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Organizations in the News
(17 articles) Harvard University
(16 articles) Massachusetts General Hospital
(13 articles) University of Illinois at Urbana-Champaign
(12 articles) Massachusetts Institute of Technology
(10 articles) University of Central Florida
(7 articles) Washington University in St. Louis
(7 articles) University of Kent
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Laser Sources for Confocal Microscopy
Explore Article SpringerLink Home (Aug 4 2010)
Laser assisted confocal microscopy has made a lot of progress over the past few years. Laser systems have become more modular and compact. There is an ever-increasing number of available laser excitation lines as well as an improvement in user friendliness and ease of use. At the same time, expansion of Web resources has provided easy access to a wealth of information. Ouf goal is both to aid the experienced and novice microscopist in quickly locating and sorting through the relevant laser information and to provide a means of avoiding common problems and pitfalls in the use of laser excitation ...
Comment on Article Mentions: University of Illinois at Urbana-Champaign
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Interlaced spectrally encoded confocal scanning laser ophthalmoscopy and spectral domain optical coherence tomography
Explore Article opticsinfobase.org (Aug 2 2010)
Scanning laser ophthalmoscopy (SLO) and spectral domain optical coherence tomography (SDOCT) have become essential clinical diagnostic tools in ophthalmology by allowing for video-rate noninvasive en face and depth-resolved visualization of retinal structure. Current generation multimodal imaging systems that combine both SLO and OCT as a means of image tracking remain complex in their hardware implementations. Here, we combine a spectrally encoded confocal scanning laser ophthalmoscope (SECSLO) with an ophthalmic SDOCT system. This novel implementation of an interlaced SECSLO-SDOCT system allows for video-rate SLO fundus images to be acquired alternately with high-resolution SDOCT B-scans as a means of image aiming, guidance, ...
Comment on Article Mentions: Yuankai K. Tao Sina Farsiu Joseph A. Izatt
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Doppler optical coherence tomography for imaging of brain hemodynamics
Explore Article Home: SPIE.org (Jul 6 2010)
Advanced microscopic techniques enable depth-resolved imaging of changes in blood flow during brain activation. ptical imaging has become an important tool in neuroscience research.1 Using methods such as optical intrinsic signal imaging (OISI), laser-Doppler imaging, and laser-speckle imaging, investigators can record changes in blood flow and blood volume in the brain, as well as alterations in blood oxygen concentration, in response to different types of stimulation. By measuring these changes, they can gain deeper insight into the functioning of the brain, which in turn can contribute to better understanding of a range of behaviors and conditions. However, these techniques typically ...
Comment on Article Mentions: James G. Fujimoto Alex E. Cable Vivek J. Srinivasan
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Interference objective for annular test surfaces
Explore Article uspto.gov (Jul 6 2010)
An apparatus including: an interferometric objective comprising a beam splitter surface configured to separate input light into test light and reference light, and a reference surface configured to receive the reference light and direct it back to the beam splitter surface, which is configured to recombine the reference light with test light reflected from a test surface, the interferometric objective further comprising one or more optical elements positioned in the path of the input light and having positive or negative optical power, wherein the reference surface is curved and defines a window to pass the input light towards the beam ...
Comment on Article Mentions: Zygo
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Gabor Domain Optical Coherence Microscopy: Assessment of a Liquid Lens Enabled In Vivo Optical Coherence Microscope
Explore Article Optical Coherence Tomography News (Jun 13 2010)
Feature Of The Week 6/13/10: Optical coherence tomography has reached unprecedented axial resolution with the development of broader and broader band sources. The promise to also reach micron level lateral resolution in OCT emerged in the mid 90s with the development of related technology Optical Coherence Microscopy (OCM). The basic concept to increasing lateral resolution is the increase in the numerical aperture (NA) of the imaging optics as resolution varies linearly with NA. The drawback to simply imaging with higher numerical aperture optics however is that the depth of focus over which the targeted lateral resolution will be maintained varies ...
Comment on Article Mentions: University of Rochester Kye-Sung Lee Supraja Murali
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Michelson Diagnostics Enters Reseller Agreement with Biotronics3D
Explore Article Optical Coherence Tomography News (Jun 10 2010)
(Orpington, UK) June 10, 2010 – Michelson Diagnostics, a leading innovator in Multi-Beam Optical Coherence Tomography (OCT) products for scientific research and healthcare imaging, has entered into a reseller agreement with UK-based Biotronics3D, a leading developer of innovative software applications for the diagnostic imaging industry. Under the terms of the agreement Michelson, will market and sell Biotronics’ 3Dnet Suite with its VivoSight Scanner and EX1301 OCT Microscope. Biotronics’ 3Dnet Suite is an FDA-cleared medical imaging display tool with powerful abilities to view and analyze 3D DICOM datasets in real time. It is already widely used by hundreds of clinicians to ...
Comment on Article Mentions: Michelson Diagnostics Michelson Diagnostics EX1301 Michelson Diagnostics Vivosight
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Assessment of a liquid lens enabled in vivo optical coherence microscope
Explore Article opticsinfobase.org (May 27 2010)
The optical aberrations induced by imaging through skin can be predicted using formulas for Seidel aberrations of a plane-parallel plate. Knowledge of these aberrations helps to guide the choice of numerical aperture (NA) of the optics we can use in an implementation of Gabor domain optical coherence microscopy (GD-OCM), where the focus is the only aberration adjustment made through depth. On this basis, a custom-designed, liquid-lens enabled dynamic focusing optical coherence microscope operating at 0.2 NA is analyzed and validated experimentally. As part of the analysis, we show that the full width at half-maximum metric, as a characteristic descriptor for ...
Comment on Article Mentions: Jannick P. Rolland Supraja Murali Kye-Sung Lee
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Anatomical and microstructural imaging of angiogenesis
Explore Article SpringerLink Home (May 12 2010)
Purpose This article reviews and discusses different options for visualizing the microarchitecture of vessels ex vivo and in vivo with respect to reliability, practicability and availability. Results and Discussion The investigation of angiogenesis by standard histological methods, like microvessel density counts, is limited since the three-dimensional (3-D) architecture and the functionality of vessels cannot be considered properly. Coregistration of immunostained images of vessels may be performed but is time consuming and often not sufficiently accurate. Confocal fluorescence microscopy is an alternative, but only enables 3-D stacks of less than 500 nm in thickness. Multiphoton microscopy and other advanced technologies, such ...
Comment on Article Mentions: RWTH Aachen University
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Cross-validation of interferometric synthetic aperture microscopy and optical coherence tomography
Explore Article opticsinfobase.org (May 10 2010)
Computationally reconstructed interferometric synthetic aperture microscopy is coregistered with optical coherence tomography (OCT) focal plane data to provide quantitative cross validation with OCT. This is accomplished through a qualitative comparison of images and a quantitative analysis of the width of the point-spread function in simulation and experiment. The width of the ISAM point-spread function is seen to be independent of depth, in contrast to OCT.
Comment on Article Mentions: Steven G. Adie Tyler S. Ralston Daniel L. Marks
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Hybrid-scanning optical-resolution photoacoustic microscopy for in vivo vasculature imaging
Explore Article opticsinfobase.org (May 3 2010)
Recently developed optical-resolution photoacoustic microscopy (OR-PAM), which is based on the detection of optical absorption contrast, is complementary to other optical microscopy modalities such as optical confocal microscopy, optical coherence tomography, and multiphoton microscopy. A hybrid optical–mechanical scanning configuration increases the imaging speed of OR-PAM significantly, facilitating many demanding biomedical applications. With a high-pulse-repetition-rate laser, the hybrid-scanning OR-PAM can acquire one-dimensional depth-resolved images (A-lines) at 5 kHz and two-dimensional B-scan images containing 800 A-lines at 6.25 Hz. We demonstrated in vivo in a mouse three-dimensional imaging of the iris vasculature in 128 s for an 800×800×200 data set and of ...
Comment on Article Mentions: Li Li Lihong V. Wang Konstantin I. Maslov
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Looking for a new generation of MEMS-type confocal microscopes
Explore Article SpringerLink Home (Apr 28 2010)
In the field of optical scanning microscopy the micro-scale or nano-scale samples are observed and analysed via large macro-tools, too bulky and heavy for individual use in specialised key missions such as in situ or in vivo measuring. A need for compact, robust scanning devices for endoscopic applications has stimulated the development of MEMS scanning mirrors for confocal imaging and for optical coherence tomography. The architecture of proposed on-chip confocal microscope is shown in Fig. 1 [1]. The individual microscope consists of two microlens scanner chips, a beamsplitter, a PIN detector and a pinhole aperture. The microlens scanner chips have ...
Comment on Article Mentions: FEMTO-ST Institute
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Ophthalmologic surgical microscope having a measuring unit
Explore Article uspto.gov (Apr 20 2010)
A surgical microscope (100) for ophthalmology includes a measuring unit (110) for determining at least one characteristic value of a patient eye (104). The measuring unit (110) is connected to a computer unit (120) which calculates a model of the patient eye (104) based on the determined characteristic variables. The surgical microscope also includes a display device for displaying the calculated model of the patient eye (104) or characteristic variables that are derived from the calculated model.
Comment on Article Mentions: Carl Zeiss Meditec
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Polarimetry of birefringent biological tissues with arbitrary fibril orientation and variable incidence angle
Explore Article opticsinfobase.org (Apr 12 2010)
Polarimetric optical techniques such as polarization microscopy or polarization-sensitive optical coherence tomography normally assume that light is perpendicular to the sample surface and that fibrils of a birefringent biological tissue are arranged in a plane parallel to this surface. The approaches that describe quantitatively polarimetric data from tissues with nonparallel fibril orientation and/or off-axis incidence usually lack a rigorous theoretical analysis. We present a polarimetric model with arbitrary fibril orientation and/or variable incidence angle by means of the extended Jones matrix theory, the polar decomposition, and Poincaré equivalence theorem. The model, suitable for diagnosis or tissue structure analysis, is applied ...
Comment on Article Mentions: University of Cantabria
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Optical Coherence Tomography in the Kidney: A Step Toward Echo Microscopy
Explore Article The Journal of Urology (Mar 16 2010)
Optical coherence tomography (OCT) can present noninvasive cross-sectional images of internal tissue microstructure by measuring their optical reflections of a light beam of super luminescent diodes. Recently, swept laser has been used as a light source and has achieved high speed and resolution images with 1 to 15 μm resolution. The high resolution OCT imaging is performed in a way similar to the ultrasonic echo imaging but it uses the echo of lasers with extremely short pulses (femtosecond lasers) with 100 times finer resolution than ultrasound echo, so that OCT can be a step toward the development of laser echo ...
Comment on Article Mentions: University of Tokyo
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System and method for enhancing microscopic images of tissue
Explore Article uspto.gov (Mar 9 2010)
A system and method for enhancing images of ex-vivo or in-vivo tissue produced by confocal microscopy, optical coherence tomography, two-photon microscopy, or ultrasound, is provided by applying to the tissue a solution or gel having an effective concentration of citric or other alpha-hydroxy acid which enhances tissue structures, such as cellular nuclei, in such images. Such concentration may be 3-20% acid, and preferably 5% acid.
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Eric Swanson » Jim Fujimoto video: Biophotonics and optical coherence tomography
Great video Jim!
dariemihaela » Gary S. Mintz
Dear Prof. Dr. Gary S. Mintz, You are an extraordinary expert in imaging, an intelligence ...
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