Gastroenterology -Optical Coherence Tomography News

Articles in category: Gastroenterology

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1. Performance characteristics of optical coherence tomography in assessment of Barrett's esophagus and esophageal cancer: systematic review
  
  Explore Journals Sep 17 2017 Gastroenterology
  
  Optical coherence tomography (OCT) can generate high-resolution images of the esophagus that allows cross-sectional visualization of esophageal wall layers. We conducted a systematic review to assess the utility of OCT for diagnosing of esophageal intestinal metaplasia (IM; Barrett's esophagus BE)), dysplasia, cancer and staging of early esophageal cancer. English language human observational studies and clinical trials published in PubMed and Embase were included if they assessed any of the following: (i) in-vivo features and accuracy of OCT at diagnosing esophageal IM, sub-squamous intestinal metaplasia (SSIM), dysplasia, or cancer, and (ii) accuracy of OCT in staging esophageal cancer. Twenty-one of ...
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2. Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source
  
  Explore OSA | OSA Publishing Aug 9 2017 Gastroenterology , Probes
  
  Endoscopic optical coherence tomography (OCT) instruments are mostly side viewing and rely on at least one proximal scan, thus limiting accuracy of volumetric imaging and en face visualization. Previous forward-viewing OCT devices had limited axial scan speeds. We report a forward-viewing fiber scanning 3D-OCT probe with 900 μm field of view and 5 μm transverse resolution, imaging at 1 MHz axial scan rate in the human gastrointestinal tract. The probe is 3.3 mm diameter and 20 mm rigid length, thus enabling passage through the endoscopic channel. The scanner has 1.8 kHz resonant frequency, and each volumetric acquisition takes ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
3. Endomicroscopic optical coherence tomography for cellular resolution imaging of gastrointestinal tracts
  
  Explore Wiley Online Library Aug 8 2017 Gastroenterology
  
  Our ability to detect neoplastic changes in gastrointestinal (GI) tracts is limited by the lack of an endomicroscopic imaging tool that provides cellular-level structural details of GI mucosa over a large tissue area. In this paper, we report a fiber-optic based micro-optical coherence tomography (μOCT) system and demonstrate its capability to acquire cellular-level details of GI tissue through circumferential scanning. The system achieves an axial resolution of 2.48 µm in air and a transverse resolution of 4.8 µm with a depth-of-focus (DOF) of ~150 µm. To mitigate the issue of limited DOF, we used a rigid sheath to ...
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  Mentions: Nanyang Technological University Linbo Liu
4. Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography
  
  Explore SPIE | Journal Jul 10 2017 Gastroenterology
  
  Radiofrequency ablation (RFA) is widely used for the eradication of dysplasia and the treatment of early stage esophageal carcinoma in patients with Barrett’s esophagus (BE). However, there are several factors, such as variation of BE epithelium (EP) thickness among individual patients and varying RFA catheter-tissue contact, which may compromise RFA efficacy. We used a high-speed optical coherence tomography (OCT) system to identify and monitor changes in the esophageal tissue architecture from RFA. Two different OCT imaging/RFA application protocols were performed using an ex vivo swine esophagus model: (1) post-RFA volumetric OCT imaging for quantitative analysis of the coagulum ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Harvard University
5. Cholangioport for optical coherence tomography imaging and photodynamic therapy of the cholangiocarcinoma
  
  Explore Journals Jul 1 2017 Gastroenterology , Oncology
  
  Introduction: Optical Coherence Tomography (OCT) is technology which can be used as criteria efficiency of Photodynamic Therapy (PDT) for cholangiocarcinoma. The prognosis of patients with cholangiocarcinomas is very poor and the first symptom is mechanical jaundice. The percutaneous transhepatic drainage is used in the first stage of treatment. It seemed to be an attractive idea to deliver light directly through the drainage. For doing that it was necessary to determine the possibility of tumor radiation by the semiconductor laser through the catheter wall. Methods: The aim of the first stage of research was to estimate the optimum transmission spectra and ...
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6. Beth Israel Deaconess Medical Center Receives NIH Grant for In Vivo Optical Detection of Dysplasia in Esophagus
  
  Explore Optical Coherence Tomography News Jun 17 2017 Gastroenterology , Funding
  
  Beth Israel Deaconess Medical Center Receives a 2017 NIH Grant for $598,587 for In Vivo Optical Detection of Dysplasia in Esophagus. The principal investigator is Lev Perelman. The program began in 2005 and ends in 2020. Below is a summary of the proposed work. Esophageal adenocarcinoma is the most common esophageal malignancy in Western world and the malignancy that is rising the fastest in the United States – approximately 7% per year over the past 30 years. It has very poor prognosis with less than 15% of patients alive 5 years after diagnosis. Worldwide, 482,300 new esophageal cancer cases ...
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  Mentions: Beth Israel Deaconess Medical Center National Institutes of Health
7. PhD Student Position in integration of a micromachined endomicroscope for OCT imaging in gastroenterology
  
  Explore Optical Coherence Tomography News May 10 2017 Gastroenterology , Jobs & Studentships
  
  The FEMTO-ST Institute (CNRS unit), associated with the Université de Bourgogne et Franche-Comté , announces the opening of a PhD position in integration of a miniature endomicroscope based on MOEMS/microoptical technologies for OCT imaging in gastroenterology. This position can start in October 2017. FEMTO-ST is one of 3 largest research institutes in France in the field of Engineering Sciences, having about 730 employees including more than 150 doctoral students. FEMTO-ST facilities offer the full access to a world-class cleanroom facility (class 10/100). The host team is focusing on MEMS and microoptics. FEMTO-ST received funding from the French government by ...
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  Mentions: FEMTO-ST Institute
8. New Endoscope to Enable Faster, More Accurate Colorectal Cancer Diagnosis
  
  Explore tyndall.ie May 10 2017 Gastroenterology
  
  Researchers at Tyndall National Institute at UCC are taking part in a new European project to develop a low cost, easy to use 3D imaging system that will help enable faster and more accurate diagnosis of colorectal cancers. The Optical Coherence Tomography (OCT) system is being developed by Tyndall as part of the recently launched PICCOLO project, an EU Horizon 2020 funded initiative, bringing together scientists and clinicians across Europe to create an endoscope probe to better diagnose bowel polyps and early colon cancer. Tyndall researcher, Dr. Brendan Roycroft explains: “ Using breakthrough photonics, (the generation, manipulation and utilisation of light ...
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  Mentions: University College Cork
9. Piccolo project develops endoscope for colon cancer diagnosis
  
  Explore optics.org May 9 2017 Gastroenterology , Oncology , Funding
  
  New instrument from Horizon 2020 project will use OCT and MPT for high-resolution imaging. Piccolo project: the European consortium A project funded under the EU Horizon 2020 program aims to develop a novel endoscope for the identification and diagnosis of colorectal cancer, the latest step in the use of optical technologies to tackle one of the world's predominant cancers. Running for three years until December 2019, and involving nine European industrial and research partners led by Spain's Tecnalia Research & Innovation research center, the Piccolo project envisages an advanced endoscope instrument able to deliver high-resolution structural and functional imaging ...
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10. Massachusetts Institute of Technology Receives NIH Grant for Optical Biopsy Using Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News May 9 2017 Gastroenterology , Funding
  
  Massachusetts Institute of Technology Receives a 2017 NIH Grant for $259,717 for Optical Biopsy Using Optical Coherence Tomography. The principal investigator is James Fujimoto. The program began in 1997 and ends in 2019. Below is a summary of the proposed work. This is a multidisciplinary collaboration between investigators at the Massachusetts Institute of Technology and the VA Boston Healthcare System integrating imaging technology research, clinical imaging studies, medical device development and animal imaging studies. Esophageal cancer is a lethal malignancy, with a five-year survival rate of 16%. Barrett's esophagus (BE) and dysplasia are precursors to esophageal adenocarcinoma (EAC ...
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  Mentions: Massachusetts Institute of Technology National Institutes of Health James G. Fujimoto
11. NinePoint Medical to Feature the NvisionVLE® Imaging System with Real-time Targeting™ at DDW 2017; Twenty-four Scientific Abstracts to be Presented
  
  Explore NinePoint Medical May 5 2017 Gastroenterology , Other Business News
  
  – NinePoint Medical, Inc., a transformative medical device company pioneering the use of advanced Optical Coherence Tomography (OCT) for gastrointestinal applications, will be featuring the NvisionVLE® Imaging System with Real-time Targeting™ at Digestive Disease Week® (DDW) 2017, which will be held May 6-9 in Chicago. In addition, results from various studies utilizing this technology in gastroenterology will be presented in 24 scientific abstracts throughout the conference. Random biopsy is the current standard of care for diagnosing esophageal diseases such as Barrett’s esophagus, squamous cell carcinoma, and adenocarcinoma. However, random biopsies assess less than 3% of the esophageal surface1 , leaving more ...
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  Mentions: UC Irvine NinePoint Medical Patrick MacCarthy
12. Imaging system, method and distal attachment for multidirectional field of view endoscopy
  
  Explore uspto.gov Apr 25 2017 Gastroenterology , Patents
  
  An exemplary apparatus for imaging at least one anatomical structure can be provided. For example, the apparatus can include an endoscopic first arrangement, a radiation source second arrangement which provides at least one electro-magnetic radiation, and a third arrangement attached to at least one portion of the endoscopic arrangement. The third arrangement can contain an optical arrangement which, upon impact by the at least one electro-magnetic radiation and based thereon, may transmit a first radiation and reflects a second radiation. The first radiation can impact at least one first portion of the anatomical structure(s), and the second radiation can ...
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  Mentions: Guillermo J. Tearney Brett E. Bouma Massachusetts General Hospital
13. Volumetric laser endomicroscopy in the management of Barrett's esophagus
  
  Explore LWW Online Apr 18 2017 Gastroenterology
  
  Purpose of review: The incidence of esophageal adenocarcinoma is on the rise despite widespread appreciation that the precursor lesion is Barrett's esophagus. Studies have shown that some patients known to have Barrett's esophagus develop cancer despite their enrollment in conventional endoscopic surveillance programs. This highlights the need for advanced endoscopic imaging to help identify early neoplasia and prevent its progression to esophageal cancer. Recently, a wide-field, second-generation optical coherence tomography endoscopic platform called volumetric laser endomicroscopy (VLE) was cleared by the Food and Drug Administration and made commercially available for advanced imaging in Barrett's esophagus. Recent findings ...
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  Mentions: UC Irvine FDA NinePoint Medical
14. Endoscopic optical coherence tomography: technologies and clinical applications [Invited]
  
  Explore OSA | OSA Publishing Apr 12 2017 Gastroenterology
  
  In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forward-viewing probes, along with different scanning mechanisms (proximal-scanning versus distal-scanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic ...
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  Mentions: Johns Hopkins University Massachusetts General Hospital Harvard University
15. Dynamically focused optical coherence tomography for endoscopic applications
  
  Explore aip.scitation.org Apr 12 2017 Gastroenterology
  
  We report a demonstration of a small liquid-filled polymer lens that may be used to dynamically provide scanning depth focus for endoscopic optical coherence tomography (OCT) applications. The focal depth of the lens is controlled by changing the hydraulic pressure within the lens, enabling dynamic focal depth control without the need for articulated parts. The 1 mm diameter lens is shown to have resolving power of 5 μm, and can enable depth scans of 2.5 mm, making it suitable for use with OCT-enabled optical biopsy applications.
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  Mentions: Zhongping Chen UC Irvine Jun Zhang
16. €4m project to speed diagnosis of esophageal cancer
  
  Explore optics.org Mar 14 2017 Gastroenterology , Oncology , Funding
  
  The Institute of Biological and Medical Imaging at Helmholtz Zentrum München , Germany, is heading a research project entitled ”Hybrid optical and optoacoustic endoscope for esophageal tracking” or ESOTRAC . This four-year, €4 million, pan-European project will bring together engineers and physicians to develop a novel hybrid endoscopic instrument for early diagnosis and staging of esophageal cancer. The finished device is expected to reduce the number of unnecessary biopsies and, importantly, facilitate early-disease detection leading to earlier start of therapy, which will improve therapeutic efficacy over late-disease treatment and, ultimately, cost-savings for health care systems. ESOTRAC was awarded the €4 million ...
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17. Easier diagnosis of esophageal cancer
  
  Explore EurekAlert! Mar 6 2017 Gastroenterology
  
  The Institute of Biological and Medical Imaging at Helmholtz Zentrum München is heading the "Hybrid optical and optoacoustic endoscope for esophageal tracking" (ESOTRAC) research project, in which engineers and physicians together develop a novel hybrid endoscopic instrument for early diagnosis and staging of esophageal cancer. The device may reduce the number of unnecessary biopsies and, importantly, facilitate early-disease detection leading to earlier start of therapy, which improves therapeutic efficacy over late-disease treatment and leads to immense cost-savings for the health care system. ESOTRAC has been awarded four million Euros from Horizon 2020, the EU framework program for research and ...
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  Mentions: Medical University of Vienna Vasilis Ntziachristos Technical University of Munich
18. Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett's esophagus: a pilot study (with video)
  
  Explore Elsevier Health Feb 3 2017 Gastroenterology , Oncology
  
  Background and Aims Angiogenesis is associated with neoplastic progression of Barrett’s esophagus (BE). Volumetric optical coherence tomography angiography (OCTA) visualizes subsurface microvasculature without exogenous contrast agents. We investigated the association of OCTA microvascular features with low-grade dysplasia (LGD) and high-grade dysplasia (HGD). Methods Fifty-two patients undergoing BE surveillance or endoscopic eradication therapies for dysplasia were imaged using volumetric OCTA and corresponding histological diagnoses obtained, to yield 97 data sets (non-dysplastic BE (NDBE): N=74; LGD: N=10; HGD: N=13). After evaluating OCTA image quality, 54 datasets (NDBE: N=35; LGD: N=8; HGD: N=11) from 32 patients ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
19. Feasibility of laser marking in Barrett’s esophagus with volumetric laser endomicroscopy: first-in-man pilot study
  
  Explore Gastrointestinal Endoscopy Feb 1 2017 Gastroenterology , Oncology
  
  Background and Aim Volumetric laser endomicroscopy (VLE) provides a circumferential scan of the esophageal wall layers and has potential to improve detection of neoplasia in Barrett’s esophagus (BE). The novel VLE laser marking system enables direct in vivo marking of suspicious areas as identified on VLE. These laser marked areas can subsequently be targeted for biopsies. The aim was to evaluate the visibility and positional accuracy of laser marks (LMs) in different esophageal tissue types on white light endoscopy (WLE) and VLE. Methods Patients with BE with or without neoplasia underwent imaging with VLE. Protocol refinements were practiced in ...
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  Mentions: Academic Medical Center at the University of Amsterdam NinePoint Medical
20. Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter
  
  Explore OSA | OSA Publishing Jan 20 2017 Gastroenterology , Probes
  
  Micro-optical coherence tomography (μOCT) is an advanced imaging technique that acquires a three-dimensional microstructure of biological samples with a high spatial resolution, up to 1 μm, by using a broadband light source and a high numerical aperture (NA) lens. As high NA produces a short depth of focus (DOF), extending the DOF is necessary to obtain a reasonable imaging depth. However, due to the complexity of optics and the limited space, it has been challenging to fabricate endoscopic μOCT, which is essential for clinical translation. Here, we report an endoscopic μOCT probe with an extended DOF by using a binary ...
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  Mentions: Hanyang University Jin Won Kim Hongki Yoo
21. High visibility endoprosthesis and method
  
  Explore uspto.gov Jan 17 2017 Gastroenterology , Patents
  
  An endoprosthesis, a method for imaging an endoprosthesis, a method of making an endoprosthesis involve a polymeric substrate that has been modified to have voids embedded within the substrate. The voids are sized to scatter optical radiation from within the substrate so that an optical coherence tomography (OCT) image can be obtained in which an interior region of the substrate can be easily differentiated from empty space and other structures that surround the endoprosthesis. The voids allow for OCT visualization of the polymeric substrate which may be difficult to visualize by other methods such as fluoroscopy.
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22. Postdoc Researcher Position in integration of a micromachined endomicroscope for OCT imaging in gastroenterology
  
  Explore Optical Coherence Tomography News Jan 3 2017 Gastroenterology , Jobs & Studentships
  
  The FEMTO-ST Institute (CNRS unit), associated with the Université de Bourgogne et Franche-Comté , announces the opening of a Postdoctoral Researcher position in integration of a miniature endomicroscope based on MOEMS/microoptical technologies for OCT imaging in gastroenterology. This position can start in February 2017. FEMTO-ST is one of 3 largest research institutes in France in the field of Engineering Sciences, having about 730 employees including more than 150 doctoral students. FEMTO-ST facilities offer the full access to a world-class cleanroom facility (class 10/100). The host team is focusing on MEMS and microoptics. FEMTO-ST received funding from the French government ...
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  Mentions: FEMTO-ST Institute
23. Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography
  
  Explore OSA | OSA Publishing Dec 27 2016 Gastroenterology
  
  Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is difficult to detect the subsurface lesions. In this research, we investigated the feasibility of a novel multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and molecular imaging. The C57BL/6J-Apc Min /J mice were imaged using OCT and FLOT, and the correlated histopathological diagnosis was obtained. Quantitative structural (scattering coefficient) and molecular (relative enzyme activity ...
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  Mentions: University of Maryland University of Rochester Harvard University
24. Duke University Receives NIH Grant for Advanced A/LCI Systems for Improved Clinical Utility.
  
  Explore Optical Coherence Tomography News Dec 19 2016 Gastroenterology , Funding
  
  Duke University Receives a 2017 NIH Grant for $501,101 for Advanced A/LCI Systems for IMproved linical Utility. The principal investigator is Adam Wax. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. There is a critical unmet need for in vivo detection of dysplasia in patients with Barrett's esophagus (BE), a neoplastic tissue state resulting from chronic acid reflux. BE is associated with an increased risk of esophageal cancer, a disease with a high morbidity rate. Patients with BE undergo periodic endoscopic surveillance with systematic biopsy to search for ...
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  Mentions: National Institutes of Health Duke University Adam Wax
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