Physical Sciences Incorporated

1. Mentioned In 17 Articles

2. Stabilized retinal imaging with adaptive optics

   Explore Article uspto.gov (Jul 20 2010) Ophthalmology , Patents

   A system provides an optical image of an object. A first module tracks a reference feature of the object. A second module includes a source for an imaging beam, a scanning device to move the imaging beam along a portion of the object and a detection device receives a signal associated with an image of the portion of the object. The first module controls the position of the imaging beam ... (Read Full Article)
   

   Comment on Article Mentions:   Daniel X. Hammer   Physical Sciences Incorporated   R. Daniel Ferguson

3. High resolution multimodal clinical ophthalmic imaging system

   Explore Article opticsinfobase.org (May 18 2010) Ophthalmology

   We developed a multimodal adaptive optics (AO) retinal imager which is the first to combine high performance AO-corrected scanning laser ophthalmoscopy (SLO) and swept source Fourier domain optical coherence tomography (SSOCT) imaging modes in a single compact clinical prototype platform. Such systems are becoming ever more essential to vision research and are expected to prove their clinical value for diagnosis of retinal diseases, including glaucoma, diabetic retinopathy (DR), age-related macular ... (Read Full Article)
   

   Comment on Article Mentions:   R. Daniel Ferguson   Daniel X. Hammer   Physical Sciences Incorporated

4. Spectral-domain low coherence interferometry/optical coherence tomography system for fine needle breast biopsy guidance

   Explore Article Review of Scientific Instruments (Apr 14 2010)

   A novel technology and instrumentation for fine needle aspiration (FNA) breast biopsy guidance is presented. This technology is based on spectral-domain low coherence interferometry (SD-LCI). The method, apparatus, and preliminary in vitro/in vivo results proving the viability of the method and apparatus are presented in detail. An advanced tissue classification algorithm, preliminarily tested on breast tissue specimens and a mouse model of breast cancer is presented as well. Over 80% ... (Read Full Article)
   

   Comment on Article Mentions:   R. Daniel Ferguson   Daniel X. Hammer   Physical Sciences Incorporated

5. Hybrid spectral domain optical coherence tomography line scanning laser ophthalmoscope

   Explore Article uspto.gov (Jan 19 2010) Ophthalmology , Patents

   An apparatus for imaging an eye includes a housing and a system of optical components disposed in the housing. The apparatus is capable of operating in a line scanning laser ophthalmoscope (LSLO) mode and an optical coherence tomography (OCT) mode. The system of optical components can include a first source to provide a first beam of light for the OCT mode and a second source to provide a second beam ... (Read Full Article)
   

   Comment on Article Mentions:   Daniel X. Hammer   Physical Sciences Incorporated   R. Daniel Ferguson

6. Retinal imaging with polarization-sensitive optical coherence tomography and adaptive optics

   Explore Article opticsinfobase.org (Nov 11 2009) Ophthalmology

   Various layers of the retina are well known to alter the polarization state of light. Such changes in polarization may be a sensitive indicator of tissue structure and function, and as such have gained increased clinical attention. Here we demonstrate a polarization-sensitive optical coherence tomography (PS-OCT) system that incorporates adaptive optics (AO) in the sample arm and a single line scan camera in the detection arm. We quantify the benefit ... (Read Full Article)
   

   Comment on Article Mentions:   Barry Cense   Steven M. Jones   Donald T. Miller

7. Resonant Doppler imaging with common path OCT

   Explore Article SPIE Digital Library (Jul 13 2009) Doppler

   Resonant Doppler flow imaging based on optical coherence tomography (OCT) is a recently developed imaging modality that provides, besides the structural information, dynamic blood flow information. We show that this method can be applied to a common path OCT system by mounting the mirror in the reference arm on a small piezo actor leading to a simpler and more stable system design. Besides the known 3 state cycle, we describe ... (Read Full Article)
   

   Comment on Article Mentions:   Edmund Koch   Daniel X. Hammer   Physical Sciences Incorporated

8. Automated algorithm for breast tissue differentiation in optical coherence tomography

   Explore Article SPIE Digital Library (Jun 26 2009) Oncology

   An automated algorithm for differentiating breast tissue types based on optical coherence tomography (OCT) data is presented. Eight parameters are derived from the OCT reflectivity profiles and their means and covariance matrices are calculated for each tissue type from a training set (48 samples) selected based on histological examination. A quadratic discrimination score is then used to assess the samples from a validation set. The algorithm results for a set ... (Read Full Article)
   

   Comment on Article Mentions:   Daniel X. Hammer   R. Daniel Ferguson   Physical Sciences Incorporated

9. Spectral-domain low coherence interferometry/optical coherence tomography system for fine needle breast biopsy guidance

   Explore Article Scitation (Feb 26 2009) Oncology , Probes

   A novel technology and instrumentation for fine needle aspiration (FNA) breast biopsy guidance is presented. This technology is based on spectral-domain low coherence interferometry (SD-LCI). The method, apparatus, and preliminary in vitro/in vivo results proving the viability of the method and apparatus are presented in detail. An advanced tissue classification algorithm, preliminarily tested on breast tissue specimens and a mouse model of breast cancer is presented as well. Over 80% ... (Read Full Article)
   

   Comment on Article Mentions:   Daniel X. Hammer   Physical Sciences Incorporated   R. Daniel Ferguson

10. Swept-source parallel OCT

    Explore Article SPIE Digital Library (Feb 19 2009)

    We present an optical coherence tomography (OCT) system that can create a full 2D cross-sectional image of a sample within one single spectral sweep of a swept source at a frame rate of 160 fps. The unique combination of line field and swept source technologies in a Fourier domain OCT configuration achieves ultrahigh imaging speeds with a greatly simplified wavelength swept source. The system was initially tested on reflective and ... (Read Full Article)
    

    Comment on Article Mentions:   Physical Sciences Incorporated   Daniel X. Hammer   R. Daniel Ferguson

11. Spectral domain optical coherence tomography for quantitative evaluation of drusen and associated structural changes in non-neovascular age-related macular degeneration

    Explore Article BJO Online (Jan 26 2009) Ophthalmology

    Background/aims: To demonstrate how spectral domain optical coherence tomography (SDOCT) can better evaluate drusen and associated anatomical changes in eyes with non-neovascular age-related macular degeneration (AMD) compared with time domain optical coherence tomography (TDOCT). Methods: Images were obtained from three eyes of three patients with AMD using an experimental SDOCT system. Both a titanium–sapphire (Ti:sapphire) laser and a superluminescent diode (SLD) were used as a broadband light source to achieve ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Physical Sciences Incorporated   Massachusetts Eye and Ear Infirmary

12. Real-time processing for Fourier domain optical coherence tomography using a field programmable gate array

    Explore Article Scitation (Nov 3 2008)

    Teoman E. Ustun, Nicusor V. Iftimia, R. Daniel Ferguson, and Daniel X. Hammer Real-time display of processed Fourier domain optical coherence tomography (FDOCT) images is important for applications that require instant feedback of image information, for example, systems developed for rapid screening or image-guided surgery. However, the computational requirements for high-spe ... [Rev. Sci. Instrum. 79, 114301 (2008)] published Mon Nov 3, 2008. (Read Full Article)
    

    Comment on Article Mentions:   Physical Sciences Incorporated   Daniel X. Hammer   R. Daniel Ferguson

13. Dual-beam Fourier domain optical Doppler tomography of zebrafish

    Explore Article opticsinfobase.org (Aug 20 2008) Developmental Biology , Doppler

    We have developed a dual-beam Fourier domain optical Doppler tomography (FD-ODT) system to image zebrafish (Danio rerio) larvae. Two beams incident on the zebrafish with a fixed angular separation allow absolute blood flow velocity measurement to be made regardless of vessel orientation in a ... [Opt. Express 16, 13624-13636 (2008)] (Read Full Article)
    

    Comment on Article Mentions:   Physical Sciences Incorporated   Daniel X. Hammer   R. Daniel Ferguson

14. Physical Sciences Inc. Adaptive Optics Spectral Domain Optical Coherence Tomography

    Explore Article Physical Sciences Inc. (Aug 12 2008) Ophthalmology

    The adaptive optics spectral domain optical coherence tomography (AO-SDOCT) system combines adaptive optics for detection and correction of ocular aberrations with high-speed SDOCT. The combination of AO for increased lateral resolution with high axial resolution low coherence interferometry allows micron-level resolution of retinal structures and layers. (Read Full Article)
    

    Comment on Article Mentions:   Physical Sciences Incorporated   Daniel X. Hammer

15. Spectral Domain Optical Coherence Tomography for Quantitative Evaluation of Drusen and Associated Structural Changes in Non-Neovascular Age Related Macular Degeneration

    Explore Article BJO Online (Aug 11 2008) Ophthalmology

    Background/Aims: To demonstrate how spectral domain optical coherence tomography (SDOCT) can better evaluate drusen and associated anatomic changes in eyes with non-neovascular age related macular degeneration (AMD) compared to time domain optical coherence tomography (TDOCT). Methods: Images were obtained from 3 eyes of 3 patients with AMD using an experimental SDOCT system. Both a Titanium-sapphire (Ti:Sapphire) laser and a superluminescent diode (SLD) was used as a broadband light source to ... (Read Full Article)
    

    Comment on Article Mentions:   Zeiss Stratus OCT   Tufts University   Massachusetts General Hospital

16. Monitoring blood flow in the retina using a line-scanning laser ophthalmoscope

    Explore Article uspto.gov (Jul 29 2008) Ophthalmology , Patents

    FIELD OF THE INVENTION This invention relates generally to systems and methods for examining eyes. More particularly, the invention relates to systems and methods that employ scanned lines of light for examining eyes and monitoring blood flow in the retina.BACKGROUND OF THE INVENTIONThe retina is among the most highly vascularized and metabolically active tissues in the body. Like the central nervous system of which it is a part, it is ... (Read Full Article)
    

    Comment on Article Mentions:   Physical Sciences Incorporated   Daniel X. Hammer   R. Daniel Ferguson

17. Foveal Fine Structure in Retinopathy of Prematurity: An Adaptive Optics Fourier Domain Optical Coherence Tomography Study

    Explore Article iovs.org (Apr 23 2008) Ophthalmology

    purpose. To describe the fine structure of the fovea in subjects with a history of mild retinopathy of prematurity (ROP) using adaptive optics–Fourier domain optical coherence tomography (AO-FDOCT). methods. High-speed, high-resolution AO-FDOCT videos were recorded in subjects with a history of ROP (n = 5; age range, 14–26 years) and in control subjects (n = 5; age range, 18–25 years). Custom software was used to extract foveal pit depth and ... (Read Full Article)
    

    Comment on Article Mentions:   Daniel X. Hammer   Physical Sciences Incorporated   R. Daniel Ferguson

18. Three dimensional tracking for volumetric spectral-domain optical coherence tomography

    Explore Article opticsinfobase.org (Dec 4 2007) Ophthalmology

    Gopi Maguluri, Mircea Mujat, B. H. Park, K. H. Kim, Wei Sun, N. V. Iftimia, R. D. Ferguson, Daniel X. Hammer, Teresa C. Chen, Johannes F. de BoerWe present a three-dimensional (3D) tracker for a clinical ophthalmic spectral domain optical coherence tomography (SD-OCT) system that combines depth-tracking with lateral tracking, providing a stabilized reference frame for 3D data recording and post acquisition analysis. The depth-tracking ... [Opt. Express 15, 16808-16817 ... (Read Full Article)
    

    Comment on Article Mentions:   Johannes F. de Boer   B. Hyle Park   Daniel X. Hammer

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