1. Articles in category: Gastroenterology

    1-24 of 511 1 2 3 4 ... 20 21 22 »
    1. In vivo endoscopic Doppler optical coherence tomography imaging of the colon

      In vivo endoscopic Doppler optical coherence tomography imaging of the colon

      Background and Objective Colorectal cancer (CRC) remains the second deadliest cancer in the United States. Several screening methods exist; however, detection of small polyps remains a challenge. Optical coherence tomography (OCT) has been demonstrated to be capable of detecting lesions as small as 1 mm in the mouse colon, but detection is based on measuring a doubling of the mucosa thickness. The colon microvasculature may be an attractive biomarker of early tumor development because tumor vessels are characterized by irregular structure and dysfunction. Our goal was to develop an endoscopic method of detecting and segmenting colon vessels using Doppler OCT ...

      Read Full Article
    2. Optical Coherence Tomography: Clinical Applications in Gastrointestinal Endoscopy (Book Chapter)

      Optical Coherence Tomography: Clinical Applications in Gastrointestinal Endoscopy (Book Chapter)

      Optical coherence tomography (OCT) is a high-resolution imaging modality that uses principles of light interferometry. It has achieved clinical application in several other specialties such as ophthalmology and cardiology where its high resolution and deeper penetration into the surface permits much more detailed examination of the mucosa. In the field of gastroenterology, the technology has evolved through several iterations beginning with a focal magnifying imaging technique and evolving into currently a widefield imaging modality that can scan a relatively large area of mucosa with high resolution. OCT has been used to detect dysplasia in Barrett’s esophagus, differentiate between inflammatory ...

      Read Full Article
    3. University of Washington Receives NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 2D Pathology of Pancreas

      University of Washington Receives NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 2D Pathology of Pancreas

      University of Washington Receives a 2016 NIH Grant for $235,226 for Needle Biopsy Preservation and Preparation for Rapid 2D Pathology of Pancreas. The principal investigator is Eric Seibel. The program began in 2014 and ends in 2017. Below is a summary of the proposed work. There are over three million needle biopsies performed every year in the USA, typically for the diagnosis of breast, prostate, thyroid, lung, liver, and pancreatic cancers. Because needle biopsies are less invasive than surgical biopsies, they are much more cost-effective. However, a major limitation for all needle biopsies are that the pathologist or cytologist ...

      Read Full Article
    4. The new kid on the block for advanced imaging in Barrett’s esophagus: a review of volumetric laser endomicroscopy

      The new kid on the block for advanced imaging in Barrett’s esophagus: a review of volumetric laser endomicroscopy

      Advanced imaging techniques used in the management of Barrett’s esophagus include electronic imaging enhancement (e.g. narrow band imaging, flexible spectral imaging color enhancement, and i-Scan), chromoendoscopy, and confocal laser endomicroscopy. Electronic imaging enhancement is used frequently in daily practice, but use of the other advanced technologies is not routine. High-definition white light endoscopy and random four quadrant biopsy remain the standard of care for evaluation of Barrett’s esophagus; this is largely due to the value of advanced imaging technologies not having been validated in large studies or in everyday practice. A new advanced imaging technology called volumetric ...

      Read Full Article
    5. Volumetric laser endomicroscopy can target neoplasia not detected by conventional endoscopic measures in long segment Barrett’s esophagus

      Volumetric laser endomicroscopy can target neoplasia not detected by conventional endoscopic measures in long segment Barrett’s esophagus

      Methods and study aims: The incidence of esophageal cancer is rising despite increased surveillance efforts. Volumetric laser endomicroscopy (VLE) is a new endoscopic imaging tool that can allow for targeted biopsy of neoplasia in Barrett’s esophagus. We report a series of 6 patients with long-segment Barrett’s esophagus ( > 3 cm), who underwent a session of endoscopy with volumetric laser endomicroscopy, after a separate prior session of standard high-definition endoscopy with narrow band imaging (NBI) and random biopsies that did not reveal neoplasia. In all six patients, the first endoscopy was the index endoscopy diagnosing the Barrett’s esophagus. All ...

      Read Full Article
    6. Toward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomography

      Toward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomography

      The mucosal microanatomy of the large intestine is characterized by the presence of crypts of Lieberkühn, which is associated predominantly with goblet cells. Such cellular-level intestinal microstructures undergo morphological changes during the progression of bowel diseases, such as colon cancer or ulcerative colitis. As an indicator of gastric cancers, intestinal metaplasia in the large intestine is characterized by the appearance of goblet cells in gastric epithelium, and therefore, visualization of intestinal microstructure changes in cross-sectional view, particularly in vivo, in a highspeed fashion would assist early disease diagnosis and its treatment. In this paper, we investigated the capability of ...

      Read Full Article
    7. Massachusetts General Hospital Receives a 2016 NIH Grant for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy

      Massachusetts General Hospital Receives a 2016 NIH Grant for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy

      Massachusetts General Hospital Receives a 2016 NIH Grant for $573,805 for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy. The principal investigator is Guillermo Tearney. The program began in $2014 and ends in 2019. Below is a summary of the proposed work. Celiac disease (CD) is an autoimmune response to gluten proteins that affects 3M people in the US and 50M worldwide. These proteins incite an inflammatory reaction that eventually destroys the absorptive villi in the duodenum, resulting in gastrointestinal symptoms, malabsorption, malnutrition, and an increased incidence of other autoimmune diseases, diabetes, and cancer. A definitive diagnosis of CD is ...

      Read Full Article
    8. Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter

      Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter

      We demonstrate a micromotor balloon imaging catheter for ultrahigh speed endoscopic optical coherence tomography (OCT) which provides wide area, circumferential structural and angiographic imaging of the esophagus without contrast agents. Using a 1310 nm MEMS tunable wavelength swept VCSEL light source, the system has a 1.2 MHz A-scan rate and ~8.5 µm axial resolution in tissue. The micromotor balloon catheter enables circumferential imaging of the esophagus at 240 frames per second (fps) with a ~30 µm (FWHM) spot size. Volumetric imaging is achieved by proximal pullback of the micromotor assembly within the balloon at 1.5 mm/sec ...

      Read Full Article
    9. Optical Coherence Tomography Parameters in Morbidly Obese Patients Who Underwent Laparoscopic Sleeve Gastrectomy

      Optical Coherence Tomography Parameters in Morbidly Obese Patients Who Underwent Laparoscopic Sleeve Gastrectomy

      Purpose . To investigate changes in optical coherence tomography parameters in morbidly obese patients who had undergone laparoscopic sleeve gastrectomy (LSG). Methods . A total of 41 eyes of 41 morbidly obese patients (BMI ≥ 40) who had undergone LSG were included in study. The topographic optic disc parameters, central macular thickness (CMT), total macular volume (TMV), and retinal ganglion cell layer (RGCL) were measured by spectral-domain optical coherence tomography (SD-OCT). Subfoveal choroidal thickness (SFCT) was measured by enhanced deep imaging-optical coherence tomography (EDI-OCT). Results . The mean CMT was   μ m,   μ m, and   μ m preoperatively, 3 months postoperatively, and 6 months postoperatively, respectively ( ). The ...

      Read Full Article
    10. Label-Free Imaging of Eosinophilic Esophagitis Mouse Models Using Optical Coherence Tomography

      Label-Free Imaging of Eosinophilic Esophagitis Mouse Models Using Optical Coherence Tomography

      Eosinophilic esophagitis (EoE) is an immune-mediated disorder characterized by esophageal inflammation and related structural changes causing symptoms such as feeding difficulties and food impaction. The pathophysiological mechanisms underlying EoE remain poorly understood. Preclinical studies using mouse models have been critical in comprehending human disease mechanisms and associated pathways. In this chapter, we describe an experimental method using a noninvasive label-free optical imaging technique, optical coherence tomography, to characterize the pathophysiological changes in the esophagus of mice with EoE-like disease ex vivo.

      Read Full Article
    11. NinePoint Medical Announces Completion of Clinical Registry and Publication of Results at DDW 2016

      NinePoint Medical Announces Completion of Clinical Registry and Publication of Results at DDW 2016

      NinePoint Medical, Inc., a transformative medical device company pioneering the use of an advanced imaging platform for gastrointestinal applications, announced today that it has completed the primary phase of its Registry for High Resolution Optical Imaging of the Esophagus Using the NvisionVLE ® Imaging System. Results from the registry’s interim analysis will be presented in 11 scientific abstracts accepted to Digestive Disease Week ® (DDW) 2016, to be held May 21-24 in San Diego, California.

      Read Full Article
    12. Bimodal endoscopic probe combining white-light microscopy and optical coherence tomography

      Bimodal endoscopic probe combining white-light microscopy and optical coherence tomography

      We present a novel bimodal endoscopic imaging probe that can simultaneously provide full-field white-light video microscopy and confocal optical coherence tomography (OCT) depth scans. The two modalities rely on spectrally separated optical paths that run partially in parallel through a micro-optical bench system, which has a cross-section of only 2    mm × 2.76    mm and is realized via standard silicon micromachining techniques. With a numerical aperture of 0.061, the video modality has a resolution and field of view of 9.3 and 1240    μm × 1080    μm , respectively. The resolution is limited by the pixel spacing of the coherent fiber ...

      Read Full Article
    13. Massachusetts Institute of Technology Receives Grant for Optical Biopsy Using Optical Coherence Tomography

      Massachusetts Institute of Technology Receives Grant for Optical Biopsy Using Optical Coherence Tomography

      Massachusetts Institute of Technology Receives a 2016 NIH Grant for $288,576 for Optical Biopsy Using Optical Coherence Tomography. The principal investigator is James Fujimoto. The program began in 1997 and ends in 2019. Below is a summary of the proposed work. This is a multidisciplinary collaboration between investigators at the Massachusetts Institute of Technology and the VA Boston Healthcare System integrating imaging technology research, clinical imaging studies, medical device development and animal imaging studies. Esophageal cancer is a lethal malignancy, with a five-year survival rate of 16%. Barrett's esophagus (BE) and dysplasia are precursors to esophageal adenocarcinoma (EAC ...

      Read Full Article
    14. NinePoint Medical Announces FDA 510(k) Clearance of a Real-Time Targeting Feature for the NvisionVLE® Imaging System and the First Clinical Cases in the U.S.

      NinePoint Medical Announces FDA 510(k) Clearance of a Real-Time Targeting Feature for the NvisionVLE® Imaging System and the First Clinical Cases in the U.S.

      NinePoint Medical, Inc., a transformative medical device company pioneering the use of a real-time imaging platform for gastrointestinal applications, announced today that it has received U.S. Food and Drug Administration (FDA) 510(k) clearance to market its Real-time Targeting™ feature for its flagship product, the NvisionVLE ® Imaging System. In addition, the first procedures with this new system were performed at Beth Israel Deaconess Medical Center in Boston, Massachusetts. The NvisionVLE Imaging System employs proprietary Optical Coherence Tomography (OCT) technology allowing physicians to perform a Volumetric Laser Endomicroscopy (VLE) procedure that produces real-time, high-resolution cross-sectional images. This system enables gastroenterologists ...

      Read Full Article
    15. NinePoint Medical Strengthens Sales Leadership by appointing John Temple as Vice President of Sales

      NinePoint Medical Strengthens Sales Leadership by appointing John Temple as Vice President of Sales

      NinePoint Medical, Inc., a transformative medical device company that is pioneering the clinical use of a real-time imaging platform based upon a proprietary optical coherence tomography (OCT) technology, announced today the appointment of John Temple as Vice President of Sales. Mr. Temple reports directly to NinePoint Medical’s President and CEO, Christopher R. von Jako, Ph.D. “We are delighted to welcome such an accomplished sales executive to the NinePoint Medical team. Not only does John bring tremendous commercial leadership experience, but also in-depth gastroenterology industry knowledge and relationships,” said Dr. von Jako. “John’s exceptional track record will be ...

      Read Full Article
    16. Optical coherence tomography (OCT) prior to peroral endoscopic myotomy (POEM) reduces procedural time and bleeding: a multicenter international collaborative study

      Optical coherence tomography (OCT) prior to peroral endoscopic myotomy (POEM) reduces procedural time and bleeding: a multicenter international collaborative study

      Background Per-oral endoscopic myotomy (POEM) has emerged as an endoscopic treatment of achalasia. There are no pre-procedural imaging modalities to predict the safest and the most efficacious approach. Aim To evaluate the use of optimal coherence tomography (OCT) in providing a pre-procedural esophageal assessment. Methods Patients undergoing POEM from July 2013 to November 2015 were captured in a multicenter, international registry. Patients who underwent OCT pre-POEM (“OCT arm”) were compared to patients without pre-POEM OCT (“control arm”). OCT images were assessed for the degree of vascularity and the thickness of the circular muscular layer, and an approach was determined. Results ...

      Read Full Article
    17. Spectrally encoded miniature endoscopic imaging probe

      Spectrally encoded miniature endoscopic imaging probe

      A spectrally encoded endoscopic probe having high resolution and small diameter comprising at least one flexible optical fiber; an energy source; a grating through which said energy is transmitted such that the energy spectrum is dispersed; a lens for focusing the dispersed energy spectrum onto a sample such that the impingement spot for each wavelength is a separate position on the sample, the wavelength spectrum defining a wavelength encoded axis; means for mechanically scanning the sample with focused energy in a direction perpendicular to the wavelength encoded axis; a means for receiving energy reflected from the sample; and, a means ...

      Read Full Article
    18. Method for identifying malignancies in barrett's esophagus using white light endoscopy

      Method for identifying malignancies in barrett's esophagus using white light endoscopy

      A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume T.sub.HB and oxygenation SO.sub.2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation ...

      Read Full Article
    19. Optical coherence tomography imaging of colonic crypts in a mouse model of colorectal cancer

      Optical coherence tomography imaging of colonic crypts in a mouse model of colorectal cancer

      Aberrant crypt foci (ACF) are abnormal epithelial lesions that precede development of colonic polyps. As the earliest morphological change in the development of colorectal cancer, ACF is a highly studied phenomenon. The most common method of imaging ACF is chromoendoscopy using methylene blue as a contrast agent. Narrow- band imaging is a contrast-agent-free modality for imaging the colonic crypts. Optical coherence tomography (OCT) is an attractive alternative to chromoendoscopy and narrow-band imaging because it can resolve the crypt structure at sufficiently high sampling while simultaneously providing depth-resolved data. We imaged in vivo the distal 15 mm of colon in the ...

      Read Full Article
    20. In vivo endoscopic Doppler optical coherence tomography imaging of mouse colon

      In vivo endoscopic Doppler optical coherence tomography imaging of mouse colon

      Colorectal cancer remains the second deadliest cancer in the United States, despite the high sensitivity and specificity of colonoscopy and sigmoidoscopy. While these standard imaging procedures can accurately detect medium and large polyps, some studies have shown miss rates up to 25% for polyps less than 5 mm in diameter. An imaging modality capable of detecting small lesions could potentially improve patient outcomes. Optical coherence tomography (OCT) has been shown to be a powerful imaging modality for adenoma detection in a mouse model of colorectal cancer. While previous work has focused on analyzing the structural OCT images based on thickening ...

      Read Full Article
    21. Confocal Laser Endomicroscopy and Optical Coherence Tomography for Diagnosing ILD

      Confocal Laser Endomicroscopy and Optical Coherence Tomography for Diagnosing ILD

      Often, assessing a classifying diagnosis in patients with interstitial lung disease provides a diagnostic challenge. Currently HRCT, endoscopic or surgical video assisted thoracoscopic surgery (VATS) assessment including lung biopsies are diagnostic tools for patients with suspected ILD. However, tissue acquisition is associated with morbidity in these patients with an already compromised pulmonary function. In clinical practice this results in the fact that only a minor part of patients with an indication for tissue acquisition are actually undergoing biopsies. The aim of this study is to determine ILD-characteristics on imagign collected with minimal invasive novel optical techniques, to examine whether the ...

      Read Full Article
    22. Tethered capsule detects GI tract disease

      Tethered capsule detects GI tract disease

      The diagnosis and subsequent treatment of many diseases of the upper gastrointestinal tract often call for endoscopic examination. Unfortunately, this is typically expensive, uncomfortable, requires patient sedation and only provides limited information on surface tissues. Subsequent biopsies can provide additional information, but only from limited sample sites. This can be especially problematic when attempting to diagnose diseases with patchy presentations, such as Barrett's oesophagus – in which oesophageal tissues change to resemble those that line the intestine.

      Read Full Article
    23. Advances in upper gastrointestinal endoscopy

      Advances in upper gastrointestinal endoscopy

      The rapidly moving technological advances in gastrointestinal endoscopy have enhanced an endoscopist’s ability to diagnose and treat lesions within the gastrointestinal tract. The improvement in image quality created by the advent of high-definition and magnification endoscopy, alongside image enhancement, produces images of superb quality and detail that empower the endoscopist to identify important lesions that have previously been undetectable. Additionally, we are now seeing technologies emerge, such as optical coherence tomography and confocal laser endomicroscopy, that allow the endoscopist to visualize individual cells on a microscopic level and provide a real time, in vivo histological assessment. Within this article ...

      Read Full Article
    24. Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts

      Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts

      The development of colorectal cancer in the azoxymethane-induced mouse model can be observed by using a miniaturized optical coherence tomography (OCT) imaging system. This system is uniquely capable of tracking disease development over time, allowing for the monitoring of morphological changes in the distal colon due to tumor development and the presence of lymphoid aggregates. By using genetically engineered mouse models deficient in Interleukin 6 (IL-6) and Smad family member 3 (Smad3), the role of inflammation on tumor development and the immune system can be elucidated. Smad3 knockout mice develop inflammatory response, wasting, and colitis associated cancer while deficiency of ...

      Read Full Article
    1-24 of 511 1 2 3 4 ... 20 21 22 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (1 articles) National Institutes of Health
    2. (1 articles) University of Arizona
    3. (1 articles) University of Washington
  4. People in the News

    1. (1 articles) Jennifer K. Barton
    2. (1 articles) Eric J. Seibel