Stephen A. Boppart

About Stephen A. Boppart

Stephen A. Boppart is a professor in the Biophotonics Imaging Laboratory at the University of Illinois Urbana Champaign.  Dr. Boppart received his Ph.D. from the Massachusetts Institute of Technology in 1998, followed by a M.D. from Harvard Medical School in 2000. Currently Prof. Boppart is a full-time faculty member in the Beckman Institute Nanoelectronics and Biophotonics Group as well as an associate professor in the UIUC Department of Electrical and Computer Engineering and the Bioengineering Department. In January 2007, he was named the Founding Director of the Mills Breast Cancer Institute at Carle Foundation Hospital. Dr. Boppart is also a Clinical Research Physician in the UI College of Medicine-Urbana. His fields of professional interest include optical imaging (specifically in Optical Coherence Tomography) and biophotonics in medicine and biology.

Quotes

1. “ What is novel about this whole approach and this work is that we’re using external magnetic forces to move nanoparticles within tissue, to modulate them...Most other particles will localize somewhere and typically sit there. They may provide a signal change, but they don’t physically move. No other particle is dynamic like this, which is a unique way to generate contrast. ”

   In New Imaging Method uses Magnetic Nanoparticles that Move

2. “ So now we have a platform where we can target these to a tumor, find them with contrast, measure the mechanical properties, and treat it right there. ”

   In New Imaging Method uses Magnetic Nanoparticles that Move

3. “ And this is found a day later after the surgery has ended....It means that the patient has to come back for another procedure, with all the risks and costs associated with that, and all the anxiety. Another downside for the patient is if there are any tumor cells left behind. These patients are likely to relapse, as there is a fairly high local recurrence rate of tumors that grow back in that area. ”

   In Optics may speed breast cancer diagnosis

4. “ Intraoperative OCT has the potential to provide diagnostically useful information about margin status in real time, at the point of care, rather than relying on postoperative histopathology. ”

   In Optical Coherence Tomography Identifies Surgical Margins for Breast Cancer Intraoperatively

5. “ The imaging depth was equivalent to the tissue depth that pathologists typically examine postoperatively to determine if the margin is negative, close or positive...Image features could also be used to identify structures such as surface blood or cauterised tissue and distinguish these image artifacts from normal and tumour tissue ”

   In Optical Coherence Tomography Identifies Surgical Margins for Breast Cancer Intraoperatively

1. Mentioned In 70 Articles

2. BLI Research Featured by OSA in Whats Hot in Optics

   Explore Article osa.org (Dec 2 2007) Gastroenterology

   ... prep) Intraoperative Optical Biopsy of Breast Cancer FWK1 (10:30 Wed. California): Adam M. Zysk, Stephen A. Boppart Mills Breast Cancer Institute, Carle Foundation Hospital, Biophotonics Imaging Laboratory, Universi......ative tumor margin assessment • identification of lymph node metastasis OCT lymph node histology Boppart, et al. Breast Ca. Res. Treat. 84:85, 2004. Luo, et al. Tech. Ca. Res. Treat., 4:455, 2005. scatt... (Read Full Article)
   

   Comment on Article Mentions:   Matthew J. Crow   Stanford University   Adam Wax

3. Optical coherence tomography: a review of clinical development from bench to bedside

   Explore Article SPIE Digital Library (Oct 24 2007)

   Adam M. Zysk, Freddy T. Nguyen, Amy L. Oldenburg et al. Since its introduction, optical coherence tomography (OCT) technology has advanced from the laboratory bench to the clinic and back again. Arising from the fields of low coherence interferometry and optical time- and frequency-domain reflectometry, OCT was initially demonstrated for retinal imaging ... [J. Biomed. Opt. 12, 051403 (2007)] published Wed Oct 24, 2007. (Read Full Article)
   

   Comment on Article Mentions:   University of Illinois at Urbana-Champaign   Stephen A. Boppart   Amy L. Oldenburg

4. Optical contrast agents for optically modifying incident radiation

   Explore Article uspto.gov (Apr 3 2007) Patents

   ...cal Coherence Tomography. Science 254:1178 1181, 1991.16. Fujimoto J G, Brezinski M E, Tearney G J, Boppart S A, Bouma B E, Hee M R, Southern J F, Swanson E A. Biomedical imaging and optical biopsy using opt... (Read Full Article)
   

   Comment on Article Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign   Daniel L. Marks

5. Interferometric synthetic aperture microscopy

   Explore Article Nature Publishing Group (Jan 21 2007)

   State-of-the-art methods in high-resolution three-dimensional optical microscopy require that the focus be scanned through the entire region of interest. However, an analysis of the physics of the light–sample interaction reveals that the Fourier-space coverage is independent of depth. Here we show that, by solving the inverse scattering problem for interference microscopy, computed reconstruction yields volumes with a resolution in all planes that is equivalent to the resolution achieved only at ... (Read Full Article)
   

   Comment on Article Mentions:   Stephen A. Boppart   University of Illinois at Urbana-Champaign   Tyler S. Ralston

6. Fiber optic needle probes for optical coherence tomography imaging

   Explore Article uspto.gov (May 13 2003) Patents , Probes

   A fiber optic needle probe for measuring or imaging the internal structure of a specimen includes a needle defining a bore, an optical fiber substantially positioned within the bore, and a beam director in optical communication with the optical fiber. At least a portion of the wall of the needle is capable of transmitting light. The beam director directs light from the optical fiber to an internal structure being imaged ... (Read Full Article)
   

   Comment on Article Mentions:   Massachusetts Institute of Technology   James G. Fujimoto   Mark E. Brezinski

7. Fiber optic imaging endoscope interferometer with at least one faraday rotator

   Explore Article uspto.gov (Dec 31 2002) Gastroenterology , Patents , Probes

   An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the ... (Read Full Article)
   

   Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Massachusetts Institute of Technology

8. Methods and apparatus for forward-directed optical scanning instruments

   Explore Article uspto.gov (Nov 26 2002) Gastroenterology , Patents , Probes

   An imaging system for performing forward scanning imaging for application to therapeutic and diagnostic devises used in medical procedures. The imaging system includes forward directed optical coherence tomography (OCT), and non-retroreflected forward scanning OCT. Also interferometric imaging and ranging techniques and fluorescent, Raman, two-photon, and diffuse wave imaging can be used. The forward scanning mechanisms include a cam attached to a motor, pneumatic devices, a pivoting device, piezoelectric transducers, electrostatic ... (Read Full Article)
   

   Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Massachusetts Institute of Technology

9. Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope

   Explore Article uspto.gov (Oct 17 2000) Cardiology , Gastroenterology , Patents , Probes

   An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the ... (Read Full Article)
   

   Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Massachusetts Institute of Technology

10. Surgical diagnostics, guidance, and intervention using optical coherence tomography (Thesis)

    Explore Article DSpace@MIT (Jun 1 1998) Student Theses

    Advances in biomedical imaging technology are rapidly becoming integrated into the surgical suite for image-guidance of interventional procedures. Clinical imaging modalities including computed tomography, magnetic resonance imagine, and ultrasound offer resolutions sufficient to guide placement of surgical instruments, but insufficient to resolve tissue and cellular microstructure. Optical coherence tomography (OCT) is a new high-resolution biomedical imaging modality based on the detection of backscattered near-infrared laser light from tissue. The compact ... (Read Full Article)
    

    Comment on Article Mentions:   Massachusetts Institute of Technology   James G. Fujimoto   Stephen A. Boppart

11. Forward-imaging instruments for optical coherence tomography

    Explore Article opticsinfobase.org (Nov 1 1997) Gastroenterology , Probes

    ...view of the area being imaged. OCT imaging is demonstrated on in vitro human specimens. Citation S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. G. Fujimoto, and M. E. Brezinski, "Forward-imaging instr... (Read Full Article)
    

    Comment on Article Mentions:   Guillermo J. Tearney   Brett E. Bouma   Massachusetts Institute of Technology

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