Gastroenterology -Optical Coherence Tomography News

Articles in category: Gastroenterology

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1. NinePoint Medical launches esophageal imaging system
  
  Explore bizjournals May 16 2013 Gastroenterology , Other Business News
  
  Cambridge medical device company NinePoint Medical Inc. on Thursday launched its lead product in the U.S., an imaging system that makes it easier to examine and detect diseases of the esophagus. NinePoint’s proprietary NvisionVLE Imaging System was granted 510(k) clearance in December 2011 to be used as an imaging tool in the evaluation of human tissue microstructure. Last month, it received additional clearance to to include imaging of esophageal tissue microstructure. In June 2012, the device received European CE mark approval .
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  Mentions: Massachusetts General Hospital NinePoint Medical
2. Subsquamous intestinal metaplasia after ablation of Barrett's esophagus: frequency and importance
  
  Explore LWW Online May 16 2013 Gastroenterology , Oncology
  
  Purpose of review: This article reviews reports on the prevalence of subsquamous intestinal metaplasia (SSIM) in patients with Barrett's esophagus, and the implications of SSIM in the neoplastic progression of Barrett's esophagus to esophageal adenocarcinoma. Recent findings: Endoscopic eradication therapy for dysplastic Barrett's esophagus has become an encouraging alternative to esophagectomy or continued endoscopic surveillance. However, the presence of SSIM before and after ablation is concerning because this tissue may have potential for malignant progression, is not visible by conventional endoscopy, and may evade detection by random esophageal biopsy sampling methods. Advances in endoscopic high-resolution three-dimensional optical ...
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  Mentions: Harvard University Hiroshi Mashimo
3. NinePoint Medical Announces U.S. Commercial Availability of the NvisionVLE™ Imaging System
  
  Explore Optical Coherence Tomography News May 16 2013 Gastroenterology , Other Business News
  
  NinePoint Press Release - NinePoint Medical, Inc., an emerging leader in the development of medical devices for advanced optical imaging, today announced the commercial launch of its proprietary NvisionVLE ™ Imaging System in the United States. In addition, NinePoint today announced the launch of its newly redesigned website, www.ninepointmedical.com . In December 2011, the NvisionVLE Imaging System received 510(k) clearance from the U.S. Food and Drug Administration for use as an imaging tool in the evaluation of human tissue microstructure by providing two-dimensional, cross sectional, real-time depth visualization. Last month, NinePoint received 510(k) clearance to expand the System ...
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  Mentions: Massachusetts General Hospital FDA NinePoint Medical
4. Optical Molecular Imaging in the Gastrointestinal Tract
  
  Explore giendo.theclinics.com May 15 2013 Gastroenterology
  
  Recent developments in optical molecular imaging allow for real-time identification of morphologic and biochemical changes in tissue associated with gastrointestinal neoplasia. This review summarizes widefield and high-resolution imaging modalities in preclinical and clinical evaluation for the detection of colorectal cancer and esophageal cancer. Widefield techniques discussed include high-definition white light endoscopy, narrow band imaging, autofluoresence imaging, and chromoendoscopy; high-resolution techniques discussed include probe-based confocal laser endomicroscopy, high-resolution microendoscopy, and optical coherence tomography. New approaches to enhance image contrast using vital dyes and molecular-specific targeted contrast agents are evaluated.
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  Mentions: Rebecca Richards-Kortum Rice University
5. Moving Towards 'Smart' Endoscopy
  
  Explore optics.org May 15 2013 Gastroenterology
  
  Surgeons addressing delegates at the LASER World of Photonics trade show in Munich expressed their need for “smarter” endoscopes with the capability of real-time detection of normal and abnormal cells. Orlando Guntinas-Lichius, a head and neck surgeon at the University Hospital of Jena, said that there was a particularly urgent need for more functional endoscopes to investigate the upper parts of patients’ bodies, and described current technology as something “from the Middle Ages”. While endoscopes have become indispensable tools for clinicians, Guntinas-Lichius said that the most important tool remains the surgeons’ eye, because the endoscope merely allows them a view ...
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6. NinePoint Medical to Present NvisionVLE Clinical Data at Digestive Disease Week 2013
  
  Explore Optical Coherence Tomography News May 13 2013 Gastroenterology , Other Business News
  
  NinePoint Medical Press Release - NinePoint Medical, Inc., an emerging leader in the development of medical devices for in vivo imaging, today announced that new clinical data on its proprietary NvisionVLE ™ Imaging System will be featured in five poster presentations during Digestive Disease Week (DDW) taking place May 18-21, 2013, in Orlando, Fla. In addition, researchers from Massachusetts General Hospital (MGH) will highlight the core imaging technology of NvisionVLE, as well as a follow-on confocal endomicroscopy system, in two oral and two poster presentations. NinePoint licensed the imaging technology from MGH in 2010 as part of the largest intellectual property agreement ...
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  Mentions: Massachusetts General Hospital NinePoint Medical NinePoint Nvision VLE Imaging System
7. In vitro study of the effects of ultrasound-mediated glycerol on optical attenuation of human normaland cancerous esophageal tissues with optical coherence tomography
  
  Explore IOPscience May 8 2013 Gastroenterology , Oncology
  
  Previous studies from our group have demonstrated that glucose solution can induce optical clearing enhancement of esophageal tissues with optical coherence tomography (OCT). The aims of this study were to evaluate the optical clearing effects of ultrasound-mediated optical clearing agents (OCAs) and to find more effective methods to distinguish human normal esophageal tissues (NE) and cancerous esophageal tissues (CE). Here we used the OCT technique to investigate the optical attenuation of NE and CE in vitro after treatment with 30% glycerol alone and glycerol combined with ultrasound, respectively. Experimental results showed that the averaged attenuation coefficient of CE was significantly ...
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  Mentions: Fujian Normal University South China Normal University
8. 3D imaging for faster diagnosis of esophageal disease
  
  Explore Home: SPIE.org May 7 2013 Gastroenterology
  
  A tethered capsule that is swallowed by the patient offers a quick and pain-free method of screening and diagnosing gastrointestinal diseases. Diagnosing gastrointestinal (GI) diseases usually involves endoscopy, combining an invasive probe and video imaging or other optical methods. While effective, this method often causes patient discomfort and typically requires anesthesia, making it costly and time-consuming. Here we describe a new option for screening using a swallowable optomechanically engineered pill that rapidly provides 3D microscopic images of the gastrointestinal tract. The process is pain-free, so there is no need for anesthesia, and enables quick diagnosis of esophageal diseases.
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  Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University
9. NinePoint Medical Receives Additional FDA 510(k) Clearance for NvisionVLE Imaging System
  
  Explore Optical Coherence Tomography News Apr 26 2013 Gastroenterology , Other Business News
  
  NinePoint Medical Press Release - NinePoint Medical, Inc. , an emerging leader in the development of medical devices for in vivo imaging, today announced that it has received an additional 510(k) clearance from the U.S. Food and Drug Administration (FDA) for its NvisionVLE ™ Imaging System, expanding the system’s indication to include imaging of esophageal tissue microstructure. In January 2012, the company announced 510(k) clearance from the FDA to market its NvisionVLE Imaging System for use as an imaging tool in the evaluation of human tissue microstructure by providing two-dimensional, cross sectional, real-time depth visualization. “The NvisionVLE Imaging System ...
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  Mentions: FDA NinePoint Medical Charles Carignan
10. The pill camera that's easy to swallow
  
  Explore money.cnn.com Apr 10 2013 Gastroenterology
  
  An experimental pill technology at Mass General Hospital in Boston could change how throat-scanning endoscopies are done.
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  Mentions: Guillermo J. Tearney Massachusetts General Hospital Norman S. Nishioka
11. Ultrahigh speed endoscopic optical coherence tomography using micro-motor imaging catheter and VCSEL technology
  
  Explore Conference Proceedings Apr 1 2013 Gastroenterology , Probes
  
  We developed a micro-motor based miniature catheter with an outer diameter of 3mm for ultrahigh speed endoscopic optical coherence tomography (OCT) using vertical cavity surface-emitting laser (VCSEL) at a 1MHz axial scan rate. The micro-motor can rotate a micro-prism at 1,200-72,000rpm (corresponding to 20- 1,200fps) with less than 5V driving voltage to provide fast and stable scanning, which is not sensitive to the bending of the catheter. The side-viewing probe can be pulled back for a long distance to acquire three-dimensional (3D) dataset covering a large area on the specimen. VCSEL provides high a-line rate to support ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
12. Interobserver Agreement for the Detection of Barrett’s Esophagus with Optical Frequency Domain Imagin
  
  Explore Home - Springer Mar 20 2013 Gastroenterology
  
  Background Optical frequency domain imaging (OFDI) is a second-generation form of optical coherence tomography (OCT) providing comprehensive cross-sectional views of the distal esophagus at a resolution of ~7 μm. Aim Using validated OCT criteria for squamous mucosa, gastric cardia mucosa, and Barrett’s esophagus (BE), the objective of this study was to determine the inter- and intra-observer agreements by a large number of OFDI readers for differentiating these tissues. Methods OFDI images were obtained from nine subjects undergoing screening and surveillance for BE. Sixty-four OFDI image regions of interest were randomly selected for review. A training set of 19 images ...
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  Mentions: Guillermo J. Tearney Brett E. Bouma Massachusetts General Hospital
13. Spiral-scanning, side-viewing optical coherence tomography endoscope for three-dimensional fully sampled in vivo imaging of the mouse colon
  
  Explore Conference Proceedings Mar 18 2013 Gastroenterology , Probes
  
  We have previously developed side-viewing endoscopic OCT systems to detect colorectal cancer in the murine model, which longitudinally scans the mouse colon at 8-16 discrete angular positions. This small number of angles is chosen to keep imaging time and the amount of data to analyze reasonable, but this azimuthal undersampling of the tissue may result in missed or incorrectly characterized adenomas. A need exists for a spiral-scanning OCT endoscope capable of generating 3D, in vivo OCT data sets that satisfy the Nyquist criterion for adequate sampling of the tissue. Our new endoscopic system replaces the sample arm optics of a ...
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  Mentions: Jennifer K. Barton University of Arizona
14. NinePoint Medical Imaging Technology Profiled in Three Recent Publications
  
  Explore Optical Coherence Tomography News Mar 18 2013 Gastroenterology , Pulmonology
  
  NinePoint Medical Press Release - Data Demonstrates OCT Imaging in Pulmonary Applications NinePoint Medical, Inc. , an emerging leader in the development of medical devices for in vivo imaging, today announced that data featuring its core imaging technologies were recently published in three major pulmonary journals. This research from Massachusetts General Hospital (MGH), highlighting pulmonary applications of advanced optical coherence tomography (OCT) and optical frequency domain imaging (OFDI), was featured in the American Journal of Respiratory and Critical Care Medicine , CHEST and the Journal of Visual Experiments. The technology has been licensed by NinePoint Medical from MGH and is currently in the ...
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  Mentions: Massachusetts General Hospital FDA NinePoint Medical
15. Cancer detection as easy as popping a pill (video)
  
  Explore Business News Mar 14 2013 Gastroenterology
  
  Will Baker is swallowing a pill, but he isn't taking medication. The pill is actually a tiny scanner that will allow his doctor to check his esophagus for signs of cancer. Baker was diagnosed with Barrett's Syndrome in 1996. It's a condition where the lining of the esophagus is replaced by cells normally found in the gastrointestinal tract. The danger with Barrett's is its potential to develop into a deadly form of cancer called esophageal endocarcinoma. Two minutes after swallowing the pill, the doctor pulls it back out using a tether. "I think it is a ...
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  Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University
16. In vivo detection of Hirschsprung's disease by optical coherence tomography in rats
  
  Explore IOPscience Feb 15 2013 Gastroenterology
  
  Hirschsprung's disease (HSCR) is a developmental intestinal obstruction, which is often diagnosed with a repeated biopsy. Optical coherence tomography (OCT) is a noninvasive, real-time imaging modality. This study aims to investigate the feasibility of diagnosis of HSCR, the targeted biopsies of suspicious tissues and the location of operative treatment using OCT. An HSCR Sprague–Dawley (SD) rat model (benzalkonium chloride-treated (BAC-treated)) was used. Colon tissues with BAC-treated and without BAC-treated were imaged using OCT. To establish OCT criteria for identification of HSCR, OCT images were compared with corresponding histology images and muscle layer thickness was measured. Furthermore, attenuation coefficients ...
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  Mentions: South China Normal University
17. Functions and Imaging of Mast Cell and Neural Axis of the Gut
  
  Explore Gastroenterology Jan 27 2013 Gastroenterology
  
  Close association between nerves and mast cells in the gut wall provides the microanatomic basis for functional interactions between these elements, supporting the hypothesis that a mast cell–nerve axis influences gut functions in health and disease. Advanced morphology and imaging techniques are now available to assess structural and functional relationships of the mast cell–nerve axis in human gut tissues. Morphologic techniques including co-labeling of mast cells and nerves serve to evaluate changes in their densities and anatomic proximity. Calcium (Ca ++ ) and potentiometric dye imaging provide novel insights into functions such as mast cell–nerve signaling in the human ...
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  Mentions: Technical University of Munich
18. NinePoint Medical Imaging Technology Highlighted in Nature Medicine
  
  Explore Optical Coherence Tomography News Jan 17 2013 Gastroenterology
  
  NinePoint Medical Press Release - NinePoint Medical, Inc . , an emerging leader in the development of medical devices for in vivo imaging, today announced that data demonstrating positive results related to a new tethered capsule endomicroscopy technology, licensed from Massachusetts General Hospital (MGH), were published online this week in the journal Nature Medicine . The research, performed at the Wellman Center for Photomedicine at MGH, where the technology was developed, shows the pill-sized imaging system creates detailed, microscopic, three-dimensional images of the esophageal wall and is expected to offer several advantages over traditional endoscopy. This tethered capsule endomicroscopy technology has been licensed for ...
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  Mentions: Massachusetts General Hospital NinePoint Medical Charles Carignan
19. Pill-sized device rivals endoscopy: Novel imaging system screens for Barrett’s esophagus in minutes
  
  Explore Optical Coherence Tomography News Jan 14 2013 Gastroenterology
  
  P hysicians may soon have a new way to screen patients for Barrett’s esophagus, a precancerous condition usually caused by chronic exposure to stomach acid. Researchers at the Wellman Center for Photomedicine at Massachusetts General Hospital (MGH) have developed an imaging system enclosed in a capsule about the size of a multivitamin pill that creates detailed, microscopic images of the esophageal wall. The system has several advantages over traditional endoscopy. “This system gives us a convenient way to screen for Barrett’s that doesn’t require patient sedation, a specialized setting and equipment, or a physician who has been ...
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  Mentions: Guillermo J. Tearney Brett E. Bouma National Institutes of Health
20. Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure
  
  Explore Nature Publishing Group Jan 14 2013 Gastroenterology
  
  Here we introduce tethered capsule endomicroscopy, which involves swallowing an optomechanically engineered pill that captures cross-sectional microscopic images of the gut wall at 30 μm (lateral) × 7 μm (axial) resolution as it travels through the digestive tract. Results in human subjects show that this technique rapidly provides three-dimensional, microstructural images of the upper gastrointestinal tract in a simple and painless procedure, opening up new opportunities for screening for internal diseases.
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  Mentions: Guillermo J. Tearney Brett E. Bouma Massachusetts General Hospital
21. Endoscopic Evaluation of Bile Duct Strictures
  
  Explore giendo.theclinics.com Jan 13 2013 Gastroenterology
  
  Differentiating between malignant and benign bile duct strictures is often challenging. Endoscopic retrograde cholangiopancreatography with brush cytology and/or endobiliary forceps biopsy is routinely performed. Advanced cytologic methods such as fluorescence in situ hybridization or digital image analysis increases the sensitivity of cytology. Endoscopic ultrasonography enables detailed examination of tissues surrounding the bile duct stricture and offers the advantage of fine-needle aspiration. Intraductal ultrasonography enables detailed evaluation of bile duct wall layers, and cholangioscopy offers direct visualization of the bile duct lesions. Novel techniques of probe-based confocal laser endomicroscopy and optical coherence tomography have introduced the era of in vivo ...
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  Mentions: Massachusetts General Hospital Harvard University
22. Digital holographic microscopy quantifies degree of inflammation in experimental colitis
  
  Explore RSC Publishing Home Jan 10 2013 Gastroenterology
  
  Inflammatory bowel disease including Crohn’s disease and ulcerative colitis resemble a large burden for patients due to the chronic course of disease. Therefore, there is an urgent need to explore new potential drugs and to develop new treatment options. Usually, evaluation of therapeutic potential is performed in murine models of colitis with the challenge of a valid assessment of the inflammation process and the therapeutic response. Digital holographic microscopy (DHM) enables strain-free quantitative phase contrast imaging and provides tissue density assessment by measuring optical path length delay and accordingly refractive index. Dextran sodium sulphate induced colitis was performed in ...
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23. Forward looking optical coherence tomography endoscope
  
  Explore uspto.gov Dec 4 2012 Gastroenterology , Patents , Probes
  
  A forward-looking, optical coherence tomography, endoscopic probe is disclosed capable of high resolution with a small diameter. Light is focused and scanned during three passes through a lens. A light source supplies light to the proximal side of the lens. The light makes a first pass through the lens, and is reflected from a fixed mirror on the distal side. The reflected light makes a second pass from the distal side to the proximal side, and exits the lens at the proximal side, and is reflected by a scanning mirror. The light makes a third pass through the lens from ...
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24. Barrett's esophagus: should we burn it all?
  
  Explore Gastrointestinal Endoscopy Nov 19 2012 Gastroenterology
  
  Controversy continues on the issue of whether non-neoplastic Barrett's esophagus and Barrett's esophagus with premalignant lesions such as low-grade intraepithelial neoplasia (LGIN) and high-grade intraepithelial neoplasia (HGIN) should be eradicated endoscopically by using ablative methods. The main argument in the past for endoscopic ablation using photodynamic therapy (PDT) or argon plasma coagulation (APC) was that it is capable of preventing cancer, against the background of the dramatic increase in the incidence of esophageal adenocarcinoma during the past few decades. There is no doubt that Barrett's esophagus is a precancerous lesion, and Barrett's with premalignant lesions in ...
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