1. Articles in category: Dermatology

    265-288 of 660 « 1 2 ... 9 10 11 12 13 14 15 ... 26 27 28 »
    1. Optical Coherence Tomography Imaging of Erythroplasia of Queyrat and Treatment with Imiquimod 5% Cream: A Case Report

      Optical Coherence Tomography Imaging of Erythroplasia of Queyrat and Treatment with Imiquimod 5% Cream: A Case Report

      Lesion biopsy is currently used to diagnose erythroplasia of Queyrat (EQ), a rare squamous cell carcinoma in situ of the glans penis, or to determine whether the cancer is invasive, although the results only apply to the area from which the biopsy is taken. In this case report, we illustrate for the first time the use of optical coherence tomography (OCT) in imaging the entire lesion in a patient with EQ. The results confirmed that the patient had in situ rather than invasive carcinoma. Consequently, non-invasive treatment with imiquimod 5%, a topical immunomodulator with antitumour and antiviral properties, was initiated ...

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    2. In vivo determination of epidermal thickness using high-definition optical coherence tomography

      In vivo determination of epidermal thickness using high-definition optical coherence tomography

      With great interest, we read the article of Mogensen and co-workers, which was published in this journal. 1 They studied 11 actinic keratoses and 23 basal cell carcinomas (< 2 mm thickness) using conventional optical coherence tomography (OCT, 20 μm lateral resolution) and 20-MHz ultrasound. OCT and 20-MHz ultrasound were compared with routine histology. The authors concluded that systematic comparison between mean OCT and 20-MHz ultrasound lesion thickness demonstrated that OCT is more accurate and less biased than 20-MHz ultrasound, even though both methods tended to overestimate the thickness of the lesion. Recently, high-definition OCT (HD-OCT) scanners have been developed providing ...

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      Mentions: Thilo Gambichler
    3. Optical coherence tomography (OCT) of collagen in normal skin and skin fibrosis

      Optical coherence tomography (OCT) of collagen in normal skin and skin fibrosis

      Optical coherence tomography (OCT) is a non-invasive imaging modality that is transforming clinical diagnosis in dermatology and other medical fields. OCT provides a cross-sectional evaluation of the epidermis and dermis and allows in vivo imaging of skin collagen. Upregulated collagen content is a key feature of fibrotic skin diseases. These diseases are often managed by the practitioner’s subjective assessment of disease severity and response to therapies. The purpose of this review is to provide an overview of the principles of OCT and present available evidence on the ability of OCT to image skin collagen in vivo for the diagnosis ...

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      Mentions: UC Davis
    4. Optical coherence tomography imaging of non-melanoma skin cancer undergoing imiquimod therapy

      Optical coherence tomography imaging of non-melanoma skin cancer undergoing imiquimod therapy

      Purpose To explore the application of optical coherence tomography (OCT) imaging of basal cell carcinomas (BCC) and actinic keratosis (AK) before, during and after imiquimod treatment and the ability of OCT to predict treatment outcome. Methods The study subjects were 20 patients with biopsy-verified BCC (9) or AK (11). Patients were OCT-scanned before, after 1 and 4 weeks of imiquimod treatment and after 3 months. Lesions were identified clinically and with OCT. Thickness and morphology of the lesions were recorded at each visit. Any remaining lesions were biopsied at follow-up. Results Complete data sets were available for 16 patients (8 ...

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    5. Optical coherence tomography monitoring of enhanced skin optical clearing in rats in vivo

      Optical coherence tomography monitoring of enhanced skin optical clearing in rats in vivo

      A comparative study of physical, chemical, and combined enhancement of transdermal transport of optical clearing agents (OCAs) is presented. As a physical enhancer of diffusivity, ultrasound (US) with a frequency 1 MHz and a power 1.1 W in the continuous mode was used, and dimethyl sulfoxide (DMSO) was used as a chemical enhancer. OCA (glycerol and polyethylene glycol-400 in equal proportion) was topically applied to the rat skin in vivo as alone or as together with the enhancers. Monitoring of skin optical clearing was implemented using an optical coherence tomography. The results have shown that the attenuation coefficient of ...

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    6. In situ histology of mice skin through transfer learning of tissue energy interaction in optical coherence tomography

      In situ histology of mice skin through transfer learning of tissue energy interaction in optical coherence tomography

      Tissue characterization method in optical coherence tomography (OCT) for in situ histology of soft tissues is presented and demonstrated for mice skin. OCT allows direct noninvasive visualization of subsurface anatomy. It is currently used for in situ investigation of lesions in skin, vessels, retinal layers, oral, and bronchial cavitities. Although OCT images present high resolution information about tissue morphology, reporting requires a reader experienced in interpretation of the images, viz., identification of anatomical layers and structures constituting the organ based on OCT speckle appearance. Our approach characterizes tissues through transfer learning of tissue energy interaction statistical physics models of ballistic ...

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    7. Optical coherence tomography imaging of non‐melanoma skin cancer undergoing imiquimod therapy

      Optical coherence tomography imaging of non‐melanoma skin cancer undergoing imiquimod therapy

      Purpose To explore the application of optical coherence tomography (OCT) imaging of basal cell carcinomas (BCC) and actinic keratosis (AK) before, during and after imiquimod treatment and the ability of OCT to predict treatment outcome. Methods The study subjects were 20 patients with biopsy-verified BCC (9) or AK (11). Patients were OCT-scanned before, after 1 and 4 weeks of imiquimod treatment and after 3 months. Lesions were identified clinically and with OCT. Thickness and morphology of the lesions were recorded at each visit. Any remaining lesions were biopsied at follow-up. Results Complete data sets were available for 16 patients (8 ...

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    8. Physical Sciences Incorporated Receives NIH Grant for Combined RCM and PS-OCT for Skin Cancer Imaging

      Physical Sciences Incorporated Receives NIH Grant for Combined RCM and PS-OCT for Skin Cancer Imaging

      Physical Sciences Incorporated Received a 2013 NIH Grant for $123,797 Combined RCM and PS-OCT for Skin Cancer Imaging. The principal investigator is Mircea Mujat. The program began in 2012 and ends in 2014. Below is a summary of the work. Physical Sciences, Inc. (PSI), in collaboration with Memorial Sloan Kettering Cancer Center (MSKCC) and Lucid, Inc., proposes to investigate the use of combined reflectance confocal microscopy- polarization sensitive optical coherence tomography (RCM-PSOCT) for in vivo diagnosis of skin cancers. Both RCM and OCT are powerful technologies with proven success in human skin imaging. While RCM provides en face images ...

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    9. Potential Use of Optical Coherence Tomography and High-Frequency Ultrasound for the Assessment of Nail Disease in Psoriasis and Psoriatic Arthritis

      Potential Use of Optical Coherence Tomography and High-Frequency Ultrasound for the Assessment of Nail Disease in Psoriasis and Psoriatic Arthritis

      Background: Psoriatic nail disease is increasingly recognised to be of major clinical and research relevance. Clinical assessment remains the current gold standard for its evaluation. Objective: We compared optical coherence tomography (OCT) and ultrasound (US) for nail disease assessment in psoriatic disease. Methods: 18 patients with at least one involved nail and 12 healthy controls were scanned using OCT; psoriatic patients also had an US scan (using a linear probe at 9-14 MHz). Nail and contour abnormalities were documented. Clinical onychopathy was scored independently using the modified Nail Psoriasis Severity Index. Results: Among 180 nails, 67.8% had clinical findings ...

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    10. Skin Cancer A Practical Approach (Textbook)

      Skin Cancer A Practical Approach (Textbook)

      Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease. OCT is an interferometric technique that detects reflected and backscattered light from tissue and is often described as the optical analogue to ultrasound. The inherent safety of the technology allows for in vivo use of OCT in patients. The main strength of OCT is the depth resolution. In dermatology, most OCT research has turned on non-melanoma skin cancer (NMSC) and non-invasive monitoring of morphological changes in a number of skin diseases based on pattern recognition ...

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    11. SKINTELL from Agfa HealthCare in the picture at the International Summer Academy (ISA) in Munich

      SKINTELL from Agfa HealthCare in the picture at the International Summer Academy (ISA) in Munich

      Thanks to Dr. Tanja Maier from the Ludwig Maximilian University (LMU) in Munich a dedicated high-quality workshop took place around Agfa HealthCare’s me first technology, called High-Definition Optical Coherence Tomography (HD-OCT), The lecture from Dr. Maier was focused on non-melanoma skin cancers. A SKINTELL demonstration was given and all kinds of images from various skin diseases were discussed. The attendees took the opportunity to use this non-invasive technology and to take images themselves. Our booth received great interest and in this regard many demonstrations were given to dermatologists and young, upcoming dermatologists. During this congress that took place from ...

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    12. In vivo and ex vivo approaches to studying the biomechanical properties of healing wounds in rat skin

      In vivo and ex vivo approaches to studying the biomechanical properties of healing wounds in rat skin

      Background: An evaluation of wound mechanics is crucial in reflecting the wound healing status. The present study examined the biomechanical properties of healing rat skin wounds in vivo and ex vivo. Method of approach: Thirty male Sprague-Dawley rats, each with a 6 mm full-thickness circular punch biopsied wound at both posterior hind limbs were used. The mechanical stiffness at both the central and margins of the wound was measured repeatedly in five rats over the same wound sites to monitor the longitudinal changes over time of before wounding, and on Days 0, 3, 7, 10, 14, and 21 after wounding ...

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    13. Assessment of psoriatic plaque in vivo with correlation mapping optical coherence tomography

      Assessment of psoriatic plaque in vivo with correlation mapping optical coherence tomography

      Background/Purpose Vascular abnormalities play an acute role in the pathogenesis of psoriasis. In order to characterize vascular involvement in psoriasis and its regular clinical assessment in vivo , non-invasive high speed imaging with high resolution and high sensitivity is needed. Methods The correlation mapping optical coherence tomography (cmOCT) technique was used for in vivo microcirculation imaging of human forearm under normal and psoriatic conditions. The cmOCT technique developed by our group uses dense scanning OCT image acquisition and post-processing software based on correlation statistics. The frequency domain OCT system was used for imaging which acquires a 3D volume of 1024 ...

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    14. High-definition optical coherence tomography imaging of melanocytic lesions: a pilot study

      High-definition optical coherence tomography imaging of melanocytic lesions: a pilot study

      High-definition optical coherence tomography (HD-OCT) is a non-invasive in vivo imaging technique with cellular resolution based on the principle of conventional optical coherence tomography. The objective of this study was to evaluate HD-OCT for its ability to identify architectural patterns and cytologic features of melanocytic lesions. All lesions were examined by one observer clinically and using dermoscopy. Cross-sectional HD-OCT images were compared with histopathology. En face HD-OCT images were compared with reflectance confocal microscopy (RCM). Twenty-six melanocytic lesions of 26 patients were imaged. Identification of architectural patterns in cross-sectional mode and cytologic features of pigmented cells in the epidermis, dermo-epidermal ...

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    15. Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus

      Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus

      Background/purpose The present study aimed to investigate the influence of topical corticosteroid therapy and tacrolimus on morphological indices of different skin phototypes and to optimize topical therapy using the OCT technique. Methods Twenty healthy volunteers aging from 20 to 30 (14 men and 6 women) took part in the study: 10 persons with skin phototype I, II and 10 persons with skin phototype V, VI. Morphological state of the skin was assessed before and during application of topical steroids of different strength and calciumneurin inhibitors for 49 days. Morphological state was studied in vivo using the optical coherence tomograph ...

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    16. Optical coherence tomography: What is optical coherence tomography?

      Optical coherence tomography:  What is optical coherence tomography?

      Optical coherence tomography (OCT) is a non-invasive optical imaging technique that uses low-power infrared laser light to image up to 2 mm beneath the skin surface. The clinician can obtain real-time images of the architecture of the skin without pretreatment or gels. OCT has been shown to be a useful diagnostic tool in diagnosing early stage skin cancer [1]. What lies beneath the skin surface can be seen in vivo, without the need for skin biopsy [2]. Studies have compared OCT findings with histopathology, establishing the OCT characteristics of actinic keratoses , in-situ squamous cell carcinoma (SCC), and basal cell carcinoma ...

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    17. Optical Coherence Tomography for presurgical margin assessment of non‐melanoma skin cancer‐a practical approach

      Optical Coherence Tomography for presurgical margin assessment of non‐melanoma skin cancer‐a practical approach

      Background In the clinical setting, OCT is applicable for the non-invasive diagnosis of skin cancer and may in particular be used for margin definition prior to excision. In this regard, OCT may improve the success rate of removing tumor lesions more effectively, preventing repetitive excision, which may subsequently result in smaller excisions. Objective In this study we have aimed to evaluate the applicability of OCT for in-vivo presurgical margin assessment of non-melanocytic skin tumors (NMSC) and to describe the feasibility of different scanning techniques. Material and methods A total number of 18 patients planned for excision of lesions suspicious of ...

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    18. Dual-imaging system for burn depth diagnosis

      Dual-imaging system for burn depth diagnosis

      Currently, determination of burn depth and healing outcomes has been limited to subjective assessment or a single modality, e.g., laser Doppler imaging. Such measures have proven less than ideal. Recent developments in other non-contact technologies such as optical coherence tomography (OCT) and pulse speckle imaging (PSI) offer the promise that an intelligent fusion of information across these modalities can improve visualization of burn regions thereby increasing the sensitivity of the diagnosis. In this work, we combined OCT and PSI images to classify the degree of burn (superficial, partial-thickness and full-thickness burns). Algorithms were developed to integrate and visualize skin ...

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    19. Confocal laser scanning microscopy and optical coherence tomography for the evaluation of the kinetics and quantification of wound healing after fractional laser therapy

      Confocal laser scanning microscopy and optical coherence tomography for the evaluation of the kinetics and quantification of wound healing after fractional laser therapy

      Background Information on the course of wound healing after fractional carbon-dioxide laser therapy has so far been gathered by histopathology. Confocal laser scanning microscopy (CLSM) and optical coherence tomography (OCT) allow the visualization of the upper layers of the skin in vivo over time. Objective The aim of this study was to determine whether CLSM and OCT can be used to quantify the kinetics of the dynamic wound-healing process. Methods Twenty healthy probands were treated with fractional carbon-dioxide laser with 8- and 16-W laser power, respectively. Optical follow-ups using CLSM and OCT were performed right after laser application and during ...

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    20. Evaluation of optical coherence tomography as a non-invasive diagnostic tool in cutaneous wound healing

      Evaluation of optical coherence tomography as a non-invasive diagnostic tool in cutaneous wound healing

      Background The monitoring of wound-healing processes is indispensable for the therapeutic effectiveness and improved care of chronic wounds. Histological sections provide the best morphological assessment of wound recovery, but cause further tissue destruction and increase the risk of infection. Therefore, it is reasonable to apply a diagnostic tool that allows a non-invasive and reliable observation of morphological changes in wound healing. Methods Optical coherence tomography (OCT) is an imaging technique for in vivo evaluation of skin diseases with a resolution close to histopathology. The aim of this study was to investigate whether OCT is suited to display the phases of ...

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    21. PhD Studentship in High Speed 3D Studies of the Biomechanics of Skin Friction at University of Sheffield

      PhD Studentship in High Speed 3D Studies of the Biomechanics of Skin Friction at University of Sheffield

      This PhD will support a recently funded EPSRC project which is being carried out in the Departments of Mechanical Engineering and Materials Science and Engineering, centred on improving our understanding of skin friction. Skin plays many vital roles in the health of the body. One area that has received less attention than others is its function in providing required levels of friction. Factors determining skin friction are relevant to areas such as medicine, sports science, rehabilition engineering, cosmetics and consumer lifestyle. Insufficient friction contributes to difficulties experienced by the elderly in gripping objects. Excessive friction can lead to discomfort, chaffing ...

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    22. Acute skin lesions following psoralen plus ultraviolet A radiation investigated by optical coherence tomography

      Acute skin lesions following psoralen plus ultraviolet A radiation investigated by optical coherence tomography

      Psoralen plus ultraviolet A radiation (PUVA) therapy is a very important clinical treatment of skin diseases such as vitiligo and psoriasis, but associated with an increased risk of skin photodamage, especially photoaging. In this work, optical coherence tomography (OCT), a novel non-invasive imaging technology, was introduced to investigate in vivo the photodamage induced by PUVA qualitatively and quantitatively. Balb/c mouse dorsal skin was treated with 8-methoxypsoralen (8-MOP), and then exposed to UVA radiation. OCT images of the tissues were obtained by an OCT system with a 1310 nm central wavelength. Skin thickness and the attenuation coefficient were extracted from ...

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    23. Michelson Diagnostics wins Regulatory Approval for VivoSight OCT Scanner in Australia

      Michelson Diagnostics wins Regulatory Approval for VivoSight OCT Scanner in Australia

      Michelson Diagnostics Press release: Michelson Diagnostics the UK based medical device company has been given regulatory approval by the Therapeutics Goods Administration (TGA) in Australia to start selling its market leading VivoSight OCT Scanner. Australia has the highest incidence of skin cancer in the world and the number of people needing treatment continues to grow. The Australian Institute of Health and Welfare and Cancer Australia estimates there were 430,000 new cases of Non-Melanoma Skin Cancer diagnosed in 2008. This is approximately four-fold higher than the number of new cases diagnosed in the UK. In a recent position statement, the ...

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    24. In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography

      In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography

      Background: Sarcoptes scabiei can be visualized with different imaging tools. Optical coherence tomography (OCT) may have the potential to describe the changes in skin morphology due to scabies infestation and visualize the parasite. Methods: Five patients from the Departments of Dermatology, Augsburg, Germany, and Roskilde, Denmark, were OCT scanned (VivoSight®; Michelson Diagnostics Ltd., UK). Mites were identified by epiluminescence and light microscopy to confirm the diagnosis. Results: OCT identified S. scabiei mites in all patients in vivo. Mites and burrows were visualized, and some detail on burrow content was provided. Conclusion: OCT can visualize S. scabiei mites in vivo, suggesting ...

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