1. Articles in category: Gastroenterology

    1-24 of 501 1 2 3 4 ... 19 20 21 »
    1. NinePoint Medical Announces Completion of Clinical Registry and Publication of Results at DDW 2016

      NinePoint Medical Announces Completion of Clinical Registry and Publication of Results at DDW 2016

      NinePoint Medical, Inc., a transformative medical device company pioneering the use of an advanced imaging platform for gastrointestinal applications, announced today that it has completed the primary phase of its Registry for High Resolution Optical Imaging of the Esophagus Using the NvisionVLE ® Imaging System. Results from the registry’s interim analysis will be presented in 11 scientific abstracts accepted to Digestive Disease Week ® (DDW) 2016, to be held May 21-24 in San Diego, California.

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    2. Bimodal endoscopic probe combining white-light microscopy and optical coherence tomography

      Bimodal endoscopic probe combining white-light microscopy and optical coherence tomography

      We present a novel bimodal endoscopic imaging probe that can simultaneously provide full-field white-light video microscopy and confocal optical coherence tomography (OCT) depth scans. The two modalities rely on spectrally separated optical paths that run partially in parallel through a micro-optical bench system, which has a cross-section of only 2    mm × 2.76    mm and is realized via standard silicon micromachining techniques. With a numerical aperture of 0.061, the video modality has a resolution and field of view of 9.3 and 1240    μm × 1080    μm , respectively. The resolution is limited by the pixel spacing of the coherent fiber ...

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    3. Massachusetts Institute of Technology Receives Grant for Optical Biopsy Using Optical Coherence Tomography

      Massachusetts Institute of Technology Receives Grant for Optical Biopsy Using Optical Coherence Tomography

      Massachusetts Institute of Technology Receives a 2016 NIH Grant for $288,576 for Optical Biopsy Using Optical Coherence Tomography. The principal investigator is James Fujimoto. The program began in 1997 and ends in 2019. Below is a summary of the proposed work. This is a multidisciplinary collaboration between investigators at the Massachusetts Institute of Technology and the VA Boston Healthcare System integrating imaging technology research, clinical imaging studies, medical device development and animal imaging studies. Esophageal cancer is a lethal malignancy, with a five-year survival rate of 16%. Barrett's esophagus (BE) and dysplasia are precursors to esophageal adenocarcinoma (EAC ...

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    4. NinePoint Medical Announces FDA 510(k) Clearance of a Real-Time Targeting Feature for the NvisionVLE® Imaging System and the First Clinical Cases in the U.S.

      NinePoint Medical Announces FDA 510(k) Clearance of a Real-Time Targeting Feature for the NvisionVLE® Imaging System and the First Clinical Cases in the U.S.

      NinePoint Medical, Inc., a transformative medical device company pioneering the use of a real-time imaging platform for gastrointestinal applications, announced today that it has received U.S. Food and Drug Administration (FDA) 510(k) clearance to market its Real-time Targeting™ feature for its flagship product, the NvisionVLE ® Imaging System. In addition, the first procedures with this new system were performed at Beth Israel Deaconess Medical Center in Boston, Massachusetts. The NvisionVLE Imaging System employs proprietary Optical Coherence Tomography (OCT) technology allowing physicians to perform a Volumetric Laser Endomicroscopy (VLE) procedure that produces real-time, high-resolution cross-sectional images. This system enables gastroenterologists ...

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    5. NinePoint Medical Strengthens Sales Leadership by appointing John Temple as Vice President of Sales

      NinePoint Medical Strengthens Sales Leadership by appointing John Temple as Vice President of Sales

      NinePoint Medical, Inc., a transformative medical device company that is pioneering the clinical use of a real-time imaging platform based upon a proprietary optical coherence tomography (OCT) technology, announced today the appointment of John Temple as Vice President of Sales. Mr. Temple reports directly to NinePoint Medical’s President and CEO, Christopher R. von Jako, Ph.D. “We are delighted to welcome such an accomplished sales executive to the NinePoint Medical team. Not only does John bring tremendous commercial leadership experience, but also in-depth gastroenterology industry knowledge and relationships,” said Dr. von Jako. “John’s exceptional track record will be ...

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    6. Optical coherence tomography (OCT) prior to peroral endoscopic myotomy (POEM) reduces procedural time and bleeding: a multicenter international collaborative study

      Optical coherence tomography (OCT) prior to peroral endoscopic myotomy (POEM) reduces procedural time and bleeding: a multicenter international collaborative study

      Background Per-oral endoscopic myotomy (POEM) has emerged as an endoscopic treatment of achalasia. There are no pre-procedural imaging modalities to predict the safest and the most efficacious approach. Aim To evaluate the use of optimal coherence tomography (OCT) in providing a pre-procedural esophageal assessment. Methods Patients undergoing POEM from July 2013 to November 2015 were captured in a multicenter, international registry. Patients who underwent OCT pre-POEM (“OCT arm”) were compared to patients without pre-POEM OCT (“control arm”). OCT images were assessed for the degree of vascularity and the thickness of the circular muscular layer, and an approach was determined. Results ...

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    7. Spectrally encoded miniature endoscopic imaging probe

      Spectrally encoded miniature endoscopic imaging probe

      A spectrally encoded endoscopic probe having high resolution and small diameter comprising at least one flexible optical fiber; an energy source; a grating through which said energy is transmitted such that the energy spectrum is dispersed; a lens for focusing the dispersed energy spectrum onto a sample such that the impingement spot for each wavelength is a separate position on the sample, the wavelength spectrum defining a wavelength encoded axis; means for mechanically scanning the sample with focused energy in a direction perpendicular to the wavelength encoded axis; a means for receiving energy reflected from the sample; and, a means ...

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    8. Method for identifying malignancies in barrett's esophagus using white light endoscopy

      Method for identifying malignancies in barrett's esophagus using white light endoscopy

      A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume T.sub.HB and oxygenation SO.sub.2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation ...

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    9. Optical coherence tomography imaging of colonic crypts in a mouse model of colorectal cancer

      Optical coherence tomography imaging of colonic crypts in a mouse model of colorectal cancer

      Aberrant crypt foci (ACF) are abnormal epithelial lesions that precede development of colonic polyps. As the earliest morphological change in the development of colorectal cancer, ACF is a highly studied phenomenon. The most common method of imaging ACF is chromoendoscopy using methylene blue as a contrast agent. Narrow- band imaging is a contrast-agent-free modality for imaging the colonic crypts. Optical coherence tomography (OCT) is an attractive alternative to chromoendoscopy and narrow-band imaging because it can resolve the crypt structure at sufficiently high sampling while simultaneously providing depth-resolved data. We imaged in vivo the distal 15 mm of colon in the ...

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    10. In vivo endoscopic Doppler optical coherence tomography imaging of mouse colon

      In vivo endoscopic Doppler optical coherence tomography imaging of mouse colon

      Colorectal cancer remains the second deadliest cancer in the United States, despite the high sensitivity and specificity of colonoscopy and sigmoidoscopy. While these standard imaging procedures can accurately detect medium and large polyps, some studies have shown miss rates up to 25% for polyps less than 5 mm in diameter. An imaging modality capable of detecting small lesions could potentially improve patient outcomes. Optical coherence tomography (OCT) has been shown to be a powerful imaging modality for adenoma detection in a mouse model of colorectal cancer. While previous work has focused on analyzing the structural OCT images based on thickening ...

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    11. Confocal Laser Endomicroscopy and Optical Coherence Tomography for Diagnosing ILD

      Confocal Laser Endomicroscopy and Optical Coherence Tomography for Diagnosing ILD

      Often, assessing a classifying diagnosis in patients with interstitial lung disease provides a diagnostic challenge. Currently HRCT, endoscopic or surgical video assisted thoracoscopic surgery (VATS) assessment including lung biopsies are diagnostic tools for patients with suspected ILD. However, tissue acquisition is associated with morbidity in these patients with an already compromised pulmonary function. In clinical practice this results in the fact that only a minor part of patients with an indication for tissue acquisition are actually undergoing biopsies. The aim of this study is to determine ILD-characteristics on imagign collected with minimal invasive novel optical techniques, to examine whether the ...

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    12. Tethered capsule detects GI tract disease

      Tethered capsule detects GI tract disease

      The diagnosis and subsequent treatment of many diseases of the upper gastrointestinal tract often call for endoscopic examination. Unfortunately, this is typically expensive, uncomfortable, requires patient sedation and only provides limited information on surface tissues. Subsequent biopsies can provide additional information, but only from limited sample sites. This can be especially problematic when attempting to diagnose diseases with patchy presentations, such as Barrett's oesophagus – in which oesophageal tissues change to resemble those that line the intestine.

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    13. Advances in upper gastrointestinal endoscopy

      Advances in upper gastrointestinal endoscopy

      The rapidly moving technological advances in gastrointestinal endoscopy have enhanced an endoscopist’s ability to diagnose and treat lesions within the gastrointestinal tract. The improvement in image quality created by the advent of high-definition and magnification endoscopy, alongside image enhancement, produces images of superb quality and detail that empower the endoscopist to identify important lesions that have previously been undetectable. Additionally, we are now seeing technologies emerge, such as optical coherence tomography and confocal laser endomicroscopy, that allow the endoscopist to visualize individual cells on a microscopic level and provide a real time, in vivo histological assessment. Within this article ...

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    14. Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts

      Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts

      The development of colorectal cancer in the azoxymethane-induced mouse model can be observed by using a miniaturized optical coherence tomography (OCT) imaging system. This system is uniquely capable of tracking disease development over time, allowing for the monitoring of morphological changes in the distal colon due to tumor development and the presence of lymphoid aggregates. By using genetically engineered mouse models deficient in Interleukin 6 (IL-6) and Smad family member 3 (Smad3), the role of inflammation on tumor development and the immune system can be elucidated. Smad3 knockout mice develop inflammatory response, wasting, and colitis associated cancer while deficiency of ...

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    15. Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy

      Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy

      Optical coherence tomography (OCT) is an optical diagnostic modality that can acquire cross-sectional images of the microscopic structure of the esophagus, including Barrett’s esophagus (BE) and associated dysplasia. We developed a swallowable tethered capsule OCT endomicroscopy (TCE) device that acquires high-resolution images of entire gastrointestinal (GI) tract luminal organs. This device has a potential to become a screening method that identifies patients with an abnormal esophagus that should be further referred for upper endoscopy. Currently, the characterization of the OCT-TCE esophageal wall data set is performed manually, which is time-consuming and inefficient. Additionally, since the capsule optics optimally focus ...

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    16. Optimal operational conditions for supercontinuum-based ultrahigh-resolution endoscopic OCT imaging

      Optimal operational conditions for supercontinuum-based ultrahigh-resolution endoscopic OCT imaging

      We investigated the optimal operational conditions for utilizing a broadband supercontinuum (SC) source in a portable 800 nm spectral-domain (SD) endoscopic OCT system to enable high resolution, high-sensitivity, and high-speed imaging in vivo . A SC source with a 3-dB bandwidth of ∼ 246     nm was employed to obtain an axial resolution of ∼ 2.7     μm (in air) and an optimal detection sensitivity of ∼ − 107     dB with an imaging speed up to 35 frames/s (at 70 k A-scans/s). The performance of the SC-based SD-OCT endoscopy system was demonstrated by imaging guinea pig esophagus in vivo , achieving image quality comparable to ...

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    17. NinePoint, Under New Leadership, Bags $31M More For Imaging Tech

      NinePoint, Under New Leadership, Bags $31M More For Imaging Tech

      NinePoint Medical looks to have added roughly $31 million in financing to back its medical imaging technology. According to a regulatory filing , the Bedford, MA-based company has raised about $30.7 million in new venture funding and could add about $10 million more to the pot. The filing lists three investors: they appear to be founding backers Third Rock Ventures and Prospect Venture Partners, and relative newcomer Corning (NYSE: GLW ), which began investing in NinePoint when the company raised a $34 million Series B round in March 2014. Members of each of the three firms—Mark Levin (Third Rock), Russell ...

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    18. Rotational distortion correction in endoscopic optical coherence tomography based on speckle decorrelation

      Rotational distortion correction in endoscopic optical coherence tomography based on speckle decorrelation

      We present a new technique for the correction of nonuniform rotation distortion in catheter-based optical coherence tomography (OCT), based on the statistics of speckle between A-lines using intensity-based dynamic light scattering. This technique does not rely on tissue features and can be performed on single frames of data, thereby enabling real-time image correction. We demonstrate its suitability in a gastrointestinal (GI) balloon-catheter OCT system, determining the actual rotational speed with high temporal resolution, and present corrected cross-sectional and en face views showing significant enhancement of image quality.

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    19. Feasibility of optical coherence tomography for the evaluation of Barrett's mucosa buried underneath esophageal squamous epithelium

      Feasibility of optical coherence tomography for the evaluation of Barrett's mucosa buried underneath esophageal squamous epithelium

      Objectives The evaluation of Barrett's glands buried underneath esophageal squamous epithelium becomes increasingly important to achieve curative treatments. However, clinically available endoscopies have critical limitations in depicting the subsurface structure, resulting in non-curative treatments. Optical coherence tomography (OCT) can acquire a high-resolution cross-sectional image, equivalent to an ‘optical biopsy’. We aimed to assess the feasibility of the in vivo use of probe-type OCT imaging to evaluate Barrett's mucosa buried underneath esophageal squamous epithelium Methods We conducted a single-center prospective study with 14 consecutive patients with Barrett's adenocarcinoma from 2008 to 2014. The enrolled patients were examined by ...

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    20. Advances in the management of Barrett’s esophagus and early esophageal adenocarcinoma

      Advances in the management of Barrett’s esophagus and early esophageal adenocarcinoma

      The incidence of esophageal adenocarcinoma (EAC) has markedly increased in the United States over the last few decades. Barrett’s esophagus (BE) is the most significant known risk factor for this malignancy. Theoretically, screening and treating early BE should help prevent EAC but the exact incidence of BE and its progression to EAC is not entirely known and cost-effectiveness studies for Barrett’s screening are lacking. Over the last few years, there have been major advances in our understanding of the epidemiology, pathogenesis and endoscopic management of BE. These developments focus on early recognition of advanced histology and endoscopic treatment ...

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    21. The use of optical imaging techniques in the gastrointestinal tract

      The use of optical imaging techniques in the gastrointestinal tract

      With significant advances in the management of gastrointestinal disease there has been a move from diagnosing advanced pathology, to detecting early lesions that are potentially amenable to curative endoscopic treatment. This has required an improvement in diagnostics, with a focus on identifying and characterising subtle mucosal changes. There is great interest in the use of optical technologies to predict histology and enable the formulation of a real-time in vivo diagnosis, a so-called ‘optical biopsy’. The aim of this review is to explore the evidence for the use of the current commercially available imaging techniques in the gastrointestinal tract.

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    22. ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus

      ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus

      Barrett’s esophagus (BE) is among the most common conditions encountered by the gastroenterologist. In this document, the American College of Gastroenterology updates its guidance for the best practices in caring for these patients. These guidelines continue to endorse screening of high-risk patients for BE; however, routine screening is limited to men with reflux symptoms and multiple other risk factors. Acknowledging recent data on the low risk of malignant progression in patients with nondysplastic BE, endoscopic surveillance intervals are attenuated in this population; patients with nondysplastic BE should undergo endoscopic surveillance no more frequently than every 3–5 years. Neither ...

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    23. Online Tracking and Retargeting with Applications to Optical Biopsy in Gastrointestinal Endoscopic Examinations

      Online Tracking and Retargeting with Applications to Optical Biopsy in Gastrointestinal Endoscopic Examinations

      With recent advances in biophotonics, techniques such as narrow band imaging, confocal laser endomicroscopy, fluorescence spectroscopy, and optical coherence tomography, can be combined with normal white-light endoscopes to provide in vivo microscopic tissue characterisation, potentially avoiding the need for offline histological analysis. Despite the advantages of these techniques to provide online optical biopsy in situ , it is challenging for gastroenterologists to retarget the optical biopsy sites during endoscopic examinations. This is because optical biopsy does not leave any mark on the tissue. Furthermore, typical endoscopic cameras only have a limited field-of-view and the biopsy sites often enter or exit the ...

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    24. Monitoring disposition of tethered capsule endoscope in esophagus

      Monitoring disposition of tethered capsule endoscope in esophagus

      A scanning flexible endoscope includes a tether attached to a capsule. The tether controls a disposition of the capsule within a body lumen such as the esophagus. A scanning device in the capsule optically scans the adjacent tissue on the inside surface of the body lumen as the capsule is moved axially through the body lumen. A non-contact sensor responds to indicia on the tether to measure a relative position of the tether and the capsule in the body lumen. The indicia can be analog or digital in form and the sensor can be either magnetic, or optical. A wiper ...

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    1-24 of 501 1 2 3 4 ... 19 20 21 »
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