1. Articles in category: Dermatology

    265-288 of 579 « 1 2 ... 9 10 11 12 13 14 15 ... 23 24 25 »
    1. OCT Images Blood Vessels that Feed Cancer

      OCT Images Blood Vessels that Feed Cancer

      An optical coherence tomography (OCT) technique that noninvasively maps the network of tiny blood vessels in the epidermis could soon help doctors better diagnose, monitor and treat skin cancer. Scientists at Medical University Vienna (MUW) are the first to use the high-resolution three-dimensional imaging method to visualize the network of blood vessels beneath the outer layer of the skin — the epidermis — that feed cancerous lesions. A laser light source developed at Ludwig Maximilian University was used to maximize image quality. It also enabled unprecedented high-speed imaging and operated at a near-infrared wavelength for better skin penetration. “The condition of the ...

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    2. Optical Coherence Tomography Dermatology Image Atlas

      Optical Coherence Tomography Dermatology Image Atlas

      A OCT poster from recent European Academy of Dermatology and Venereology Meeting. See PDF HERE. Optical Coherence Tomography is a low-intensity laser based imaging technique that can image up to 2mm beneath the skin. The OCT probe moves across a lesion creating a continuous black and white movie of multiple vertical sections, similar to a the vertical orientation of histology and provides more cellular resolution than seen with ultrasound technology.

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    3. Optical Coherence Tomography Imaging of Onychomycosis

      Optical Coherence Tomography Imaging of Onychomycosis

      A OCT poster from recent European Academy of Dermatology and Venereology Meeting. Optical coherence tomography (OCT) is a non-invasive imaging technique that uses a low-power infrared laser light to image up to 2mm beneath the skin’s surface. This allows the clinician to obtain real-time images of the architecture of the skin, without any pre-treatment or gels. OCT has shown to be a useful diagnostic tool for conditions of the nail, such as psoriatic nail disorder1. Described is a case of a 56 year old male patient who presented on initial exam with yellow discoloration on all toenails and subungal ...

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    4. In situ structural and microangiographic assessment of human skin lesions with high-speed OCT

      In situ structural and microangiographic assessment of human skin lesions with high-speed OCT

      We demonstrate noninvasive structural and microvascular contrast imaging of different human skin diseases in vivo using an intensity difference analysis of OCT tomograms. The high-speed swept source OCT system operates at 1310 nm with 220 kHz A-scan rate. It provides an extended focus by employing a Bessel beam. The studied lesions were two cases of dermatitis and two cases of basal cell carcinoma. The lesions show characteristic vascular patterns that are significantly different from healthy skin. In case of inflammation, vessels are dilated and perfusion is increased. In case of basal cell carcinoma, the angiogram shows a denser network of ...

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    5. Agfa HealthCare launches SKINTELL non-invasive high-definition Optical Coherence Tomography solution

      Agfa HealthCare launches SKINTELL non-invasive high-definition Optical Coherence Tomography solution

      Agfa Healthecare Press Release - High resolution technology provides 3D imaging of the epidermal and dermal skin layers in three different viewing modes Technology offers very fast, comfortable solution for visualizing skin morphology and measuring dimensions in the skin layers Three viewing modes: slice (like a B-scan), 3D and en face; providing different perspectives Very fast results: even a 3D image is taken in 1 second Agfa HealthCare announces today that it will launch its SKINTELL high-definition optical coherence tomography (HD-OCT) solution at the 21st congress of the European Academy of Dermatology and Venereology (EADV) in Prague. This non-invasive imaging technology ...

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    6. Tissues Tell the Tale: Non-Invasive Optical Technique Detects Cancer By Looking Under the Skin

      Tissues Tell the Tale: Non-Invasive Optical Technique Detects Cancer By Looking Under the Skin

      European researchers image blood vessels that feed skin cancer with OCT for the first time The trained eye of a dermatologist can identify many types of skin lesions, but human sight only goes so far. Now an international team of researchers has developed an advanced optics system to noninvasively map out the network of tiny blood vessels beneath the outer layer of patients’ skin, potentially revealing telltale signs of disease. Such high resolution 3-D images could one day help doctors better diagnose, monitor, and treat skin cancer and other skin conditions. The research was published today in the Optical Society ...

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    7. A randomized, half-side comparative study of aminolaevulinate photodynamic therapy vs. CO2 laser ablation in immunocompetent patients with multiple actinic keratoses

      A randomized, half-side comparative study of aminolaevulinate photodynamic therapy vs. CO2 laser ablation in immunocompetent patients with multiple actinic keratoses

      Background  Photodynamic therapy (PDT) and laser ablation (LA) are frequently used treatment options for multiple actinic keratoses (AK), yet they have not been compared head to head. Objectives  To compare PDT and carbon dioxide (CO2) LA in the management of multiple AK using objective and subjective outcome measures. Methods  A single-centre, randomized, two-treatment half-side comparative study of PDT vs. CO2 LA was performed. Patients with at least four bilateral (e.g., scalp, forearms) AK were included. The primary outcome measure was the reduction of AK 3 months (v3) after therapy. Secondary outcome measures included the reduction of AK 4 weeks ...

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    8. International Society for Biophysics and Imaging of Skin conference to take place in Copenhagen, 28-30 Nov, 2012

      International Society for Biophysics and Imaging of Skin conference to take place in Copenhagen, 28-30 Nov, 2012

      Below please find a weblink for the programme for the International Society for Biophysics and Imaging of Skin conference that will take place in Copenhagen, 28-30 Nov, 2012. There is a session dedicated to the use of OCT in clinical dermatology and cosmetic research The session will be co chaired by Prof Julia Welzel and Dr Mette Mogensen.  To find our more information please click HERE.

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    9. Feasibility of using Optical Coherence Tomography to Study the Influence of Skin Structure on Finger Friction

      Feasibility of using Optical Coherence Tomography to Study the Influence of Skin Structure on Finger Friction

      This paper presents work using an in-vivo technique, Optical Coherence Tomography (OCT), to investigate the structure of human finger pad skin and the influences of some related parameters on skin friction, such as contact area, deformation and hydration. The experimental results show that there was no significant relationship between the thickness of the stratum corneum (SC) and the friction coefficient, as well as the number of sweat ducts (SD). The real contact length was found to increase with increasing the applied normal force following the power law of A∝aW. The study of hydration found an increasing linear relationship between ...

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    10. In-vivo Optical Coherence Tomography Imaging in Dermatooncology

      In-vivo Optical Coherence Tomography Imaging in Dermatooncology

      In vivo differentiation of benign and malignant skin lesions is a fundamental issue in clinical dermatology. Malignant skin diseases are known to be accompanied by structural alterations. Conventional excisional biopsies and further histopathology are regarded as the reference standard for investigating these pathologies. Biopsies are invasive procedures and additionally may cause side effects. Therefore, research efforts are focused on the development of diagnostic techniques capable of providing in vivo information on the skin's structure. Optical coherence tomography (OCT) is a technical application, which allows the identification of microscopic patterns indicative for benign and malignant skin lesions. OCT is a ...

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    11. High-definition optical coherence tomography enables visualization of individual cells in healthy skin: comparison to reflectance confocal microscopy

      High-definition optical coherence tomography enables visualization of individual cells in healthy skin: comparison to reflectance confocal microscopy

      High-definition OCT (HD-OCT) is an innovative technique based on the principle of conventional OCT. Our objective was to test the resolution and image quality of HD-OCT in comparison with reflectance confocal microscopy (RCM) of healthy skin. Firstly, images have been made of a ultra-high-resolution line-pair phantome with both systems. Secondly, we investigated 21 healthy volunteers of different phototypes with HD-OCT and RCM on volar forearm and compared the generated images. HD-OCT displays also differences depending on the skin phototype and anatomical site. The 3-μm lateral resolution of the HD-OCT could be confirmed by the phantom analysis. The identification of ...

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    12. Washington University Receives a 2012 NIH Grant for Smart Laser Treatment of Port-Wine Stain in Children

      Washington University Receives a 2012 NIH Grant for Smart Laser Treatment of Port-Wine Stain in Children

      Washington University Receives a 2012 NIH Grant for $84,965 for Smart Laser Treatment of Port-Wine Stain in Children. The program is a multi-year program and started in 2012 and ends in 2014. The principle investigator is Bin Rao. A brief description of the project is given below. Due to the lack of port-wine stain (PWS) lesion information, there is a fundamental gap in achieving the optimum therapeutic outcome of laser treatment of PWS in children. The existence of this gap for the past 30 years represents a long-standing clinical problem, and urgently demands a smart PWS laser treatment system ...

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    13. Superficial wounding model for epidermal barrier repair studies: Comparison of Erbium:YAG laser and the suction blister method

      Superficial wounding model for epidermal barrier repair studies: Comparison of Erbium:YAG laser and the suction blister method

      Background and Objectives Wound-healing studies use mainly mechanical methods for wound induction, which are laborious and difficult to standardize. Objective of this study was to evaluate the Erbium:Yttrium-Aluminium-Garnet (Er:YAG) laser method as a model of epidermis ablation on human skin in vivo and to compare the quality and healing rates of Er:YAG laser and suction blister (SB) wounds. Materials and Methods Er:YAG laser and SB wounds were made on the forearms of 10 healthy volunteers. Post-wounding measurements including wound surface area (WSA) from photographs, wound depth from 3D volume analysis, trans-epidermal water loss (TEWL), laser doppler ...

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    14. Imaging of basal cell carcinoma by high-definition optical coherence tomography. Histomorphologic correlation a pilot study

      Imaging of basal cell carcinoma by high-definition optical coherence tomography. Histomorphologic correlation a pilot study

      Background:  With the continued development of non-invasive therapies for BCC such as PDT and immune therapies, the non-invasive diagnosis and monitoring become increasingly relevant. High-definition optical coherence tomography is a high-resolution imaging tool, with micrometer resolution in both transversal and axial directions, enable to visualize individual cells up to a depth of around 570 μm filling the imaging gap between conventional optical coherence tomography and reflectance confocal microscopy. Objective:  We sought to determine the feasibility of detecting basal cell carcinoma by this technique using criteria defined for reflectance confocal microscopy and conventional optical coherence tomography and compared to histology. Method ...

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    15. Actinic keratosis in the en-face and slice imaging mode of high definition optical coherence tomography and comparison with histology

      Actinic keratosis in the en-face and slice imaging mode of high definition optical coherence tomography and comparison with histology

      Optical coherence tomography (OCT) allows real-time, in vivo examination of non-melanoma skin cancer. An innovative high-definition (HD)-OCT with a horizontal (en-face) and vertical (slice) imaging mode offers additional information in the diagnosis of actinic keratosis (AK) and may potentially replace invasive diagnostic biopsies. Objectives:  To define the characteristic morphologic features of AK by using HD-OCT in the two imaging modes compared to histopathology as gold standard. Methods:  A total of 20 AKs were examined by HD-OCT in the en-face and slice imaging mode and characteristic features were described and evaluated in comparison to the histopathological findings. Furthermore, the HD-OCT ...

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    16. Hair shaft abnormalities after chemotherapy and tamoxifen therapy in breast cancer patients evaluated by optical coherence tomography

      Hair shaft abnormalities after chemotherapy and tamoxifen therapy in breast cancer patients evaluated by optical coherence tomography

      Background:  Antineoplastic treatment for breast cancer is frequently associated with alopecia. Increasingly, changes in texture and shape of regrowing hair after chemotherapy have been reported, without evaluation on a scientific basis. Optical coherence tomography (OCT) provides highly reproducible measurements of hair shaft parameters. Objectives:  This study aims at evaluating hair shaft alterations using OCT in chemotherapy-induced alopecia and in patients taking tamoxifen. Methods:  The measurements of this prospective case series were performed on women, aged 29–68 years, receiving either tamoxifen (n = 17) or chemotherapy (n = 17) prior to (T1) and after (T2) treatment. Each time, 20 hairs from 2 ...

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    17. Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: A review

      Noninvasive clinical assessment of port-wine stain birthmarks using current and future optical imaging technology: A review

      Port wine stain (PWS) birthmarks are one class of benign congenital vascular malformation. Laser therapy is the most successful treatment modality of PWS. Unfortunately, this approach has limited efficacy, with only 10% of patients experiencing complete blanching of the PWS. To address this problem, several research groups have developed technologies and methods designed to study treatment outcome and improve treatment efficacy. This paper reviews seven optical imaging techniques currently in use or under development to assess treatment efficacy, focusing on: Reflectance spectrophotometers/tristimulus colorimeters, Laser Doppler flowmetry (LDF) and Laser Doppler imaging (LDI), Cross-polarized diffuse reflectance color imaging system (CDR ...

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    18. Assessment of transcutaneous vaccine delivery by optical coherence tomography

      Assessment of transcutaneous vaccine delivery by optical coherence tomography

      Immunization is one of the most efficient and cost-effective means for the prevention of diseases. The latest trend for inducing protective immunity is topical application of vaccines to intact skin rather than invasive administration via injection. Apart from being a non-invasive route of drug delivery, skin itself also offers advantages through the presence of cells of the immune system in both the dermis and epidermis. However, vaccine penetration through the outermost layers of skin is limited by the barrier provided by the Stratum corneum. In the current study utilizing conventional Optical Coherence Tomography (OCT) we investigate the transcutaneous delivery of ...

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    19. LLTech Releases Skin-Atlas of Images using Full-Field OCT Light-CT Scanner

      LLTech Releases Skin-Atlas of Images using Full-Field OCT Light-CT Scanner

      LLTech Press Release - LLTech Recently release an Atlas of Skin Images using the LLTech Field OCT Light-CT Scanner. A copy of the presentation can be seen HERE. About LLTech LLTech is a privately owned company founded in 2007. LLTech vision is to become the leader in real time, safe, non-destructive optical biopsies and cellular level tissue imaging for research and clinical applications (needle core biopsies assessment, surgical margins…). Using the properties of white light and optics the Light-CT research scanner generates DICOM 3D high-resolution three-dimensional images of tissue microstructure, without introducing artifacts.

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    20. Research Shows OCT Images Useful for Assessing Skin Cancer Thickness

      Research Shows OCT Images Useful for Assessing Skin Cancer Thickness

      Michelson Diagnostics Press Release - Research conducted at Guy’s and St Thomas’ NHS Foundation Trust in London has shown that a new skin imaging technology (Optical Coherence Tomography, or ‘OCT’), could be used for assessing the depth, and therefore the degree of malignancy, of the most common type of skin cancer. The work could enable greater and more effective use of non-invasive treatments for skin cancer, as an alternative to surgery, which can leave unsightly scars. The publicly funded research, published in the peer-reviewed journal Skin Research And Technology 1 (Wiley), was performed in a collaboration between the Medical Physics ...

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    21. University of Illinois at Urbana-Champaign Wins NIH Grant for Developing Technology for Primary Care Imaging

      University of Illinois at Urbana-Champaign Wins NIH Grant for Developing Technology for Primary Care Imaging

      University of Illinois at Urbana-Champaign received a 2012 NIH Grant for $943,269 for Developing Partnership for Primary Care Imaging. The program is part of a multiyear study that started in 2011 and ends in 2016. The principal investigator is Stephen Boppart. Below is a summary of the proposed work.  Primary Care Medicine, including Family Practice and Pediatrics, has traditionally relied on physical exam skills and simplistic instruments for critical diagnostic decision making, monitoring, and referral to medical specialists. The otoscope and ophthalmoscope are two historical and ubiquitous instruments that largely only illuminate and magnify tissue surfaces in the ear ...

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    22. System and method for creating a stable optical interface

      System and method for creating a stable optical interface

      A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal ...

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    23. OCT skin image enhancement through attenuation compensation

      OCT skin image enhancement through attenuation compensation

      The enhancement of optical coherence tomography (OCT) skin images can help dermatologists investigate the morphologic information of the images more effectively. In this paper, we propose an enhancement algorithm with the stages that includes speckle reduction, skin layer detection, and attenuation compensation. A weighted median filter is designed to reduce the level of speckle while preserving the contrast. A novel skin layer detection technique is then applied to outline the main skin layers: stratum corneum, epidermis, and dermis. The skin layer detection algorithm does not make any assumption about the structure of the skin. A model of the light attenuation ...

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    24. Imaging Cutaneous T-Cell Lymphoma with Optical Coherence Tomography

      Imaging Cutaneous T-Cell Lymphoma with Optical Coherence Tomography

      Aim: To investigate the presentation of a patch-stage cutaneous T-cell lymphoma (CTCL) using optical coherence tomography (OCT). Methods: A patient with a patch caused by CTCL was photographed digitally, OCT-scanned and biopsied. A normal skin area adjacent to the patch was OCT-scanned for comparison, but not biopsied. The OCT image and the histological image were compared. Results: The OCT images illustrated a thickened and hyperreflective stratum corneum. OCT also demonstrated several elongated hyporeflective structures in the dermis. The largest structure was measured to have a width of 0.13 mm. A good immediate correlation was found between histology and OCT ...

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