Gastroenterology -Optical Coherence Tomography News

Articles in category: Gastroenterology

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1. NinePoint Medical Receives NIH Grant for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures
  
  Explore Optical Coherence Tomography News Mar 19 2019 Gastroenterology , Funding
  
  NinePoint Medical Receives a 2019 NIH Grant for $222,020 for An Integrated Optical Coherence Tomography and Tissue Acquisition Device for Diagnostics of Indeterminate Biliary Strictures. The principal investigator is Eman Namati. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. Bile duct strictures can lead to painful clinical symptoms and can be caused by a wide range of conditions from benign diseases to cholangiocarcinoma, a deadly cancer of the bile duct with 5-year survival rates as low as 2% for late stage disease. The management and prognosis of bile duct strictures ...
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  Mentions: National Institutes of Health NinePoint Medical Eman Namati
2. Boston Medical Center Receives NIH Grant for Microvasculature in Colon Field Carcinogenesis: Clinical-Biological Implications
  
  Explore Optical Coherence Tomography News Mar 6 2019 Gastroenterology , Funding
  
  Boston Medical Center Receives a 2019 NIH Grant for $669,582 for Microvasculature in Colon Field Carcinogenesis: Clinical-Biological Implications. The principal investigator is Hemat Roy. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. The overall goal of this project is to develop a rectal probe for minimally intrusive highly accurate risk stratification with the vision of utilizing it for a precision medicine approach to colon cancer screening and also potentially chemoprevention (companion biomarker). We will employ cutting edge biophotonics (ISOCT) and biological approaches combined with large scale human studies to elucidate ...
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  Mentions: National Institutes of Health Boston University
3. Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients
  
  Explore OSA | OSA Publishing Feb 19 2019 Gastroenterology
  
  Tethered capsule endomicroscopy (TCE) is an emerging screening technology that comprehensively obtains microstructural OCT images of the gastrointestinal (GI) tract in unsedated patients. To advance clinical adoption of this imaging technique, it will be important to validate TCE images with co-localized histology, the current diagnostic gold standard. One method for co-localizing OCT images with histology is image-targeted laser marking, which has previously been implemented using a driveshaft-based, balloon OCT catheter, deployed during endoscopy. In this paper, we present a TCE device that scans and targets the imaging beam using a low-cost stepper motor that is integrated inside the capsule. In ...
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  Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University
4. Predict, Resect, Identify and Discard Strategy with Full-field Optical Coherence Tomography: Two Steps Forward, One Step Back
  
  Explore Gastroenterology Feb 17 2019 Gastroenterology
  
  Dear editor, We read with great interest the recently published technique presentation reported by Camus M et al.1 on a rapid on-site evaluation of resected colorectal polyps using full-field optical coherence tomography (FFOCT). We concur that this “predict, resect, identify and discard” paradigm indicated a new way of balancing colonoscopy screening efficacy and pathologic burden as well as shortening the distances among endoscopists, pathologists and patients. While nearly all resected colonic polyps are retrieved for histological analysis in America and Europe, polyp retrieval rate is suboptimal in China due to limited pathologic resources and cost-effectiveness considerations, even in some ...
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5. Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus
  
  Explore Home - ClinicalTrials.gov Feb 5 2019 Gastroenterology , Clinical Trials
  
  The investigators have developed a new technology, termed in-vivo laser capture microdissection (IVLCM), that addresses the limitations of endoscopic biopsy for screening for BE and provides targeted genomic profiling of aberrant tissue for more precise prediction of EAC risk. The device is a tethered capsule endomicroscope (TCE) that implements optical coherence tomography (OCT) to grab 10-mm-resolution, cross-sectional microscopic images of the entire esophagus after the capsule is swallowed. This OCT-based TCE technology is used in unsedated patients to visualize images of BE and dysplastic BE. During the IVLCM procedure, TCE images of abnormal BE tissue are identified in real time ...
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  Mentions: Guillermo J. Tearney National Institutes of Health Massachusetts General Hospital
6. Integrated ultrasound, OCT, PA and/or florescence imaging endoscope for diagnosing cancers in gastrointestinal, respiratory, and urogenital tracts
  
  Explore uspto.gov Jan 22 2019 Gastroenterology , Oncology , Pulmonology , Patents , Probes
  
  A multimodality imaging system including ultrasound, optical coherence tomography (OCT), photoacoustic (PA) imaging, florescence imaging and endoscopic catheter for imaging inside the gastrointestinal tract with real-time automatic image co-registration capability, including: an ultrasound subsystem for imaging; an optical coherence tomography (OCT) subsystem for imaging, a PA microscopy or tomography subsystem for imaging and a florescence imaging subsystem for imaging. An invasive interventional imaging device is included with an instrumentality to take a tissue biopsy from a location visible on the ultrasound subsystem for imaging, on the optical coherence tomography (OCT) subsystem for imaging, photoacoustic (PA) subsystem for imaging and florescence ...
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  Mentions: Zhongping Chen UC Irvine Qifa Zhou
7. Measuring Barrett’s Epithelial Thickness with Volumetric Laser Endomicroscopy as a Biomarker to Guide Treatment
  
  Explore Home - Springer Jan 12 2019 Gastroenterology
  
  Background Radiofrequency ablation (RFA) treatment outcomes vary for unknown reasons. One hypothesis is that variations in Barrett’s epithelial thickness (BET) are associated with reduced RFA efficacy for thicker BET and strictures for thinner BET. Volumetric laser endomicroscopy (VLE) is an imaging modality that acquires high-resolution, depth-resolved images of BE. However, the attenuation of light by tissue and the lack of layering in Barrett’s tissue challenge BET measurements and the study of relationships between thickness and RFA outcomes. We aimed to quantify BET and compared the reliability of standard and contrast-enhanced VLE images. Methods Baseline VLE scans from BE ...
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  Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University
8. Faster 3-D imaging could aid diagnosis of cardiovascular, gastrointestinal disease
  
  Explore PhysOrg.com Dec 3 2018 Gastroenterology , Probes
  
  Researchers have developed a faster way to acquire 3-D endoscopic optical coherence tomography (OCT) images. With further development, the new approach could be useful for early detection and classification of a wide range of diseases. The new method uses computational approaches that create a full 3-D image from incomplete data. In the Optical Society journal Applied Optics , the researchers report that useful 3-D images could be constructed using 40 percent less data than traditional 3-D OCT approaches, which would decrease imaging time by 40 percent. OCT is a biomedical imaging technique that has seen expanding clinical use in recent years ...
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  Mentions: University of Delaware Jigang Wu Shanghai Jiao Tong University
9. Three-dimensional endoscopic OCT using sparse sampling with a miniature magnetic-driven scanning probe
  
  Explore OSA | OSA Publishing Dec 3 2018 Gastroenterology , Probes
  
  We propose to apply sparse sampling and compressive sensing (CS) reconstruction in three-dimensional (3D) endoscopic optical coherence tomography (OCT) to reduce the amount of data required in the imaging process. We used a homemade miniature side-imaging magnetic-driven scanning probe with an outer diameter of 1.4 mm in a 1310 nm swept-source OCT system to acquire two-dimensional (2D) circumferential cross-sectional images of an ex vivo pigeon trachea sample. 3D imaging is then achieved by reconstruction from the multiple 2D images acquired while pulling the sample with a translation stage. Given a total translation distance, we achieved sparse sampling by randomizing ...
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  Mentions: University of Michigan Jigang Wu Shanghai Jiao Tong University
10. Computer-Aided Analysis of Gland-Like Subsurface Hyposcattering Structures in Barrett’s Esophagus Using Optical Coherence Tomography
  
  Explore MDPI Open Access Journals Platform Nov 28 2018 Gastroenterology
  
  (1) Background: Barrett’s esophagus (BE) is a complication of chronic gastroesophageal reflux disease and is a precursor to esophageal adenocarcinoma. The clinical implication of subsurface glandular structures of Barrett’s esophagus is not well understood. Optical coherence tomography (OCT), also known as volumetric laser endomicroscopy (VLE), can assess subsurface glandular structures, which appear as subsurface hyposcattering structures (SHSs). The aim of this study is to develop a computer-aided algorithm and apply it to investigate the characteristics of SHSs in BE using clinical VLE data; (2) Methods: SHSs were identified with an initial detection followed by machine learning. Comprehensive SHS ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Harvard University
11. NinePoint Medical Announces FDA Clearance of an Artificial Intelligence Software Upgrade for the NvisionVLE Imaging System
  
  Explore Optical Coherence Tomography News Nov 5 2018 Gastroenterology , Other Business News
  
  NinePoint Medical, Inc., a transformative medical device company pioneering the use of a real-time imaging platform for gastrointestinal applications, announced today that it has received U.S. Food and Drug Administration (FDA) clearance to market its Intelligent Real-time Image Segmentation™ (IRIS) software upgrade for its flagship product, the NvisionVLE Imaging System. IRIS, an artificial intelligence-based platform for image feature segmentation, is the first tool of its kind approved for use in imaging of esophageal tissue. The NvisionVLE Imaging System allows physicians to perform a Volumetric Laser Endomicroscopy (VLE) procedure that produces real-time, high-resolution cross-sectional images. This system enables gastroenterologists to ...
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  Mentions: FDA NinePoint Medical Eman Namati
12. Super‐achromatic Optical Coherence Tomography Capsule for Ultrahigh‐resolution Imaging of Esophagus
  
  Explore Wiley Online Library Oct 10 2018 Gastroenterology , Probes
  
  Endoscopic optical coherence tomography (OCT) is a noninvasive technology allowing for imaging of tissue microanatomies of luminal organs in real time. Conventional endoscopic OCT operates at 1,300 nm wavelength region with a sub‐optimal axial resolution limited to 8‐20 μm. In this paper we present the first ultrahigh‐resolution tethered OCT capsule operating at 800 nm and offering about 3‐4 fold improvement of axial resolution (plus enhanced imaging contrast). The capsule uses diffractive optics to manage chromatic aberration over a full ~200 nm spectral bandwidth centering around 830 nm, enabling to achieve super‐achromaticity and an axial ...
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  Mentions: Johns Hopkins University Xingde Li
13. Feature Of The Week 10/08/2018: Clinical Utility of Ultrahigh-Speed Endoscopic Optical Coherence Tomography in Gastroenterology
  
  Explore Optical Coherence Tomography News Oct 7 2018 Gastroenterology
  
  Barrett’s esophagus (BE) surveillance is limited by biopsy sampling error. Optical coherence tomography (OCT) enables microscopic resolution, high speed, volumetric imaging and is commercially available as volumetric laser endomicroscopy (VLE, NinePoint Medical). Studies investigated cross-sectional OCT dysplasia features, including a diagnostic algorithm (VLE-DA), however, many VLE studies used ex vivo specimens due to challenges in registering biopsy with OCT. We previously demonstrated ultrahigh-speed endoscopic OCT >10x faster than commercial instruments, enabling depth-resolved en face and cross-sectional imaging. This study investigated volumetric en face and cross-sectional OCT for identifying neoplasia. 74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
14. Advanced Endoluminal Technologies for Barrett's Esophagus: Focus on Optical Coherence Tomography and Confocal Laser Endomicroscopy
  
  Explore Thoracic Surgery Clinics Oct 1 2018 Gastroenterology
  
  High-definition flexible endoscopes allow detailed evaluation of esophageal mucosa and indemnification of the squamocolumnan junction, as well as islands, tongues, or a circumferential extensions of the columnar mucosa into the esophagus.
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15. Assessment of Barrett’s esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography
  
  Explore thieme-connect.de Sep 30 2018 Gastroenterology
  
  Background This study aimed to evaluate the use of ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography (OCT) with micromotor catheters for the in vivo assessment of Barrett’s esophagus and dysplasia. Methods 74 OCT datasets with correlated biopsy/endoscopic mucosal resection histology (49 nondysplastic Barrett’s esophagus [NDBE], 25 neoplasia) were obtained from 14 patients with Barrett’s esophagus and a history of dysplasia and 30 with NDBE. The associations between irregular mucosal patterns on en face OCT, absence of mucosal layering, surface signal > subsurface, and > 5 atypical glands on cross-sectional OCT vs. histology and treatment history were ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
16. Swept-source optical coherence tomography microsystem with an integrated Mirau interferometer and electrothermal micro-scanner
  
  Explore etoponline.org Sep 28 2018 Gastroenterology , Probes
  
  In the rapid evolution of gastrointestinal endomicroscopy, optical coherence tomography (OCT) has found many diverse applications. Until recently, the micro-opto–electro-mechanical systems (MOEMS) technology has been playing a key role in shaping the miniaturization of these components. We report here, to the best of our knowledge, a novel endoscopic microsystem. It is based on a spectrally tuned MOEMS Mirau micro-interferometer integrated with micro-electro-mechanical systems (MEMS) electro-thermal micro-scanner, operating in the regime of swept-source (SS) OCT imaging. This Letter validates our initial proof-of-concept toward the development of such MOEMS probe and the presentation of experimental performances of the resulting SS-OCT microsystem. .
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  Mentions: University of Florida Huikai K. Xie
17. Full-field Optical Coherence Tomography: A New Imaging Modality for rapid on-site Evaluation of resected Polyps during Colonoscopy
  
  Explore Gastroenterology Sep 16 2018 Gastroenterology
  
  No abstract provided.
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  Mentions: LLTech Eugénie Dalimier
18. Predict Recurrence of Barrett's Esophagus After Complete Eradication of Intestinal Metaplasia
  
  Explore Home - ClinicalTrials.gov Sep 13 2018 Gastroenterology , Clinical Trials
  
  Patients with Barrett's Esophagus (BE) undergoing endoscopic therapy through our Barrett's Esophagus Unit will be approached for study enrollment. Patients with no endoscopic evidence of BE will be considered for the study. Surveillance biopsies will be obtained per standard clinical protocol and reviewed to confirm absence of intestinal metaplasia. Patients who have achieved complete eradication of intestinal metaplasia (CRIM) will be enrolled in the study and will undergo the Nvision® Imaging System (VLE). Patients enrolled in the study will undergo clinical follow-up consisting of surveillance endoscopy every 3 months for 1 year. Surveillance endoscopy intervals may be prolonged ...
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  Mentions: NinePoint Medical
19. Assessment and Diagnosis of Human Ovarian and Colorectal Cancer using Optical and Photoacoustic Imaging (Thesis)
  
  Explore Washington University Open Scholarship Sep 11 2018 Gastroenterology , Gynecology , Student Theses
  
  Optical imaging modalities have the advantage of high resolution, label free, rapid, low cost imaging for both in vivo and ex vivo diagnosis of biological tissues. Optical scattering, which is the main contrast of optical coherence tomography (OCT), is related to elastic scattering components, mainly stromal collagen. Tissue elasticity has recently emerged as an important diagnostic parameter associated with tumor development and progression and is also related to the distribution of structural components such as tissue collagen. We have used an optical coherence tomography elastography (OCTE) system for characterizing the differences in the micro-mechanical properties of benign and malignant human ...
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  Mentions: Washington University in St. Louis
20. Feasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study
  
  Explore OSA | OSA Publishing Aug 20 2018 Gastroenterology
  
  Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate between healthy tissue, fibrotic tissue, and residual cancer with a sensitivity and specificity of 79% and 67%, respectively. Hence, OCT has the potential to add to the assessment of a ...
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  Mentions: Johannes F. de Boer Academic Medical Center at the University of Amsterdam VU University Amsterdam
21. Nano-optic endoscope for high-resolution optical coherence tomography in vivo
  
  Explore Nature Publishing Group Jul 30 2018 Gastroenterology , Probes
  
  Acquisition of high-resolution images from within internal organs using endoscopic optical imaging has numerous clinical applications. However, difficulties associated with optical aberrations and the trade-off between transverse resolution and depth of focus significantly limit the scope of applications. Here, we integrate a metalens, with the ability to modify the phase of incident light at subwavelength level, into the design of an endoscopic optical coherence tomography catheter (termed nano-optic endoscope) to achieve near diffraction-limited imaging through negating non-chromatic aberrations. Remarkably, the tailored chromatic dispersion of the metalens in the context of spectral interferometry is utilized to maintain high-resolution imaging beyond the ...
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  Mentions: Massachusetts General Hospital Harvard University Melissa J. Suter
22. NinePoint Medical Appoints Eman Namati, Ph.D., to Chief Executive Officer
  
  Explore Optical Coherence Tomography News Jun 28 2018 Gastroenterology , Other Business News
  
  NinePoint Medical, Inc, a transformative medical device company pioneering the use of Optical Coherence Tomography (OCT) for gastrointestinal applications, is pleased to announce the appointment of Eman Namati, Ph.D., to President and Chief Executive Officer. Dr. Namati succeeds Christopher von Jako, Ph.D., who will continue to serve on the Board of Directors as an independent member. Dr. Namati will assume day-to-day leadership at NinePoint Medical while working in collaboration with Merit Medical Systems Inc. (NASDAQ:MMSI), who now manages the sales distribution and customer service for the NvisionVLE®Imaging System. "With the recent strategic partnership NinePoint entered into ...
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  Mentions: Guillermo J. Tearney Brett E. Bouma Massachusetts General Hospital
23. Optical Coherence Tomography for Barrett Esophagus
  
  Explore gastroenterologyandhepatology.net Jun 26 2018 Gastroenterology
  
  G&H Can you provide a brief overview of optical coherence tomography? VK Optical coherence tomography (OCT) is an advanced imaging technology that was developed in the 1990s. Its application in the endoscopic realm began in the late 1990s. Approximately 5 years ago, a second-generation, advanced OCT technology known as volumetric laser endomicroscopy (VLE; NvisionVLE Imaging System, NinePoint Medical) became available in the US market. Since then, VLE has been the main commercially available OCT-platform product approved by the US Food and Drug Administration for the purpose of advanced endoscopic imaging. The mechanism by which OCT technology works is by ...
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  Mentions: University of Rochester NinePoint Medical
24. Innovative Endoscopies to Be Clinically Used in the Near Future
  
  Explore Home - Springer Jun 23 2018 Gastroenterology , Probes
  
  In contrast to traditional single-lens endoscopies, recently introduced full-spectrum endoscopy (FUSE) scopes include multiple lenses providing a much wider field of view. In many studies, FUSE was shown to be feasible, effective, and safe, and FUSE colonoscopy yielded higher polyp (PDR), adenoma (ADR), and diverticular (DDR) detection rates than did traditional colonoscopy, without therapeutic failure or complications. Moreover, using FUSE gastroscopy, the prevalence of duodenal peri-ampullary diverticula (DPAD) in the general population could be analyzed without using ERCP. In the future, the next generation of modified FUSE system is expected to be useful in direct peroral cholangioscopy and in simultaneous ...
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