1. Articles in category: Dermatology

    265-288 of 455 « 1 2 ... 9 10 11 12 13 14 15 ... 17 18 19 »
    1. Automatic measurement of epidermal thickness from optical coherence tomography images using a new algorithm

      Automatic measurement of epidermal thickness from optical coherence tomography images using a new algorithm
      Background/purpose: Optical coherence tomography (OCT) is an imaging system that enables in vivo epidermal thickness (ET) measurement. In order to use OCT in large-scale clinical studies, automatic algorithm detection of the dermo-epidermal junction (DEJ) is needed. This may be difficult due to image noise from optical speckle, which requires specific image treatment procedures to reduce this. In the present work, a description of the position of the DEJ is given, and an algorithm for boundary detection is presented. Methods: Twenty-nine images were taken from the skin of normal healthy subjects, from five different body sites. Seven expert assessors were ...
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    2. A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers

      A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers

      Background and Objective The current standard for diagnosis of skin cancers is visual inspection followed by biopsy and histopathology. This process can be invasive, subjective, time consuming, and costly. Optical techniques, including Optical Coherence Tomography (OCT) and Raman Spectroscopy (RS), have been developed to perform non-invasive characterization of skin lesions based on either morphological or biochemical features of disease. The objective of this work is to report a clinical instrument capable of both morphological and biochemical characterization of skin cancers with RS-OCT. Materials and Methods The portable instrument utilizes independent 785 nm RS and 1,310 nm OCT system backbones ...

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    3. Dr Stephen Matcher Biomedical Imaging Expert Seconded to Michelson Diagnostics

      Dr Stephen Matcher Biomedical Imaging Expert Seconded to Michelson Diagnostics
      Michelson Diagnostics Press Release -  Dr Stephen Matcher, Senior Lecturer in Biomedical Engineering at the Department of Materials Science and Engineering at the University of Sheffield, has been seconded to Orpington, UK-based start-up Michelson Diagnostics Ltd for 6 months, to provide the company with the benefits of his expertise in Optical Coherence Tomography (OCT), an advanced technique for skin imaging used in their products.   The secondment is enabled by a grant from the Royal Academy of Engineering (RAE) Industrial Secondment Scheme. This scheme is intended to help companies gain access to highly qualified academic expertise and to build links with universities ...
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    4. Octopus increases stake in cancer imaging firm, Michelson Diagnostics Ltd., with £300k investment

      Octopus increases stake in cancer imaging firm, Michelson Diagnostics Ltd., with £300k investment
      Michelson Diagnostics Press Release - A second investment of £300k into Michelson Diagnostics (‘Michelson’) has been made by Octopus Investments (‘Octopus’). This adds to the initial investment of £1.7M in October 2010 by Octopus into Michelson, the medical equipment and scanner specialists, whose unique laser scanning technology can image skin and other surface tissue at a much higher resolution than ever before. Michelson anticipates that the VivoSight scanner could revolutionise the treatment of non-melanoma skin cancer, by providing dermatologists with a new way of seeing abnormalities that are hidden below the skin surface.    The VivoSight scanner has already won CE ...
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    5. Monitoring skin photodamage using quantitative optical coherence tomography

      Monitoring skin photodamage using quantitative optical coherence tomography
      Noninvasive, real-time imaging technology assists UV light therapy of skin diseases and facilitates reduction of the associated photodamage. In clinical medicine, 8-methoxypsoralen (8-MOP) combined with ultraviolet A (UVA; 320–400nm) (PUVA) therapy is an effective and widely used treatment for several types of dermatose, including psoriasis, mycosis fungoides, and vitiligo. However, many studies have shown that PUVA has both potent mutagenic and carcinogenic effects and also immunosuppressive consequences. The latter can allow tumor development or changes to the immune function in both immuno-suppressed and healthy individuals.1,2 Long-term PUVA therapy significantly increases the risk of skin-cancer development.3,4
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    6. State of the art in non-invasive imaging of cutaneous melanoma

      State of the art in non-invasive imaging of cutaneous melanoma
      Background: This review focuses on looking at recent developments in the non-invasive imaging of skin, in particular at how such imaging may be used at present or in the future to detect cutaneous melanoma. Methods: A MEDLINE search was performed for papers using imaging techniques to evaluate cutaneous melanoma, including melanoma metastasis. Results: Nine different techniques were found: dermoscopy, confocal laser scanning microscopy (including multiphoton microscopy), optical coherence tomography, high frequency ultrasound, positron emission tomography, magnetic resonance imaging, and Fourier, Raman, and photoacoustic spectroscopies. This review contrasts the effectiveness of these techniques when seeking to image melanomas in skin. Conclusions ...
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    7. A New High-Resolution Method for Imaging Below the Skin using a Liquid Lens

      A New High-Resolution Method for Imaging Below the Skin using a Liquid Lens
      University of Rochester optics professor Jannick Rolland has developed an optical technology that provides unprecedented images under the skin's surface. The aim of the technology is to detect and examine skin lesions to determine whether they are benign or cancerous without having to cut the suspected tumor out of the skin and analyze it in the lab. Instead, the tip of a roughly one-foot-long cylindrical probe is placed in contact with the tissue, and within seconds a clear, high-resolution, 3D image of what lies below the surface emerges. Rolland will be presenting her findings at the 2011 annual meeting ...
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    8. Optical coherence tomography-guided photodynamic therapy for skin cancer: Case study

      Optical coherence tomography-guided photodynamic therapy for skin cancer: Case study
      Photodynamic therapy (PDT) has been identified as a successful therapy for skin cancer. This case study investigates the role of optical coherence tomography (OCT) in lesion (squamous cell carcinoma) mapping, assisting the surgeon to correctly deliver PDT and monitor the outcome. Optical coherence tomographic images were acquired pre-treatment to assess tumour extent and margins to enable guidance of the PDT. Tomographic images taken post-PDT up to 6 months revealed complete response to the treatment and no recurrence. OCT-guided PDT is one of the promising approaches to efficiently discriminate between tumor involved and noninvolved margins. It reduces the untoward healthy tissue ...
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    9. In vivo response of GsdmA3Dfl/+ mice to topically applied anti-psoriatic agents: effects on epidermal thickness, as determined by optical coherence tomography and H&E staining.

      In vivo response of GsdmA3Dfl/+ mice to topically applied anti-psoriatic agents: effects on epidermal thickness, as determined by optical coherence tomography and H&E staining.

      This study evaluated in vivo the potential of optical coherence tomography (OCT) to determine changes in thickness of the epidermis in response to the topically applied anti-psoriatics betamethasone dipropionate (BD), salicylic acid (SA) and also fish oil (FO). GsdmA3Dfl/+ mice have an inflammatory hair loss phenotype that includes hyperproliferation and epidermal thickening, hence a potential psoriasis model. Changes in epidermal thickness were evaluated over a period of 10 days, with the mice treated with combined BD + SA, FO + SA and BD + FO + SA. The data were validated with conventional measurement using H&E staining coupled with microscopy. Initial baseline measurement ...

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    10. Michelson Diagnostics Recruits Sales & Marketing Manager

      Michelson Diagnostics Recruits Sales & Marketing Manager
      Michelson Diagnostics Press Release - Skin cancer imaging firm Michelson Diagnostics Ltd has recruited Patrick Finnemore as Sales & Marketing Manager, UK & Europe. Patrick brings 25 years sales and marketing experience in the medTech industry. During his career Patrick has launched and commercialised a wide range of innovative high technology products for both large organisations and start-ups. Patrick started his career in marketing at Smith and Nephew where he was responsible for managing a portfolio of woundcare products. He subsequently worked at Baxter International and ConvaTec in a range of business management and international marketing roles.    In recent years he has worked ...
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    11. In Vivo Comparison of the Optical Clearing Efficacy of Optical Clearing Agents in Human Skin by Quantifying Permeability Using Optical Coherence Tomography

      In Vivo Comparison of the Optical Clearing Efficacy of Optical Clearing Agents in Human Skin by Quantifying Permeability Using Optical Coherence Tomography

      The objective of the present work is to quantify and compare the optical clearing efficacy of glucose, propylene glycol, glycerol solutions through the human skin tissue in vivo by calculating permeability coefficient of three solutions. Currently, the permeability coefficient of agent in tissues was extracted from OCT amplitude data mainly through the OCT signal slope (OCTSS) and the OCT amplitude (OCTA) methods. In this study, we report the OCT attenuation coefficient (OCTAC) method which is relatively novel and rarely reported methodology to measure the permeability coefficient during the optical skin clearing procedure. The permeability coefficients for 40% propylene glycol, glucose ...

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    12. In-vivo assessment of cleavage line orientation in human skin using optical coherence tomography

      In-vivo assessment of cleavage line orientation in human skin using optical coherence tomography
      Collagen and elastin fibers are generally arranged in parallel bundles within the dermis. These bundles are oriented such that they can most efficiently resist the stress and strain that normally occurs on the skin during movement. The pattern of these fiber bundles establishes the lines of cleavage of the skin. Knowledge of the orientation of these is of key importance for surgical procedures. When incisions are cut parallel to the cleavage line orientation the incision will heal better and produce less scaring. In this work we report a novel application of Optical coherence tomography for the determination of cleavage line ...
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    13. Michelson Diagnostics Expands

      Michelson Diagnostics Expands
      Michelson Diagnostics Press Release - Skin cancer imaging firm Michelson Diagnostics Ltd has announced that it is expanding its UK headquarters by leasing a 900 ft2 office suite. “Our requirements for more space to accommodate our growing manufacturing operations, research & development, and sales administration have resulted in a doubling of our premises area roughly every 18 months since we founded Michelson Diagnostics in 2006”, said Operations Director and co-Founder Martin Johns. “This trend looks set to continue in 2011 and beyond, as we are making excellent progress towards our business goals. For example, we plan to lease premises in the USA ...
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    14. Clinical application of optical coherence tomography for the imaging of non-melanocytic cutaneous tumors: a pilot multi-modal study

      Clinical application of optical coherence tomography for the imaging of non-melanocytic cutaneous tumors: a pilot multi-modal study
      Context: Optical coherence tomography (OCT) is an emergent imaging technique, based on the interference of infrared radiation and living tissues, that allows the in vivo visualization of the skin structures, at high resolution and up to 1.6 mm depth. As such, there is mounting evidence that OCT may be an interesting technique for the diagnosis of skin diseases, including the non-invasive early detection of cutaneous tumors. Objective: We aimed to investigate the utility of OCT for the diagnosis of non-melanocytic, non-pigmented cutaneous tumors. Methods: Preliminary results are presented from an initiated study. Fifteen consecutive patients with clinical suspicion of ...
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    15. Hair shaft abnormalities in alopecia areata evaluated by optical coherence tomography

      Hair shaft abnormalities in alopecia areata evaluated by optical coherence tomography

      Background/purpose: Optical coherence tomography (OCT) is able to provide highly reproducible measurements of hair shaft thickness, including hair shaft diameter, cross-sectional surface area and hair shape, similar to histology but in vivo. Variations in the caliber of hair shafts have been described in patchy hair loss like alopecia areata (AA) using electron microscopy. The aim of this study was to evaluate whether OCT is useful for the evaluation of hair shaft abnormalities in AA. Methods: The measurements were performed on patients with AA (n=9), aged 2–66 years. Fifty hairs from the border of an alopecic area and ...

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      Mentions: Jürgen Lademann
    16. Development of a Photographic Scale for Consistency and Guidance in Dermatologic Assessment of Forearm Sun Damage

      Development of a Photographic Scale for Consistency and Guidance in Dermatologic Assessment of Forearm Sun Damage
      Objectives To develop a photographic sun damage assessment scale for forearm skin and test its feasibility and utility for consistent classification of sun damage. Design For a blinded comparison, 96 standardized 8 x 10 digital photographs of participants' forearms were taken. Photographs were graded by an expert dermatologist using an existing 9-category dermatologic assessment scoring scale until all categories contained photographs representative of each of 4 clinical signs. Triplicate photographs were provided in identical image sets to 5 community dermatologists for blinded rating using the dermatologic assessment scoring scale. Setting Academic skin cancer prevention clinic with high-level experience in assessment ...
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    17. Noninvasive assessment of burn wound severity using optical technology: A review of current and future modalities

      Noninvasive assessment of burn wound severity using optical technology: A review of current and future modalities
      Clinical examination alone is not always sufficient to determine which burn wounds will heal spontaneously and which will require surgical intervention for optimal outcome. We present a review of optical modalities currently in clinical use and under development to assist burn surgeons in assessing burn wound severity, including conventional histology/light microscopy, laser Doppler imaging, indocyanine green videoangiography, near-infrared spectroscopy and spectral imaging, in vivo capillary microscopy, orthogonal polarization spectral imaging, reflectance-mode confocal microscopy, laser speckle imaging, spatial frequency domain imaging, photoacoustic microscopy, and polarization-sensitive optical coherence tomography.
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    18. Cancer Imaging Firm Wins Place on Future Health Mission to US

      Cancer Imaging Firm Wins Place on Future Health Mission to US
      (Orpington, UK) December 20, 2010 - Michelson Diagnostics Ltd, the Orpington, UK based developer and manufacturer of laser scanners for use in non-melanoma skin cancer diagnosis & treatment, is the only medical imaging company selected from more than 70 applicants to take part in the Future Health Mission 2011 to the USA.   The Future Health Mission 2011 is to San Francisco, coinciding with the annual J.P. Morgan Healthcare Investing Conference in early January.    According to the mission organisers, “The Future Health Mission 2011 will give the entrepreneurs behind these 20 growing healthcare technology companies the opportunity to engage with key people ...
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    19. Diagnosis of the deep partial-thickness burn wound of Skh-1 mouse with Optical Coherence Tomography

      Diagnosis of the deep partial-thickness burn wound of Skh-1 mouse with Optical Coherence Tomography
      (Article in Chinese) Objective To evaluate the application value of Optical Coherence Tomography (OCT)in the diagnosis of the depth of burn wound. Methods Deep partial-thickness scald models of Skh-1 mice were reproduced using self-made steam scald appliance. The scald wounds were scanned with OCT 3 hours,or 3 and 8 days after injury respectively. Scanned wound tissue was harvested for histological examination right after each episode of OCT imaging. Normal skin of mice was scanned and examined with the abovementioned methods at the same time. Results Compared with those of the normal skin, collagen in the dermis was denatured ...
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    20. Evaluation of methylprednisolone aceponate, tacrolimus and combination thereof in the psoriasis plaque test using sum score, 20-MHz-ultrasonography and optical coherence tomography.

      Evaluation of methylprednisolone aceponate, tacrolimus and combination thereof in the psoriasis plaque test using sum score, 20-MHz-ultrasonography and optical coherence tomography.
      Background: Despite new treatment options with systemic disease modifiers, topical therapy – especially as combination therapy – plays an important role in psoriasis treatment. Methods: Antipsoriatic efficacy of methylprednisolone aceponate ointment (MPA), tacrolimus 0.1% ointment (FK506) and their combination (MPA+FK506) were investigated in a double-blind randomized pilot study using the psoriasis plaque test. Agents and corresponding placebos were applied once daily under occlusion for 11 days. Test sites were evaluated by sum score (erythema, scaling, infiltration), objective assessment by 20-MHz-sonography and optical coherence tomography (OCT). Results: After 11 days, the sum score significantly improved from baseline value in FK506-treated skin ...
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    21. OCT skin cancer trials to expand next year

      OCT skin cancer trials to expand next year
      A handheld optical coherence tomography (OCT) device could soon be helping clinicians to visualize and map the hidden spread of non-melanoma skin cancer (NMSC) under the skin. That’s according to UK-based medical equipment firm Michelson Diagnostics, which has just secured an additional £1.7 million in venture capital funding to expand its clinical trials program and support the commercialization of its VivoSight product. “We believe that VivoSight will enable substantial improvements in the efficiency of NMSC treatment,” Michelson’s CEO Jon Holmes told optics.org. “Current clinical practice for NMSC is to assess a suspicious lesion by eye. A ...
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    22. Feature Of The Week 11/13/10: Researchers from Queen's University in Belfast use OCT to Study of the Effects of Microneedle Geometry on Skin Penetration and Drug Delivery

      Feature Of The Week 11/13/10: Researchers from Queen's University in Belfast use OCT to Study of the Effects of Microneedle Geometry on Skin Penetration and Drug Delivery
      Feature Of The Week 11/13/10: Researchers from Queen’s University in Belfast have used optical coherence tomography (OCT) to extensively investigate, for the first time, the effect that microneedle (MN) geometry (MN height, and MN interspacing) and force of application have upon penetration characteristics of soluble poly(methyl vinyl ether-co-maleic anhydride, PMVE/MA) MN arrays into neonatal porcine skin in vitro. The results from OCT investigations were then used to design optimal and suboptimal MN-based drug delivery systems and evaluate their drug delivery profiles cross full thickness and dermatomed neonatal porcine skin in vitro. It was found that ...
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    23. Monitoring the process of tissue healing of rat skin in vivo after laser irradiation based on optical coherence tomography

      Monitoring the process of tissue healing of rat skin in vivo after laser irradiation based on optical coherence tomography
      It is imperative to evaluate the tissue wound healing response after laser irradiation so as to develop effective devices for this clinical indication, and evaluate the thermal damage degree to take appropriate treatment. In our research, we prepare 6 white rat (approximately 2 months old, weight :28±2g). Each rat was injected intraperitoneally a single dose of 2% pentobarbital sodium. After the rat was anesthetized, the two side of the rats' back were denuded and antisepsised a standardized. An Er:YAG laser (2940nm, 2.5J/cm2, single spot, 4 times) was irradiated on rat skin in vivo, and the skin ...
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    24. Monitoring collagen remodeling on opto-thermal response of photoaged skin irradiated by Er:YAG laser with optical coherence tomography

      Monitoring collagen remodeling on opto-thermal response of photoaged skin irradiated by Er:YAG laser with optical coherence tomography

      The Optical Coherence Tomography technology was used to perform noninvasive cross-sectional imaging of internal structures in photoaged mouse skin irradiated by Er:YAG laser. The mice were irradiated chronically with a steady dose of ultraviolet irradiation. Various laser light doses were irradiated on the back skins of the photoaged mouse. An OCT was used to observe the process of the collagen remodeling in dermis. The relationship between optical characteristic parameter such as attenuation coefficient and light dose was discovered. The total attenuation coefficient increased when the light dose increased. Our findings showed that Er:YAG laser could be used for ...

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