Gastroenterology -Optical Coherence Tomography News

Articles in category: Gastroenterology

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1. Identification of Volumetric Laser Endomicroscopy features predictive for early neoplasia in Barrett’s esophagus using high-quality histological correlation
  
  Explore Elsevier Health Sep 21 2016 Gastroenterology
  
  Background and aims volumetric laser endomicroscopy (VLE) provides a circumferential scan that enables the visualization of subsurface layers of the esophageal wall at 7 μm resolution. The aims of this study were to identify VLE features ofBarrett’s esophagus (BE) neoplasia and to develop a VLE prediction score. Methods A database of VLE images from endoscopic resection specimens, precisely correlated with histology, from BE patients +/- neoplasia was used. Features potentially predictive for early BE neoplasia were identified by unblinded evaluation of 25 VLE-histology images. In a learning phase, 20 VLE images with or without BE neoplasia were scored by 2 ...
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  Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University
2. Common-path optical coherence tomography using a microelectromechanical-system-based endoscopic probe
  
  Explore OSA | OSA Publishing Aug 23 2016 Gastroenterology , Probes
  
  This paper presents a common-path (CP) swept-source optical coherence tomography (SSOCT) system based on a special endoscopic probe design with an in-line internal reflection as the reference and a two-axis electrothermal microelectromechanical system mirror for image scanning. The rear surface of a gradient reflective index (GRIN) lens inside the probe is set as the reference reflection plane. The length of the GRIN lens is optimized to eliminate the artifacts in SSOCT images successfully. Doppler OCT is also demonstrated based on the CP endoscopic probe. The diameter of the probe is only 2.5 mm, so it can be easily inserted ...
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  Mentions: University of Florida Huikai K. Xie University of Zurich
3. In vivo endoscopic Doppler optical coherence tomography imaging of the colon
  
  Explore Wiley Online Library Aug 22 2016 Gastroenterology , Oncology
  
  Background and Objective Colorectal cancer (CRC) remains the second deadliest cancer in the United States. Several screening methods exist; however, detection of small polyps remains a challenge. Optical coherence tomography (OCT) has been demonstrated to be capable of detecting lesions as small as 1 mm in the mouse colon, but detection is based on measuring a doubling of the mucosa thickness. The colon microvasculature may be an attractive biomarker of early tumor development because tumor vessels are characterized by irregular structure and dysfunction. Our goal was to develop an endoscopic method of detecting and segmenting colon vessels using Doppler OCT ...
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  Mentions: Jennifer K. Barton University of Arizona
4. Optical Coherence Tomography: Clinical Applications in Gastrointestinal Endoscopy (Book Chapter)
  
  Explore Home - Springer Aug 16 2016 Gastroenterology , Textbooks
  
  Optical coherence tomography (OCT) is a high-resolution imaging modality that uses principles of light interferometry. It has achieved clinical application in several other specialties such as ophthalmology and cardiology where its high resolution and deeper penetration into the surface permits much more detailed examination of the mucosa. In the field of gastroenterology, the technology has evolved through several iterations beginning with a focal magnifying imaging technique and evolving into currently a widefield imaging modality that can scan a relatively large area of mucosa with high resolution. OCT has been used to detect dysplasia in Barrett’s esophagus, differentiate between inflammatory ...
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5. University of Washington Receives NIH Grant for Needle Biopsy Preservation and Preparation for Rapid 2D Pathology of Pancreas
  
  Explore Optical Coherence Tomography News Aug 9 2016 Gastroenterology , Funding , Probes
  
  University of Washington Receives a 2016 NIH Grant for $235,226 for Needle Biopsy Preservation and Preparation for Rapid 2D Pathology of Pancreas. The principal investigator is Eric Seibel. The program began in 2014 and ends in 2017. Below is a summary of the proposed work. There are over three million needle biopsies performed every year in the USA, typically for the diagnosis of breast, prostate, thyroid, lung, liver, and pancreatic cancers. Because needle biopsies are less invasive than surgical biopsies, they are much more cost-effective. However, a major limitation for all needle biopsies are that the pathologist or cytologist ...
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  Mentions: National Institutes of Health University of Washington Eric J. Seibel
6. The new kid on the block for advanced imaging in Barrett’s esophagus: a review of volumetric laser endomicroscopy
  
  Explore Therapeutic Advances in Gastroenterology Jul 22 2016 Gastroenterology
  
  Advanced imaging techniques used in the management of Barrett’s esophagus include electronic imaging enhancement (e.g. narrow band imaging, flexible spectral imaging color enhancement, and i-Scan), chromoendoscopy, and confocal laser endomicroscopy. Electronic imaging enhancement is used frequently in daily practice, but use of the other advanced technologies is not routine. High-definition white light endoscopy and random four quadrant biopsy remain the standard of care for evaluation of Barrett’s esophagus; this is largely due to the value of advanced imaging technologies not having been validated in large studies or in everyday practice. A new advanced imaging technology called volumetric ...
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  Mentions: Beth Israel Deaconess Medical Center Harvard University NinePoint Medical
7. Volumetric laser endomicroscopy can target neoplasia not detected by conventional endoscopic measures in long segment Barrett’s esophagus
  
  Explore Thieme Jul 22 2016 Gastroenterology
  
  Methods and study aims: The incidence of esophageal cancer is rising despite increased surveillance efforts. Volumetric laser endomicroscopy (VLE) is a new endoscopic imaging tool that can allow for targeted biopsy of neoplasia in Barrett’s esophagus. We report a series of 6 patients with long-segment Barrett’s esophagus ( > 3 cm), who underwent a session of endoscopy with volumetric laser endomicroscopy, after a separate prior session of standard high-definition endoscopy with narrow band imaging (NBI) and random biopsies that did not reveal neoplasia. In all six patients, the first endoscopy was the index endoscopy diagnosing the Barrett’s esophagus. All ...
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  Mentions: NinePoint Medical
8. Toward High-Speed Imaging of Cellular Structures in Rat Colon Using Micro-optical Coherence Tomography
  
  Explore IEEE Xplore Jul 22 2016 Gastroenterology
  
  The mucosal microanatomy of the large intestine is characterized by the presence of crypts of Lieberkühn, which is associated predominantly with goblet cells. Such cellular-level intestinal microstructures undergo morphological changes during the progression of bowel diseases, such as colon cancer or ulcerative colitis. As an indicator of gastric cancers, intestinal metaplasia in the large intestine is characterized by the appearance of goblet cells in gastric epithelium, and therefore, visualization of intestinal microstructure changes in cross-sectional view, particularly in vivo, in a highspeed fashion would assist early disease diagnosis and its treatment. In this paper, we investigated the capability of ...
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  Mentions: Nanyang Technological University Linbo Liu
9. Massachusetts General Hospital Receives a 2016 NIH Grant for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy
  
  Explore Optical Coherence Tomography News Jul 11 2016 Gastroenterology , Funding
  
  Massachusetts General Hospital Receives a 2016 NIH Grant for $573,805 for Celiac Disease Diagnosis Using Tethered Capsule Endomicroscopy. The principal investigator is Guillermo Tearney. The program began in $2014 and ends in 2019. Below is a summary of the proposed work. Celiac disease (CD) is an autoimmune response to gluten proteins that affects 3M people in the US and 50M worldwide. These proteins incite an inflammatory reaction that eventually destroys the absorptive villi in the duodenum, resulting in gastrointestinal symptoms, malabsorption, malnutrition, and an increased incidence of other autoimmune diseases, diabetes, and cancer. A definitive diagnosis of CD is ...
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  Mentions: Guillermo J. Tearney National Institutes of Health Massachusetts General Hospital
10. Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter
  
  Explore OSA | OSA Publishing Jul 5 2016 Gastroenterology , Probes
  
  We demonstrate a micromotor balloon imaging catheter for ultrahigh speed endoscopic optical coherence tomography (OCT) which provides wide area, circumferential structural and angiographic imaging of the esophagus without contrast agents. Using a 1310 nm MEMS tunable wavelength swept VCSEL light source, the system has a 1.2 MHz A-scan rate and ~8.5 µm axial resolution in tissue. The micromotor balloon catheter enables circumferential imaging of the esophagus at 240 frames per second (fps) with a ~30 µm (FWHM) spot size. Volumetric imaging is achieved by proximal pullback of the micromotor assembly within the balloon at 1.5 mm/sec ...
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  Mentions: Brigham and Women’s Hospital Massachusetts Institute of Technology James G. Fujimoto
11. Optical Coherence Tomography Parameters in Morbidly Obese Patients Who Underwent Laparoscopic Sleeve Gastrectomy
  
  Explore Hindawi Publishing Corporation Jun 21 2016 Gastroenterology , Ophthalmology
  
  Purpose . To investigate changes in optical coherence tomography parameters in morbidly obese patients who had undergone laparoscopic sleeve gastrectomy (LSG). Methods . A total of 41 eyes of 41 morbidly obese patients (BMI ≥ 40) who had undergone LSG were included in study. The topographic optic disc parameters, central macular thickness (CMT), total macular volume (TMV), and retinal ganglion cell layer (RGCL) were measured by spectral-domain optical coherence tomography (SD-OCT). Subfoveal choroidal thickness (SFCT) was measured by enhanced deep imaging-optical coherence tomography (EDI-OCT). Results . The mean CMT was μ m, μ m, and μ m preoperatively, 3 months postoperatively, and 6 months postoperatively, respectively ( ). The ...
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12. Label-Free Imaging of Eosinophilic Esophagitis Mouse Models Using Optical Coherence Tomography
  
  Explore Home - Springer Jun 2 2016 Gastroenterology
  
  Eosinophilic esophagitis (EoE) is an immune-mediated disorder characterized by esophageal inflammation and related structural changes causing symptoms such as feeding difficulties and food impaction. The pathophysiological mechanisms underlying EoE remain poorly understood. Preclinical studies using mouse models have been critical in comprehending human disease mechanisms and associated pathways. In this chapter, we describe an experimental method using a noninvasive label-free optical imaging technique, optical coherence tomography, to characterize the pathophysiological changes in the esophagus of mice with EoE-like disease ex vivo.
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  Mentions: Cornell University Lehigh University Chao Zhou
13. NinePoint Medical Announces Completion of Clinical Registry and Publication of Results at DDW 2016
  
  Explore businesswire.com May 21 2016 Gastroenterology
  
  NinePoint Medical, Inc., a transformative medical device company pioneering the use of an advanced imaging platform for gastrointestinal applications, announced today that it has completed the primary phase of its Registry for High Resolution Optical Imaging of the Esophagus Using the NvisionVLE ® Imaging System. Results from the registry’s interim analysis will be presented in 11 scientific abstracts accepted to Digestive Disease Week ® (DDW) 2016, to be held May 21-24 in San Diego, California.
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  Mentions: NinePoint Medical
14. Bimodal endoscopic probe combining white-light microscopy and optical coherence tomography
  
  Explore OSA | OSA Publishing May 20 2016 Gastroenterology , Microscopy , Probes
  
  We present a novel bimodal endoscopic imaging probe that can simultaneously provide full-field white-light video microscopy and confocal optical coherence tomography (OCT) depth scans. The two modalities rely on spectrally separated optical paths that run partially in parallel through a micro-optical bench system, which has a cross-section of only 2 mm × 2.76 mm and is realized via standard silicon micromachining techniques. With a numerical aperture of 0.061, the video modality has a resolution and field of view of 9.3 and 1240 μm × 1080 μm , respectively. The resolution is limited by the pixel spacing of the coherent fiber ...
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  Mentions: University of Freiburg
15. Massachusetts Institute of Technology Receives Grant for Optical Biopsy Using Optical Coherence Tomography
  
  Explore Optical Coherence Tomography News May 15 2016 Gastroenterology , Funding
  
  Massachusetts Institute of Technology Receives a 2016 NIH Grant for $288,576 for Optical Biopsy Using Optical Coherence Tomography. The principal investigator is James Fujimoto. The program began in 1997 and ends in 2019. Below is a summary of the proposed work. This is a multidisciplinary collaboration between investigators at the Massachusetts Institute of Technology and the VA Boston Healthcare System integrating imaging technology research, clinical imaging studies, medical device development and animal imaging studies. Esophageal cancer is a lethal malignancy, with a five-year survival rate of 16%. Barrett's esophagus (BE) and dysplasia are precursors to esophageal adenocarcinoma (EAC ...
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  Mentions: Massachusetts Institute of Technology National Institutes of Health James G. Fujimoto
16. NinePoint Medical Announces FDA 510(k) Clearance of a Real-Time Targeting Feature for the NvisionVLE® Imaging System and the First Clinical Cases in the U.S.
  
  Explore Optical Coherence Tomography News May 10 2016 Gastroenterology
  
  NinePoint Medical, Inc., a transformative medical device company pioneering the use of a real-time imaging platform for gastrointestinal applications, announced today that it has received U.S. Food and Drug Administration (FDA) 510(k) clearance to market its Real-time Targeting™ feature for its flagship product, the NvisionVLE ® Imaging System. In addition, the first procedures with this new system were performed at Beth Israel Deaconess Medical Center in Boston, Massachusetts. The NvisionVLE Imaging System employs proprietary Optical Coherence Tomography (OCT) technology allowing physicians to perform a Volumetric Laser Endomicroscopy (VLE) procedure that produces real-time, high-resolution cross-sectional images. This system enables gastroenterologists ...
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  Mentions: Beth Israel Deaconess Medical Center Harvard University FDA
17. NinePoint Medical Strengthens Sales Leadership by appointing John Temple as Vice President of Sales
  
  Explore Optical Coherence Tomography News May 3 2016 Gastroenterology , Other Business News
  
  NinePoint Medical, Inc., a transformative medical device company that is pioneering the clinical use of a real-time imaging platform based upon a proprietary optical coherence tomography (OCT) technology, announced today the appointment of John Temple as Vice President of Sales. Mr. Temple reports directly to NinePoint Medical’s President and CEO, Christopher R. von Jako, Ph.D. “We are delighted to welcome such an accomplished sales executive to the NinePoint Medical team. Not only does John bring tremendous commercial leadership experience, but also in-depth gastroenterology industry knowledge and relationships,” said Dr. von Jako. “John’s exceptional track record will be ...
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  Mentions: FDA Olympus NinePoint Medical
18. Optical coherence tomography (OCT) prior to peroral endoscopic myotomy (POEM) reduces procedural time and bleeding: a multicenter international collaborative study
  
  Explore Home - Springer Apr 10 2016 Gastroenterology
  
  Background Per-oral endoscopic myotomy (POEM) has emerged as an endoscopic treatment of achalasia. There are no pre-procedural imaging modalities to predict the safest and the most efficacious approach. Aim To evaluate the use of optimal coherence tomography (OCT) in providing a pre-procedural esophageal assessment. Methods Patients undergoing POEM from July 2013 to November 2015 were captured in a multicenter, international registry. Patients who underwent OCT pre-POEM (“OCT arm”) were compared to patients without pre-POEM OCT (“control arm”). OCT images were assessed for the degree of vascularity and the thickness of the circular muscular layer, and an approach was determined. Results ...
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19. Spectrally encoded miniature endoscopic imaging probe
  
  Explore uspto.gov Mar 29 2016 Gastroenterology , Patents , Probes
  
  A spectrally encoded endoscopic probe having high resolution and small diameter comprising at least one flexible optical fiber; an energy source; a grating through which said energy is transmitted such that the energy spectrum is dispersed; a lens for focusing the dispersed energy spectrum onto a sample such that the impingement spot for each wavelength is a separate position on the sample, the wavelength spectrum defining a wavelength encoded axis; means for mechanically scanning the sample with focused energy in a direction perpendicular to the wavelength encoded axis; a means for receiving energy reflected from the sample; and, a means ...
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  Mentions: Guillermo J. Tearney Brett E. Bouma Massachusetts General Hospital
20. Method for identifying malignancies in barrett's esophagus using white light endoscopy
  
  Explore uspto.gov Mar 29 2016 Gastroenterology , Oncology , Patents
  
  A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume T.sub.HB and oxygenation SO.sub.2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation ...
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  Mentions: Desmond C. Adler Brian C. Wilson
21. Optical coherence tomography imaging of colonic crypts in a mouse model of colorectal cancer
  
  Explore Conference Proceedings Mar 15 2016 Developmental Biology , Gastroenterology
  
  Aberrant crypt foci (ACF) are abnormal epithelial lesions that precede development of colonic polyps. As the earliest morphological change in the development of colorectal cancer, ACF is a highly studied phenomenon. The most common method of imaging ACF is chromoendoscopy using methylene blue as a contrast agent. Narrow- band imaging is a contrast-agent-free modality for imaging the colonic crypts. Optical coherence tomography (OCT) is an attractive alternative to chromoendoscopy and narrow-band imaging because it can resolve the crypt structure at sufficiently high sampling while simultaneously providing depth-resolved data. We imaged in vivo the distal 15 mm of colon in the ...
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  Mentions: Jennifer K. Barton University of Arizona
22. In vivo endoscopic Doppler optical coherence tomography imaging of mouse colon
  
  Explore Conference Proceedings Mar 13 2016 Gastroenterology
  
  Colorectal cancer remains the second deadliest cancer in the United States, despite the high sensitivity and specificity of colonoscopy and sigmoidoscopy. While these standard imaging procedures can accurately detect medium and large polyps, some studies have shown miss rates up to 25% for polyps less than 5 mm in diameter. An imaging modality capable of detecting small lesions could potentially improve patient outcomes. Optical coherence tomography (OCT) has been shown to be a powerful imaging modality for adenoma detection in a mouse model of colorectal cancer. While previous work has focused on analyzing the structural OCT images based on thickening ...
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  Mentions: Jennifer K. Barton University of Arizona
23. Confocal Laser Endomicroscopy and Optical Coherence Tomography for Diagnosing ILD
  
  Explore Home - ClinicalTrials.gov Feb 24 2016 Gastroenterology
  
  Often, assessing a classifying diagnosis in patients with interstitial lung disease provides a diagnostic challenge. Currently HRCT, endoscopic or surgical video assisted thoracoscopic surgery (VATS) assessment including lung biopsies are diagnostic tools for patients with suspected ILD. However, tissue acquisition is associated with morbidity in these patients with an already compromised pulmonary function. In clinical practice this results in the fact that only a minor part of patients with an indication for tissue acquisition are actually undergoing biopsies. The aim of this study is to determine ILD-characteristics on imagign collected with minimal invasive novel optical techniques, to examine whether the ...
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  Mentions: VU University Amsterdam
24. Tethered capsule detects GI tract disease
  
  Explore Medical Physics Feb 23 2016 Gastroenterology
  
  The diagnosis and subsequent treatment of many diseases of the upper gastrointestinal tract often call for endoscopic examination. Unfortunately, this is typically expensive, uncomfortable, requires patient sedation and only provides limited information on surface tissues. Subsequent biopsies can provide additional information, but only from limited sample sites. This can be especially problematic when attempting to diagnose diseases with patchy presentations, such as Barrett's oesophagus – in which oesophageal tissues change to resemble those that line the intestine.
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  Mentions: Guillermo J. Tearney Harvard University
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