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David D. Sampson

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About David D. Sampson

David D. Sampson

David Sampson is the Head of the Optical and Biomedical Engineering Laboratory at the School of Electrical, Electronic and Computer Engineering, Associate Dean of Research, Faculty of Engineering Computing & Mathematics at The University of Western Australia. Professor Sampson has over fifteen years research experience in the fields of optics and photonics, and applications in communications, sensors, and biomedicine.

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His early research in optical communications centred on the technique of photonic code-division multiple access (CDMA). He continues to be well cited for his contributions, which include the invention of several schemes based on broadband light, practical demonstrations, and the understanding of fundamental limits of the optical version of this widely used communications technique. He has also made contributions to wavelength-division multiplexing transmission and networking, through his studies of schemes based on spectrally slicing broadband light. His early demonstration of the modification of the gain spectrum of an optical amplifier through cascaded sections of differently doped fibres predated an explosion of work on gain flattening in optical amplifiers.

At UWA, Prof. Sampson's interests switched to the field of biomedical optical engineering, with an emphasis on imaging and microscopy. His group, the Optical+Biomedical Engineering Laboratory, is involved in activities ranging from the invention and investigation of new optical techniques to the engineering of these techniques into practical instruments for application in biology or medicine. A major emphasis of his research is the coherent imaging modality optical coherence tomography, which continues the theme, begun in his communications research, of exploitation of the coherence properties of broadband light sources. His interest in coherent imaging has recently been extended to Fourier holography. He is also interested in tissue optics and diffuse light propagation in tissue.

Outcomes in optical coherence tomography (OCT) span theory, technology and applications. Theoretical contributions include the determination of limits on resolution set by absorption and dispersion in tissue, and an understanding of OCT speckle. Technology outcomes have centered on frequency-domain optical delay line technology, including demonstrations of ultra-long scanning, variable and dynamic dispersion compensation, and achromatic phase shifting. His most significant practical outcome has been in the development of anatomical OCT, which has enabled the first quantitative long-term bedside observations of the human upper airway during sleep, and which is being used to study sleep apnoea. He remains vitally interested in skin cancer diagnosis through low cost means, and has demonstrated a method based on diffuse reflectance spectroscopy to differentiate between malignant melanoma and benign naevi (moles) in vivo. His most recent outcome is the demonstration of a Fourier holographic microscopy technique that can characterise microstructure in biological samples without directly resolving it, making it possible to quantify large sample areas in a single image.

Prof. Sampson has formed strong collaborations with biological and medical researchers and clinicians. He is a strong promoter of the importance of interdisciplinary engagement as the basis for a stimulating and productive intellectual environment. Prof. Sampson has attracted career research funding of $10.18M, including $1.70M from industry, and published in excess of 60 journal articles with an average citation rate of 8.9 per paper and in excess of 500 ISI citations. He has been invited to speak at 17 conferences in the last five years. He has previously been an associate editor for the Optical Society of America's Applied Optics (1999-2005) and has been involved in the running of more than 20 conferences, including representing the Asia Pacific for the Optical Fiber Communications conference (1996-1998), serving as Technical Programme Chair for the Asia Pacific Communications conference (1997), co-chairing Focus on Microscopy (2006), and chairing the International Conference on Optical Fiber Sensors in 2008.


  1. Mentioned In 32 Articles

  2. Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography

    Explore Article Respiratory Research (Jan 23 2010) Bronchoscopy

    Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography Background Previous histological and imaging studies have shown the presence of variability in the degree of bronchoconstriction of airways sampled at different locations in the lung (i.e., heterogeneity). Heterogeneity can occur at different airway generations and at branching points in the bronchial tree. Whilst heterogeneity has been detected by previous experimental approaches its spatial relationship either within or between airways is unknown. Methods In this study, distribution of airway narrowing ... (Read Full Article)

    Comment on Article Mentions:   Julian J. Armstrong   David D. Sampson   University of Western Australia

  3. Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function

    Explore Article Journal of Applied Physiology (Nov 13 2009) Bronchoscopy

    Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function Regulation of airway caliber by lung volume or bronchoconstrictor stimulation is dependent on physiological, structural and mechanical events within the airway wall, including airway smooth muscle (ASM) contraction, deformation of the mucosa and cartilage, and tensioning of elastic matrices linking wall components. Despite close association between events in the airway wall and the resulting airway caliber these have typically been studied separately: the former primarily using histological approaches, the latter ... (Read Full Article)

    Comment on Article Mentions:   Julian J. Armstrong   David D. Sampson   University of Western Australia

  4. In vivo dynamic optical coherence elastography using a ring actuator

    Explore Article opticsinfobase.org (Nov 12 2009)

    In vivo dynamic optical coherence elastography using a ring actuator ...a ring actuator Brendan F. Kennedy*, Timothy R. Hillman, Robert A. McLaughlin, Bryden C. Quirk, and David D. Sampson Optics Express, Vol. 17, Issue 24, pp. 21762-21772 » View Full Text: Acrobat PDF (324 KB) Open Acce... (Read Full Article)

    Comment on Article Mentions:   Timothy R. Hillman   Robert A. McLaughlin   David D. Sampson

  5. Mapping Tissue Optical Attenuation to Identify Cancer Using Optical Coherence Tomography

    Explore Article SpringerLink Home (Sep 30 2009) Oncology

    ...n L. Jacques, Oregon Health & Science University Biomedical Engineering/Dermatology OR USADavid D. Sampson, Uni. Western Australia Optical+Biomedical Engineering Laboratory WA Australia Book Seri... (Read Full Article)

    Comment on Article Mentions:   David D. Sampson   Sir Charles Gairdner Hospital   Robert A. McLaughlin

  6. Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques

    Explore Article European Respiratory Journal (Jul 1 2009) Bronchoscopy , Otolaryngology

    ...imitations and emerging techniques J. P. Williamson^1^,2, A. L. James^1^,3^,4, M. J. Phillips^5, D. D. Sampson^6, D. R. Hillman^1^,3 and P. R. Eastwood^1^,2^,3 Depts of ^1 Pulmonary Physiology, and ^5 Respirato... (Read Full Article)

    Comment on Article Mentions:   David D. Sampson   University of Western Australia   Sir Charles Gairdner Hospital

  7. Measuring airway dimensions during bronchoscopy using anatomical optical coherence tomography

    Explore Article European Respiratory Journal (Jun 21 2009) Otolaryngology

    ...ger ^2, J.J. Armstrong ^3, H.W. Mitchell ^4, R.A. McLaughlin ^3, M.J. Phillips ^5, P.B. Noble ^6, D.D. Sampson ^3, A.R. West ^4, D.R. Hillman ^7, S. Becker ^3, P.R. Eastwood ^8, A. Curatolo ^3 ^1 Dept of Pulmon... (Read Full Article)

    Comment on Article Mentions:   Julian J. Armstrong   David D. Sampson   University of Western Australia

  8. A Method Of Providing Quantitative Information About The Lower Airways Of A Lung (Wo 2009/059368)

    Explore Article wipo.int (May 14 2009) Bronchoscopy , Patents

    A Method Of Providing Quantitative Information About The Lower Airways Of A Lung (Wo 2009/059368) The present disclosure provides a method of providing quantitative information about a property of the lower airways of a lung using optical coherence tomography. The method comprises inserting a probe head of an anatomical optical coherence tomography device into the lower airways. Further, the method comprises directing light to, and receiving reflected light from, an internal wall portion of the lower airways. The light is suitable for optical coherence tomography. ... (Read Full Article)

    Comment on Article Mentions:   University of Western Australia   Julian J. Armstrong   David D. Sampson

  9. Audio frequency in vivo optical coherence elastography

    Explore Article Institute of Physics (May 5 2009)

    Abstract. We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of ... (Read Full Article)

    Comment on Article Mentions:   University of Illinois at Urbana-Champaign   University of Western Australia   Julian J. Armstrong

  10. Technology Testing Update Including Recent in vivo University Study Results

    Explore Article smh.com.au (Apr 6 2009) Dermatology

    ...ment is operated by experts in optical imaging and characterisation of skin and headed by Professor David Sampson. OCT produces 3-dimensional images of the skin's microstructures to a depth of 2 to 3 mm. It co... (Read Full Article)

    Comment on Article Mentions:   University of Western Australia   David D. Sampson   University of Queensland

  11. Respiratory gating of anatomical optical coherence tomography images of the human airway

    Explore Article opticsinfobase.org (Apr 6 2009) Bronchoscopy

    Respiratory gating of anatomical optical coherence tomography images of the human airway ... J. Armstrong, Sven Becker, Jennifer H. Walsh, Arpit Jain, David R. Hillman, Peter R. Eastwood, and David D. Sampson Optics Express, Vol. 17, Issue 8, pp. 6568-6577 doi:10.1364/OE.17.006568 » V... (Read Full Article)

    Comment on Article Mentions:   David R. Hillman   University of Maryland   Julian J. Armstrong

  12. Regional Airway Compliance in Asthma Measured Using Anatomical Optical Coherence Tomography

    Explore Article ajrccm.atsjournals.org (Mar 25 2009) Bronchoscopy

    No Abstract Provided (Read Full Article)

    Comment on Article Mentions:   Julian J. Armstrong   David D. Sampson   University of Western Australia

  13. Lymph node micro-architecture can be imaged using optical coherence tomography

    Explore Article Cancer Research (Mar 4 2009) Oncology

    Lymph node micro-architecture can be imaged using optical coherence tomography Background: Histological assessment is the gold standard technique for identification of lymph node involvement in breast cancer. However, this may only be performed ex vivo and will often result in the unnecessary excision of healthy lymph nodes. In axillary clearance, this will result in lymphedema in approximately 26% of patients. Optical Coherence Tomography (OCT) is a real-time imaging modality with the potential to perform in vivo optical biopsy of lymph ... (Read Full Article)

    Comment on Article Mentions:   David D. Sampson   University of Western Australia   Robert A. McLaughlin

  14. Using Optical Coherence Tomography To Improve Diagnostic and Therapeutic Bronchoscopy

    Explore Article CHEST (Feb 20 2009) Bronchoscopy

    ... J. Phillips, MBBS, 4. Julian J. Armstrong, PhD, 5. Sven Becker, MSc, 6. Jennifer H. Walsh, PhD, 7. David D. Sampson, PhD, 8. David R. Hillman, MBBS and 9. Peter R. Eastwood, PhD 1. From the Department of Pulmonary P... (Read Full Article)

    Comment on Article Mentions:   Julian J. Armstrong   Robert A. McLaughlin   Martin J. Phillips

  15. New camera sees snoring in action

    Explore Article ScienceAlert (Dec 2 2008) Otolaryngology

    ... upper airway collapsing and reopening. This is a truly unique study, according to OBEL’s Professor David Sampson. “Overnight sleep studies cannot be done any other way. MRI could be used if a subject could get co... (Read Full Article)

    Comment on Article Mentions:   David D. Sampson   University of Western Australia

  16. OSA's Interactive Science Publishing Initiative Launches with Research on Breathing Disorders and Congenital Heart Defects

    Explore Article Newswise (Oct 31 2008)

    ...n, J. P. Williamson, M. J. Phillips, J. J. Armstrong, S. Becker, D. R. Hillman, P. R. Eastwood, and D. D. Sampson, "Applying anatomical optical coherence tomography to quantitative 3D imaging of the lower air... (Read Full Article)

    Comment on Article Mentions:   Duke University   University of Western Australia   Florence G. Rothenberg

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