1. Articles in category: Dermatology

    265-288 of 478 « 1 2 ... 9 10 11 12 13 14 15 ... 18 19 20 »
    1. Optical coherence tomography in dermatology: technical and clinical aspects

      Optical coherence tomography in dermatology: technical and clinical aspects

      Abstract  Optical coherence tomography (OCT), a fairly new non-invasive optical real-time imaging modality, is an emergent in vivo technique, based on the interference (Michelson interferometry) of infrared radiation and living tissues, that allows high-resolution, 2- or 3-dimensional, cross-sectional visualisation of microstructural morphology of tissues. OCT provides depth-resolved images of tissues with resolution up to a few micrometers and depth up to several millimetres depending on tissue type. The investigations using OCT to assess skin structure in clinical settings started in the past decade and consequently proved that this imaging method is useful in visualizing subsurface structures of normal skin, including ...

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    2. High-speed functional OCT with self-reconstructive Bessel illumination at 1300nm

      High-speed functional OCT with self-reconstructive Bessel illumination at 1300nm
      Cedric Blatter, Branislav Grajciar, and Christoph M. Eigenwillig et al. We present a Bessel beam illumination FDOCT setup with FDML buffered swept source at 1300nm. An extended focus is achieved due to the Bessel beam that preserves its lateral extend over a large depth range. Decoupling the illumination from the Gaussian detection improves the sensitivity as compared t ... [Proc. SPIE 8091, 809104 (2011)] published Thu Jun 09, 2011.
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    3. Structural analysis of artificial skin equivalents

      Structural analysis of artificial skin equivalents

      Artificial skin equivalents ASEs based on primary fibroblasts and keratinocytes show a high batch variance in their structural and morphological characteristics. Due to biological fluctuations and variable donor age, the growth processes of 3D tissue structure show a non constant quality. Since theses ASEs are used as testing system for chemicals, pharmaceuticals or cosmetics it is of major interest to know detailed and significant characteristics about each individual ASE. Until now, the microscopic analysis process is based on the destructive preparation of histologies allowing only the characterization on a random basis. In this study we present analytical methods to characterise ...

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    4. Angular high-speed massively parallel detection spectral-domain optical coherence tomography for speckle reduction

      Angular high-speed massively parallel detection spectral-domain optical coherence tomography for speckle reduction
      We demonstrate speckle reduction based on angular compounding using parallel-detection spectral-domain optical coherence tomography (OCT). An ultrahigh-speed two-dimensional complementary metal-oxide semiconductor camera acquired angular and spectral interference fringes (128×1024 pixels) simultaneously at 15,000 frames/s for a single lateral point. A signal-to-noise ratio improvement of 8 dB was achieved for imaging human skin in vivo by averaging 121 angle-resolved OCT images.
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    5. How histological features of basal cell carcinomas influence image quality in optical coherence tomography

      How histological features of basal cell carcinomas influence image quality in optical coherence tomography
      Optical coherence tomography (OCT) has the potential to diagnose and measure the depth of nonmelanoma skin cancer (NMSC) in skin, but some lesions appear blurred in OCT images. The aim of this study is to identify histological characteristics of basal cell carcinomas (BCC) that correlate with good quality OCT images of the same lesions. A total of 34 patients with BCC were OCT scanned. The influence of histology parameters (e.g. inflammation, sun damage of skin, carcinoma cell size) on OCT image quality was studied by comparing 15 BCC lesions easily identified compared to 19 BCC lesions that produced only ...
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    6. Optical Coherence Tomography monitoring of PDT effect on Basal Cell Carcinomas wins gold

      Optical Coherence Tomography monitoring of PDT effect on Basal Cell Carcinomas wins gold

      Michelson Diagnostics Press Release - A presentation by the Dermatology Departments at Roskilde & Gentofte Hospitals, Copenhagen which documents how Optical Coherence Tomography (OCT) can monitor the effectiveness of PDT treatment on superficial Basal Cell Carcinomas (BCCs) has been awarded gold by the 22nd World Congress of Dermatology. The investigation was carried out using the Michelson Diagnostics’ VivoSight OCT Scanner.

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    7. Strategies for Assessing the Degree of Photodamage to Skin: A Systematic Review of the Literature

      Strategies for Assessing the Degree of Photodamage to Skin: A Systematic Review of the Literature
      As our understanding of the role of ultraviolet (UV) radiation exposure in causing skin cancer continues to be enhanced, it is important that clinicians and researchers are familiar with the various methods for assessing photodamage to skin. This paper provides a systematic review of the published literature on invasive and non-invasive methods used to quantify lifetime UV exposure (‘photoageing’). Clinical examination, histopathology, immunohistochemistry, skin surface topography and ultrasound, in addition to newer technologies such as reflectance confocal microscopy (RCM), optical coherence tomography (OCT) and multiphoton tomography (MPT), were reviewed. It is concluded that histopathological solar elastosis alone should not be ...
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    8. Dynamic analysis for mental sweating of a group of eccrin sweat glands on a human fingertip by optical coherence tomography

      Dynamic analysis for mental sweating of a group of eccrin sweat glands on a human fingertip by optical coherence tomography
      OCT is highly potential for in vivo observation of human sweating dynamics which affects activity of the sympathetic nerve. In this paper, we demonstrate dynamic OCT analysis of mental sweating of a group of eccrin sweat glands. The sweating dynamics is tracked simultaneously for nineteen sweat glands by time-sequential piled-up en-face OCT images with the frame spacing of 3.3 sec. Strong non-uniformity is observed in mental sweating where the amount of excess sweat is different for each sweat gland although the sweat glands are adjacent to each other. The non-uniformity should be necessary to adjust as precisely the total ...
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      Mentions: Osaka University
    9. Quantitative principal component model for skin chromophore mapping using multi-spectral images and spatial priors

      Quantitative principal component model for skin chromophore mapping using multi-spectral images and spatial priors
      We describe a novel reconstruction algorithm based on Principal Component Analysis (PCA) applied to multi-spectral imaging data. Using numerical phantoms, based on a two layered skin model developed previously, we found analytical expressions, which convert qualitative PCA results into quantitative blood volume and oxygenation values, assuming the epidermal thickness to be known. We also evaluate the limits of accuracy of this method when the value of the epidermal thickness is not known. We show that blood volume can reliably be extracted (less than 6% error) even if the assumed thickness deviates 0.04mm from the actual value, whereas the error ...
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    10. Michelson has its sights set on US for skin cancer scanner

      Michelson has its sights set on US for skin cancer scanner
      Kent laser company with skin cancer detection breakthrough eyes US opportunity – but it needs to make sure the effectiveness of the scanner it has produced doesn’t leave its customers out of pocket. Launching a disruptive product in the US health care market despite limited resources and little track record at home Kent-based Michelson Diagnostics believes it has invented a laser scanner that offers a breakthrough in the diagnosis and treatment of skin cancer. Venture capitalists and private investors agree and have backed the business with £4.5m. More importantly, the scanner – called VivoSight – has been used by clinicians in ...
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    11. Expert views on Michelson Diagnostics

      Expert views on Michelson Diagnostics
      Is a small Kent based engineering business right to ignore the UK market for its skin cancer detection scanner? Health care experts and entrepreneurs offer their views. Gerry George, AIM research innovation fellow and professor of innovation and entrepreneurship, Imperial College London It’s appropriate to see the business behind a product like VivoSight developing its beachhead entry strategy in the US market, which is the largest consumer market for their technology. The issues to be careful about are threefold. First, for a start-up, winning a small share of a large market is much more difficult than winning a large ...
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    12. Elastic properties of soft tissue-mimicking phantoms assessed by combined use of laser ultrasonics and low coherence interferometry

      Elastic properties of soft tissue-mimicking phantoms assessed by combined use of laser ultrasonics and low coherence interferometry
      Advances in the field of laser ultrasonics have opened up new possibilities in medical applications. This paper evaluates this technique as a method that would allow for rapid characterization of the elastic properties of soft biological tissue. In doing so, we propose a novel approach that utilizes a low coherence interferometer to detect the laser-induced surface acoustic waves (SAW) from the tissue-mimicking phantoms. A Nd:YAG focused laser line-source is applied to one- and two-layer tissue-mimicking agar-agar phantoms, and the generated SAW signals are detected by a time domain low coherence interferometry system. SAW phase velocity dispersion curves are calculated ...
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    13. Breakthrough 3-D optical imaging possible in vivo

      Breakthrough 3-D optical imaging possible in vivo
      National report — A series of technological innovations has led to near-real-time, in vivo, three-dimensional optical imaging of skin up to a depth of 1 mm – with potentially a depth of up to 2 mm with clearing methods. The resolution is approaching that of histology biopsy. Initial use is likely to be in a research setting; broad clinical use will require both validation and the marketing of a device that is economically competitive with biopsy. This breakthrough in optical coherence tomography (OCT) imaging was achieved by a team at the University of Rochester Institute of Optics. "We leveraged emerging technology that ...
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    14. Optical coherence tomography-guided photodynamic therapy for skin cancer: Case series

      Optical coherence tomography-guided photodynamic therapy for skin cancer: Case series
      Background: Guiding and monitoring treatment during and after photodynamic therapy (PDT) of skin cancer is often difficult. Objectives: We investigated the applicability of in vivo optical coherence tomography (OCT) in guiding and monitoring PDT in patients with skin cancer.
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    15. Qualitative optical coherence tomography for normal and pathologic skin lesions

      Qualitative optical coherence tomography for normal and pathologic skin lesions
      The pre-clinical application of optical coherence tomography (OCT) on ex vivo skin lesions has validated this tool structurally and metrically. However, knowledge of in vivo normal and pathological skin architectural and morphological properties would be of significant interest in dermatological practice.
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    16. Diagnostic Devices Market to Grow 7.3% Annually Through 2015

      Diagnostic Devices Market to Grow 7.3% Annually Through 2015
      ROCKVILLE, MD--(Marketwire - Apr 19, 2011) - MarketResearch.com has announced the addition of MarketsandMarkets's new report "Worldwide Dermatology Devices Market (2010 - 2015)," to their collection of Therapeutic Area market reports. For more information, visit http://www.marketresearch.com/product/display.asp?ProductID=6221051 The dermatology devices studied and segmented in this report are as per their usage in the diagnosis and treatment of skin related disorders such as skin cancer (melanoma and non-melanoma), psoriasis, acne, scars, and others. The diagnostic devices analyzed are dermatoscopes, microscopes, imaging techniques such as MRI, CT and Optical Coherence Tomography (OCT) scanners. The total ...
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    17. Application of optical methods to characterize textile materials and their influence on the human skin

      Application of optical methods to characterize textile materials and their influence on the human skin

      The skin is not only the largest organ of the human body, but it is also a barrier to the environment. The major part of the human skin is in constant contact with textile materials. The objective of this study was to characterize textile materials and to investigate their influence on the skin properties. For this purpose, two different textile materials (polyamide and polyester) were objectively characterized by optical coherence tomography and surface structure 3D-profilometry. In addition, subjective textile properties like haptic sensation and stiffness, as tactile characteristics felt by volunteers, were analyzed. The objective textile characteristics and subjective parameters ...

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    18. OCT mapping tracks skin cancer during PDT

      OCT mapping tracks skin cancer during PDT
      OCT mapping tracks skin cancer during PDT A case study at University College Hospital London has demonstrated the successful use of optical coherence tomography (OCT) for in vivo mapping of non-melanoma skin cancer during photodynamic therapy (PDT). PDT provides a non-invasive alterative to surgical excision for non-melanoma skin cancers. But as no tissue is removed for analysis, it can be difficult to ensure all the tumour is treated. This work showed that the use of OCT (the VivoSight from Michelson Diagnostics) to image skin before, during and after PDT, could solve this problem (Photodiagnosis and Photodynamic Therapy 8 49).
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    19. In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT)

      In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT)
      Correlation mapping optical coherence tomography (cmOCT) is a recently proposed technique that extends the capabilities of OCT to enable mapping of vasculature networks. The technique is achieved as a processing step on OCT intensity images that does not require any modification to existing OCT hardware. In this paper we apply the cmOCT processing technique to in vivo human imaging of the volar forearm. We illustrate that cmOCT can produce maps of the microcirculation that clearly follow the accepted anatomical structure. We demonstrate that the technique can extract parameters such as capillary density and vessel diameter. These parameters are key clinical ...
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    20. The global dermatology devices market is expected to grow at a CAGR of 7.3% from 2010 to 2015

      The global dermatology devices market is expected to grow at a CAGR of 7.3% from 2010 to 2015
      Worldwide Dermatology Devices Market (2010 - 2015) - The dermatology devices studied and segmented in this report are as per their usage in the diagnosis and treatment of skin related disorders such as skin cancer (melanoma and non-melanoma), psoriasis, acne, scars, and others. The diagnostic devices analyzed are dermatoscopes, microscopes, imaging techniques such as MRI, CT and Optical Coherence Tomography (OCT) scanners. The total market for diagnostic devices was estimated to be $175 million in 2010, and is expected to grow at a CAGR of 7.3% from 2010 to 2015.
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    21. Dermal reflectivity determined by optical coherence tomography is an indicator of epidermal hyperplasia and dermal edema within inflamed skin

      Dermal reflectivity determined by optical coherence tomography is an indicator of epidermal hyperplasia and dermal edema within inflamed skin
      Psoriasis is a common inflammatory skin disease resulting from genetic and environmental alterations of cutaneous immune responses. While numerous therapeutic targets involved in the immunopathogenesis of psoriasis have been identified, the in vivo dynamics of inflammation in psoriasis remain unclear. We undertook in vivo time course focus-tracked optical coherence tomography (OCT) imaging to noninvasively document cutaneous alterations in mouse skin treated topically with Imiquimod (IMQ), an established model of a psoriasis-like disease. Quantitative appraisal of dermal architectural changes was achieved through a two parameter fit of OCT axial scans in the dermis of the form A(x, y, z) = ρ ...
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    22. First published application of Optical Coherence Tomography for in vivo mapping of non-melanoma skin cancer

      First published application of Optical Coherence Tomography for in vivo mapping of non-melanoma skin cancer
      Michelson Diagnostics Press Release: A case study performed at University College Hospital London documenting the successful use of Michelson Diagnostics’ VivoSight OCT scanner for in vivo mapping of non-melanoma skin cancer, has been published in the March 2011 issue of Photodiagnosis and Photodynamic Therapy1.   The key benefit of Photodynamic Therapy (PDT) of non-melanoma skin cancers over conventional surgical excision is that it is non-invasive and therefore avoids surgery scars. This is a major advantage for the patient, because this type of skin cancer frequently occurs on the face, where disfiguring scars are highly undesirable. However, because no tissue is removed ...
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    23. In vivo three-dimensional optical coherence elastography

      In vivo three-dimensional optical coherence elastography
      Abstract: We present the first three-dimensional (3D) data sets recorded using optical coherence elastography (OCE). Uni-axial strain rate was measured on human skin in vivo using a spectral-domain optical coherence tomography (OCT) system providing >450 times higher line rate than previously reported for in vivo OCE imaging. Mechanical excitation was applied at a frequency of 125 Hz using a ring actuator sample arm with, for the first time in OCE measurements, a controlled static preload. We performed 3D-OCE, processed in 2D and displayed in 3D, on normal and hydrated skin and observed a more elastic response of the stratum corneum ...
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    24. Automatic measurement of epidermal thickness from optical coherence tomography images using a new algorithm

      Automatic measurement of epidermal thickness from optical coherence tomography images using a new algorithm
      Background/purpose: Optical coherence tomography (OCT) is an imaging system that enables in vivo epidermal thickness (ET) measurement. In order to use OCT in large-scale clinical studies, automatic algorithm detection of the dermo-epidermal junction (DEJ) is needed. This may be difficult due to image noise from optical speckle, which requires specific image treatment procedures to reduce this. In the present work, a description of the position of the DEJ is given, and an algorithm for boundary detection is presented. Methods: Twenty-nine images were taken from the skin of normal healthy subjects, from five different body sites. Seven expert assessors were ...
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