1. Articles in category: Gastroenterology

    1-24 of 540 1 2 3 4 ... 21 22 23 »
    1. Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography

      Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography

      Radiofrequency ablation (RFA) is widely used for the eradication of dysplasia and the treatment of early stage esophageal carcinoma in patients with Barrett’s esophagus (BE). However, there are several factors, such as variation of BE epithelium (EP) thickness among individual patients and varying RFA catheter-tissue contact, which may compromise RFA efficacy. We used a high-speed optical coherence tomography (OCT) system to identify and monitor changes in the esophageal tissue architecture from RFA. Two different OCT imaging/RFA application protocols were performed using an ex vivo swine esophagus model: (1) post-RFA volumetric OCT imaging for quantitative analysis of the coagulum ...

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    2. Cholangioport for optical coherence tomography imaging and photodynamic therapy of the cholangiocarcinoma

      Cholangioport for optical coherence tomography imaging and photodynamic therapy of the cholangiocarcinoma

      Introduction: Optical Coherence Tomography (OCT) is technology which can be used as criteria efficiency of Photodynamic Therapy (PDT) for cholangiocarcinoma. The prognosis of patients with cholangiocarcinomas is very poor and the first symptom is mechanical jaundice. The percutaneous transhepatic drainage is used in the first stage of treatment. It seemed to be an attractive idea to deliver light directly through the drainage. For doing that it was necessary to determine the possibility of tumor radiation by the semiconductor laser through the catheter wall. Methods: The aim of the first stage of research was to estimate the optimum transmission spectra and ...

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    3. Beth Israel Deaconess Medical Center Receives NIH Grant for In Vivo Optical Detection of Dysplasia in Esophagus

      Beth Israel Deaconess Medical Center Receives  NIH Grant for In Vivo Optical Detection of Dysplasia in Esophagus

      Beth Israel Deaconess Medical Center Receives a 2017 NIH Grant for $598,587 for In Vivo Optical Detection of Dysplasia in Esophagus. The principal investigator is Lev Perelman. The program began in 2005 and ends in 2020. Below is a summary of the proposed work. Esophageal adenocarcinoma is the most common esophageal malignancy in Western world and the malignancy that is rising the fastest in the United States – approximately 7% per year over the past 30 years. It has very poor prognosis with less than 15% of patients alive 5 years after diagnosis. Worldwide, 482,300 new esophageal cancer cases ...

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    4. PhD Student Position in integration of a micromachined endomicroscope for OCT imaging in gastroenterology

      PhD Student Position in integration of a micromachined endomicroscope for OCT imaging in gastroenterology

      The FEMTO-ST Institute (CNRS unit), associated with the Université de Bourgogne et Franche-Comté , announces the opening of a PhD position in integration of a miniature endomicroscope based on MOEMS/microoptical technologies for OCT imaging in gastroenterology. This position can start in October 2017. FEMTO-ST is one of 3 largest research institutes in France in the field of Engineering Sciences, having about 730 employees including more than 150 doctoral students. FEMTO-ST facilities offer the full access to a world-class cleanroom facility (class 10/100). The host team is focusing on MEMS and microoptics. FEMTO-ST received funding from the French government by ...

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    5. New Endoscope to Enable Faster, More Accurate Colorectal Cancer Diagnosis

      New Endoscope to Enable Faster, More Accurate Colorectal Cancer Diagnosis

      Researchers at Tyndall National Institute at UCC are taking part in a new European project to develop a low cost, easy to use 3D imaging system that will help enable faster and more accurate diagnosis of colorectal cancers. The Optical Coherence Tomography (OCT) system is being developed by Tyndall as part of the recently launched PICCOLO project, an EU Horizon 2020 funded initiative, bringing together scientists and clinicians across Europe to create an endoscope probe to better diagnose bowel polyps and early colon cancer. Tyndall researcher, Dr. Brendan Roycroft explains: “ Using breakthrough photonics, (the generation, manipulation and utilisation of light ...

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    6. Piccolo project develops endoscope for colon cancer diagnosis

      Piccolo project develops endoscope for colon cancer diagnosis

      New instrument from Horizon 2020 project will use OCT and MPT for high-resolution imaging. Piccolo project: the European consortium A project funded under the EU Horizon 2020 program aims to develop a novel endoscope for the identification and diagnosis of colorectal cancer, the latest step in the use of optical technologies to tackle one of the world's predominant cancers. Running for three years until December 2019, and involving nine European industrial and research partners led by Spain's Tecnalia Research & Innovation research center, the Piccolo project envisages an advanced endoscope instrument able to deliver high-resolution structural and functional imaging ...

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    7. Massachusetts Institute of Technology Receives NIH Grant for Optical Biopsy Using Optical Coherence Tomography

      Massachusetts Institute of Technology Receives  NIH Grant for Optical Biopsy Using Optical Coherence Tomography

      Massachusetts Institute of Technology Receives a 2017 NIH Grant for $259,717 for Optical Biopsy Using Optical Coherence Tomography. The principal investigator is James Fujimoto. The program began in 1997 and ends in 2019. Below is a summary of the proposed work. This is a multidisciplinary collaboration between investigators at the Massachusetts Institute of Technology and the VA Boston Healthcare System integrating imaging technology research, clinical imaging studies, medical device development and animal imaging studies. Esophageal cancer is a lethal malignancy, with a five-year survival rate of 16%. Barrett's esophagus (BE) and dysplasia are precursors to esophageal adenocarcinoma (EAC ...

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    8. NinePoint Medical to Feature the NvisionVLE® Imaging System with Real-time Targeting™ at DDW 2017; Twenty-four Scientific Abstracts to be Presented

      NinePoint Medical to Feature the NvisionVLE® Imaging System with Real-time Targeting™ at DDW 2017; Twenty-four Scientific Abstracts to be Presented

      – NinePoint Medical, Inc., a transformative medical device company pioneering the use of advanced Optical Coherence Tomography (OCT) for gastrointestinal applications, will be featuring the NvisionVLE® Imaging System with Real-time Targeting™ at Digestive Disease Week® (DDW) 2017, which will be held May 6-9 in Chicago. In addition, results from various studies utilizing this technology in gastroenterology will be presented in 24 scientific abstracts throughout the conference. Random biopsy is the current standard of care for diagnosing esophageal diseases such as Barrett’s esophagus, squamous cell carcinoma, and adenocarcinoma. However, random biopsies assess less than 3% of the esophageal surface1 , leaving more ...

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    9. Imaging system, method and distal attachment for multidirectional field of view endoscopy

      Imaging system, method and distal attachment for multidirectional field of view endoscopy

      An exemplary apparatus for imaging at least one anatomical structure can be provided. For example, the apparatus can include an endoscopic first arrangement, a radiation source second arrangement which provides at least one electro-magnetic radiation, and a third arrangement attached to at least one portion of the endoscopic arrangement. The third arrangement can contain an optical arrangement which, upon impact by the at least one electro-magnetic radiation and based thereon, may transmit a first radiation and reflects a second radiation. The first radiation can impact at least one first portion of the anatomical structure(s), and the second radiation can ...

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    10. Volumetric laser endomicroscopy in the management of Barrett's esophagus

      Volumetric laser endomicroscopy in the management of Barrett's esophagus

      Purpose of review: The incidence of esophageal adenocarcinoma is on the rise despite widespread appreciation that the precursor lesion is Barrett's esophagus. Studies have shown that some patients known to have Barrett's esophagus develop cancer despite their enrollment in conventional endoscopic surveillance programs. This highlights the need for advanced endoscopic imaging to help identify early neoplasia and prevent its progression to esophageal cancer. Recently, a wide-field, second-generation optical coherence tomography endoscopic platform called volumetric laser endomicroscopy (VLE) was cleared by the Food and Drug Administration and made commercially available for advanced imaging in Barrett's esophagus. Recent findings ...

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    11. Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

      Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

      In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forward-viewing probes, along with different scanning mechanisms (proximal-scanning versus distal-scanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic ...

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    12. Dynamically focused optical coherence tomography for endoscopic applications

      Dynamically focused optical coherence tomography for endoscopic applications

      We report a demonstration of a small liquid-filled polymer lens that may be used to dynamically provide scanning depth focus for endoscopic optical coherence tomography (OCT) applications. The focal depth of the lens is controlled by changing the hydraulic pressure within the lens, enabling dynamic focal depth control without the need for articulated parts. The 1 mm diameter lens is shown to have resolving power of 5 μm, and can enable depth scans of 2.5 mm, making it suitable for use with OCT-enabled optical biopsy applications.

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    13. €4m project to speed diagnosis of esophageal cancer

      €4m project to speed diagnosis of esophageal cancer

      The Institute of Biological and Medical Imaging at Helmholtz Zentrum München , Germany, is heading a research project entitled ”Hybrid optical and optoacoustic endoscope for esophageal tracking” or ESOTRAC . This four-year, €4 million, pan-European project will bring together engineers and physicians to develop a novel hybrid endoscopic instrument for early diagnosis and staging of esophageal cancer. The finished device is expected to reduce the number of unnecessary biopsies and, importantly, facilitate early-disease detection leading to earlier start of therapy, which will improve therapeutic efficacy over late-disease treatment and, ultimately, cost-savings for health care systems. ESOTRAC was awarded the €4 million ...

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    14. Easier diagnosis of esophageal cancer

      Easier diagnosis of esophageal cancer

      The Institute of Biological and Medical Imaging at Helmholtz Zentrum München is heading the "Hybrid optical and optoacoustic endoscope for esophageal tracking" (ESOTRAC) research project, in which engineers and physicians together develop a novel hybrid endoscopic instrument for early diagnosis and staging of esophageal cancer. The device may reduce the number of unnecessary biopsies and, importantly, facilitate early-disease detection leading to earlier start of therapy, which improves therapeutic efficacy over late-disease treatment and leads to immense cost-savings for the health care system. ESOTRAC has been awarded four million Euros from Horizon 2020, the EU framework program for research and ...

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    15. Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett's esophagus: a pilot study (with video)

      Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett's esophagus: a pilot study (with video)

      Background and Aims Angiogenesis is associated with neoplastic progression of Barrett’s esophagus (BE). Volumetric optical coherence tomography angiography (OCTA) visualizes subsurface microvasculature without exogenous contrast agents. We investigated the association of OCTA microvascular features with low-grade dysplasia (LGD) and high-grade dysplasia (HGD). Methods Fifty-two patients undergoing BE surveillance or endoscopic eradication therapies for dysplasia were imaged using volumetric OCTA and corresponding histological diagnoses obtained, to yield 97 data sets (non-dysplastic BE (NDBE): N=74; LGD: N=10; HGD: N=13). After evaluating OCTA image quality, 54 datasets (NDBE: N=35; LGD: N=8; HGD: N=11) from 32 patients ...

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    16. Feasibility of laser marking in Barrett’s esophagus with volumetric laser endomicroscopy: first-in-man pilot study

      Feasibility of laser marking in Barrett’s esophagus with volumetric laser endomicroscopy: first-in-man pilot study

      Background and Aim Volumetric laser endomicroscopy (VLE) provides a circumferential scan of the esophageal wall layers and has potential to improve detection of neoplasia in Barrett’s esophagus (BE). The novel VLE laser marking system enables direct in vivo marking of suspicious areas as identified on VLE. These laser marked areas can subsequently be targeted for biopsies. The aim was to evaluate the visibility and positional accuracy of laser marks (LMs) in different esophageal tissue types on white light endoscopy (WLE) and VLE. Methods Patients with BE with or without neoplasia underwent imaging with VLE. Protocol refinements were practiced in ...

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    17. Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter

      Endoscopic micro-optical coherence tomography with extended depth of focus using a binary phase spatial filter

      Micro-optical coherence tomography (μOCT) is an advanced imaging technique that acquires a three-dimensional microstructure of biological samples with a high spatial resolution, up to 1 μm, by using a broadband light source and a high numerical aperture (NA) lens. As high NA produces a short depth of focus (DOF), extending the DOF is necessary to obtain a reasonable imaging depth. However, due to the complexity of optics and the limited space, it has been challenging to fabricate endoscopic μOCT, which is essential for clinical translation. Here, we report an endoscopic μOCT probe with an extended DOF by using a binary ...

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    18. High visibility endoprosthesis and method

      High visibility endoprosthesis and method

      An endoprosthesis, a method for imaging an endoprosthesis, a method of making an endoprosthesis involve a polymeric substrate that has been modified to have voids embedded within the substrate. The voids are sized to scatter optical radiation from within the substrate so that an optical coherence tomography (OCT) image can be obtained in which an interior region of the substrate can be easily differentiated from empty space and other structures that surround the endoprosthesis. The voids allow for OCT visualization of the polymeric substrate which may be difficult to visualize by other methods such as fluoroscopy.

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    19. Postdoc Researcher Position in integration of a micromachined endomicroscope for OCT imaging in gastroenterology

      Postdoc Researcher Position in integration of a micromachined endomicroscope for OCT imaging in gastroenterology

      The FEMTO-ST Institute (CNRS unit), associated with the Université de Bourgogne et Franche-Comté , announces the opening of a Postdoctoral Researcher position in integration of a miniature endomicroscope based on MOEMS/microoptical technologies for OCT imaging in gastroenterology. This position can start in February 2017. FEMTO-ST is one of 3 largest research institutes in France in the field of Engineering Sciences, having about 730 employees including more than 150 doctoral students. FEMTO-ST facilities offer the full access to a world-class cleanroom facility (class 10/100). The host team is focusing on MEMS and microoptics. FEMTO-ST received funding from the French government ...

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    20. Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

      Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

      Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is difficult to detect the subsurface lesions. In this research, we investigated the feasibility of a novel multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and molecular imaging. The C57BL/6J-Apc Min /J mice were imaged using OCT and FLOT, and the correlated histopathological diagnosis was obtained. Quantitative structural (scattering coefficient) and molecular (relative enzyme activity ...

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    21. Duke University Receives NIH Grant for Advanced A/LCI Systems for Improved Clinical Utility.

      Duke University Receives NIH Grant  for Advanced A/LCI Systems for Improved Clinical Utility.

      Duke University Receives a 2017 NIH Grant for $501,101 for Advanced A/LCI Systems for IMproved linical Utility. The principal investigator is Adam Wax. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. There is a critical unmet need for in vivo detection of dysplasia in patients with Barrett's esophagus (BE), a neoplastic tissue state resulting from chronic acid reflux. BE is associated with an increased risk of esophageal cancer, a disease with a high morbidity rate. Patients with BE undergo periodic endoscopic surveillance with systematic biopsy to search for ...

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    22. Volumetric laser endomicroscopy in Barrett’s esophagus: interobserver agreement for interpretation of Barrett’s esophagus and associated neoplasia among high-frequency users

      Volumetric laser endomicroscopy in Barrett’s esophagus: interobserver agreement for interpretation of Barrett’s esophagus and associated neoplasia among high-frequency users

      Abstract Background and Aims Targeting neoplasia in Barrett’s esophagus (BE) is challenging. Volumetric laser endomicroscopy (VLE) is a new imaging technique that allows for real time cross-sectional microstructure imaging that can detect BE neoplasia. The interobserver agreement among users in practice is unknown. Methods Eight high-volume users of VLE from different academic centers in the United States evaluated 120-stored VLE images blinded to the endoscopic and clinical findings. There were 30 images for each tissue type: gastric cardia, esophageal squamous mucosa, non-neoplastic BE, and neoplastic BE. Each image with BE had corresponding histology confirming the tissue diagnosis. Each normal ...

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    23. Micro-Tech LumiScan Imaging System 510(k) Clearance

      Micro-Tech LumiScan Imaging System 510(k) Clearance

      We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions ...

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      Mentions: FDA Micro-Tech
    24. NinePoint Medical Announces Substantial Hospital Reimbursement Increase for Procedures Using the NvisionVLE Imaging System with Real-time Targeting

      NinePoint Medical Announces Substantial Hospital Reimbursement Increase for Procedures Using the NvisionVLE Imaging System with Real-time Targeting

      NinePoint Medical, Inc., a transformative medical device company pioneering the use of an advanced imaging platform for gastrointestinal applications, announced today that the U.S. Centers for Medicare & Medicaid Services (CMS) has published its 2017 final fee schedule. The annual update includes a material increase to the reimbursement rate for CPT Code 43252 1 ( upper GI endoscopy with optical endomicroscopy ), used for esophageal procedures using the NvisionVLE Imaging System with Real-time Targeting. According to the final 2017 CMS fee schedule, starting January 1, 2017, the reimbursement rate for CPT code 43252 in the hospital out-patient setting increases 131% from $1 ...

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