David D. Sampson

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About David D. Sampson

David D. Sampson

David Sampson is the Head of the Optical and Biomedical Engineering Laboratory at the School of Electrical, Electronic and Computer Engineering, Associate Dean of Research, Faculty of Engineering Computing & Mathematics at The University of Western Australia. Professor Sampson has over fifteen years research experience in the fields of optics and photonics, and applications in communications, sensors, and biomedicine.

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His early research in optical communications centred on the technique of photonic code-division multiple access (CDMA). He continues to be well cited for his contributions, which include the invention of several schemes based on broadband light, practical demonstrations, and the understanding of fundamental limits of the optical version of this widely used communications technique. He has also made contributions to wavelength-division multiplexing transmission and networking, through his studies of schemes based on spectrally slicing broadband light. His early demonstration of the modification of the gain spectrum of an optical amplifier through cascaded sections of differently doped fibres predated an explosion of work on gain flattening in optical amplifiers.

At UWA, Prof. Sampson's interests switched to the field of biomedical optical engineering, with an emphasis on imaging and microscopy. His group, the Optical+Biomedical Engineering Laboratory, is involved in activities ranging from the invention and investigation of new optical techniques to the engineering of these techniques into practical instruments for application in biology or medicine. A major emphasis of his research is the coherent imaging modality optical coherence tomography, which continues the theme, begun in his communications research, of exploitation of the coherence properties of broadband light sources. His interest in coherent imaging has recently been extended to Fourier holography. He is also interested in tissue optics and diffuse light propagation in tissue.

Outcomes in optical coherence tomography (OCT) span theory, technology and applications. Theoretical contributions include the determination of limits on resolution set by absorption and dispersion in tissue, and an understanding of OCT speckle. Technology outcomes have centered on frequency-domain optical delay line technology, including demonstrations of ultra-long scanning, variable and dynamic dispersion compensation, and achromatic phase shifting. His most significant practical outcome has been in the development of anatomical OCT, which has enabled the first quantitative long-term bedside observations of the human upper airway during sleep, and which is being used to study sleep apnoea. He remains vitally interested in skin cancer diagnosis through low cost means, and has demonstrated a method based on diffuse reflectance spectroscopy to differentiate between malignant melanoma and benign naevi (moles) in vivo. His most recent outcome is the demonstration of a Fourier holographic microscopy technique that can characterise microstructure in biological samples without directly resolving it, making it possible to quantify large sample areas in a single image.

Prof. Sampson has formed strong collaborations with biological and medical researchers and clinicians. He is a strong promoter of the importance of interdisciplinary engagement as the basis for a stimulating and productive intellectual environment. Prof. Sampson has attracted career research funding of $10.18M, including $1.70M from industry, and published in excess of 60 journal articles with an average citation rate of 8.9 per paper and in excess of 500 ISI citations. He has been invited to speak at 17 conferences in the last five years. He has previously been an associate editor for the Optical Society of America's Applied Optics (1999-2005) and has been involved in the running of more than 20 conferences, including representing the Asia Pacific for the Optical Fiber Communications conference (1996-1998), serving as Technical Programme Chair for the Asia Pacific Communications conference (1997), co-chairing Focus on Microscopy (2006), and chairing the International Conference on Optical Fiber Sensors in 2008.


  1. Mentioned In 38 Articles

  2. Method and apparatus for measurement of optical properties in tissue

    Explore Article uspto.gov (Aug 31 2010) Patents , Probes

    Method and apparatus for measurement of optical properties in tissue A method of analyzing tissue includes inserting a radiation source into tissue, impinging radiation upon the tissue, obtaining a sample signal of the radiation that impinges upon the tissue, and determining a refractive index of the tissue from the sample signal. The method may also include determining at least one other optical property of the tissue. The method may provide for identifying tissue as part of a biopsy method. A ... (Read Full Article)

    Comment on Article Mentions:   Stephen A. Boppart   Julian J. Armstrong   David D. Sampson

  3. Parametric imaging of cancer with optical coherence tomography

    Explore Article SPIE Digital Library (Aug 19 2010) Oncology

    Parametric imaging of cancer with optical coherence tomography ...of Biomedical Engineering and Department of Dermatology, 3303 SW Bond Avenue, Portland Oregon 97239 David D. Sampson University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optica... (Read Full Article)

    Comment on Article Mentions:   University of Western Australia   Steven L. Jacques   Loretta Scolaro

  4. Speckle reduction in optical coherence tomography by strain compounding

    Explore Article opticsinfobase.org (Jul 13 2010)

    Speckle reduction in optical coherence tomography by strain compounding ...rence tomography by strain compounding Brendan F. Kennedy, Timothy R. Hillman, Andrea Curatolo, and David D. Sampson Optics Letters, Vol. 35, Issue 14, pp. 2445-2447 (2010) doi:10.1364/OL.35.002445 » V... (Read Full Article)

    Comment on Article Mentions:   Brendan F. Kennedy   Timothy R. Hillman   Massachusetts Institute of Technology

  5. Detection of multiple scattering in optical coherence tomography by speckle correlation of angle-dependent B-scans

    Explore Article opticsinfobase.org (Jun 8 2010)

    Detection of multiple scattering in optical coherence tomography by speckle correlation of angle-dependent B-scans ...correlation of angle-dependent B-scans Timothy R. Hillman, Andrea Curatolo, Brendan F. Kennedy, and David D. Sampson Optics Letters, Vol. 35, Issue 12, pp. 1998-2000 (2010) doi:10.1364/OL.35.001998 » V... (Read Full Article)

    Comment on Article Mentions:   Timothy R. Hillman   David D. Sampson   University of Western Australia

  6. Fibrin phantom for use in optical coherence tomography

    Explore Article SPIE Digital Library (May 10 2010)

    Fibrin phantom for use in optical coherence tomography ...endan F. Kennedy,^1 Susanne Loitsch,^1 Robert A. McLaughlin,^1 Loretta Scolaro,^1 Paul Rigby,^2 and David D. Sampson^1,2 ^1The University of Western Australia, Optical+Biomedical Engineering Laboratory, School of El... (Read Full Article)

    Comment on Article Mentions:   University of Western Australia   Loretta Scolaro   Robert A. McLaughlin

  7. Imaging of Human Lymph Nodes Using Optical Coherence Tomography: Potential for Staging Cancer

    Explore Article Cancer Research (Mar 17 2010) Oncology

    Imaging of Human Lymph Nodes Using Optical Coherence Tomography: Potential for Staging Cancer Histologic assessment is the gold standard technique for the identification of metastatic involvement of lymph nodes in malignant disease, but can only be performed ex vivo and often results in the unnecessary excision of healthy lymph nodes, leading to complications such as lymphedema. Optical coherence tomography (OCT) is a high-resolution, near-IR imaging modality capable of visualizing microscopic features within tissue. OCT has the potential to provide in vivo assessment of ... (Read Full Article)

    Comment on Article Mentions:   David D. Sampson   University of Western Australia   Robert A. McLaughlin

  8. Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography

    Explore Article Respiratory Research (Jan 23 2010) Pulmonology

    Distribution of airway narrowing responses across generations and at branching points, assessed in vitro by anatomical optical coherence tomography Background Previous histological and imaging studies have shown the presence of variability in the degree of bronchoconstriction of airways sampled at different locations in the lung (i.e., heterogeneity). Heterogeneity can occur at different airway generations and at branching points in the bronchial tree. Whilst heterogeneity has been detected by previous experimental approaches its spatial relationship either within or between airways is unknown. Methods In this study, distribution of airway narrowing ... (Read Full Article)

    Comment on Article Mentions:   Julian J. Armstrong   David D. Sampson   University of Western Australia

  9. Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function

    Explore Article Journal of Applied Physiology (Nov 13 2009) Pulmonology

    Airway Narrowing Assessed by Anatomical Optical Coherence Tomography In Vitro: Dynamic Airway Wall Morphology and Function Regulation of airway caliber by lung volume or bronchoconstrictor stimulation is dependent on physiological, structural and mechanical events within the airway wall, including airway smooth muscle (ASM) contraction, deformation of the mucosa and cartilage, and tensioning of elastic matrices linking wall components. Despite close association between events in the airway wall and the resulting airway caliber these have typically been studied separately: the former primarily using histological approaches, the latter ... (Read Full Article)

    Comment on Article Mentions:   Julian J. Armstrong   David D. Sampson   University of Western Australia

  10. In vivo dynamic optical coherence elastography using a ring actuator

    Explore Article opticsinfobase.org (Nov 12 2009)

    In vivo dynamic optical coherence elastography using a ring actuator ...a ring actuator Brendan F. Kennedy*, Timothy R. Hillman, Robert A. McLaughlin, Bryden C. Quirk, and David D. Sampson Optics Express, Vol. 17, Issue 24, pp. 21762-21772 » View Full Text: Acrobat PDF (324 KB) Open Acce... (Read Full Article)

    Comment on Article Mentions:   Timothy R. Hillman   Robert A. McLaughlin   David D. Sampson

  11. Mapping Tissue Optical Attenuation to Identify Cancer Using Optical Coherence Tomography

    Explore Article SpringerLink Home (Sep 30 2009) Oncology

    ...teven L. Jacques, Oregon Health & Science University Biomedical Engineering/Dermatology OR USADavid D. Sampson, Uni. Western Australia Optical+Biomedical Engineering Laboratory WA Australia Book Seri... (Read Full Article)

    Comment on Article Mentions:   David D. Sampson   Sir Charles Gairdner Hospital   Robert A. McLaughlin

  12. Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques

    Explore Article European Respiratory Journal (Jul 1 2009) Otolaryngology , Pulmonology

    ...imitations and emerging techniques J. P. Williamson^1^,2, A. L. James^1^,3^,4, M. J. Phillips^5, D. D. Sampson^6, D. R. Hillman^1^,3 and P. R. Eastwood^1^,2^,3 Depts of ^1 Pulmonary Physiology, and ^5 Respirato... (Read Full Article)

    Comment on Article Mentions:   David D. Sampson   University of Western Australia   Sir Charles Gairdner Hospital

  13. Measuring airway dimensions during bronchoscopy using anatomical optical coherence tomography

    Explore Article European Respiratory Journal (Jun 21 2009) Otolaryngology

    ...ger ^2, J.J. Armstrong ^3, H.W. Mitchell ^4, R.A. McLaughlin ^3, M.J. Phillips ^5, P.B. Noble ^6, D.D. Sampson ^3, A.R. West ^4, D.R. Hillman ^7, S. Becker ^3, P.R. Eastwood ^8, A. Curatolo ^3 ^1 Dept of Pulmon... (Read Full Article)

    Comment on Article Mentions:   Julian J. Armstrong   David D. Sampson   University of Western Australia

  14. A Method Of Providing Quantitative Information About The Lower Airways Of A Lung (Wo 2009/059368)

    Explore Article wipo.int (May 14 2009) Pulmonology , Patents

    A Method Of Providing Quantitative Information About The Lower Airways Of A Lung (Wo 2009/059368) The present disclosure provides a method of providing quantitative information about a property of the lower airways of a lung using optical coherence tomography. The method comprises inserting a probe head of an anatomical optical coherence tomography device into the lower airways. Further, the method comprises directing light to, and receiving reflected light from, an internal wall portion of the lower airways. The light is suitable for optical coherence tomography. ... (Read Full Article)

    Comment on Article Mentions:   University of Western Australia   Julian J. Armstrong   David D. Sampson

  15. Audio frequency in vivo optical coherence elastography

    Explore Article Institute of Physics (May 5 2009)

    Abstract. We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of ... (Read Full Article)

    Comment on Article Mentions:   University of Illinois at Urbana-Champaign   University of Western Australia   Julian J. Armstrong

  16. Technology Testing Update Including Recent in vivo University Study Results

    Explore Article smh.com.au (Apr 6 2009) Dermatology

    ...ment is operated by experts in optical imaging and characterisation of skin and headed by Professor David Sampson. OCT produces 3-dimensional images of the skin's microstructures to a depth of 2 to 3 mm. It constr... (Read Full Article)

    Comment on Article Mentions:   University of Western Australia   David D. Sampson   University of Queensland

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