Bleb volumes obtained from ...

Objective: To explore the changes of anatomical biological parameters and dynamic parameters of the anterior segment (AS) before and after primary angle closure glaucoma (PACG) surgery. Methods: The clinical data of 82 patients (82 eyes) who underwent phacoemulsification in our hospital were retrospectively analyzed and divided into group A (angle closure, n = 38) and group B (normal open angle, n = 44). The anatomical biological parameters and dynamic parameters were compared between the two groups before and after surgery. Results: Compared with group B, group A had smaller anterior chamber depth, higher vaulting, greater iris curvature, and smaller TISA500. Compared with ...

Use of animal models for human vision research is now pervasive. To address a range of technical challenges, laboratories either modify existing equipment or purchase products that are purpose designed. Three-dimensional (3D) printing technology now allows the do-it-yourself capability to invent, innovate, and manufacture for a specific purpose. Ophthalmic imaging is often used with a range of other sophisticated experimental retinal imaging techniques, such as spectral domain optical coherence tomography (SD-OCT). The handheld smartphone camera and cost-effective, readily available professional-quality apps now allow accessible high-definition video ophthalmic image recording. However, to our knowledge, there are few reports of adapting smartphone ...

The main purpose of this study was to assess the differences in the peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell-inner plexiform layer (GCIPL) thicknesses between subjects with megalopapilla (MP) and those with large (physiological) cup discs (LCD) measured by spectral-domain optical coherence tomography. The secondary purpose was to determine whether pRNFL and GCIPL thicknesses increase with the optic nerve head (ONH) area. This cross-sectional study included 184 eyes (92 eyes with MP and 92 eyes with LCD). The subjects with LCD were used as sex-and-agematched controls. All subjects were imaged using the Cirrus HD-OCT system. Macula and pRNFL ...

Objective The purpose of the study was to use the photonic imaging modality of optical coherence tomography (OCT) to compare the marginal adaptation of composite inlays fabricated by direct and indirect techniques. Material and Methods Class II cavities were prepared on 34 extracted human molar teeth. The cavities were randomly divided into two groups according to the inlay fabrication technique. The first group was directly restored on cavities with a composite (Esthet X HD, Dentsply, Germany) after isolating. The second group was indirectly restored with the same composite material. Marginal adaptations were scanned before cementation with an invisible infrared light ...

Introduction Intracranial placement of flow-diverter (FD) stents provides a safe and effective treatment for aneurysms. 1 However, long-term angiographic follow-up is indicated, since in-stent stenosis and late thrombosis as a consequence of poor vessel wall apposition increase the risks of stroke-related complications. 1,2 In addition to conventional angiography, high-resolution contrast-enhanced cone-beam CT (VasoCT) may provide improved three-dimensional visualization of stent deployment and apposition. 2,3 Here we explored the use of VasoCT for the assessment of FD vessel wall apposition in comparison to concurrent optical coherence tomography (OCT) endoscopy. Catheter-based OCT delivers near-infrared images at a spatial resolution in ...

Optical Coherence Tomography (OCT) is an endovascular imaging modality that utilises infrared light to create high-resolution images of the vascular system. The use of OCT in cardiology is widely accepted and considered safe for imaging of the coronary artery wall, plaques and assessment of stent deployment. In the literature to date, OCT has not been used in endovascular imaging of neurovascular pathology. In this report we describe the first case in which OCT was used to evaluate pathology and assess the quality of the flow diverter treatment both directly after the treatment and at five months follow. The use of ...

Purpose Implantation of intraocular devices may become critical as they decrease in size in the future. Therefore, it is desirable to evaluate the relationship between radial location and Schwalbe’s line (smooth zone) by examining its width with scanning electron microscopy (SEM) and to correlate this with observations by optical coherence tomography (OCT). Methods Full corneoscleral rings were obtained from twenty-six formalin-fixed human phakic donor eyes. SEM of each eye yielded a complete montage of the smooth zone, from which the area was measured, and width was determined in each quadrant. In three different eyes, time domain anterior segment OCT ...

An 83-year-old man was referred for left main coronary artery (LMCA) stenting (Fig. 1A). After predilation, a 3.5 × 16-mm Promus™ drug-eluting stent (Boston Scientific Corporation; Natick, Mass) was deployed across the distal LMCA at a pressure of 16 atm (estimated diameter, 3.8 mm) (Fig. 1B). Optical coherence tomography (OCT) was performed after stent deployment (Fig. 1C). This measured the mean vessel diameter at 3.8 mm (area, 11.8 mm2) but, importantly, showed clear proximal malapposition of stent struts in the distal LMCA of up to 290 pm (Fig. 1C). Further balloon inflation of a 4 × 9-mm NC ...