1. Articles in category: Dermatology

    265-288 of 491 « 1 2 ... 9 10 11 12 13 14 15 ... 19 20 21 »
    1. Revolutionary Device For Use in Detecting Non-Melanoma Skin Cancer in Real Time, Alleviates Patient Stress, Can Reduce Invasive Biopsy

      Revolutionary Device For Use in Detecting Non-Melanoma Skin Cancer in Real Time, Alleviates Patient Stress, Can Reduce Invasive Biopsy
      Michelson Diagnostics Press Release.   A revolutionary new imaging device that can detect skin cancer like no other technology - - the VivoSightâ Optical Coherence Tomography (OCT) scanner - - is now available to dermatologists in the U.S. for the first time.  The VivoSightâ scan enables clinicians to see under the skin surface instantly, providing additional information which will allow them to better treat patients with non-melanoma skin cancer. Gramercy Park Dermatology in New York City is the first medical practice in the U.S.to offer the VivoSightâ scan to patients presenting with non-melanoma skin cancer.   According to leading researcher and dermatologist Dr ...
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    2. Optical properties of neonatal skin measured in vivo as a function of age and skin pigmentation

      Optical properties of neonatal skin measured in vivo as a function of age and skin pigmentation
      Knowledge of the optical properties of neonatal skin is invaluable when developing new, or improving existing optical techniques for use at the neonatal intensive care. In this article, we present in vivo measurements of the absorption μa and reduced scattering coefficient μs′ of neonatal skin between 450 and 600 nm and assess the influence of age and skin pigmentation on the optical properties. The optical properties were measured using a spatially resolved, steady state diffuse reflectance spectroscopy setup, combined with a modified spatially resolved diffusion model. The method was validated on phantoms with known values for the absorption and reduced ...
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    3. Non-invasive imaging techniques in the diagnosis of skin diseases

      Non-invasive imaging techniques in the diagnosis of skin diseases
      Introduction: In recent years, there has been an increasing interest in non-invasive imaging techniques in clinical and investigational dermatology. Besides the growing number of biophysical methods for the assessment of skin properties, novel imaging tools have emerged and classical imaging methods are substantially improved. Areas covered: This review focuses on well established and some of the most promising imaging techniques for application in dermatology and cutaneous research. These comprise dermoscopy, sonography, confocal microscopy, multiphoton tomography and optical coherence tomography. Non-invasive imaging techniques are presented concerning their functional principles, the history of their development and their current clinical and research application ...
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    4. Non-Invasive Tools for Improving Diagnosis of Non-Melanoma Skin Cancer: A Review

      Non-Invasive Tools for Improving Diagnosis of Non-Melanoma Skin Cancer: A Review
      Background Non-melanoma skin cancers (NMSC) are the most common cancers diagnosed in the western world[i]. The need for surgical treatment of such lesions is on the increase. The fact that the majority of such lesions appear on aesthetically sensitive areas of head and neck means that a non-invasive method of diagnosis has the potential to both eliminate the need for tissue biopsy, as well as act as an adjunct to surgery to ensure minimal healthy tissue is sacrificed. MethodsA review of all literature using databases of Pubmed and Medline was carried out. All the titles and abstracts of all ...
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      Mentions: OptiScan
    5. In vivo evaluation of human skin anisotropy by polarization-sensitive optical coherence tomography

      In vivo evaluation of human skin anisotropy by polarization-sensitive optical coherence tomography
      We performed an in vivo three-dimensional analysis of anisotropic changes in the dermal birefringence of mechanically deformed human skin using polarization-sensitive optical coherence tomography (PS-OCT). The papillary-dermal birefringence of the forehead increased significantly when the skin was shrunk parallel to the body axis, and decreased significantly when the skin was shrunk perpendicular to the body axis. En-face images of the papillary-dermal birefringence revealed variations among individual subjects, and that both shrinking parallel to and stretching in perpendicular to the body axis promoted the formation of macro rope-like birefringent domains. We found that PS-OCT is useful for understanding anisotropic properties of ...
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    6. Arthritis linked to skin condition

      Arthritis linked to skin condition
      RESEARCHERS in Yorkshire are harnessing powerful new imaging technology to investigate nail disease linked to a common skin condition which they believe could help predict if patients will go on to develop arthritis. Around one in 50 people suffer from the skin condition psoriasis and as many as half go on to develop nail problems. These can leave patients in significant pain, cause disfigurement in nails and loss of function in small joints. Doctors in Leeds were the first in the world to recognise in 1956 that some patients with psoriasis also go on to develop a specific type of ...
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      Mentions: Dennis McGonagle
    7. Effect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCT

      Effect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCT
      The highly disordered refractive index distribution in skin causes multiple scattering of incident light and limits optical imaging and therapeutic depth. We hypothesize that localized mechanical compression reduces scattering by expulsing unbound water from the dermal collagen matrix, increasing protein concentration and decreasing the number of index mismatch interfaces between tissue constituents. A swept-source optical coherence tomography (OCT) system was used to assess changes in thickness and group refractive index in ex vivo porcine skin, as well as changes in signal intensity profile when imaging in vivo human skin. Compression of ex vivo porcine skin resulted in an effective strain ...
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    8. Leading Imaging Research Group uses VivoSight OCT Scanner to Assess Nail Disease in Psoriasis

      Leading Imaging Research Group uses VivoSight OCT Scanner to Assess Nail Disease in Psoriasis
      Michelson Diagnostics Press Release - Recent studies by the Musculoskeletal Biomedical Research Unit at Leeds University NHS Trust, UK, indicate that Optical Coherence Tomography has considerable potential for the evaluation of psoriatic nail disease. Nail disease, which occurs in 10-55% of patients with Psoriasis and in 53-86% of patients with Psoriatic Arthritis, is increasingly recognised to be of major clinical and research relevance. As yet there are no objective methods to diagnose and assess nail disease in these patients An initial case study, published in Dermatology, compared nail bed images produced by the Michelson Diagnostics VivoSight OCT scanner with those produced ...
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    9. Optical Coherence Tomography: A New Tool to Assess Nail Disease in Psoriasis?

      Optical Coherence Tomography: A New Tool to Assess Nail Disease in Psoriasis?

      Nail disease is a characteristic manifestation of the psoriatic disease spectrum but is poorly understood. Objective: Given the intrinsically high spatial resolution imaging capabilities of optical coherence tomography (OCT), we assessed its value in psoriatic nail disease compared to high-resolution ultrasonography (US). Methods: All fingernails in a psoriatic arthritis patient with nail changes were scanned with OCT, and findings were compared with high-resolution US. Results: US showed loss of trilaminar appearance in all nails, resulting in the nail plate being visualized as a single hyperechoic layer with inhomogeneous thickness. The OCT images showed much higher-resolution changes with prominent thickening in ...

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    10. Comparison of ex vivo optical coherence tomography with conventional frozen-section histology for visualizing basal cell carcinoma during Mohs micrographic surgery

      Comparison of ex vivo optical coherence tomography with conventional frozen-section histology for visualizing basal cell carcinoma during Mohs micrographic surgery
      Background  Mohs micrographic surgery offers high cure rates of nonmelanoma skin cancers with optimal sparing of normal tissue. However, it is generally more time-consuming and labour-intensive than traditional surgery. Optical coherence tomography (OCT) is an emergent technology that has the potential to diagnose basal cell carcinoma (BCC) in vivo.Objective  To compare the efficiency and accuracy of ex vivo OCT with frozen-section histology for identifying BCC in Mohs surgery.Methods  Thirty-eight patients were enrolled. After the stages were taken, images were captured with an OCT microscope and subsequently processed for standard frozen sections.Results  In total, 75 sections were scanned ...
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    11. Michelson Diagnostics Announces US Expansion

      Michelson Diagnostics Announces US Expansion
      Michelson Diagnostics Press Release - Orpington, Kent (UK) & Boston, MA (US): Michelson Diagnostics, the leading skin cancer imaging firm, today announced plans to expand availability of their revolutionary products for skin cancer imaging in the United States. Michelson Diagnostics has recruited Karen Miller Gillis as VP Sales & Marketing / General Manager of its new US subsidiary Michelson Diagnostics Inc. The new company is based in Massachusetts.  Karen brings 16 years’ sales and marketing experience in the medtech industry to Michelson. She has a track record of generating dramatic revenue growth, launching new products, year-after-year profitability, and capturing a significant portion of market ...
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    12. Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3D morphological skin imaging

      Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3D morphological skin imaging

      A noninvasive, multimodal photoacoustic and optical coherence tomography (PAT/OCT) scanner for three-dimensional in vivo (3D) skin imaging is described. The system employs an integrated, all optical detection scheme for both modalities in backward mode utilizing a shared 2D optical scanner with a field-of-view of ~13 × 13 mm2. The photoacoustic waves were detected using a Fabry Perot polymer film ultrasound sensor placed on the surface of the skin. The sensor is transparent in the spectral range 590-1200 nm. This permits the photoacoustic excitation beam (670-680 nm) and the OCT probe beam (1050 nm) to be transmitted through the sensor head ...

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    13. Evaluation of the atrophogenic potential of hydrocortisone 1% cream and pimecrolimus 1% cream in uninvolved forehead skin of patients with atopic dermatitis using optical coherence tomography

      Evaluation of the atrophogenic potential of hydrocortisone 1% cream and pimecrolimus 1% cream in uninvolved forehead skin of patients with atopic dermatitis using optical coherence tomography
      Topical corticosteroids are widely used to treat atopic dermatitis (AD), but their anti-inflammatory mode of action can be accompanied by several unwanted side effects including skin atrophy and telangiectasia. In this 8-week, investigator-blinded, intraindividual right-left comparison study with patients with mild-to-moderate AD, hydrocortisone 1% cream (HCT) was applied twice daily for 4 weeks on one side of forehead skin without clinical signs of AD and pimecrolimus 1% cream (PIM) on the other. Epidermal and dermal thickness were assessed by optical coherence tomography (OCT) and high frequency ultrasound respectively. Skin atrophy and telangiectasia were assessed by contact dermatoscopic photography (Dermaphot®). Treatment ...
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    14. Optical coherence tomography in dermatology: technical and clinical aspects

      Optical coherence tomography in dermatology: technical and clinical aspects

      Abstract  Optical coherence tomography (OCT), a fairly new non-invasive optical real-time imaging modality, is an emergent in vivo technique, based on the interference (Michelson interferometry) of infrared radiation and living tissues, that allows high-resolution, 2- or 3-dimensional, cross-sectional visualisation of microstructural morphology of tissues. OCT provides depth-resolved images of tissues with resolution up to a few micrometers and depth up to several millimetres depending on tissue type. The investigations using OCT to assess skin structure in clinical settings started in the past decade and consequently proved that this imaging method is useful in visualizing subsurface structures of normal skin, including ...

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    15. High-speed functional OCT with self-reconstructive Bessel illumination at 1300nm

      High-speed functional OCT with self-reconstructive Bessel illumination at 1300nm
      Cedric Blatter, Branislav Grajciar, and Christoph M. Eigenwillig et al. We present a Bessel beam illumination FDOCT setup with FDML buffered swept source at 1300nm. An extended focus is achieved due to the Bessel beam that preserves its lateral extend over a large depth range. Decoupling the illumination from the Gaussian detection improves the sensitivity as compared t ... [Proc. SPIE 8091, 809104 (2011)] published Thu Jun 09, 2011.
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    16. Structural analysis of artificial skin equivalents

      Structural analysis of artificial skin equivalents

      Artificial skin equivalents ASEs based on primary fibroblasts and keratinocytes show a high batch variance in their structural and morphological characteristics. Due to biological fluctuations and variable donor age, the growth processes of 3D tissue structure show a non constant quality. Since theses ASEs are used as testing system for chemicals, pharmaceuticals or cosmetics it is of major interest to know detailed and significant characteristics about each individual ASE. Until now, the microscopic analysis process is based on the destructive preparation of histologies allowing only the characterization on a random basis. In this study we present analytical methods to characterise ...

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    17. Angular high-speed massively parallel detection spectral-domain optical coherence tomography for speckle reduction

      Angular high-speed massively parallel detection spectral-domain optical coherence tomography for speckle reduction
      We demonstrate speckle reduction based on angular compounding using parallel-detection spectral-domain optical coherence tomography (OCT). An ultrahigh-speed two-dimensional complementary metal-oxide semiconductor camera acquired angular and spectral interference fringes (128×1024 pixels) simultaneously at 15,000 frames/s for a single lateral point. A signal-to-noise ratio improvement of 8 dB was achieved for imaging human skin in vivo by averaging 121 angle-resolved OCT images.
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    18. How histological features of basal cell carcinomas influence image quality in optical coherence tomography

      How histological features of basal cell carcinomas influence image quality in optical coherence tomography
      Optical coherence tomography (OCT) has the potential to diagnose and measure the depth of nonmelanoma skin cancer (NMSC) in skin, but some lesions appear blurred in OCT images. The aim of this study is to identify histological characteristics of basal cell carcinomas (BCC) that correlate with good quality OCT images of the same lesions. A total of 34 patients with BCC were OCT scanned. The influence of histology parameters (e.g. inflammation, sun damage of skin, carcinoma cell size) on OCT image quality was studied by comparing 15 BCC lesions easily identified compared to 19 BCC lesions that produced only ...
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    19. Optical Coherence Tomography monitoring of PDT effect on Basal Cell Carcinomas wins gold

      Optical Coherence Tomography monitoring of PDT effect on Basal Cell Carcinomas wins gold

      Michelson Diagnostics Press Release - A presentation by the Dermatology Departments at Roskilde & Gentofte Hospitals, Copenhagen which documents how Optical Coherence Tomography (OCT) can monitor the effectiveness of PDT treatment on superficial Basal Cell Carcinomas (BCCs) has been awarded gold by the 22nd World Congress of Dermatology. The investigation was carried out using the Michelson Diagnostics’ VivoSight OCT Scanner.

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    20. Strategies for Assessing the Degree of Photodamage to Skin: A Systematic Review of the Literature

      Strategies for Assessing the Degree of Photodamage to Skin: A Systematic Review of the Literature
      As our understanding of the role of ultraviolet (UV) radiation exposure in causing skin cancer continues to be enhanced, it is important that clinicians and researchers are familiar with the various methods for assessing photodamage to skin. This paper provides a systematic review of the published literature on invasive and non-invasive methods used to quantify lifetime UV exposure (‘photoageing’). Clinical examination, histopathology, immunohistochemistry, skin surface topography and ultrasound, in addition to newer technologies such as reflectance confocal microscopy (RCM), optical coherence tomography (OCT) and multiphoton tomography (MPT), were reviewed. It is concluded that histopathological solar elastosis alone should not be ...
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    21. Dynamic analysis for mental sweating of a group of eccrin sweat glands on a human fingertip by optical coherence tomography

      Dynamic analysis for mental sweating of a group of eccrin sweat glands on a human fingertip by optical coherence tomography
      OCT is highly potential for in vivo observation of human sweating dynamics which affects activity of the sympathetic nerve. In this paper, we demonstrate dynamic OCT analysis of mental sweating of a group of eccrin sweat glands. The sweating dynamics is tracked simultaneously for nineteen sweat glands by time-sequential piled-up en-face OCT images with the frame spacing of 3.3 sec. Strong non-uniformity is observed in mental sweating where the amount of excess sweat is different for each sweat gland although the sweat glands are adjacent to each other. The non-uniformity should be necessary to adjust as precisely the total ...
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      Mentions: Osaka University
    22. Quantitative principal component model for skin chromophore mapping using multi-spectral images and spatial priors

      Quantitative principal component model for skin chromophore mapping using multi-spectral images and spatial priors
      We describe a novel reconstruction algorithm based on Principal Component Analysis (PCA) applied to multi-spectral imaging data. Using numerical phantoms, based on a two layered skin model developed previously, we found analytical expressions, which convert qualitative PCA results into quantitative blood volume and oxygenation values, assuming the epidermal thickness to be known. We also evaluate the limits of accuracy of this method when the value of the epidermal thickness is not known. We show that blood volume can reliably be extracted (less than 6% error) even if the assumed thickness deviates 0.04mm from the actual value, whereas the error ...
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    23. Michelson has its sights set on US for skin cancer scanner

      Michelson has its sights set on US for skin cancer scanner
      Kent laser company with skin cancer detection breakthrough eyes US opportunity – but it needs to make sure the effectiveness of the scanner it has produced doesn’t leave its customers out of pocket. Launching a disruptive product in the US health care market despite limited resources and little track record at home Kent-based Michelson Diagnostics believes it has invented a laser scanner that offers a breakthrough in the diagnosis and treatment of skin cancer. Venture capitalists and private investors agree and have backed the business with £4.5m. More importantly, the scanner – called VivoSight – has been used by clinicians in ...
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    24. Expert views on Michelson Diagnostics

      Expert views on Michelson Diagnostics
      Is a small Kent based engineering business right to ignore the UK market for its skin cancer detection scanner? Health care experts and entrepreneurs offer their views. Gerry George, AIM research innovation fellow and professor of innovation and entrepreneurship, Imperial College London It’s appropriate to see the business behind a product like VivoSight developing its beachhead entry strategy in the US market, which is the largest consumer market for their technology. The issues to be careful about are threefold. First, for a start-up, winning a small share of a large market is much more difficult than winning a large ...
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