1. 1-9 of 9
    1. Optical coherence tomography (OCT) in patients with acute respiratory failure on the ICU

      Optical coherence tomography (OCT) in patients with acute respiratory failure on the ICU

      Introduction: Differentiating ARDS from other forms of respiratory failure can be difficult. By advancing an optic fiber through a diagnostic bronchoscope, followed by an automatic pullback mechanism, OCT enables real-time 3D imaging of the alveolar compartment and peripheral airways. Aim: To investigate feasibility of bronchoscopic OCT, and to describe different OCT patterns of the alveolar compartment in mechanically ventilated patients. Methods: Observational study of OCT imaging in mechanically ventilated patients for non-resolving acute respiratory failure with an indication for diagnostic bronchoscopy. Results: 9 patients were included with clinical features of acute respiratory failure and bilateral pulmonary infiltrates not fully explained ...

      Read Full Article
    2. Small airway dilation visualized by optical coherence tomography (OCT) correlates with the diagnosis of chronic lung allograft dysfunction (CLAD)

      Small airway dilation visualized by optical coherence tomography (OCT) correlates with the diagnosis of chronic lung allograft dysfunction (CLAD)

      Background: Small airways and the surrounding tissue of the lung allograft are often affected by pathological processes including acute cellular rejection (ACR), infections and different phenotypes of CLAD. OCT with superior resolution but shallow penetration, allows the visualization of these structures in contrast to routine radiographic imaging. Methods: We studied 54 lung transplant (LTx) recipients with OCT imaging during surveillance (n=36) or event (n=19) bronchoscopies. Volumetric images of 3 segmental airways were collected from each patient. OCT features were scored by 4 raters blinded to the clinical status of LTx recipients. Pearson correlation coefficients (R) were used to ...

      Read Full Article
    3. Optical coherence tomography (OCT) detects collagen within the airway wall extracellular matrix

      Optical coherence tomography (OCT) detects collagen within the airway wall extracellular matrix

      Introduction: Airway diseases are characterized by structural airway remodeling, including extracellular matrix (ECM) changes. Although a key feature, no diagnostic test currently assesses airway remodeling other than invasive airway biopsies. Real-time optical coherence tomography (OCT) generates infrared-based cross-sectional images of airway segments. Previously we reported that OCT identifies and quantifies airway wall layers. We hypothesized that OCT is able to detect collagen deposition areas within the airway wall ECM. Methods: In 5 lobectomy specimens 13 airways were dissected, marked with needles for matching histology and imaged by OCT. Sections were stained for total collagen (TC; pico sirius red) and collagen ...

      Read Full Article
    4. Excess mucus viscosity and airway dehydration impact COPD airway clearance

      Excess mucus viscosity and airway dehydration impact COPD airway clearance

      The mechanisms by which cigarette smoking impairs airway mucus clearance are not well understood. We recently established a ferret model of cigarette smoke-induced chronic obstructive pulmonary disease (COPD) exhibiting chronic bronchitis. We investigated the effects of cigarette smoke on mucociliary transport (MCT). Adult ferrets were exposed to cigarette smoke for 6 months, with in vivo mucociliary clearance (MCC) measured by Tc-labeled DTPA (Tc-DTPA) retention. Excised tracheae were imaged with micro-optical coherence tomography. Mucus changes in primary human airway epithelial cells and ex vivo ferret airways were assessed by histology and particle tracking microrheology. Linear mixed models for repeated measures identified ...

      Read Full Article
    5. Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT)

      Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT)

      Background: Bronchial Thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with thermal energy. The extent of treatment effect is largely unknown. Optical coherence tomography (OCT) is a high resolution imaging technique, using near-infrared light, that generates near-histology cross sectional images of the airway wall. Aim: Assess the extent of acute airway wall effects of BT with OCT and compare these to the untreated right middle lobe (RML). Methods: 15 severe asthma patients were treated with BT. During the third procedure, OCT imaging was performed in BT treated (sub)segmental airways in the upper lobes ...

      Read Full Article
    6. Optical coherence tomography in the diagnosis of sarcoidosis of lung and other organs

      Optical coherence tomography in the diagnosis of sarcoidosis of lung and other organs

      Sarcoidosis is a disease involving abnormal collections of inflammatory cells that form lumps known as granulomas. The disease can affect the lungs, skin, lymph nodes, eyes, liver, heart, and brain. As for the eyes it occupies 3-4 place among organs-target. Diagnosis of eye sarcoidosis is quite complicated and is usually found in ophthalmologic examination. Objective: Studying of diagnostic significance of additional methods of ophthalmology examination for sarcoidosis of lung and other localizations. Methods: It was a prospective investigation. The study group consisted of patients with the first identified sarcoidosis in different organs. The control group consisted of patients with tuberculosis ...

      Read Full Article
      Mentions: Optovue
    7. Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography

      Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography

      Bronchial thermoplasty (BT) is a novel, nonpharmacological procedure for treatment of severe asthma. Recently, the Asthma Intervention Research 2 clinical trial demonstrated asthmatics had fewer hospitalisations following BT, which persisted 5 years after therapy [1]. However, it is well recognised that asthma is a heterogeneous disease with distinct asthma phenotypes and, not surprisingly, not all asthmatics in that trial benefited from BT [2].

      Read Full Article
    8. Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques

      The ability to measure airway dimensions is important for clinicians, interventional bronchoscopists and researchers in order to accurately quantify structural abnormalities and track their changes over time or in response to treatment. Most quantitative airway measurements are based on X-ray computed tomography and, more recently, on multidetector computed tomography. Quantitative bronchoscopic techniques have also been developed, although these are less widely employed. Emerging techniques, including magnetic resonance imaging, endoscopic optical coherence tomography, endobronchial ultrasound and confocal endomicroscopy, provide new research tools with potential clinical applications. An understanding of issues related to the acquisition, processing and analysis of images, and how ...
      Read Full Article
    9. Measuring airway dimensions during bronchoscopy using anatomical optical coherence tomography

      Airway dimensions are difficult to quantify bronchoscopically because of optical distortion and a limited ability to gauge depth. Anatomical optical coherence tomography (aOCT), a novel imaging technique, may overcome these limitations. This study evaluated the accuracy of aOCT against existing techniques in phantom, excised pig and in vivo human airways. Three comparative studies were performed: (i) micrometer-derived area measurements in ten plastic tubes were compared to aOCT-derived area; (ii) aOCT-derived airway compliance curves from excised pig airways were compared to curves derived using an endoscopic technique; and (iii) airway dimensions from the trachea to subsegmental bronchi were measured using aOCT ...

      Read Full Article
    1-9 of 9
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks