Gastroenterology -Optical Coherence Tomography News

Articles in category: Gastroenterology

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1. MIT Receives NIH Grant for Optical Biopsy Using Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News Jul 8 2014 Gastroenterology , Funding
  
  Massachusetts Institute of Technology Received a 2014 NIH Grant for $302,576 for Optical Biopsy Using Optical Coherence Tomography. THe principal investigator is James Fujimoto. The program began in 1997 and ends in 2019. Below is a summary of the proposed work. This is a multidisciplinary collaboration between investigators at the Massachusetts Institute of Technology and the VA Boston Healthcare System integrating imaging technology research, clinical imaging studies, medical device development and animal imaging studies. Esophageal cancer is a lethal malignancy, with a five-year survival rate of 16%. Barrett's esophagus (BE) and dysplasia are precursors to esophageal adenocarcinoma (EAC ...
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  Mentions: Massachusetts Institute of Technology National Institutes of Health James G. Fujimoto
2. Forward viewing OCT endomicroscopy (Thesis)
  
  Explore DSpace@MIT Jun 24 2014 Gastroenterology , Probes , Student Theses
  
  A forward viewing fiber optic-based imaging probe device was designed and constructed for use with ultrahigh speed optical coherence tomography in the human gastrointestinal tract. The light source was a MEMS-VCSEL at 1300 nm wavelength running at 300 kHz sweep rate, giving an effective A-line rate of 600 kHz. Data was acquired with a 1.8 GS/s A/D card optically clocked by a maximum fringe frequency of 1 GHz. The optical beam from the probe was scanned by a freely deflecting optical fiber that was mounted proximally on a piezoelectric tubular actuator, which was electrically driven in two ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto
3. Effect of differently sized nanoparticles' accumulation on the optical properties of ex vivo normal and adenomatous human colon tissue with OCT imaging and diffuse reflectance spectra
  
  Explore IOPscience Jun 22 2014 Gastroenterology
  
  Using optical coherence tomography (OCT) and diffuse reflectance spectra, we investigated the dynamics of titanium dioxide (TiO 2 ) nanoparticles, of different sizes, when penetrating and accumulating in human normal colon tissue (NC) and adenomatous colon tissue (AC). The process of nanoparticle penetration and accumulation in biotissue is accompanied by changes in the optical properties of tissue. Continuous OCT monitoring showed that, after application of TiO 2 nanoparticles, the OCT signal intensities of NC and ac both increase with time, and the larger nanoparticles tend to produce a greater signal enhancement in the same type of tissue. The average attenuation coefficient ...
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  Mentions: Sun Yat-Sen University Tsinghua University Fujian Normal University
4. NinePoint Medical Receives 2014 MDEA Silver Medal for NvisionVLE Imaging System
  
  Explore Optical Coherence Tomography News Jun 13 2014 Gastroenterology
  
  NinePoint Medical, Inc., an emerging leader in the development of medical devices for advanced optical imaging, today announced the company was honored with a silver medal at the 2014 Medical Design Excellence Awards (MDEA) for the company’s volumetric optical coherence tomography device, the NvisionVLE Imaging System™. NinePoint and NvisionVLE were among 54 cutting-edge products and companies across 11 medical technology product categories selected as finalists. “Our team has worked diligently over the past four years to bring the NvisionVLE Imaging System to clinicians and patients, and we are pleased that our efforts were recognized by the MDEA with this ...
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  Mentions: Massachusetts General Hospital NinePoint Medical NinePoint Nvision VLE Imaging System
5. Massachusetts General Hospital Receives NIH Grant for Improved Screening and Surveillance in Barrett's Patients
  
  Explore Optical Coherence Tomography News Jun 10 2014 Gastroenterology , Funding
  
  Massachusetts General Hospital received a 2014 NIH grant for $464,015 for Improved Screening and Surveillance in Barrett's Patients. The principal investigator is Gary Tearney. The program began in 2003 and ends in 2015. Below is a summary of the proposed work. Barrett's esophagus (BE) is a metaplastic condition that is associated with chronic gastroesophageal reflux disease (GERD). BE is important because it can progress to esophageal adenocarcinoma, a cancer with a high mortality rate and a rapidly rising incidence. Since identification of BE with dysplasia or early cancer can lead to cure, gastroenterological societies recommend that patients ...
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  Mentions: Guillermo J. Tearney National Institutes of Health Massachusetts General Hospital
6. Gradient index lens based combined two-photon microscopy and optical coherence tomography
  
  Explore opticsinfobase.org May 21 2014 Gastroenterology , Oncology
  
  We report a miniaturized probe-based combined two-photon microscopy (TPM) and optical coherence tomography (OCT) system. This system is to study the colorectal cancer in mouse models by visualizing both cellular and structural information of the colon in 3D with TPM and OCT respectively. The probe consisted of gradient index (GRIN) lenses and a 90° reflecting prism at its distal end for side-viewing, and it was added onto an objective lens-based TPM and OCT system. The probe was 2.2 mm in diameter and 60 mm in length. TPM imaging was performed by raster scanning of the excitation focus at the ...
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  Mentions: Ki Hean Kim Asan Medical Center University of Ulsan
7. Quantitative Diagnosis of Colorectal Polyps by Spectral Domain Optical Coherence Tomography
  
  Explore Hindawi Publishing Corporation May 13 2014 Gastroenterology
  
  The principal aim of this study is to investigate the scattering coefficient of colorectal polyp tissues using an optical coherence tomography (OCT) technique. It combines the existing scattering coefficient model and spectral domain OCT to achieve method of early diagnosis of colorectal polyp in hospitals. Seventeen patients were studied, and a total of 1456 data points were extracted by curve-fitting the OCT signals into a confocal single-backscattering model. The results show that the mean scattering coefficient value for colorectal polyps is 1.91 mm −1 (std: ±0.54 mm −1 ), which is between the values for normal and malignant tissues ...
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  Mentions: Nankai University
8. Endoscopic Optical Coherence Tomography for Clinical Gastroenterology
  
  Explore MDPI Open Access Journals Platform May 10 2014 Gastroenterology
  
  Optical coherence tomography (OCT) is a real-time optical imaging technique that is similar in principle to ultrasonography, but employs light instead of sound waves and allows depth-resolved images with near-microscopic resolution. Endoscopic OCT allows the evaluation of broad-field and subsurface areas and can be used ancillary to standard endoscopy, narrow band imaging, chromoendoscopy, magnification endoscopy, and confocal endomicroscopy. This review article will provide an overview of the clinical utility of endoscopic OCT in the gastrointestinal tract and of recent achievements using state-of-the-art endoscopic 3D-OCT imaging systems.
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Harvard University
9. New Clinical Data using the NvisionVLE™ Imaging System to be presented at Digestive Disease Week® 2014
  
  Explore Optical Coherence Tomography News Apr 30 2014 Gastroenterology
  
  NinePoint Medical, Inc. , an emerging leader in the development of medical devices for advanced optical imaging, today announced that new clinical data, by various investigators using its proprietary NvisionVLE ™ Imaging System, will be presented in a series of 13 oral, video and poster presentations during Digestive Disease Week ® (DDW ® ) 2014. The annual meeting will take place May 3-6 at McCormick Place in Chicago. The schedule for scientific presentations related to advanced optical coherence tomography (OCT) and the NvisionVLE Imaging System at DDW 2014 is provided below. The NvisionVLE Imaging System is indicated for use as an imaging tool in the ...
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  Mentions: Massachusetts General Hospital NinePoint Medical NinePoint Nvision VLE Imaging System
10. New Endoscopic Technology Helps Diagnose Esophageal Cancer Quickly
  
  Explore YouTube Apr 23 2014 Gastroenterology
  
  Esophageal cancer is one of the fastest growing cancer's in America and Pam Sain has been raising money to to raise awareness and get in the fight. After losing her father to esophageal cancer, she began the Taste of Point Orlando event to raise money. The proceeds from those events have gone to purchase new endoscopic technology to help diagnose esophageal cancer more quickly. Something Pam believes could have saved her father. Pam herself was one of the first patients to have an endoscopy with the new device as she is an acid reflux sufferer. To learn more visit ...
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  Mentions: NinePoint Medical NinePoint Nvision VLE Imaging System
11. Optical frequency domain imaging in patients with Barrett's neoplasia: an ex vivo case study with correlated endoscopic and histology views
  
  Explore Gastrointestinal Endoscopy Apr 13 2014 Gastroenterology
  
  This video (, available online at www.giejournal.org) describes the optical frequency domain interferometry (OFDI) imaging technique, which is a U.S. Food and Drug Administration–approved and commercially available second-generation of optical coherence tomography, and its close correlation with endoscopic views and histopathology results in patients with Barrett's esophagus.
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  Mentions: FDA
12. Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomograph
  
  Explore SPIE | Journal Mar 20 2014 Gastroenterology
  
  Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to study colorectal cancer (CRC) and pancreatic cancer (PC) field carcinogenesis. Depth-resolved optical and ultrastructural properties of the mucosa were quantified from histologically normal rectal biopsies from patients with and without colon adenomas ( n = 85 ) as well as from histologically normal peri-ampullary duodenal biopsies from patients with and without PC ( n = 22 ). Changes in the epithelium and stroma in CRC field carcinogenesis were separately quantified. In both compartments, optical and ultra-structural ...
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  Mentions: Northwestern University Vadim Backman Ji Yi
13. NinePoint Medical Completes $34 Million Series B Financing to Expand Commercialization of its Breakthrough NvisionVLE™ Imaging System
  
  Explore Optical Coherence Tomography News Mar 19 2014 Gastroenterology , Funding , Other Business News
  
  NinePoint Medical, Inc. , an emerging leader in the development of medical devices for advanced optical imaging, today announced it has completed a $34 million Series B financing led by Corning Incorporated (NYSE: GLW), along with founding investors Third Rock Ventures and Prospect Venture Partners. The company also announced the addition of three new members to its board of directors: Curt Weinstein from Corning, and independent directors Tom Miller and Mark Stautberg. Proceeds from the financing will support the ongoing commercial launch of the NvisionVLE Imaging System in the U.S., as well as development of the company’s expanded product ...
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  Mentions: Massachusetts General Hospital Boston Scientific Siemens
14. Swept-source common-path optical coherence tomography with a MEMS endoscopic imaging probe
  
  Explore Conference Proceedings Mar 14 2014 Gastroenterology
  
  A MEMS-based common-path endoscopic imaging probe for 3D swept-source optical coherence tomography (SSOCT) has been developed. The common path is achieved by setting the reference plane at the rear surface of the GRIN lens inside the probe. MEMS devices have the advantages of low cost, small size and fast speed, which are suitable for miniaturizing endoscopic probes. The aperture size of the two-axis MEMS mirror employed in this endoscopic probe is 1 mm by 1 mm and the footprint of the MEMS chip is 1.55 mm by 1.7 mm. The MEMS mirror achieves large two dimensional optical scan ...
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  Mentions: University of Florida Huikai K. Xie WiO Technology Limited
15. Korea Research Team Develops Tech for 3D Blood Vessel Endoscope
  
  Explore businesskorea.co.kr Mar 13 2014 Cardiology , Gastroenterology
  
  The Korea Advanced Institute of Science and Technology (KAIST) announced on March 12 that a research team lead by Professor Oh Wang-yuhl from the Department of Mechanical Engineering at KAIST has developed a technology to make a world-class blood vessel endoscope system. The diagnostic imaging technology provides cross-sectional images of the blood vessel walls, up to 3.5 times faster than using the existing blood vessel endoscope system. Therefore, the tech is expected to help in diagnosing and treating cardiovascular diseases. The new optical coherence tomography (OCT) is a method that captures micrometer-resolution, three-dimensional images of blood vessels by inserting ...
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  Mentions: Wang Yuhl Oh Korea Advanced Institute of Science and Technology
16. Combined information from Raman spectroscopy and optical coherence tomography for enhanced diagnostic accuracy in tissue discrimination
  
  Explore Conference Proceedings Mar 8 2014 Gastroenterology , Oncology
  
  Optical spectroscopy and imaging methods have proved to have potential to discriminate between normal and abnormal tissue types through minimally invasive procedures. Raman spectroscopy and Optical Coherence Tomography (OCT) provides chemical and morphological information of tissues respectively, which are complementary to each other. When used individually they might not be able to obtain high enough sensitivity and specificity that is clinically relevant. In this study we combined Raman spectroscopy information with information obtained from OCT to enhance the sensitivity and specificity in discriminating between Colonic Adenocarcinoma from Normal Colon. OCT being an imaging technique, the information from this technique is ...
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  Mentions: Praveen Cheriyan Ashok University of St. Andrews Bavishna B. Praveen
17. Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter
  
  Explore Conference Proceedings Mar 8 2014 Gastroenterology
  
  We developed an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor based imaging catheter, which provided an imaging speed of 600 kHz axial scan rate and 8 μm axial resolution in tissue. The micromotor catheter was 3.2 mm in diameter and could be introduced through the 3.7 mm accessory port of an endoscope. Imaging was performed at 400 frames per second with an 8 μm spot size using a pullback to generate volumetric data over 16 mm with a pixel spacing of 5 μm in ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs
18. Endoscopic Optical Coherence Tomography (OCT): Advances in Gastrointestinal Imaging
  
  Explore Hindawi Publishing Corporation Mar 1 2014 Gastroenterology
  
  In the rapidly evolving field of endoscopic gastrointestinal imaging, Optical Coherence Tomography (OCT) has found many diverse applications. We present the current status of OCT and its practical applications in imaging normal and abnormal mucosa in the esophagus, stomach, small and large intestines, and biliary and pancreatic ducts. We highlight technical aspects and principles of imaging, assess published data, and suggest future directions for OCT-guided evaluation and therapy.
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  Mentions: University of Florida St. Jude Medical
19. Recent Advances in Molecular Imaging of Premalignant Gastrointestinal Lesions and Future Application for Early Detection of Barrett Esophagus
  
  Explore CE :: Clinical Endoscopy Feb 28 2014 Gastroenterology
  
  Recent advances in optical molecular imaging allow identification of morphologic and biochemical changes in tissues associated with gastrointestinal (GI) premalignant lesions earlier and in real-time. This focused review series introduces high-resolution imaging modalities that are being evaluated preclinically and clinically for the detection of early GI cancers, especially Barrett esophagus and esophageal adenocarcinoma. Although narrow band imaging, autofluorescence imaging, and chromoendoscopy are currently applied for this purpose in the clinic, further adoptions of probe-based confocal laser endomicroscopy, high-resolution microendoscopy, optical coherence tomography, and metabolomic imaging, as well as imaging mass spectrometry, will lead to detection at the earliest and will ...
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20. Controversial Data Show RFA Beneficial for LGD in Barrett's, but Accurate Diagnosis Is Key
  
  Explore Gastroenterology & Endoscopy News Feb 24 2014 Gastroenterology , Oncology
  
  Radiofrequency ablation (RFA) in Barrett’s esophagus (BE) patients with low-grade dysplasia (LGD) provides significant protection against progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma, according to the findings of a multicenter, randomized trial presented at the 2013 Digestive Disease Week (DDW) meeting. In fact, the benefit of RFA relative to surveillance alone was so great, that the trial’s safety monitoring committee recommended terminating the trial after an interim analysis. The demonstration that RFA can reduce the risk for progression in patients with LGD has immediate relevance to clinical practice, said the senior author of the study, Jacques J ...
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  Mentions: Boston Scientific University of North Carolina Olympus
21. The Medical College of Wisconsin Receives a NIH Grant for Studying Inhibition of Reflex-Induced Esophageal Adenocarcinoma by Proanthocyanidins
  
  Explore Optical Coherence Tomography News Feb 18 2014 Gastroenterology , Funding
  
  The Medical College of Wisconsin Received a 2014 NIH Grrant for $285,728 for Studying Inhibition of Reflex-Induced Esophageal Adenocarcinoma by Proanthocyanidins. The principal investigator is Laura Kresty. The program began in 2012 and ends in 2017. Below is a summary of the proposed work. Esophageal adenocarcinoma (EAC) rates have increased 500% over the last three decades resulting in EAC being identified as the fastest increasing of all cancer types in the US. Esophageal cancer is an extremely deadly malignancy with 5-year survival rates consistently under 20%. The precise reasons for increasing rates of EAC are an active area of ...
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  Mentions: University of Wisconsin National Institutes of Health
22. Advanced Imaging Technologies for the Detection of Dysplasia and Early Cancer in Barrett Esophagus
  
  Explore KoreaMed Synapse Feb 18 2014 Gastroenterology
  
  Abstract Advanced esophageal adenocarcinomas arising from Barrett esophagus (BE) are tumors with an increasing incidence and poor prognosis. The aim of endoscopic surveillance of BE is to detect dysplasia, particularly high-grade dysplasia and intramucosal cancers that can subsequently be treated endoscopically before progression to invasive cancer with lymph node metastases. Current surveillance practice standards require the collection of random 4-quadrant biopsy specimens over every 1 to 2 cm of BE (Seattle protocol) to detect dysplasia with the assistance of white light endoscopy, in addition to performing targeted biopsies of recognizable lesions. This approach is labor-intensive but should currently be considered ...
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  Mentions: University of Toronto
23. Characterization of eosinophilic esophagitis murine models using optical coherence tomography
  
  Explore opticsinfobase.org Feb 2 2014 Gastroenterology
  
  Pre-clinical studies using murine models are critical for understanding the pathophysiological mechanisms underlying immune-mediated disorders such as Eosinophilic esophagitis (EoE). In this study, an optical coherence tomography (OCT) system capable of providing three-dimensional images with axial and transverse resolutions of 5 µm and 10 µm, respectively, was utilized to obtain esophageal images from a murine model of EoE-like disease ex vivo . Structural changes in the esophagus of wild-type ( Tslpr +/+ ) and mutant ( Tslpr −/− ) mice with EoE-like disease were quantitatively evaluated and food impaction sites in the esophagus of diseased mice were monitored using OCT. Here, the capability of OCT as a ...
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  Mentions: Lehigh University University of Pennsylvania Chao Zhou
24. Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study
  
  Explore Gastrointestinal Endoscopy Jan 26 2014 Gastroenterology
  
  Background Biopsy surveillance protocols for the assessment of Barrett's esophagus can be subject to sampling errors, resulting in diagnostic uncertainty. Optical coherence tomography is a cross-sectional imaging technique that can be used to conduct volumetric laser endomicroscopy (VLE) of the entire distal esophagus. We have developed a biopsy guidance platform that places endoscopically visible marks at VLE-determined biopsy sites. Objective The objective of this study was to demonstrate in human participants the safety and feasibility of VLE-guided biopsy in vivo. Design A pilot feasibility study. Setting Massachusetts General Hospital. Patients A total of 22 participants were enrolled from January ...
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  Mentions: Guillermo J. Tearney Brett E. Bouma Massachusetts General Hospital
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