Articles from NCBI HomePage

1. Characterization of atherosclerotic plaque in patients with unstable angina pectoris and stable angina pectoris by optical coherence tomography.

   Explore Article NCBI HomePage (Sep 29 2009) Cardiology

   (Article in Chinese) OBJECTIVE: To compare the characterization of coronary atherosclerotic plaques in patients with unstable angina pectoris (UAP) and stable angina pectoris (SAP) by optical coherence tomography (OCT). METHODS: OCT was performed in 47 patients (23 UAP and 24 SAP) undergoing coronary angiography. Lipid-rich plaque (defined by >/= 2 quandrants of the cross-section area), thin cap fibroatheroma (TCFA), thickness of fibrous cap, plaque rupture, calcification and thrombus visualized by OCT were compared between UAP and SAP patients. RESULTS: OCT imaging was successfully in 44 out of 47 patients (22 UAP, 22 SAP). Proportion of lipid-rich plaques was similar between ... (Read Full Article)
   

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2. Variability of optical coherence tomography in assessment of optic disc and retinal nervous fibre layer

   Explore Article NCBI HomePage (Aug 25 2009) Ophthalmology

   (Article in Romanian) PURPOSE: To study the short-term variability of retinal nerve fiber layer (RNFL) and optic disc measurements using Stratus OCT. METHOD: Transversal comparative study with repeated measurements. For each eye, the Fast Optic Disc and Fast RNFL protocols were repeated twice in the same session. The resulted measurements were compared using correlation and variation coefficients. RESULTS: 62 eyes (34 patients) were included in the study. For every analyzed parameter there was a highly significant correlation between the first and the second measurement (p < 0.001). For the C/D ratio (vertical, horizontal and area) the correlation coefficients varied from ... (Read Full Article)
   

   Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec

3. New options of high resolution optical coherence tomography in glaucoma diagnostic.

   Explore Article NCBI HomePage (Aug 5 2009) Ophthalmology

   (Article in German) At present time domain optical coherence tomography (TD-OCT) plays a less important role in glaucoma diagnostics and is used mainly for macula diagnostics. The Fourier domain optical coherence tomography (FD-OCT) with enhanced resolution has new options to detect glaucoma changes. This new technology is referred as frequency domain or spectral domain OCT. This paper will present current and new options of OCT in glaucoma diagnostics. Measurements of the optic nerve head and the retinal nerve fiber layer thickness using this new technology have been shown to be reproducible. Devices which use TD-OCT (e.g. Stratus-OCT) have a lower ... (Read Full Article)
   

   Comment on Article Mentions:   Zeiss Stratus OCT   Optovue RTVue-100   Optovue

4. Sexual dysfunction in men after surgery of colorectal carcinoma. New developments in prevention and therapy

   Explore Article NCBI HomePage (Aug 1 2009) Oncology , Urology

   (Article in Czech) Current procedures in the treatment of rectal carcinoma respect preservation quality of life. Development of sexual dysfunction (SD) in men after iatrogenic damage to neurovascular structures has been reported in 21-38% and significantly decreases quality of life. The author summarizes new developments in the area of surgical anatomy of Denonvilliers' fascia, occurrence of accessory pudendal arteries (APA), and neural anatomy. Introduction of robotic nerve-sparing surgery along with application of new diagnostic perioperative methods such as Doppler diagnostics and Optical Coherence Tomography will allow precise perioperative identification of neurovascular structures. New approaches in the treatment of erectile dysfunction ... (Read Full Article)
   

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5. Retinal nerve fiber layer changes after cataract surgery measured by OCT: a pilot study.

   Explore Article NCBI HomePage (Jul 2 2009) Ophthalmology

   (Article in Spanish) PURPOSE: To analyze changes in peripapillary retinal nerve fiber layer (RNFL) after cataract surgery. METHODS: The average RFNL thickness of patients who underwent cataract surgery was measured using the optical coherence tomography (OCT) III Stratus(R) before surgery, the day after and one month later. The data were analyzed using the SPSS 12.0 software. We used paired two tail student's t test for comparisons. RESULTS: The study group was composed by 74 eyes of 74 patients. The RNFL thickness average was 90.71 microm (SD: 19.93), 88.30 microm (SD: 20.59) and 97.45 microm (SD: 14.30), before cataract surgery (AVGT0), ... (Read Full Article)
   

   Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec

6. Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography

   Explore Article NCBI HomePage (Jun 20 2009) Endoscopy

   PURPOSE: Optical coherence tomography (OCT) is a minimally invasive, depth-resolved imaging tool that can be implemented in a small diameter endoscope for imaging mouse models of colorectal cancer (CRC). In this study, we utilized ultrahigh resolution (UHR) OCT to serially image the lower colon of azoxymethane (AOM) treated A/J mouse models of CRC in order to monitor the progression of neoplastic transformations and determine if OCT is capable of identifying early disease. EXPERIMENTAL DESIGN: Thirteen AOM treated A/J and two control A/J mice were surveyed at four timepoints (8, 14, 22 and 26 weeks post AOM treatment) using a 2.0 ... (Read Full Article)
   

   Comment on Article Mentions:   University of Arizona

7. Optical coherence tomography in diagnosis of urinary bladder cancer

   Explore Article NCBI HomePage (Jun 17 2009) Oncology , Urology

   (Article in Russian) Optical coherence tomography (OCT) was tested in diagnosis of bladder cancer (BC) in 100 BC suspects. This method showed higher sensitivity (by 16%) in diagnosis of BC compared to standard cystoscopy as it more presicely identified squamous intraepithelial and noninvasive tumors. The analysis of OCT images was made with a noval computer program of filtration and color overlay. This improved quality of the image allowed verification or rejection of BC, its localization on urinary bladder wall. PMID: 19526873 [PubMed - in process] (Read Full Article)
   

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8. Choroidal metastasis from a breast carcinoma. Diagnosis and follow-up with optical coherence tomography and fluorescein angiography and autofluorescence with Hra-ii (Heidelberg Retina Angiograph).

   Explore Article NCBI HomePage (May 26 2009) Oncology , Ophthalmology

   Article in Spanish. CLINICAL CASE: A 69-year-old woman developed choroidal metastasis from a breast carcinoma 2 years after the initial diagnosis, surgery and chemotherapy. After treatment with palliative chemotherapy and external radiotherapy, we used fluorescein angiography (FA) and optical coherence tomography (OCT) to evaluate the resolution of the serous retinal detachment, as well as a later relapse in the optic nerve. DISCUSSION: OCT is useful in the follow-up of choroidal metastasis after treatment. However, OCT imaging is limited by the initial choroidal location of metastasis. The autofluorescence can detect exudative tumoral activity even without obvious changes in OCT or FA ... (Read Full Article)
   

   Comment on Article Mentions:   Heidelberg Engineering

9. New concepts in the invasive and non invasive evaluation of remodelling of the right ventricle and pulmonary vasculature in pulmonary arterial hypertension

   Explore Article NCBI HomePage (May 20 2009) Cardiology

   Pulmonary arterial hypertension (PAH) is a rare fatal disease defined as a sustained elevation of pulmonary arterial pressure to more than 25 mmHg at rest, with a mean pulmonary-capillary wedge pressure and left ventricular enddiastolic pressure of less than 15 mmHg at rest. Histopathology of PAH is founded on structural modifications on the vascular wall of small pulmonary arteries characterized by thickening of all its layers. These changes, named as vascular remodelling, include vascular proliferation, fibrosis, and vessel obstruction. In clinical practice the diagnosis of PAH relies on measurements of pulmonary vascular pressure and cardiac output, and calculation of pulmonary ... (Read Full Article)
   

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10. OCT in acute anterior uveitis.

    Explore Article NCBI HomePage (Apr 23 2009) Ophthalmology

    (Article is Spanish). PURPOSE: To evaluate macular thickening, the state of the optic disc and retinal nerve fibers layer (RFNL) in patients with an actual episode of acute anterior uvetis (AAU) by optical coherence tomography (OCT), and compare them with a control group. METHODS: In this prospective, cross-sectional, observational and controlled study we recruited 27 consecutive eyes of 20 patients with an actual episode of AAU, age and sex-matched with 40 healthy eyes of 20 volunteers. The age ranged between 8 and 78 years old, and all were evaluated by the <<fast macular thickness>>, <<fast optic disc>> and <<fast RFNL ... (Read Full Article)
    

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11. Fundus autofluorescence and spectral optical coherence tomography findings in a case with acute posterior multifocal placoid pigment epitheliopathy.

    Explore Article NCBI HomePage (Feb 24 2009) Ophthalmology

    We report fundus autofluorescence and spectral optical coherence tomography (OCT/SLO) findings in acute posterior multifocal placoid pigment epitheliopathy (APMPPE). Different autofluorescence patterns and OCT findings were observed during the acute and resolution phase of the disease. The combined use of new non-invasive technologies may put new insight to the explanation of the histopathology and etiology of APMPPE. PMID: 19230362 [PubMed - in process] (Read Full Article)
    

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12. Update on interventional cardiology

    Explore Article NCBI HomePage (Feb 20 2009) Cardiology

    (Article in Spanish) Percutaneous intervention, whether coronary or noncoronary, continues to be a highly active area of medicine. This article contains an overview of the most notable developments reported in recent months. Drug-eluting stents (DESs) have provided one of the major advances in interventional cardiology as they have very effectively reduced the restenosis rate. Both randomized clinical trials and large observational studies have confirmed their safety, and their use has been extended to include highly complex conditions. Although thrombosis is one complication that can affect both conventional stents and DESs, the rate of late stent thrombosis is slightly, though significantly, ... (Read Full Article)
    

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13. Comparison of Spectral- and Time-Domain OCT in regard of the Automatic Detection of Central Retinal Thickness.

    Explore Article NCBI HomePage (Feb 12 2009) Ophthalmology

    (Article in German) BACKGROUND: The aim of this study was to compare macular thickness measurements obtained from time-domain optical coherence tomography (OCT) and spectral-domain OCT to evaluate their agreement. MATERIALS AND METHODS: Fifty randomly assigned subjects were included. Twenty-five were male, twenty-five female. In all cases both eyes were measured. Serial measurements were obtained from time-domain (StratusOCT, Zeiss) and spectral-domain OCT (Heidelberg Engineering, Germany). Total and regional macular thicknesses were obtained from both machines. Their agreement was estimated by Bland Altman plots. RESULTS: The foveal and total macular thicknesses measured by 3D OCT were significantly greater than those measured by ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Heidelberg Engineering   Carl Zeiss Meditec

14. Pre-neoplastic bronchial lesions: possibilities of diagnosis and chemo-prevention

    Explore Article NCBI HomePage (Feb 4 2009) Bronchoscopy , Oncology

    (Article in Romanian) Early diagnosis of pulmonary cancer is crucial in the fight against this disease. Pre-neoplastic bronchial lesions are the first stage in the evolution towards invasive cancers. This paper describes histological patterns of these pre-neoplastic bronchial lesions, as well as early, intermediate and late molecular disturbancies associated with this condition. The ways to early identification of these lesions are: a) bronchoscopy with laser-induced auto-fluorescence guided through Optical Coherence Tomography, which is able to identify celular and extracelular structures, from the celular surface or beneath it; b) PET-CT which identifies lesions over 6 mm; c) bio-markers: the sensitivity of ... (Read Full Article)
    

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15. Neuro-ophthalmological manifestations of pituitary adenomas. The usefulness of optical coherence tomography

    Explore Article NCBI HomePage (Jan 29 2009) Oncology , Ophthalmology

    (Article in Spanish) INTRODUCTION. Pituitary adenomas are a frequently occurring pathology that require multidisciplinary management by several different specialists. Their neuro-ophthalmological manifestations vary widely and sometimes appear as the presenting symptom. AIM. To gather the main ophthalmological signs and symptoms of these tumours so that specialists who find themselves before any of them will suspect this pathology. DEVELOPMENT. This survey was based on the clinical experience of the neuro-ophthalmological unit at the Hospital Clinic de Barcelona, with over 350 patients who had suffered from pituitary tumours. A bibliographical search was also carried out on Medline for papers published on pituitary ... (Read Full Article)
    

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16. Ocular coherence tomography in age-related macular degeneration patients treated with photodynamic therapy with vertepofirin.

    Explore Article NCBI HomePage (Jan 27 2009) Ophthalmology

    [Article in Portuguese] PURPOSE: To identify the optical coherence tomography (OCT) findings in patients with age-related macular degeneration (ARMD) treated with photodynamic therapy (PDT). STUDY DESIGN: Open, non-randomized, interventional case series. METHODS: ARMD patients were submitted to a complete ophthalmological examination, fluorescein angiography, and OCT at baseline (V0), 3, 6, 9 and 12 months (V3, V6, V9 and V12, respectively). PDT was carried out according to the TAP study. Visual acuity (VA) was measured using the logMAR ETDRS chart. The following foveal measurements were performed: foveal intraretinal thickness (FIRT), foveal choriocapillaris - RPE complex thickness (FCC-RPET) and total foveal thickness ... (Read Full Article)
    

    Comment on Article Mentions:   Universidade Federal de São Paulo

17. Optical coherence tomography for macula diagnostics: Review of methods and standardized application concentrating on diagnostic and therapy control of age-related macula degeneration

    Explore Article NCBI HomePage (Jan 22 2009) Ophthalmology

    (Article in German): Optical coherence tomography (OCT) has gained increasing relevance for follow-up after the treatment of macular diseases especially after anti-VEGF therapy. Therefore it seemed reasonable to develop standardized evaluation strategies and OCT examination guidelines for Stratus OCT III. MATERIALS AND METHODS: Basic guidelines for the Stratus OCT III examination of macular diseases were developed. The first part contains basic advice for the OCT examination with respect to the examiner, patients, image quality, movement artefacts, algorithms, archiving and interpretation of OCT images. The second part consists of the relevance and indications for OCT examination especially in age-related macular degeneration ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Carl Zeiss Meditec

18. Compensation of backscattering coefficient in Fourier-domain optical coherence tomography

    Explore Article NCBI HomePage (Jan 7 2009)

    (Article in Chinese) According to the phenomenon that the intensity of backscattering light decreases dramatically as the detecting depth increases, causing blurred imaging in Fourier-domain optical coherence tomography (FDOCT), a compensation method used for different detecting depth was advanced in the present paper. Through compensating the incident power and scattering coefficient of back-scattered light in each layer of the sample, the real gray level of the image was obtained. With the model of multi-layered homogeneous tissue, the main factors influencing image gray were analyzed. Establishing the FDOCT system with multi-layer cover-glass to be the sample, the structure image was obtained. ... (Read Full Article)
    

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19. Central corneal thickness measurement by optical coherence tomography after Nd: YAG capsulotomy in patients with posterior capsule opacity

    Explore Article NCBI HomePage (Dec 31 2008) Ophthalmology

    PURPOSE: Opacification of the posterior capsule remains the most frequent complication of cataract-intraocular lens surgery. Nd: YAG laser capsulotomy is actually the most common procedure performed to remove the posterior capsule opacification. YAG laser secondary posterior capsulotomy can be associated with significant complications. Possible problems include among others, corneal oedema. Our study has to determine whether the neodymium:yttrium-aluminium-garnet (Nd: YAG) capsulotomy performed in postoperative posterior capsule opacification, has an impact on corneal thickness measured by means of the optical coherence tomography. MATERIAL AND METHODS: 55 patients (43 females and 12 males), who underwent Nd: YAG capsulotomy in posterior capsule opacification, ... (Read Full Article)
    

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20. Optical coherence tomography in benign and malignant melanocytic tumors

    Explore Article NCBI HomePage (Dec 30 2008) Oncology , Ophthalmology

    PURPOSE: To investigate the input of optical coherence tomography (OCT) in evaluation of tissue changes in small choroidal melanocytic lesions. METHODS: We reviewed charts of 20 patients with uveal melanocytic tumors (9 with benign lesions and 11 with malignant ones). The best-corrected visual acuity (BCVA) was of 1.0-0.1 in the benign lesions and of 1.0-0.07 in the malignant ones at the time of presentation. Both fundi were examined after pupil dilatation using an indirect ophthalmoscope and a Goldmann lens.The tumor and the macula were captured and the ultrasound (US) was performed in all patients. Height of the tumor was of ... (Read Full Article)
    

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21. Optical coherence tomography: a reliable tool for localisation of macular hemorrhage. Two case reports.

    Explore Article NCBI HomePage (Dec 25 2008) Ophthalmology

    Recent observations have found that premacular hemorrhage in Valsalva retinopathy is located under the internal limiting membrane. We confirm these findings in two case reports of Valsalva retinopathy. Visual acuity rehabilitation was obtained in the first case by conservative treatment and by draining the hemorrhage into the vitreous with Neodymium (Nd):Yag laser in the second case. We report the current therapeutic guidelines for Valsalva retinopathy, including the systematic search of autosomal dominant syndrome of retinal arterial tortuosity, a rare condition, often discovered after this type of benign macular hemorrhage. PMID: 19107054 [PubMed - in process] (Read Full Article)
    

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22. Anterior segment analysis using OCT3.

    Explore Article NCBI HomePage (Dec 25 2008) Ophthalmology

    PURPOSE: Optical coherence tomography has been used for many years, in particular in the field of the retinal imaging, and is a promising technique in the analysis of the anterior segment, providing a similar resolution to histology for ocular tissue. MATERIAL: and methods: We present a collection of images obtained with the OCT3 (Carl Zeiss Meditec, Dublin, CA), with parameters set to obtain good-quality images of the iris and corneal structures. RESULTS: The OCT provides detailed analysis of the cornea, precise assessment of the dimensions and locations of corneal lesions - in the anterior-posterior plane as well as transversally or ... (Read Full Article)
    

    Comment on Article Mentions:   Carl Zeiss Meditec   Zeiss Cirrus HD-OCT

23. Combined use of optical coherence tomography and intravascular ultrasound during percutaneous coronary intervention in patients with coronary artery disease.

    Explore Article NCBI HomePage (Dec 24 2008) Cardiology

    OBJECTIVE: To evaluate the value of combined optical coherence tomography (OCT) and intravascular ultrasound (IVUS) examinations in detecting coronary artery plaque during percutaneous transluminal coronary intervention (PCI). METHODS: OCT and IVUS examinations were performed on 30 diseased coronary vessels from 27 patients underwent PCI from Feb. 2008 to Jul. 2008. RESULTS: Seventeen vulnerable plaques (4 intima tearing which were not detected by IVUS), 5 plaque rupture (1 out of 5 was detected by IVUS), 5 thrombus lesions (1 out of 5 was found by IVUS), 12 thin-cap lipid-rich lesions (2 detected by IVUS) were detected by OCT in 22 lesions ... (Read Full Article)
    

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24. Current use and future perspectives of diagnostic and therapeutic lasers in oral medicine.

    Explore Article NCBI HomePage (Dec 17 2008) Dentistry

    Several diagnostic and therapeutic methods are based on the optical properties of lasers. In therapeutic applications, laser light is absorbed in a specific manner, whereas light is scattered, reflected, or transmitted from different structures. Improvements in laser technology allow new procedures and broaden the scope of applications for both diagnosis and therapy. The focus of laser application in Oral Medicine diagnosis should be early detection of oral squamous cell carcinoma. Novel modalities for the detection of oral malignancy are urgently needed, while others must be continuously impro-ved. Optical coherence tomography and laser-induced fluorescence spectroscopy are currently being studied. In addition ... (Read Full Article)
    

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