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Endoscopic Functional Fourier Domain Common-Path Optical Coherence Tomography for Microsurgery
Explore Article IEEE Xplore (Aug 9 2010)
A single-arm interferometer-based optical coherence tomography (OCT) system known as common-path OCT (CP-OCT) is rapidly progressing towards practical application. Due in part to the simplicity and robustness of its design, Fourier domain CP-OCT (FD-CP-OCT) offers advantages in many endoscopic sensing and imaging applications. FD-CP-OCT uses simple, interchangeable fiber optic probes that are easily integrated into small and delicate surgical tools. The system is capable of providing not only high-resolution imaging but also optical sensing. Here, we report progress towards practical application of FD-CP-OCT in the setting of delicate microsurgical procedures such as intraocular retinal surgery. To meet the challenges presented ...
Comment on Article Mentions: Johns Hopkins University Jin U. Kang Kang Zhang
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Endoscopically guided spectral-domain OCT with double-balloon catheters
Explore Article opticsinfobase.org (Jul 30 2010)
Fourier-domain optical coherence tomography (OCT) and balloon-based catheters have furthered the potential of OCT as a real-time surveillance tool for Barrett’s esophagus (BE). However, a balloon catheter, which expands the esophagus and centers the catheter, applies direct pressure on the esophagus. This may affect the tissue appearance and the ability to detect dysplasia in BE. To study this effect, we propose a double-balloon catheter to allow imaging with and without balloon-tissue contact. A system design based on a spectral-domain OCT platform is reported and validated by acquisition of high quality, volumetric images of swine esophagus in vivo.
Comment on Article Mentions: Hui Wang Michael W. Jenkins Andrew M. Rollins
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Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon
Explore Article SPIE Digital Library (Jul 7 2010)
Amy M. Winkler, Photini F. S. Rice, Rebekah A. Drezek et al. Optical coherence tomography (OCT) can provide new insight into disease progression and therapy by enabling nondestructive, serial imaging of in vivo cancer models. In previous studies, we have shown the utility of endoscopic OCT for identifying adenomas in the azoxymethane-treated mouse model of co ... [J. Biomed. Opt. 15, 041512 (2010)] published Wed Jul 7, 2010.
Comment on Article Mentions: Jennifer K. Barton Rice University Amy M. Winkler
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Review: Diagnosis and management of Barrett’s esophagus for the endoscopist
Explore Article Therapeutic Advances in Gastroenterology (Jun 29 2010)
In Barrett’s esophagus, the stratified squamous epithelium lining the esophagus is replaced by specialized intestinal-type columnar epithelium. The prevalence of Barrett’s esophagus has ranged from 0.9% to 4.5%. The rate of progression from Barrett’s esophagus to esophageal adenocarcinoma is 0.5% per patient-year. Proton-pump inhibitors are the mainstay of symptom control in Barrett’s patients. Nondysplastic Barrett’s and Barrett’s with low-grade dysplasia (LGD) are typically managed by periodic surveillance. Radiofrequency ablation is being evaluated as a modality for managing nondysplastic Barrett’s and Barrett’s with LGD. The options for the management of Barrett’s patients with high-grade dysplasia (HGD) include endoscopic therapy, surgery, and ...
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Methods and devices for endoscopic imaging
Explore Article uspto.gov (Jun 29 2010)
Embodiments include devices and methods. One embodiment includes a method for imaging an endometrial cavity, including acquiring a plurality of images using an imaging system. A first part of the imaging system is positioned within the endometrial cavity. At least portions of two or more of the images are combined into a representation of at least a portion of the endometrial cavity. The combining at least portions of two of the images may include determining any motion of the first part of the imaging system, between the two or more of the images. Other embodiments are described and claimed.
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Forward-viewing resonant fiber-optic scanning endoscope of appropriate scanning speed for 3D OCT imaging
Explore Article opticsinfobase.org (Jun 21 2010)
A forward-viewing resonant fiber-optic endoscope of a scanning speed appropriate for a high-speed Fourier-domain optical coherence tomography (FD-OCT) system was developed to enable real-time, three-dimensional endoscopic OCT imaging. A new method was explored to conveniently tune the scanning frequency of a resonant fiber-optic scanner, by properly selecting the fiber-optic cantilever length, partially changing the mechanical property of the cantilever, and adding a weight to the cantilever tip. Systematic analyses indicated the resonant scanning frequency can be tuned over two orders of magnitude spanning from ~10Hz to ~kHz. Such a flexible scanning frequency range makes it possible to set an appropriate ...
Comment on Article Mentions: Xingde Li Johns Hopkins University
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Integrated three-dimensional scanner for endoscopic optical coherence tomography
Explore Article SPIE Digital Library (May 14 2010)
Numerous optical imaging techniques have been developed for clinical diagnostics; among these, optical coherence tomography (OCT) has proven to be of considerable utility due to its ability to non-destructively image below the surface of tissue. Endoscopic OCT systems will further extend the capabilities of this approach but require an additional means for scanning in two or three dimensions. We present an integrated optical microsystem which allows scanning of an optical beam in three dimensions (an area scan combined with dynamic focus) suitable for an endoscopic OCT probe. The system is defined by a tunable pneumatically-actuated micro-lens combined with an electrostatically-actuated ...
Comment on Article Mentions: University of Freiburg Luc Froehly FEMTO-ST Institute
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Detection of Dysplasia in Barrett's Esophagus With Angle-Resolved Low Coherence Interferometry
Explore Article Gastrointestinal Endoscopy (Mar 31 2010)
Abstracts submitted to ASGE 2010. Traditional endoscopic surveillance of Barrett's esophagus (BE) suffers from a high rate of sampling error. Angle-resolved low coherence interferometry (a/LCI) is a non-invasive method of assessing neoplastic tissue. a/LCI obtains nuclear morphology measurements of epithelial tissues by combining the depth resolution of optical coherence tomography with the sensitivity to nuclear morphology of light scattering spectroscopy. We report the results of the first complete clinical in vivo study evaluating the use of a/LCI to assess BE.Comment on Article Mentions: Yizheng Zhu Duke University Adam Wax
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Features of Sub-Epithelial Glandular Structures on Three-Dimensional Endoscopic Optical Coherence Tomography (3D-EOCT) After Endoscopic Mucosal Ablation
Explore Article Gastrointestinal Endoscopy (Mar 31 2010)
Abstracts submitted to ASGE 2010. Endoscopic mucosal ablative therapies are becoming accepted as a treatment for Barrett's esophagus (BE) with high-grade dysplasia. Radiofrequency ablation (RFA) has been shown to be effective in achieving broad and superficial BE ablation and replacement with normal-appearing squamous epithelium. Endoscopic optical coherence tomography (EOCT) is an imaging technique that uniquely allows visualization of sub-surface structures. The new three-dimensional EOCT (3D-EOCT) provides both cross-sectional and en face images of examined structures. 3D-EOCT may represent a novel method for post-ablation BE surveillance by revealing different glandular structures underneath the post-ablative surface epithelium.Comment on Article Mentions: James G. Fujimoto Joseph M. Schmitt Desmond C. Adler
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The Use of Optical Coherence Tomography in Staging Tumor Invasion of Superficial Esophageal Squamous Cell Carcinoma
Explore Article Gastrointestinal Endoscopy (Mar 31 2010)
Abstracts submitted to ASGE 2010. With the improvement of endoscopic methods, the accurate staging of superficial esophageal squamous cell carcinomas (SESCCs) has been required for curative treatment by endoscopic resection. Although endoscopic ultrasonography (EUS) is considered to be useful for the diagnosis of the indications of endoscopic resection, the accuracy has not been enough because of the poor resolution. Optical coherence tomography (OCT) is a noninvasive optical imaging modality that can perform high resolution (10-20μm), much higher than EUS, and cross-sectional imaging of tissue microstructure in real time. We demonstrated that a five-layered architecture imaged by OCT corresponded to the ... -
Barrett's Esophagus Screening Using Balloon-Based Optical Frequency Domain Imaging: A Comparison With Endoscopy
Explore Article Gastrointestinal Endoscopy (Mar 31 2010)
Abstracts submitted to ASGE 2010. Optical coherence tomography (OCT) is a high-resolution cross-sectional imaging modality that has been shown to accurately differentiate esophageal pathology relevant to screening and surveillance in Barrett's patients. We have previously demonstrated that optical frequency domain imaging (OFDI), a high speed 2nd generation embodiment of OCT, may be used to perform volumetric microscopy of the distal esophagus in patients. In this present study we compare the sensitivity of OFDI to endoscopy for the diagnosis of specialized intestinal metaplasia (SIM), using histopathology as the gold standard.Comment on Article Mentions: Melissa J. Suter Benjamin J. Vakoc Guillermo J. Tearney
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μ-vois, A Novel Three-Dimensional Microstructure Imaging System Based on Optical Coherence Tomography
Explore Article Gastrointestinal Endoscopy (Mar 31 2010)
Abstracts submitted to ASGE 2010. Micrometer-Volumetric Optical Imaging System (μ-VOIS, FUJIFILM) is a novel imaging system which is based on Fourier Domain Optical Coherence Tomography (FD-OCT) using laser beams. The in vivo resolution is approximately 10 μm and depth of penetration is limited to 1.5-2 mm. The μ-VOIS can visualize a three-dimensional (3D) cross sectional image at any region. Segmentation of tissue microstructure, such as muscularis mucosa (MM), and 3D imaging is useful for greater understanding of tissue structure.Comment on Article Mentions: Fujifilm Medical Systems
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System and method for positioning a probe
Explore Article uspto.gov (Mar 23 2010)
An adapter couples a length of optical fiber to a hollow probe and to an optical coherence tomography instrument. The length of optical fiber may be greater than the length of the adapter itself. The optical fiber is fixed to an optical coupler at a proximal end of the adapter and may be maintained in a curved configuration by features located in an internal cavity of the adapter. An optical fiber advance mechanism be used to advance and/or retract the length of optical fiber to align it within the hollow probe.
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Optical coherence tomography for the staging of tumor infiltration in superficial esophageal squamous cell carcinoma
Explore Article Gastrointestinal Endoscopy (Mar 21 2010)
Background: Optical coherence tomography (OCT) is a noninvasive technology that can produce high-resolution cross-sectional images in real-time without acoustic coupling, enabling precise assessment of tumor invasion in superficial esophageal squamous cell carcinomas (SESCCs).Objective: To elucidate the usefulness of in vivo OCT for the staging of SESCCs.Design: A single-center, prospective study in 2 phases: phase I to establish the OCT criteria classified into 3 categories (epithelium or lamina propria mucosa [EP/LPM], muscularis mucosa [MM], submucosa [SM]) and phase II to evaluate these criteria.Setting: An academic medical center.Patients: Sixty-two patients with a histological diagnosis of SESCC by routine endoscopy. In the phase ...
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Progress toward inexpensive endoscopic high-resolution common-path OCT
Explore Article SPIE Digital Library (Feb 24 2010)
Presented in this work is our effort to develop a simple, inexpensive high resolution fiber-optic Optical Coherence Tomography. The approach is based on common-path Fourier Domain OCT (CP-FDOCT), which can lead to applications for both microsurgical tool control and high-resolution endoscopic imaging. The system utilizes a combination of standard fiber optic components and novel signal processing techniques in order to achieve high axial resolution and to simplify the system. High axial resolution is achieved by implementing the Enhanced Lee filter to reduce speckle noise in the OCT image and Richardson-Lucy deconvolution algorithm afterwards to suppress sidelobes induced by the system's ...
Comment on Article Mentions: Jin U. Kang Johns Hopkins University
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Great video Jim!
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Dear Prof. Dr. Gary S. Mintz, You are an extraordinary expert in imaging, an intelligence ...
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