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Organizations in the News
(16 articles) Harvard University
(14 articles) Massachusetts General Hospital
(14 articles) Massachusetts Institute of Technology
(10 articles) University of Florida
(9 articles) University of Arizona
(8 articles) University of Western Australia
(7 articles) Azienda Ospedaliera San Paolo
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Progress toward inexpensive endoscopic high-resolution common-path OCT
Explore Article SPIE Digital Library (Feb 24 2010) Endoscopy , Probes
Presented in this work is our effort to develop a simple, inexpensive high resolution fiber-optic Optical Coherence Tomography. The approach is based on common-path Fourier Domain OCT (CP-FDOCT), which can lead to applications for both microsurgical tool control and high-resolution endoscopic imaging. The system utilizes a combination of standard fiber optic components and novel signal processing techniques in order to achieve high axial resolution and to simplify the system. High axial resolution is achieved by implementing the Enhanced Lee filter to reduce speckle noise in the OCT image and Richardson-Lucy deconvolution algorithm afterwards to suppress sidelobes induced by the system's ...
Comment on Article Mentions: Jin U. Kang Johns Hopkins University
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Endoscopic 3D-OCT reveals buried glands following radiofrequency ablation of Barrett's esophagus
Explore Article SPIE Digital Library (Feb 24 2010) Endoscopy
Barrett's esophagus (BE) with high-grade dysplasia is generally treated by endoscopic mucosal resection or esophagectomy. Radiofrequency ablation (RFA) is a recent treatment that allows broad and superficial ablation for BE. Endoscopic three-dimensional optical coherence tomography (3D-OCT) is a volumetric imaging technique that is uniquely suited for follow-up surveillance of RFA treatment. 3D-OCT uses a thin fiberoptic imaging catheter placed down the working channel of a conventional endoscope. 3D-OCT enables en face and cross-sectional evaluation of the esophagus for detection of residual BE, neo-squamous mucosa, or buried BE glands. Patients who had undergone RFA treatment with the BARRX HALO90 system were ...
Comment on Article Mentions: LightLab Imaging Massachusetts Institute of Technology Joseph M. Schmitt
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A dual modality fluorescence confocal and optical coherence tomography microendoscope
Explore Article SPIE Digital Library (Feb 24 2010) Endoscopy , Microscopy , Oncology
We demonstrate the implementation of a Fourier domain optical coherence tomography (OCT) imaging system incorporated into the optical train of a fluorescence confocal microendoscope. The slit-scanning confocal system has been presented previously and achieves 3µm lateral resolution and 25µm axial resolution over a field of view of 430µm. Its multi-spectral mode of operation captures images with 6nm average spectral resolution. To incorporate OCT imaging, a common-path interferometer is made with a super luminescent diode and a reference coverslip located at the distal end of the fiber bundle catheter. The infrared diode spectral width allows a theoretical OCT axial resolution of ...
Comment on Article Mentions: University of Arizona
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Optical micro-endoscopes for 3D in-vivo imaging
Explore Article Home: SPIE.org (Feb 22 2010) Endoscopy , Probes
Electrothermal micromirrors and a flexible printed circuit board permit fast, small optical coherence tomography of internal organs. Optical coherence tomography (OCT) is a medical optical imaging technique that can achieve high-resolution 3D images (1-15μm)1 by detecting infrared light scattered by body tissue. It has an imaging depth range of about 3mm in highly-scattered tissue and has already been widely used for external imaging, e.g., for eye diseases and skin cancer diagnosis. It would be useful to apply OCT to internal imaging, since about 85% of all cancers originate from the surface layers of internal organs. As these layers are within ...
Comment on Article Mentions: Lei Wu Huikai Xie University of Florida
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High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe
Explore Article opticsinfobase.org (Feb 17 2010) Endoscopy , Microscopy , Probes
ical coherence microscopy (OCM) is a promising technique for high resolution cellular imaging in human tissues. An OCM system for high-speed en face cellular resolution imaging was developed at 1060 nm wavelength at frame rates up to 5 Hz with resolutions of < 4 µm axial and < 2 µm transverse. The system utilized a novel polarization compensation method to combat wavelength dependent source polarization and achieve broadband electro-optic phase modulation compatible with ultrahigh axial resolution. In addition, the system incorporated an auto-focusing feature that enables precise, near real-time alignment of the confocal and coherence gates in tissue, allowing user-friendly ...
Comment on Article Mentions: James G. Fujimoto Shu-Wei Huang Aaron D. Aguirre
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In vivo 3D and Doppler OCT imaging using electrothermal MEMS scanning mirrors
Explore Article SPIE Digital Library (Feb 16 2010) Endoscopy , Oncology , Probes
Most cancers occur inside human body, so endoscopic high-resolution imaging modalities are required for early cancer detection and surgical removal. This paper reports in vivo endoscopic 3D imaging based on optical coherence tomography (OCT). Endoscopic imaging is enabled by integrating rapid-scanning MEMS mirror into a miniature imaging probe. The MEMS mirror has an aperture size of 1 mm by 1 mm and a chip size of 2 mm by 2 mm. The optical scan angle exceeds ±25 V at 6 Vdc, and thus large, constant-velocity, linear scan can be realized. The outer diameter of the probe is only 5 mm. ...
Comment on Article Mentions: Lei Wu Huikai Xie Shuguang Guo
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Biased assessment of 3D optical coherence tomography in a single post-radiofrequency ablation patient without histological correlation
Explore Article thieme-connect.de (Feb 9 2010) Endoscopy
case report entitled “Three-dimensional optical coherence tomography of Barrett’s esophagus and buried glands beneath neosquamous epithelium following radiofrequency ablation,” was recently published by Adler et al. in Endoscopy [1]. Based on the title and abstract, we fully expected the authors to present evidence showing that three-dimensional optical coherence tomography (3D-OCT) was able to detect buried Barrett’s after radiofrequency ablation (RFA) that was otherwise not detectable with conventional methods. Unfortunately, the authors report a single ablation-naïve case where it seems that buried glands were detected on biopsy yet not specifically detected with 3D-OCT or explicitly described in their findings, followed by ...Comment on Article Mentions: Academic Medical Center at the University of Amsterdam
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Method for endoluminal imaging with movement correction
Explore Article PatFT » Page 1 of 1 (Feb 2 2010) Endoscopy , Patents
The present invention relates to a method for imaging using an image-generating, endoluminal instrument (1) by means of which a sequence of 2D image data of a hollow channel (2), in particular a vessel, of an object under investigation is recorded, wherein the images are recorded in a known temporal relation to a periodic movement of the object under investigation and spatial coordinates of the image are captured by means of a position sensor during each recording of an image (5) and stored as position data (9, 10) together with the 2D image data of the image (5). The method ...Comment on Article Mentions: Siemens
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Optical coherence tomography in Barrett's esophagus: the road to clinical utility
Explore Article Gastrointestinal Endoscopy (Jan 31 2010) Endoscopy
Will gastroenterologists ever push the “OCT button” on their endoscopes to obtain clinically actionable images? Nine years ago in this journal, optical coherence tomography (OCT) was described as ‘‘the most noteworthy advance in diagnostic imaging of the GI tract’’ since the development of endoscopic US.1 In the time since, OCT has continued to develop, with a steady stream of articles describing applications and improvements. However, use of OCTremains largely investigational, and most studies involve technology not suitable for endoscopic delivery. Will gastroenterologists ever push the ‘‘OCT button’’ on their endoscopes to obtain clinically actionable images? What is the state of ...
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High-resolution OCT explores the gut
Explore Article optics.org (Jan 25 2010) Endoscopy , Oncology , Probes
Fourier domain detection has greatly improved the speed and resolution of optical coherence tomography (OCT), opening up the possibility of in vivo clinical imaging. A team of Toronto-based researchers has now shown how this technology could be applied inside the gastrointestinal tract, a technique that could replace invasive biopsies when looking for early signs of cancer (Phys. Med. Biol. 55 615). The miniaturized OCT imager is the result of collaboration between the University of Toronto (Toronto, CA), Princess Margaret Hospital (Toronto, CA) and Michelson Diagnostics in the UK. The core technology is a multi-beam Fourier domain OCT system that uses ...
Comment on Article Mentions: Michelson Diagnostics Beau A. Standish University of Toronto
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In vivo endoscopic multi-beam optical coherence tomography
Explore Article Institute of Physics (Jan 12 2010) Endoscopy
multichannel optical coherence tomography (multi-beam OCT) system and an in vivo endoscopic imaging probe were developed using a swept-source OCT system. The distal optics were micro-machined to produce a high numerical aperture, multi-focus fibre optic array. This combination resulted in a transverse design resolution of <10 µm full width half maximum (FWHM) throughout the entire imaging range, while also increasing the signal intensity within the focus of the individual channels. The system was used in a pre-clinical rabbit study to acquire in vivo structural images of the colon and ex vivo images of the oesophagus and trachea. A good correlation ...
Comment on Article Mentions: Sunnybrook Health Sciences Centre Ryerson University I. Alex Vitkin
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Intraperitoneal Virtual Biopsy by Fibered Optical Coherence Tomography (OCT) at Natural Orifice Transluminal Endoscopic Surgery (NOTES)
Explore Article SpringerLink Home (Dec 9 2009) Endoscopy
ntroduction Fibered optical coherence tomography (OCT) in conjunction with natural orifice transluminal endoscopic surgery (NOTES) could provide a facility for rapid, in situ pathological diagnosis of intraperitoneal tissues in a truly minimally invasive fashion. Materials and Methods A large porcine model was established to test this hypothesis. A standard double channel gastroscope (Olympus) was used to achieve a transgastric access to the peritoneum and initiate the pneumoperitoneum. Magnetic retraction was used to display the sigmoid colon along with its mesentery. A commercially available fibered OCT probe (NIRIS system, Imalux) was inserted via a working channel of the gastroscope and used ...Comment on Article Mentions: Imalux Imalux Niris Olympus
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New Endoscope Sees What Lies Beneath: An infrared-based endoscope scans tissue below the surface.
Explore Article Technology Review (Dec 3 2009) Endoscopy , Oncology , Probes
An endoscope equipped with an infrared laser and a tiny mirror might one day help physicians diagnose early signs of cancer and other diseases and aid in surgery. A researcher at the University of Florida has designed a prototype device that captures images up to two millimeters beneath the surface of tissues, providing high-resolution, three-dimensional images at video-rate speeds. In typical endoscopy, doctors thread a long, thin, camera-equipped fiber through a patient's airway or gastrointestinal tract to search out abnormalities. The images, displayed on a monitor in real time, can reveal signs of infection, internal bleeding, ulcers, and tumors on ...
Comment on Article Mentions: Huikai Xie University of Florida Brigham and Women’s Hospital
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New Technologies for Imaging of Barrett’s Esophagus
Explore Article SpringerLink Home (Dec 1 2009) Endoscopy , Oncology
Several important endoscopic imaging modalities have recently been approved for use and are commercially available. This chapter briefly reviews these developments and the implication for patients with Barrett’s esophagus, especially advanced dysplasia and mucosal carcinoma. Important developments in biophotonics have been moving from the experiment laboratory to the gastrointestinal endoscopy unit. Narrow band imaging, auto-fluorescence, confocal fluorescent microscopy, spectroscopy and optical coherence tomography are reviewed. Unresolved issues for most of these technologies include regulatory approval, commercial availability and demonstration of clinical utility. This chapter reviews recent developments in endoscopy-based imaging modalities in patients with Barrett’s esophagus.
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3D endoscopic optical coherence tomography based on rapid-scanning MEMS mirrors
Explore Article SPIE Digital Library (Nov 25 2009) Endoscopy , Oncology , Probes
The paper reports 3D in vivo endoscopic imaging enabled by integrating rapid-scanning MEMS mirrors into an optical coherence tomography (OCT) imaging probe. OCT provides high-resolution cross-sectional information suitable for in vivo noninvasive early cancer diagnosis. However, conventional OCT systems are bulky and slow, and thus are difficult to apply to internal organs where most cancers are originated. Microelectromechanical systems (MEMS) technology offers the advantages of small size and fast speed and can be used to miniaturize optical imaging probes. The MEMS mirrors have large aperture size (1 mm × 1 mm), large scan range (> ±25°) and low drive voltage ...Comment on Article Mentions: Lei Wu Huikai Xie Shuguang Guo
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Great video Jim!
dariemihaela » Gary S. Mintz
Dear Prof. Dr. Gary S. Mintz, You are an extraordinary expert in imaging, an intelligence ...
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