1. Articles in category: Dermatology

    265-288 of 619 « 1 2 ... 9 10 11 12 13 14 15 ... 24 25 26 »
    1. Defense of fake fingerprint attacks using a swept source laser optical coherence tomography setup

      Defense of fake fingerprint attacks using a swept source laser optical coherence tomography setup

      The most established technique for the identification at biometric access control systems is the human fingerprint. While every human fingerprint is unique, fingerprints can be faked very easily by using thin layer fakes. Because commercial fingerprint scanners use only a two-dimensional image acquisition of the finger surface, they can only hardly differentiate between real fingerprints and fingerprint fakes applied on thin layer materials. A Swept Source OCT system with an A-line rate of 20 kHz and a lateral and axial resolution of approximately 13 μm, a centre wavelength of 1320 nm and a band width of 120 nm (FWHM) was ...

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    2. Dynamic imaging of a small artery underneath skin surface of a human finger by optical coherence tomography

      Dynamic imaging of a small artery underneath skin surface of a human finger by optical coherence tomography

      OCT is a powerful tool for detection of physiological functions of micro organs underneath the human skin surface, besides the clinical application to ophthalmology, as recently demonstrated by the authors’ group. In particular, dynamics of peripheral vessels can be observed clearly in the time-sequential OCT images. Among the vascular system, only the small artery has two physiological functions both for the elastic artery and for muscle-controlled one. It, therefore, is important for dynamic analysis of blood flow and circulation. In the time-sequential OCT images obtained with 25 frames/sec, it is found that the small artery makes a sharp ...

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      Mentions: Osaka University
    3. Virtual Biopsy – is it possible?

      Virtual Biopsy – is it possible?

      In a remark made to my last post: New envelopment in measuring mechanical properties of tissue , Dr. Aviva Lev-Ari, PhD, RN, Director and Founder of our Open Access Online Scientific Journal: Leaders of Pharmaceutical Business Intelligence, asked whether OCT can be used for the purpose of performing biopsy. My answer to her question was “YES”. I thought that it will be worthwhile explaining why I am so “optimistic” about this: A conventional biopsy is a process where a tissue sample is being cut out of the body and after being subjected to all kind of chemical processes a thin-film of ...

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    4. Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative

      Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative

      The effects on skin of two commercially available topical creams for the treatment of eczema are quantitatively studied using optical coherence tomography. An archetypal corticosteroid (Betamethasone valerate) is compared with a nonsteroidal anti-inflammatory drug (Tacrolimus monohydrate) via left/right comparisons of the epidermal thickness of volar forearm skin on selected volunteers, at baseline and after 14 days of treatment. In 3 of 4 subjects we confirmed previous observations that corticosteroids produce pronounced physical thinning of the epidermis over timescales of a few weeks. In 3 of 4 subjects we further found that Tacrolimus produced no change in epidermal thickness. In ...

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    5. Non-invasive Quality Control for Production Processes of Artificial Skin Equivalents by Optical Coherence Tomography

      Non-invasive Quality Control for Production Processes of Artificial Skin Equivalents by Optical Coherence Tomography

      The engineering of artificial tissue and organs is widely gaining relevance in biotechnological and biomedical research. Particularly by the law enforced reduction of animal testing, alternative methods need to be developed to simulate and test the effects of chemical substances on human organs. Regarding the branches for pharmaceuticals, chemicals and cosmetics most products need to be tested on penetration of the human skin tissue. As an alternative method to animal testing, skin equivalents (SEs) based on tissue engineering may be used to test the skin barrier function. In the framework of a large scale research project, we built a fully ...

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    6. Optical coherence tomography imaging of telangiectasias during intense pulsed light treatment: a potential tool for rapid outcome assessment

      Optical coherence tomography imaging of telangiectasias during intense pulsed light treatment: a potential tool for rapid outcome assessment

      Vascular malformations commonly occur in the facial region, and can be associated with significant stigma and embarrassment. Studies have shown that even recommended light-based treatments do not always result in complete clearance. This indicates the need for more accurate pre-treatment assessment of vessel morphology to optimize treatment settings and identify possible morphological predictors of the outcome. Fourteen patients (six males, eight females, and aged 37–66 years) with the diagnosis of telangiectasias were enrolled and were all scanned with OCT and digitally photographed before and minutes after IPL treatment. OCT images of the telangiectasias before treatment were displayed as hyporeflective ...

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    7. In vivo microcirculation imaging of the sub surface fingertip using correlation mapping optical coherence tomography (cmOCT)

      In vivo microcirculation imaging of the sub surface fingertip using correlation mapping optical coherence tomography (cmOCT)

      We describe a novel application of correlation mapping optical coherence tomography (cmOCT) for sub-surface fingerprint biometric identification. Fingerprint biometrics including automated fingerprint identification systems, are commonly used to recognise the fingerprint, since they constitute simple, effective and valuable physical evidence. Spoofing of biometric fingerprint devices can be easily done because of the limited information obtained from the surface topography. In order to overcome this limitation a potentially more secure source of information is required for biometric identification applications. In this study, we retrieve the microcirculation map of the subsurface fingertip by use of the cmOCT technique. To increase probing depth ...

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    8. Optical coherence tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface

      Optical coherence tomography to delineate the interactions of PAMAM dendrimers with the porcine skin surface

      Polyamidoamine (PAMAM) dendrimers have been topically applied to the skin and utilised as a permeation enhancer for a range of therapeutic compounds. However, very little is known about the mechanism of enhancement. This study used optical coherence tomography (OCT) to investigate the influence of PAMAM dendrimers to alter surface refractive index (RI) in excised porcine skin. It is revealed that PAMAM dendrimers caused a sporadic disruption and disappearance of the white hyper-reflective band on the skin surface using OCT. Following the decontamination of the treated skin specimens, the entrance signal, resulting in the polarised light reflecting off the keratin of ...

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      Mentions: Ying Yang
    9. Quantitative evaluation of scattering in optical coherence tomography skin images using the extended Huygens–Fresnel theorem

      Quantitative evaluation of scattering in optical coherence tomography skin images using the extended Huygens–Fresnel theorem

      An optical properties extraction algorithm is developed based on enhanced Huygens–Fresnel light propagation theorem, to extract the scattering coefficient of a specific region in an optical coherence tomography (OCT) image. The aim is to quantitatively analyze the OCT images. The algorithm is evaluated using a set of phantoms with different concentrations of scatterers, designed based on Mie theory. The algorithm is then used to analyze basal cell carcinoma and healthy eyelid tissues, demonstrating distinguishable differences in the scattering coefficient between these tissues. In this study, we have taken advantage of the simplification introduced by the utilization of a dynamic ...

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    10. Mapping of spatial distribution of superficial blood vessels in human skin by double correlation analysis of optical coherence tomography images

      Mapping of spatial distribution of superficial blood vessels in human skin by double correlation analysis of optical coherence tomography images

      2D/3D spatial distribution of superficial blood vessels in human skin in vivo was conducted by double correlation analysis of the swept source Optical Coherence Tomography (OCT) images. An adaptive Wiener filtering technique has been employed to remove background noise and increase the overall quality of the OCT images acquired experimentally. Correlation Mapping and Fourier domain correlation approaches have been subsequently applied to enhance spatial resolution of images of vascular network in human skin. The analysis of images performed on Graphics Processing Units (GPUs) utilizing the recently developed Compute Unified Device Architecture (CUDA) framework.

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    11. Virtual skin biopsy by optical coherence tomography: the first quantitative imaging biomarker for scleroderma

      Virtual skin biopsy by optical coherence tomography: the first quantitative imaging biomarker for scleroderma

      Background Skin involvement is of major prognostic value in systemic sclerosis (SSc) and often the primary outcome in clinical trials. Nevertheless, an objective, validated biomarker of skin fibrosis is lacking. Optical coherence tomography (OCT) is an imaging technology providing high-contrast images with 4 μm resolution, comparable with microscopy (‘virtual biopsy’). The present study evaluated OCT to detect and quantify skin fibrosis in SSc. Methods We performed 458 OCT scans of hands and forearms on 21 SSc patients and 22 healthy controls. We compared the findings with histology from three skin biopsies and by correlation with clinical assessment of the skin ...

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    12. American Academy of Dermatology Session on Optical Coherence Tomography March 4th 2013.

      American Academy of Dermatology Session on Optical Coherence Tomography March 4th 2013.

      Optical coherence tomography (OCT) is a non-invasive imaging device that uses a low intensity laser light to image up to 2mm beneath the skin’s surface. This allows the clinician to get real-time video-rate images of the subsurface structures of the integumentary system without any pre-treatment or gels. OCT has been shown to be a useful diagnostic and monitoring tool. This session will highlight the practical utility of a rapidly effective imaging device in both areas of research as well as a cosmetic and general dermatology practice.

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    13. Skin Cancer Treatment without surgery: Cut-less Dermatology

      Skin Cancer Treatment without surgery: Cut-less Dermatology

      According to the Skin Cancer Foundation, one person dies from skin cancer every hour in the United States — a good reason why everyone should schedule regular skin examinations. But you may ask, how do dermatologists know when a skin growth or mole needs to be removed? In the past, every worrisome skin lesion required a biopsy, meaning a small piece of tissue was surgically removed and sent to a pathology laboratory. If the biopsy showed cancer, additional surgery was needed. Even today, surgical biopsy and removal continues to be the standard of care for skin cancer. Fortunately, we have newer ...

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    14. Studies indicate that VivoSight OCT reliably predicts tumour margins

      Studies indicate that VivoSight OCT reliably predicts tumour margins

      Michelson Diagnostics Press Release - Accurate determination of tumour margins is vital to the successful treatment of skin cancer patients. This is especially the case for patients undergoing Mohs Micrographic Surgery where complete tumour removal may require repeated invasive procedures. Recent studies conducted in two US Healthcare facilities used the VivoSight OCT scanner, manufactured in the UK by Michelson Diagnostics Ltd, to prospectively refine clinically estimated tumour margins prior to Mohs Micrographic Surgery. The first 52 patient study 1 conducted by Professor Dan Seigel (Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, New York) concluded that: “OCT ...

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    15. Optical coherence tomography in dermatology

      Optical coherence tomography in dermatology

      Optical coherence tomography (OCT) is a noninvasive diagnostic method that offers a view into the superficial layers of the skin in vivo in real-time. An infrared broadband light source allows the investigation of skin architecture and changes up to a depth of 1 to 2 mm with a resolution between 15 and 3 μ m, depending on the system used. Thus OCT enables evaluation of skin lesions, especially nonmelanoma skin cancers and inflammatory diseases, quantification of skin changes, visualization of parasitic infestations, and examination of other indications such as the investigation of nails. OCT provides a quick and useful diagnostic imaging ...

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    16. Optical Coherence Tomography–Based Optimization of Mohs Micrographic Surgery of Basal Cell Carcinoma: A Pilot Study

      Optical Coherence Tomography–Based Optimization of Mohs Micrographic Surgery of Basal Cell Carcinoma: A Pilot Study

      Background Optical coherence tomography (OCT) is a noninvasive imaging technique that uses a low-power infrared laser to image up to 2 mm beneath the skin's surface. Objective To test the feasibility and diagnostic value of using in vivo OCT to define excision margins before Mohs micrographic surgery (MMS) of basal cell carcinoma (BCC). Methods Patients with biopsy confirmed BCC undergoing MMS were recruited ( n = 52). Excision margins defined by experienced dermatologists were compared with those of OCT-assessed borders and validated with histologic assessments. Results Forty-one (79%) lesions were clear after one MMS procedure; 11 (21%) lesions required a second ...

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    17. High-definition optical coherence tomography: adapted algorithmic method for pattern analysis of inflammatory skin diseases: a pilot study

      High-definition optical coherence tomography: adapted algorithmic method for pattern analysis of inflammatory skin diseases: a pilot study

      High-definition optical coherence tomography (HD-OCT) is a non-invasive technique for morphological investigation of tissue with cellular resolution filling the imaging gap between reflectance confocal microscopy and conventional optical coherence tomography. The aim of this study is first to correlate dermatopathologic descriptors of inflammatory skin conditions with epidermal alteration to features observed by HD-OCT. Secondly, to assess the discriminative accuracy of common inflammatory reaction patterns with epidermal alteration using HD-OCT by applying Ackerman’s algorithmic method of pattern recognition. The generated HD-OCT images of 160 patients presenting an inflammatory skin disease were analyzed with respect to the following criteria: visualization of ...

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    18. Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study

      Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study

      Background Optical coherence tomography (OCT) is an evolving optical technology that is capable of delivering real-time, high-resolution signatures of tissue. Objectives The purpose of this immediate ex vivo prospective clinical study was: (1) to assess the sensitivity and specificity of OCT on biopsy material in identifying potentially malignant and malignant oral lesions, (2) to determine the inter-observer agreement in the analysis of specific image parameters, and (3) to find out the oral epithelial thickness for different pathology groups. Materials and methods This prospective study involved 125 suspicious oral lesions from 125 patients. The lesions were surgically biopsied and subjected to ...

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    19. Optical Coherence Tomography and Its Role in Mohs Micrographic Surgery: A Case Report

      Optical Coherence Tomography and Its Role in Mohs Micrographic Surgery: A Case Report

      Optical coherence tomography (OCT) is an imaging technology with the potential to provide high-resolution images of the skin non-invasively. With this device, it is possible to identify a host of skin structures including tumors. In this case report, we demonstrate the use of an OCT device in delineating a lateral tumor margin of an ill-defined basal cell carcinoma prior to Mohs micrographic surgery. Following surgery, the OCT images are compared to histologic sections to confirm their accuracy. OCT technology has the potential to be a vital tool for dermatologists and particularly Mohs surgeons in identifying tumor margins and potentially reducing ...

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    20. Microvascular and Fibrosis Imaging Study

      Microvascular and Fibrosis Imaging Study

      In this study we will use Laser Doppler Flowmetry (LDF), Laser Doppler Imaging (LDI), Orthogonal Polarization Spectral Imaging (OPSI), and Optical Coherence Tomography (OCT) to assess differences in microvascular function and density of oral mucosa and skin in subjects with 1) autoimmune diseases with cutaneous involvement: systemic sclerosis (SSc), morphea, dermatomyositis, cutaneous lupus and vasculitis, 2) sickle cell disease (SCD) and 3) chronic graft-versus-host disease (GVHD) compared to healthy subjects. We plan to compare the microvascular changes to overall treatment response in patients with scleroderma and chronic GVHD as assessments will be made before and after the patients start treatment ...

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      Mentions: Duke University
    21. High-Definition Optical Coherence Tomography for the in vivo Detection of Demodex Mites

      High-Definition Optical Coherence Tomography for the in vivo Detection of Demodex Mites

      Demodex mites are involved in different skin diseases and are commonly detected by skin scrape tests or superficial biopsies. A new high-definition optical coherence tomography (HD-OCT) with high lateral and axial resolution in a horizontal (en-face) and vertical (slice) imaging mode might offer the possibility of noninvasive and fast in vivo examination of demodex mites. Methods: Twenty patients with demodex-related skin diseases and 20 age- and gender-matched healthy controls were examined by HD-OCT. Mites per follicle and follicles per field of view were counted and compared to skin scrape tests. Results: HD-OCT images depicted mites in the en-face mode as ...

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    22. Topical perfluorodecalin resolves immediate whitening reactions and allows rapid effective multiple pass treatment of tattoos

      Topical perfluorodecalin resolves immediate whitening reactions and allows rapid effective multiple pass treatment of tattoos

      Background and Objective Laser tattoo removal using multiple passes per session, with each pass delivered after spontaneous resolution of whitening, improves tattoo fading in a 60-minute treatment time. Our objective was to evaluate the safety and efficacy of topical perfluorodecalin (PFD) in facilitating rapid effective multiple-pass tattoo removal. Study Design In a randomized, controlled study using Q-switched ruby or Nd:YAG laser, 22 previously treated tattoos were treated with 3 passes using PFD to resolve whitening after each pass (“R0 method”). In previously untreated symmetric tattoos, seven were treated over half of the tattoo with the R20 method, and the ...

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