1. Articles in category: Gastroenterology

    1-24 of 446 1 2 3 4 ... 17 18 19 »
    1. Postdoctoral Position for the Development of Advanced Optical Technologies in Gastrointestinal Diseases : Erlangen, Germany

      Postdoctoral Position for the Development of Advanced Optical Technologies in Gastrointestinal Diseases : Erlangen, Germany

      As part of the Erlangen Graduate School in Advanced Optical Technologies ( SAOT ) granted by the German Excellence Initiative for Cutting-Edge Research at Institutions of Higher Education, the research group of SAOT Juniorprofessor Maximilian Waldner invites applications for a Postdoc Position Research focus of the Lab/Research projects: The research group focuses on the implementation of new optical technologies for the diagnosis and treatment of gastrointestinal diseases. Current projects evaluate the potential of multiphoton microscopy, optical coherence tomography, hyper-spectral imaging techniques, Raman spectroscopy etc. in preclinical models of inflammatory diseases and cancer of the gastrointestinal tract. Prerequisites for the position are ...

      Read Full Article
    2. Emerging Enhanced Imaging Technologies of the Esophagus: Spectroscopy, Confocal Laser Endomicroscopy, and Optical Coherence Tomography

      Emerging Enhanced Imaging Technologies of the Esophagus: Spectroscopy, Confocal Laser Endomicroscopy, and Optical Coherence Tomography

      Introduction Despite advances in diagnoses and therapy, esophageal adenocarcinoma remains a highly lethal neoplasm. Hence, a great interest has been placed in detecting early lesions and in the detection of Barrett’s esophagus (BE). Advanced imaging technologies of the esophagus have then been developed with the aim of improving biopsy sensitivity and detection of pre- and neoplastic cells. The purpose of this manuscript is to review emerging imaging technologies for esophageal pathology, Spectroscopy, Confocal Laser Endomicroscopy (CLE), and Optical Coherence Tomography (OCT). Methods We conducted a PubMed search using the search string: (esophagus OR esophageal OR oesophageal OR oesophagus) AND ...

      Read Full Article
    3. Medical College of Wisconsin Receives NIH Grant to study Inhibition of Reflux-Induced Esophageal Adenocarinoma by Proanthocyanidins.

      Medical College of Wisconsin Receives NIH Grant  to study Inhibition of Reflux-Induced Esophageal Adenocarinoma by Proanthocyanidins.

      Medical College of Wisconsin Received a 2015 NIH Grant for $317,475 to study Inhibition of Reflux-Induced Esophageal Adenocarinoma by Proanthocyanidins. The prinipal investigator is Laura Kreesty. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. Esophageal adenocarcinoma (EAC) rates have increased 500% over the last three decades resulting in EAC being identified as the fastest increasing of all cancer types in the US. Esophageal cancer is an extremely deadly malignancy with 5-year survival rates consistently under 20%. The precise reasons for increasing rates of EAC are an active area of investigation ...

      Read Full Article
    4. Horizon Technology Finance Leads $15 Million Venture Loan Facility for NinePoint Medical

      Horizon Technology Finance Leads $15 Million Venture Loan Facility for NinePoint Medical

      Horizon Technology Finance Corporation ("Horizon") ( HRZN ), a leading specialty finance company that provides capital in the form of secured loans to venture capital backed companies in the technology, life science, healthcare information and services, and cleantech industries, today announced it has led a $15 million venture loan facility for NinePoint Medical, Inc. ("NinePoint"), an emerging leader in the development of medical devices for advanced optical imaging. NinePoint will use the proceeds for working capital purposes. Horizon funded an initial $5 million of its $7.5 million commitment under the venture loan facility. "We are pleased to lead a $15 million ...

      Read Full Article
    5. Integrated Ultrasound And Optical Coherence Tomography (OCT) Endoscope For Image Guided Cancer Biopsy - Available technology for licensing from the University of California, Irvine

      Integrated Ultrasound And Optical Coherence Tomography (OCT) Endoscope For Image Guided Cancer Biopsy - Available technology for licensing from the University of California, Irvine

      Gastrointestinal cancers are very difficult to diagnosis due to poor biopsy and diagnosis techniques. The invention is a device that is minimally invasive and improves biopsy technique by enabling the physician to visualize a tissue in real time prior to its biopsy. This allows for improved biopsy collection and thereby increases the diagnosis accuracy. FULL DESCRIPTION Gastrointestinal (GI) cancers cause 140,000 deaths and more than 290,000 new cases in the US in 2014. These include esophageal, colorectal cancer and many others. The current standard for early diagnosis of GI cancers is to perform histological analysis based on biopsy ...

      Read Full Article
    6. Advanced Endoscopic Imaging in the Upper Gastrointestinal Tract (Book)

      Advanced Endoscopic Imaging in the Upper Gastrointestinal Tract (Book)

      Advanced endoscopic imaging incorporates several methods to enhance visualization of the upper gastrointestinal tract. It is an evolving field within advanced endoscopy and particularly important for the endoscopist performing ESD, as these modalities can aid all stages of ESD. Advanced imaging involves several different techniques, from chromoendoscopy (e.g. Lugol’s solution, methylene blue, indigo carmine), to optical enhancement methods (e.g. magnified endoscopy, narrow band imaging, confocal endomicroscopy) and electronic methods (e.g. spectrometry, optical coherence tomography). Frequently, a combination of techniques is utilized to maximize visualization of the lesion and surrounding mucosa. The endoscopist performing ESD needs to ...

      Read Full Article
    7. In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis

      In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis

      Background and Objective Development of miniaturized imaging systems with molecular probes enables examination of molecular changes leading to initiation and progression of colorectal cancer in an azoxymethane (AOM)-induced mouse model of the disease. Through improved and novel studies of animal disease models, more effective diagnostic and treatment strategies may be developed for clinical translation. We introduce use of a miniaturized multimodal endoscope with lavage-delivered fluorescent probes to examine dynamic microenvironment changes in an AOM-treated mouse model. Study Design/Materials and Methods The endoscope is equipped with optical coherence tomography (OCT) and laser induced fluorescence (LIF) imaging modalities. It is ...

      Read Full Article
    8. Simultaneous dual-band optical coherence tomography for endoscopic applications

      Simultaneous dual-band optical coherence tomography for endoscopic applications

      Dual-band optical coherence tomography (OCT) can greatly enhance the imaging contrast with potential applications in functional (spectroscopic) analysis. A new simultaneous dual-band Fourier domain mode-locked swept laser configuration for dual-band OCT is reported. It was based on a custom-designed dual-channel driver to synchronize two different wavelength bands at 1310 and 1550 nm, respectively. Two lasing wavelengths were swept simultaneously from 1260 to 1364.8 nm for the 1310-nm band and from 1500 to 1604 nm for the 1550-nm band at an A-scan rate of 45 kHz. Broadband wavelength-division multiplexing was utilized to couple two wavelength bands into a common catheter ...

      Read Full Article
    9. Dual optical modality endoscopic imaging of cancer development in the mouse colon

      Dual optical modality endoscopic imaging of cancer development in the mouse colon

      Background and Objective We utilize a miniature, dual-modality endoscope that combines fluorescence-based surface magnifying chromoendoscopy (SMC) and optical coherence tomography (OCT) to follow the anatomical changes that occur during adenoma development in the mouse colon. Materials and Methods Twenty-five mice were treated with the carcinogen azoxymethane (AOM) to induce tumor development in the distal colon, or were treated with saline as control, and were imaged over six months. OCT detects adenoma number with high sensitivity and specificity and can measure lesion size. In methylene blue-lavaged colons, SMC detects changes in the colonic crypts. SMC images of control mouse colons exhibit ...

      Read Full Article
    10. NinePoint Medical Appoints Christopher von Jako, Ph.D., to Chief Executive Officer

      NinePoint Medical Appoints Christopher von Jako, Ph.D., to Chief Executive Officer

      NinePoint Medical, Inc., an emerging leader in the development of medical devices for advanced optical imaging, today announced the appointment of Christopher von Jako, Ph.D., as president and chief executive officer. Dr. von Jako brings to NinePoint Medical more than 20 years of experience in the global medical device industry and has demonstrated success leading and growing the value of organizations with early-stage commercial products. “Chris is a passionate and technology-minded individual who deeply understands the dynamics of today’s medical device field,” said Tom Miller, chairman of NinePoint’s board of directors. “We believe his commercial insights and ...

      Read Full Article
    11. Ultrahigh speed endoscopic optical coherence tomography for gastroenterology

      Ultrahigh speed endoscopic optical coherence tomography for gastroenterology

      We describe an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor imaging catheter. The system had a 600 kHz axial scan rate and 8 µm axial resolution in tissue. Imaging was performed with a 3.2 mm diameter imaging catheter at 400 frames per second with a 12 µm spot size. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing upper and lower endoscopy. The use of distally actuated imaging catheters enabled OCT imaging with more flexibility, such as volumetric imaging ...

      Read Full Article
    12. Miniaturized endoscopic probe for optical coherence tomography with a tiny magnet driving device

      Miniaturized endoscopic probe for optical coherence tomography with a tiny magnet driving device

      This paper proposes an endoscopic probe for optical coherence tomography (OCT) applying on side-imaging of internal organs. The probe consists of single-mode fiber, a gradient-index (GRIN) lens, and a mirror of cylindrical wedge shape attaching to a magnetized metal piece by epoxy with a short steel wire. For OCT scanning, we use magnetic field generated by a larger magnet externally to drive the rotation of the magnetized metal. Compare with other probes, our probe design has two distinct advantages: 1) The exit beam will be unobstructed during 360 degree circumference scanning because there are no connecting wires in the scanning ...

      Read Full Article
    13. Endoscopic imaging in Barrett's esophagus

      Endoscopic imaging in Barrett's esophagus

      Barrett’s esophagus is the only known precursor that predisposes patients to the development of esophageal adenocarcinoma. The current recommended surveillance method is targeted biopsies of any abnormalities followed by random four-quadrant biopsies every 2 cm using standard white light endoscopy. Compliance with this and sampling error are two of the biggest problems. Several novel imaging technologies have been developed to aid the diagnosis of early neoplasia in Barrett’s esophagus. There are emerging data that some of these new modalities can increase the yield of detecting dysplasia. This review will discuss some of the present available techniques and technologies ...

      Read Full Article
    14. Endoscopic Eradication Therapy for Barrett's Esophagus

      Endoscopic Eradication Therapy for Barrett's Esophagus

      B arrett’s esophagus (BE) is the precursor lesion to esophageal adenocarcinoma, which in an invasive stage causes significant morbidity and mortality. Surgery was the mainstay of treatment for patients with high-grade dysplasia (HGD) and adenocarcinoma associated with BE. However, surgery in itself carries substantial morbidity. There has been tremendous progress in the minimally invasive treatment of BE in the past decade. The premise to be aggressive in treating dysplastic BE and early-stage adenocarcinoma is to prevent progression to an advanced-stage cancer. Most interventional endoscopists are comfortable treating dysplasia and intramucosal esophageal cancer, although recently there have been emerging data ...

      Read Full Article
    15. Advanced Colonoscopic Imaging: Do New Technologies Improve Adenoma Detection?

      Advanced Colonoscopic Imaging: Do New Technologies Improve Adenoma Detection?

      C olorectal cancer (CRC) is the second leading cause of cancer-related mortality in the Western world. 1 Screening colonoscopy and polypectomy have become widely accepted as the most effective available methods for early detection and prevention of CRC and have shown a reduction in mortality in the screened population. 2 However, colonoscopy remains imperfect and several studies have raised concerns about the miss rate of adenomatous polyps during screening. The overall miss rate is approximately 20%, and ranges from 6% for large (10 mm) adenomas to 26% for diminutive (<5 mm) lesions. 3 Missing these adenomas is one of the ...

      Read Full Article
    16. Endoscopic optical coherence tomography as a tool to evaluate successful myotomy after a peroral endoscopic myotomy

      Endoscopic optical coherence tomography as a tool to evaluate successful myotomy after a peroral endoscopic myotomy

      Optical coherence tomography (OCT) provides imaging depth down to 3 mm and resolution of 7 μm over a 6-cm length over a 90 second scan. It is used to analyze tissue microstructure to scan for any potential abnormalities in the esophagus. As of now, the utility of OCT in assessing the esophageal muscular layers in achalasia patients after a peroral endoscopic myotomy (POEM) procedure has not been assessed. We present a case in which this device was used for this indication.

      Read Full Article
    17. Endoscopy for diagnosis and treatment in esophageal cancers: high-technology assessment

      Endoscopy for diagnosis and treatment in esophageal cancers: high-technology assessment

      The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the endoscopic tools to recognize squamous cell dysplasia; confocal laser endomicroscopy for Barrett's esophagus; confocal microscopy in the cancer patient; optical coherence tomography in the assessment of subsquamous Barrett's metaplasia; endoscopic mucosal resection for high-grade dysplasia in Barrett's esophagus; HALO in the treatment of squamous dysplasia; and the use of fluorescence in situ hybridization to detect dysplasia and adenocarcinoma in patients with Barrett's esophagus.

      Read Full Article
    18. A feasibility study of full-field optical coherence tomography for rapid evaluation of EUS-guided microbiopsy specimens

      A feasibility study of full-field optical coherence tomography for rapid evaluation of EUS-guided microbiopsy specimens

      Background Rapid on-site evaluation of cytologic specimens is a way of determining the adequacy of fine-needle aspiration (FNA). However, alternatives may be useful when the presence of a cytotechnologist and/or pathologist is not possible. Objective To evaluate the feasibility of using full-field optical coherence tomography (FFOCT) for FNA specimen quality assessment. Design FFOCT images were acquired on gastric, pancreatic, pelvic, and lymph-node formalin-fixed FNA specimens and were compared with histology of the same samples. Setting Pathology suite in a hospital. Patients Fourteen patients undergoing gastric, pancreatic, pelvic, or lymph-node EUS-guided FNA biopsy. Interventions FFOCT imaging on formalin-fixed samples before ...

      Read Full Article
    19. Endoscopic Optical Coherence Angiography Enables 3-Dimensional Visualization of Subsurface Microvasculature

      Endoscopic Optical Coherence Angiography Enables 3-Dimensional Visualization of Subsurface Microvasculature

      Endoscopic imaging technologies such as confocal laser endomicroscopy 1 and narrow band imaging (NBI) 2 have been used to investigate vascular changes as hallmarks of early cancer in the gastrointestinal tract. However, the limited frame rate and field of view make confocal laser endomicroscopy imaging sensitive to motion artifacts, whereas NBI has limited resolution and visualizes only the surface vascular pattern. Endoscopic optical coherence tomography (OCT) enables high-speed volumetric imaging of subsurface features at near-microscopic resolution, 3,4 and can image microvasculature without exogenous contrast agents, 5 such as fluorescein, which obliterates the image in areas of bleeding, or after ...

      Read Full Article
    20. Noninvasive Esophageal Cancer Imaging 2014 R&D 100 Winner

      Noninvasive Esophageal Cancer Imaging 2014 R&D 100 Winner

      2014 R&D 100 Winner There are two forms of esophageal cancer: squamous cell carcinoma and adenocarcinoma. Adenocarcinoma is increasing at a rate greater than all other cancers in the U.S. In fact, the American Cancer Society estimated that in 2013, nearly 18,000 new cases of esophageal cancer cases will be diagnosed and more than 15,000 people will die from the condition. Currently, imaging and screening practices of esophageal tissue are time consuming and costly with questionable effectiveness. For the patient, this process is also invasive. However, NinePoint Medical and Farm Design have developed a solution, the ...

      Read Full Article
    21. Optical biopsy approaches in Barrett’s esophagus with next-generation optical coherence tomography

      Optical biopsy approaches in Barrett’s esophagus with next-generation optical coherence tomography

      During endoscopic surveillance and treatment in Barrett’s esophagus, the endoscopist may use a combination of tools to assist in targeting biopsies and endoscopic resections in order to diagnose and treat Barrett’s esophagus–associated neoplasia. There is a concern for subepithelial metaplasia or neoplasia in both naïve and previously treated Barrett’s esophagus. Tools to characterize so-called buried disease may allow for improved detection of occult disease. Optical biopsy with volumetric laser endomicroscopy, or VLE, is based on optical coherence tomography.

      Read Full Article
    22. Strategies for the prevention of oesophageal adenocarcinoma

      Strategies for the prevention of oesophageal adenocarcinoma

      The incidence of oesophageal adenocarcinoma has increased by 500% over the past 30 years [1] . Improved understanding of the mechanisms of neoplastic progression provides an opportunity to reverse this trend. A thorough review of emerging strategies aiming to prevent the formation of oesophageal malignancy is presented. These include dietary modification, chemoprevention, early endoscopic identification and treatment of premalignant disease, and the potential for a non-endoscopic screening test. Oesophageal adenocarcinoma has become a major public health problem in the West and it is essential that clinicians are fully informed of risk reduction strategies so that they can be actively promoted in ...

      Read Full Article
    23. MIT Receives NIH Grant for Optical Biopsy Using Optical Coherence Tomography

      MIT Receives NIH Grant for Optical Biopsy Using Optical Coherence Tomography

      Massachusetts Institute of Technology Received a 2014 NIH Grant for $302,576 for Optical Biopsy Using Optical Coherence Tomography. THe principal investigator is James Fujimoto. The program began in 1997 and ends in 2019. Below is a summary of the proposed work. This is a multidisciplinary collaboration between investigators at the Massachusetts Institute of Technology and the VA Boston Healthcare System integrating imaging technology research, clinical imaging studies, medical device development and animal imaging studies. Esophageal cancer is a lethal malignancy, with a five-year survival rate of 16%. Barrett's esophagus (BE) and dysplasia are precursors to esophageal adenocarcinoma (EAC ...

      Read Full Article
    24. Forward viewing OCT endomicroscopy (Thesis)

      Forward viewing OCT endomicroscopy (Thesis)

      A forward viewing fiber optic-based imaging probe device was designed and constructed for use with ultrahigh speed optical coherence tomography in the human gastrointestinal tract. The light source was a MEMS-VCSEL at 1300 nm wavelength running at 300 kHz sweep rate, giving an effective A-line rate of 600 kHz. Data was acquired with a 1.8 GS/s A/D card optically clocked by a maximum fringe frequency of 1 GHz. The optical beam from the probe was scanned by a freely deflecting optical fiber that was mounted proximally on a piezoelectric tubular actuator, which was electrically driven in two ...

      Read Full Article
    1-24 of 446 1 2 3 4 ... 17 18 19 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (1 articles) National Institutes of Health
    2. (1 articles) University of Wisconsin
  4. OCT Companies in the News

    1. (1 articles) NinePoint Medical