Gastroenterology -Optical Coherence Tomography News

Articles in category: Gastroenterology

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1. Covidien Announces Definitive Agreement to Acquire Given Imaging for $860M
  
  Explore Optical Coherence Tomography News Dec 9 2013 Gastroenterology , Acquisition
  
  Covidien Announces Definitive Agreement to Acquire Given Imaging Advances Covidien strategy to more comprehensively address key specialties and procedures globally Adds Given Imaging’s broad suite of minimally invasive gastrointestinal diagnostic and monitoring solutions Accelerates development of world-class gastrointestinal portfolio focused on serving patient from diagnosis to treatment Accretive to earnings per share beginning in fiscal 2015 Covidien plc (NYSE: COV) and Given Imaging Ltd . (Nasdaq: GIVN) today announced a definitive agreement under which Covidien will acquire all of the outstanding shares of Given Imaging for $30.00 per share in cash, for a total of approximately $860 million, net ...
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2. Diagnostic Endoscopy (Textbook)
  
  Explore CRC Press Online Nov 29 2013 Gastroenterology , Textbooks
  
  Combining a professional development course on diagnostic endoscopy from SPIE (the international society advancing light-based research) and the authors’ graduate course on biomedical optics, this work is written for researchers in medical optics and biomedical engineering as well as graduate medical optics students. It uses extensive examples/case studies to familiarize readers with the basics of endoscopic optics, the pros and cons of white light endoscopy and fluorescence endoscopy for diagnostic applications, and various microscopic endoscopy imaging modalities. It covers basic optics, details of design and biomedical uses, as well as microscopic endoscopy, and endoscopic spectroscopy.
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  Mentions: Johns Hopkins University Victor X. D. Yang Beau A. Standish
3. Imaging pancreatobiliary ductal system with optical coherence tomography: A review
  
  Explore World J. Gastroenterology Nov 21 2013 Gastroenterology
  
  An accurate, noninvasive and cost-effective method of in situ tissue evaluation during endoscopy would be highly advantageous for the detection of dysplasia or early cancer and for identifying different disease stages. Optical coherence tomography (OCT) is a noninvasive, high-resolution (1-10 μm) emerging optical imaging method with potential for identifying microscopic subsurface features in the pancreatic and biliary ductal system. Tissue microstructure of pancreaticobiliary ductal system has been successfully imaged by inserting an OCT probe through a standard endoscope operative channel. High-resolution OCT images and the technique’s endoscopic compatibility have allowed for the microstructural diagnostic of the pancreatobiliary diseases. In ...
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  Mentions: Ontario Cancer Institute University of Toronto Victor X. D. Yang
4. British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus
  
  Explore Gut - BMJ Journals Oct 29 2013 Gastroenterology
  
  These guidelines provide a practical and evidence-based resource for the management of patients with Barrett's oesophagus and related early neoplasia. The Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument was followed to provide a methodological strategy for the guideline development. A systematic review of the literature was performed for English language articles published up until December 2012 in order to address controversial issues in Barrett's oesophagus including definition, screening and diagnosis, surveillance, pathological grading for dysplasia, management of dysplasia, and early cancer including training requirements. The rigour and quality of the studies was evaluated using the ...
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  Mentions: University of Manchester University of Cambridge University of Southampton
5. Feature Of The Week 10/27/13: University of St. Andrews Reports on Multi-Modal OCT and Raman Discrimination of Colon Cancer
  
  Explore Optical Coherence Tomography News Oct 27 2013 Gastroenterology
  
  Raman spectroscopy and Optical Coherence Tomography (OCT) are two optical tools that have shown potential to be used for discriminating between normal and abnormal tissue types. Although both of these non-invasive techniques are capable of discriminating between normal and tumour tissues, in many cases, they are unable individually to provide both the high specificity and high sensitivity required for disease diagnosis. Raman spectroscopy and OCT provides complementary information. While Raman spectroscopy provides information about chemical composition of tissues, OCT provides morphological information of tissues. So combining this complementary information might be able to provide higher diagnostic accuracy that is clinically ...
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  Mentions: Praveen Cheriyan Ashok University of St. Andrews Bavishna B. Praveen
6. Image-based noninvasive evaluation of colorectal mucosal injury in sheep after topical application of microbicides
  
  Explore LWW Online Oct 24 2013 Gastroenterology
  
  Background: Successful development of topical rectal microbicides requires preclinical evaluation in suitable large animal models. Our previous studies have demonstrated the benefits of high-resolution optical coherence tomography (OCT) to visualize subclinical microbicide toxicity in the sheep vagina. In the current study, we evaluated the potential application of colonoscopy and OCT to visualize and quantify the effects of topical products on sheep colorectal tissue, as assessed by advanced imaging techniques. Methods: Yearling virginal female sheep were treated rectally with a single 8-mL dose of 0.2% benzalkonium chloride (BZK) solution or phosphate-buffered saline control. Imaging was performed before and 30 minutes ...
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  Mentions: Massoud Motamedi University of Texas Medical Branch
7. Current technology not enough to prevent esophageal adenocarcinoma
  
  Explore Healio.com Oct 21 2013 Gastroenterology
  
  A “disruptive technology” is needed to make significant headway in preventing esophageal adenocarcinoma, a speaker said here. See Also Gatorade/Miralax colonoscopy prep effective, not improved by ... Probiotic did not prevent diarrhea among patients taking ... PPI use may not be linked with loss of bone mineral density ... “What we’re doing now, there’s a very good chance it’s not helping out patients much,” Nicholas J. Shaheen, MD, MPH, said while delivering the Emily Couric Memorial Lecture entitled “Can We Prevent Cancer in Barrett’s Esophagus ?” during the American College of Gastroenterology Annual Scientific Meeting . “You could be looking ...
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  Mentions: Oncoscope Nicholas J. Shaheen
8. Controversial Data Show RF Ablation Beneficial for Low-Grade in Barrett's
  
  Explore General Surgery News Oct 8 2013 Gastroenterology , Oncology
  
  Radiofrequency ablation in Barrett’s esophagus patients with low-grade dysplasia provides significant protection against progression to high-grade dysplasia or esophageal adenocarcinoma, according to the findings of a multicenter, randomized trial presented at the 2013 Digestive Disease Week (DDW) meeting. In fact, the benefit of radiofrequency ablation (RFA) relative to surveillance alone was so great, that the trial’s safety monitoring committee recommended terminating the trial after an interim analysis. The demonstration that RFA can reduce the risk for progression in patients with LGD has immediate relevance to clinical practice, said senior author of the study, Jacques J. Bergman, MD, PhD ...
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  Mentions: Boston Scientific University of North Carolina Olympus
9. MEMS Electrostatic Double T-Shaped Spring Mechanism for Circumferential Scanning
  
  Explore IEEE Xplore Sep 30 2013 Gastroenterology , Probes
  
  A novel microelectromechanical systems (MEMS)-based microscanner is developed with the ultimate goal of integrating it into an endoscopic probe for use in clinical investigations. Microassembly technology is utilized to construct this device, which consists of an electrostatic-based microactuator and a pyramidal polygonal microreflector. A two-stage double T-shaped spring beam system is introduced to the actuator for displacement amplification as well as for motion transfer from the translational movement of the in-plane comb drives to the rotation of the central ring-shaped holder. In the meantime, an eight-slanted-facet-highly-reflective pyramidal polygonal microreflector is developed using high-precision diamond turning and soft lithography technologies ...
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  Mentions: National University of Singapore Guangya Zhou
10. Multi-Modality Endoscopic Imaging for the Detection of Colorectal Cancer (Thesis)
  
  Explore arizona.openrepository.com Sep 24 2013 Gastroenterology , Oncology , Student Theses
  
  Optical coherence tomography (OCT) is an imaging method that is considered the optical analog to ultrasound, using the technique of optical interferometry to construct two-dimensional depth-resolved images of tissue microstructure. With a resolution on the order of 10 μm and a penetration depth of 1-2 mm in highly scattering tissue, fiber optics-coupled OCT is an ideal modality for the inspection of the mouse colon with its miniaturization capabilities. In the present study, the complementary modalities laser-induced fluorescence (LIF), which offers information on the biochemical makeup of the tissue, and surface magnifying chromoendoscopy, which offers high contrast surface visualization, are combined ...
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  Mentions: University of Arizona
11. Enhanced imaging in the GI tract: spectroscopy and optical coherence tomography
  
  Explore Gastrointestinal Endoscopy Sep 20 2013 Gastroenterology
  
  The American Society for Gastrointestinal Endoscopy (ASGE) Technology Committee provides reviews of new or emerging endoscopic technologies that have the potential to have an impact on the practice of GI endoscopy. Evidence-based methodology is used, using a MEDLINE literature search to identify pertinent preclinical and clinical studies on the topic, and a MAUDE (U.S. Food and Drug Administration Center for Devices and Radiological Health) database search to identify the reported adverse events of a given technology. Both are supplemented by accessing the “related articles” feature of PubMed and by scrutinizing pertinent references cited by the identified studies. Controlled clinical ...
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12. Probe alignment and design issues of microelectromechanical system based optical coherence tomography endoscopic imaging
  
  Explore opticsinfobase.org Sep 6 2013 Gastroenterology , Probes
  
  Endoscopic optical coherence tomography (OCT) imaging has been demonstrated using microelectromechanical system (MEMS) technology by several research groups. The focus of this work is to study how the OCT imaging performance is affected by the radius of curvature of MEMS mirrors as well as the optical alignment accuracy inside small imaging probes. The goal of this study is to provide guidance for assembly tolerance and design optimization of OCT endoscopic probes. Gaussian beam propagation is used for theoretical analysis which is confirmed by optical simulation and verified experimentally with a time-domain OCT system as well. It has been found that ...
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  Mentions: University of Florida Huikai K. Xie Jingjing Sun
13. Correction of image distortions in endoscopic optical coherence tomography based on two-axis scanning MEMS mirrors
  
  Explore opticsinfobase.org Sep 6 2013 Gastroenterology , Probes
  
  A two-axis scanning microelectromechanical (MEMS) mirror enables an optical coherence tomography (OCT) system to perform three-dimensional endoscopic imaging due to its fast scan speed and small size. However, the radial scan from the MEMS mirror causes various distortions in OCT images, namely spherical, fan-shaped and keystone distortions. In this paper, a new method is proposed to correct all of three distortions presented in OCT systems based on two-axis MEMS scanning mirrors. The spherical distortion is corrected first by directly manipulating the original spectral interferograms in the phase domain, followed by Fourier transform and three-dimensional geometrical transformation for correcting the other ...
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  Mentions: University of Florida Huikai K. Xie WiO Technology Limited
14. NvisionVLE scans esophageal tissues in real time
  
  Explore optics.org Aug 20 2013 Gastroenterology , Funding
  
  The potential value of optical coherence tomography (OCT) in applications beyond its established presence in ophthalmology has been clear to developers for some time, with significant strides being made in both imaging depth and scan rate. One attractive example is its use in imaging the soft tissues of the gastrointestinal tract and examining pre-cancerous conditions such as Barrett's esophagus, where conventional white light endoscopy suffers from a number of drawbacks. Launched commercially earlier in 2013, the NvisionVLE system from NinePoint Medical allows clinicians to evaluate the esophageal tissue microstructure with OCT during a standard endoscopy procedure. "NinePoint Medical was ...
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  Mentions: Massachusetts General Hospital NinePoint Medical Charles Carignan
15. Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror
  
  Explore SPIE | Journal Aug 15 2013 Gastroenterology , Probes
  
  A microelectromechanical system (MEMS) mirror based endoscopic swept-source optical coherence tomography (SS-OCT) system that can perform three-dimensional (3-D) imaging at high speed is reported. The key component enabling 3-D endoscopic imaging is a two-axis MEMS scanning mirror which has a 0.8 × 0.8 mm 2 mirror plate and a 1.6 × 1.4 mm 2 device footprint. The diameter of the endoscopic probe is only 3.5 mm. The imaging rate of the SS-OCT system is 50 frames / s . OCT images of both human suspicious oral leukoplakia tissue and normal buccal mucosa were taken in vivo and compared. The ...
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  Mentions: University of Florida Huikai K. Xie WiO Technology Limited
16. Unsedated imaging of human upper GI tract using tethered capsule endomicroscopy
  
  Explore Gastroenterology Aug 13 2013 Gastroenterology
  
  Background and Aims In order to overcome limitations of endoscopy, we have integrated a microscopic imaging technology into a tethered capsule that can be swallowed. This new technology, which we term tethered capsule endomicroscopy, provides microscopic information from the entire of esophagus as the pill passes through gastrointestinal (GI) tract. Methods Our tethered capsule endomicroscope implements a second-generation, high-speed form of optical coherence tomography termed optical frequency domain imaging that produces microstructural images with a resolution of 30x30x10μm. The capsule has a dimension of 11x25mm and is connected to 160mm long and 0.8mm thin, flexible tether. Unsedated subjects ...
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  Mentions: Guillermo J. Tearney Massachusetts General Hospital Harvard University
17. University of Arizona Receives NIH Grant for Dual Modality System for Imaging Colon Cancer in Mice
  
  Explore Optical Coherence Tomography News Aug 6 2013 Gastroenterology , Oncology , Funding
  
  University of Arizona Received a 2013 NIH grant for $285,247 for Dual Modality System for Imaging Colon Cancer in Mice. The principal investigator was Jennifer Barton. The program began in 2004 and ends in 2014. Below is a summary of the work. Mouse models of colon cancer are a critical experimental tool for determining the role of specific genes in carcinogenesis, studying tumor initiation and progression, and testing potential chemopreventive and therapeutic compounds. Typically, mouse study outcomes are determined by sacrifice and colon tissue harvesting for procedures such as tumor count, immunohistochemistry, and various assays. Since each animal can ...
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  Mentions: National Institutes of Health Jennifer K. Barton University of Arizona
18. Esophageal Imaging with Next-gen OCT
  
  Explore BioOptics World Jul 24 2013 Gastroenterology
  
  Having already revolutionized ophthalmology, optical coherence tomography (OCT) is about to be introduced to the field of gastroenterology. The approach provides noninvasive and comprehensive depth imaging to improve the detection of esophageal cancer, and hopes to enable screening in addition to assessment. The ability of optical coherence tomography (OCT) to perform non-contact, high-resolution, cross-sectional imaging in real time enabled the technique to revolutionize the field of ophthalmology. 1,2 Although relatively new, OCT has become the gold standard for the diagnosis and treatment of debilitating eye diseases. It is now also being used to image coronary arteries, lungs, skin, bladder ...
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  Mentions: NinePoint Medical NinePoint Nvision VLE Imaging System Patrick MacCarthy
19. Advanced precancerous lesions in the lower oesophageal mucosa: High-grade dysplasia and intramucosal carcinoma in Barrett's oesophagus
  
  Explore bpgastro.com Jul 3 2013 Gastroenterology
  
  Adenocarcinoma developed in Barrett's oesophagus is a tumour with an increasing incidence and still a poor prognosis. The only marker that can be used for surveillance remains dysplasia (intraepithelial neoplasia), especially when it is high-grade, that precedes intramucosal carcinoma. New forms of dysplasia have been described in complement to the classical intestinal type (foveolar dysplasia, basal crypt dysplasia). High-grade dysplasia and intramucosal carcinoma are diagnosed on biopsies taken during endoscopy. Standard endoscopy is now challenged by various techniques that represent recent major technical improvements (chromoendoscopy, virtual chromoendoscopy, optical frequency domain imaging, confocal laser endomicroscopy). In numerous cases, high-grade dysplasia ...
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20. Optical Coherence Tomography in Barrett's Esophagus (Book Chapter)
  
  Explore US Elsevier Health Bookshop Jun 20 2013 Gastroenterology , Textbooks
  
  The incidence of Barrett's-related adenocarcinoma of the esophagus continues to increase at an alarming rate. Studies to date show great promise for optical coherence tomography (OCT) in screening, surveillance, and guiding management of Barrett's esophagus. With continued innovation in rapid, accurate scanning systems, such as volumetric laser endomicroscopy or optical frequency domain imaging, advanced OCT seems likely to have an important impact. The next fes years are likely to see the initiation of large clinical studies that will define the extend and significance of this impact.
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  Mentions: Columbia University
21. The future of colorectal cancer: implications of screening
  
  Explore Gut - BMJ Journals Jun 14 2013 Gastroenterology
  
  In 2003 the countries of the EU agreed to start screening for colorectal cancer (CRC). Currently, several EU countries have implemented a screening programme. As the result of the detection of prevalent cancers with a biannual faecal immunochemical test (FIT) accompanied by an aging population and an increased risk of developing CRC, the incidence of CRC will rise with 35% by 2020 in the Netherlands. 1 , 2 Implementation of a screening programme will lead to a more favourable prognosis at diagnosis through the detection of CRC at an early, asymptomatic stage. Of all cancer s detected with a single guaiac ...
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22. Optical Coherence Tomography in Barrett's Esophagus
  
  Explore giendo.theclinics.com Jun 3 2013 Gastroenterology
  
  The incidence of Barrett’s-related adenocarcinoma of the esophagus continues to increase at an alarming rate. Studies to date show great promise for optical coherence tomography (OCT) in screening, surveillance, and guiding management of Barrett’s esophagus. With continued innovation in rapid, accurate scanning systems, such as volumetric laser endomicroscopy or optical frequency domain imaging, advanced OCT seems likely to have an important impact. The next few years are likely to see the initiation of large clinical studies that will define the extent and significance of this impact.
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  Mentions: Columbia University
23. Lens-free endoscopy probe for optical coherence tomography
  
  Explore opticsinfobase.org May 31 2013 Gastroenterology , Probes
  
  We present an ultrathin fiber-optic endoscopy probe for optical coherence tomography (OCT), which is made of a series of fused optical fibers instead of the conventional scheme based on an objective lens. The large-core fiber with a core diameter of 20 μm was utilized for the probe, while a single-mode fiber of core diameter 8.2 μm mainly delivered the OCT light. Those fibers were spliced with a bridge fiber of an intermediate core size. The guided light was stepwise converted to a beam of a large mode-field diameter to be radiated with a larger depth of focus. We obtained ...
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  Mentions: Zhongping Chen UC Irvine Chang-Seok Kim
24. NinePoint Medical launches esophageal imaging system
  
  Explore bizjournals May 16 2013 Gastroenterology , Other Business News
  
  Cambridge medical device company NinePoint Medical Inc. on Thursday launched its lead product in the U.S., an imaging system that makes it easier to examine and detect diseases of the esophagus. NinePoint’s proprietary NvisionVLE Imaging System was granted 510(k) clearance in December 2011 to be used as an imaging tool in the evaluation of human tissue microstructure. Last month, it received additional clearance to to include imaging of esophageal tissue microstructure. In June 2012, the device received European CE mark approval .
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  Mentions: Massachusetts General Hospital NinePoint Medical
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