Category: Gastroenterology

Ninepoint Medical Press Release - NinePoint Medical, Inc., an emerging leader in the development of medical devices for in vivo pathology, today announced that the company will preview its next-generation optical imaging technology, the NvisionVLE™ Imaging System, at Digestive Disease Week 2012 (DDW 2012), being held May 19 to 22 at the San Diego Convention Center in San Diego. NinePoint Medical will provide public demonstrations of the NvisionVLE Imaging System, which is designed to bridge the gap between diagnosis and disease treatment by enabling physicians and pathologists to evaluate high-resolution, volumetric images of organs and tissues in real time. “We are ...

External link. Please review our privacy policy . Aim:  Surgical resection for colorectal cancer involves segmental resection and regional lymphadenectomy. The appropriateness of this "one-size-fits-all" strategy is questioned as bowel cancer screening programmes result in a shift to earlier stage disease. Currently, the nodal status of a colorectal cancer can only be reliably determined by histopathological examination of the resected specimen. New methods of intra-operative staging are required to allow surgical resection to be tailored to the stage of the disease. Method:  A literature search was performed of Pubmed and Embase databases using the terms 'colon' OR 'colorectal' AND 'intra-operative detection ...

Optical coherence tomography (OCT) has demonstrated its potential as a powerful imaging technology due to its cellular or even subcellular resolution (1-10 μm), which is considered suitable for early detection and diagnosis of cancer. For some clinic applications, for example, intravascular or gastrointestinal investigation, full circumferential scanning (FCS) is highly desired. Early research efforts on FCS such as spinning the entire catheter with build-in cables and fibers were capable of scanning at limited speeds with nonlinear motion due to the long cable rotation. Commercially-available micromotors have also been employed to spin mirrors or prisms to achieve FCS. In recent years ...

Barrett's oesophagus is a metaplastic condition with an inherent risk of progression to adenocarcinoma. It is essential to identify dysplastic changes within Barrett's oesophagus in order to individualise surveillance strategies and establish which patients warrant endoscopic treatment. There is a trend towards endoscopic resection of focal high-grade dysplasia followed by whole segment ablation. However, endoscopic identification of dysplastic lesions is unreliable and subjective making targeted therapy extremely difficult. In addition, the current practice of taking random quadrantic biopsies may miss dysplastic disease and intramucosal adenocarcinoma. Several advanced endoscopic imaging techniques have been described and tested in clinical trials ...

Background: Radiofrequency ablation (RFA) is an endoscopic technique used to eradicate Barrett's esophagus (BE). However, such ablation can commonly lead to neosquamous epithelium overlying residual BE glands not visible by conventional endoscopy and may evade detection on random biopsy samples.Objective: To demonstrate the capability of endoscopic 3-dimensional optical coherence tomography (3D-OCT) for the identification and characterization of buried glands before and after RFA therapy.Design: Cross-sectional study.Setting: Single teaching hospital.Patients: Twenty-six male and 1 female white patients with BE undergoing RFA treatment.Interventions: 3D-OCT was performed at the gastroesophageal junction in 18 patients before attaining complete ...

Olympus Corp. , the Japanese camera maker that admitted to a 13-year cover-up of investment losses, said it received capital alliance offers from Sony Corp. ,Fujifilm Holdings Corp.  and Terumo Corp.  Olympus got offers from “more than three” potential partners and may decide as early as next month whether to form a tie-up, President-designate Hiroyuki Sasa said in an interview in Tokyo today. He didn’t name the others. The company plans to release its business plan as early as May, he said at Olympus headquarters.

We study the major factors causing degradation in the lateral resolution of gradient-index-lens-based catheters used for high-resolution optical coherence tomography. Chromatic aberration and astigmatism were taken into account in the propagation of broadband single-mode Gaussian beams through the catheter geometry. It was found that, while chromatic aberration did not preclude achieving high resolution, astigmatism posed a major technical difficulty, because its correction requires a very sensitive adjustment of parameters, especially for catheters with long working distances.

Recent years have witnessed rapid developments of highresolution optical imaging technologies, including (but not limited to) confocal, multispectral, optical coherence tomography, multiphoton fluorescence, second harmonic generation, Raman and/or coherent anti-Stokes Raman spectroscopy, and stimulated Raman scattering microscopy. The highresolution, noninvasive (or minimally invasive), and real-time imaging capability make these technologies well positioned for performing “optical biopsy” in situ and in real time, with a resolution approaching or at that of standard histology. Clinical translation of these technologies, particularly for assessing internal organs, requires miniature probes for delivery, scanning, and collection of the probing/imaging beams. Endomicroscopy is emerging as ...

BOSTON (CBS) – A Cambridge company, NinePoint Medical, has announced the initiation of a clinical trial to evaluate high resolution optical imaging of Barrett’s Esophagus. New England Business Editor, Anthony Silva, spoke with NinePoint President Dr. Charles Carignan. Listen to the report

NinePoint Medical Inc., a developer of medical devices for in vivo pathology, has appointed Patrick MacCarthy vice president of marketing. MacCarthy brings to NinePoint Medical more than 10 years of marketing and sales expertise within the medical device and technology sectors. Most recently, he served with Olympus America Inc. as vice president of marketing, responsible for marketing and strategic planning in the endoscopy division.

The primary objective of this clinical trial is to evaluate the performance of the Nvision Volumetric Laser Endomicroscopy (VLE) system to visualize subsurface tissue in subjects undergoing esophagogastroduodenoscopy (EGD) and to identify work-flow and training implications for introducing this new imaging modality

Trial to Evaluate High-Resolution Optical Imaging of Barrett’s Esophagus;    Company Also Strengthens Leadership Team to Support Commercialization    NinePoint Medical, Inc., an emerging leader in the development of medical devices for in vivo pathology, today announced that the company has initiated a clinical trial to evaluate high-resolution optical imaging of Barrett’s esophagus using its proprietary Nvision VLE Imaging System, which received 510(k) clearance from the U.S. Food and Drug Administration (FDA) earlier this year. NinePoint Medical also announced the expansion of its executive leadership team with the appointment of Patrick MacCarthy to vice president of marketing. The ...

A 30-year-old white man with established Barrett's esophagus (BE) and continued symptoms of chronic severe heartburn, persistent cough, throat irritation, and asthma was referred for surveillance EGD...

Japan's scandal-hit Olympus on Monday forecast a $410 million full-year net loss due to its ailing camera business and tax asset writedowns, but strength in its core endoscope business highlighted its attractiveness to potential investors. The maker of cameras and medical equipment has been considering alliance offers to shore up its finances after a $1.7 billion accounting scandal severely depleted its assets, with Sony, Fujifilm, Terumo and South Korea's Samsung Electronics believed to be among possible suitors.

Computer-aided diagnosis of ophthalmic diseases using optical coherence tomography (OCT) relies on the extraction of thickness and size measures from the OCT images, but such defined layers are usually not observed in emerging OCT applications aimed at "optical biopsy" such as pulmonology or gastroenterology. Mathematical methods such as Principal Component Analysis (PCA) or textural analyses including both spatial textural analysis derived from the two-dimensional discrete Fourier transform (DFT) and statistical texture analysis obtained independently from center-symmetric auto-correlation (CSAC) and spatial grey-level dependency matrices (SGLDM), as well as, quantitative measurements of the attenuation coefficient have been previously proposed to overcome this ...