1. Articles in category: Microscopy

    1-24 of 395 1 2 3 4 ... 15 16 17 »
    1. Massachusetts General Hospital Receives NIH Grant for High Resolution Optical Imaging

      Massachusetts General Hospital Receives NIH Grant for High Resolution Optical Imaging

      Massachusetts General Hospital Receives a 2015 NIH Grant for $285,859 for High Resolution Optical Imaging. The principal investigator is David Boas. The program began in 2015 and ends in 2015. Below is a summary of the proposed work.

      This core will support the theme of functional coupling between glial, endothelial, and neuronal cells by using both in vivo and in vitro novel optical imaging to dissect the mechanisms of brain plasticity after cerebral ischemia . Novel optical imaging technologies have unique capability to measure the dynamics of glia, endothelium, and neurons as well as hemodynamic, metabolic, and electrophysiologic responses upon ...

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    2. Method and device for high resolution full field interference microscopy

      Method and device for high resolution full field interference microscopy

      The invention relates to an incoherent light full field interference microscopy device for the imaging of a volumetric scattering sample (106). The device comprises an interference device (100) between a reference wave (401), produced by reflection of an incident wave by a reflective surface (105) of a reference arm of the interference device, and an object wave (402) produced by backscattering of the incident wave by a slice of the sample, an acquisition device (108) for at least a first interference signal and at least a second interference signal resulting from the interference of the reference and object waves, the ...

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    3. Fibre-coupled multiphoton microscope with adaptive motion compensation

      Fibre-coupled multiphoton microscope with adaptive motion compensation

      To address the challenge of sample motion during in vivo imaging, we present a fibre-coupled multiphoton microscope with active axial motion compensation. The position of the sample surface is measured using optical coherence tomography and fed back to a piezo actuator that adjusts the axial location of the objective to compensate for sample motion. We characterise the system’s performance and demonstrate that it can compensate for axial sample velocities up to 700 µm/s. Finally we illustrate the impact of motion compensation when imaging multiphoton excited autofluorescence in ex vivo mouse skin.

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    4. Optical coherence photoacoustic microscopy for in vivo multimodal retinal imaging

      Optical coherence photoacoustic microscopy for in vivo multimodal retinal imaging

      We developed an optical coherence photoacoustic microscopy (OC-PAM) system, which can accomplish optical coherence tomography (OCT) and photoacoustic microscopy (PAM) simultaneously by using a single pulsed broadband light source. With a center wavelength of 800 nm and a bandwidth of 30 nm, the system is suitable for imaging the retina. Generated from the same group of photons, the OCT and PAM images are intrinsically registered in the lateral directions. To test the capabilities of the system on multimodal ophthalmic imaging, we imaged the retina of pigmented rats. The OCT images showed the retinal structures with quality similar to conventional OCT ...

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    5. Development of cellular resolution Gabor-domain optical coherence microscopy for biomedical applications

      Development of cellular resolution Gabor-domain optical coherence microscopy for biomedical applications

      We have developed a cellular resolution imaging modality, Gabor-Domain Optical Coherence Microscopy, which combines the high lateral resolution of confocal microscopy with the high sectioning capability of optical coherence tomography to image deep layers in tissues with high-contrast and volumetric resolution of 2 μm. A novelty of the custom microscope is the biomimetics that incorporates a liquid lens, as in whales’s eyes, for robust and rapid acquisition of volumetric imaging of deep layers in tissue down to 2 mm, thus overcoming the tradeoff between lateral resolution and depth of focus. The system incorporates a handheld scanning optical imaging head ...

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    6. Hybrid ultrahigh resolution optical coherence / photoacoustic microscopy

      Hybrid ultrahigh resolution optical coherence / photoacoustic microscopy

      We present an ultrahigh resolution dual modality optical resolution photoacoustic microsopy (OR-PAM) and spectral domain optical coherence microscopy (SD-OCM) system. The ultrahigh sub-micron lateral resolution is provided by the high numerical aperture of the objective lens used while the ultrahigh axial resolution is provided by the broadband OCT laser that covers 107 nm with a central wavelength of 840 nm. The synchronized simultaneous acquisition for the two modalities is achieved using a 40MHz FPGA. 2D-scanning is realized by two orthogonal translation stages (PI, 400 nm resolution). The transversal resolution of the system is 0.5 μm, the axial resolutions are ...

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    7. Heads Up Displays For Optical Coherence Tomography Integrated Surgical Microscopes

      Heads Up Displays For Optical Coherence Tomography Integrated Surgical Microscopes

      Surgical microscope systems are provided including an optical coherence tomography (OCT) system; an objective lens; oculars for direct viewing of a subject distal to the objective lens; a heads up display module configured to direct an optical image through the oculars to be visible to a user of at least one ocular; and a coupling element connected to the surgical microscope coupling the OCT system, the heads up display module and the objective lens.

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    8. Microscope System, And Method For Providing Augmented Reality Images Of Microscope System

      Microscope System, And Method For Providing Augmented Reality Images Of Microscope System

      Provided is a microscope system. The system comprises: an optical microscope unit for collecting a surface image of an object to be examined; an OCT unit for collecting an optical coherence tomography image of the object to be examined; a PA unit for collecting a photoacoustic image of the object to be examined; an image processing unit for generating an augmented reality image by superimposing the optical coherence tomography image and the photoacoustic image over the surface image; and an image observation unit for making the augmented reality image visible.

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    9. Towards model-based adaptive optics optical coherence tomography

      Towards model-based adaptive optics optical coherence tomography

      The transfer function for optical wavefront aberrations in single-mode fiber based optical coherence tomography is determined. The loss in measured OCT signal due to optical wavefront aberrations is quantified using Fresnel propagation and the calculation of overlap integrals. A distinction is made between a model for a mirror and a scattering medium model. The model predictions are validated with measurements on a mirror and a scattering medium obtained with an adaptive optics optical coherence tomography setup. Furthermore, a one-step defocus correction, based on a single A-scan measurement, is derived from the model and verified. Finally, the pseudo-convex structure of the ...

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    10. Functional optical coherence tomography reveals transient phototropic change of photoreceptor outer segments

      Functional optical coherence tomography reveals transient phototropic change of photoreceptor outer segments

      Dynamic near infrared microscopy has revealed transient retinal phototropism (TRP) correlated with oblique light stimulation. Here, by developing a hybrid confocal microscopy and optical coherence tomography (OCT), we tested sub-cellular source of the TRP in living frog retina. Dynamic confocal microscopy and OCT consistently revealed photoreceptor outer segments as the anatomic source of the TRP. Further investigation of the TRP can provide insights in better understanding of Stiles–Crawford effect (SCE) on rod and cone systems, and may also promise an intrinsic biomarker for early detection of eye diseases that can produce photoreceptor dysfunction.

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    11. Line-scan Raman microscopy complements optical coherence tomography for tumor boundary detection

      Line-scan Raman microscopy complements optical coherence tomography for tumor boundary detection

      Current technique for tumor resection requires biopsy of the tumor region and histological confirmation before the surgeon can be certain that the entire tumor has been resected. This confirmation process is time consuming both for the surgeon and the patient and also requires sacrifice of healthy tissue, motivating the development of novel technologies which can enable real-time detection of tumor-healthy tissue boundary for faster and more efficient surgeries. In this study, the potential of combining structural information from optical coherence tomography (OCT) and molecular information from line-scan Raman microscopy (LSRM) for such an application is presented. The results show a ...

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    12. Surgical microscope system and method

      Surgical microscope system and method

      A microscopy system and method allow observing a fluorescent substance accumulated in a tissue. The tissue can be observed at a same time both with visible light and with fluorescent light. It is possible to observe a series of previously recorded fluorescent light images in superposition with the visible light images. An end of the series of images may be automatically determined. A thermal protective filter may be inserted into a beam path of an illuminating system at such automatically determined end of the series. Further, the fluorescent light image may be analyzed for identifying a coherent fluorescent portion thereof ...

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    13. Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution

      Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution

      Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from the portion which is based on the first radiation. Based on an interaction between the optical arrangement and the first radiation and/or the second radiation, the optical arrangement can have a first transfer function. Further, it is possible to forward at least one third radiation to the portion through ...

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    14. Yale University Receives NIH Grant for Massively Parallel Interferometric Confocal Microscopy using Degenerate Lasers

      Yale University Receives  NIH Grant  for Massively Parallel Interferometric Confocal Microscopy using Degenerate Lasers

      Yale University Receives 2014 NIH Grant for $209,850 for Massively Parallel Interferometric Confocal Microscopy using Degenerate Lasers. The principal nvestigator is Michael Choma. Below is a summary of the proposed work. Confocal microscopy uses geometric principles to generate cross-sectional images of scattering biological tissue. Traditional reflectance confocal microscopes use serial pixel acquisition, thereby limiting acquisition speeds. Parallelization of pixel acquisition would dramatically increase imaging speeds and enable the study of new kinds of physiology. For example, massively parallelized reflectance confocal microscopy would be invaluable in the emerging field of cilia-driven mucus physiology in the respiratory system. Indeed, in terms ...

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    15. Computed optical interferometric tomography for high-speed volumetric cellular imaging

      Computed optical interferometric tomography for high-speed volumetric cellular imaging

      hree-dimensional high-resolution imaging methods are important for cellular-level research. Optical coherence microscopy (OCM) is a low-coherence-based interferometry technology for cellular imaging with both high axial and lateral resolution. Using a high-numerical-aperture objective, OCM normally has a shallow depth of field and requires scanning the focus through the entire region of interest to perform volumetric imaging. With a higher-numerical-aperture objective, the image quality of OCM is affected by and more sensitive to aberrations. Interferometric synthetic aperture microscopy (ISAM) and computational adaptive optics (CAO) are computed imaging techniques that overcome the depth-of-field limitation and the effect of optical aberrations in optical coherence ...

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    16. Microscopy without Slides: An Introduction to Optical Coherence Tomography (OCT)

      Microscopy without Slides: An Introduction to Optical Coherence Tomography (OCT)

      Optical coherence tomography (OCT) is one of several exciting, advanced imaging techniques that are beginning to appear in pathology. OCT can rapidly generate photomicrograph-like images directly from tissue, without the need for glass slide histology. Because the images resemble low-to-medium magnification microscope images, pathologists should be able to adapt their existing diagnostic expertise to these novel images. Both in-vivo and specimen (ex-vivo) applications are possible; this means that advanced imaging may permit pathologists to make diagnoses directly on patient images. Advanced imaging therefore represents a fabulous opportunity for pathologists in the 21st century. This talk will focus on specimen OCT ...

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    17. Combined Reflectance Confocal Microscopy-Optical Coherence Tomography System for Imaging of Biological Tissue

      Combined Reflectance Confocal Microscopy-Optical Coherence Tomography System for Imaging of Biological Tissue

      A dual-modality apparatus for imaging of biological tissue includes a reflectance confocal microscopy (RCM) imaging apparatus and an optical coherence tomography (OCT) imaging apparatus. A first optical component reflects a first beam of light provided by a RCM imaging apparatus towards a sample and passes a second beam of light provided by an OCT imaging apparatus towards the sample, such that the first and second beam of lights share at least a portion of an imaging path.

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    18. Two-dimensional confocal imaging using OCT light source and scan optics

      Two-dimensional confocal imaging using OCT light source and scan optics

      Various approaches are disclosed for simultaneously generating optical coherence tomography (OCT) and confocal scanning laser images by spatially separating the signal normally used for OCT imaging with selective reflecting or beam directing devices. In one preferred embodiment, the invention includes a mirror having a central transmission region, such that the radially outer region of the returning signal beam is reflected and used for generating a confocal image while the central part of the signal beam is transmitted and used to generate an OCT image. In other embodiments, the signals may be spatially separated in other ways, such as with an ...

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    19. Light sheet imaging the Airy way

      Light sheet imaging the Airy way

      Recent decades have seen an expansion in the breadth of light-based imaging techniques that address problems in biomedicine. Despite perceived limitations in terms of penetration depth and resolution, optical imaging has made significant strides to encroach upon the traditional territory of other modalities, such as electron microscopy and x-ray. At the nanoscale, optical methods exploit light fields in tandem with the properties of fluorescent proteins to answer biological questions in neuroscience and virology that were previously restricted to electron microscopy. At the larger scale, the same methods are making headway to generate biopsies solely with light. A prime example is ...

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    20. Surgical microscopes using optical coherence tomography and related methods

      Surgical microscopes using optical coherence tomography and related methods

      Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls ...

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    21. Super-resolution and origami microscopes scoop R&D 100 awards

      Super-resolution and origami microscopes scoop R&D 100 awards

      Super-resolution microscopes from Carl Zeiss and Leica Microsystems are among more than a dozen optics and photonics innovations to win one of this year’s R&D 100 Awards. Intended to recognize the 100 “most technologically significant products” introduced over the past year, the list also includes an all-fiber isolator from AdValue Photonics, an optical coherence tomography (OCT) diagnostic endoscope developed by NinePoint Medical, and a lunar laser communication system co-developed by NASA and MIT’s Lincoln Laboratory. In the microscopy sector, the R&D Magazine judging panel selected several winners, with Zeiss noted for the latest incarnation of its ...

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    22. Physical Sciences Receives NIH Grant for Optical Coherence Tomography Based on Freeze Drying Microscopy

      Physical Sciences Receives NIH Grant for Optical Coherence Tomography Based on Freeze Drying Microscopy

      Physical Sciences Incorporated Received a 2014 NIH Grant for $538,335 for Optical Coherence Tomography Based on Freeze Drying Microscopy. The principal investigator is Mircea Mujat. The program began in 2009 and ends in 2015. Below is a summary of the proposed work. Physical Sciences Inc. (PSI), in collaboration with the University of Connecticut (UConn), proposes to develop the 2nd generation of an advanced 3D freeze-drying microscopy (FDM) system to advance the understanding of freeze-drying and to enable the development of efficient commercial freeze drying processes. During the Phase I program PSI demonstrated the application of Optical Coherence Tomography (OCT ...

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