1. Articles in category: Gastroenterology

    457-480 of 557 « 1 2 ... 17 18 19 20 21 22 23 24 »
    1. Forward-Looking, Optical Coherence Tomography Endoscope (Wo 2008/045851)

      A forward-looking, optical coherence tomography, endoscopic probe is disclosed capable of high resolution with a small diameter. Light is focused and scanned during three passes through a lens. A light source supplies light to the proximal side of the lens. The light makes a first pass through the lens, and is reflected from a fixed mirror on the distal side. The reflected light makes a second pass from the distal side to the proximal side, and exits the lens at the proximal side, and is reflected by a scanning mirror. The light makes a third pass through the lens from ...
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    2. Anatomical Optical Coherence Tomography for Long-Term, Portable, Quantitative Endoscopy

      n this paper, we report on anatomical optical coherence tomography, a catheter-based optical modality designed to provide quantitative sectional images of internal hollow organ anatomy over extended observational periods. We consider the design and performance of an instrument and its initial intended application in the human upper airway for the characterization of obstructive sleep apnea (OSA). Compared with current modalities, the technique uniquely combines quantitative imaging, bedside operation, and safety for use over extended periods of time with no cumulative dose limit. Our experiments show that the instrument is capable of imaging subjects during sleep, and that it can record ...
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    3. In vivo Optical Coherence Tomography Imaging of Preinvasive Bronchial Lesions

      Purpose: Optical coherence tomography (OCT) is an optical imaging method that can visualize cellular and extracellular structures at and below tissue surface. The objective of the study was to determine if OCT could characterize preneoplastic changes in the bronchial epithelium identified by autofluorescence bronchoscopy. Experimental Design: A 1.5-mm fiberoptic probe was inserted via a bronchoscope into the airways of 138 volunteer heavy smokers participating in a chemoprevention trial and 10 patients with lung cancer to evaluate areas that were found to be normal or abnormal on autofluorescence bronchoscopy. Radial scanning of the airways was done to generate OCT images ...
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    4. Fiber optic tunable probe for endoscopic optical coherence tomography

      Khaled Aljasem, Armin Werber, Andreas Seifert and Hans Zappe Abstract. A novel miniaturized fiber optic tunable endoscopic probe based on a pneumatically actuated micro-lens is presented. The probe has a diameter of ~4 mm and is integrated into a time-domain optical coherence tomography (OCT) system. The integration of the tunable lens with the OCT system leads to a uniformly high lateral resolution and high contrast of the OCT images over the entire scan depth. In addition, the tunable probe can be considered as a platform for integrating multiple microsystems, including particularly scanning micro-mirrors, in a single high-performance endoscopic OCT system.
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    5. Optical Coherence Tomography Imaging as a Quality Assurance Tool for Evaluating Endoscopic Harvest of the Radial Artery

      Background: Concerns about intimal disruption and spasm have limited enthusiasm for endoscopic radial artery harvest (ERAH), although the risk of these problems after this procedure remains uncertain. Radial artery conduits were screened intraoperatively before and after ERAH vs open harvest using catheter-based high-resolution optical coherence tomography (OCT) imaging. Methods: Twenty-four cadavers and 60 coronary artery bypass graft (CABG) patients scheduled to receive a RA graft underwent OCT imaging before (in situ) and after (ex vivo) open harvest or ERAH. Spasm was quantified by the percentage change in luminal volume between images. Intimal disruption was classified as minor or severe depending ...
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    6. Role of optical techniques in combined use of selected methods of medical imaging

      Abstract  The subject matter of this paper concerns advanced techniques of imaging used in diagnosis and minimally invasive procedures applied in non-operable cases of the digestive tract tumour therapy. The role of optical techniques in current medical imaging is significant. Optical properties of transilluminated or illuminated tissues and organs depend on strong light absorption and scattering. Numerous issues related to the result interpretation still remain unsolved. Effectiveness and precision can be especially improved when some combined methods of imaging are used. Videoendoscopy imaging, X-ray imaging, and endoscopic ultrasound imaging are three complementary methods applied during the interventions described in this ...
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    7. Electrostatic forward-viewing scanning probe for Doppler optical coherence tomography using a dissipative polymer catheter

      Nigel R. Munce, Adrian Mariampillai, Beau A. Standish, Mihaela Pop, Kevan J. Anderson, George Y. Liu, Tim Luk, Brian K. Courtney, Graham A. Wright, I. Alex Vitkin, Victor X. D. Yang. A novel flexible scanning optical probe is constructed with a finely etched optical fiber strung through a platinum coil in the lumen of a dissipative polymer. The packaged probe is 2.2mm in diameter with a rigid length of 6mm when using a ball lens or 12mm when scanning the fiber proximal to a ... [Opt. Lett. 33, 657-659 (2008)]
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    8. From chromoendoscopy to confocal microscopy: Recent developments in endoscopic imaging of the colon

      Abstract  Recent advances in optical physics and bioengineering have given rise to a wealth of novel technologies for gastrointestinal endoscopy, which may make possible the real-time detection of neoplasia in the colon. Conventional diagnostic endoscopy is limited to a gross view of gastrointestinal mucosa, but several new, light-based technologies allow a glimpse of the colon at the subcellular level. Currently, “optical biopsies” must still be correlated with pathologic biopsies to ensure accuracy. Soon, however, these modalities, alone or in combination, will provide accurate, real-time subcellular imaging and in vivo histopathologic diagnoses. Content Type Journal ArticleDOI 10.1007/s11888-007-0028-0Authors Caren PaleseSharmila ...
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    9. Endoscopic spectral-domain polarization-sensitive optical coherence tomography system

      Yi Wang, Xiaodong Chen, Zhiqiang Hu et al. In this paper, we introduced a fiber-based endoscopic Spectral-domain Polarization-sensitive OCT (SD-PS-OCT)experimental scheme for detecting the internal organ disease, which is based on low-coherence interferometer and twospectrometers. The SD-PS-OCT has the advantages of both Spectral-domain OCT ... [Proc. SPIE Int. Soc. Opt. Eng. 6621, 66211K (2008)] published Mon Mar 3, 2008.
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    10. Recent advances and novel methods in pancreatic imaging

      Traditional imaging studies for evaluating pancreatic disease including abdominal ultrasound (US) and computerized tomography (CT) are widely utilized due to their availability, non-invasiveness, and familiarity to practitioners. The addition of endoscopic ultrasound (EUS) and magnetic resonance imaging (MRI) and magnetic resonance cholangiopancreatography (MRCP) has contributed significantly to the clinician's the ability to safely sample tissue, stage malignancy, evaluate the pancreatic ductal anatomy, and look for subtle parenchymal changes in the setting of chronic pancreatitis. The role of endoscopic retrograde cholangiopancreatography (ERCP) has diminished with the use of these less invasive modalities. Limitations in these conventional techniques include a lack ...
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    11. Three-dimensional endomicroscopy using optical coherence tomography

      Optical coherence tomography enables micrometre-scale, subsurface imaging of biological tissue by measuring the magnitude and echo time delay of backscattered light. Endoscopic optical coherence tomography imaging inside the body can be performed using fibre-optic probes. To perform three-dimensional optical coherence tomography endomicroscopy with ultrahigh volumetric resolution, however, requires extremely high imaging speeds. Here we report advances in optical coherence tomography technology using a Fourier-domain mode-locked frequency-swept laser as the light source. The laser, with a 160-nm tuning range at a wavelength of 1,315 nm, can produce images with axial resolutions of 5–7 m. In vivo three-dimensional optical coherence ...
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    12. Detailed comparison between endocytoscopy and horizontal histology of an esophageal intraepithelial squamous cell carcinoma

      SUMMARY. Endocytoscopy allows the real-time microscopic observation of living cells. Unlike the cross-sectional images obtained by conventional histology, endocytoscopy provides cellular images in a plane parallel to the surface of the mucosa. However, there is little knowledge about the endocytoscopic diagnosis of carcinomas. Using a specimen obtained by the endoscopic submucosal dissection of an intraepithelial esophageal squamous cell carcinoma, a detailed comparison between endocytoscopic and horizontal histological images was made, revealing the similarity between the images. Sharp lateral borders between atypical and normal epithelium and differences in cellularity and the sizes and shapes of the nuclei were clearly identified by ...
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    13. Endoscopic OCT Approaches Toward Cancer Diagnosis

      A majority of human cancers originate in the epithelial tissues of the body. These include cancers in the oral cavity and pharynx, the digestive system, the respiratory system, the genital system, and the urinary system. It has been shown that early detection of these cancers can significantly improve the prognosis of affected patients. These cancers are currently diagnosed using endoscopic methods during which video imaging systems are inserted to visualize the tissue surface and guide tissue biopsies. Endoscopic optical coherence tomography (EOCT) has the potential to improve the early detection of epithelial cancers by providing high resolution, subsurface images of ...
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    14. In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers

      We report an endoscopic optical coherence tomography (OCT) system based on a Fourier Domain Mode Locked (FDML) laser, a novel data acquisition (DAQ) system with optical frequency clocking, and a high-speed spiralscanning fiber probe. The system is capable of acquiring three-dimensional (3D) in vivo ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 684708 (2008)] published Tue Feb 19, 2008.
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    15. In vitro 3D articular cartilage imaging using endoscopic spectral domain optical coherence tomography (sd-oct) with a GRIN (gradient index) lens rod based probe

      Tuqiang Xie, Yehchan Ahn, Zhongping Chen et al. In this paper, a GRIN lens rod based dynamic focusing spectral domain optical coherence tomography (OCT) system with 2D scanners is presented and is used to investigate a fresh bovine joint in vitro by 3D OCT with lateral and axial resolutions of 10 [mu]m at the speed of 8 frames/s. The experimental ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 684730 (2008)] published Mon Feb 18, 2008.
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    16. In vivo 3-D imaging of gastrointestinal tract by use of an endoscopic swept source optical coherence tomography with a microelectromechanical endoscopic rotational probe

      Jun Zhang, Jianping Su, Kenneth Chang et al. In vivo three dimensional endoscopic imaging of rabbit and human gastrointestinal tracts was demonstrated based on an endoscopic swept source optical coherence tomography (SSOCT) system. The endoscopic SSOCT system is composed of a high speed SSOCT, a fast scanning rotational microelectromechanical ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 68472Y (2008)] published Mon Feb 18, 2008.
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    17. All-fiber probe for optical coherence tomography

      Seon Young Ryu, Hae Young Choi, Jihoon Na et al. We propose an all-fiber probe for the sample arm of an optical coherence tomography (OCT) system. By forming a focusing lens directly on the tip of an optical fiber, a compact sample probe could be implemented. To achieve a long enough working distance and a high enough lateral resolution at the sam ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 68472L (2008)] published Mon Feb 18, 2008.
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    18. Anatomical optical coherence tomography: a safe and effective tool for quantitative long-term monitoring of upper airway size and shape

      J. J. Armstrong, S. Becker, R. A. McLaughlin et al. Anatomical optical coherence tomography (aOCT) is an endoscopic optical technique that enables continuous, quantitative assessment of hollow organ size and shape in three dimensions. It is a powerful alternative to X-ray computed tomography, magnetic resonance imaging, and video endoscopy for the as ... [Proc. SPIE Int. Soc. Opt. Eng. 6842, 68421N (2008)] published Fri Feb 8, 2008.
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    19. Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues

      Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues

      Yu Chen, Aaron D. Aguirre, Pei-Lin Hsiung, Shu-Wei Huang, Hiroshi Mashimo, Joseph M. Schmitt, James G. Fujimoto. Optical coherence tomography (OCT) is an emerging medical imaging technology which generates high resolution, cross-sectional images in situ, without the need for excisional biopsy. Previous clinical studies using endoscopic OCT with standard 10-15 μm axial resolution have demonstrated its ... [Opt. Express 16, 2469-2485 (2008)]

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    20. Curled optical patch cord for bending insensitive biomedical imaging endoscope

      Biomedical optical imaging technologies based on optical fibers have been of great interest because of their superiority over conventional bulk-optic counter part in size and integration. Flexible endoscope is a key component to deliver the reflected optical signal from biological tissue to the optical imaging system, such as Optical Coherence Tomography (OCT) and Fiber Confocal Microscopy (FCM). However, conventional optical fibers for the biomedical imaging endoscope have been suffered from a critical wiring problem of a fiber waveguide, which induces additional loss severely. In this work, we have shown excellent properties of holey optical fibers with low bending loss under ...

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    21. A dual-reflective electrothermal MEMS micromirror for full circumferential scanning endoscopic imaging

      This paper reports the design, fabrication and measurements of a dual-reflective, single-crystal silicon based micromirror that can perform full circumferential scanning (FCS) for endoscopic optical coherence tomography (EOCT). In the proposed FCS-EOCT probe, two optical fibers are used to deliver l ... [Proc. SPIE Int. Soc. Opt. Eng. 6885, 688508 (2008)] published Wed Feb 6, 2008.
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    457-480 of 557 « 1 2 ... 17 18 19 20 21 22 23 24 »
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