Bioptigen

About Bioptigen

Bioptigen.  Ophthalmology and General Research Systems.  Bioptigen has pioneered a new class of in vivo optical imaging systems for biomedical applications. These systems enable real-time non-invasive imaging of internal tissue microstructure, advancing critical applications in drug development, genetics research, tissue engineering, and medical vision.  Bioptigen is a spin-out of the Duke University Biomedical Engineering Department. Bioptigen was incorporated in North Carolina in August, 2004, to commercialize technologies originating in the laboratories of Professor Joseph Izatt. Bioptigen technology is based on the science of Optical Coherence Tomography (OCT), an imaging system similar in function to ultrasound, but using low-power light rather than sound waves. OCT offers resolution 100-times finer than standard ultrasound, suitable for analyzing tissue microstructure with features smaller than 10 micrometer.

Quotes about Bioptigen

1. “ Bioptigen allows you to sum up multiple images of a particular cut. ”

   In New Technology: Bioptigen SDOCT Boosts Flexibility

2. “ Bioptigen is very pleased to extend its relationship with Case through this new technology agreement.  The intellectual property licensed by Case is fundamental to our ability to provide the highest performance FDOCT imaging system today and to develop new clinical tools that will dramatically extend the clinical value of FDOCT into the future. ”

   Eric L. Buckland in Case Western Reserve University, University Hospitals Case Medical Center and Bioptigen Establish Exclusive Licensing Agreement

3. “ We look forward to working with Bioptigen to incorporate the Case technology and expand their product portfolio to address medical disciplines beyond ocular imaging. ”

   In Case Western Reserve University, University Hospitals Case Medical Center and Bioptigen Establish Exclusive Licensing Agreement

1. Mentioned In 57 Articles

2. Reproducibility of Spectral-Domain Optical Coherence Tomography Total Retinal Thickness Measurements in Mice

   Explore Article iovs.org (Jun 27 2010) Ophthalmology

   ... acquired in both eyes with SD-OCT (250x250x1024 samplings, centered on the optic nerve head (ONH); Bioptigen, Inc, Durham, NC). Mice were repositioned in between each scan. TRT was automatically measured with... (Read Full Article)
   

   Comment on Article Mentions:   University of Pittsburgh   Joel S. Schuman   Larry Kagemann

3. Methods, systems and computer program products for removing undesired artifacts in fourier domain optical coherence tomography (fdoct) systems using continuous phase modulation and related phase modulators

   Explore Article uspto.gov (Jun 22 2010) Patents

   Methods, fourier domain optical coherence tomography (FDOCT) interferometers and computer program products are provided for removing undesired artifacts in FDOCT systems using continuous phase modulation. A variable phase delay is introduced between a reference arm and a sample arm of an FDOCT interferometer using continuous phase modulation. Two or more spectral interferograms having different phase delay integration times are generated. The spectral interferograms are combined using signal processing to remove ... (Read Full Article)
   

   Comment on Article Mentions:   Joseph A. Izatt   Eric L. Buckland   Bioptigen

4. Methods, Systems And Computer Program Products For Biometric Identification By Tissue Imaging Using Optical Coherence Tomography (Oct) (Wo 2010/062883)

   Explore Article wipo.int (Jun 3 2010) Patents

   Optical coherence tomography (OCT) imaging systems for imaging uniquely identifiable structure are provided including a source having an associated source arm path and having an associated reference arm path coupled to the source path, the reference arm path having an associated reference arm path length. A sample having an associated sample arm path coupled to the source arm and reference arm paths is provided. Processing methods to convert the depth-dependent ... (Read Full Article)
   

   Comment on Article Mentions:   Eric L. Buckland   Bioptigen   Bradley A. Bower

5. Methods, systems and computer program products for optical coherence tomography (oct) using automatic dispersion compensation

   Explore Article uspto.gov (May 18 2010) Patents

   Methods, systems and computer program products for generating parameters for software dispersion compensation in optical coherence tomography (OCT) systems are provided. Raw spectral interferogram data is acquired for a given lateral position on a sample and a given reference reflection. A trial spectral phase corresponding to each wavenumber sample of the acquired spectral interferogram data is postulated. The acquired raw spectral data and the postulated trial spectral phase data are ... (Read Full Article)
   

   Comment on Article Mentions:   Joseph A. Izatt   Eric L. Buckland   Bioptigen

6. Bioptigen and OCT News Travel Stipend To Help Provide Eye Care Services In Haiti

   Explore Article Optical Coherence Tomography News (May 14 2010) Ophthalmology

   ...ver general medical aid, optometric care, ophthalmic services, and ocular surgery where necessary. Bioptigen is supporting this effort to extend relief services to the field of general eye care and ocular tra... (Read Full Article)
   

   Comment on Article Mentions:   Eric L. Buckland   Bioptigen   Eric A. Swanson

7. Hand Held Imaging Device Provides Important Evidence in Diagnosis of Shaken Baby Syndrome

   Explore Article PR Newswire (Apr 16 2010) Ophthalmology

   Ophthalmologists examining infants for possible Shaken Baby Syndrome (SBS) found that a handheld Spectral Domain Optical Coherence Tomography (SD-OCT) device provided high-resolution images of the retina and the vitreoretinal interface in infants with SBS, reports a study in the current issue of Retina, The Journal of Retinal and Vitreous Diseases. According to Thomas Lee, MD, Director of the Retina Institute in The Vision Center at Childrens Hospital Los Angeles, and ... (Read Full Article)
   

   Comment on Article Mentions:   Thomas C. Lee   Bioptigen

8. Identification and Assessment of Schlemm's Canal by Spectral Domain Optical Coherence Tomography

   Explore Article iovs.org (Mar 19 2010) Ophthalmology

   ...of living humans. Methods: SC was imaged by spectral-domain optical coherence tomography (SD-OCT, Bioptigen Inc, USA) with a 200 nm bandwidth light source (SuperLum LTD., Ireland). Both eyes of 21 healthy su... (Read Full Article)
   

   Comment on Article Mentions:   University of Pittsburgh   Joel S. Schuman   Bioptigen

9. Gene Deletion Screen for Cardiomyopathy in Adult Drosophila Identifies a New Notch Ligand

   Explore Article Circulation Research (Mar 7 2010) Cardiology , Developmental Biology

   Rationale: Drosophila has been recognized as a model to study human cardiac diseases. Objective: Despite these findings, and the wealth of tools that are available to the fly community, forward genetic screens for adult heart phenotypes have been rarely performed because of the difficulty in accurately measuring cardiac function in adult Drosophila. Methods and Results: Using optical coherence tomography to obtain real-time analysis of cardiac function in awake Drosophila, we ... (Read Full Article)
   

   Comment on Article Mentions:   Duke University   Bioptigen

10. Revealing the Body's Deepest Secrets

    Explore Article parade.com (Feb 19 2010)

    For more than a century, X-rays have allowed doctors to observe the inner workings of the human body. Today a new generation of imaging devices is probing even deeper—and transforming medicine in the process. Take the case of a 53-year-old woman rushed to the emergency room of Suburban Hospital in Bethesda, Md., with chest pains. Heart attack or just indigestion? It’s a common dilemma. Every minute counts when treating heart ... (Read Full Article)
    

    Comment on Article Mentions:   Rice University   National Institutes of Health   Yale University

11. Unusual Adaptive Optics Findings in a Patient With Bilateral Maculopathy

    Explore Article Archives of Ophthalmology (Feb 8 2010) Ophthalmology

    Over the past decade there has been a rapid evolution in our ability to noninvasively image the living human retina. Of particular interest is adaptive optics (AO), a technique that corrects for the eye's monochromatic aberrations and allows nearly diffraction-limited imaging of the retina.1 There is increasing clinical application of AO imaging2-5 owing to the ability to resolve retinal pathological changes on a cellular level, although the future of AO ... (Read Full Article)
    

    Comment on Article Mentions:   University of Wisconsin   Heidelberg Engineering   Bioptigen

12. Spectral-Domain Optical Coherence Tomography and Adaptive Optics May Detect Hydroxychloroquine Retinal Toxicity Before Symptomatic Vision Loss

    Explore Article aosonline.org (Feb 4 2010) Ophthalmology

    ...al architecture was preserved in both patients. FIGURE 1 Patient 1. Fluorescein angiogram (FA) and Bioptigen SD-OCT images of left eye. SD-OCT images are registered onto FA fundus photo. Upper SD-OCT image is... (Read Full Article)
    

    Comment on Article Mentions:   University of Wisconsin   Bioptigen

13. Big Ideas from Small Businesses: Vision-related research by innovative thinkers - Imaging the eyes of infants

    Explore Article nei.nih.gov (Feb 2 2010) Ophthalmology , Other Business News

    ..."The research community was asking for these tools," he explains. Buckland and Izatt co-founded Bioptigen, Inc. in 2004. They used NEI SBIR funding to develop a versatile OCT system that includes interchan... (Read Full Article)
    

    Comment on Article Mentions:   Eric L. Buckland   Bioptigen   Joseph A. Izatt

14. Optical Coherence Tomography (OCT) Imaging Systems For Use In Pediatric Ophthalmic Applications And Related Methods And Computer Program Products (Wo 2009/131679)

    Explore Article wipo.int (Oct 29 2009) Ophthalmology , Patents

    Optical coherence tomography (OCT) imaging systems for imaging an eye are provided including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path, the reference arm path having an associated reference arm path length. A sample having an associated sample arm path coupled to the source arm and reference arm paths is provided. A reference arm path ... (Read Full Article)
    

    Comment on Article Mentions:   Joseph A. Izatt   Eric L. Buckland   Bioptigen

15. Optical Coherence Tomography (OCT) Imaging Systems Having Adaptable Lens Systems And Related Methods And Computer Program Products (Wo 2009/131701)

    Explore Article wipo.int (Oct 29 2009) Ophthalmology , Patents

    OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal ... (Read Full Article)
    

    Comment on Article Mentions:   Joseph A. Izatt   Eric L. Buckland   Bioptigen

16. Case Western Reserve University, University Hospitals Case Medical Center and Bioptigen Establish Exclusive Licensing Agreement

    Explore Article Optical Coherence Tomography News (Oct 24 2009) Other Business News , Patents

    Case Western Reserve University, University Hospitals Case Medical Center and Bioptigen Establish Exclusive Licensing Agreement Technology Helps Doctors and Researchers Diagnose and See... (Read Full Article)
    

    Comment on Article Mentions:   Joseph A. Izatt   Andrew M. Rollins   Duke University

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