1. Articles in category: Gastroenterology

    1-24 of 470 1 2 3 4 ... 18 19 20 »
    1. Recent development of optical coherence tomography for preoperative diagnosis of esophageal malignancies

      Recent development of optical coherence tomography for preoperative diagnosis of esophageal malignancies

      Endoscopic diagnosis with histological evidence is necessary to decide the best strategy for treating esophageal squamous cell carcinoma and Barrett’s-associated neoplasia, and the recent development of endoscopic technologies have made possible real-time information of malignant hallmarks. We focused on the development of optical coherence tomography (OCT), the only technology that can depict real-time cross-sectional images with high resolution. With the improvements in image resolution, acquisition rate and demonstrable area of three-dimensional devices with Doppler capability, OCT imaging was shown to enable visualization of structural/ functional alterations in the mucosal/submucosal tissue of the esophagus, resulting in more accurate preoperative ...

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    2. Finding a needle in a haystack: use of volumetric laser endomicroscopy in targeting focal dysplasia in long-segment Barrett’s esophagus

      Finding a needle in a haystack: use of volumetric laser endomicroscopy in targeting focal dysplasia in long-segment Barrett’s esophagus

      A 64-year-old man underwent esophagoscopy 15 months earlier, which diagnosed long-segment Barrett’s esophagus. Examination of random biopsy specimens yielded a diagnosis of intestinal metaplasia, with 1 biopsy specimen as indefinite for dysplasia. Two subsequent esophagoscopies were performed 6 months apart, and random biopsy specimens were negative for dysplasia. The patient was referred for volumetric laser endomicroscopy (VLE) (NVisionVLE, NinePoint Medical, Cambridge, Mass). At esophagoscopy, high-definition white-light endoscopy showed a 7-cm segment of flat salmon-colored mucosa (Prague class C6M7) ( A ).

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    3. Detection of buried Barrett’s glands after radiofrequency ablation with volumetric laser endomicroscopy

      Detection of buried Barrett’s glands after radiofrequency ablation with volumetric laser endomicroscopy

      Background and Aims The prevalence and clinical relevance of buried Barrett’s glands (BB) after radiofrequency ablation (RFA) in Barrett’s esophagus (BE) are debated. Recent optical coherence tomography studies demonstrated a high prevalence of BBs. Direct histological correlation, however, has been lacking. Volumetric laser endomicroscopy (VLE) is a second-generation optical coherence tomography system capable of scanning a large surface of the esophageal wall layers with low-power microscopy resolution. The aim was to evaluate whether post-RFA subsquamous glandular structures (SGSs), detected with VLE, actually correspond to BBs by pursuing direct histological correlation with VLE images. Methods In vivo VLE was ...

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    4. Barrett's Esophagus: Advanced Imaging Options For Early Cancer Detection

      Barrett's Esophagus: Advanced Imaging Options For Early Cancer Detection

      This Video describes the basic approach to endoscopic inspection of Barrett's esophagus. It Focuses on new imaging technologies that increase our ability to detect precancerous or cancerous changes and thus allow us to better target treatment to these areas. For more information on Barrett's Esophagus, visit: http://www.mayoclinic.org/diseases-co...

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    5. MGH Receives NIH Grant To Study Natural History of Barrett's Esophagus Using Capsule Endomicroscopy

      MGH Receives NIH Grant To Study Natural History of Barrett's Esophagus Using Capsule Endomicroscopy

      Massachusetts General Hospital Receives a 2015 NIH Grant for $472,417 To Study Natural History of Barrett's Esophagus Using Capsule Endomicroscopy. The program began in 2014 and ends in 2019. Below is a summary of the proposed work. Barrett's esophagus (BE) is a condition where normal esophageal squamous mucosa changes to metaplastic columnar mucosa in response to chronic acid reflux. BE can progress to esophageal adenocarcinoma (EAC), a prevalent (~12,000 cases per year) and deadly cancer (~15% 5-year mortality rate). Current BE management strategies of anti-reflux therapy, endoscopic screening, and regular endoscopic biopsy surveillance and ablation therapy ...

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    6. Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection for Endoscopic Therapy of Barrett’s Esophagus-related Neoplasia

      Endoscopic Mucosal Resection and Endoscopic Submucosal Dissection for Endoscopic Therapy of Barrett’s Esophagus-related Neoplasia

      Barrett’s esophagus (BE) is characterized by a change in the lining of the esophagus from stratified squamous epithelium to a metaplastic columnar epithelium (IM) that has a low, but real, malignant potential. The progression of BE to carcinoma occurs in a stepwise fashion from IM through dysplasia (low grade to high grade [HGD]). Endoscopic surveillance is recommended for patients with BE to detect and manage

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    7. Miniaturized magnetic-driven scanning probe for endoscopic optical coherence tomography

      Miniaturized magnetic-driven scanning probe for endoscopic optical coherence tomography

      We designed and implemented a magnetic-driven scanning (MDS) probe for endoscopic optical coherence tomography (OCT). The probe uses an externally-driven tiny magnet in the distal end to achieve unobstructed 360-degree circumferential scanning at the side of the probe. The design simplifies the scanning part inside the probe and thus allows for easy miniaturization and cost reduction. We made a prototype probe with an outer diameter of 1.4 mm and demonstrated its capability by acquiring OCT images of ex vivo trachea and artery samples from a pigeon. We used a spectrometer-based Fourier-domain OCT system and the system sensitivity with our ...

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    8. Micro-Tech Developing a SS-OCT Endoscopic System for Gastroenterology

      Micro-Tech Developing a SS-OCT Endoscopic System for Gastroenterology

      Micro-Tech an medical company in China established in 1999 is developing a SS-OCT endoscopic system. The system was shown at DDW 2015 and was developed by Jiefeng Xi a Principle Engineer at Micro-Tech and former PhD student at Johns Hopkins who graduated in July 2014. For more information click HERE .

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    9. Optical coherence tomography after POEM

      Optical coherence tomography after POEM

      Amy Tyberg, MD, from Weill Cornell Medical College in New York, New York, USA presents this video case “Endoscopic optical coherence tomography as a tool to evaluate successful myotomy after a peroral endoscopic myotomy.” This case describes a 51-year-old woman with achalasia who underwent a per-oral endoscopic myotomy (POEM) with complete resolution of her symptoms post-procedure. A repeat endoscopy with optical coherence tomography (OCT) was performed post-procedure to confirm successful myotomy.  

      OCT is an exciting new technology that allows for two-dimensional, cross-sectional imaging of the esophageal wall in vivo. This technology has been well studied in Barrett’s esophagus  as ...

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    10. Optical coherence tomography and intravascular ultrasound evaluation of cardiac allograft vasculopathy with and without intimal neovascularization

      Optical coherence tomography and intravascular ultrasound evaluation of cardiac allograft vasculopathy with and without intimal neovascularization

      Aims Neovascularization is closely associated with plaque progression in non-heart transplantation subjects; on the other hand, cardiac allograft vasculopathy causes unfavourable outcomes. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) can provide microscopic assessment in vivo . The aim of this study was to investigate the impact of neovascularization on intimal proliferation. Methods and results Both IVUS and OCT were attempted in 45 consecutive patients during annual catheterization after heart transplantation. There were 115 vessels [28 vessels were catheterized within 8 weeks of heart transplantation (baseline)]. IVUS analysis assessed vessel, luminal, and intimal (vessel-lumen) volume using Simpson's method. Qualitative parameters ...

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    11. Emerging optical methods for surveillance of Barrett's oesophagus

      Emerging optical methods for surveillance of Barrett's oesophagus

      The rapid rise in incidence of oesophageal adenocarcinoma has motivated the need for improved methods for surveillance of Barrett's oesophagus. Early neoplasia is flat in morphology and patchy in distribution and is difficult to detect with conventional white light endoscopy (WLE). Light offers numerous advantages for rapidly visualising the oesophagus, and advanced optical methods are being developed for wide-field and cross-sectional imaging to guide tissue biopsy and stage early neoplasia, respectively. We review key features of these promising methods and address their potential to improve detection of Barrett's neoplasia. The clinical performance of key advanced imaging technologies is ...

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    12. New Clinical Data Using the NvisionVLE® Imaging System to be Presented at Digestive Disease Week® 2015

      New Clinical Data Using the NvisionVLE® Imaging System to be Presented at Digestive Disease Week® 2015

      NinePoint Medical, Inc. , an emerging leader in the development of medical devices for advanced imaging, today announced that new clinical data relating to its proprietary NvisionVLE ® Imaging System, will be presented in a series of oral and poster presentations during Digestive Disease Week ® (DDW ® ) 2015. The annual meeting will take place May 16-19th in Washington, DC. The schedule for scientific presentations related to advanced optical coherence tomography (OCT) and the NvisionVLE ® Imaging System at DDW 2015 is provided below. SATURDAY, May 16, 2015 Three posters will be presented on Saturday, May 16 at 9:30am in Hall C of Walter ...

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    13. Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos)

      Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos)

      Background Volumetric laser endomicroscopy (VLE) produces high-resolution, cross-sectional surface, and subsurface images for detecting neoplasia, targeting biopsies, and guiding real-time treatment. Objective To evaluate the safety and feasibility of the Nvision VLE system. Design Prospective, multicenter study. Setting Tertiary-care medical centers. Patients One hundred patients with suspected Barrett’s esophagus, including 52 patients with prior endotherapy. Interventions The first-generation Nvision VLE Imaging System, a balloon-centered, rotating optical probe provided images of the mucosa and submucosa through a 6-cm segment length and 360° scan of the distal esophagus. Main Outcome Measurements Acquisition of a complete, 6-cm scan from the distal esophagus ...

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    14. Volumetric laser endomicroscopy in Barrett's esophagus: a feasibility study on histological correlation

      Volumetric laser endomicroscopy in Barrett's esophagus: a feasibility study on histological correlation

      Volumetric laser endomicroscopy (VLE) is a novel balloon-based optical coherence tomography (OCT) imaging technique that may improve detection of early neoplasia in Barrett's esophagus (BE). Most OCT studies lack a direct correlation between histology and OCT images. The aim is to investigate the optimal approach for achieving one-to-one correlation of ex-vivo VLE images of endoscopic resection (ER) specimens with histology. BE patients with and without early neoplasia underwent ER after delineating areas with electrocoagulation markers (ECM). After ER, specimens underwent additional ex-vivo marking with several different markers (ink, pin, Gold Probe) followed by ex-vivo VLE scanning. ER specimens were ...

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    15. Feature Of The Week 5/10/2015: Laser Tissue Coagulation and Concurrent Optical Coherence Tomography Through a Double-Clad Fiber Coupler

      Feature Of The Week 5/10/2015: Laser Tissue Coagulation and Concurrent Optical Coherence Tomography Through a Double-Clad Fiber Coupler

      This work is the result of a collaboration between researchers from Professor Caroline Boudoux’s team from Polytechnique Montréal (Canada) and Professor Brett E. Bouma’s team at the Wellman Center for Photomedicine (MGH, Boston). The goal is to assess whether OCT-guided biopsy could benefit from the use of double-clad fiber (DCF). DCF allows a single channel fiber-optic probe to be shared: i.e. the core propagating the OCT signal while the inner cladding delivers the coagulation laser light used for laser marking. DCF is herein used in conjunction with a double-clad fiber coupler (DCFC) to enable simultaneous and ...

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    16. Ultra-thin and flexible endoscopy probe for optical coherence tomography based on stepwise transitional core fiber

      Ultra-thin and flexible endoscopy probe for optical coherence tomography based on stepwise transitional core fiber

      We present an ultra-thin fiber-body endoscopy probe for optical coherence tomography (OCT) which is based on a stepwise transitional core (STC) fiber. In a minimalistic design, our probe was made of spliced specialty fibers that could be directly used for beam probing optics without using a lens. In our probe, the OCT light delivered through a single-mode fiber was efficiently expanded to a large mode field of 24 μm diameter for a low beam divergence. The size of our probe was 85 μm in the probe’s diameter while operated in a 160-μm thick protective tubing. Through theoretical and ...

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    17. Integrated Ultrasound, OCT, PA AND/OR Florescence Imaging Endoscope For Diagnosing Cancers In Gastrointestinal, Respiratory, And Urogenital Tracts

      Integrated Ultrasound, OCT, PA AND/OR Florescence Imaging Endoscope For Diagnosing Cancers In Gastrointestinal, Respiratory, And Urogenital Tracts

      A multimodality imaging system including ultrasound, optical coherence tomography (OCT), photoacoustic (PA) imaging, florescence imaging and endoscopic catheter for imaging inside the gastrointestinal tract with real-time automatic image co-registration capability, including: an ultrasound subsystem for imaging; an optical coherence tomography (OCT) subsystem for imaging, a PA microscopy or tomography subsystem for imaging and a florescence imaging subsystem for imaging. An invasive interventional imaging device is included with an instrumentality to take a tissue biopsy from a location visible on the ultrasound subsystem for imaging, on the optical coherence tomography (OCT) subsystem for imaging, photoacoustic (PA) subsystem for imaging and florescence ...

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    18. Advanced Imaging in Barrett's Esophagus

      Advanced Imaging in Barrett's Esophagus

      BE is estimated to be present in up to 5.6% of the US population and is the precursor lesion for esophageal adenocarcinoma, which has a poor 5-year survival rate of 17%.1,2 Surveillance endoscopy is now the primary management approach for BE, with 4-quadrant biopsies being obtained every 1 to 2 cm at designated intervals in an attempt to identify dysplasia and early neoplasia. The goal of this approach is to treat patients with identified dysplastic or neoplastic lesions with endoscopic eradication therapies in lieu of surgery or chemoradiation, which is used for patients presenting with more advanced ...

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    19. Laser tissue coagulation and concurrent optical coherence tomography through a double-clad fiber coupler

      Laser tissue coagulation and concurrent optical coherence tomography through a double-clad fiber coupler

      Double-clad fiber (DCF) is herein used in conjunction with a double-clad fiber coupler (DCFC) to enable simultaneous and co-registered optical coherence tomography (OCT) and laser tissue coagulation. The DCF allows a single channel fiber-optic probe to be shared: i.e. the core propagating the OCT signal while the inner cladding delivers the coagulation laser light. We herein present a novel DCFC designed and built to combine both signals within a DCF (>90% of single-mode transmission; >65% multimode coupling). Potential OCT imaging degradation mechanisms are also investigated and solutions to mitigate them are presented. The combined DCFC-based system was used to ...

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    20. Integrated OCT-US catheter for detection of cancer in gastrointestinal tract

      Integrated OCT-US catheter for detection of cancer in gastrointestinal tract

      Gastrointestinal tract cancer, the most common type of cancer, has a very low survival rate, especially for pancreatic cancer (five year survival rate of 5%) and bile duct cancer (five year survival rate of 12%). Here, we propose to use an integrated OCT-US catheter for cancer detection. OCT is targeted to acquire detailed information, such as dysplasia and neoplasia, for early detection of tumors. US is used for staging cancers according to the size of the primary tumor and whether or not it has invaded lymph nodes and other parts of the body. Considering the lumen size of the GI ...

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    21. Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components

      Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components

      Polarization Sensitive Optical Coherence Tomography (PSOCT) is a functional extension of Optical Coherence Tomography (OCT) that is sensitive to well-structured, birefringent tissue such as scars, smooth muscle and cartilage. In this work, we present a novel completely fiber based swept source PSOCT system using a fiber-optic rotary pullback catheter. This PSOCT implementation uses only passive optical components and requires no calibration while adding minimal additional cost to a standard structural OCT imaging system. Due to its complete fiber construction, the system can be made compact and robust, while the fiber-optic catheter allows access to most endoscopic imaging sites. The 1 ...

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    22. Feature Of The Week 03/08/2015: Endoscopic Optical Coherence Angiography Enables Three Dimensional Visualization of Subsurface Microvasculature

      Feature Of The Week 03/08/2015: Endoscopic Optical Coherence Angiography Enables Three Dimensional Visualization of Subsurface Microvasculature

      Endoscopic imaging technologies such as confocal laser endomicroscopy (CLE) and narrowband imaging (NBI) have been used to investigate vascular changes as hallmarks of early cancer in the GI tract. However, the limited frame rate and field of view make CLE imaging sensitive to motion artifacts, whereas NBI has limited resolution and visualizes only the surface vascular pattern. Endoscopic optical coherence tomography (OCT) enables high speed volumetric imaging of subsurface features at near-microscopic resolution, and can image microvasculature without exogenous contrast agents such as fluorescein, which obliterates the image in areas of bleeding, or after biopsies and resections. OCT has been ...

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    23. Ultrahigh speed en face OCT capsule for endoscopic imaging

      Ultrahigh speed en face OCT capsule for endoscopic imaging

      Depth resolved and en face OCT visualization in vivo may have important clinical applications in endoscopy. We demonstrate a high speed, two-dimensional (2D) distal scanning capsule with a micromotor for fast rotary scanning and a pneumatic actuator for precision longitudinal scanning. Longitudinal position measurement and image registration were performed by optical tracking of the pneumatic scanner. The 2D scanning device enables high resolution imaging over a small field of view and is suitable for OCT as well as other scanning microscopies. Large field of view imaging for screening or surveillance applications can also be achieved by proximally pulling back or ...

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    24. Postdoctoral Position for the Development of Advanced Optical Technologies in Gastrointestinal Diseases : Erlangen, Germany

      Postdoctoral Position for the Development of Advanced Optical Technologies in Gastrointestinal Diseases : Erlangen, Germany

      As part of the Erlangen Graduate School in Advanced Optical Technologies ( SAOT ) granted by the German Excellence Initiative for Cutting-Edge Research at Institutions of Higher Education, the research group of SAOT Juniorprofessor Maximilian Waldner invites applications for a Postdoc Position Research focus of the Lab/Research projects: The research group focuses on the implementation of new optical technologies for the diagnosis and treatment of gastrointestinal diseases. Current projects evaluate the potential of multiphoton microscopy, optical coherence tomography, hyper-spectral imaging techniques, Raman spectroscopy etc. in preclinical models of inflammatory diseases and cancer of the gastrointestinal tract. Prerequisites for the position are ...

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