1. Articles in category: Dermatology

    265-288 of 465 « 1 2 ... 9 10 11 12 13 14 15 ... 18 19 20 »
    1. Optical coherence tomography-guided photodynamic therapy for skin cancer: Case series

      Optical coherence tomography-guided photodynamic therapy for skin cancer: Case series
      Background: Guiding and monitoring treatment during and after photodynamic therapy (PDT) of skin cancer is often difficult. Objectives: We investigated the applicability of in vivo optical coherence tomography (OCT) in guiding and monitoring PDT in patients with skin cancer.
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    2. Qualitative optical coherence tomography for normal and pathologic skin lesions

      Qualitative optical coherence tomography for normal and pathologic skin lesions
      The pre-clinical application of optical coherence tomography (OCT) on ex vivo skin lesions has validated this tool structurally and metrically. However, knowledge of in vivo normal and pathological skin architectural and morphological properties would be of significant interest in dermatological practice.
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    3. Diagnostic Devices Market to Grow 7.3% Annually Through 2015

      Diagnostic Devices Market to Grow 7.3% Annually Through 2015
      ROCKVILLE, MD--(Marketwire - Apr 19, 2011) - MarketResearch.com has announced the addition of MarketsandMarkets's new report "Worldwide Dermatology Devices Market (2010 - 2015)," to their collection of Therapeutic Area market reports. For more information, visit http://www.marketresearch.com/product/display.asp?ProductID=6221051 The dermatology devices studied and segmented in this report are as per their usage in the diagnosis and treatment of skin related disorders such as skin cancer (melanoma and non-melanoma), psoriasis, acne, scars, and others. The diagnostic devices analyzed are dermatoscopes, microscopes, imaging techniques such as MRI, CT and Optical Coherence Tomography (OCT) scanners. The total ...
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    4. Application of optical methods to characterize textile materials and their influence on the human skin

      Application of optical methods to characterize textile materials and their influence on the human skin

      The skin is not only the largest organ of the human body, but it is also a barrier to the environment. The major part of the human skin is in constant contact with textile materials. The objective of this study was to characterize textile materials and to investigate their influence on the skin properties. For this purpose, two different textile materials (polyamide and polyester) were objectively characterized by optical coherence tomography and surface structure 3D-profilometry. In addition, subjective textile properties like haptic sensation and stiffness, as tactile characteristics felt by volunteers, were analyzed. The objective textile characteristics and subjective parameters ...

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    5. OCT mapping tracks skin cancer during PDT

      OCT mapping tracks skin cancer during PDT
      OCT mapping tracks skin cancer during PDT A case study at University College Hospital London has demonstrated the successful use of optical coherence tomography (OCT) for in vivo mapping of non-melanoma skin cancer during photodynamic therapy (PDT). PDT provides a non-invasive alterative to surgical excision for non-melanoma skin cancers. But as no tissue is removed for analysis, it can be difficult to ensure all the tumour is treated. This work showed that the use of OCT (the VivoSight from Michelson Diagnostics) to image skin before, during and after PDT, could solve this problem (Photodiagnosis and Photodynamic Therapy 8 49).
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    6. In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT)

      In vivo imaging of the microcirculation of the volar forearm using correlation mapping optical coherence tomography (cmOCT)
      Correlation mapping optical coherence tomography (cmOCT) is a recently proposed technique that extends the capabilities of OCT to enable mapping of vasculature networks. The technique is achieved as a processing step on OCT intensity images that does not require any modification to existing OCT hardware. In this paper we apply the cmOCT processing technique to in vivo human imaging of the volar forearm. We illustrate that cmOCT can produce maps of the microcirculation that clearly follow the accepted anatomical structure. We demonstrate that the technique can extract parameters such as capillary density and vessel diameter. These parameters are key clinical ...
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    7. The global dermatology devices market is expected to grow at a CAGR of 7.3% from 2010 to 2015

      The global dermatology devices market is expected to grow at a CAGR of 7.3% from 2010 to 2015
      Worldwide Dermatology Devices Market (2010 - 2015) - The dermatology devices studied and segmented in this report are as per their usage in the diagnosis and treatment of skin related disorders such as skin cancer (melanoma and non-melanoma), psoriasis, acne, scars, and others. The diagnostic devices analyzed are dermatoscopes, microscopes, imaging techniques such as MRI, CT and Optical Coherence Tomography (OCT) scanners. The total market for diagnostic devices was estimated to be $175 million in 2010, and is expected to grow at a CAGR of 7.3% from 2010 to 2015.
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    8. Dermal reflectivity determined by optical coherence tomography is an indicator of epidermal hyperplasia and dermal edema within inflamed skin

      Dermal reflectivity determined by optical coherence tomography is an indicator of epidermal hyperplasia and dermal edema within inflamed skin
      Psoriasis is a common inflammatory skin disease resulting from genetic and environmental alterations of cutaneous immune responses. While numerous therapeutic targets involved in the immunopathogenesis of psoriasis have been identified, the in vivo dynamics of inflammation in psoriasis remain unclear. We undertook in vivo time course focus-tracked optical coherence tomography (OCT) imaging to noninvasively document cutaneous alterations in mouse skin treated topically with Imiquimod (IMQ), an established model of a psoriasis-like disease. Quantitative appraisal of dermal architectural changes was achieved through a two parameter fit of OCT axial scans in the dermis of the form A(x, y, z) = ρ ...
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    9. First published application of Optical Coherence Tomography for in vivo mapping of non-melanoma skin cancer

      First published application of Optical Coherence Tomography for in vivo mapping of non-melanoma skin cancer
      Michelson Diagnostics Press Release: A case study performed at University College Hospital London documenting the successful use of Michelson Diagnostics’ VivoSight OCT scanner for in vivo mapping of non-melanoma skin cancer, has been published in the March 2011 issue of Photodiagnosis and Photodynamic Therapy1.   The key benefit of Photodynamic Therapy (PDT) of non-melanoma skin cancers over conventional surgical excision is that it is non-invasive and therefore avoids surgery scars. This is a major advantage for the patient, because this type of skin cancer frequently occurs on the face, where disfiguring scars are highly undesirable. However, because no tissue is removed ...
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    10. In vivo three-dimensional optical coherence elastography

      In vivo three-dimensional optical coherence elastography
      Abstract: We present the first three-dimensional (3D) data sets recorded using optical coherence elastography (OCE). Uni-axial strain rate was measured on human skin in vivo using a spectral-domain optical coherence tomography (OCT) system providing >450 times higher line rate than previously reported for in vivo OCE imaging. Mechanical excitation was applied at a frequency of 125 Hz using a ring actuator sample arm with, for the first time in OCE measurements, a controlled static preload. We performed 3D-OCE, processed in 2D and displayed in 3D, on normal and hydrated skin and observed a more elastic response of the stratum corneum ...
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    11. Automatic measurement of epidermal thickness from optical coherence tomography images using a new algorithm

      Automatic measurement of epidermal thickness from optical coherence tomography images using a new algorithm
      Background/purpose: Optical coherence tomography (OCT) is an imaging system that enables in vivo epidermal thickness (ET) measurement. In order to use OCT in large-scale clinical studies, automatic algorithm detection of the dermo-epidermal junction (DEJ) is needed. This may be difficult due to image noise from optical speckle, which requires specific image treatment procedures to reduce this. In the present work, a description of the position of the DEJ is given, and an algorithm for boundary detection is presented. Methods: Twenty-nine images were taken from the skin of normal healthy subjects, from five different body sites. Seven expert assessors were ...
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    12. A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers

      A clinical instrument for combined raman spectroscopy-optical coherence tomography of skin cancers

      Background and Objective The current standard for diagnosis of skin cancers is visual inspection followed by biopsy and histopathology. This process can be invasive, subjective, time consuming, and costly. Optical techniques, including Optical Coherence Tomography (OCT) and Raman Spectroscopy (RS), have been developed to perform non-invasive characterization of skin lesions based on either morphological or biochemical features of disease. The objective of this work is to report a clinical instrument capable of both morphological and biochemical characterization of skin cancers with RS-OCT. Materials and Methods The portable instrument utilizes independent 785 nm RS and 1,310 nm OCT system backbones ...

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    13. Dr Stephen Matcher Biomedical Imaging Expert Seconded to Michelson Diagnostics

      Dr Stephen Matcher Biomedical Imaging Expert Seconded to Michelson Diagnostics
      Michelson Diagnostics Press Release -  Dr Stephen Matcher, Senior Lecturer in Biomedical Engineering at the Department of Materials Science and Engineering at the University of Sheffield, has been seconded to Orpington, UK-based start-up Michelson Diagnostics Ltd for 6 months, to provide the company with the benefits of his expertise in Optical Coherence Tomography (OCT), an advanced technique for skin imaging used in their products.   The secondment is enabled by a grant from the Royal Academy of Engineering (RAE) Industrial Secondment Scheme. This scheme is intended to help companies gain access to highly qualified academic expertise and to build links with universities ...
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    14. Octopus increases stake in cancer imaging firm, Michelson Diagnostics Ltd., with £300k investment

      Octopus increases stake in cancer imaging firm, Michelson Diagnostics Ltd., with £300k investment
      Michelson Diagnostics Press Release - A second investment of £300k into Michelson Diagnostics (‘Michelson’) has been made by Octopus Investments (‘Octopus’). This adds to the initial investment of £1.7M in October 2010 by Octopus into Michelson, the medical equipment and scanner specialists, whose unique laser scanning technology can image skin and other surface tissue at a much higher resolution than ever before. Michelson anticipates that the VivoSight scanner could revolutionise the treatment of non-melanoma skin cancer, by providing dermatologists with a new way of seeing abnormalities that are hidden below the skin surface.    The VivoSight scanner has already won CE ...
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    15. Monitoring skin photodamage using quantitative optical coherence tomography

      Monitoring skin photodamage using quantitative optical coherence tomography
      Noninvasive, real-time imaging technology assists UV light therapy of skin diseases and facilitates reduction of the associated photodamage. In clinical medicine, 8-methoxypsoralen (8-MOP) combined with ultraviolet A (UVA; 320–400nm) (PUVA) therapy is an effective and widely used treatment for several types of dermatose, including psoriasis, mycosis fungoides, and vitiligo. However, many studies have shown that PUVA has both potent mutagenic and carcinogenic effects and also immunosuppressive consequences. The latter can allow tumor development or changes to the immune function in both immuno-suppressed and healthy individuals.1,2 Long-term PUVA therapy significantly increases the risk of skin-cancer development.3,4
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    16. State of the art in non-invasive imaging of cutaneous melanoma

      State of the art in non-invasive imaging of cutaneous melanoma
      Background: This review focuses on looking at recent developments in the non-invasive imaging of skin, in particular at how such imaging may be used at present or in the future to detect cutaneous melanoma. Methods: A MEDLINE search was performed for papers using imaging techniques to evaluate cutaneous melanoma, including melanoma metastasis. Results: Nine different techniques were found: dermoscopy, confocal laser scanning microscopy (including multiphoton microscopy), optical coherence tomography, high frequency ultrasound, positron emission tomography, magnetic resonance imaging, and Fourier, Raman, and photoacoustic spectroscopies. This review contrasts the effectiveness of these techniques when seeking to image melanomas in skin. Conclusions ...
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    17. A New High-Resolution Method for Imaging Below the Skin using a Liquid Lens

      A New High-Resolution Method for Imaging Below the Skin using a Liquid Lens
      University of Rochester optics professor Jannick Rolland has developed an optical technology that provides unprecedented images under the skin's surface. The aim of the technology is to detect and examine skin lesions to determine whether they are benign or cancerous without having to cut the suspected tumor out of the skin and analyze it in the lab. Instead, the tip of a roughly one-foot-long cylindrical probe is placed in contact with the tissue, and within seconds a clear, high-resolution, 3D image of what lies below the surface emerges. Rolland will be presenting her findings at the 2011 annual meeting ...
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    18. Optical coherence tomography-guided photodynamic therapy for skin cancer: Case study

      Optical coherence tomography-guided photodynamic therapy for skin cancer: Case study
      Photodynamic therapy (PDT) has been identified as a successful therapy for skin cancer. This case study investigates the role of optical coherence tomography (OCT) in lesion (squamous cell carcinoma) mapping, assisting the surgeon to correctly deliver PDT and monitor the outcome. Optical coherence tomographic images were acquired pre-treatment to assess tumour extent and margins to enable guidance of the PDT. Tomographic images taken post-PDT up to 6 months revealed complete response to the treatment and no recurrence. OCT-guided PDT is one of the promising approaches to efficiently discriminate between tumor involved and noninvolved margins. It reduces the untoward healthy tissue ...
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    19. In vivo response of GsdmA3Dfl/+ mice to topically applied anti-psoriatic agents: effects on epidermal thickness, as determined by optical coherence tomography and H&E staining.

      In vivo response of GsdmA3Dfl/+ mice to topically applied anti-psoriatic agents: effects on epidermal thickness, as determined by optical coherence tomography and H&E staining.

      This study evaluated in vivo the potential of optical coherence tomography (OCT) to determine changes in thickness of the epidermis in response to the topically applied anti-psoriatics betamethasone dipropionate (BD), salicylic acid (SA) and also fish oil (FO). GsdmA3Dfl/+ mice have an inflammatory hair loss phenotype that includes hyperproliferation and epidermal thickening, hence a potential psoriasis model. Changes in epidermal thickness were evaluated over a period of 10 days, with the mice treated with combined BD + SA, FO + SA and BD + FO + SA. The data were validated with conventional measurement using H&E staining coupled with microscopy. Initial baseline measurement ...

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    20. Michelson Diagnostics Recruits Sales & Marketing Manager

      Michelson Diagnostics Recruits Sales & Marketing Manager
      Michelson Diagnostics Press Release - Skin cancer imaging firm Michelson Diagnostics Ltd has recruited Patrick Finnemore as Sales & Marketing Manager, UK & Europe. Patrick brings 25 years sales and marketing experience in the medTech industry. During his career Patrick has launched and commercialised a wide range of innovative high technology products for both large organisations and start-ups. Patrick started his career in marketing at Smith and Nephew where he was responsible for managing a portfolio of woundcare products. He subsequently worked at Baxter International and ConvaTec in a range of business management and international marketing roles.    In recent years he has worked ...
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    21. In Vivo Comparison of the Optical Clearing Efficacy of Optical Clearing Agents in Human Skin by Quantifying Permeability Using Optical Coherence Tomography

      In Vivo Comparison of the Optical Clearing Efficacy of Optical Clearing Agents in Human Skin by Quantifying Permeability Using Optical Coherence Tomography

      The objective of the present work is to quantify and compare the optical clearing efficacy of glucose, propylene glycol, glycerol solutions through the human skin tissue in vivo by calculating permeability coefficient of three solutions. Currently, the permeability coefficient of agent in tissues was extracted from OCT amplitude data mainly through the OCT signal slope (OCTSS) and the OCT amplitude (OCTA) methods. In this study, we report the OCT attenuation coefficient (OCTAC) method which is relatively novel and rarely reported methodology to measure the permeability coefficient during the optical skin clearing procedure. The permeability coefficients for 40% propylene glycol, glucose ...

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    22. In-vivo assessment of cleavage line orientation in human skin using optical coherence tomography

      In-vivo assessment of cleavage line orientation in human skin using optical coherence tomography
      Collagen and elastin fibers are generally arranged in parallel bundles within the dermis. These bundles are oriented such that they can most efficiently resist the stress and strain that normally occurs on the skin during movement. The pattern of these fiber bundles establishes the lines of cleavage of the skin. Knowledge of the orientation of these is of key importance for surgical procedures. When incisions are cut parallel to the cleavage line orientation the incision will heal better and produce less scaring. In this work we report a novel application of Optical coherence tomography for the determination of cleavage line ...
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    23. Michelson Diagnostics Expands

      Michelson Diagnostics Expands
      Michelson Diagnostics Press Release - Skin cancer imaging firm Michelson Diagnostics Ltd has announced that it is expanding its UK headquarters by leasing a 900 ft2 office suite. “Our requirements for more space to accommodate our growing manufacturing operations, research & development, and sales administration have resulted in a doubling of our premises area roughly every 18 months since we founded Michelson Diagnostics in 2006”, said Operations Director and co-Founder Martin Johns. “This trend looks set to continue in 2011 and beyond, as we are making excellent progress towards our business goals. For example, we plan to lease premises in the USA ...
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    24. Clinical application of optical coherence tomography for the imaging of non-melanocytic cutaneous tumors: a pilot multi-modal study

      Clinical application of optical coherence tomography for the imaging of non-melanocytic cutaneous tumors: a pilot multi-modal study
      Context: Optical coherence tomography (OCT) is an emergent imaging technique, based on the interference of infrared radiation and living tissues, that allows the in vivo visualization of the skin structures, at high resolution and up to 1.6 mm depth. As such, there is mounting evidence that OCT may be an interesting technique for the diagnosis of skin diseases, including the non-invasive early detection of cutaneous tumors. Objective: We aimed to investigate the utility of OCT for the diagnosis of non-melanocytic, non-pigmented cutaneous tumors. Methods: Preliminary results are presented from an initiated study. Fifteen consecutive patients with clinical suspicion of ...
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