Articles from Journal of Applied Physiology

1. Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function

   Explore Article Journal of Applied Physiology (Nov 13 2009) Bronchoscopy

   Regulation of airway caliber by lung volume or bronchoconstrictor stimulation is dependent on physiological, structural and mechanical events within the airway wall, including airway smooth muscle (ASM) contraction, deformation of the mucosa and cartilage, and tensioning of elastic matrices linking wall components. Despite close association between events in the airway wall and the resulting airway caliber these have typically been studied separately: the former primarily using histological approaches, the latter with a range of imaging modalities. We describe a new optical technique, anatomical optical coherence tomography (aOCT), which allows changes at the luminal surface (airway caliber) to be temporally related ... (Read Full Article)
   

   Comment on Article Mentions:   Julian J. Armstrong   David D. Sampson   University of Western Australia

2. Three-dimensional measurement of alveolar airspace volumes in normal and emphysematous lungs using micro-CT

   Explore Article Journal of Applied Physiology (Aug 1 2009) Bronchoscopy

   In pulmonary emphysema, the alveolar structure progressively breaks down via a three-dimensional (3D) process that leads to airspace enlargement. The characterization of such structural changes has, however, been based on measurements from two-dimensional (2D) tissue sections or estimates of 3D structure from 2D measurements. In this study, we developed a novel silver staining method for visualizing tissue structure in 3D using micro-computed tomographic (CT) imaging, which showed that at 30 cmH20 fixing pressure, the mean alveolar airspace volume increased from 0.12 nl in normal mice to 0.44 nl and 2.14 nl in emphysematous mice, respectively, at 7 and 14 days ... (Read Full Article)
   

   Comment on Article Mentions:   Boston University

1-2 of 2