Gastroenterology -Optical Coherence Tomography News

Articles in category: Gastroenterology

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1. Endoscopic Optical Coherence Tomography (OCT): Advances in Gastrointestinal Imaging
  
  Explore Hindawi Publishing Corporation Mar 1 2014 Gastroenterology
  
  In the rapidly evolving field of endoscopic gastrointestinal imaging, Optical Coherence Tomography (OCT) has found many diverse applications. We present the current status of OCT and its practical applications in imaging normal and abnormal mucosa in the esophagus, stomach, small and large intestines, and biliary and pancreatic ducts. We highlight technical aspects and principles of imaging, assess published data, and suggest future directions for OCT-guided evaluation and therapy.
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  Mentions: University of Florida St. Jude Medical
2. Recent Advances in Molecular Imaging of Premalignant Gastrointestinal Lesions and Future Application for Early Detection of Barrett Esophagus
  
  Explore CE :: Clinical Endoscopy Feb 28 2014 Gastroenterology
  
  Recent advances in optical molecular imaging allow identification of morphologic and biochemical changes in tissues associated with gastrointestinal (GI) premalignant lesions earlier and in real-time. This focused review series introduces high-resolution imaging modalities that are being evaluated preclinically and clinically for the detection of early GI cancers, especially Barrett esophagus and esophageal adenocarcinoma. Although narrow band imaging, autofluorescence imaging, and chromoendoscopy are currently applied for this purpose in the clinic, further adoptions of probe-based confocal laser endomicroscopy, high-resolution microendoscopy, optical coherence tomography, and metabolomic imaging, as well as imaging mass spectrometry, will lead to detection at the earliest and will ...
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3. Controversial Data Show RFA Beneficial for LGD in Barrett's, but Accurate Diagnosis Is Key
  
  Explore Gastroenterology & Endoscopy News Feb 24 2014 Gastroenterology , Oncology
  
  Radiofrequency ablation (RFA) in Barrett’s esophagus (BE) patients with low-grade dysplasia (LGD) provides significant protection against progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma, according to the findings of a multicenter, randomized trial presented at the 2013 Digestive Disease Week (DDW) meeting. In fact, the benefit of RFA relative to surveillance alone was so great, that the trial’s safety monitoring committee recommended terminating the trial after an interim analysis. The demonstration that RFA can reduce the risk for progression in patients with LGD has immediate relevance to clinical practice, said the senior author of the study, Jacques J ...
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  Mentions: Boston Scientific University of North Carolina Olympus
4. The Medical College of Wisconsin Receives a NIH Grant for Studying Inhibition of Reflex-Induced Esophageal Adenocarcinoma by Proanthocyanidins
  
  Explore Optical Coherence Tomography News Feb 18 2014 Gastroenterology , Funding
  
  The Medical College of Wisconsin Received a 2014 NIH Grrant for $285,728 for Studying Inhibition of Reflex-Induced Esophageal Adenocarcinoma by Proanthocyanidins. The principal investigator is Laura Kresty. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. Esophageal adenocarcinoma (EAC) rates have increased 500% over the last three decades resulting in EAC being identified as the fastest increasing of all cancer types in the US. Esophageal cancer is an extremely deadly malignancy with 5-year survival rates consistently under 20%. The precise reasons for increasing rates of EAC are an active area of ...
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  Mentions: University of Wisconsin National Institutes of Health
5. Advanced Imaging Technologies for the Detection of Dysplasia and Early Cancer in Barrett Esophagus
  
  Explore KoreaMed Synapse Feb 18 2014 Gastroenterology
  
  Abstract Advanced esophageal adenocarcinomas arising from Barrett esophagus (BE) are tumors with an increasing incidence and poor prognosis. The aim of endoscopic surveillance of BE is to detect dysplasia, particularly high-grade dysplasia and intramucosal cancers that can subsequently be treated endoscopically before progression to invasive cancer with lymph node metastases. Current surveillance practice standards require the collection of random 4-quadrant biopsy specimens over every 1 to 2 cm of BE (Seattle protocol) to detect dysplasia with the assistance of white light endoscopy, in addition to performing targeted biopsies of recognizable lesions. This approach is labor-intensive but should currently be considered ...
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  Mentions: University of Toronto
6. Characterization of eosinophilic esophagitis murine models using optical coherence tomography
  
  Explore opticsinfobase.org Feb 2 2014 Gastroenterology
  
  Pre-clinical studies using murine models are critical for understanding the pathophysiological mechanisms underlying immune-mediated disorders such as Eosinophilic esophagitis (EoE). In this study, an optical coherence tomography (OCT) system capable of providing three-dimensional images with axial and transverse resolutions of 5 µm and 10 µm, respectively, was utilized to obtain esophageal images from a murine model of EoE-like disease ex vivo . Structural changes in the esophagus of wild-type ( Tslpr +/+ ) and mutant ( Tslpr −/− ) mice with EoE-like disease were quantitatively evaluated and food impaction sites in the esophagus of diseased mice were monitored using OCT. Here, the capability of OCT as a ...
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  Mentions: Lehigh University University of Pennsylvania Chao Zhou
7. Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study
  
  Explore Gastrointestinal Endoscopy Jan 26 2014 Gastroenterology
  
  Background Biopsy surveillance protocols for the assessment of Barrett's esophagus can be subject to sampling errors, resulting in diagnostic uncertainty. Optical coherence tomography is a cross-sectional imaging technique that can be used to conduct volumetric laser endomicroscopy (VLE) of the entire distal esophagus. We have developed a biopsy guidance platform that places endoscopically visible marks at VLE-determined biopsy sites. Objective The objective of this study was to demonstrate in human participants the safety and feasibility of VLE-guided biopsy in vivo. Design A pilot feasibility study. Setting Massachusetts General Hospital. Patients A total of 22 participants were enrolled from January ...
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  Mentions: Guillermo J. Tearney Brett E. Bouma Massachusetts General Hospital
8. Evaluation of ultrasound and glucose synergy effect on the optical clearing and light penetration for human colon tissue using SD-OCT
  
  Explore Wiley Online Library Jan 25 2014 Gastroenterology
  
  Topical application optical clearing agents (OCAs) can effectively enhance the tissue optical clearing on the human colon tissue, which has been demonstrated in our previous studies. Nevertheless, the strong light scattering still limits the diffusion rate of OCAs and penetration depth of light into the tissue. In this study, in order to further increase the diffusion of the OCA of glucose into tissue, we employ a method to improve the glucose permeability and light penetration with ultrasound (sonophoretic delivery, SP) and glucose (G) synergy on human normal and cancerous colon tissues in vitro, which was measured and quantified with spectral-domain ...
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  Mentions: Peking University Chuanqing Zhou Shanghai Jiao Tong University
9. Deep-Tissue Dysplasia Detection with Real-Time Subcellular Analysis
  
  Explore BioOptics World Jan 22 2014 Gastroenterology , Oncology
  
  Angle-resolved low coherence interferometry (a/LCI) directly measures diagnostically relevant sub-cellular features in epithelial tissues up to 500 μm below the surface. Unlike optical coherence tomography (OCT), which requires image interpretation, a/LCI performs analysis of tissue and delivers to the physician direct confirmation of precancerous disease. Because it offers the greatest opportunity for successful intervention and therapy, a key weapon in the fight against cancer is early detection. If disease can be found in the precancerous stage, before abnormal cells have had the chance to spread throughout the body, the efficacy of treatment can be quite high. The clinical ...
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  Mentions: Adam Wax FDA Oncoscope
10. Endoscopic mucosal resection of Barrett’s esophagus detects high prevalence of subsquamous intestinal metaplasia
  
  Explore World J. Gastroenterology Dec 21 2013 Gastroenterology
  
  AIM: To report the prevalence of Subsquamous intestinal metaplasia (SSIM) in patients undergoing endoscopic mucosal resection (EMR) for staging of Barrett’s esophagus (BE). METHODS: Thirty-three patients with BE associated neoplasia underwent EMR at our institution between September 2009 and September 2011; 22 of these patients met study inclusion criteria. EMR was targeted at focal abnormalities within the BE segment. EMR was performed in standardized fashion using a cap-assisted band ligation technique, and resection specimens were assessed for the presence of SSIM. Demographic and clinical data were analyzed to determine predictors of SSIM. RESULTS: SSIM was detected in 59% of ...
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11. Endoscopic tools for the diagnosis and evaluation of celiac diseas
  
  Explore World J. Gastroenterology Dec 20 2013 Gastroenterology
  
  Celiac disease (CD) is an autoimmune disease of the small bowel induced by ingestion of wheat, rye and barley. Current guidelines indicate histological analysis on at least four duodenal biopsies as the only way to diagnose CD. These indications are based on the conception of the inability of standard endoscopy to make diagnosis of CD and/or to drive biopsy sampling. Over the last years, technology development of endoscopic devices has greatly ameliorated the accuracy of macroscopic evaluation of duodenal villous pattern, increasing the diagnostic power of endoscopy of CD. The aim of this paper is to review the new ...
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12. Covidien Announces Definitive Agreement to Acquire Given Imaging for $860M
  
  Explore Optical Coherence Tomography News Dec 9 2013 Gastroenterology , Acquisition
  
  Covidien Announces Definitive Agreement to Acquire Given Imaging Advances Covidien strategy to more comprehensively address key specialties and procedures globally Adds Given Imaging’s broad suite of minimally invasive gastrointestinal diagnostic and monitoring solutions Accelerates development of world-class gastrointestinal portfolio focused on serving patient from diagnosis to treatment Accretive to earnings per share beginning in fiscal 2015 Covidien plc (NYSE: COV) and Given Imaging Ltd . (Nasdaq: GIVN) today announced a definitive agreement under which Covidien will acquire all of the outstanding shares of Given Imaging for $30.00 per share in cash, for a total of approximately $860 million, net ...
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13. Diagnostic Endoscopy (Textbook)
  
  Explore CRC Press Online Nov 29 2013 Gastroenterology , Textbooks
  
  Combining a professional development course on diagnostic endoscopy from SPIE (the international society advancing light-based research) and the authors’ graduate course on biomedical optics, this work is written for researchers in medical optics and biomedical engineering as well as graduate medical optics students. It uses extensive examples/case studies to familiarize readers with the basics of endoscopic optics, the pros and cons of white light endoscopy and fluorescence endoscopy for diagnostic applications, and various microscopic endoscopy imaging modalities. It covers basic optics, details of design and biomedical uses, as well as microscopic endoscopy, and endoscopic spectroscopy.
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  Mentions: Johns Hopkins University Victor X. D. Yang Beau A. Standish
14. Imaging pancreatobiliary ductal system with optical coherence tomography: A review
  
  Explore World J. Gastroenterology Nov 21 2013 Gastroenterology
  
  An accurate, noninvasive and cost-effective method of in situ tissue evaluation during endoscopy would be highly advantageous for the detection of dysplasia or early cancer and for identifying different disease stages. Optical coherence tomography (OCT) is a noninvasive, high-resolution (1-10 μm) emerging optical imaging method with potential for identifying microscopic subsurface features in the pancreatic and biliary ductal system. Tissue microstructure of pancreaticobiliary ductal system has been successfully imaged by inserting an OCT probe through a standard endoscope operative channel. High-resolution OCT images and the technique’s endoscopic compatibility have allowed for the microstructural diagnostic of the pancreatobiliary diseases. In ...
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  Mentions: Ontario Cancer Institute University of Toronto Victor X. D. Yang
15. British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus
  
  Explore Gut - BMJ Journals Oct 29 2013 Gastroenterology
  
  These guidelines provide a practical and evidence-based resource for the management of patients with Barrett's oesophagus and related early neoplasia. The Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument was followed to provide a methodological strategy for the guideline development. A systematic review of the literature was performed for English language articles published up until December 2012 in order to address controversial issues in Barrett's oesophagus including definition, screening and diagnosis, surveillance, pathological grading for dysplasia, management of dysplasia, and early cancer including training requirements. The rigour and quality of the studies was evaluated using the ...
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  Mentions: University of Manchester University of Cambridge University of Southampton
16. Feature Of The Week 10/27/13: University of St. Andrews Reports on Multi-Modal OCT and Raman Discrimination of Colon Cancer
  
  Explore Optical Coherence Tomography News Oct 27 2013 Gastroenterology
  
  Raman spectroscopy and Optical Coherence Tomography (OCT) are two optical tools that have shown potential to be used for discriminating between normal and abnormal tissue types. Although both of these non-invasive techniques are capable of discriminating between normal and tumour tissues, in many cases, they are unable individually to provide both the high specificity and high sensitivity required for disease diagnosis. Raman spectroscopy and OCT provides complementary information. While Raman spectroscopy provides information about chemical composition of tissues, OCT provides morphological information of tissues. So combining this complementary information might be able to provide higher diagnostic accuracy that is clinically ...
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  Mentions: Praveen Cheriyan Ashok University of St. Andrews Bavishna B. Praveen
17. Image-based noninvasive evaluation of colorectal mucosal injury in sheep after topical application of microbicides
  
  Explore LWW Online Oct 24 2013 Gastroenterology
  
  Background: Successful development of topical rectal microbicides requires preclinical evaluation in suitable large animal models. Our previous studies have demonstrated the benefits of high-resolution optical coherence tomography (OCT) to visualize subclinical microbicide toxicity in the sheep vagina. In the current study, we evaluated the potential application of colonoscopy and OCT to visualize and quantify the effects of topical products on sheep colorectal tissue, as assessed by advanced imaging techniques. Methods: Yearling virginal female sheep were treated rectally with a single 8-mL dose of 0.2% benzalkonium chloride (BZK) solution or phosphate-buffered saline control. Imaging was performed before and 30 minutes ...
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  Mentions: Massoud Motamedi University of Texas Medical Branch
18. Current technology not enough to prevent esophageal adenocarcinoma
  
  Explore Healio.com Oct 21 2013 Gastroenterology
  
  A “disruptive technology” is needed to make significant headway in preventing esophageal adenocarcinoma, a speaker said here. See Also Gatorade/Miralax colonoscopy prep effective, not improved by ... Probiotic did not prevent diarrhea among patients taking ... PPI use may not be linked with loss of bone mineral density ... “What we’re doing now, there’s a very good chance it’s not helping out patients much,” Nicholas J. Shaheen, MD, MPH, said while delivering the Emily Couric Memorial Lecture entitled “Can We Prevent Cancer in Barrett’s Esophagus ?” during the American College of Gastroenterology Annual Scientific Meeting . “You could be looking ...
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  Mentions: Oncoscope Nicholas J. Shaheen
19. MEMS Electrostatic Double T-Shaped Spring Mechanism for Circumferential Scanning
  
  Explore IEEE Xplore Sep 30 2013 Gastroenterology , Probes
  
  A novel microelectromechanical systems (MEMS)-based microscanner is developed with the ultimate goal of integrating it into an endoscopic probe for use in clinical investigations. Microassembly technology is utilized to construct this device, which consists of an electrostatic-based microactuator and a pyramidal polygonal microreflector. A two-stage double T-shaped spring beam system is introduced to the actuator for displacement amplification as well as for motion transfer from the translational movement of the in-plane comb drives to the rotation of the central ring-shaped holder. In the meantime, an eight-slanted-facet-highly-reflective pyramidal polygonal microreflector is developed using high-precision diamond turning and soft lithography technologies ...
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  Mentions: National University of Singapore Guangya Zhou
20. Multi-Modality Endoscopic Imaging for the Detection of Colorectal Cancer (Thesis)
  
  Explore arizona.openrepository.com Sep 24 2013 Gastroenterology , Oncology , Student Theses
  
  Optical coherence tomography (OCT) is an imaging method that is considered the optical analog to ultrasound, using the technique of optical interferometry to construct two-dimensional depth-resolved images of tissue microstructure. With a resolution on the order of 10 μm and a penetration depth of 1-2 mm in highly scattering tissue, fiber optics-coupled OCT is an ideal modality for the inspection of the mouse colon with its miniaturization capabilities. In the present study, the complementary modalities laser-induced fluorescence (LIF), which offers information on the biochemical makeup of the tissue, and surface magnifying chromoendoscopy, which offers high contrast surface visualization, are combined ...
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  Mentions: University of Arizona
21. Enhanced imaging in the GI tract: spectroscopy and optical coherence tomography
  
  Explore Gastrointestinal Endoscopy Sep 20 2013 Gastroenterology
  
  The American Society for Gastrointestinal Endoscopy (ASGE) Technology Committee provides reviews of new or emerging endoscopic technologies that have the potential to have an impact on the practice of GI endoscopy. Evidence-based methodology is used, using a MEDLINE literature search to identify pertinent preclinical and clinical studies on the topic, and a MAUDE (U.S. Food and Drug Administration Center for Devices and Radiological Health) database search to identify the reported adverse events of a given technology. Both are supplemented by accessing the “related articles” feature of PubMed and by scrutinizing pertinent references cited by the identified studies. Controlled clinical ...
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22. Probe alignment and design issues of microelectromechanical system based optical coherence tomography endoscopic imaging
  
  Explore opticsinfobase.org Sep 6 2013 Gastroenterology , Probes
  
  Endoscopic optical coherence tomography (OCT) imaging has been demonstrated using microelectromechanical system (MEMS) technology by several research groups. The focus of this work is to study how the OCT imaging performance is affected by the radius of curvature of MEMS mirrors as well as the optical alignment accuracy inside small imaging probes. The goal of this study is to provide guidance for assembly tolerance and design optimization of OCT endoscopic probes. Gaussian beam propagation is used for theoretical analysis which is confirmed by optical simulation and verified experimentally with a time-domain OCT system as well. It has been found that ...
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  Mentions: University of Florida Huikai K. Xie Jingjing Sun
23. Correction of image distortions in endoscopic optical coherence tomography based on two-axis scanning MEMS mirrors
  
  Explore opticsinfobase.org Sep 6 2013 Gastroenterology , Probes
  
  A two-axis scanning microelectromechanical (MEMS) mirror enables an optical coherence tomography (OCT) system to perform three-dimensional endoscopic imaging due to its fast scan speed and small size. However, the radial scan from the MEMS mirror causes various distortions in OCT images, namely spherical, fan-shaped and keystone distortions. In this paper, a new method is proposed to correct all of three distortions presented in OCT systems based on two-axis MEMS scanning mirrors. The spherical distortion is corrected first by directly manipulating the original spectral interferograms in the phase domain, followed by Fourier transform and three-dimensional geometrical transformation for correcting the other ...
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  Mentions: University of Florida Huikai K. Xie WiO Technology Limited
24. NvisionVLE scans esophageal tissues in real time
  
  Explore optics.org Aug 20 2013 Gastroenterology , Funding
  
  The potential value of optical coherence tomography (OCT) in applications beyond its established presence in ophthalmology has been clear to developers for some time, with significant strides being made in both imaging depth and scan rate. One attractive example is its use in imaging the soft tissues of the gastrointestinal tract and examining pre-cancerous conditions such as Barrett's esophagus, where conventional white light endoscopy suffers from a number of drawbacks. Launched commercially earlier in 2013, the NvisionVLE system from NinePoint Medical allows clinicians to evaluate the esophageal tissue microstructure with OCT during a standard endoscopy procedure. "NinePoint Medical was ...
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  Mentions: Massachusetts General Hospital NinePoint Medical Charles Carignan
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