Gastroenterology -Optical Coherence Tomography News

Articles in category: Gastroenterology

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1. NinePoint Medical Announces FDA Clearance of an Artificial Intelligence Software Upgrade for the NvisionVLE Imaging System
  
  Explore Optical Coherence Tomography News Nov 5 2018 Gastroenterology , Other Business News
  
  NinePoint Medical, Inc., a transformative medical device company pioneering the use of a real-time imaging platform for gastrointestinal applications, announced today that it has received U.S. Food and Drug Administration (FDA) clearance to market its Intelligent Real-time Image Segmentation™ (IRIS) software upgrade for its flagship product, the NvisionVLE Imaging System. IRIS, an artificial intelligence-based platform for image feature segmentation, is the first tool of its kind approved for use in imaging of esophageal tissue. The NvisionVLE Imaging System allows physicians to perform a Volumetric Laser Endomicroscopy (VLE) procedure that produces real-time, high-resolution cross-sectional images. This system enables gastroenterologists to ...
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  Mentions: FDA NinePoint Medical Eman Namati
2. Super‐achromatic Optical Coherence Tomography Capsule for Ultrahigh‐resolution Imaging of Esophagus
  
  Explore Wiley Online Library Oct 10 2018 Gastroenterology , Probes
  
  Endoscopic optical coherence tomography (OCT) is a noninvasive technology allowing for imaging of tissue microanatomies of luminal organs in real time. Conventional endoscopic OCT operates at 1,300 nm wavelength region with a sub‐optimal axial resolution limited to 8‐20 μm. In this paper we present the first ultrahigh‐resolution tethered OCT capsule operating at 800 nm and offering about 3‐4 fold improvement of axial resolution (plus enhanced imaging contrast). The capsule uses diffractive optics to manage chromatic aberration over a full ~200 nm spectral bandwidth centering around 830 nm, enabling to achieve super‐achromaticity and an axial ...
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  Mentions: Johns Hopkins University Xingde Li
3. Feature Of The Week 10/08/2018: Clinical Utility of Ultrahigh-Speed Endoscopic Optical Coherence Tomography in Gastroenterology
  
  Explore Optical Coherence Tomography News Oct 7 2018 Gastroenterology
  
  Barrett’s esophagus (BE) surveillance is limited by biopsy sampling error. Optical coherence tomography (OCT) enables microscopic resolution, high speed, volumetric imaging and is commercially available as volumetric laser endomicroscopy (VLE, NinePoint Medical). Studies investigated cross-sectional OCT dysplasia features, including a diagnostic algorithm (VLE-DA), however, many VLE studies used ex vivo specimens due to challenges in registering biopsy with OCT. We previously demonstrated ultrahigh-speed endoscopic OCT >10x faster than commercial instruments, enabling depth-resolved en face and cross-sectional imaging. This study investigated volumetric en face and cross-sectional OCT for identifying neoplasia. 74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
4. Advanced Endoluminal Technologies for Barrett's Esophagus: Focus on Optical Coherence Tomography and Confocal Laser Endomicroscopy
  
  Explore Thoracic Surgery Clinics Oct 1 2018 Gastroenterology
  
  High-definition flexible endoscopes allow detailed evaluation of esophageal mucosa and indemnification of the squamocolumnan junction, as well as islands, tongues, or a circumferential extensions of the columnar mucosa into the esophagus.
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5. Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography
  
  Explore thieme-connect.de Sep 30 2018 Gastroenterology
  
  Background This study aimed to evaluate the use of ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography (OCT) with micromotor catheters for the in vivo assessment of Barrett’s esophagus and dysplasia. Methods 74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology (49 nondysplastic Barrett’s esophagus [NDBE], 25 neoplasia) were obtained from 14 patients with Barrett’s esophagus and a history of dysplasia and 30 with NDBE. The associations between irregular mucosal patterns on en face OCT, absence of mucosal layering, surface signal > subsurface, and > 5 atypical glands on cross-sectional OCT vs. histology and treatment history were ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
6. Swept-source optical coherence tomography microsystem with an integrated Mirau interferometer and electrothermal micro-scanner
  
  Explore etoponline.org Sep 28 2018 Gastroenterology , Probes
  
  In the rapid evolution of gastrointestinal endomicroscopy, optical coherence tomography (OCT) has found many diverse applications. Until recently, the micro-opto–electro-mechanical systems (MOEMS) technology has been playing a key role in shaping the miniaturization of these components. We report here, to the best of our knowledge, a novel endoscopic microsystem. It is based on a spectrally tuned MOEMS Mirau micro-interferometer integrated with micro-electro-mechanical systems (MEMS) electro-thermal micro-scanner, operating in the regime of swept-source (SS) OCT imaging. This Letter validates our initial proof-of-concept toward the development of such MOEMS probe and the presentation of experimental performances of the resulting SS-OCT microsystem. .
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  Mentions: University of Florida Huikai K. Xie
7. Full-field Optical Coherence Tomography: A New Imaging Modality for rapid on-site Evaluation of resected Polyps during Colonoscopy
  
  Explore Gastroenterology Sep 16 2018 Gastroenterology
  
  No abstract provided.
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  Mentions: LLTech Eugénie Dalimier
8. Predict Recurrence of Barrett's Esophagus After Complete Eradication of Intestinal Metaplasia
  
  Explore Home - ClinicalTrials.gov Sep 13 2018 Gastroenterology , Clinical Trials
  
  Patients with Barrett's Esophagus (BE) undergoing endoscopic therapy through our Barrett's Esophagus Unit will be approached for study enrollment. Patients with no endoscopic evidence of BE will be considered for the study. Surveillance biopsies will be obtained per standard clinical protocol and reviewed to confirm absence of intestinal metaplasia. Patients who have achieved complete eradication of intestinal metaplasia (CRIM) will be enrolled in the study and will undergo the Nvision® Imaging System (VLE). Patients enrolled in the study will undergo clinical follow-up consisting of surveillance endoscopy every 3 months for 1 year. Surveillance endoscopy intervals may be prolonged ...
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  Mentions: NinePoint Medical
9. Assessment and Diagnosis of Human Ovarian and Colorectal Cancer using Optical and Photoacoustic Imaging (Thesis)
  
  Explore Washington University Open Scholarship Sep 11 2018 Gastroenterology , Gynecology , Student Theses
  
  Optical imaging modalities have the advantage of high resolution, label free, rapid, low cost imaging for both in vivo and ex vivo diagnosis of biological tissues. Optical scattering, which is the main contrast of optical coherence tomography (OCT), is related to elastic scattering components, mainly stromal collagen. Tissue elasticity has recently emerged as an important diagnostic parameter associated with tumor development and progression and is also related to the distribution of structural components such as tissue collagen. We have used an optical coherence tomography elastography (OCTE) system for characterizing the differences in the micro-mechanical properties of benign and malignant human ...
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  Mentions: Washington University in St. Louis
10. Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study
  
  Explore OSA | OSA Publishing Aug 20 2018 Gastroenterology
  
  Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate between healthy tissue, fibrotic tissue, and residual cancer with a sensitivity and specificity of 79% and 67%, respectively. Hence, OCT has the potential to add to the assessment of a ...
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  Mentions: Johannes F. de Boer Academic Medical Center at the University of Amsterdam VU University Amsterdam
11. Nano-optic endoscope for high-resolution optical coherence tomography in vivo
  
  Explore Nature Publishing Group Jul 30 2018 Gastroenterology , Probes
  
  Acquisition of high-resolution images from within internal organs using endoscopic optical imaging has numerous clinical applications. However, difficulties associated with optical aberrations and the trade-off between transverse resolution and depth of focus significantly limit the scope of applications. Here, we integrate a metalens, with the ability to modify the phase of incident light at subwavelength level, into the design of an endoscopic optical coherence tomography catheter (termed nano-optic endoscope) to achieve near diffraction-limited imaging through negating non-chromatic aberrations. Remarkably, the tailored chromatic dispersion of the metalens in the context of spectral interferometry is utilized to maintain high-resolution imaging beyond the ...
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  Mentions: Massachusetts General Hospital Harvard University Melissa J. Suter
12. NinePoint Medical Appoints Eman Namati, Ph.D., to Chief Executive Officer
  
  Explore Optical Coherence Tomography News Jun 28 2018 Gastroenterology , Other Business News
  
  NinePoint Medical, Inc, a transformative medical device company pioneering the use of Optical Coherence Tomography (OCT) for gastrointestinal applications, is pleased to announce the appointment of Eman Namati, Ph.D., to President and Chief Executive Officer. Dr. Namati succeeds Christopher von Jako, Ph.D., who will continue to serve on the Board of Directors as an independent member. Dr. Namati will assume day-to-day leadership at NinePoint Medical while working in collaboration with Merit Medical Systems Inc. (NASDAQ:MMSI), who now manages the sales distribution and customer service for the NvisionVLE®Imaging System. "With the recent strategic partnership NinePoint entered into ...
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  Mentions: Guillermo J. Tearney Brett E. Bouma Massachusetts General Hospital
13. Optical Coherence Tomography for Barrett Esophagus
  
  Explore gastroenterologyandhepatology.net Jun 26 2018 Gastroenterology
  
  G&H Can you provide a brief overview of optical coherence tomography? VK Optical coherence tomography (OCT) is an advanced imaging technology that was developed in the 1990s. Its application in the endoscopic realm began in the late 1990s. Approximately 5 years ago, a second-generation, advanced OCT technology known as volumetric laser endomicroscopy (VLE; NvisionVLE Imaging System, NinePoint Medical) became available in the US market. Since then, VLE has been the main commercially available OCT-platform product approved by the US Food and Drug Administration for the purpose of advanced endoscopic imaging. The mechanism by which OCT technology works is by ...
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  Mentions: University of Rochester NinePoint Medical
14. Innovative Endoscopies to Be Clinically Used in the Near Future
  
  Explore Home - Springer Jun 23 2018 Gastroenterology , Probes
  
  In contrast to traditional single-lens endoscopies, recently introduced full-spectrum endoscopy (FUSE) scopes include multiple lenses providing a much wider field of view. In many studies, FUSE was shown to be feasible, effective, and safe, and FUSE colonoscopy yielded higher polyp (PDR), adenoma (ADR), and diverticular (DDR) detection rates than did traditional colonoscopy, without therapeutic failure or complications. Moreover, using FUSE gastroscopy, the prevalence of duodenal peri-ampullary diverticula (DPAD) in the general population could be analyzed without using ERCP. In the future, the next generation of modified FUSE system is expected to be useful in direct peroral cholangioscopy and in simultaneous ...
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15. Gastrointestinal Endoscopy Editorial Board top 10 topics: advances in GI endoscopy in 2017
  
  Explore Gastrointestinal Endoscopy May 24 2018 Gastroenterology
  
  Much effort during the past 2 decades has focused on developing novel imaging techniques to enable real-time “optical biopsy” during endoscopy. The ASGE’s Preservation and Incorporation of Valuable Endoscopic Innovations initiative recommends appropriate thresholds for application of novel imaging, particularly narrow-band imaging, when trained endoscopists evaluate BE and small colon polyps.40,41 Although narrow-band imaging has been available in most endoscopy units for many years, its application for management of BE in routine practice is still unclear. In 2017, a retrospective analysis of BE detection before and after the institution of a novel imaging– directed biopsy program did ...
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16. Multimodality endoscopic optical coherence tomography and fluorescence imaging technology for visualization of layered architecture and subsurface microvasculature
  
  Explore OSA | OSA Publishing May 2 2018 Gastroenterology , Probes
  
  Endoscopic imaging technologies, such as endoscopic optical coherence tomography (OCT) and near-infrared fluorescence, have been used to investigate vascular and morphological changes as hallmarks of early cancer in the gastrointestinal tract. Here we developed a high-speed multimodality endoscopic OCT and fluorescence imaging system. Using this system, the architectural morphology and vasculature of the rectum wall were obtained simultaneously from a Sprague Dawley rat in vivo . This multimodality imaging strategy in a single imaging system permits the use of a single imaging probe, thereby improving prognosis by early detection and reducing costs.
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  Mentions: Zhongping Chen UC Irvine Yan Li
17. NinePoint Medical, Inc. Enters Into A Strategic Partnership and Worldwide Distribution with Merit Medical Systems, Inc.
  
  Explore Optical Coherence Tomography News May 1 2018 Gastroenterology , Other Business News , Partnership
  
  NinePoint Medical, Inc., a transformative medical device company pioneering the use of Optical Coherence Tomography (OCT) for gastrointestinal applications, today announced a long-term strategic partnership with Merit Medical Systems, Inc. (NASDAQ: MMSI ). This partnership includes a strategic investment and a worldwide distribution agreement with Merit Medical’s endoscopic division, Merit Medical Endotek® (Endotek), for NinePoint Medical’s NvisionVLE® Imaging System with Real-time Targeting™. This partnership combines the world-class Gastrointestinal (GI) and Pulmonary medical devices from Endotek with the ground-breaking Advanced OCT platform from NinePoint Medical. This OCT platform has, in a short period of time, become a primary imaging device ...
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  Mentions: FDA NinePoint Medical
18. Feasibility of Optical Coherence Tomography (OCT) for Intra-Operative Detection of Blood Flow during Gastric Tube Reconstruction
  
  Explore MDPI Open Access Journals Platform Apr 25 2018 Gastroenterology
  
  In this study; an OCT-based intra-operative imaging method for blood flow detection during esophagectomy with gastric tube reconstruction is investigated. Change in perfusion of the gastric tube tissue can lead to ischemia; with a high morbidity and mortality as a result. Anastomotic leakage (incidence 5–20%) is one of the most severe complications after esophagectomy with gastric tube reconstruction. Optical imaging techniques provide for minimal-invasive and real-time visualization tools that can be used in intraoperative settings. By implementing an optical technique for blood flow detection during surgery; perfusion can be imaged and quantified and; if needed; perfusion can be improved ...
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  Mentions: Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen Daniël M. de Bruin
19. Feasibility of using optical coherence tomography to detect acute radiation-induced esophageal damage in small animal models
  
  Explore SPIE Digital Library Apr 16 2018 Gastroenterology
  
  Lung cancer survival is poor, and radiation therapy patients often suffer serious treatment side effects. The esophagus is particularly sensitive leading to acute radiation-induced esophageal damage (ARIED). We investigated the feasibility of optical coherence tomography (OCT) for minimally invasive imaging of the esophagus with high resolution (10 μm) to detect ARIED in mice. Thirty mice underwent cone-beam computed tomography imaging for initial setup assessment and dose planning followed by a single-dose delivery of 4.0, 10.0, 16.0, and 20.0 Gy on 5.0-mm spots, spaced 10.0 mm apart in the esophagus. They were repeatedly imaged using ...
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  Mentions: Johannes F. de Boer Academic Medical Center at the University of Amsterdam Ton G. van Leeuwen
20. Incremental yield of dysplasia detection in Barrett’s esophagus using volumetric laser endomicroscopy with and without laser marking compared with a standardized random biopsy protocol
  
  Explore Gastrointestinal Endoscopy Mar 20 2018 Gastroenterology
  
  Background and Aims Volumetric laser endomicroscopy (VLE) is a new wide-field advanced imaging technology for Barrett’s esophagus (BE). No data exist on incremental yield of dysplasia detection. Our aim is to report the incremental yield of dysplasia detection in BE using VLE. Methods This is a retrospective study from a prospectively maintained database from 2011 to 2017 comparing the dysplasia yield of 4 different surveillance strategies in an academic BE tertiary care referral center. The groups were (1) random biopsies (RB), (2) Seattle protocol random biopsies (SP), (3) VLE without laser marking (VLE), and (4) VLE with laser marking ...
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  Mentions: NinePoint Medical
21. Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy
  
  Explore SPIE Digital Library Mar 20 2018 Gastroenterology
  
  Tethered capsule endomicroscopy (TCE) is a new method for performing comprehensive microstructural OCT imaging of gastrointestinal (GI) tract in unsedated patients in a well-tolerated and cost-effective manner. These features of TCE bestow it with significant potential to improve the screening, surveillance and management of various upper gastrointestinal diseases. To achieve clinical adoption of this imaging technique, it is important to validate it with co-registered histology, the current diagnostic gold standard. One such method for co-registering OCT images with histology is laser cautery marking, previously demonstrated using a balloon-centering OCT catheter that operates in conjunction with sedated endoscopy. With laser marking ...
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  Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University
22. Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones
  
  Explore OSA | OSA Publishing Mar 18 2018 Gastroenterology
  
  Microwave ablation is a minimally invasive image guided thermal therapy for cancer that can be adapted to endoscope use in the gastrointestinal (GI) tract. Microwave ablation in the GI tract requires precise control over the ablation zone that could be guided by high resolution imaging with quantitative contrast. Optical coherence tomography (OCT) provides ideal imaging resolution and allows for the quantification of tissue scattering properties to characterize ablated tissue. Visible and near-infrared OCT image analysis demonstrated increased scattering coefficients ( μ s ) in ablated versus normal tissues (Vis: 347.8%, NIR: 415.0%) and shows the potential for both wavelength ranges to ...
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  Mentions: University of Wisconsin Melissa C. Skala
23. Automated detection of esophageal dysplasia in in vivo optical coherence tomography images of the human esophagus
  
  Explore SPIE Digital Library Feb 27 2018 Gastroenterology
  
  Catheter-based Optical Coherence Tomography (OCT) devices allow real-time and comprehensive imaging of the human esophagus. Hence, they provide the potential to overcome some of the limitations of endoscopy and biopsy, allowing earlier diagnosis and better prognosis for esophageal adenocarcinoma patients. However, the large number of images produced during every scan makes manual evaluation of the data exceedingly difficult. In this study, we propose a fully automated tissue characterization algorithm, capable of discriminating normal tissue from Barrett’s Esophagus (BE) and dysplasia through entire three-dimensional (3D) data sets, acquired in vivo. The method is based on both the estimation of the ...
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  Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University
24. Full depth measurement of tenofovir transport in rectal mucosa using confocal Raman spectroscopy and optical coherence tomography
  
  Explore Home - Springer Feb 27 2018 Gastroenterology
  
  The prophylactic activity of antiretroviral drugs applied as microbicides against sexually transmitted HIV is dependent upon their concentrations in infectable host cells. Within mucosal sites of infection (e.g., vaginal and rectal mucosa), those cells exist primarily in the stromal layer of the tissue. Traditional pharmacokinetic studies of these drugs have been challenged by poor temporal and spatial specificity. Newer techniques to measure drug concentrations, involving Raman spectroscopy, have been limited by laser penetration depth into tissue. Utilizing confocal Raman spectroscopy (RS) in conjunction with optical coherence tomography (OCT), a new lateral imaging assay enabled concentration distributions to be imaged ...
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  Mentions: Duke University Jason R. Maher
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