1. Articles in category: Dermatology

    265-288 of 550 « 1 2 ... 9 10 11 12 13 14 15 ... 21 22 23 »
    1. Complex assessment of age-specific morphofunctional features of skin of different anatomic localizations

      Complex assessment of age-specific morphofunctional features of skin of different anatomic localizations

      Objective The goal of the described study was complex assessment of age-specific morphofunctional features of skin of different anatomic localization using optical coherence tomography (OCT). Methods Forty-three healthy volunteers aging from 4 to 74 years were enrolled in the study. Optical and functional skin parameters were studied in 18 areas of the human body. All the studied areas were classified as open and closed, depending on external impact. Structural parameters of skin were determined by means of the OCT device equipped with a removable, flexible probe with microscanner (registration certificate no. 022a2035/2213-05) designed and fabricated at the IAP RAS ...

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    2. Three-dimensional multiphoton/optical coherence tomography for diagnostic applications in dermatology

      Three-dimensional multiphoton/optical coherence tomography for diagnostic applications in dermatology

      A preliminary clinical trial using state-of-the-art multiphoton tomography (MPT) and optical coherence tomography (OCT) for three-dimensional (3D) multimodal in vivo imaging of normal skin, nevi, scars and pathologic skin lesions has been conducted. MPT enabled visualization of sub-cellular details with axial and transverse resolutions of <2 μm and <0.5 μm, respectively, from a volume of 0.35 × 0.35 × 0.2 mm3 at a frame rate of 0.14 Hz (512 × 512 pixels). State-of-the-art OCT, operating at a center wavelength of 1300 nm, was capable of acquiring 3D images depicting the layered architecture of skin with axial and transverse ...

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    3. Polarization sensitive optical coherence tomography of melanin provides intrinsic contrast based on depolarization

      Polarization sensitive optical coherence tomography of melanin provides intrinsic contrast based on depolarization

      Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of OCT. In addition to imaging based on tissue reflectivity, PS-OCT also enables depth-resolved mapping of sample polarization properties such as phase-retardation, birefringent axis orientation, Stokes vectors, and degree of polarization uniformity (DOPU). In this study, PS-OCT was used to investigate the polarization properties of melanin. In-vitro measurements in samples with varying melanin concentrations revealed polarization scrambling, i.e. depolarization of backscattered light. Polarization scrambling in the PS-OCT images was more pronounced for higher melanin concentrations and correlated with the concentration of the melanin granules in the phantoms. Moreover, in-vivo ...

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    4. Influence of finishing textile materials on the reduction of skin irritations

      Influence of finishing textile materials on the reduction of skin irritations

      Background An increasing number of people is reported to have sensitive skin. Consequently, the development of textile materials with comfortable wearing properties has become a major interest. One method to create a pleasant sensation of textile materials on the skin is to coat them with silk proteins. This technologically complex procedure requires both optimization and control. Methods The present study was aimed to characterize the subjective perception of different textiles and to objectively assess their influence on skin morphology with non-invasive optical techniques like optical coherence tomography (OCT), laser scanning microscopy (LSM) and optical surface profilometry (OP). Furthermore, optical methods ...

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    5. Influence of skin model on in vitro performance of drug-loaded soluble microneedle arrays

      Influence of skin model on in vitro performance of drug-loaded soluble microneedle arrays

      A plethora of studies have described the in vitro assessment of dissolving microneedle (MN) arrays for enhanced transdermal drug delivery, utilising a wide variety of model membranes as a representation of the skin barrier. However, to date, no discussion has taken place with regard to the choice of model skin membrane and the impact this may have on the evaluation of MN performance. In this study, we have, for the first time, critically assessed the most common types of in vitro skin permeation models – a synthetic hydrophobic membrane (Silescol® of 75 μm) and neonatal porcine skin of definable thickness (300 ...

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    6. Window on the skin reveals cancers

      Window on the skin reveals cancers

      Michelson Diagnostics Press Release - A revolutionary new scanner has been developed that will improve dramatically the accuracy of treatment for skin cancer, cutting NHS costs and reducing recurrence rates. The need: Non-melanoma skin cancer is becoming increasingly common. More than 100,000 cases are now diagnosed in the UK each year, according to Cancer Research UK. There are several different types of non- melanoma skin cancer and these are different from the types that develop from abnormal moles (melanoma). The standard cure is surgical removal, but until now, surgeons have had to guess how much skin tissue to remove around ...

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    7. Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

      Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

      The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three fold increase in the OCT reflectance from a 300 μm depth and 31% enhancement in image depth Zthreshold.

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    8. Practical approach for dispersion compensation in spectral-domain optical coherence tomography

      Practical approach for dispersion compensation in spectral-domain optical coherence tomography

      e proposed and demonstrated a digital method of dispersion compensation suitable for spectral-domain optical coherence tomography. The wavelength coordinate of the coherence spectrum was calibrated digitally using a two-order polynomial. A software-based scheme was introduced to determine the polynomial coefficients of the polynomial fitting spectrum wavelength. Therefore, the spectrum deformation introduced by dispersion can be compensated effectively. This method was experimentally validated by in vivo imaging an early-stage chick embryonic heart.

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      Mentions: Yi Wang
    9. Prehistological evaluation of benign and malignant pigmented skin lesions with optical computed tomography

      Prehistological evaluation of benign and malignant pigmented skin lesions with optical computed tomography

      Discrimination of benign and malignant melanocytic lesions is a major issue in clinical dermatology. Assessment of the thickness of melanoma is critical for prognosis and treatment selection. We aimed to evaluate a novel optical computed tomography (optical-CT) system as a tool for three-dimensional (3-D) imaging of melanocytic lesions and its ability to discriminate benign from malignant melanocytic lesions while simultaneously determining the thickness of invasive melanoma. Seventeen melanocytic lesions, one hemangioma, and normal skin were assessed immediately after their excision by optical-CT and subsequently underwent histopathological examination. Tomographic reconstructions were performed with a back-propagation algorithm calculating a 3-D map of ...

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    10. In vivo imaging of human burn injuries with polarization-sensitive optical coherence tomography

      In vivo imaging of human burn injuries with polarization-sensitive optical coherence tomography

      The accurate determination of burn depth is critical in the clinical management of burn wounds. Polarization-sensitive optical coherence tomography (PS-OCT) has been proposed as a potentially non-invasive method for determining burn depth by measuring thermally induced changes in the structure and birefringence of skin, and has been investigated in pre-clinical burn studies with animal models and ex vivo human skin. In this study, we applied PS-OCT to the in-vivo imaging of two pediatric burn patients. Deep and superficial burned skins along with contralateral controls were imaged in 3D. The imaging size was 8  mm×6  mm×2  mm in width ...

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    11. Effects of optical clearing agents on noninvasive blood glucose monitoring with optical coherence tomography: a pilot study

      Effects of optical clearing agents on noninvasive blood glucose monitoring with optical coherence tomography: a pilot study

      Recently, the capability of optical coherence tomography (OCT) has been demonstrated for noninvasive blood glucose monitoring. In this work, we investigate the administration of chemical agents onto human skin tissue to increase the transparency of the surface of the skin, as a means of improving the capability of OCT imaging for clinically relevant applications. Eight groups of experiments were proposed, in which different optical clearing agents (OCA) were used. The results indicate that, when properly used, some OCAs perform well in promoting the capability of OCT for noninvasive blood glucose monitoring. Among the four kinds of OCA we used, 50 ...

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    12. New Frontiers in Laser Surgery

      New Frontiers in Laser Surgery

      The simultaneous advances in engineering, medicine, and molecular biology have accelerated the pace of introductions of new light-based technologies in dermatology. In this review, the authors examine recent advances in laser surgery as well as peer into the future of energy-based cutaneous medicine. The future landscape of dermatology will almost undoubtedly include (1) noninvasive imaging technologies and (2) improved “destructive” modalities based on real-time feedback from the skin surface.

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      Mentions: UCSD
    13. New Technique For Assessment of Scleroderma Using Vivosight OCT Wins The Abbot Innovation Award At British Society For Rheumatology

      New Technique For Assessment of Scleroderma Using Vivosight OCT Wins The Abbot Innovation Award At British Society For Rheumatology

      A presentation entitled “ Optical coherence tomography validation: a new quantitative imaging biomarker for affected skin in scleroderma ” by Dr Giuseppina Abignano at the Leeds Musculoskeletal Biomedical Research Unit has been awarded the Abbott Innovations Award at the British Society for Rheumatology’s annual conference earlier this month (image below). The research, undertaken at the Leeds Musculoskeletal Biomedical Research Unit, investigates the use of the VivoSight Topical OCT Probe, an innovative skin imaging technology, to assess tell-tale patterns in collagen deposits and vascularisation within the top layers of the skin of scleroderma sufferers. Scleroderma is a chronic multisystem autoimmune disease which ...

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    14. Real-time display with large field of view on fourier domain optical coherence tomography at 1310 nm wavelength for dermatology

      Real-time display with large field of view on fourier domain optical coherence tomography at 1310 nm wavelength for dermatology

      Abstract  A Fourier domain optical coherence tomography (OCT) system with 1310 nm light was demonstrated to study inflammatory human skin and the skin coated with a moisturizer in vivo. By using a graphics processing unit (GPU), the display rate could reach 20 frames/s with 1000 A-scans contained in one image. The field of view (FOV) of the cross-sectional image is 7 mm in the lateral direction and the penetration depth is ∼1 mm in skin. The result shows that, in inflammatory skin, the epidermis became thicker and had a decreased scattering; furthermore, the region of the severe lesion present ...

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    15. Evaluating In Vivo OCT Imaging for Periocular Basal Cell Carcinoma

      Evaluating In Vivo OCT Imaging for Periocular Basal Cell Carcinoma

      Optical coherence tomography (OCT) is an imaging technique which shows the internal structure of living tissue (in vivo). It is safe, quick and painless to perform, and does not damage the tissue in any way. Recent advances in the technology mean that it can now be used to take images of the internal structure of the skin. This is useful because certain conditions, such as skin cancers, alter this structure. At present a suspected skin cancer is identified by taking a sample (a biopsy) which is analysed under the microscope to confirm the diagnosis. The cancer is then excised including ...

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    16. Analysis of the efficiency of hair removal by different optical methods: comparison of Trichoscan, reflectance confocal microscopy, and optical coherence tomography

      Analysis of the efficiency of hair removal by different optical methods: comparison of Trichoscan, reflectance confocal microscopy, and optical coherence tomography

      Noninvasive diagnostic tools, such as Trichoscan®, reflectance confocal microscopy (RCM), and optical coherence tomography (OCT), are efficient methods of hair shaft and growth evaluation. The aim of this study was to carry out a comparative assessment of these three medical procedures by measuring the hair shaft and hair growth after hair removal for a defined period of five days. The application of these techniques was demonstrated by measuring hair growth on the lower leg of six female volunteers. After removal of the hair shaft with a shaving system, the hair follicle infundibula and the length of the growing hairs were ...

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    17. Morphology of basal cell carcinoma in high definition optical coherence tomography: en-face and slice imaging mode, and comparison with histology

      Morphology of basal cell carcinoma in high definition optical coherence tomography: en-face and slice imaging mode, and comparison with histology

      Background  Optical coherence tomography (OCT) allows real-time, in vivo examination of basal cell carcinoma (BCC). A new high definition OCT with high lateral and axial resolution in a horizontal (en-face) and vertical (slice) imaging mode offers additional information in the diagnosis of BCC and may potentially replace invasive diagnostic biopsies. Objectives  To define the characteristic morphologic features of BCC by using high definition optical coherence tomography (HD-OCT) compared to conventional histology. Methods  A total of 22 BCCs were examined preoperatively by HD-OCT in the en-face and slice imaging mode and characteristic features were evaluated in comparison to the histopathological findings ...

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    18. Confocal laser scanning microscopy as a new valuable tool in the diagnosis of onychomycosis – comparison of six diagnostic methods

      Confocal laser scanning microscopy as a new valuable tool in the diagnosis of onychomycosis – comparison of six diagnostic methods

      Onychomycosis is common and can mimic several different nail disorders. Accurate diagnosis is essential to choose the optimum antifungal therapy. The aim of this study was to evaluate the use of confocal laser scanning microscopy (CLSM) and optical coherence tomography (OCT) as new non-invasive diagnostic tools in onychomycosis and to compare them with the established techniques. In a prospective trial, 50 patients with suspected onychomycosis and 10 controls were examined by CLSM and OCT. Parallel KOH preparation, culture, PAS-staining and PCR were performed. PCR showed the highest sensitivity, followed by CLSM, PAS and KOH preparation. OCT offered the second best ...

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    19. Ablation efficiency and relative thermal confinement measurements using wavelengths 1,064, 1,320, and 1,444 nm for laser-assisted lipolysis

      Ablation efficiency and relative thermal confinement measurements using wavelengths 1,064, 1,320, and 1,444 nm for laser-assisted lipolysis

      Abstract  Laser-assisted lipolysis is routinely used for contouring the body and the neck while modifications of the technique have recently been advocated for facial contouring. In this study, wavelength-dependence measurements of laser lipolysis effect were performed using different lasers at 1,064, 1,320, and 1,444 nm wavelengths that are currently used clinically. Fresh porcine skin with fatty tissue was used for the experiments with radiant exposure of 5–8 W with the same parameters (beam diameter = 600 μm, peak power = 200 mJ, and pulse rate = 40 Hz) for 1,064, 1,320 and 1,444 nm laser wavelengths ...

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    20. Noninvasive test methods for epidermal barrier function

      Noninvasive test methods for epidermal barrier function

      New bioengineering techniques provide noninvasive opportunities to evaluate clinically the application of various products on the skin. The skin barrier function and its integrity can be studied by transepidermal water loss, stratum corneum water content, transcutaneous flux of carbon dioxide and oxygen, and transepidermal movement of ions, particularly chloride, potassium, and hydrogen ions. The benefits of noninvasive techniques are due not only to their lack of skin barrier destruction but also to their potential for early detection of any subclinical effects not detected by the naked eyes

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    21. Full-Field Optical Coherence Tomography: A New Technology for 3D High-Resolution Skin Imaging

      Full-Field Optical Coherence Tomography: A New Technology for 3D High-Resolution Skin Imaging

      Background/Aims: Full-field optical coherence tomography (FFOCT) is a new imaging technology that can provide 3D micron-level resolution and is suited for high-resolution imaging of biological tissue. The aim of this study was to evaluate its capacity and potential for imaging human epidermis and dermis and various skin pathologies in ex vivo and in vivo conditions. Methods: Non-fixed and fixed samples of normal and pathological skin and normal in vivo skin were imaged with a FFOCT system and compared to histological slides. Results: The epidermis and adnexae, the collagen bundles of the dermis and the hypodermis could be identified through ...

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    22. Full-field optical coherence tomography: a new technology for 3D high resolution skin imaging

      Full-field optical coherence tomography: a new technology for 3D high resolution skin imaging

      Background/Aims : Full-field optical coherence tomography (FFOCT) is a new imaging technology that can provide 3D micron-level resolution and is suited for high resolution imaging of biological tissue. The aim of this study is to evaluate its capacity and potential for imaging human epidermis and dermis and various skin pathologies in ex- and in-vivo conditions. Methods : Non fixed and fixed samples of normal and pathological skin and normal in-vivo skin were imaged with a FFOCT system and compared to histological slides. Results: The epidermis and adnexae, the collagen bundles of the dermis and the hypodermis could be identified through architectural ...

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    23. Visualization of hair follicles using high-speed optical coherence tomography based on a Fourier domain mode locking laser

      Visualization of hair follicles using high-speed optical coherence tomography based on a Fourier domain mode locking laser

      Abstract  In this study, a swept-source optical coherence tomography (SS-OCT) system with a Fourier domain mode locking (FDML) laser is proposed for a dermatology study. The homemade FDML laser is one kind of frequency-sweeping light source, which can provide output power of >20 mW and an output spectrum of 65 nm in bandwidth centered at 1300 nm, enabling imaging with an axial resolution of 12 μm in the OCT system. To eliminate the forward scans from the laser output and insert the delayed backward scans, a Mach-Zehnder configuration is implemented. Compared with conventional frequency-sweeping light sources, the FDML laser can ...

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    24. Qualitative investigation of fresh human scalp hair with full-field optical coherence tomography

      Qualitative investigation of fresh human scalp hair with full-field optical coherence tomography

      We have investigated depth-resolved cellular structures of unmodified fresh human scalp hairs with ultrahigh-resolution full-field optical coherence tomography (FF-OCT). The Linnik-type white light interference microscope has been home-implemented to observe the micro-internal layers of human hairs in their natural environment. In hair shafts, FF-OCT has qualitatively revealed the cellular hair compartments of cuticle and cortex layers involved in keratin filaments and melanin granules. No significant difference between black and white hair shafts was observed except for absence of only the melanin granules in the white hair, reflecting that the density of the melanin granules directly affects the hair color. Anatomical ...

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