1. Articles in category: Gastroenterology

    25-48 of 552 « 1 2 3 4 5 ... 21 22 23 »
    1. €4m project to speed diagnosis of esophageal cancer

      €4m project to speed diagnosis of esophageal cancer

      The Institute of Biological and Medical Imaging at Helmholtz Zentrum München , Germany, is heading a research project entitled ”Hybrid optical and optoacoustic endoscope for esophageal tracking” or ESOTRAC . This four-year, €4 million, pan-European project will bring together engineers and physicians to develop a novel hybrid endoscopic instrument for early diagnosis and staging of esophageal cancer. The finished device is expected to reduce the number of unnecessary biopsies and, importantly, facilitate early-disease detection leading to earlier start of therapy, which will improve therapeutic efficacy over late-disease treatment and, ultimately, cost-savings for health care systems. ESOTRAC was awarded the €4 million ...

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    2. Easier diagnosis of esophageal cancer

      Easier diagnosis of esophageal cancer

      The Institute of Biological and Medical Imaging at Helmholtz Zentrum München is heading the "Hybrid optical and optoacoustic endoscope for esophageal tracking" (ESOTRAC) research project, in which engineers and physicians together develop a novel hybrid endoscopic instrument for early diagnosis and staging of esophageal cancer. The device may reduce the number of unnecessary biopsies and, importantly, facilitate early-disease detection leading to earlier start of therapy, which improves therapeutic efficacy over late-disease treatment and leads to immense cost-savings for the health care system. ESOTRAC has been awarded four million Euros from Horizon 2020, the EU framework program for research and ...

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    3. Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett's esophagus: a pilot study (with video)

      Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett's esophagus: a pilot study (with video)

      Background and Aims Angiogenesis is associated with neoplastic progression of Barrett’s esophagus (BE). Volumetric optical coherence tomography angiography (OCTA) visualizes subsurface microvasculature without exogenous contrast agents. We investigated the association of OCTA microvascular features with low-grade dysplasia (LGD) and high-grade dysplasia (HGD). Methods Fifty-two patients undergoing BE surveillance or endoscopic eradication therapies for dysplasia were imaged using volumetric OCTA and corresponding histological diagnoses obtained, to yield 97 data sets (non-dysplastic BE (NDBE): N=74; LGD: N=10; HGD: N=13). After evaluating OCTA image quality, 54 datasets (NDBE: N=35; LGD: N=8; HGD: N=11) from 32 patients ...

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    4. Feasibility of laser marking in Barrett’s esophagus with volumetric laser endomicroscopy: first-in-man pilot study

      Feasibility of laser marking in Barrett’s esophagus with volumetric laser endomicroscopy: first-in-man pilot study

      Background and Aim Volumetric laser endomicroscopy (VLE) provides a circumferential scan of the esophageal wall layers and has potential to improve detection of neoplasia in Barrett’s esophagus (BE). The novel VLE laser marking system enables direct in vivo marking of suspicious areas as identified on VLE. These laser marked areas can subsequently be targeted for biopsies. The aim was to evaluate the visibility and positional accuracy of laser marks (LMs) in different esophageal tissue types on white light endoscopy (WLE) and VLE. Methods Patients with BE with or without neoplasia underwent imaging with VLE. Protocol refinements were practiced in ...

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    5. Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter

      Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter

      Micro-optical coherence tomography (μOCT) is an advanced imaging technique that acquires a three-dimensional microstructure of biological samples with a high spatial resolution, up to 1 μm, by using a broadband light source and a high numerical aperture (NA) lens. As high NA produces a short depth of focus (DOF), extending the DOF is necessary to obtain a reasonable imaging depth. However, due to the complexity of optics and the limited space, it has been challenging to fabricate endoscopic μOCT, which is essential for clinical translation. Here, we report an endoscopic μOCT probe with an extended DOF by using a binary ...

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    6. High visibility endoprosthesis and method

      High visibility endoprosthesis and method

      An endoprosthesis, a method for imaging an endoprosthesis, a method of making an endoprosthesis involve a polymeric substrate that has been modified to have voids embedded within the substrate. The voids are sized to scatter optical radiation from within the substrate so that an optical coherence tomography (OCT) image can be obtained in which an interior region of the substrate can be easily differentiated from empty space and other structures that surround the endoprosthesis. The voids allow for OCT visualization of the polymeric substrate which may be difficult to visualize by other methods such as fluoroscopy.

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    7. Postdoc Researcher Position in integration of a micromachined endomicroscope for OCT imaging in gastroenterology

      Postdoc Researcher Position in integration of a micromachined endomicroscope for OCT imaging in gastroenterology

      The FEMTO-ST Institute (CNRS unit), associated with the Université de Bourgogne et Franche-Comté , announces the opening of a Postdoctoral Researcher position in integration of a miniature endomicroscope based on MOEMS/microoptical technologies for OCT imaging in gastroenterology. This position can start in February 2017. FEMTO-ST is one of 3 largest research institutes in France in the field of Engineering Sciences, having about 730 employees including more than 150 doctoral students. FEMTO-ST facilities offer the full access to a world-class cleanroom facility (class 10/100). The host team is focusing on MEMS and microoptics. FEMTO-ST received funding from the French government ...

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    8. Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

      Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

      Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is difficult to detect the subsurface lesions. In this research, we investigated the feasibility of a novel multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and molecular imaging. The C57BL/6J-Apc Min /J mice were imaged using OCT and FLOT, and the correlated histopathological diagnosis was obtained. Quantitative structural (scattering coefficient) and molecular (relative enzyme activity ...

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    9. Duke University Receives NIH Grant for Advanced A/LCI Systems for Improved Clinical Utility.

      Duke University Receives NIH Grant  for Advanced A/LCI Systems for Improved Clinical Utility.

      Duke University Receives a 2017 NIH Grant for $501,101 for Advanced A/LCI Systems for IMproved linical Utility. The principal investigator is Adam Wax. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. There is a critical unmet need for in vivo detection of dysplasia in patients with Barrett's esophagus (BE), a neoplastic tissue state resulting from chronic acid reflux. BE is associated with an increased risk of esophageal cancer, a disease with a high morbidity rate. Patients with BE undergo periodic endoscopic surveillance with systematic biopsy to search for ...

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    10. Volumetric laser endomicroscopy in Barrett’s esophagus: interobserver agreement for interpretation of Barrett’s esophagus and associated neoplasia among high-frequency users

      Volumetric laser endomicroscopy in Barrett’s esophagus: interobserver agreement for interpretation of Barrett’s esophagus and associated neoplasia among high-frequency users

      Abstract Background and Aims Targeting neoplasia in Barrett’s esophagus (BE) is challenging. Volumetric laser endomicroscopy (VLE) is a new imaging technique that allows for real time cross-sectional microstructure imaging that can detect BE neoplasia. The interobserver agreement among users in practice is unknown. Methods Eight high-volume users of VLE from different academic centers in the United States evaluated 120-stored VLE images blinded to the endoscopic and clinical findings. There were 30 images for each tissue type: gastric cardia, esophageal squamous mucosa, non-neoplastic BE, and neoplastic BE. Each image with BE had corresponding histology confirming the tissue diagnosis. Each normal ...

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    11. Micro-Tech LumiScan Imaging System 510(k) Clearance

      Micro-Tech LumiScan Imaging System 510(k) Clearance

      We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions ...

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      Mentions: FDA Micro-Tech
    12. NinePoint Medical Announces Substantial Hospital Reimbursement Increase for Procedures Using the NvisionVLE Imaging System with Real-time Targeting

      NinePoint Medical Announces Substantial Hospital Reimbursement Increase for Procedures Using the NvisionVLE Imaging System with Real-time Targeting

      NinePoint Medical, Inc., a transformative medical device company pioneering the use of an advanced imaging platform for gastrointestinal applications, announced today that the U.S. Centers for Medicare & Medicaid Services (CMS) has published its 2017 final fee schedule. The annual update includes a material increase to the reimbursement rate for CPT Code 43252 1 ( upper GI endoscopy with optical endomicroscopy ), used for esophageal procedures using the NvisionVLE Imaging System with Real-time Targeting. According to the final 2017 CMS fee schedule, starting January 1, 2017, the reimbursement rate for CPT code 43252 in the hospital out-patient setting increases 131% from $1 ...

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    13. Volumetric Mapping of Barrett’s Esophagus and Dysplasia With en face Optical Coherence Tomography Tethered Capsule

      Volumetric Mapping of Barrett’s Esophagus and Dysplasia With en face Optical Coherence Tomography Tethered Capsule

      To the Editor: Dysplasia in Barrett’s Esophagus (BE) is patchy ( 1 ) and sometimes missed by random biopsies. Optical coherence tomography (OCT) can image large areas of the esophagus; however, slow imaging speeds in earlier studies limited visualization to cross-sections. Cross-sectional OCT detected high-grade dysplasia with sensitivity / specificity of ~80 % ( 2 , 3 ). Tethered OCT capsules were demonstrated for cross-sectional imaging in unsedated screening to detect BE ( 4 , 5 ). Our group recently developed ultrahigh-speed OCT for en face and angiographic imaging, using micromotor probes in patients ( 6 , 7 ) and large field-of-view tethered capsule devices in swine ( 8 ). Narrow-band imaging (NBI) visualizes ...

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    14. Endoscopic optical coherence tomography using compressive sensing

      Endoscopic optical coherence tomography using compressive sensing

      Conventionally endoscopic OCT images are reconstructed by uniform sampling in both axial and transverse direction of the image. To shorten the scanning time and reduce the acquisition data, we propose to sparsely sample the axial scans and use compressive sensing (CS) to reconstruct the full endoscopic OCT image with randomly chosen axial scans that are much less than conventional Nyquist criteria requirement. And we study the ratio of sparse sampling numerically and experimentally that are required to reconstruct acceptable OCT images. We demonstrate that the OCT image acquisition time can be significantly reduced because of much less acquired data.

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    15. Miniaturization of plastic lens by injection molding for disposable endoscopie optical coherence tomography system

      Miniaturization of plastic lens by injection molding for disposable endoscopie optical coherence tomography system

      Minimally invasive robotic surgery required disposable endoscopie optical coherence tomography (OCT) for high-resolution deep tissue imaging and cross-contamination prevention. Here, we developed a miniaturized plastic lens by injection molding for developing a disposable endoscopie optical coherence tomography system for the first time. Injection molding provided low-cost and high-production rate to produce a disposable plastic lens and enabled the miniaturization of plastic lens. Transmittance and curvature of the plastic lens was measured. The plastic lens was integrated with an endoscopie OCT system, and the images of human-skin and microspheres embedded in agarose gel were captured. We are currently trying to integrate ...

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      Mentions: Ki Hean Kim
    16. Identification of Volumetric Laser Endomicroscopy features predictive for early neoplasia in Barrett’s esophagus using high-quality histological correlation

      Identification of Volumetric Laser Endomicroscopy features predictive for early neoplasia in Barrett’s esophagus using high-quality histological correlation

      Background and aims volumetric laser endomicroscopy (VLE) provides a circumferential scan that enables the visualization of subsurface layers of the esophageal wall at 7 μm resolution. The aims of this study were to identify VLE features ofBarrett’s esophagus (BE) neoplasia and to develop a VLE prediction score. Methods A database of VLE images from endoscopic resection specimens, precisely correlated with histology, from BE patients +/- neoplasia was used. Features potentially predictive for early BE neoplasia were identified by unblinded evaluation of 25 VLE-histology images. In a learning phase, 20 VLE images with or without BE neoplasia were scored by 2 ...

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    17. Common-path optical coherence tomography using a microelectromechanical-system-based endoscopic probe

      Common-path optical coherence tomography using a microelectromechanical-system-based endoscopic probe

      This paper presents a common-path (CP) swept-source optical coherence tomography (SSOCT) system based on a special endoscopic probe design with an in-line internal reflection as the reference and a two-axis electrothermal microelectromechanical system mirror for image scanning. The rear surface of a gradient reflective index (GRIN) lens inside the probe is set as the reference reflection plane. The length of the GRIN lens is optimized to eliminate the artifacts in SSOCT images successfully. Doppler OCT is also demonstrated based on the CP endoscopic probe. The diameter of the probe is only 2.5 mm, so it can be easily inserted ...

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    18. In vivo endoscopic Doppler optical coherence tomography imaging of the colon

      In vivo endoscopic Doppler optical coherence tomography imaging of the colon

      Background and Objective Colorectal cancer (CRC) remains the second deadliest cancer in the United States. Several screening methods exist; however, detection of small polyps remains a challenge. Optical coherence tomography (OCT) has been demonstrated to be capable of detecting lesions as small as 1 mm in the mouse colon, but detection is based on measuring a doubling of the mucosa thickness. The colon microvasculature may be an attractive biomarker of early tumor development because tumor vessels are characterized by irregular structure and dysfunction. Our goal was to develop an endoscopic method of detecting and segmenting colon vessels using Doppler OCT ...

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    19. Optical Coherence Tomography: Clinical Applications in Gastrointestinal Endoscopy (Book Chapter)

      Optical Coherence Tomography: Clinical Applications in Gastrointestinal Endoscopy (Book Chapter)

      Optical coherence tomography (OCT) is a high-resolution imaging modality that uses principles of light interferometry. It has achieved clinical application in several other specialties such as ophthalmology and cardiology where its high resolution and deeper penetration into the surface permits much more detailed examination of the mucosa. In the field of gastroenterology, the technology has evolved through several iterations beginning with a focal magnifying imaging technique and evolving into currently a widefield imaging modality that can scan a relatively large area of mucosa with high resolution. OCT has been used to detect dysplasia in Barrett’s esophagus, differentiate between inflammatory ...

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    20. University of Washington Receives NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 2D Pathology of Pancreas

      University of Washington Receives NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 2D Pathology of Pancreas

      University of Washington Receives a 2016 NIH Grant for $235,226 for Needle Biopsy Preservation and Preparation for Rapid 2D Pathology of Pancreas. The principal investigator is Eric Seibel. The program began in 2014 and ends in 2017. Below is a summary of the proposed work. There are over three million needle biopsies performed every year in the USA, typically for the diagnosis of breast, prostate, thyroid, lung, liver, and pancreatic cancers. Because needle biopsies are less invasive than surgical biopsies, they are much more cost-effective. However, a major limitation for all needle biopsies are that the pathologist or cytologist ...

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    21. The new kid on the block for advanced imaging in Barrett’s esophagus: a review of volumetric laser endomicroscopy

      The new kid on the block for advanced imaging in Barrett’s esophagus: a review of volumetric laser endomicroscopy

      Advanced imaging techniques used in the management of Barrett’s esophagus include electronic imaging enhancement (e.g. narrow band imaging, flexible spectral imaging color enhancement, and i-Scan), chromoendoscopy, and confocal laser endomicroscopy. Electronic imaging enhancement is used frequently in daily practice, but use of the other advanced technologies is not routine. High-definition white light endoscopy and random four quadrant biopsy remain the standard of care for evaluation of Barrett’s esophagus; this is largely due to the value of advanced imaging technologies not having been validated in large studies or in everyday practice. A new advanced imaging technology called volumetric ...

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    22. Volumetric laser endomicroscopy can target neoplasia not detected by conventional endoscopic measures in long segment Barrett’s esophagus

      Volumetric laser endomicroscopy can target neoplasia not detected by conventional endoscopic measures in long segment Barrett’s esophagus

      Methods and study aims: The incidence of esophageal cancer is rising despite increased surveillance efforts. Volumetric laser endomicroscopy (VLE) is a new endoscopic imaging tool that can allow for targeted biopsy of neoplasia in Barrett’s esophagus. We report a series of 6 patients with long-segment Barrett’s esophagus ( > 3 cm), who underwent a session of endoscopy with volumetric laser endomicroscopy, after a separate prior session of standard high-definition endoscopy with narrow band imaging (NBI) and random biopsies that did not reveal neoplasia. In all six patients, the first endoscopy was the index endoscopy diagnosing the Barrett’s esophagus. All ...

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    23. Toward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomography

      Toward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomography

      The mucosal microanatomy of the large intestine is characterized by the presence of crypts of Lieberkühn, which is associated predominantly with goblet cells. Such cellular-level intestinal microstructures undergo morphological changes during the progression of bowel diseases, such as colon cancer or ulcerative colitis. As an indicator of gastric cancers, intestinal metaplasia in the large intestine is characterized by the appearance of goblet cells in gastric epithelium, and therefore, visualization of intestinal microstructure changes in cross-sectional view, particularly in vivo, in a highspeed fashion would assist early disease diagnosis and its treatment. In this paper, we investigated the capability of ...

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    24. Massachusetts General Hospital Receives a 2016 NIH Grant for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy

      Massachusetts General Hospital Receives a 2016 NIH Grant for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy

      Massachusetts General Hospital Receives a 2016 NIH Grant for $573,805 for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy. The principal investigator is Guillermo Tearney. The program began in $2014 and ends in 2019. Below is a summary of the proposed work. Celiac disease (CD) is an autoimmune response to gluten proteins that affects 3M people in the US and 50M worldwide. These proteins incite an inflammatory reaction that eventually destroys the absorptive villi in the duodenum, resulting in gastrointestinal symptoms, malabsorption, malnutrition, and an increased incidence of other autoimmune diseases, diabetes, and cancer. A definitive diagnosis of CD is ...

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