1. 1-26 of 26
    1. Glaucomatous retinal nerve fibre layer defects may be identified in Stratus OCT images classified as normal

      Acta Ophthalmologica, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Abstract.Purpose: We aimed to compare the retinal nerve fibre layer (RNFL) in different Stratus optical coherence tomography (OCT) images in glaucoma eyes with RNFL thickness values within normal limits.Methods: We studied the Stratus OCT high-resolution ...
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    2. Evaluation of pharyngeal shape and size using anatomical optical coherence tomography in individuals with and without obstructive sleep apnoea

      Journal of Sleep Research, Volume 17, Issue 2, Page 230-238, June 2008. SummaryThis study compared shape, size and length of the pharyngeal airway in individuals with and without obstructive sleep apnoea (OSA) using a novel endoscopic imaging technique, anatomical optical coherence tomography (aOCT). The study population ...
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    3. Machine-learning classification of non-melanoma skin cancers from image features obtained by optical coherence tomography

      Background/purpose: A number of publications have suggested that optical coherence tomography (OCT) has the potential for non-invasive diagnosis of skin cancer. Currently, individual diagnostic features do not appear sufficiently discriminatory. The combined use of several features may however be useful. Methods: OCT is based on infrared light, photonics and fibre optics. The system used has an axial resolution of 10 μm, lateral 20 μm. We investigated the combined use of several OCT features from basal cell carcinomas (BCC) and actinic keratosis (AK). We studied BCC (41) and AK (37) lesions in 34 consecutive patients. The diagnostic accuracy of the ...
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    4. Detailed comparison between endocytoscopy and horizontal histology of an esophageal intraepithelial squamous cell carcinoma

      SUMMARY. Endocytoscopy allows the real-time microscopic observation of living cells. Unlike the cross-sectional images obtained by conventional histology, endocytoscopy provides cellular images in a plane parallel to the surface of the mucosa. However, there is little knowledge about the endocytoscopic diagnosis of carcinomas. Using a specimen obtained by the endoscopic submucosal dissection of an intraepithelial esophageal squamous cell carcinoma, a detailed comparison between endocytoscopic and horizontal histological images was made, revealing the similarity between the images. Sharp lateral borders between atypical and normal epithelium and differences in cellularity and the sizes and shapes of the nuclei were clearly identified by ...
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    5. In vivo reflectance-mode confocal microscopy in clinical dermatology and cosmetology

      In vivo reflectance confocal microscopy (RCM) is a non-invasive imaging tool that allows real-time visualization of cells and structures in living skin with near histological resolution. RCM has been used for the assessment of benign and malignant lesions, showing great potential for applications in basic skin research and clinical dermatology. RCM also reveals dynamic changes in the skin over time and in response to specific stimuli, like ultraviolet exposure, which makes it a promising tool in cosmetology, as it allows repetitive sampling without biopsy collection, causing no further damage to the areas under investigation. This review summarizes the latest advances ...
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    6. Magnification characteristics of the Optical Coherence Tomograph STRATUS OCT 3000

      Purpose: To evaluate the magnification characteristics of an Optical Coherence Tomograph (STRATUS OCT 3000) used to measure optic disc size.Methods: An eye model was designed, built and used to measure changes in the magnification of the Optical Coherence Tomograph (OCT) with variation in the axial length of the eye and OCT correction lenses. Theoretical calculations using ray-tracing were used to compare the experimental and theoretical results.Results: OCT-performed fundus measurements have a magnification that depends on two factors: eye axial length and optical correction with the focusing dial of the OCT. Theoretical calculations showed that the size of the ...

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    7. Application of optical coherence tomography in non-invasive characterization of skin vascular lesions

      Optical coherence tomography (OCT) is a new non-invasive approach for real-time in vivo tissue characterization. A promising use of OCT can be the assessment of the architecture of lesions with some degree of inhomogeneities, such as vascular lesions. Knowledge of the size and depth of the vascular structures can be useful for the diagnosis and for choosing the best treatment.
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    8. Correlation between intraretinal changes in diabetic macular oedema seen in fluorescein angiography and optical coherence tomography

      Abstract.Purpose: To study the relationship between intraretinal optical coherence tomography (OCT) and fluorescein angiography (FA) findings in eyes with diabetic macular oedema (DMO).Methods: We carried out a retrospective observational case series. ...

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    9. A device for the color measurement and detection of spots on the skin

      Background/purpose: In this work, we present a new and fast easy-to-use device that allows the measurement of color and the detection of spots on the human skin. The developed device is highly practical for relatively untrained operators and uses inexpensive consumer equipment, such as a CCD color camera, a light source composed of LEDs and a laptop. The knowledge of the color of the skin and the detection of spots can be useful in several areas such as in dermatology applications, the cosmetics industry, the biometrics field, health care, etc. Methods: In order to perform these measurements the system ...
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    10. Optical Coherence Tomography: A Noninvasive Method to Assess Wound Reepithelialization

      Background Accurate assessment of wound healing may require invasive tissue biopsies, limiting its clinical usefulness in humans. Optical coherence tomography (OCT) is a novel, high-resolution method using light reflection to obtain noninvasive cross sectional imaging of biological tissues. ObjectivesTo evaluate the utility of OCT for assessing wound reepithelialization in a porcine model. MethodsThe authors conducted an animal study with two domestic pigs. Excisional cutaneous wounds were created over the ventral surface of the animals using an electric dermatome set at a depth of 600 μm. The wounds were excised two or three days later and precisely marked to guide initial ...
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    11. Correlation between retinal nerve fibre layer thickness and retinal sensitivity

      Purpose: To evaluate the relationship between retinal nerve fibre layer (RNFL) thickness measured by optical coherence tomography (OCT) and light threshold values obtained with the Micro Perimeter 1 (MP1). Methods: Forty-nine normal subjects and 37 glaucoma patients were included. Thickness of the RNFL around the optic disc was measured with Stratus OCT scans, and static threshold perimetry was performed with the MP1 at the same visit. Total average and mean 12-clock-hour RNFL thickness were measured with Stratus OCT. An automated 4-2-1 staircase strategy with Goldmann III stimuli was used for MP1. The correspondence between Stratus OCT and MP1 RNFL measurements ...
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    12. Pilot study on the correlation of optical coherence tomography with histology in celiac disease and normal subjects

      Background and Aim: Celiac disease (CD) is a common condition but often it goes unrecognized because characteristic histopathological abnormalities must be found to confirm the diagnosis. A way is needed to select patients who need biopsy of the duodenal mucosa to detect CD. No data are currently available on the use of in vivo optical coherence tomography (OCT), during real-time endoscopic imaging, in the small intestine and, particularly, in the diagnosis of CD. The aim of the present study was to test the utility of OCT in patients undergoing esophagogastroduodenoscopy (EGD) for histological diagnosis. Methods: Eighteen patients with suspected CD ...

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    13. Optical coherence tomography and vessel diameter changes after intravitreal bevacizumab in diabetic macular oedema

      Purpose: To assess the effect of intravitreal bevacizumab on diabetic macular oedema (DMO) and retinal vessel calibres. Methods: We performed a consecutive case series study in which 10 consecutive eyes with diffuse DMO, two of which had not previously been treated, received an intravitreal injection of bevacizumab 1 mg, which was followed by two more injections at 6-week intervals. Fundus photography and optical coherence tomography (OCT) were carried out at baseline immediately before injection and at 1, 2.5 and 4 months after the first injection. Outcome measures were best corrected visual acuity (BCVA) in Early Treatment Diabetic Retinopathy Study ...

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    14. The predictive value of optical coherence tomography after grid laser photocoagulation for diffuse diabetic macular oedema

      Purpose: To assess the predictive value of optical coherence tomography (OCT) mapping of retinal thickness and intraretinal morphological changes after macular grid for diffuse diabetic macular oedema (DMO). Methods: We carried out a prospective, non-controlled, case series study, in which 28 consecutive eyes with previously untreated diffuse DMO underwent fundus photography and OCT at baseline and at 1, 3 and 6 months after treatment. Results: Macular photocoagulation was followed by a significant reduction in retinal thickness in the foveal centre (− 80 μm) and in the foveal subfield (− 65 μm) from baseline to 6 months (p 0.05). The relative decrease ...

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    15. Nail thickness measurements using optical coherence tomography and 20-MHz ultrasonography

      Background Nail diseases are often troubling to the patient and may present a diagnostic challenge to the dermatologist. Biopsies from the nail may be required although often perceived uncomfortable by the patient and potentially scarring. Noninvasive technologies are therefore of particular interest in the study of nails. Optical coherence tomography (OCT) is an optical imaging modality which may provide improved data. Objectives This study evaluates nail morphology and thickness in OCT images in comparison with high-frequency ultrasound (HFUS) imaging of the nail. Methods Ten healthy volunteers were recruited for imaging and nail measurements; OCT and HFUS images were compared qualitatively ...
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    16. Imaging of intradermal tattoos by optical coherence tomography

      Background/purpose: Tattoos have become increasingly popular followed by a growing demand for tattoo removal, and yet there is little knowledge and monitoring of tattoo pigment deposition in skin layers. The purpose of this pilot study is to describe optical coherence tomography image characteristics of intradermal tattoos. Methods: We included five black tattoos in 3 female volunteers, 39, 35 and 30 years old. In vivo imaging of tattoo pigments in the skin is possible with optical coherence tomography (OCT), a novel non-invasive, in vivo optical imaging technology with a resolution and a penetration in skin high enough for visualization of ...
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    17. Polypoidal choroidal vasculopathy examined with en face optical coherence tomography

      Background: To study the morphologic features of polypoidal choroidal vasculopathy (PCV) with the use of en face optical coherence tomography (OCT). Methods: We reviewed retrospectively 57 eyes of 57 patients with PCV. The macular region was examined with OCT en face planes scanned at different sequential depths, following which detailed scanning was performed of arbitrarily selected longitudinal planes. Results: In 48 of the cases (84.2%), en face OCT allowed us to detect round protrusions of the retinal pigment epithelium (RPE) that corresponded to the polypoidal lesions seen on indocyanine green angiography (ICGA); the branching vascular networks seen on ICGA ...
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    18. Enhanced optical coherence patterns of diabetic macular oedema and their correlation with the pathophysiology

      Enhanced optical coherence patterns of diabetic macular oedema and their correlation with the pathophysiology
      Purpose: To describe different patterns of diabetic macular oedema (DMO) using a computerized alignment and averaging of sequences in optical coherence tomography (OCT) B-scans and to show the correlation of these patterns with the pathophysiology of the condition. Methods: We carried out a prospective, uncontrolled study, including 46 human subjects with untreated DMO. Enhanced OCT images were produced. We correlated different OCT patterns of DMO with ETDRS visual acuity and with the thickness of the central 1-mm of the macula. We also correlated these patterns with theories of the pathophysiology of DMO. Results: Enhanced OCT images enabled us to examine ...
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    19. Technical Note: Method for estimating volume of subretinal fluid in cases of localized retinal detachment by OCT ophthalmoscopy

      The volume of the subretinal fluid can be used to assess the condition of different types of retinal and macular disorders. The purpose of this report is to introduce a method to measure the volume of the subretinal fluid with the images of the optical coherence tomography (OCT) Ophthalmoscope in three cases of central serous chorioretinopathy and one case of retinal pigment epithelial detachment. We used the topography-mode program of the OCT Ophthalmoscope and measured the average height of the retinal detachment. By multiplying the size of the area of the retinal detachment and the average height of the retinal ...
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    20. Clinical applications and new developments of optical coherence tomography: an evidence-based review

      Optical coherence tomography (OCT) is a new imaging modality that has increasingly become an indispensable tool in clinical practice for the diagnosis and management of ocular diseases involving the macula, optic nerve and anterior segment. The instrument is an advanced imaging technique that provides unprecedented high resolution and cross-sectional tomographic images of the ocular microstructure in situ, and in real time. Since its introduction about four years ago, a multitude of advantages has made OCT an essential instrument in ophthalmic imaging. The technique has fast image acquisition speed and non-contact, non-invasive applicability, allowing a non-excisional ‘optical biopsy’ to be performed ...
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    21. Optical coherence tomography in anterior segment imaging

      Purpose: To evaluate the ability of optical coherence tomography (OCT), designed primarily to image the posterior segment, to visualize the anterior chamber angle (ACA) in patients with different angle configurations. Methods: In a prospective observational study, the anterior segments of 26 eyes of 26 patients were imaged using the Zeiss Stratus OCT, model 3000. Imaging of the anterior segment was achieved by adjusting the focusing control on the Stratus OCT. A total of 16 patients had abnormal angle configurations including narrow or closed angles and plateau irides, and 10 had normal angle configurations as determined by prior full ophthalmic examination ...
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    22. Optical coherence tomography evidence of rapid progression from vitreomacular traction to full thickness macular hole

      The authors present a case of a patient with idiopathic vitreomacular traction who subsequently developed a full thickness macular hole 3 weeks following the onset of metamorphopsia. Vitreomacular traction is a well described phenomenon and has been known to resolve spontaneously and in this patient the conservative approach was adopted initially. However, she progressed rapidly to a full thickness macular hole and therefore, the authors recommend close monitoring of such patients with a view to early vitrectomy to prevent progressive morbidity.
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    23. Glaucoma detection using different Stratus optical coherence tomography protocols

      Purpose: To examine and compare the diagnostic accuracy of retinal nerve fibre layer (RNFL) thickness measurements using different Stratus optical coherence tomography (OCT) scanning protocols. Methods: Stratus OCT data for 90 healthy subjects and 62 glaucoma patients with mild or moderate visual field loss were prospectively collected and analysed using four RNFL thickness protocols that differed in terms of image resolution and number of scans. Cut-off levels corrected for age and refractive error were defined by reference values derived from an independent normal database. Sensitivity and specificity were calculated for average RNFL thickness for the full circle scan, and for ...
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    24. Optical coherence tomography of chorioretinal and choroidal folds

      Purpose: To report the optical coherence tomography (OCT) findings in cases of chorioretinal and choroidal folds. Methods: Eight subjects with folds of the fundus of the eye were examined with fundus photography, fluorescein angiography, B-scan ultrasonography and Stratus OCT. Results: Two types patterns were found on OCT. Five cases showed undulating retinal as well as retinal pigment epithelial lines of normal thickness; these were defined as chorioretinal folds. The posterior vitreous surface often adhered to the crests of the folds only. Three cases exhibited a wavy appearance of the retinal pigment epithelium and a flat retinal surface; these were classified ...
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    25. Assessment of the posterior segment of the cat eye by optical coherence tomography (oct)

      Objectives To assess the feasibility of optical coherence tomography (OCT) for examining the cat ocular fundus, to provide normative data on retinal thickness in different fundus regions, and to demonstrate selected surgically induced vitreoretinal pathologies in the cat. Animal studied Forty-five eyes of 28 healthy domestic cats and two eyes of domestic cats that had undergone subretinal implantation surgery for a visual prosthesis were examined. Procedures An optical coherence tomograph (Zeiss-Humphrey) was used to examine the anesthetized animals. At least five vertical and five horizontal scans in regular distribution were recorded for each cat including (1) the peripapillary region, (2 ...
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