Microscopy -Optical Coherence Tomography News

Articles in category: Microscopy

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1. Bimodal endoscopic probe combining white-light microscopy and optical coherence tomography
  
  Explore Optica Publishing Group Nov 20 2022 Microscopy , Probes
  
  We present a novel bimodal endoscopic imaging probe that can simultaneously provide full-field white-light video microscopy and confocal optical coherence tomography (OCT) depth scans. The two modalities rely on spectrally separated optical paths that run partially in parallel through a micro-optical bench system, which has a cross-section of only 2 mm × 2.76 mm 2 mm×2.76 mm and is realized via standard silicon micromachining techniques. With a numerical aperture of 0.061, the video modality has a resolution and field of view of 9.3 and 1240 μm × 1080 μm 1240 μm×1080 μm , respectively. The resolution is ...
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  Mentions: University of Freiburg
2. Aquyre Biosciences Reaches Major Procedure Milestone During Lung Awareness Month
  
  Explore Optical Coherence Tomography News Nov 17 2022 Microscopy , Pulmonology
  
  Aquyre Biosciences recognizes Lung Cancer Awareness Month by reaching a milestone of over 400 lung biopsy procedures completed using the CelTivity ™ microscopic system. CelTivity provides an easy-to-read image, like a PET scan for cells, making cancer cells glow. Physicians found that by using CelTivity they had a significantly higher rate of cancer detection (96%), compared to traditional methods (57%). By using CelTivity, physicians can be more confident in their findings and quickly provide diagnosis guidance to patients. CelTivity is the only microscopic system on the market to provide physicians with a non-destructive Rapid On-Site Evaluation (ROSE) of a biopsy for ...
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  Mentions: University of Pittsburgh Aquyre Biosciences
3. Quantum Optical Coherence Microscopy for Bioimaging Applications
  
  Explore journals.aps.org Sep 22 2022 Microscopy
  
  Quantum-optical coherence tomography (QOCT) is an optical sectioning modality based on the quantum interference of entangled photon pairs in the well-known Hong-Ou-Mandel interferometer. Despite its promise, the technique is far from being competitive with current classical OCT devices due to the long required acquisition times, derived from the low photon-pair emission rates. In this work, we, on the one hand, demonstrate a quantum optical coherence microscopy technique, based on full-field QOCT, which employs entangled collinear photon pairs in a Linnik interferometer designed to overcome some of the limitations of previous QOCT implementations, and, on the other hand, test it on ...
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4. Mapping ciliary activity using phase resolved spectrally encoded interferometric microscopy
  
  Explore uspto.gov Sep 21 2022 Microscopy , Patents
  
  Ciliary motion in the upper airway is the primary mechanism by which the body transports foreign particulate out of the respiratory system. The ciliary beating frequency (CBF) is often disrupted with the onset of disease. Current imaging of ciliary motion relies on microscopy and high speed cameras, which cannot be easily adapted to in-vivo imaging. M-mode optical coherence tomography (OCT) imaging is capable of visualization of ciliary activity, but the field of view is limited.
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  Mentions: UC Irvine
5. Corneal imaging with blue-light optical coherence microscopy
  
  Explore Optica Publishing Group Aug 30 2022 Microscopy , Ophthalmology
  
  Corneal imaging is important for the diagnostic and therapeutic evaluation of many eye diseases. Optical coherence tomography (OCT) is extensively used in ocular imaging due to its non-invasive and high-resolution volumetric imaging characteristics. Optical coherence microscopy (OCM) is a technical variation of OCT that can image the cornea with cellular resolution. Here, we demonstrate a blue-light OCM as a low-cost and easily reproducible system to visualize corneal cellular structures such as epithelial cells, endothelial cells, keratocytes, and collagen bundles within stromal lamellae. Our blue-light OCM system achieved an axial resolution of 12 µm in tissue over a 1.2 mm ...
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  Mentions: Oregon Health & Science University University of British Columbia Center for Ophthalmic Optics and Lasers
6. Dynamic full-field optical coherence tomography as complementary tool in fungal diagnostics
  
  Explore ScienceDirect Jun 24 2022 Microscopy , NDE/NDT , Other Non-Medical
  
  Histopathology and microscopic examination of infected tissue are the gold standards to prove the diagnosis of invasive fungal infection (IFI). Yet, they suffer from essential limitations that hamper rapid diagnosis and require the future development of new imaging tools dedicated to fungal diagnostics. To this end, the present work introduces the first use of dynamic full-field optical coherence tomography (D-FF-OCT) for the visualization of microscopic filamentous fungi. Data collected from the observation of three different fungal species (Nannizzia gypsea, Aspergillus fumigatus and Rhizopus arrhizus) confirm the ability of D-FF-OCT to visualize not only the main structures of all selected fungal ...
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7. Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia
  
  Explore Optica Publishing Group Jun 21 2022 Gastroenterology , Microscopy , Pulmonology , Probes
  
  We report the design and fabrication of a flexible, longitudinally scanning high-resolution micro-optical coherence tomography (μOCT) endobronchial probe, optimized for micro-anatomical imaging in airways. The 2.4 mm diameter and flexibility of the probe allows it to be inserted into the instrument channel of a standard bronchoscope, enabling real-time video guidance of probe placement. To generate a depth-of-focus enhancing annular beam, we utilized a new fabrication method, whereby a hollow glass ferrule was angle-polished and gold-coated to produce an elongated annular reflector. We present validation data that verifies the preservation of linear scanning, despite the use of flexible materials. When ...
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  Mentions: Massachusetts General Hospital University of Alabama Harvard University
8. Augmented reality offers enhanced visualization and improved ergonomics
  
  Explore Ophthalmology Times Jun 7 2022 Microscopy , Ophthalmology
  
  As the medical director of a recently opened retina practice that I launched after many years in a group practice, I was gratified to have the opportunity to be among the first retinal surgeons in the US to perform surgery with the assistance of this platform. When operating with the Beyeonics One system, we viewed the surgical field in 3D through the surgical headset rather than on an external screen, such as those associated with “heads up” surgical systems. The setup places me at a control center, where I can use the platform to access optical coherence tomography images and ...
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  Mentions: Beyeonics
9. Pilot Study of Biopsy Scanner for Evaluation of Bronchoscopic Small Biopsy Specimens to Determine Adequacy
  
  Explore Home - ClinicalTrials.gov May 26 2022 Microscopy , Pulmonology , Clinical Trials
  
  In this study, lymph node or lung nodule tissue will be collected by bronchoscopy as part of standard clinical care. The tissue is being collected to help make a diagnosis of a pulmonary condition. The same amount of tissue that is collected per standard of care for diagnosis will be collected during the study; no additional tissue is taken for this study. The biopsy sample will be analyzed by the Aquyre Biopsy Scanner which will provide images of unprocessed lung biopsy tissue taken during your procedure. A pathologist will also analyze the tissue sample in accordance with existing clinical guidelines ...
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  Mentions: National Institutes of Health Boston University Aquyre Biosciences
10. Fast Track Diagnosis of Skin Cancer by Advanced Imaging Technologies and Tumour Tapestripping
  
  Explore Home - ClinicalTrials.gov May 24 2022 Dermatology , Microscopy , Clinical Trials
  
  Conditions : Skin Cancer; Malignant Melanoma Intervention : Diagnostic Test: Reflectance confocal microscopy (RCM), Photoacoustic imaging (PAI) and tape-strippng of RNA and lipids Sponsor : University Hospital Bispebjerg and Frederiksberg Recruiting
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11. Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles
  
  Explore Medical Journals Publisher May 12 2022 Microscopy
  
  Label-free detection of nanoparticles is essential for a thorough evaluation of their cellular effects. In particular, nanoparticles intended for medical applications must be carefully analyzed in terms of their interactions with cells, tissues, and organs. Since the labeling causes a strong change in the physicochemical properties and thus also alters the interactions of the particles with the surrounding tissue, the use of fluorescently labeled particles is inadequate to characterize the effects of unlabeled particles. Further, labeling may affect cellular uptake and biocompatibility of nanoparticles. Thus, label-free techniques have been recently developed and implemented to ensure a reliable characterization of nanoparticles ...
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  Mentions: University of Erlangen Ludwig-Maximilians University
12. Dynamic wavefront distortion in resonant scanners
  
  Explore OSA | OSA Publishing Dec 13 2021 Microscopy , Probes
  
  Dynamic mirror deformation can substantially degrade the performance of optical instruments using resonant scanners. Here, we evaluate two scanners with resonant frequencies > 12 k H z >12kHz with low dynamic distortion. First, we tested an existing galvanometric motor with a novel, to the best of our knowledge, mirror substrate material, silicon carbide, which resonates at 13.8 kHz. This material is stiffer than conventional optical glasses and has lower manufacturing toxicity than beryllium, the stiffest material currently used for this application. Then, we tested a biaxial microelectromechanical (MEMS) scanner with the resonant axis operating at 29.4 kHz. Dynamic deformation ...
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  Mentions: Superlum Stanford University Electro-Optical Products Corporation
13. Applicability of a Cellular Resolution Full-field OCT Image System for Pigmented and Non-pigmented Skin Tumors
  
  Explore Home - ClinicalTrials.gov Oct 5 2021 Dermatology , Microscopy , Oncology , Clinical Trials
  
  The incidence of skin cancer has been continuously increasing over the past decades und the number of non melanoma skin cancer is well as melanoma is still going to increase. Invasive biopsy and histological examination represents the gold standard in diagnosis of benign and malignant skin tumors. However, novel technologies such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) have been introduced in dermatology. Multiple studies have shown the applicability of both technologies for diagnosis of skin tumors as well as other skin diseases and to increase the specificity of diagnosis resulting in the reduction of unnecessary biopsies ...
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14. 1700 nm broadband laser source enables deep brain optical biopsy
  
  Explore Nature Publishing Group Oct 4 2021 Microscopy , Neurology
  
  A commentary on the article: Zhu et al. “1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain.” Light: Science & Applications 10, 145 (2021).
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15. Multimodal high-resolution embryonic imaging with light sheet fluorescence microscopy and optical coherence tomography
  
  Explore OSA | OSA Publishing Sep 1 2021 Microscopy
  
  A high-resolution imaging system combining optical coherence tomography (OCT) and light sheet fluorescence microscopy (LSFM) was developed. LSFM confined the excitation to only the focal plane, removing the out of plane fluorescence. This enabled imaging a murine embryo with higher speed and specificity than traditional fluorescence microscopy. OCT gives information about the structure of the embryo from the same plane illuminated by LSFM. The co-planar OCT and LSFM instrument was capable of performing co-registered functional and structural imaging of mouse embryos simultaneously.
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  Mentions: Baylor College of Medicine University of Houston
16. PROSCOPE project aims for early-stage bowel cancer detection
  
  Explore optics.org Aug 26 2021 Gastroenterology , Microscopy , Oncology , Funding
  
  Multimodal platform should allow cellular-level colon imaging in real-time. Improving diagnosis: PROSCOPE A project funded by the EU's Horizon 2020 program is on course to develop a new imaging system for the diagnosis of bowel cancer. PROSCOPE , officially titled "Point-of-care instrument for diagnosis and image-guided intervention of colorectal cancer," was launched in 2020 and backed by €6 million of EU funding. The project has now carried out an 18-month formal review, confirming that its research program is on target to help reduce the 160,000 deaths and €9 billion in healthcare costs associated with the disease. "Currently, only 14 ...
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  Mentions: Technical University of Denmark (DTU)
17. 1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain
  
  Explore Nature Publishing Group Jul 14 2021 Microscopy , Neurology
  
  In vivo, minimally invasive microscopy in deep cortical and sub-cortical regions of the mouse brain has been challenging. To address this challenge, we present an in vivo high numerical aperture optical coherence microscopy (OCM) approach that fully utilizes the water absorption window around 1700 nm, where ballistic attenuation in the brain is minimized. Key issues, including detector noise, excess light source noise, chromatic dispersion, and the resolution-speckle tradeoff, are analyzed and optimized. Imaging through a thinned-skull preparation that preserves intracranial space, we present volumetric imaging of cytoarchitecture and myeloarchitecture across the entire depth of the mouse neocortex, and some sub-cortical ...
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  Mentions: UC Davis
18. Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography
  
  Explore Nature Publishing Group Jun 3 2021 Microscopy
  
  Early diagnosis of ocular diseases improves the understanding of pathophysiology and aids in accurate monitoring and effective treatment. Advanced, multimodal ocular imaging platforms play a crucial role in visualization of ocular components and provide clinicians with a valuable tool for evaluating various eye diseases. Here, for the first time we present a non-contact, multiwavelength photoacoustic remote sensing (PARS) microscopy and swept-source optical coherence tomography (SS-OCT) for in-vivo functional and structural imaging of the eye. The system provides complementary imaging contrasts of optical absorption and optical scattering, and is used for simultaneous, non-contact, in-vivo imaging of murine eye. Results of vasculature ...
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  Mentions: University of Waterloo
19. Speckle-dependent accuracy in phase-sensitive optical coherence tomography
  
  Explore OSA | OSA Publishing May 17 2021 Microscopy
  
  Phase-sensitive optical coherence tomography (OCT) is used to measure motion in a range of techniques, such as Doppler OCT and optical coherence elastography (OCE). In phase-sensitive OCT, motion is typically estimated using a model of the OCT signal derived from a single reflector. However, this approach is not representative of turbid samples, such as tissue, which exhibit speckle. In this study, for the first time, we demonstrate, through theory and experiment that speckle significantly lowers the accuracy of phase-sensitive OCT in a manner not accounted for by the OCT signal-to-noise ratio (SNR). We describe how the inaccuracy in speckle reduces ...
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  Mentions: Thorlabs University College London University of Western Australia
20. Microscope
  
  Explore uspto.gov Mar 9 2021 Microscopy , Patents
  
  A microscope, comprising an observation beam path that renders an eye to be examined observable, a wavefront measuring device for measuring the refraction of the eye to be examined, an OCT device comprising an OCT illumination beam path, by means of which OCT illumination radiation can be focused as an OCT spot into the eye to be examined, and a control unit that is supplied with at least one measurement value of the wave front measuring device, is provided, wherein the control unit sets the beam diameter and/or the beam shape of the OCT spot on the basis of ...
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  Mentions: Carl Zeiss Meditec
21. Chain-like gold nanoparticle clusters for multimodal photoacoustic microscopy and optical coherence tomography enhanced molecular imaging
  
  Explore Nature Publishing Group Jan 6 2021 Microscopy
  
  Colloidal gold nanoparticles (GNPs) serve as promising contrast agents in photoacoustic (PA) imaging, yet their utility is limited due to their absorption peak in the visible window overlapping with that of hemoglobin. To overcome such limitation, this report describes an ultrapure chain-like gold nanoparticle (CGNP) clusters with a redshift peak wavelength at 650 nm. The synthesized CGNP show an excellent biocompatibility and photostability. These nanoparticles are conjugated with arginine-glycine-aspartic acid (RGD) peptides (CGNP clusters-RGD) and validated in 12 living rabbits to perform multimodal photoacoustic microscopy (PAM) and optical coherence tomography (OCT) for visualization of newly developed blood vessels in the ...
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  Mentions: University of Michigan
22. Indentation probe with optical fiber array-based optical coherence tomography for material deformation
  
  Explore Wiley Online Library Dec 16 2020 Microscopy
  
  We present a new optomechanical probe for mechanical testing of soft matter. The probe consists of a micromachined cantilever equipped with an indenting sphere, and an array of 16 single‐mode optical fibers, which are connected to an Optical Coherence Tomography (OCT) system that allows sub‐surface analysis of the sample during the indentation stroke. To test our device and its capability, we performed indentation on a PDMS‐based phantom. Our findings demonstrate that Common Path (CP)‐OCT via lensed optical fibers can be successfully combined with a microindentation sensor to visualize the phantom's deformation profile at different indentation ...
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23. Laser scanning reflection-matrix microscopy sees inside intact mouse skull
  
  Explore optics.org Dec 8 2020 Microscopy
  
  Visualizing tissues and neurons inside an animal's skull has long been a challenge for biophotonics techniques, thanks to the skull's thickness and the complex structures inside. Approaches to this problem have included the use of endoscopic platforms in brain imaging, two-photon and three-photon microscopy of small animals, and for surgical purposes the creation of a transparent window in the skull itself. A team at the Institute for Basic Science ( IBS ) in Daejeon, South Korea, has now developed a new approach to tackling the optical aberrations involved in imaging through an intact skull, and tested the system on a ...
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24. Optical comparison between micro-CT and OCT in imaging of marginal composite adaptation; Observational study
  
  Explore Wiley Online Library Nov 29 2020 Microscopy
  
  Dental composite is the most used aesthetic restorative biomaterial worldwide. However, it undergoes polymerization shrinkage that could lead to loss of the interfacial seal between tooth and resin in some circumstances. This demands high-resolution imaging technologies to detect these defects. This study carried out a comparison between microcomputed tomography (micro-CT; Shimadzu, Japan) and swept-source optical coherence tomography (SS-OCT; Santec, Japan) in the detection of marginal adaptation defects at the tooth-resin interface. Unlike in micro-CT, it was possible to outline interfacial gaps along with tooth-resin interfaces with SS-OCT, which was attributed to the Fresnel diffraction of light. This in-vitro comparison demonstrates ...
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  Mentions: Santec King Abdullah University of Science and Technology
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