About William R. Freeman

William R. Freeman

William R. Freeman, M.D. is an internationally acclaimed scientific researcher and Director of the Jacobs Retina Research Center, adjoining the UCSD Shiley Eye Center. The clinical research center at the Jacobs Center will enable patients to benefit from the latest advances in diagnostic equipment and therapies. Researchers working in the Center's laboratories will focus on advancing promising therapies for macular degeneration, tumors, inherited retinal disease, retinal detachment, macular holes, and other important retinal diseases. Dr. Freeman is Professor of Ophthalmology at UCSD and has built a clinical and research enterprise of excellence since he came to UCSD in 1986. The new Jacobs Retina Center has allowed him to continue to build a research team dedicated to attacking retinal diseases that cause blindness and vision loss.

  1. Mentioned In 16 Articles

  2. Dynamics of the Macular Hole-Silicone Oil Tamponade Interface With Patient Positioning As Imaged By Spectral Domain-Optical Coherence Tomography

    Explore Article LWW Online (May 14 2010)

    Dynamics of the Macular Hole-Silicone Oil Tamponade Interface With Patient Positioning As Imaged By Spectral Domain-Optical Coherence Tomography Purpose: The purposes of this study were to evaluate with spectral domain-optical coherence tomography the relationship between the retina and overlying silicone oil tamponade after macular hole surgery and to evaluate how this relationship changes with patient positioning. Methods: We studied a retrospective consecutive case series of 10 eyes from 9 patients who underwent macular hole surgery with silicone oil tamponade and subsequent spectral domain-optical coherence tomography scans. Four of ... (Read Full Article)

    Comment on Article Mentions:   UCSD   Francesca Mojana   William R. Freeman

  3. Correlation Between Morphologic Features on Spectral-Domain Optical Coherence Tomography and Angiographic Leakage Patterns in Macular Edema

    Explore Article LWW Online (Mar 11 2010)

    Purpose: The purpose of this study was to determine the morphologic patterns of angiographic macular edema using simultaneous colocalization of fluorescein angiography and spectral-domain optical coherence tomography (SD-OCT) images in diabetes, epiretinal membrane, uveitic and pseudophakic cystoid macular edema, and vein occlusion. Methods: Eighty-seven consecutive patients (107 eyes) with macular edema from 5 different etiologies were imaged by simultaneous scanning laser ophthalmoscopy/OCT to study the morphologic patterns of edema on ... (Read Full Article)

    Comment on Article Mentions:   UCSD   Francesca Mojana   Igor Kozak

  4. Observations by Spectral-Domain Optical Coherence Tomography Combined with Simultaneous Scanning Laser Ophthalmoscopy: Imaging of the Vitreous

    Explore Article American Journal of Ophthalmology (Feb 7 2010)

    ...eoretinal interface, and it is particularly useful for defining focal changes and PVD. Inquiries to William R. Freeman, Department of Ophthalmology, Shiley Eye Center, 0946, University of California, San Diego, Joan an... (Read Full Article)

    Comment on Article Mentions:   William R. Freeman   UCSD   Francesca Mojana

  5. Disruption of the Photoreceptor Inner Segment/Outer Segment Layer on Spectral Domain-Optical Coherence Tomography Is A Predictor of Poor Visual Acuity in Patients With Epiretinal Membranes

    Explore Article LWW Online (Jan 4 2010)

    Purpose: The purpose of this study was to evaluate the predictive value of spectral domain-optical coherence tomography-determined integrity of the photoreceptor inner segment/outer segment (IS/OS) junction on visual acuity in patients with epiretinal membranes (ERMs). Methods: This is a retrospective consecutive case series of 54 eyes from 48 patients with primary ERMs who underwent spectral domain-optical coherence tomography scans. Regression analysis was used to calculate the relative contribution of several ... (Read Full Article)

    Comment on Article Mentions:   UCSD   Francesca Mojana   William R. Freeman

  6. Optical Coherence Tomography-Raster Scanning and Manual Segmentation in Determining Drusen Volume in Age-Related Macular Degeneration

    Explore Article LWW Online (Dec 3 2009)

    Purpose: Drusen are the hallmark of age-related macular degeneration (AMD), and substantial evidence exists that the amount of drusen and their effect on retinal pigment epithelium is a strong predictor of progression of AMD and vision loss. Until recently, it was not possible to quantitate the volume of the drusen. However, the use of image-stabilized scanning laser ophthalmoscope or spectral domain-optical coherence tomography (OCT) has enabled determination of drusen volume ... (Read Full Article)

    Comment on Article Mentions:   UCSD   William R. Freeman   Francesca Mojana

  7. Comparison of A Novel Confocal Scanning Laser Ophthalmoscopy Algorithm With Optical Coherence Tomography in Measurement of Macular Thickness and Volume

    Explore Article LWW Online (Nov 26 2009)

    Purpose: To evaluate macular thickness and volume measurements using a novel Heidelberg Retinal Tomograph (HRT3) algorithm and to compare the results with optical coherence tomography (StratusOCT). Methods: This was a prospective, comparative, clinical noninterventional study. Fifty-two eyes were examined using both methods: 16 normal eyes, 12 eyes with diabetic macular edema (DME), and 24 eyes with age-related macular degeneration (AMD). The HRT3 macular thickness and volume were compared with those ... (Read Full Article)

    Comment on Article Mentions:   Heidelberg Engineering   Carl Zeiss Meditec   UCSD

  8. Spectral Domain Optical Coherence Tomography for Imaging Erm, Retinal Edema, and Vitreomacular Interface

    Explore Article LWW Online (Nov 26 2009)

    Purpose: To evaluate images taken with OTI-OPKO spectral domain optical coherence tomography (OCT)/scanning laser ophthalmoscope (resolution of 5-8 [mu]m) and compare them with conventional StratusOCT in eyes with epiretinal membranes (ERMs), macular edema, and vitreoretinal interface abnormalities. Methods: We evaluated 79 consecutive eyes with retinal pathologies using Spectral OCT/scanning laser ophthalmoscope (OTI-OPKO Health Inc, Miami, FL) and StratusOCT (Carl Zeiss Meditec Inc, Dublin, CA) at the Jacobs Retina Center, University ... (Read Full Article)

    Comment on Article Mentions:   OTI Ophthalmic Technologies Inc.   Carl Zeiss Meditec   UCSD

  9. Correlation between Spectral-Domain Optical Coherence Tomography and Fundus Autofluorescence at the Margins of Geographic Atrophy

    Explore Article American Journal of Ophthalmology (Jun 21 2009)

    Purpose: To study the appearance of margins of geographic atrophy in high-resolution optical coherence tomography (OCT) images and to correlate those changes with fundus autofluorescence (FAF) imaging.Design: Retrospective, observational case study.Methods: Patients with geographic atrophy secondary to dry age-related macular degeneration were assessed by means of spectral-domain OCT (Spectralis Heidelberg Retinal Angiograph/OCT; Heidelberg Engineering, Heidelberg, Germany; or OTI Inc, Toronto, Canada) as well as autofluorescence imaging (Heidelberg Retinal Angiograph or ... (Read Full Article)

    Comment on Article Mentions:   Heidelberg Spectralis   Heidelberg Engineering   UCSD

  10. Colour versus grey-scale display of images on high-resolution spectral OCT

    Explore Article BJO Online (Apr 23 2009)

    Aim: To determine whether colour or grey-scale images from high-resolution spectral optical coherence tomography (OCT) are superior in visualising clinically important details of retinal structures. Methods: Patients with macular pathologies were imaged using spectral OCT (OTI, Toronto, Canada). Two reviewers independently analysed the retinal structures and pathologies and graded them on a four-point scale on the basis of the visibility. A third reviewer masked to the results then reviewed images ... (Read Full Article)

    Comment on Article Mentions:   UCSD   William R. Freeman   Francesca Mojana

  11. Imaging vitreomacular interface abnormalities in the coronal plane by simultaneous combined scanning laser and optical coherence tomography

    Explore Article BJO Online (Feb 23 2009)

    Aim: To describe vitreoretinal imaging of eyes with vitreomacular abnormalities using high-resolution coronal-plane optical coherence tomography (OCT) scanning combined with simultaneous scanning laser ophthalmoscope (SLO) imaging. Methods: A SLO–OCT (OTI, Canada) was used to scan 835 eyes in 736 patients with vitreomacular interface abnormalities including epiretinal membranes, macular hole, incomplete posterior vitreous detachment, vitreomacular traction syndromes and diabetic and cystoid macular oedema in a retrospective study. The longitudinal-B scan images ... (Read Full Article)

    Comment on Article Mentions:   New York Eye and Ear Infirmary   UCSD   OTI Ophthalmic Technologies Inc.

  12. Visualization of Retinal Emboli With High-Resolution Optical Coherence Tomography

    Explore Article Archives of Ophthalmology (Feb 8 2009)

    ... With High-Resolution Optical Coherence Tomography Stephen F. Oster, MD, PhD; Francesca Mojana, MD; William R. Freeman, MD Arch Ophthalmol. 2009;127(2):218. Since this article does not have an abstract, we have provide... (Read Full Article)

    Comment on Article Mentions:   William R. Freeman   Francesca Mojana   UCSD

  13. Imaging Vitreo-Macular Interface Abnormalities In The Coronal Plane By Simultaneous Combined Scanning Laser And Optical Coherence Tomography

    Explore Article BJO Online (Nov 18 2008)

    ...Uwe G Bartsch ^1^*, Igor Kozak ^1, Richard Rosen ^2, Iryna A Falkenstein ^1, Patricia Garcia ^2 and William R. Freeman ^1 ^1 University of California San Diego, United States ^2 NYEEI, United States ^* To whom correspo... (Read Full Article)

    Comment on Article Mentions:   Igor Kozak   William R. Freeman   Richard B. Rosen

  14. The Role of Abnormal Vitreomacular Adhesion in Age-related Macular Degeneration: Spectral Optical Coherence Tomography and Surgical Results

    Explore Article American Journal of Ophthalmology (Jul 31 2008)

    Purpose: To assess the incidence of vitreomacular adhesion and traction in age-related macular degeneration (AMD), and to evaluate surgical treatment in a subset of patients with choroidal neovascularization (CNV) nonresponsive to anti-neovascular growth factor (anti-VEGF) treatment.Design: Retrospective observational case-control and interventional case series.Methods: Spectral optical coherence tomography, combined with simultaneous scanning laser ophthalmoscope (Spectral OCT/SLO), was performed in 170 eyes of 94 elderly patients, 61 with exudative AMD, 59 with ... (Read Full Article)

    Comment on Article Mentions:   UCSD   OTI Ophthalmic Technologies Inc.   Ophthalmic Technologies Spectral OCT/SLO

  15. The Role of Abnormal Vitreomacular Adhesion in Age-related Macular Degeneration: Spectral Optical Coherence Tomography and Surgical Results

    Explore Article ScienceDirect (Jun 11 2008)

    Purpose: To assess the incidence of vitreomacular adhesion and traction in age-related macular degeneration (AMD), and to evaluate surgical treatment in a subset of patients with choroidal neovascularization (CNV) nonresponsive to anti-neovascular growth factor (anti-VEGF) treatment.Design: Retrospective observational case-control and interventional case series.Methods: Spectral optical coherence tomography, combined with simultaneous scanning laser ophthalmoscope (Spectral OCT/SLO), was performed in 170 eyes of 94 elderly patients, 61 with exudative AMD, 59 with ... (Read Full Article)

    Comment on Article Mentions:   William R. Freeman   UCSD   Francesca Mojana

  16. Use Of Coronal Simultaneous Optical Coherence Tomography/Scanning Laser Ophthalmoscopy To Demonstrate Cystoid Macular Edema Secondary To Extrafoveal Retinal Hole.

    Explore Article RETINAL Cases & Brief Reports (Apr 8 2008)

    The authors recently were referred a patient with cystoid macular edema (CME) distal to such a postoperative extrafoveal break after ERM removal. The authors used a novel imaging technology of combined scanning laser ophthalmoscope (SLO)/optical coherence tomography (OCT) for coronal (en-face) imaging of this pathologic finding.Page: 91DOI: 10.1097/IAE.0b013e31802be740Authors: Kozak, Igor MD; Bartsch, Dirk-Uwe PhD; Freeman, William R. MD (Read Full Article)

    Comment on Article Mentions:   William R. Freeman   UCSD   Dirk-Uwe G. Bartsch

  17. Discrepancy Between Fluorescein Angiography And Optical Coherence Tomography In Detection Of Macular Disease.

    Explore Article RETINA (Apr 8 2008)

    Purpose: To compare high-resolution optical coherence tomography (OCT) and fluorescein angiography (FA) in detection of macular edema (ME) of various etiologies. Methods: In a retrospective study over a 12-month period at one retina center, data for consecutive eyes that had undergone simultaneous conventional FA (HRA; Heidelberg Engineering, Vista, CA) and StratusOCT (Carl Zeiss Meditec, Dublin, CA) to rule out ME were reviewed. A subset of patients underwent additional examination with ... (Read Full Article)

    Comment on Article Mentions:   Heidelberg Engineering   Iryna Falkenstein   Carl Zeiss Meditec

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