1. Articles in category: Dermatology

    265-288 of 538 « 1 2 ... 9 10 11 12 13 14 15 ... 21 22 23 »
    1. New Technique For Assessment of Scleroderma Using Vivosight OCT Wins The Abbot Innovation Award At British Society For Rheumatology

      New Technique For Assessment of Scleroderma Using Vivosight OCT Wins The Abbot Innovation Award At British Society For Rheumatology

      A presentation entitled “ Optical coherence tomography validation: a new quantitative imaging biomarker for affected skin in scleroderma ” by Dr Giuseppina Abignano at the Leeds Musculoskeletal Biomedical Research Unit has been awarded the Abbott Innovations Award at the British Society for Rheumatology’s annual conference earlier this month (image below). The research, undertaken at the Leeds Musculoskeletal Biomedical Research Unit, investigates the use of the VivoSight Topical OCT Probe, an innovative skin imaging technology, to assess tell-tale patterns in collagen deposits and vascularisation within the top layers of the skin of scleroderma sufferers. Scleroderma is a chronic multisystem autoimmune disease which ...

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    2. Real-time display with large field of view on fourier domain optical coherence tomography at 1310 nm wavelength for dermatology

      Real-time display with large field of view on fourier domain optical coherence tomography at 1310 nm wavelength for dermatology

      Abstract  A Fourier domain optical coherence tomography (OCT) system with 1310 nm light was demonstrated to study inflammatory human skin and the skin coated with a moisturizer in vivo. By using a graphics processing unit (GPU), the display rate could reach 20 frames/s with 1000 A-scans contained in one image. The field of view (FOV) of the cross-sectional image is 7 mm in the lateral direction and the penetration depth is ∼1 mm in skin. The result shows that, in inflammatory skin, the epidermis became thicker and had a decreased scattering; furthermore, the region of the severe lesion present ...

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    3. Evaluating In Vivo OCT Imaging for Periocular Basal Cell Carcinoma

      Evaluating In Vivo OCT Imaging for Periocular Basal Cell Carcinoma

      Optical coherence tomography (OCT) is an imaging technique which shows the internal structure of living tissue (in vivo). It is safe, quick and painless to perform, and does not damage the tissue in any way. Recent advances in the technology mean that it can now be used to take images of the internal structure of the skin. This is useful because certain conditions, such as skin cancers, alter this structure. At present a suspected skin cancer is identified by taking a sample (a biopsy) which is analysed under the microscope to confirm the diagnosis. The cancer is then excised including ...

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    4. Analysis of the efficiency of hair removal by different optical methods: comparison of Trichoscan, reflectance confocal microscopy, and optical coherence tomography

      Analysis of the efficiency of hair removal by different optical methods: comparison of Trichoscan, reflectance confocal microscopy, and optical coherence tomography

      Noninvasive diagnostic tools, such as Trichoscan®, reflectance confocal microscopy (RCM), and optical coherence tomography (OCT), are efficient methods of hair shaft and growth evaluation. The aim of this study was to carry out a comparative assessment of these three medical procedures by measuring the hair shaft and hair growth after hair removal for a defined period of five days. The application of these techniques was demonstrated by measuring hair growth on the lower leg of six female volunteers. After removal of the hair shaft with a shaving system, the hair follicle infundibula and the length of the growing hairs were ...

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    5. Morphology of basal cell carcinoma in high definition optical coherence tomography: en-face and slice imaging mode, and comparison with histology

      Morphology of basal cell carcinoma in high definition optical coherence tomography: en-face and slice imaging mode, and comparison with histology

      Background  Optical coherence tomography (OCT) allows real-time, in vivo examination of basal cell carcinoma (BCC). A new high definition OCT with high lateral and axial resolution in a horizontal (en-face) and vertical (slice) imaging mode offers additional information in the diagnosis of BCC and may potentially replace invasive diagnostic biopsies. Objectives  To define the characteristic morphologic features of BCC by using high definition optical coherence tomography (HD-OCT) compared to conventional histology. Methods  A total of 22 BCCs were examined preoperatively by HD-OCT in the en-face and slice imaging mode and characteristic features were evaluated in comparison to the histopathological findings ...

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    6. Confocal laser scanning microscopy as a new valuable tool in the diagnosis of onychomycosis – comparison of six diagnostic methods

      Confocal laser scanning microscopy as a new valuable tool in the diagnosis of onychomycosis – comparison of six diagnostic methods

      Onychomycosis is common and can mimic several different nail disorders. Accurate diagnosis is essential to choose the optimum antifungal therapy. The aim of this study was to evaluate the use of confocal laser scanning microscopy (CLSM) and optical coherence tomography (OCT) as new non-invasive diagnostic tools in onychomycosis and to compare them with the established techniques. In a prospective trial, 50 patients with suspected onychomycosis and 10 controls were examined by CLSM and OCT. Parallel KOH preparation, culture, PAS-staining and PCR were performed. PCR showed the highest sensitivity, followed by CLSM, PAS and KOH preparation. OCT offered the second best ...

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    7. Ablation efficiency and relative thermal confinement measurements using wavelengths 1,064, 1,320, and 1,444 nm for laser-assisted lipolysis

      Ablation efficiency and relative thermal confinement measurements using wavelengths 1,064, 1,320, and 1,444 nm for laser-assisted lipolysis

      Abstract  Laser-assisted lipolysis is routinely used for contouring the body and the neck while modifications of the technique have recently been advocated for facial contouring. In this study, wavelength-dependence measurements of laser lipolysis effect were performed using different lasers at 1,064, 1,320, and 1,444 nm wavelengths that are currently used clinically. Fresh porcine skin with fatty tissue was used for the experiments with radiant exposure of 5–8 W with the same parameters (beam diameter = 600 μm, peak power = 200 mJ, and pulse rate = 40 Hz) for 1,064, 1,320 and 1,444 nm laser wavelengths ...

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    8. Noninvasive test methods for epidermal barrier function

      Noninvasive test methods for epidermal barrier function

      New bioengineering techniques provide noninvasive opportunities to evaluate clinically the application of various products on the skin. The skin barrier function and its integrity can be studied by transepidermal water loss, stratum corneum water content, transcutaneous flux of carbon dioxide and oxygen, and transepidermal movement of ions, particularly chloride, potassium, and hydrogen ions. The benefits of noninvasive techniques are due not only to their lack of skin barrier destruction but also to their potential for early detection of any subclinical effects not detected by the naked eyes

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    9. Full-Field Optical Coherence Tomography: A New Technology for 3D High-Resolution Skin Imaging

      Full-Field Optical Coherence Tomography: A New Technology for 3D High-Resolution Skin Imaging

      Background/Aims: Full-field optical coherence tomography (FFOCT) is a new imaging technology that can provide 3D micron-level resolution and is suited for high-resolution imaging of biological tissue. The aim of this study was to evaluate its capacity and potential for imaging human epidermis and dermis and various skin pathologies in ex vivo and in vivo conditions. Methods: Non-fixed and fixed samples of normal and pathological skin and normal in vivo skin were imaged with a FFOCT system and compared to histological slides. Results: The epidermis and adnexae, the collagen bundles of the dermis and the hypodermis could be identified through ...

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    10. Full-field optical coherence tomography: a new technology for 3D high resolution skin imaging

      Full-field optical coherence tomography: a new technology for 3D high resolution skin imaging

      Background/Aims : Full-field optical coherence tomography (FFOCT) is a new imaging technology that can provide 3D micron-level resolution and is suited for high resolution imaging of biological tissue. The aim of this study is to evaluate its capacity and potential for imaging human epidermis and dermis and various skin pathologies in ex- and in-vivo conditions. Methods : Non fixed and fixed samples of normal and pathological skin and normal in-vivo skin were imaged with a FFOCT system and compared to histological slides. Results: The epidermis and adnexae, the collagen bundles of the dermis and the hypodermis could be identified through architectural ...

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    11. Visualization of hair follicles using high-speed optical coherence tomography based on a Fourier domain mode locking laser

      Visualization of hair follicles using high-speed optical coherence tomography based on a Fourier domain mode locking laser

      Abstract  In this study, a swept-source optical coherence tomography (SS-OCT) system with a Fourier domain mode locking (FDML) laser is proposed for a dermatology study. The homemade FDML laser is one kind of frequency-sweeping light source, which can provide output power of >20 mW and an output spectrum of 65 nm in bandwidth centered at 1300 nm, enabling imaging with an axial resolution of 12 μm in the OCT system. To eliminate the forward scans from the laser output and insert the delayed backward scans, a Mach-Zehnder configuration is implemented. Compared with conventional frequency-sweeping light sources, the FDML laser can ...

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    12. Qualitative investigation of fresh human scalp hair with full-field optical coherence tomography

      Qualitative investigation of fresh human scalp hair with full-field optical coherence tomography

      We have investigated depth-resolved cellular structures of unmodified fresh human scalp hairs with ultrahigh-resolution full-field optical coherence tomography (FF-OCT). The Linnik-type white light interference microscope has been home-implemented to observe the micro-internal layers of human hairs in their natural environment. In hair shafts, FF-OCT has qualitatively revealed the cellular hair compartments of cuticle and cortex layers involved in keratin filaments and melanin granules. No significant difference between black and white hair shafts was observed except for absence of only the melanin granules in the white hair, reflecting that the density of the melanin granules directly affects the hair color. Anatomical ...

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    13. High-resolution imaging of microvasculature in human skin in-vivo with optical coherence tomography

      High-resolution imaging of microvasculature in human skin in-vivo with optical coherence tomography

      In this paper, the features of the intensity-based Doppler variance (IBDV) method were analyzed systemically with a flow phantom. The effects of beam scanning density, flow rate and the time interval between neighboring A-lines on the performance of this method were investigated. The IBDV method can be used to quantify the flow rate and its sensitivity can be improved by increasing the time interval between the neighboring A-lines. A higher sensitivity IBDV method that applies the algorithm along the slower scan direction was proposed. In comparison to laser speckle imaging maps of blood flow, we demonstrated the ability of the ...

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    14. Research and System Development on Functional 3D Optical Tomography for Skin Cell Imaging

      Research and System Development on Functional 3D Optical Tomography for Skin Cell Imaging

      The investigators will obtain human skin specimen (sized approximately 1 cm x 1 cm) for dermatological surgical patients in National Taiwan University Hospital, after informed consent was obtained. Human skin keratinocytes, fibroblasts, and melanocytes will be cultured from the human skin specimen. The three dimensional images of these cultured cells will be observed by a ultra-high resolution 3-dimensional optical coherence tomography.

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    15. Optical features for chronological aging and photoaging skin by optical coherence tomography

      Optical features for chronological aging and photoaging skin by optical coherence tomography

      Abstract  The characteristics of skins in different aging processes were obtained by optical coherence tomography (OCT) single scattering model, and their optical parameters were analyzed quantitatively. Significant differences were found in epidermis thickness and attenuation coefficients in chronological aging skins and photonaging skins. These parameters can be served as indicators of skin type as well as the progress of aging. These results are valuable to the study of aging skin, and they could further help to understand the mechanism of aging.

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    16. Michelson Diagnostics announces £607k ($952k) investment to drive sales growth of revolutionary skin cancer scanner

      Michelson Diagnostics announces £607k ($952k) investment to drive sales growth of revolutionary skin cancer scanner

      Michelson Diagnostics (‘Michelson’) has announced an investment of £607k by shareholders Octopus Investments (‘Octopus’), Catapult Venture Managers (‘Catapult’) and individual investors, especially London Business Angels. The investment, which was an extension to the £1.92M investment in October 2011, will be used to further expand sales & support infrastructure in both USA and Europe, as Michelson’s installed base of ‘VivoSight’ skin cancer laser scanners continues to expand. The Company’s first product based on its patented multi‐beam optical coherence tomography (OCT) technology, the VivoSight scanner, is expected to revolutionise the market for the non‐invasive diagnosis and treatment of ...

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    17. Optical characters and texture maps of skin and the aging mechanism by use of multiphoton microscopy and optical coherence tomography

      Optical characters and texture maps of skin and the aging mechanism by use of multiphoton microscopy and optical coherence tomography

      Cutaneous aging is a complicated biological process affecting different constituents of skin, which can be divided into two types: the chronological aging and the photo-aging. The two cutaneous aging processes often co-exist accompanying with each other. The effects are often overlapped including changes in epithelium and dermis. The degeneration of collagen is a major factor in dermal alteration with aging. In this study, multiphoton microscopy (MPM) with its high resolution imaging and optical coherence tomography (OCT) with its depth resolved imaging were used to study the anti-aging dermatology in vivo. It was attempted to make the optical parameter and texture ...

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    18. Update and Clinical Use of Imaging Technologies for Pigmented Lesions of the Skin

      Update and Clinical Use of Imaging Technologies for Pigmented Lesions of the Skin

      The incidence of melanoma is on the rise, and early detection of disease is imperative to reduce mortality. Dermatologists are key players in the early detection of melanoma; however, some clinicians rely on their clinical examination without any additional diagnostic tools to make this important diagnosis. Certain patients, such as atypical nevus patients, have more complicated mole examinations, making the diagnosis of melanoma difficult, whereas some melanomas, such as amelanotic melanomas, can be diagnostically challenging. The goal of the clinician is to detect melanoma with the highest accuracy, while avoiding unnecessary biopsies. Using diagnostic melanoma tools as an adjunct to ...

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    19. Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin

      Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin

      An integrated multimodal optical microscope is demonstrated for high-resolution, structural and functional imaging of engineered and natural skin. This microscope incorporates multiple imaging modalities including optical coherence (OCM), multi-photon (MPM), and fluorescence lifetime imaging microscopy (FLIM), enabling simultaneous visualization of multiple contrast sources and mechanisms from cells and tissues. Spatially co-registered OCM/MPM/FLIM images of multi-layered skin tissues are obtained, which are formed based on complementary information provided by different modalities, i.e., scattering information from OCM, molecular information from MPM, and functional cellular metabolism states from FLIM. Cellular structures in both the dermis and epidermis, especially different morphological ...

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    20. Influence of a pore-forming agent on swelling, network parameters, and permeability of poly(ethylene glycol)-crosslinked poly(methyl vinyl ether-co-maleic acid) hydrogels: Application in transdermal delivery systems

      Influence of a pore-forming agent on swelling, network parameters, and permeability of poly(ethylene glycol)-crosslinked poly(methyl vinyl ether-co-maleic acid) hydrogels: Application in transdermal delivery systems

      We characterized hydrogels, prepared from aqueous blends of poly(methyl vinyl ether-co-maleic acid) (PMVE/MA) and poly(ethylene glycol) (PEG 10,000 Daltons) containing a pore-forming agent (sodium bicarbonate, NaHCO3). Increase in NaHCO3 content increased the equilibrium water content (EWC) and average molecular weight between crosslinks (Mc) of hydrogels. For example, the %EWC was 731, 860, 1109, and 7536% and the Mc was 8.26, 31.64, 30.04, and 3010.00 × 105 g/mol for hydrogels prepared from aqueous blends containing 0, 1, 2, and 5% w/w of NaHCO3, respectively. Increase in NaHCO3 content also resulted in increased ...

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    21. OCT monitoring of cosmetic creams in human skin in vivo

      OCT monitoring of cosmetic creams in human skin in vivo

      Optical coherence tomography (OCT) is a tool currently used for noninvasive diagnosis of human disease as well as for monitoring treatment during or after therapy. In this study, OCT was used to examine penetration and accumulation of cosmetic creams on human hand skin. The samples varied in collagen content with one formulation containing soluble collagen as its primary active ingredient. Collagen is a major connective tissue protein that is essential in maintaining health vitality and strength of many organs. The penetration and localization of collagen in cosmetic creams is thought to be the main determinant of the efficacy of new ...

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    22. Advances in Diagnosing Non-melanoma Skin Cancers

      Advances in Diagnosing Non-melanoma Skin Cancers

      Biopsy remains the gold standard, but newer tools are useful adjuncts. More than 3.5 million skin cancers are diagnosed in more than 2 million patients in the United States each year, 1 and evidence from the American Academy of Dermatology (AAD) suggests that 20% of Americans will develop skin cancer. Basal cell and squamous cell carcinomas (BCC and SCC, respectively) are the two most common forms, accounting for about 96% of non-melanoma skin cancer (NMSC), and are easily treated, 2,3 with the latter more likely to spread to the lymph nodes. Both BCC and SCC are increasingly being ...

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    23. Determining The Extent Of A Structure On Or In The Skin Of A Subject

      Determining The Extent Of A Structure On Or In The Skin Of A Subject

      A method of and determining the extent of a structure (1), such as a non- melanoma skin cancer, in or on the skin of a subject, the method comprising the steps of: placing an index marker (3) on the skin adjacent to the structure (1); positioning an optical coherence tomography device (8) relative to the index marker; using the optical coherence tomography device (8) to image the structure (1) so as to create an image of a cross- section through the skin determining the position of an edge of the structure (1) in the image; and translating that position of ...

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    24. Optical Coherence-domain Imaging of Subcutaneous Human Blood Vessels in vivo

      Optical Coherence-domain Imaging of Subcutaneous Human Blood Vessels in vivo

      Experimental methods of Optical Coherence Tomography (OCT) are applied for two-dimensional mapping of subcutaneous human blood vessels. Structural images of in vivo human finger and human palm macro vessels (0.2-1.0 mm) before and after optical clearing using the modified low power rapid scanning optical delay line are presented. Images are scanned with 12 µm minimum spatial resolution. The described modifications enable to apply low power (0.4-0.5 mW), low noise broadband near infrared light source and to obtain structural images with detection of not only reflected but also multiply scattered coherence-gated photons. The achieved transcutaneous probing depth ...

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