1. Articles in category: Dermatology

    265-288 of 516 « 1 2 ... 9 10 11 12 13 14 15 ... 20 21 22 »
    1. Determining The Extent Of A Structure On Or In The Skin Of A Subject

      Determining The Extent Of A Structure On Or In The Skin Of A Subject

      A method of and determining the extent of a structure (1), such as a non- melanoma skin cancer, in or on the skin of a subject, the method comprising the steps of: placing an index marker (3) on the skin adjacent to the structure (1); positioning an optical coherence tomography device (8) relative to the index marker; using the optical coherence tomography device (8) to image the structure (1) so as to create an image of a cross- section through the skin determining the position of an edge of the structure (1) in the image; and translating that position of ...

      Read Full Article
    2. Optical Coherence-domain Imaging of Subcutaneous Human Blood Vessels in vivo

      Optical Coherence-domain Imaging of Subcutaneous Human Blood Vessels in vivo

      Experimental methods of Optical Coherence Tomography (OCT) are applied for two-dimensional mapping of subcutaneous human blood vessels. Structural images of in vivo human finger and human palm macro vessels (0.2-1.0 mm) before and after optical clearing using the modified low power rapid scanning optical delay line are presented. Images are scanned with 12 µm minimum spatial resolution. The described modifications enable to apply low power (0.4-0.5 mW), low noise broadband near infrared light source and to obtain structural images with detection of not only reflected but also multiply scattered coherence-gated photons. The achieved transcutaneous probing depth ...

      Read Full Article
    3. Multimodal in vivo skin imaging with integrated optical coherence and multiphoton microscopy

      Multimodal in vivo skin imaging with integrated optical coherence and multiphoton microscopy
      In this paper we demonstrate high resolution, multimodal in vivo imaging of human skin using optical coherence (OCM) and multiphoton microscopy (MPM). These two modalities are integrated into a single instrument to enable simultaneous acquisition and co-registration. The system design and the OCM image processing architecture enable sufficient performance of both modalities for in vivo imaging of human skin. Examples of multimodal in vivo imaging are presented as well as time lapse imaging of blood flow in single capillaries. By making use of multiple intrinsic contrast mechanisms this integrated technique improves the ability to non-invasively visualize living tissue. Integrated OCM ...
      Read Full Article
    4. Non-invasive instrument for skin cancer screening demonstrated

      Non-invasive instrument for skin cancer screening demonstrated
      Andor Press Release: Skin cancer is the most common form of human cancer with annual rates continuing to climb from their current estimate of just over three million new cases each year. Although all skin cancers share the likelihood of a favourable outcome if early diagnosis and complete resection are achieved, diagnosis is invasive, subjective, lengthy and expensive involving expert visual inspection, biopsy and histopathology. Now, a joint US-Dutch team under the direction of Anita Mahadevan-Jansen, Vanderbilt University, US, has developed a non-invasive probe capable of both morphological and biochemical characterization of skin cancers. The portable instrument combines a Raman ...
      Read Full Article
    5. Feature Of The Week 12/4/11: Researchers in Hannover Germany Utilize OCT to Measure Skin Swelling Along Percutaneous Implants

      Feature Of The Week 12/4/11: Researchers in Hannover Germany Utilize OCT to Measure Skin Swelling Along Percutaneous Implants
      Researchers from the Leibniz University of Hannover (LUH), Laser Zentrum Hannover (LZH), and the Hannover Medical School (MHH) used OCT to measure skin swelling along percutaneous implants. An undistortion technique is proposed to compensate for the refractive distortions [1].Optical Coherence Tomography is a non invasive imaging modality recently used for taking high resolution optical biopsies of layered tissue structures such as the epidermis and the retina.As the OCT system captures optical distances rather than geometrical distances, the optical properties of the tissue introduce distortions into the OCT images. Therefore, model based image undistortion is an important step for ...
      Read Full Article
    6. 3D optical coherence tomography for clinical diagnosis of nonmelanoma skin cancers

      3D optical coherence tomography for clinical diagnosis of nonmelanoma skin cancers

      High-resolution frequency domain optical coherence tomography (OCT) stands out amongst a range of novel dermatologic imaging technologies, with its good detection sensitivity around -100 dB, high measurement speeds allowing real-time image acquisition and its ability to acquire high definition cross-sectional and 3D tomograms of regions greater than 1 cm2, providing tissue information comparable to conventional histopathology without the need for any contrast agents. Typical axial and transverse resolutions of state-of-the-art OCT systems range between 1–10 µm and approximately 20 µm, respectively, depending on the employed wavelength region. This review investigates the significant progress accomplished in the field of dermatologic ...

      Read Full Article
    7. Professor Julia Welzel hosts 1st International Optical Coherence Tomography User Meeting

      Professor Julia Welzel hosts 1st International Optical Coherence Tomography User Meeting

      Michelson Diagnostics Press Release - Optical Coherence Tomography, a non-invasive, real-time optical imaging modality, is an emergent in-vivo technique that allows high-resolution, 2- or 3-dimensional, cross-sectional visualisation of microstructural morphology of tissues. Based on near infrared interferometry, OCT provides depth-resolved images of tissues with resolution up to a few micrometers and depth up to several millimetres depending on tissue type 1. Recent advances in OCT technology have meant this promising technique is now emerging as an imaging tool for general clinical use. Newer OCT systems, built and cleared specifically for clinical use, have overcome many of the constraints of preceding research ...

      Read Full Article
    8. Michelson Diagnostics announces £1.912M investment to drive sales growth of revolutionary skin cancer scanner

      Michelson Diagnostics announces £1.912M investment to drive sales growth of revolutionary skin cancer scanner
      Michelson Diagnostics Press Release - Michelson Diagnostics (‘Michelson’) has announced an investment of £1.912 million by shareholders Octopus Investments (‘Octopus’), Catapult Venture Managers (‘Catapult’) and individual investors from London Business Angels. The funds will be used to expand sales & support infrastructure in USA and Europe to respond to growing demand for Michelson’s revolutionary unique laser scanning technology, which can image skin and other surface tissue at a much higher resolution than ever before.   The Company’s first product based on its patented multi-beam optical coherence tomography (OCT) technology, the VivoSight scanner, is expected to revolutionise the market for the ...
      Read Full Article
    9. The development of silk fibroin scaffolds using an indirect rapid prototyping approach: Morphological analysis and cell growth monitoring by spectral-domain optical coherence tomography

      The development of silk fibroin scaffolds using an indirect rapid prototyping approach: Morphological analysis and cell growth monitoring by spectral-domain optical coherence tomography
      To date, naturally derived biomaterials are rarely used in advanced tissue engineering (TE) methods despite their superior biocompatibility. This is because these native materials, which consist mainly of proteins and polysaccharides, do not possess the ability to withstand harsh processing conditions. Unlike synthetic polymers, natural materials degrade and decompose rapidly in the presence of chemical solvents and high temperature, respectively. Thus, the fabrication of tissue scaffolds using natural biomaterials is often carried out using conventional techniques, where the efficiency in mass transport of nutrients and removal of waste products within the construct is compromised. The present study identified silk fibroin ...
      Read Full Article
    10. Confocal laser microscopy, optical coherence tomography and transonychial water loss for in vivo investigation of nails

      Confocal laser microscopy, optical coherence tomography and transonychial water loss for in vivo investigation of nails

      Background:  Nail disorders can be diagnostically challenging to the dermatologist. Non-invasive methods might help to avoid nail biopsies. More knowledge of the typical features of healthy nails with these techniques is needed for comparison with nail diseases.Objectives:  Objectives were to describe the typical morphology of healthy nails in optical coherence tomography (OCT) and confocal laser scanning microscopy (CLSM) and to examine the influence of exposure to water on OCT features, nail-thickness as well as on the transonychial water loss before and after a hand bath.Material and Methods:  In the first part healthy nail plates were investigated with OCT ...

      Read Full Article
    11. Determining elastic properties of skin by measuring surface waves from an impulse mechanical stimulus using phase-sensitive optical coherence tomography

      Determining elastic properties of skin by measuring surface waves from an impulse mechanical stimulus using phase-sensitive optical coherence tomography

      The mechanical properties of skin are important tissue parameters that are useful for understanding skin patho-physiology, which can aid disease diagnosis and treatment. This paper presents an innovative method that employs phase-sensitive spectral-domain optical coherence tomography (PhS-OCT) to characterize the biomechanical properties of skin by measuring surface waves induced by short impulses from a home-made shaker. Experiments are carried out on single and double-layer agar–agar phantoms, of different concentrations and thickness, and on in vivo human skin, at the forearm and the palm. For each experiment, the surface wave phase-velocity dispersion curves were calculated, from which the elasticity of ...

      Read Full Article
    12. Reduction of image artifacts in three-dimensional optical coherence tomography of skin in vivo

      Reduction of image artifacts in three-dimensional optical coherence tomography of skin in vivo
      This paper presents results of in vivo studies on the effect of refractive index-matching media on image artifacts in optical coherence tomography (OCT) images of human skin. These artifacts present as streaks of artificially low backscatter and displacement or distortion of features. They are primarily caused by refraction and scattering of the OCT light beam at the skin surface. The impact of the application of glycerol and ultrasound gel is assessed on both novel skin-mimicking phantoms and in vivo human skin, including assessment of the epidermal thickening caused by the media. Based on our findings, recommendations are given for optimal ...
      Read Full Article
    13. New tool helps non-melanoma patients avoid surgery (video)

      New tool helps non-melanoma patients avoid surgery (video)
      Over 13 million Americans have recurring history of non-melanoma skin cancer. They often have scarring from biopsies and surgery. But new technology is helping to change that. A recent biopsy found skin cancer in Patrice Mollica's lower lip. she thought she would need surgery to remove it. "So I knew what the procedure was gonna be and because of the location I knew there would be scarring, so that was my concern obviously, and also to remove it," Mollica said. She got a second opinion. Doctor Erin Gilbert used a new, FDA approved device, "an optical coherence tomography scanner ...
      Read Full Article
    14. Evaluating the use of optical coherence tomography for the detection of epithelial cancers in vitro

      Evaluating the use of optical coherence tomography for the detection of epithelial cancers in vitro

      Optical coherence tomography (OCT) is a noninvasive imaging methodology that is able to image tissue to depths of over 1 mm. Many epithelial conditions, such as melanoma and oral cancers, require an invasive biopsy for diagnosis. A noninvasive, real-time, point of care method of imaging depth-resolved epithelial structure could greatly improve early diagnosis and long-term monitoring in patients. Here, we have used tissue-engineered (TE) models of normal skin and oral mucosa to generate models of melanoma and oral cancer. We have used these to determine the ability of OCT to image epithelial differences in vitro. We report that while in ...

      Read Full Article
    15. Assessment of Tumor Thickness in Melanocytic Skin Lesions: Comparison of Optical Coherence Tomography, 20-MHz Ultrasound and Histopathology

      Assessment of Tumor Thickness in Melanocytic Skin Lesions: Comparison of Optical Coherence Tomography, 20-MHz Ultrasound and Histopathology
      Background: Accurate assessment of vertical tumor size is important for surgical treatment planning of melanocytic skin lesions. High-frequency ultrasound (HFUS) is frequently used for this purpose, but overestimation of tumor thickness is known as a problem especially in thin melanocytic lesions. Optical coherence tomography (OCT) as a new imaging technique might be a promising alternative. Objective: To evaluate the ability of OCT to accurately determine the vertical tumor thickness of melanocytic skin lesions and to compare it with HFUS and histopathology in order to improve surgical planning. Methods: In this single-center study, 26 melanocytic lesions were imaged by OCT and ...
      Read Full Article
    16. Preoperative Characterization of Basal Cell Carcinoma Comparing Tumour Thickness Measurement by Optical Coherence Tomography, 20-MHz Ultrasound and Histopathology

      Preoperative Characterization of Basal Cell Carcinoma Comparing Tumour Thickness Measurement by Optical Coherence Tomography, 20-MHz Ultrasound and Histopathology
      Optical coherence tomography (OCT) is a new imaging method with promising results for several dermatological indications, including preoperative skin tumour characterization. While high-frequency ultrasound (HFUS) is frequently used for this purpose, overestimation of tumour thickness is a problem, due to subtumoral inflammatory infiltration that cannot be differentiated from tumour tissue. The aim of this single-centre study was to describe OCT features of basal cell carcinoma (BCC) and to determine vertical tumour thickness accurately, including a comparison with HFUS and histopathology. Tumour thickness values of 10 BCCs measured by OCT did not differ significantly from those measured by histopathology (median difference ...
      Read Full Article
    17. AGFA Healthcare Releases SKINTELL an OCT Dermatology Product

      AGFA Healthcare Releases SKINTELL an OCT Dermatology Product
      AGFA Healtcare, a member of the AGFA-Gevaert Group and a business unit with a revenue of ~billion Euros, quietly released a dermatology OCT product around June of 2011. For virtually every researcher who has ever built an OCT imaging system the first thing they did was image their finger so the application is far from new and while the potential market for OCT in dermatology is quite large, the technical and business challenges are non-trivial. For example the skin does a good job at keeping light out and in many, but not all, places a skin biopsy is easy to ...
      Read Full Article
    18. Feature Of The Week 10/9/11: Researchers at RWTH Aachen University Demonstrate Increased Tissue Contrast Using High-Resolution Simultaneous Dual-Band 3D OCT

      Feature Of The Week 10/9/11: Researchers at RWTH Aachen University Demonstrate Increased Tissue Contrast Using High-Resolution Simultaneous Dual-Band 3D OCT
      Classical Optical Coherence Tomography (OCT) systems represent morphological information by displaying the backscattered intensity of the OCT signal. Functional methods like spectroscopic OCT have been developed, extending the contrasting capabilities beyond morphological information. Spectroscopic information arises from wavelength dependent tissue features and has been retrieved by a time-frequency analysis of the OCT signal. However, this method requires high computational effort and is restricted to one wavelength band only.In contrast to a time frequency analysis, detecting in two distinct wavelength bands allows for covering large spectral bandwidths. Contrast enhancement is possible by encoding the spectral differences between both images into ...
      Read Full Article
    19. Optical Coherence Tomography Used as a Modality to Delineate Basal Cell Carcinoma prior to Mohs Micrographic Surgery

      Optical Coherence Tomography Used as a Modality to Delineate Basal Cell Carcinoma prior to Mohs Micrographic Surgery
      Optical coherence tomography (OCT) has potential as a modality for in vivo imaging of non-melanoma skin cancer (NMSC). By allowing identification of sub-surface margins of NMSC lesions, the use of OCT could improve the rate of complete excision and reduce the average number of stages during Mohs micrographic surgery (MMS). The objective of this study was to use OCT to delineate the apparent sub-surface margins of NMSC lesions prior to their excision by MMS. Lesions were scanned with reference to a physical marker on the skin, and the apparent margins were then identified from the OCT images and marked on ...
      Read Full Article
    20. Video on Michelson Diagnostics Vivosight Scanner In Use at a Dermatology Clinic as Seen on WABC News New York

      Video on Michelson Diagnostics Vivosight Scanner In Use at a Dermatology Clinic as Seen on WABC News New York
      The Michelson Diagnostics Vivosight scanner was recently featured on WABC News in New York. A copy of a text article can be seen Here. Dr. Erin Gilbert demonstrates the Vivosight scanner at her dermatology practice Gramercy Park Dermatology Associates which is offering the serviced in the United States. Dr. Gilbert says she charges patients $275 to use it. Part of that fee goes to the medical practice, part of it goes to the company to pay for the use of the machine.
      Read Full Article
    21. New tool to help identify skin cancers

      New tool to help identify skin cancers
      NEW YORK (WABC) -- Summer is over, but now is when those new spots come up on the skin, leaving people worried and asking is it cancer? Now there's a new tool that's helping doctors answer that question right in their office. After having skin cancer three times Amanda Bosca wants to make sure the two new dots on her face are not cancer. Related Content More: Get Health E-News To help figure it out fast, her doctor is using a new device called the Vivosight Scanner. Using multi-beam laser technology, it creates an image on the monitor showing ...
      Read Full Article
    22. Gordon McKenzie Discusses Michelson Diagnostics Dermatologic OCT Product (Video)

      Gordon McKenzie Discusses Michelson Diagnostics Dermatologic OCT Product (Video)
      Gordon McKenzie is the Director of Clinical Development at Michelson Diagnostics and oversees the clinical trials process showing the efficacy of high resolution Optical Coherence Tomography in disease management. Gordon talked to Science Capital about his work. For more information visit www.sciencecapital.co.uk.
      Read Full Article
    23. Optical coherent tomography: promising in vivo measurement of hair shaft cross section

      Optical coherent tomography: promising in vivo measurement of hair shaft cross section

      Variations in hair shaft morphology reflect ethnical diversity, but may also indicate internal diseases, nutritional deficiency, or hair and scalp disorders. The measurement and the follow-up of the hair shaft thickness over a defined period of time would be a valuable diagnostic tool in clinical practice. Standard light microscopy (LM) measurements require the epilation of hair shafts and frequently yield inaccurate values caused by the elliptic geometry of human hair shafts. Optical coherence tomography (OCT) is a noninvasive investigation method based on the principles of Michelson interferometry with a detection depth of approximately 1 mm in human skin. Two-dimensional images ...

      Read Full Article
    265-288 of 516 « 1 2 ... 9 10 11 12 13 14 15 ... 20 21 22 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (1 articles) Academic Medical Center at the University of Amsterdam
    2. (1 articles) National Institutes of Health
    3. (1 articles) University of Graz
    4. (1 articles) Ludwig Maximilian University of Munich
    5. (1 articles) University of Washington
    6. (1 articles) National Yang-Ming University
    7. (1 articles) University of Twente
    8. (1 articles) University of Catania
    9. (1 articles) Osaka University
  4. People in the News

    1. (1 articles) Ruikang K. Wang
    2. (1 articles) Dirk J. Faber
    3. (1 articles) Ton G. van Leeuwen
    4. (1 articles) Daniël M. de Bruin
    5. (1 articles) Wen-Chuan Kuo
    6. (1 articles) Woo June Choi
    7. (1 articles) Wei Chang
  5. OCT Companies in the News

    1. (1 articles) Siemens
    2. (1 articles) Michelson Diagnostics
  6. OCT Products in the News

    1. (1 articles) Michelson Diagnostics Vivosight