1. Articles in category: Dermatology

    265-288 of 610 « 1 2 ... 9 10 11 12 13 14 15 ... 24 25 26 »
    1. Quantitative evaluation of scattering in optical coherence tomography skin images using the extended Huygens–Fresnel theorem

      Quantitative evaluation of scattering in optical coherence tomography skin images using the extended Huygens–Fresnel theorem

      An optical properties extraction algorithm is developed based on enhanced Huygens–Fresnel light propagation theorem, to extract the scattering coefficient of a specific region in an optical coherence tomography (OCT) image. The aim is to quantitatively analyze the OCT images. The algorithm is evaluated using a set of phantoms with different concentrations of scatterers, designed based on Mie theory. The algorithm is then used to analyze basal cell carcinoma and healthy eyelid tissues, demonstrating distinguishable differences in the scattering coefficient between these tissues. In this study, we have taken advantage of the simplification introduced by the utilization of a dynamic ...

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    2. Mapping of spatial distribution of superficial blood vessels in human skin by double correlation analysis of optical coherence tomography images

      Mapping of spatial distribution of superficial blood vessels in human skin by double correlation analysis of optical coherence tomography images

      2D/3D spatial distribution of superficial blood vessels in human skin in vivo was conducted by double correlation analysis of the swept source Optical Coherence Tomography (OCT) images. An adaptive Wiener filtering technique has been employed to remove background noise and increase the overall quality of the OCT images acquired experimentally. Correlation Mapping and Fourier domain correlation approaches have been subsequently applied to enhance spatial resolution of images of vascular network in human skin. The analysis of images performed on Graphics Processing Units (GPUs) utilizing the recently developed Compute Unified Device Architecture (CUDA) framework.

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    3. Virtual skin biopsy by optical coherence tomography: the first quantitative imaging biomarker for scleroderma

      Virtual skin biopsy by optical coherence tomography: the first quantitative imaging biomarker for scleroderma

      Background Skin involvement is of major prognostic value in systemic sclerosis (SSc) and often the primary outcome in clinical trials. Nevertheless, an objective, validated biomarker of skin fibrosis is lacking. Optical coherence tomography (OCT) is an imaging technology providing high-contrast images with 4 μm resolution, comparable with microscopy (‘virtual biopsy’). The present study evaluated OCT to detect and quantify skin fibrosis in SSc. Methods We performed 458 OCT scans of hands and forearms on 21 SSc patients and 22 healthy controls. We compared the findings with histology from three skin biopsies and by correlation with clinical assessment of the skin ...

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    4. American Academy of Dermatology Session on Optical Coherence Tomography March 4th 2013.

      American Academy of Dermatology Session on Optical Coherence Tomography March 4th 2013.

      Optical coherence tomography (OCT) is a non-invasive imaging device that uses a low intensity laser light to image up to 2mm beneath the skin’s surface. This allows the clinician to get real-time video-rate images of the subsurface structures of the integumentary system without any pre-treatment or gels. OCT has been shown to be a useful diagnostic and monitoring tool. This session will highlight the practical utility of a rapidly effective imaging device in both areas of research as well as a cosmetic and general dermatology practice.

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    5. Skin Cancer Treatment without surgery: Cut-less Dermatology

      Skin Cancer Treatment without surgery: Cut-less Dermatology

      According to the Skin Cancer Foundation, one person dies from skin cancer every hour in the United States — a good reason why everyone should schedule regular skin examinations. But you may ask, how do dermatologists know when a skin growth or mole needs to be removed? In the past, every worrisome skin lesion required a biopsy, meaning a small piece of tissue was surgically removed and sent to a pathology laboratory. If the biopsy showed cancer, additional surgery was needed. Even today, surgical biopsy and removal continues to be the standard of care for skin cancer. Fortunately, we have newer ...

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    6. Studies indicate that VivoSight OCT reliably predicts tumour margins

      Studies indicate that VivoSight OCT reliably predicts tumour margins

      Michelson Diagnostics Press Release - Accurate determination of tumour margins is vital to the successful treatment of skin cancer patients. This is especially the case for patients undergoing Mohs Micrographic Surgery where complete tumour removal may require repeated invasive procedures. Recent studies conducted in two US Healthcare facilities used the VivoSight OCT scanner, manufactured in the UK by Michelson Diagnostics Ltd, to prospectively refine clinically estimated tumour margins prior to Mohs Micrographic Surgery. The first 52 patient study 1 conducted by Professor Dan Seigel (Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, New York) concluded that: “OCT ...

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    7. Optical coherence tomography in dermatology

      Optical coherence tomography in dermatology

      Optical coherence tomography (OCT) is a noninvasive diagnostic method that offers a view into the superficial layers of the skin in vivo in real-time. An infrared broadband light source allows the investigation of skin architecture and changes up to a depth of 1 to 2 mm with a resolution between 15 and 3 μ m, depending on the system used. Thus OCT enables evaluation of skin lesions, especially nonmelanoma skin cancers and inflammatory diseases, quantification of skin changes, visualization of parasitic infestations, and examination of other indications such as the investigation of nails. OCT provides a quick and useful diagnostic imaging ...

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    8. Optical Coherence Tomography–Based Optimization of Mohs Micrographic Surgery of Basal Cell Carcinoma: A Pilot Study

      Optical Coherence Tomography–Based Optimization of Mohs Micrographic Surgery of Basal Cell Carcinoma: A Pilot Study

      Background Optical coherence tomography (OCT) is a noninvasive imaging technique that uses a low-power infrared laser to image up to 2 mm beneath the skin's surface. Objective To test the feasibility and diagnostic value of using in vivo OCT to define excision margins before Mohs micrographic surgery (MMS) of basal cell carcinoma (BCC). Methods Patients with biopsy confirmed BCC undergoing MMS were recruited ( n = 52). Excision margins defined by experienced dermatologists were compared with those of OCT-assessed borders and validated with histologic assessments. Results Forty-one (79%) lesions were clear after one MMS procedure; 11 (21%) lesions required a second ...

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    9. High-definition optical coherence tomography: adapted algorithmic method for pattern analysis of inflammatory skin diseases: a pilot study

      High-definition optical coherence tomography: adapted algorithmic method for pattern analysis of inflammatory skin diseases: a pilot study

      High-definition optical coherence tomography (HD-OCT) is a non-invasive technique for morphological investigation of tissue with cellular resolution filling the imaging gap between reflectance confocal microscopy and conventional optical coherence tomography. The aim of this study is first to correlate dermatopathologic descriptors of inflammatory skin conditions with epidermal alteration to features observed by HD-OCT. Secondly, to assess the discriminative accuracy of common inflammatory reaction patterns with epidermal alteration using HD-OCT by applying Ackerman’s algorithmic method of pattern recognition. The generated HD-OCT images of 160 patients presenting an inflammatory skin disease were analyzed with respect to the following criteria: visualization of ...

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    10. Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study

      Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study

      Background Optical coherence tomography (OCT) is an evolving optical technology that is capable of delivering real-time, high-resolution signatures of tissue. Objectives The purpose of this immediate ex vivo prospective clinical study was: (1) to assess the sensitivity and specificity of OCT on biopsy material in identifying potentially malignant and malignant oral lesions, (2) to determine the inter-observer agreement in the analysis of specific image parameters, and (3) to find out the oral epithelial thickness for different pathology groups. Materials and methods This prospective study involved 125 suspicious oral lesions from 125 patients. The lesions were surgically biopsied and subjected to ...

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    11. Optical Coherence Tomography and Its Role in Mohs Micrographic Surgery: A Case Report

      Optical Coherence Tomography and Its Role in Mohs Micrographic Surgery: A Case Report

      Optical coherence tomography (OCT) is an imaging technology with the potential to provide high-resolution images of the skin non-invasively. With this device, it is possible to identify a host of skin structures including tumors. In this case report, we demonstrate the use of an OCT device in delineating a lateral tumor margin of an ill-defined basal cell carcinoma prior to Mohs micrographic surgery. Following surgery, the OCT images are compared to histologic sections to confirm their accuracy. OCT technology has the potential to be a vital tool for dermatologists and particularly Mohs surgeons in identifying tumor margins and potentially reducing ...

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    12. Microvascular and Fibrosis Imaging Study

      Microvascular and Fibrosis Imaging Study

      In this study we will use Laser Doppler Flowmetry (LDF), Laser Doppler Imaging (LDI), Orthogonal Polarization Spectral Imaging (OPSI), and Optical Coherence Tomography (OCT) to assess differences in microvascular function and density of oral mucosa and skin in subjects with 1) autoimmune diseases with cutaneous involvement: systemic sclerosis (SSc), morphea, dermatomyositis, cutaneous lupus and vasculitis, 2) sickle cell disease (SCD) and 3) chronic graft-versus-host disease (GVHD) compared to healthy subjects. We plan to compare the microvascular changes to overall treatment response in patients with scleroderma and chronic GVHD as assessments will be made before and after the patients start treatment ...

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      Mentions: Duke University
    13. High-Definition Optical Coherence Tomography for the in vivo Detection of Demodex Mites

      High-Definition Optical Coherence Tomography for the in vivo Detection of Demodex Mites

      Demodex mites are involved in different skin diseases and are commonly detected by skin scrape tests or superficial biopsies. A new high-definition optical coherence tomography (HD-OCT) with high lateral and axial resolution in a horizontal (en-face) and vertical (slice) imaging mode might offer the possibility of noninvasive and fast in vivo examination of demodex mites. Methods: Twenty patients with demodex-related skin diseases and 20 age- and gender-matched healthy controls were examined by HD-OCT. Mites per follicle and follicles per field of view were counted and compared to skin scrape tests. Results: HD-OCT images depicted mites in the en-face mode as ...

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    14. Topical perfluorodecalin resolves immediate whitening reactions and allows rapid effective multiple pass treatment of tattoos

      Topical perfluorodecalin resolves immediate whitening reactions and allows rapid effective multiple pass treatment of tattoos

      Background and Objective Laser tattoo removal using multiple passes per session, with each pass delivered after spontaneous resolution of whitening, improves tattoo fading in a 60-minute treatment time. Our objective was to evaluate the safety and efficacy of topical perfluorodecalin (PFD) in facilitating rapid effective multiple-pass tattoo removal. Study Design In a randomized, controlled study using Q-switched ruby or Nd:YAG laser, 22 previously treated tattoos were treated with 3 passes using PFD to resolve whitening after each pass (“R0 method”). In previously untreated symmetric tattoos, seven were treated over half of the tattoo with the R20 method, and the ...

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    15. International imaging meeting highlights growing importance of OCT in skin cancer treatment

      International imaging meeting highlights growing importance of OCT in skin cancer treatment

      Michelson Diagnostics Press Release - Skin cancer is a big problem that is getting worse. Decades of insufficient sun protection are now catching up with an ageing population. While obvious non-melanoma skin cancers (NMSC) can sometimes be dealt with using surgery, widespread field cancerisation where a patient has multiple lesions on say the scalp or face is far more challenging. A holistic approach to assessing and treating the area of field cancerisation is urgently required to cope with the coming “avalanche” of patients. Optical Coherence Tomography (OCT) was highlighted as an increasingly important technology to help Dermatologists diagnose and monitor the ...

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    16. Spectroscopic methods for the photodiagnosis of nonmelanoma skin cancer

      Spectroscopic methods for the photodiagnosis of nonmelanoma skin cancer

      The importance of dermatological noninvasive imaging techniques has increased over the last decades, aiming at diagnosing nonmelanoma skin cancer (NMSC). Technological progress has led to the development of various analytical tools, enabling the in vivo/in vitro examination of lesional human skin with the aim to increase diagnostic accuracy and decrease morbidity and mortality. The structure of the skin layers, their chemical composition, and the distribution of their compounds permits the noninvasive photodiagnosis of skin diseases, such as skin cancers, especially for early stages of malignant tumors. An important role in the dermatological diagnosis and disease monitoring has been shown ...

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    17. Imaging of skin microvessels with optical coherence tomography: potential uses in port wine stains

      Imaging of skin microvessels with optical coherence tomography: potential uses in port wine stains

      The knowledge of vascular structures of port wine stains (PWSs) may be useful to select treatment doses and improve therapeutic efficacy. Biopsies are impractical to implement, therefore, it is necessary to develop non-invasive techniques for morphological evaluation. This study aimed to evaluate the application of a novel optical coherence tomography (OCT) system to characterize the vascular structures of PWSs. First, OCT images were obtained from the skin of healthy rabbit ears and compared with the histopathological images. Second, OCT was used to document the differences between PWS lesions and contralateral normal skin; the size and depth of the vascular structures ...

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    18. Imaging actinic keratosis by high-definition optical coherence tomography. Histomorphologic correlation a pilot study

      Imaging actinic keratosis by high-definition optical coherence tomography. Histomorphologic correlation a pilot study

      Background With the continued development of non-invasive therapies for actinic keratosis such as PDT and immune therapies, the non-invasive diagnosis and monitoring become increasingly relevant. High-definition optical coherence tomography is a high-resolution imaging tool, with micrometer resolution in both transversal and axial directions, enable to visualize individual cells up to a depth of around 570 μm filling the imaging gap between conventional optical coherence tomography and reflectance confocal microscopy. Objective We sought to determine the feasibility of detecting and grading of actinic keratosis by this technique using criteria defined for reflectance confocal microscopy compared to histology. Method In this pilot ...

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    19. Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy

      Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy

      We investigate morphological differences in three-dimensional (3-D) images with cellular resolution between nonmelanoma skin cancer and normal skin using Gabor domain optical coherence microscopy. As a result, we show for the first time cellular optical coherence images of 3-D features differentiating cancerous skin from normal skin. In addition, in vivo volumetric images of normal skin from different anatomic locations are shown and compared.

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    20. Dual instrument for in vivo and ex vivo OCT imaging in an ENT department

      Dual instrument for in vivo and ex vivo OCT imaging in an ENT department

      A dual instrument is assembled to investigate the usefulness of optical coherence tomography (OCT) imaging in an ear, nose and throat (ENT) department. Instrument 1 is dedicated to in vivo laryngeal investigation, based on an endoscope probe head assembled by compounding a miniature transversal flying spot scanning probe with a commercial fiber bundle endoscope. This dual probe head is used to implement a dual channel nasolaryngeal endoscopy-OCT system. The two probe heads are used to provide simultaneously OCT cross section images and en face fiber bundle endoscopic images. Instrument 2 is dedicated to either in vivo imaging of accessible surface ...

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    21. Emerging technologies for the detection of melanoma: achieving better outcomes

      Emerging technologies for the detection of melanoma: achieving better outcomes

      Every year around 2.5–3 million skin lesions are biopsied in the US, and a fraction of these – between 50,000 and 100,000 – are diagnosed as melanoma. Diagnostic instruments that allow early detection of melanoma are the key to improving survival rates and reducing the number of unnecessary biopsies, the associated morbidity, and the costs of care. Advances in technology over the past 2 decades have enabled the development of new, sophisticated test methods, which are currently undergoing laboratory and small-scale clinical testing. This review highlights and compares some of the emerging technologies that hold the promise of ...

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    22. Cryosurgery Treatment of Actinic Keratoses Monitored by Optical Coherence Tomography

      Cryosurgery Treatment of Actinic Keratoses Monitored by Optical Coherence Tomography

      Background: Optical coherence tomography (OCT) is a non-invasive optical imaging technique providing high-resolution images. OCT may be useful as a monitoring tool during treatment of actinic keratoses (AK) and skin cancer. Objective: To examine and describe how OCT skin morphology changes when the tissue is exposed to the effects of cryotherapy. Methods: Normal ex vivo skin and in vivo AK lesions were examined. Cryotherapy was applied and OCT images were acquired at defined time points. OCT morphology was described. Results: Cryotherapy treatment produced an opaque iceball, and freezing depth could not be monitored by OCT. Vesicle formation after cryotherapy could ...

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    23. In vivo assessment of human burn scars through automated quantification of vascularity using optical coherence tomography

      In vivo assessment of human burn scars through automated quantification of vascularity using optical coherence tomography

      In scars arising from burns, objective assessment of vascularity is important in the early identification of pathological scarring, and in the assessment of progression and treatment response. We demonstrate the first clinical assessment and automated quantification of vascularity in cutaneous burn scars of human patients in vivo that uses optical coherence tomography (OCT). Scar microvasculature was delineated in three-dimensional OCT images using speckle decorrelation. The diameter and area density of blood vessels were automatically quantified. A substantial increase was observed in the measured density of vasculature in hypertrophic scar tissues (38%) when compared against normal, unscarred skin (22%). A proliferation ...

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