1. 1-24 of 346 1 2 3 4 ... 13 14 15 »
    1. Measurement of the Inner Retinal Layers of Megalopapilla by Optical Coherence Tomography

      Measurement of the Inner Retinal Layers of Megalopapilla by Optical Coherence Tomography

      The main purpose of this study was to assess the differences in the peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell-inner plexiform layer (GCIPL) thicknesses between subjects with megalopapilla (MP) and those with large (physiological) cup discs (LCD) measured by spectral-domain optical coherence tomography. The secondary purpose was to determine whether pRNFL and GCIPL thicknesses increase with the optic nerve head (ONH) area. This cross-sectional study included 184 eyes (92 eyes with MP and 92 eyes with LCD). The subjects with LCD were used as sex-and-agematched controls. All subjects were imaged using the Cirrus HD-OCT system. Macula and pRNFL ...

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    2. Comparison of the marginal adaptation of direct and indirect composite inlay restorations with optical coherence tomography

      Comparison of the marginal adaptation of direct and indirect composite inlay restorations with optical coherence tomography

      Objective The purpose of the study was to use the photonic imaging modality of optical coherence tomography (OCT) to compare the marginal adaptation of composite inlays fabricated by direct and indirect techniques. Material and Methods Class II cavities were prepared on 34 extracted human molar teeth. The cavities were randomly divided into two groups according to the inlay fabrication technique. The first group was directly restored on cavities with a composite (Esthet X HD, Dentsply, Germany) after isolating. The second group was indirectly restored with the same composite material. Marginal adaptations were scanned before cementation with an invisible infrared light ...

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      Mentions: Thorlabs
    3. High-Resolution Optical and Angiographic CT Imaging of Flow-Diverter Stents for Assessment of Vessel Wall Apposition

      High-Resolution Optical and Angiographic CT Imaging of Flow-Diverter Stents for Assessment of Vessel Wall Apposition

      Introduction Intracranial placement of flow-diverter (FD) stents provides a safe and effective treatment for aneurysms. 1 However, long-term angiographic follow-up is indicated, since in-stent stenosis and late thrombosis as a consequence of poor vessel wall apposition increase the risks of stroke-related complications. 1,2 In addition to conventional angiography, high-resolution contrast-enhanced cone-beam CT (VasoCT) may provide improved three-dimensional visualization of stent deployment and apposition. 2,3 Here we explored the use of VasoCT for the assessment of FD vessel wall apposition in comparison to concurrent optical coherence tomography (OCT) endoscopy. Catheter-based OCT delivers near-infrared images at a spatial resolution in ...

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    4. Optical Coherence Tomography (OCT) Before and After Flowdiverter Treatment in Basilar Dolichoectasia.

      Optical Coherence Tomography (OCT) Before and After Flowdiverter Treatment in Basilar Dolichoectasia.

      Optical Coherence Tomography (OCT) is an endovascular imaging modality that utilises infrared light to create high-resolution images of the vascular system. The use of OCT in cardiology is widely accepted and considered safe for imaging of the coronary artery wall, plaques and assessment of stent deployment. In the literature to date, OCT has not been used in endovascular imaging of neurovascular pathology. In this report we describe the first case in which OCT was used to evaluate pathology and assess the quality of the flow diverter treatment both directly after the treatment and at five months follow. The use of ...

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    5. Analysis of Schwalbe's Line (Limbal Smooth Zone) by Scanning Electron Microscopy and Optical Coherence Tomography in Human Eye Bank Eyes.

      Analysis of Schwalbe's Line (Limbal Smooth Zone) by Scanning Electron Microscopy and Optical Coherence Tomography in Human Eye Bank Eyes.

      Purpose Implantation of intraocular devices may become critical as they decrease in size in the future. Therefore, it is desirable to evaluate the relationship between radial location and Schwalbe’s line (smooth zone) by examining its width with scanning electron microscopy (SEM) and to correlate this with observations by optical coherence tomography (OCT). Methods Full corneoscleral rings were obtained from twenty-six formalin-fixed human phakic donor eyes. SEM of each eye yielded a complete montage of the smooth zone, from which the area was measured, and width was determined in each quadrant. In three different eyes, time domain anterior segment OCT ...

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    6. Optical Coherence Tomography—Guided Left Main Stem Stenting

      Optical Coherence Tomography—Guided Left Main Stem Stenting

      An 83-year-old man was referred for left main coronary artery (LMCA) stenting (Fig. 1A). After predilation, a 3.5 × 16-mm Promus™ drug-eluting stent (Boston Scientific Corporation; Natick, Mass) was deployed across the distal LMCA at a pressure of 16 atm (estimated diameter, 3.8 mm) (Fig. 1B). Optical coherence tomography (OCT) was performed after stent deployment (Fig. 1C). This measured the mean vessel diameter at 3.8 mm (area, 11.8 mm2) but, importantly, showed clear proximal malapposition of stent struts in the distal LMCA of up to 290 pm (Fig. 1C). Further balloon inflation of a 4 × 9-mm NC ...

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    7. Evaluation of methylprednisolone aceponate, tacrolimus and combination thereof in the psoriasis plaque test using sum score, 20-MHz-ultrasonography and optical coherence tomography.

      Evaluation of methylprednisolone aceponate, tacrolimus and combination thereof in the psoriasis plaque test using sum score, 20-MHz-ultrasonography and optical coherence tomography.
      Background: Despite new treatment options with systemic disease modifiers, topical therapy – especially as combination therapy – plays an important role in psoriasis treatment. Methods: Antipsoriatic efficacy of methylprednisolone aceponate ointment (MPA), tacrolimus 0.1% ointment (FK506) and their combination (MPA+FK506) were investigated in a double-blind randomized pilot study using the psoriasis plaque test. Agents and corresponding placebos were applied once daily under occlusion for 11 days. Test sites were evaluated by sum score (erythema, scaling, infiltration), objective assessment by 20-MHz-sonography and optical coherence tomography (OCT). Results: After 11 days, the sum score significantly improved from baseline value in FK506-treated skin ...
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    8. Characterization of atherosclerotic plaque in patients with unstable angina pectoris and stable angina pectoris by optical coherence tomography.

      (Article in Chinese) OBJECTIVE: To compare the characterization of coronary atherosclerotic plaques in patients with unstable angina pectoris (UAP) and stable angina pectoris (SAP) by optical coherence tomography (OCT). METHODS: OCT was performed in 47 patients (23 UAP and 24 SAP) undergoing coronary angiography. Lipid-rich plaque (defined by >/= 2 quandrants of the cross-section area), thin cap fibroatheroma (TCFA), thickness of fibrous cap, plaque rupture, calcification and thrombus visualized by OCT were compared between UAP and SAP patients. RESULTS: OCT imaging was successfully in 44 out of 47 patients (22 UAP, 22 SAP). Proportion of lipid-rich plaques was similar between UAP ...
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    9. Variability of optical coherence tomography in assessment of optic disc and retinal nervous fibre layer

      (Article in Romanian) PURPOSE: To study the short-term variability of retinal nerve fiber layer (RNFL) and optic disc measurements using Stratus OCT. METHOD: Transversal comparative study with repeated measurements. For each eye, the Fast Optic Disc and Fast RNFL protocols were repeated twice in the same session. The resulted measurements were compared using correlation and variation coefficients. RESULTS: 62 eyes (34 patients) were included in the study. For every analyzed parameter there was a highly significant correlation between the first and the second measurement (p < 0.001). For the C/D ratio (vertical, horizontal and area) the correlation coefficients varied ...
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    10. New options of high resolution optical coherence tomography in glaucoma diagnostic.

      (Article in German) At present time domain optical coherence tomography (TD-OCT) plays a less important role in glaucoma diagnostics and is used mainly for macula diagnostics. The Fourier domain optical coherence tomography (FD-OCT) with enhanced resolution has new options to detect glaucoma changes. This new technology is referred as frequency domain or spectral domain OCT. This paper will present current and new options of OCT in glaucoma diagnostics. Measurements of the optic nerve head and the retinal nerve fiber layer thickness using this new technology have been shown to be reproducible. Devices which use TD-OCT (e.g. Stratus-OCT) have a ...
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    11. Sexual dysfunction in men after surgery of colorectal carcinoma. New developments in prevention and therapy

      (Article in Czech) Current procedures in the treatment of rectal carcinoma respect preservation quality of life. Development of sexual dysfunction (SD) in men after iatrogenic damage to neurovascular structures has been reported in 21-38% and significantly decreases quality of life. The author summarizes new developments in the area of surgical anatomy of Denonvilliers' fascia, occurrence of accessory pudendal arteries (APA), and neural anatomy. Introduction of robotic nerve-sparing surgery along with application of new diagnostic perioperative methods such as Doppler diagnostics and Optical Coherence Tomography will allow precise perioperative identification of neurovascular structures. New approaches in the treatment of erectile dysfunction ...
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    12. Retinal nerve fiber layer changes after cataract surgery measured by OCT: a pilot study.

      (Article in Spanish) PURPOSE: To analyze changes in peripapillary retinal nerve fiber layer (RNFL) after cataract surgery. METHODS: The average RFNL thickness of patients who underwent cataract surgery was measured using the optical coherence tomography (OCT) III Stratus(R) before surgery, the day after and one month later. The data were analyzed using the SPSS 12.0 software. We used paired two tail student's t test for comparisons. RESULTS: The study group was composed by 74 eyes of 74 patients. The RNFL thickness average was 90.71 microm (SD: 19.93), 88.30 microm (SD: 20.59) and 97 ...
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    13. Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography

      PURPOSE: Optical coherence tomography (OCT) is a minimally invasive, depth-resolved imaging tool that can be implemented in a small diameter endoscope for imaging mouse models of colorectal cancer (CRC). In this study, we utilized ultrahigh resolution (UHR) OCT to serially image the lower colon of azoxymethane (AOM) treated A/J mouse models of CRC in order to monitor the progression of neoplastic transformations and determine if OCT is capable of identifying early disease. EXPERIMENTAL DESIGN: Thirteen AOM treated A/J and two control A/J mice were surveyed at four timepoints (8, 14, 22 and 26 weeks post AOM treatment ...
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    14. Optical coherence tomography in diagnosis of urinary bladder cancer

      (Article in Russian) Optical coherence tomography (OCT) was tested in diagnosis of bladder cancer (BC) in 100 BC suspects. This method showed higher sensitivity (by 16%) in diagnosis of BC compared to standard cystoscopy as it more presicely identified squamous intraepithelial and noninvasive tumors. The analysis of OCT images was made with a noval computer program of filtration and color overlay. This improved quality of the image allowed verification or rejection of BC, its localization on urinary bladder wall. PMID: 19526873 [PubMed - in process]
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    15. Choroidal metastasis from a breast carcinoma. Diagnosis and follow-up with optical coherence tomography and fluorescein angiography and autofluorescence with Hra-ii (Heidelberg Retina Angiograph).

      Article in Spanish. CLINICAL CASE: A 69-year-old woman developed choroidal metastasis from a breast carcinoma 2 years after the initial diagnosis, surgery and chemotherapy. After treatment with palliative chemotherapy and external radiotherapy, we used fluorescein angiography (FA) and optical coherence tomography (OCT) to evaluate the resolution of the serous retinal detachment, as well as a later relapse in the optic nerve. DISCUSSION: OCT is useful in the follow-up of choroidal metastasis after treatment. However, OCT imaging is limited by the initial choroidal location of metastasis. The autofluorescence can detect exudative tumoral activity even without obvious changes in OCT or FA ...
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    16. New concepts in the invasive and non invasive evaluation of remodelling of the right ventricle and pulmonary vasculature in pulmonary arterial hypertension

      Pulmonary arterial hypertension (PAH) is a rare fatal disease defined as a sustained elevation of pulmonary arterial pressure to more than 25 mmHg at rest, with a mean pulmonary-capillary wedge pressure and left ventricular enddiastolic pressure of less than 15 mmHg at rest. Histopathology of PAH is founded on structural modifications on the vascular wall of small pulmonary arteries characterized by thickening of all its layers. These changes, named as vascular remodelling, include vascular proliferation, fibrosis, and vessel obstruction. In clinical practice the diagnosis of PAH relies on measurements of pulmonary vascular pressure and cardiac output, and calculation of pulmonary ...
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    17. OCT in acute anterior uveitis.

      (Article is Spanish). PURPOSE: To evaluate macular thickening, the state of the optic disc and retinal nerve fibers layer (RFNL) in patients with an actual episode of acute anterior uvetis (AAU) by optical coherence tomography (OCT), and compare them with a control group. METHODS: In this prospective, cross-sectional, observational and controlled study we recruited 27 consecutive eyes of 20 patients with an actual episode of AAU, age and sex-matched with 40 healthy eyes of 20 volunteers. The age ranged between 8 and 78 years old, and all were evaluated by the <>, <> and <> scans by OCT. The patients were evaluated twice ...
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    18. Fundus autofluorescence and spectral optical coherence tomography findings in a case with acute posterior multifocal placoid pigment epitheliopathy.

      We report fundus autofluorescence and spectral optical coherence tomography (OCT/SLO) findings in acute posterior multifocal placoid pigment epitheliopathy (APMPPE). Different autofluorescence patterns and OCT findings were observed during the acute and resolution phase of the disease. The combined use of new non-invasive technologies may put new insight to the explanation of the histopathology and etiology of APMPPE. PMID: 19230362 [PubMed - in process]
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    19. Update on interventional cardiology

      (Article in Spanish) Percutaneous intervention, whether coronary or noncoronary, continues to be a highly active area of medicine. This article contains an overview of the most notable developments reported in recent months. Drug-eluting stents (DESs) have provided one of the major advances in interventional cardiology as they have very effectively reduced the restenosis rate. Both randomized clinical trials and large observational studies have confirmed their safety, and their use has been extended to include highly complex conditions. Although thrombosis is one complication that can affect both conventional stents and DESs, the rate of late stent thrombosis is slightly, though significantly ...
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    20. Comparison of Spectral- and Time-Domain OCT in regard of the Automatic Detection of Central Retinal Thickness.

      (Article in German) BACKGROUND: The aim of this study was to compare macular thickness measurements obtained from time-domain optical coherence tomography (OCT) and spectral-domain OCT to evaluate their agreement. MATERIALS AND METHODS: Fifty randomly assigned subjects were included. Twenty-five were male, twenty-five female. In all cases both eyes were measured. Serial measurements were obtained from time-domain (StratusOCT, Zeiss) and spectral-domain OCT (Heidelberg Engineering, Germany). Total and regional macular thicknesses were obtained from both machines. Their agreement was estimated by Bland Altman plots. RESULTS: The foveal and total macular thicknesses measured by 3D OCT were significantly greater than those measured by ...
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    21. Pre-neoplastic bronchial lesions: possibilities of diagnosis and chemo-prevention

      (Article in Romanian) Early diagnosis of pulmonary cancer is crucial in the fight against this disease. Pre-neoplastic bronchial lesions are the first stage in the evolution towards invasive cancers. This paper describes histological patterns of these pre-neoplastic bronchial lesions, as well as early, intermediate and late molecular disturbancies associated with this condition. The ways to early identification of these lesions are: a) bronchoscopy with laser-induced auto-fluorescence guided through Optical Coherence Tomography, which is able to identify celular and extracelular structures, from the celular surface or beneath it; b) PET-CT which identifies lesions over 6 mm; c) bio-markers: the sensitivity of ...
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    22. Neuro-ophthalmological manifestations of pituitary adenomas. The usefulness of optical coherence tomography

      (Article in Spanish) INTRODUCTION. Pituitary adenomas are a frequently occurring pathology that require multidisciplinary management by several different specialists. Their neuro-ophthalmological manifestations vary widely and sometimes appear as the presenting symptom. AIM. To gather the main ophthalmological signs and symptoms of these tumours so that specialists who find themselves before any of them will suspect this pathology. DEVELOPMENT. This survey was based on the clinical experience of the neuro-ophthalmological unit at the Hospital Clinic de Barcelona, with over 350 patients who had suffered from pituitary tumours. A bibliographical search was also carried out on Medline for papers published on pituitary ...
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    23. Ocular coherence tomography in age-related macular degeneration patients treated with photodynamic therapy with vertepofirin.

      [Article in Portuguese] PURPOSE: To identify the optical coherence tomography (OCT) findings in patients with age-related macular degeneration (ARMD) treated with photodynamic therapy (PDT). STUDY DESIGN: Open, non-randomized, interventional case series. METHODS: ARMD patients were submitted to a complete ophthalmological examination, fluorescein angiography, and OCT at baseline (V0), 3, 6, 9 and 12 months (V3, V6, V9 and V12, respectively). PDT was carried out according to the TAP study. Visual acuity (VA) was measured using the logMAR ETDRS chart. The following foveal measurements were performed: foveal intraretinal thickness (FIRT), foveal choriocapillaris - RPE complex thickness (FCC-RPET) and total foveal thickness (TFT ...
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    24. Optical coherence tomography for macula diagnostics: Review of methods and standardized application concentrating on diagnostic and therapy control of age-related macula degeneration

      (Article in German): Optical coherence tomography (OCT) has gained increasing relevance for follow-up after the treatment of macular diseases especially after anti-VEGF therapy. Therefore it seemed reasonable to develop standardized evaluation strategies and OCT examination guidelines for Stratus OCT III. MATERIALS AND METHODS: Basic guidelines for the Stratus OCT III examination of macular diseases were developed. The first part contains basic advice for the OCT examination with respect to the examiner, patients, image quality, movement artefacts, algorithms, archiving and interpretation of OCT images. The second part consists of the relevance and indications for OCT examination especially in age-related macular degeneration ...
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