1. Articles in category: Gastroenterology

    1-24 of 413 1 2 3 4 ... 16 17 18 »
    1. Optical frequency domain imaging in patients with Barrett's neoplasia: an ex vivo case study with correlated endoscopic and histology views

      Optical frequency domain imaging in patients with Barrett's neoplasia: an ex vivo case study with correlated endoscopic and histology views

      This video (, available online at www.giejournal.org) describes the optical frequency domain interferometry (OFDI) imaging technique, which is a U.S. Food and Drug Administration–approved and commercially available second-generation of optical coherence tomography, and its close correlation with endoscopic views and histopathology results in patients with Barrett's esophagus.

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      Mentions: FDA
    2. Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomograph

      Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomograph

      Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to study colorectal cancer (CRC) and pancreatic cancer (PC) field carcinogenesis. Depth-resolved optical and ultrastructural properties of the mucosa were quantified from histologically normal rectal biopsies from patients with and without colon adenomas ( n = 85 ) as well as from histologically normal peri-ampullary duodenal biopsies from patients with and without PC ( n = 22 ). Changes in the epithelium and stroma in CRC field carcinogenesis were separately quantified. In both compartments, optical and ultra-structural ...

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    3. NinePoint Medical Completes $34 Million Series B Financing to Expand Commercialization of its Breakthrough NvisionVLE™ Imaging System

      NinePoint Medical Completes $34 Million Series B Financing to Expand Commercialization of its Breakthrough NvisionVLE™ Imaging System

      NinePoint Medical, Inc. , an emerging leader in the development of medical devices for advanced optical imaging, today announced it has completed a $34 million Series B financing led by Corning Incorporated (NYSE: GLW), along with founding investors Third Rock Ventures and Prospect Venture Partners. The company also announced the addition of three new members to its board of directors: Curt Weinstein from Corning, and independent directors Tom Miller and Mark Stautberg. Proceeds from the financing will support the ongoing commercial launch of the NvisionVLE Imaging System in the U.S., as well as development of the company’s expanded product ...

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    4. Swept-source common-path optical coherence tomography with a MEMS endoscopic imaging probe

      Swept-source common-path optical coherence tomography with a MEMS endoscopic imaging probe

      A MEMS-based common-path endoscopic imaging probe for 3D swept-source optical coherence tomography (SSOCT) has been developed. The common path is achieved by setting the reference plane at the rear surface of the GRIN lens inside the probe. MEMS devices have the advantages of low cost, small size and fast speed, which are suitable for miniaturizing endoscopic probes. The aperture size of the two-axis MEMS mirror employed in this endoscopic probe is 1 mm by 1 mm and the footprint of the MEMS chip is 1.55 mm by 1.7 mm. The MEMS mirror achieves large two dimensional optical scan ...

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    5. Korea Research Team Develops Tech for 3D Blood Vessel Endoscope

      Korea Research Team Develops Tech for 3D Blood Vessel Endoscope

      The Korea Advanced Institute of Science and Technology (KAIST) announced on March 12 that a research team lead by Professor Oh Wang-yuhl from the Department of Mechanical Engineering at KAIST has developed a technology to make a world-class blood vessel endoscope system. The diagnostic imaging technology provides cross-sectional images of the blood vessel walls, up to 3.5 times faster than using the existing blood vessel endoscope system. Therefore, the tech is expected to help in diagnosing and treating cardiovascular diseases. The new optical coherence tomography (OCT) is a method that captures micrometer-resolution, three-dimensional images of blood vessels by inserting ...

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    6. Combined information from Raman spectroscopy and optical coherence tomography for enhanced diagnostic accuracy in tissue discrimination

      Combined information from Raman spectroscopy and optical coherence tomography for enhanced diagnostic accuracy in tissue discrimination

      Optical spectroscopy and imaging methods have proved to have potential to discriminate between normal and abnormal tissue types through minimally invasive procedures. Raman spectroscopy and Optical Coherence Tomography (OCT) provides chemical and morphological information of tissues respectively, which are complementary to each other. When used individually they might not be able to obtain high enough sensitivity and specificity that is clinically relevant. In this study we combined Raman spectroscopy information with information obtained from OCT to enhance the sensitivity and specificity in discriminating between Colonic Adenocarcinoma from Normal Colon. OCT being an imaging technique, the information from this technique is ...

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    7. Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter

      Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter

      We developed an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor based imaging catheter, which provided an imaging speed of 600 kHz axial scan rate and 8 μm axial resolution in tissue. The micromotor catheter was 3.2 mm in diameter and could be introduced through the 3.7 mm accessory port of an endoscope. Imaging was performed at 400 frames per second with an 8 μm spot size using a pullback to generate volumetric data over 16 mm with a pixel spacing of 5 μm in ...

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    8. Endoscopic Optical Coherence Tomography (OCT): Advances in Gastrointestinal Imaging

      Endoscopic Optical Coherence Tomography (OCT): Advances in Gastrointestinal Imaging

      In the rapidly evolving field of endoscopic gastrointestinal imaging, Optical Coherence Tomography (OCT) has found many diverse applications. We present the current status of OCT and its practical applications in imaging normal and abnormal mucosa in the esophagus, stomach, small and large intestines, and biliary and pancreatic ducts. We highlight technical aspects and principles of imaging, assess published data, and suggest future directions for OCT-guided evaluation and therapy.

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    9. Recent Advances in Molecular Imaging of Premalignant Gastrointestinal Lesions and Future Application for Early Detection of Barrett Esophagus

      Recent Advances in Molecular Imaging of Premalignant Gastrointestinal Lesions and Future Application for Early Detection of Barrett Esophagus

      Recent advances in optical molecular imaging allow identification of morphologic and biochemical changes in tissues associated with gastrointestinal (GI) premalignant lesions earlier and in real-time. This focused review series introduces high-resolution imaging modalities that are being evaluated preclinically and clinically for the detection of early GI cancers, especially Barrett esophagus and esophageal adenocarcinoma. Although narrow band imaging, autofluorescence imaging, and chromoendoscopy are currently applied for this purpose in the clinic, further adoptions of probe-based confocal laser endomicroscopy, high-resolution microendoscopy, optical coherence tomography, and metabolomic imaging, as well as imaging mass spectrometry, will lead to detection at the earliest and will ...

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    10. Controversial Data Show RFA Beneficial for LGD in Barrett's, but Accurate Diagnosis Is Key

      Controversial Data Show RFA Beneficial for LGD in Barrett's, but Accurate Diagnosis Is Key

      Radiofrequency ablation (RFA) in Barrett’s esophagus (BE) patients with low-grade dysplasia (LGD) provides significant protection against progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma, according to the findings of a multicenter, randomized trial presented at the 2013 Digestive Disease Week (DDW) meeting. In fact, the benefit of RFA relative to surveillance alone was so great, that the trial’s safety monitoring committee recommended terminating the trial after an interim analysis. The demonstration that RFA can reduce the risk for progression in patients with LGD has immediate relevance to clinical practice, said the senior author of the study, Jacques J ...

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    11. The Medical College of Wisconsin Receives a NIH Grant for Studying Inhibition of Reflex-Induced Esophageal Adenocarcinoma by Proanthocyanidins

      The Medical College of Wisconsin Receives a NIH Grant for Studying Inhibition of Reflex-Induced Esophageal Adenocarcinoma by Proanthocyanidins

      The Medical College of Wisconsin Received a 2014 NIH Grrant for $285,728 for Studying Inhibition of Reflex-Induced Esophageal Adenocarcinoma by Proanthocyanidins. The principal investigator is Laura Kresty. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. Esophageal adenocarcinoma (EAC) rates have increased 500% over the last three decades resulting in EAC being identified as the fastest increasing of all cancer types in the US. Esophageal cancer is an extremely deadly malignancy with 5-year survival rates consistently under 20%. The precise reasons for increasing rates of EAC are an active area of ...

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    12. Advanced Imaging Technologies for the Detection of Dysplasia and Early Cancer in Barrett Esophagus

      Advanced Imaging Technologies for the Detection of Dysplasia and Early Cancer in Barrett Esophagus

      Abstract Advanced esophageal adenocarcinomas arising from Barrett esophagus (BE) are tumors with an increasing incidence and poor prognosis. The aim of endoscopic surveillance of BE is to detect dysplasia, particularly high-grade dysplasia and intramucosal cancers that can subsequently be treated endoscopically before progression to invasive cancer with lymph node metastases. Current surveillance practice standards require the collection of random 4-quadrant biopsy specimens over every 1 to 2 cm of BE (Seattle protocol) to detect dysplasia with the assistance of white light endoscopy, in addition to performing targeted biopsies of recognizable lesions. This approach is labor-intensive but should currently be considered ...

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    13. Characterization of eosinophilic esophagitis murine models using optical coherence tomography

      Characterization of eosinophilic esophagitis murine models using optical coherence tomography

      Pre-clinical studies using murine models are critical for understanding the pathophysiological mechanisms underlying immune-mediated disorders such as Eosinophilic esophagitis (EoE). In this study, an optical coherence tomography (OCT) system capable of providing three-dimensional images with axial and transverse resolutions of 5 µm and 10 µm, respectively, was utilized to obtain esophageal images from a murine model of EoE-like disease ex vivo . Structural changes in the esophagus of wild-type ( Tslpr +/+ ) and mutant ( Tslpr −/− ) mice with EoE-like disease were quantitatively evaluated and food impaction sites in the esophagus of diseased mice were monitored using OCT. Here, the capability of OCT as a ...

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    14. Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study

      Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study

      Background Biopsy surveillance protocols for the assessment of Barrett's esophagus can be subject to sampling errors, resulting in diagnostic uncertainty. Optical coherence tomography is a cross-sectional imaging technique that can be used to conduct volumetric laser endomicroscopy (VLE) of the entire distal esophagus. We have developed a biopsy guidance platform that places endoscopically visible marks at VLE-determined biopsy sites. Objective The objective of this study was to demonstrate in human participants the safety and feasibility of VLE-guided biopsy in vivo. Design A pilot feasibility study. Setting Massachusetts General Hospital. Patients A total of 22 participants were enrolled from January ...

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    15. Evaluation of ultrasound and glucose synergy effect on the optical clearing and light penetration for human colon tissue using SD-OCT

      Evaluation of ultrasound and glucose synergy effect on the optical clearing and light penetration for human colon tissue using SD-OCT

      Topical application optical clearing agents (OCAs) can effectively enhance the tissue optical clearing on the human colon tissue, which has been demonstrated in our previous studies. Nevertheless, the strong light scattering still limits the diffusion rate of OCAs and penetration depth of light into the tissue. In this study, in order to further increase the diffusion of the OCA of glucose into tissue, we employ a method to improve the glucose permeability and light penetration with ultrasound (sonophoretic delivery, SP) and glucose (G) synergy on human normal and cancerous colon tissues in vitro, which was measured and quantified with spectral-domain ...

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    16. Deep-Tissue Dysplasia Detection with Real-Time Subcellular Analysis

      Deep-Tissue Dysplasia Detection with Real-Time Subcellular Analysis

      Angle-resolved low coherence interferometry (a/LCI) directly measures diagnostically relevant sub-cellular features in epithelial tissues up to 500 μm below the surface. Unlike optical coherence tomography (OCT), which requires image interpretation, a/LCI performs analysis of tissue and delivers to the physician direct confirmation of precancerous disease. Because it offers the greatest opportunity for successful intervention and therapy, a key weapon in the fight against cancer is early detection. If disease can be found in the precancerous stage, before abnormal cells have had the chance to spread throughout the body, the efficacy of treatment can be quite high. The clinical ...

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    17. Endoscopic mucosal resection of Barrett’s esophagus detects high prevalence of subsquamous intestinal metaplasia

      Endoscopic mucosal resection of Barrett’s esophagus detects high prevalence of subsquamous intestinal metaplasia

      AIM: To report the prevalence of Subsquamous intestinal metaplasia (SSIM) in patients undergoing endoscopic mucosal resection (EMR) for staging of Barrett’s esophagus (BE). METHODS: Thirty-three patients with BE associated neoplasia underwent EMR at our institution between September 2009 and September 2011; 22 of these patients met study inclusion criteria. EMR was targeted at focal abnormalities within the BE segment. EMR was performed in standardized fashion using a cap-assisted band ligation technique, and resection specimens were assessed for the presence of SSIM. Demographic and clinical data were analyzed to determine predictors of SSIM. RESULTS: SSIM was detected in 59% of ...

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    18. Endoscopic tools for the diagnosis and evaluation of celiac diseas

      Endoscopic tools for the diagnosis and evaluation of celiac diseas

      Celiac disease (CD) is an autoimmune disease of the small bowel induced by ingestion of wheat, rye and barley. Current guidelines indicate histological analysis on at least four duodenal biopsies as the only way to diagnose CD. These indications are based on the conception of the inability of standard endoscopy to make diagnosis of CD and/or to drive biopsy sampling. Over the last years, technology development of endoscopic devices has greatly ameliorated the accuracy of macroscopic evaluation of duodenal villous pattern, increasing the diagnostic power of endoscopy of CD. The aim of this paper is to review the new ...

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    19. Covidien Announces Definitive Agreement to Acquire Given Imaging for $860M

      Covidien Announces Definitive Agreement to Acquire Given Imaging for $860M

      Covidien Announces Definitive Agreement to Acquire Given Imaging Advances Covidien strategy to more comprehensively address key specialties and procedures globally Adds Given Imaging’s broad suite of minimally invasive gastrointestinal diagnostic and monitoring solutions Accelerates development of world-class gastrointestinal portfolio focused on serving patient from diagnosis to treatment Accretive to earnings per share beginning in fiscal 2015 Covidien plc (NYSE: COV) and Given Imaging Ltd . (Nasdaq: GIVN) today announced a definitive agreement under which Covidien will acquire all of the outstanding shares of Given Imaging for $30.00 per share in cash, for a total of approximately $860 million, net ...

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    20. Diagnostic Endoscopy (Textbook)

      Diagnostic Endoscopy (Textbook)

      Combining a professional development course on diagnostic endoscopy from SPIE (the international society advancing light-based research) and the authors’ graduate course on biomedical optics, this work is written for researchers in medical optics and biomedical engineering as well as graduate medical optics students. It uses extensive examples/case studies to familiarize readers with the basics of endoscopic optics, the pros and cons of white light endoscopy and fluorescence endoscopy for diagnostic applications, and various microscopic endoscopy imaging modalities. It covers basic optics, details of design and biomedical uses, as well as microscopic endoscopy, and endoscopic spectroscopy.

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    21. Imaging pancreatobiliary ductal system with optical coherence tomography: A review

      Imaging pancreatobiliary ductal system with optical coherence tomography: A review

      An accurate, noninvasive and cost-effective method of in situ tissue evaluation during endoscopy would be highly advantageous for the detection of dysplasia or early cancer and for identifying different disease stages. Optical coherence tomography (OCT) is a noninvasive, high-resolution (1-10 μm) emerging optical imaging method with potential for identifying microscopic subsurface features in the pancreatic and biliary ductal system. Tissue microstructure of pancreaticobiliary ductal system has been successfully imaged by inserting an OCT probe through a standard endoscope operative channel. High-resolution OCT images and the technique’s endoscopic compatibility have allowed for the microstructural diagnostic of the pancreatobiliary diseases. In ...

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    22. British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus

      British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus

      These guidelines provide a practical and evidence-based resource for the management of patients with Barrett's oesophagus and related early neoplasia. The Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument was followed to provide a methodological strategy for the guideline development. A systematic review of the literature was performed for English language articles published up until December 2012 in order to address controversial issues in Barrett's oesophagus including definition, screening and diagnosis, surveillance, pathological grading for dysplasia, management of dysplasia, and early cancer including training requirements. The rigour and quality of the studies was evaluated using the ...

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    23. Feature Of The Week 10/27/13: University of St. Andrews Reports on Multi-Modal OCT and Raman Discrimination of Colon Cancer

      Feature Of The Week 10/27/13: University of St. Andrews Reports on Multi-Modal OCT and Raman Discrimination of Colon Cancer

      Raman spectroscopy and Optical Coherence Tomography (OCT) are two optical tools that have shown potential to be used for discriminating between normal and abnormal tissue types. Although both of these non-invasive techniques are capable of discriminating between normal and tumour tissues, in many cases, they are unable individually to provide both the high specificity and high sensitivity required for disease diagnosis. Raman spectroscopy and OCT provides complementary information. While Raman spectroscopy provides information about chemical composition of tissues, OCT provides morphological information of tissues. So combining this complementary information might be able to provide higher diagnostic accuracy that is clinically ...

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    24. Image-based noninvasive evaluation of colorectal mucosal injury in sheep after topical application of microbicides

      Image-based noninvasive evaluation of colorectal mucosal injury in sheep after topical application of microbicides

      Background: Successful development of topical rectal microbicides requires preclinical evaluation in suitable large animal models. Our previous studies have demonstrated the benefits of high-resolution optical coherence tomography (OCT) to visualize subclinical microbicide toxicity in the sheep vagina. In the current study, we evaluated the potential application of colonoscopy and OCT to visualize and quantify the effects of topical products on sheep colorectal tissue, as assessed by advanced imaging techniques. Methods: Yearling virginal female sheep were treated rectally with a single 8-mL dose of 0.2% benzalkonium chloride (BZK) solution or phosphate-buffered saline control. Imaging was performed before and 30 minutes ...

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    1-24 of 413 1 2 3 4 ... 16 17 18 »
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