1. Articles in category: Gastroenterology

    1-24 of 463 1 2 3 4 ... 18 19 20 »
    1. Micro-Tech Developing a SS-OCT Endoscopic System for Gastroenterology

      Micro-Tech Developing a SS-OCT Endoscopic System for Gastroenterology

      Micro-Tech an medical company in China established in 1999 is developing a SS-OCT endoscopic system. The system was shown at DDW 2015 and was developed by Jiefeng Xi a Principle Engineer at Micro-Tech and former PhD student at Johns Hopkins who graduated in July 2014. For more information click HERE .

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    2. Optical coherence tomography after POEM

      Optical coherence tomography after POEM

      Amy Tyberg, MD, from Weill Cornell Medical College in New York, New York, USA presents this video case “Endoscopic optical coherence tomography as a tool to evaluate successful myotomy after a peroral endoscopic myotomy.” This case describes a 51-year-old woman with achalasia who underwent a per-oral endoscopic myotomy (POEM) with complete resolution of her symptoms post-procedure. A repeat endoscopy with optical coherence tomography (OCT) was performed post-procedure to confirm successful myotomy.  

      OCT is an exciting new technology that allows for two-dimensional, cross-sectional imaging of the esophageal wall in vivo. This technology has been well studied in Barrett’s esophagus  as ...

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    3. Optical coherence tomography and intravascular ultrasound evaluation of cardiac allograft vasculopathy with and without intimal neovascularization

      Optical coherence tomography and intravascular ultrasound evaluation of cardiac allograft vasculopathy with and without intimal neovascularization

      Aims Neovascularization is closely associated with plaque progression in non-heart transplantation subjects; on the other hand, cardiac allograft vasculopathy causes unfavourable outcomes. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) can provide microscopic assessment in vivo . The aim of this study was to investigate the impact of neovascularization on intimal proliferation. Methods and results Both IVUS and OCT were attempted in 45 consecutive patients during annual catheterization after heart transplantation. There were 115 vessels [28 vessels were catheterized within 8 weeks of heart transplantation (baseline)]. IVUS analysis assessed vessel, luminal, and intimal (vessel-lumen) volume using Simpson's method. Qualitative parameters ...

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    4. Emerging optical methods for surveillance of Barrett's oesophagus

      Emerging optical methods for surveillance of Barrett's oesophagus

      The rapid rise in incidence of oesophageal adenocarcinoma has motivated the need for improved methods for surveillance of Barrett's oesophagus. Early neoplasia is flat in morphology and patchy in distribution and is difficult to detect with conventional white light endoscopy (WLE). Light offers numerous advantages for rapidly visualising the oesophagus, and advanced optical methods are being developed for wide-field and cross-sectional imaging to guide tissue biopsy and stage early neoplasia, respectively. We review key features of these promising methods and address their potential to improve detection of Barrett's neoplasia. The clinical performance of key advanced imaging technologies is ...

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    5. New Clinical Data Using the NvisionVLE® Imaging System to be Presented at Digestive Disease Week® 2015

      New Clinical Data Using the NvisionVLE® Imaging System to be Presented at Digestive Disease Week® 2015

      NinePoint Medical, Inc. , an emerging leader in the development of medical devices for advanced imaging, today announced that new clinical data relating to its proprietary NvisionVLE ® Imaging System, will be presented in a series of oral and poster presentations during Digestive Disease Week ® (DDW ® ) 2015. The annual meeting will take place May 16-19th in Washington, DC. The schedule for scientific presentations related to advanced optical coherence tomography (OCT) and the NvisionVLE ® Imaging System at DDW 2015 is provided below. SATURDAY, May 16, 2015 Three posters will be presented on Saturday, May 16 at 9:30am in Hall C of Walter ...

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    6. Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos)

      Safety and feasibility of volumetric laser endomicroscopy in patients with Barrett’s esophagus (with videos)

      Background Volumetric laser endomicroscopy (VLE) produces high-resolution, cross-sectional surface, and subsurface images for detecting neoplasia, targeting biopsies, and guiding real-time treatment. Objective To evaluate the safety and feasibility of the Nvision VLE system. Design Prospective, multicenter study. Setting Tertiary-care medical centers. Patients One hundred patients with suspected Barrett’s esophagus, including 52 patients with prior endotherapy. Interventions The first-generation Nvision VLE Imaging System, a balloon-centered, rotating optical probe provided images of the mucosa and submucosa through a 6-cm segment length and 360° scan of the distal esophagus. Main Outcome Measurements Acquisition of a complete, 6-cm scan from the distal esophagus ...

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    7. Volumetric laser endomicroscopy in Barrett's esophagus: a feasibility study on histological correlation

      Volumetric laser endomicroscopy in Barrett's esophagus: a feasibility study on histological correlation

      Volumetric laser endomicroscopy (VLE) is a novel balloon-based optical coherence tomography (OCT) imaging technique that may improve detection of early neoplasia in Barrett's esophagus (BE). Most OCT studies lack a direct correlation between histology and OCT images. The aim is to investigate the optimal approach for achieving one-to-one correlation of ex-vivo VLE images of endoscopic resection (ER) specimens with histology. BE patients with and without early neoplasia underwent ER after delineating areas with electrocoagulation markers (ECM). After ER, specimens underwent additional ex-vivo marking with several different markers (ink, pin, Gold Probe) followed by ex-vivo VLE scanning. ER specimens were ...

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    8. Feature Of The Week 5/10/2015: Laser Tissue Coagulation and Concurrent Optical Coherence Tomography Through a Double-Clad Fiber Coupler

      Feature Of The Week 5/10/2015: Laser Tissue Coagulation and Concurrent Optical Coherence Tomography Through a Double-Clad Fiber Coupler

      This work is the result of a collaboration between researchers from Professor Caroline Boudoux’s team from Polytechnique Montréal (Canada) and Professor Brett E. Bouma’s team at the Wellman Center for Photomedicine (MGH, Boston). The goal is to assess whether OCT-guided biopsy could benefit from the use of double-clad fiber (DCF). DCF allows a single channel fiber-optic probe to be shared: i.e. the core propagating the OCT signal while the inner cladding delivers the coagulation laser light used for laser marking. DCF is herein used in conjunction with a double-clad fiber coupler (DCFC) to enable simultaneous and ...

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    9. Ultra-thin and flexible endoscopy probe for optical coherence tomography based on stepwise transitional core fiber

      Ultra-thin and flexible endoscopy probe for optical coherence tomography based on stepwise transitional core fiber

      We present an ultra-thin fiber-body endoscopy probe for optical coherence tomography (OCT) which is based on a stepwise transitional core (STC) fiber. In a minimalistic design, our probe was made of spliced specialty fibers that could be directly used for beam probing optics without using a lens. In our probe, the OCT light delivered through a single-mode fiber was efficiently expanded to a large mode field of 24 μm diameter for a low beam divergence. The size of our probe was 85 μm in the probe’s diameter while operated in a 160-μm thick protective tubing. Through theoretical and ...

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    10. Integrated Ultrasound, OCT, PA AND/OR Florescence Imaging Endoscope For Diagnosing Cancers In Gastrointestinal, Respiratory, And Urogenital Tracts

      Integrated Ultrasound, OCT, PA AND/OR Florescence Imaging Endoscope For Diagnosing Cancers In Gastrointestinal, Respiratory, And Urogenital Tracts

      A multimodality imaging system including ultrasound, optical coherence tomography (OCT), photoacoustic (PA) imaging, florescence imaging and endoscopic catheter for imaging inside the gastrointestinal tract with real-time automatic image co-registration capability, including: an ultrasound subsystem for imaging; an optical coherence tomography (OCT) subsystem for imaging, a PA microscopy or tomography subsystem for imaging and a florescence imaging subsystem for imaging. An invasive interventional imaging device is included with an instrumentality to take a tissue biopsy from a location visible on the ultrasound subsystem for imaging, on the optical coherence tomography (OCT) subsystem for imaging, photoacoustic (PA) subsystem for imaging and florescence ...

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    11. Advanced Imaging in Barrett's Esophagus

      Advanced Imaging in Barrett's Esophagus

      BE is estimated to be present in up to 5.6% of the US population and is the precursor lesion for esophageal adenocarcinoma, which has a poor 5-year survival rate of 17%.1,2 Surveillance endoscopy is now the primary management approach for BE, with 4-quadrant biopsies being obtained every 1 to 2 cm at designated intervals in an attempt to identify dysplasia and early neoplasia. The goal of this approach is to treat patients with identified dysplastic or neoplastic lesions with endoscopic eradication therapies in lieu of surgery or chemoradiation, which is used for patients presenting with more advanced ...

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    12. Laser tissue coagulation and concurrent optical coherence tomography through a double-clad fiber coupler

      Laser tissue coagulation and concurrent optical coherence tomography through a double-clad fiber coupler

      Double-clad fiber (DCF) is herein used in conjunction with a double-clad fiber coupler (DCFC) to enable simultaneous and co-registered optical coherence tomography (OCT) and laser tissue coagulation. The DCF allows a single channel fiber-optic probe to be shared: i.e. the core propagating the OCT signal while the inner cladding delivers the coagulation laser light. We herein present a novel DCFC designed and built to combine both signals within a DCF (>90% of single-mode transmission; >65% multimode coupling). Potential OCT imaging degradation mechanisms are also investigated and solutions to mitigate them are presented. The combined DCFC-based system was used to ...

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    13. Integrated OCT-US catheter for detection of cancer in gastrointestinal tract

      Integrated OCT-US catheter for detection of cancer in gastrointestinal tract

      Gastrointestinal tract cancer, the most common type of cancer, has a very low survival rate, especially for pancreatic cancer (five year survival rate of 5%) and bile duct cancer (five year survival rate of 12%). Here, we propose to use an integrated OCT-US catheter for cancer detection. OCT is targeted to acquire detailed information, such as dysplasia and neoplasia, for early detection of tumors. US is used for staging cancers according to the size of the primary tumor and whether or not it has invaded lymph nodes and other parts of the body. Considering the lumen size of the GI ...

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    14. Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components

      Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components

      Polarization Sensitive Optical Coherence Tomography (PSOCT) is a functional extension of Optical Coherence Tomography (OCT) that is sensitive to well-structured, birefringent tissue such as scars, smooth muscle and cartilage. In this work, we present a novel completely fiber based swept source PSOCT system using a fiber-optic rotary pullback catheter. This PSOCT implementation uses only passive optical components and requires no calibration while adding minimal additional cost to a standard structural OCT imaging system. Due to its complete fiber construction, the system can be made compact and robust, while the fiber-optic catheter allows access to most endoscopic imaging sites. The 1 ...

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    15. Feature Of The Week 03/08/2015: Endoscopic Optical Coherence Angiography Enables Three Dimensional Visualization of Subsurface Microvasculature

      Feature Of The Week 03/08/2015: Endoscopic Optical Coherence Angiography Enables Three Dimensional Visualization of Subsurface Microvasculature

      Endoscopic imaging technologies such as confocal laser endomicroscopy (CLE) and narrowband imaging (NBI) have been used to investigate vascular changes as hallmarks of early cancer in the GI tract. However, the limited frame rate and field of view make CLE imaging sensitive to motion artifacts, whereas NBI has limited resolution and visualizes only the surface vascular pattern. Endoscopic optical coherence tomography (OCT) enables high speed volumetric imaging of subsurface features at near-microscopic resolution, and can image microvasculature without exogenous contrast agents such as fluorescein, which obliterates the image in areas of bleeding, or after biopsies and resections. OCT has been ...

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    16. Ultrahigh speed en face OCT capsule for endoscopic imaging

      Ultrahigh speed en face OCT capsule for endoscopic imaging

      Depth resolved and en face OCT visualization in vivo may have important clinical applications in endoscopy. We demonstrate a high speed, two-dimensional (2D) distal scanning capsule with a micromotor for fast rotary scanning and a pneumatic actuator for precision longitudinal scanning. Longitudinal position measurement and image registration were performed by optical tracking of the pneumatic scanner. The 2D scanning device enables high resolution imaging over a small field of view and is suitable for OCT as well as other scanning microscopies. Large field of view imaging for screening or surveillance applications can also be achieved by proximally pulling back or ...

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    17. Postdoctoral Position for the Development of Advanced Optical Technologies in Gastrointestinal Diseases : Erlangen, Germany

      Postdoctoral Position for the Development of Advanced Optical Technologies in Gastrointestinal Diseases : Erlangen, Germany

      As part of the Erlangen Graduate School in Advanced Optical Technologies ( SAOT ) granted by the German Excellence Initiative for Cutting-Edge Research at Institutions of Higher Education, the research group of SAOT Juniorprofessor Maximilian Waldner invites applications for a Postdoc Position Research focus of the Lab/Research projects: The research group focuses on the implementation of new optical technologies for the diagnosis and treatment of gastrointestinal diseases. Current projects evaluate the potential of multiphoton microscopy, optical coherence tomography, hyper-spectral imaging techniques, Raman spectroscopy etc. in preclinical models of inflammatory diseases and cancer of the gastrointestinal tract. Prerequisites for the position are ...

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    18. Emerging Enhanced Imaging Technologies of the Esophagus: Spectroscopy, Confocal Laser Endomicroscopy, and Optical Coherence Tomography

      Emerging Enhanced Imaging Technologies of the Esophagus: Spectroscopy, Confocal Laser Endomicroscopy, and Optical Coherence Tomography

      Introduction Despite advances in diagnoses and therapy, esophageal adenocarcinoma remains a highly lethal neoplasm. Hence, a great interest has been placed in detecting early lesions and in the detection of Barrett’s esophagus (BE). Advanced imaging technologies of the esophagus have then been developed with the aim of improving biopsy sensitivity and detection of pre- and neoplastic cells. The purpose of this manuscript is to review emerging imaging technologies for esophageal pathology, Spectroscopy, Confocal Laser Endomicroscopy (CLE), and Optical Coherence Tomography (OCT). Methods We conducted a PubMed search using the search string: (esophagus OR esophageal OR oesophageal OR oesophagus) AND ...

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    19. Medical College of Wisconsin Receives NIH Grant to study Inhibition of Reflux-Induced Esophageal Adenocarinoma by Proanthocyanidins.

      Medical College of Wisconsin Receives NIH Grant  to study Inhibition of Reflux-Induced Esophageal Adenocarinoma by Proanthocyanidins.

      Medical College of Wisconsin Received a 2015 NIH Grant for $317,475 to study Inhibition of Reflux-Induced Esophageal Adenocarinoma by Proanthocyanidins. The prinipal investigator is Laura Kreesty. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. Esophageal adenocarcinoma (EAC) rates have increased 500% over the last three decades resulting in EAC being identified as the fastest increasing of all cancer types in the US. Esophageal cancer is an extremely deadly malignancy with 5-year survival rates consistently under 20%. The precise reasons for increasing rates of EAC are an active area of investigation ...

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    20. Horizon Technology Finance Leads $15 Million Venture Loan Facility for NinePoint Medical

      Horizon Technology Finance Leads $15 Million Venture Loan Facility for NinePoint Medical

      Horizon Technology Finance Corporation ("Horizon") ( HRZN ), a leading specialty finance company that provides capital in the form of secured loans to venture capital backed companies in the technology, life science, healthcare information and services, and cleantech industries, today announced it has led a $15 million venture loan facility for NinePoint Medical, Inc. ("NinePoint"), an emerging leader in the development of medical devices for advanced optical imaging. NinePoint will use the proceeds for working capital purposes. Horizon funded an initial $5 million of its $7.5 million commitment under the venture loan facility. "We are pleased to lead a $15 million ...

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    21. Integrated Ultrasound And Optical Coherence Tomography (OCT) Endoscope For Image Guided Cancer Biopsy - Available technology for licensing from the University of California, Irvine

      Integrated Ultrasound And Optical Coherence Tomography (OCT) Endoscope For Image Guided Cancer Biopsy - Available technology for licensing from the University of California, Irvine

      Gastrointestinal cancers are very difficult to diagnosis due to poor biopsy and diagnosis techniques. The invention is a device that is minimally invasive and improves biopsy technique by enabling the physician to visualize a tissue in real time prior to its biopsy. This allows for improved biopsy collection and thereby increases the diagnosis accuracy. FULL DESCRIPTION Gastrointestinal (GI) cancers cause 140,000 deaths and more than 290,000 new cases in the US in 2014. These include esophageal, colorectal cancer and many others. The current standard for early diagnosis of GI cancers is to perform histological analysis based on biopsy ...

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    22. Advanced Endoscopic Imaging in the Upper Gastrointestinal Tract (Book)

      Advanced Endoscopic Imaging in the Upper Gastrointestinal Tract (Book)

      Advanced endoscopic imaging incorporates several methods to enhance visualization of the upper gastrointestinal tract. It is an evolving field within advanced endoscopy and particularly important for the endoscopist performing ESD, as these modalities can aid all stages of ESD. Advanced imaging involves several different techniques, from chromoendoscopy (e.g. Lugol’s solution, methylene blue, indigo carmine), to optical enhancement methods (e.g. magnified endoscopy, narrow band imaging, confocal endomicroscopy) and electronic methods (e.g. spectrometry, optical coherence tomography). Frequently, a combination of techniques is utilized to maximize visualization of the lesion and surrounding mucosa. The endoscopist performing ESD needs to ...

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    23. In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis

      In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis

      Background and Objective Development of miniaturized imaging systems with molecular probes enables examination of molecular changes leading to initiation and progression of colorectal cancer in an azoxymethane (AOM)-induced mouse model of the disease. Through improved and novel studies of animal disease models, more effective diagnostic and treatment strategies may be developed for clinical translation. We introduce use of a miniaturized multimodal endoscope with lavage-delivered fluorescent probes to examine dynamic microenvironment changes in an AOM-treated mouse model. Study Design/Materials and Methods The endoscope is equipped with optical coherence tomography (OCT) and laser induced fluorescence (LIF) imaging modalities. It is ...

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    24. Simultaneous dual-band optical coherence tomography for endoscopic applications

      Simultaneous dual-band optical coherence tomography for endoscopic applications

      Dual-band optical coherence tomography (OCT) can greatly enhance the imaging contrast with potential applications in functional (spectroscopic) analysis. A new simultaneous dual-band Fourier domain mode-locked swept laser configuration for dual-band OCT is reported. It was based on a custom-designed dual-channel driver to synchronize two different wavelength bands at 1310 and 1550 nm, respectively. Two lasing wavelengths were swept simultaneously from 1260 to 1364.8 nm for the 1310-nm band and from 1500 to 1604 nm for the 1550-nm band at an A-scan rate of 45 kHz. Broadband wavelength-division multiplexing was utilized to couple two wavelength bands into a common catheter ...

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