1. Articles in category: Dermatology

    265-288 of 637 « 1 2 ... 9 10 11 12 13 14 15 ... 25 26 27 »
    1. In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography

      In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography

      Background: Sarcoptes scabiei can be visualized with different imaging tools. Optical coherence tomography (OCT) may have the potential to describe the changes in skin morphology due to scabies infestation and visualize the parasite. Methods: Five patients from the Departments of Dermatology, Augsburg, Germany, and Roskilde, Denmark, were OCT scanned (VivoSight®; Michelson Diagnostics Ltd., UK). Mites were identified by epiluminescence and light microscopy to confirm the diagnosis. Results: OCT identified S. scabiei mites in all patients in vivo. Mites and burrows were visualized, and some detail on burrow content was provided. Conclusion: OCT can visualize S. scabiei mites in vivo, suggesting ...

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    2. Scattering imaging of skin in Fourier domain optical coherence tomography

      Scattering imaging of skin in Fourier domain optical coherence tomography

      A scattering imaging method for skin tissue in Fourier domain optical coherence tomography is proposed. In this method, parameter F image is obtained from the intensity signal as a function of the depth. Since parameter F contains only the scattering coefficient and its first order derivative, the scattering coefficient image depending on depth can be calculated from the parameter F image. Two-dimensional (2D) scattering coefficient images of palm skin are calculated after extracting the tissue interfaces in the 2D parameter F images.

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    3. Study shows VivoSight OCT could help Eyelid Cancer Surgery

      Study shows VivoSight OCT could help Eyelid Cancer Surgery

      Michelson Diagnostics Press Release - In what is believed to be the first ever study to investigate OCT (Optical Coherence Tomography) imaging of skin cancers in the eyelids and skin surrounding the eye, the Dept of Opthalmology, Maidstone and Tunbridge Wells NHS Trust have shown that OCT scanning can accurately reveal the margins of tumours. The study, which was conducted using the market leading VivoSight OCT scanner manufactured by Michelson Diagnostics, showed a positive correlation between tumour margins located using OCT and histology, the 'gold standard'. This breakthrough could ultimately lead to routine use of OCT scanning to plan delicate eyelid ...

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    4. Noninvasive characterization of fractional photothermolysis induced by ablative and non-ablativelasers with optical coherence tomography

      Noninvasive characterization of fractional photothermolysis induced by ablative and non-ablativelasers with optical coherence tomography

      In this study, an optical coherence tomography (OCT) system is implemented for the noninvasive characterization of photothermolysis in human skin induced by ablative fractional lasers (AFLs) and non-ablative fractional lasers (NAFLs). With OCT imaging, microthermal zones (MTZs) induced by fractional lasers can be noninvasively visualized, and the size of induced MTZs can be quantitatively evaluated. According to the OCT results, the center region of the induced MTZ corresponds to weaker backscattered intensity after the AFL exposure as a result of tissue volatilization by photon energy. In contrast, after the NAFL exposure, the skin tissue is damaged and coagulated but not ...

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    5. High-Definition Optical Coherence Tomography (HD-OCT)

      High-Definition Optical Coherence Tomography (HD-OCT)

      Munich Germany, Priv. Doz. Dr. Gerald Messer (Munich, Germany) makes use of an AGFA SKINTELL unit for test purpose. He is quite impressed about the new technologies performance, especially in diagnosis of non-melanoma skin cancer. A first test is so promising that a second closer look will be done with associated clinics in June. “The new High-Definition Optical Coherence Tomography (HD-OCT) technology will give the opportunity to diagnose actinic keratosis and basal cell carcinoma without intervention in an early stage where non-invasive therapies are promising”. Dr. Messer reported also some success from the DDG (Deutsche Dermatologische Gesellschaft) Congress that was ...

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    6. Interest of High Definition Optical Coherent Tomography (HD‐OCT) for imaging of melanoma

      Interest of High Definition Optical Coherent Tomography (HD‐OCT) for imaging of melanoma

      We read with interest two recent studies which established that High Definition Optical Coherent Tomography (HD-OCT), a newly released skin imaging technique, facilitates the in vivo diagnosis of non-melanoma skin cancers (1, 2). However, to the best of our knowledge there is no data available regarding HD-OCT and melanoma. A 61-year-old man, skin type II, with a previous history of melanoma 10 years before consulted for a follow-up visit. Clinical and dermoscopic examination pointed to two suspicious pigmented lesions in the right pectoral region and on the left scapula. RCM examination using a commercially available VivaScope ® 1500 (Lucid-Tech Inc., Henrietta ...

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    7. In vivo optical coherence tomography (OCT) in periocular basal cell carcinoma: correlations between in vivo OCT images and postoperative histology

      In vivo optical coherence tomography (OCT) in periocular basal cell carcinoma: correlations between in vivo OCT images and postoperative histology

      Aim To investigate in vivo optical coherence tomography (OCT) for imaging of periocular basal cell carcinoma (BCC). Methods Consecutive patients with periocular BCC were prospectively investigated with VivoSight OCT imaging prior to surgical excision. Histology sections were compared with OCT images with regard to lesion measurements (x, y and z dimensions) and histological features. Results A total of 15 patients with biopsy proven BCC were recruited. The OCT horizontal margins correlated positively with histology (r=0.8 and 0.66, x and y axes) and could be identified in 3/15 (x axis) and 6/15 (y axis) cases. The ...

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    8. Functional and structural age-related changes in the scalp skin of Caucasian women

      Functional and structural age-related changes in the scalp skin of Caucasian women

      Background Ageing of the skin, being chronological or sun induced is highly documented. Scalp, as a specific skin site, has, however, received little attention. This work attempted to describe functional and structural alterations that occur in scalp skin with ageing. Methods Two different age groups (N = 15 each; 30 ± 3 and 62 ± 2 y.o. respectively) of Caucasian women participated in the study. Some functional parameters (TEWL, Sebum level, Hydration, T°) were recorded on the vertex part of the scalp, after having cut the hair flat on the scalp surface. Imaging of some structural criteria was carried out using high-frequency ...

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    9. Calluses, Corns and Heel Fissures

      Calluses, Corns and Heel Fissures

      Hypertrophy of the plantar stratum corneum (SC) of the epidermis (also known as hyperkeratosis) is one of the skin's primary protective responses, triggered by either physiological stresses, a result of underlying disease (eg, psoriasis, palmoplantar keratoderma), or external mechanical stresses. In the case of the foot the most common presentations of hyperkeratosis are: anhidrosis, calluses, corns and heel fissures. This article reviews the current evidence in the field of hyperkeratosis of the foot and will present the treatment options available to practitioners and patients. The gaps in the knowledge surrounding the efficacy of treatments are discussed and novel methods ...

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    10. Feasibility of correlation mapping optical coherence tomography (cmOCT) for anti-spoof sub-surface fingerprinting

      Feasibility of correlation mapping optical coherence tomography (cmOCT) for anti-spoof sub-surface fingerprinting

      We propose the use of correlation mapping optical coherence tomography (cmOCT) to deliver additional biometrics associated with the finger that could complement existing fingerprint technology for law enforcement applications. The current study extends the existing fingerprint paradigm by measuring additional biometrics associated with sub-surface finger tissue such as sub-surface fingerprints, sweat glands, and the pattern of the capillary bed to yield a user-friendly cost effective and anti-spoof multi-mode biometric solution associated with the finger. To our knowledge no other method has been able to capture sub-surface fingerprint, papillary pattern and horizontal vessel pattern in a single scan or to show ...

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    11. Combined reflectance confocal microscopy/optical coherence tomography imaging for skin burn assessment

      Combined reflectance confocal microscopy/optical coherence tomography imaging for skin burn assessment

      A combined high-resolution reflectance confocal microscopy (RCM)/optical coherence tomography (OCT) instrument for assessing skin burn gravity has been built and tested. This instruments allows for visualizing skin intracellular details with submicron resolution in the RCM mode and morphological and birefringence modifications to depths on the order of 1.2 mm in the OCT mode. Preliminary testing of the dual modality imaging approach has been performed on the skin of volunteers with some burn scars and on normal and thermally-injured Epiderm FTTM skin constructs. The initial results show that these two optical technologies have complementary capabilities that can offer the ...

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    12. Positional differences and aging changes in Japanese woman epidermal thickness and corneous thickness determined by OCT (optical coherence tomography)

      Positional differences and aging changes in Japanese woman epidermal thickness and corneous thickness determined by OCT (optical coherence tomography)

      Background/purpose A number of studies of the internal structure of Japanese woman's skin are now performed by means of optical coherence tomography (OCT) as a technique capable of visualizing the internal structure in a non-invasive manner. Methods We measured the epidermal and corneous thicknesses at 11 sites in 116 healthy female volunteers aged from teens to sixties to examine possible positional differences and aging changes. Results The epidermal thickness determined at the 11 sites averaged 68.6 ± 23.0 μm (mean ± SD) and the corneous thickness averaged 14.1 ± 1.80 μm, the values of which were thinner ...

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      Mentions: Tetsuya Tsugita
    13. Optical coherence tomography: its role in daily dermatological practice

      Optical coherence tomography: its role in daily dermatological practice

      Optical coherence tomography (OCT) is a non-invasive, tomographic imaging technique which generates high-resolution in-vivo images up to mid-dermal layers. Due to continuous technological improvements, OCT is moving from research projects into daily dermatological practice. It can complement other imaging methods like high-frequency ultrasound or confocal microscopy. There is a wide variety of indications for OCT. In addition to aiding in the diagnosis and clinical monitoring of inflammatory dermatoses, OCT is a very useful and feasible technique in dermato-oncology.

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    14. Optical techniques for the noninvasive diagnosis of skin cancer

      Optical techniques for the noninvasive diagnosis of skin cancer

      Purpose The aim of this paper is to provide an overview of the most investigated optical diagnostic techniques: optical coherence tomography, fluorescence spectrometry, reflectance spectrometry, Raman spectroscopy, and confocal microscopy. Methods A search of three databases was conducted using specific keywords and explicit inclusion and exclusion criteria for the analysis of the performances of these techniques in the pre- and postoperative diagnosis of skin cancers. Results Optical coherence tomography has shown promising results in the assessment of deep margins of skin tumors and inflammatory skin diseases, but differentiating premalignant from malignant lesions proved to be less effective. Fluorescence spectroscopy proved ...

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    15. Evaluation of Moisture-Related Attenuation Coefficient and Water Diffusion Velocity in Human Skin Using Optical Coherence Tomography

      Evaluation of Moisture-Related Attenuation Coefficient and Water Diffusion Velocity in Human Skin Using Optical Coherence Tomography

      In this study, time-resolved optical coherence tomography (OCT) scanning images of the process of water diffusion in the skin that illustrate the enhancement in the backscattered intensities due to the increased water concentration are presented. In our experiments, the water concentration in the skin was increased by soaking the hand in water, and the same region of the skin was scanned and measured with the OCT system and a commercial moisture monitor every three minutes. To quantitatively analyze the moisture-related optical properties and the velocity of water diffusion in human skin, the attenuation coefficients of the skin, including the epidermis ...

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    16. Investigation of basal cell carcinoma using dynamic focus optical coherence tomography

      Investigation of basal cell carcinoma using dynamic focus optical coherence tomography

      Optical coherence tomography (OCT) is becoming a popular modality for skin tumor diagnosis and assessment of tumor size and margin status. We conducted a number of imaging experiments on periocular basal cell carcinoma (BCC) specimens using an OCT configuration. This configuration employs a dynamic focus (DF) procedure where the coherence gate moves synchronously with the peak of the confocal gate, which ensures better signal strength and preservation of transversal resolution from all depths. A DF-OCT configuration is used to illustrate morphological differences between the BCC and its surrounding healthy skin in OCT images. The OCT images are correlated with the ...

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    17. Sonography of Facial Cutaneous Basal Cell Carcinoma - A First-line Imaging Technique

      Sonography of Facial Cutaneous Basal Cell Carcinoma - A First-line Imaging Technique

      Cutaneous basal cell carcinoma is the most common cancer in human beings, and the face is its most frequent location. Basal cell carcinoma is rarely lethal but can generate a high degree of disfigurement. Of all imaging techniques, sonography has proven to support the diagnosis and provide detailed anatomic data on extension in all axes, the exact location, vascularity, and deeper involvement. This information can be used for improving management and the cosmetic results of patients. Next Section Overview and Description of the Clinical Problem Even though the diagnosis of skin cancer predominantly relies on clinical inspection, imaging techniques are ...

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    18. Optical Coherence Tomography: The first Quantitative Imaging Biomarker for Scleroderma

      Optical Coherence Tomography: The first Quantitative Imaging Biomarker for Scleroderma

      Michelson Diagnostics Press Release - Using the VivoSight OCT scanner, manufactured in the UK by Michelson Diagnostics Ltd, scientists at the Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds have developed the first quantitative imaging biomarker for skin involvement in Scleroderma. Scleroderma or Systemic Sclerosis (SSc) is a serious type of autoimmune disorder affecting approximately 1 in 10,000 people. It is a progressive disease that involves skin and internal organs by determining fibrosis, vasculopathy and immune system activation. The extent and severity of skin fibrosis is an important prognostic indicator of Scleroderma and often a primary endpoint in clinical ...

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    19. Defense of fake fingerprint attacks using a swept source laser optical coherence tomography setup

      Defense of fake fingerprint attacks using a swept source laser optical coherence tomography setup

      The most established technique for the identification at biometric access control systems is the human fingerprint. While every human fingerprint is unique, fingerprints can be faked very easily by using thin layer fakes. Because commercial fingerprint scanners use only a two-dimensional image acquisition of the finger surface, they can only hardly differentiate between real fingerprints and fingerprint fakes applied on thin layer materials. A Swept Source OCT system with an A-line rate of 20 kHz and a lateral and axial resolution of approximately 13 μm, a centre wavelength of 1320 nm and a band width of 120 nm (FWHM) was ...

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    20. Dynamic imaging of a small artery underneath skin surface of a human finger by optical coherence tomography

      Dynamic imaging of a small artery underneath skin surface of a human finger by optical coherence tomography

      OCT is a powerful tool for detection of physiological functions of micro organs underneath the human skin surface, besides the clinical application to ophthalmology, as recently demonstrated by the authors’ group. In particular, dynamics of peripheral vessels can be observed clearly in the time-sequential OCT images. Among the vascular system, only the small artery has two physiological functions both for the elastic artery and for muscle-controlled one. It, therefore, is important for dynamic analysis of blood flow and circulation. In the time-sequential OCT images obtained with 25 frames/sec, it is found that the small artery makes a sharp ...

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      Mentions: Osaka University
    21. Virtual Biopsy – is it possible?

      Virtual Biopsy – is it possible?

      In a remark made to my last post: New envelopment in measuring mechanical properties of tissue , Dr. Aviva Lev-Ari, PhD, RN, Director and Founder of our Open Access Online Scientific Journal: Leaders of Pharmaceutical Business Intelligence, asked whether OCT can be used for the purpose of performing biopsy. My answer to her question was “YES”. I thought that it will be worthwhile explaining why I am so “optimistic” about this: A conventional biopsy is a process where a tissue sample is being cut out of the body and after being subjected to all kind of chemical processes a thin-film of ...

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    22. Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative

      Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative

      The effects on skin of two commercially available topical creams for the treatment of eczema are quantitatively studied using optical coherence tomography. An archetypal corticosteroid (Betamethasone valerate) is compared with a nonsteroidal anti-inflammatory drug (Tacrolimus monohydrate) via left/right comparisons of the epidermal thickness of volar forearm skin on selected volunteers, at baseline and after 14 days of treatment. In 3 of 4 subjects we confirmed previous observations that corticosteroids produce pronounced physical thinning of the epidermis over timescales of a few weeks. In 3 of 4 subjects we further found that Tacrolimus produced no change in epidermal thickness. In ...

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    23. Non-invasive Quality Control for Production Processes of Artificial Skin Equivalents by Optical Coherence Tomography

      Non-invasive Quality Control for Production Processes of Artificial Skin Equivalents by Optical Coherence Tomography

      The engineering of artificial tissue and organs is widely gaining relevance in biotechnological and biomedical research. Particularly by the law enforced reduction of animal testing, alternative methods need to be developed to simulate and test the effects of chemical substances on human organs. Regarding the branches for pharmaceuticals, chemicals and cosmetics most products need to be tested on penetration of the human skin tissue. As an alternative method to animal testing, skin equivalents (SEs) based on tissue engineering may be used to test the skin barrier function. In the framework of a large scale research project, we built a fully ...

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