1. Articles in category: Dermatology

    265-288 of 647 « 1 2 ... 9 10 11 12 13 14 15 ... 25 26 27 »
    1. High-definition optical coherence tomography imaging of melanocytic lesions: a pilot study

      High-definition optical coherence tomography imaging of melanocytic lesions: a pilot study

      High-definition optical coherence tomography (HD-OCT) is a non-invasive in vivo imaging technique with cellular resolution based on the principle of conventional optical coherence tomography. The objective of this study was to evaluate HD-OCT for its ability to identify architectural patterns and cytologic features of melanocytic lesions. All lesions were examined by one observer clinically and using dermoscopy. Cross-sectional HD-OCT images were compared with histopathology. En face HD-OCT images were compared with reflectance confocal microscopy (RCM). Twenty-six melanocytic lesions of 26 patients were imaged. Identification of architectural patterns in cross-sectional mode and cytologic features of pigmented cells in the epidermis, dermo-epidermal ...

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    2. Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus

      Morphological changes in skin of different phototypes under the action of topical corticosteroid therapy and tacrolimus

      Background/purpose The present study aimed to investigate the influence of topical corticosteroid therapy and tacrolimus on morphological indices of different skin phototypes and to optimize topical therapy using the OCT technique. Methods Twenty healthy volunteers aging from 20 to 30 (14 men and 6 women) took part in the study: 10 persons with skin phototype I, II and 10 persons with skin phototype V, VI. Morphological state of the skin was assessed before and during application of topical steroids of different strength and calciumneurin inhibitors for 49 days. Morphological state was studied in vivo using the optical coherence tomograph ...

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    3. Optical coherence tomography: What is optical coherence tomography?

      Optical coherence tomography:  What is optical coherence tomography?

      Optical coherence tomography (OCT) is a non-invasive optical imaging technique that uses low-power infrared laser light to image up to 2 mm beneath the skin surface. The clinician can obtain real-time images of the architecture of the skin without pretreatment or gels. OCT has been shown to be a useful diagnostic tool in diagnosing early stage skin cancer [1]. What lies beneath the skin surface can be seen in vivo, without the need for skin biopsy [2]. Studies have compared OCT findings with histopathology, establishing the OCT characteristics of actinic keratoses , in-situ squamous cell carcinoma (SCC), and basal cell carcinoma ...

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    4. Optical Coherence Tomography for presurgical margin assessment of non‐melanoma skin cancer‐a practical approach

      Optical Coherence Tomography for presurgical margin assessment of non‐melanoma skin cancer‐a practical approach

      Background In the clinical setting, OCT is applicable for the non-invasive diagnosis of skin cancer and may in particular be used for margin definition prior to excision. In this regard, OCT may improve the success rate of removing tumor lesions more effectively, preventing repetitive excision, which may subsequently result in smaller excisions. Objective In this study we have aimed to evaluate the applicability of OCT for in-vivo presurgical margin assessment of non-melanocytic skin tumors (NMSC) and to describe the feasibility of different scanning techniques. Material and methods A total number of 18 patients planned for excision of lesions suspicious of ...

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    5. Dual-imaging system for burn depth diagnosis

      Dual-imaging system for burn depth diagnosis

      Currently, determination of burn depth and healing outcomes has been limited to subjective assessment or a single modality, e.g., laser Doppler imaging. Such measures have proven less than ideal. Recent developments in other non-contact technologies such as optical coherence tomography (OCT) and pulse speckle imaging (PSI) offer the promise that an intelligent fusion of information across these modalities can improve visualization of burn regions thereby increasing the sensitivity of the diagnosis. In this work, we combined OCT and PSI images to classify the degree of burn (superficial, partial-thickness and full-thickness burns). Algorithms were developed to integrate and visualize skin ...

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    6. Confocal laser scanning microscopy and optical coherence tomography for the evaluation of the kinetics and quantification of wound healing after fractional laser therapy

      Confocal laser scanning microscopy and optical coherence tomography for the evaluation of the kinetics and quantification of wound healing after fractional laser therapy

      Background Information on the course of wound healing after fractional carbon-dioxide laser therapy has so far been gathered by histopathology. Confocal laser scanning microscopy (CLSM) and optical coherence tomography (OCT) allow the visualization of the upper layers of the skin in vivo over time. Objective The aim of this study was to determine whether CLSM and OCT can be used to quantify the kinetics of the dynamic wound-healing process. Methods Twenty healthy probands were treated with fractional carbon-dioxide laser with 8- and 16-W laser power, respectively. Optical follow-ups using CLSM and OCT were performed right after laser application and during ...

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    7. Evaluation of optical coherence tomography as a non-invasive diagnostic tool in cutaneous wound healing

      Evaluation of optical coherence tomography as a non-invasive diagnostic tool in cutaneous wound healing

      Background The monitoring of wound-healing processes is indispensable for the therapeutic effectiveness and improved care of chronic wounds. Histological sections provide the best morphological assessment of wound recovery, but cause further tissue destruction and increase the risk of infection. Therefore, it is reasonable to apply a diagnostic tool that allows a non-invasive and reliable observation of morphological changes in wound healing. Methods Optical coherence tomography (OCT) is an imaging technique for in vivo evaluation of skin diseases with a resolution close to histopathology. The aim of this study was to investigate whether OCT is suited to display the phases of ...

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    8. PhD Studentship in High Speed 3D Studies of the Biomechanics of Skin Friction at University of Sheffield

      PhD Studentship in High Speed 3D Studies of the Biomechanics of Skin Friction at University of Sheffield

      This PhD will support a recently funded EPSRC project which is being carried out in the Departments of Mechanical Engineering and Materials Science and Engineering, centred on improving our understanding of skin friction. Skin plays many vital roles in the health of the body. One area that has received less attention than others is its function in providing required levels of friction. Factors determining skin friction are relevant to areas such as medicine, sports science, rehabilition engineering, cosmetics and consumer lifestyle. Insufficient friction contributes to difficulties experienced by the elderly in gripping objects. Excessive friction can lead to discomfort, chaffing ...

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    9. Acute skin lesions following psoralen plus ultraviolet A radiation investigated by optical coherence tomography

      Acute skin lesions following psoralen plus ultraviolet A radiation investigated by optical coherence tomography

      Psoralen plus ultraviolet A radiation (PUVA) therapy is a very important clinical treatment of skin diseases such as vitiligo and psoriasis, but associated with an increased risk of skin photodamage, especially photoaging. In this work, optical coherence tomography (OCT), a novel non-invasive imaging technology, was introduced to investigate in vivo the photodamage induced by PUVA qualitatively and quantitatively. Balb/c mouse dorsal skin was treated with 8-methoxypsoralen (8-MOP), and then exposed to UVA radiation. OCT images of the tissues were obtained by an OCT system with a 1310 nm central wavelength. Skin thickness and the attenuation coefficient were extracted from ...

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    10. Michelson Diagnostics wins Regulatory Approval for VivoSight OCT Scanner in Australia

      Michelson Diagnostics wins Regulatory Approval for VivoSight OCT Scanner in Australia

      Michelson Diagnostics Press release: Michelson Diagnostics the UK based medical device company has been given regulatory approval by the Therapeutics Goods Administration (TGA) in Australia to start selling its market leading VivoSight OCT Scanner. Australia has the highest incidence of skin cancer in the world and the number of people needing treatment continues to grow. The Australian Institute of Health and Welfare and Cancer Australia estimates there were 430,000 new cases of Non-Melanoma Skin Cancer diagnosed in 2008. This is approximately four-fold higher than the number of new cases diagnosed in the UK. In a recent position statement, the ...

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    11. In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography

      In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography

      Background: Sarcoptes scabiei can be visualized with different imaging tools. Optical coherence tomography (OCT) may have the potential to describe the changes in skin morphology due to scabies infestation and visualize the parasite. Methods: Five patients from the Departments of Dermatology, Augsburg, Germany, and Roskilde, Denmark, were OCT scanned (VivoSight®; Michelson Diagnostics Ltd., UK). Mites were identified by epiluminescence and light microscopy to confirm the diagnosis. Results: OCT identified S. scabiei mites in all patients in vivo. Mites and burrows were visualized, and some detail on burrow content was provided. Conclusion: OCT can visualize S. scabiei mites in vivo, suggesting ...

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    12. Scattering imaging of skin in Fourier domain optical coherence tomography

      Scattering imaging of skin in Fourier domain optical coherence tomography

      A scattering imaging method for skin tissue in Fourier domain optical coherence tomography is proposed. In this method, parameter F image is obtained from the intensity signal as a function of the depth. Since parameter F contains only the scattering coefficient and its first order derivative, the scattering coefficient image depending on depth can be calculated from the parameter F image. Two-dimensional (2D) scattering coefficient images of palm skin are calculated after extracting the tissue interfaces in the 2D parameter F images.

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    13. Study shows VivoSight OCT could help Eyelid Cancer Surgery

      Study shows VivoSight OCT could help Eyelid Cancer Surgery

      Michelson Diagnostics Press Release - In what is believed to be the first ever study to investigate OCT (Optical Coherence Tomography) imaging of skin cancers in the eyelids and skin surrounding the eye, the Dept of Opthalmology, Maidstone and Tunbridge Wells NHS Trust have shown that OCT scanning can accurately reveal the margins of tumours. The study, which was conducted using the market leading VivoSight OCT scanner manufactured by Michelson Diagnostics, showed a positive correlation between tumour margins located using OCT and histology, the 'gold standard'. This breakthrough could ultimately lead to routine use of OCT scanning to plan delicate eyelid ...

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    14. Noninvasive characterization of fractional photothermolysis induced by ablative and non-ablativelasers with optical coherence tomography

      Noninvasive characterization of fractional photothermolysis induced by ablative and non-ablativelasers with optical coherence tomography

      In this study, an optical coherence tomography (OCT) system is implemented for the noninvasive characterization of photothermolysis in human skin induced by ablative fractional lasers (AFLs) and non-ablative fractional lasers (NAFLs). With OCT imaging, microthermal zones (MTZs) induced by fractional lasers can be noninvasively visualized, and the size of induced MTZs can be quantitatively evaluated. According to the OCT results, the center region of the induced MTZ corresponds to weaker backscattered intensity after the AFL exposure as a result of tissue volatilization by photon energy. In contrast, after the NAFL exposure, the skin tissue is damaged and coagulated but not ...

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    15. High-Definition Optical Coherence Tomography (HD-OCT)

      High-Definition Optical Coherence Tomography (HD-OCT)

      Munich Germany, Priv. Doz. Dr. Gerald Messer (Munich, Germany) makes use of an AGFA SKINTELL unit for test purpose. He is quite impressed about the new technologies performance, especially in diagnosis of non-melanoma skin cancer. A first test is so promising that a second closer look will be done with associated clinics in June. “The new High-Definition Optical Coherence Tomography (HD-OCT) technology will give the opportunity to diagnose actinic keratosis and basal cell carcinoma without intervention in an early stage where non-invasive therapies are promising”. Dr. Messer reported also some success from the DDG (Deutsche Dermatologische Gesellschaft) Congress that was ...

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    16. Interest of High Definition Optical Coherent Tomography (HD‐OCT) for imaging of melanoma

      Interest of High Definition Optical Coherent Tomography (HD‐OCT) for imaging of melanoma

      We read with interest two recent studies which established that High Definition Optical Coherent Tomography (HD-OCT), a newly released skin imaging technique, facilitates the in vivo diagnosis of non-melanoma skin cancers (1, 2). However, to the best of our knowledge there is no data available regarding HD-OCT and melanoma. A 61-year-old man, skin type II, with a previous history of melanoma 10 years before consulted for a follow-up visit. Clinical and dermoscopic examination pointed to two suspicious pigmented lesions in the right pectoral region and on the left scapula. RCM examination using a commercially available VivaScope ® 1500 (Lucid-Tech Inc., Henrietta ...

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    17. In vivo optical coherence tomography (OCT) in periocular basal cell carcinoma: correlations between in vivo OCT images and postoperative histology

      In vivo optical coherence tomography (OCT) in periocular basal cell carcinoma: correlations between in vivo OCT images and postoperative histology

      Aim To investigate in vivo optical coherence tomography (OCT) for imaging of periocular basal cell carcinoma (BCC). Methods Consecutive patients with periocular BCC were prospectively investigated with VivoSight OCT imaging prior to surgical excision. Histology sections were compared with OCT images with regard to lesion measurements (x, y and z dimensions) and histological features. Results A total of 15 patients with biopsy proven BCC were recruited. The OCT horizontal margins correlated positively with histology (r=0.8 and 0.66, x and y axes) and could be identified in 3/15 (x axis) and 6/15 (y axis) cases. The ...

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    18. Functional and structural age-related changes in the scalp skin of Caucasian women

      Functional and structural age-related changes in the scalp skin of Caucasian women

      Background Ageing of the skin, being chronological or sun induced is highly documented. Scalp, as a specific skin site, has, however, received little attention. This work attempted to describe functional and structural alterations that occur in scalp skin with ageing. Methods Two different age groups (N = 15 each; 30 ± 3 and 62 ± 2 y.o. respectively) of Caucasian women participated in the study. Some functional parameters (TEWL, Sebum level, Hydration, T°) were recorded on the vertex part of the scalp, after having cut the hair flat on the scalp surface. Imaging of some structural criteria was carried out using high-frequency ...

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    19. Calluses, Corns and Heel Fissures

      Calluses, Corns and Heel Fissures

      Hypertrophy of the plantar stratum corneum (SC) of the epidermis (also known as hyperkeratosis) is one of the skin's primary protective responses, triggered by either physiological stresses, a result of underlying disease (eg, psoriasis, palmoplantar keratoderma), or external mechanical stresses. In the case of the foot the most common presentations of hyperkeratosis are: anhidrosis, calluses, corns and heel fissures. This article reviews the current evidence in the field of hyperkeratosis of the foot and will present the treatment options available to practitioners and patients. The gaps in the knowledge surrounding the efficacy of treatments are discussed and novel methods ...

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    20. Feasibility of correlation mapping optical coherence tomography (cmOCT) for anti-spoof sub-surface fingerprinting

      Feasibility of correlation mapping optical coherence tomography (cmOCT) for anti-spoof sub-surface fingerprinting

      We propose the use of correlation mapping optical coherence tomography (cmOCT) to deliver additional biometrics associated with the finger that could complement existing fingerprint technology for law enforcement applications. The current study extends the existing fingerprint paradigm by measuring additional biometrics associated with sub-surface finger tissue such as sub-surface fingerprints, sweat glands, and the pattern of the capillary bed to yield a user-friendly cost effective and anti-spoof multi-mode biometric solution associated with the finger. To our knowledge no other method has been able to capture sub-surface fingerprint, papillary pattern and horizontal vessel pattern in a single scan or to show ...

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    21. Combined reflectance confocal microscopy/optical coherence tomography imaging for skin burn assessment

      Combined reflectance confocal microscopy/optical coherence tomography imaging for skin burn assessment

      A combined high-resolution reflectance confocal microscopy (RCM)/optical coherence tomography (OCT) instrument for assessing skin burn gravity has been built and tested. This instruments allows for visualizing skin intracellular details with submicron resolution in the RCM mode and morphological and birefringence modifications to depths on the order of 1.2 mm in the OCT mode. Preliminary testing of the dual modality imaging approach has been performed on the skin of volunteers with some burn scars and on normal and thermally-injured Epiderm FTTM skin constructs. The initial results show that these two optical technologies have complementary capabilities that can offer the ...

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    22. Positional differences and aging changes in Japanese woman epidermal thickness and corneous thickness determined by OCT (optical coherence tomography)

      Positional differences and aging changes in Japanese woman epidermal thickness and corneous thickness determined by OCT (optical coherence tomography)

      Background/purpose A number of studies of the internal structure of Japanese woman's skin are now performed by means of optical coherence tomography (OCT) as a technique capable of visualizing the internal structure in a non-invasive manner. Methods We measured the epidermal and corneous thicknesses at 11 sites in 116 healthy female volunteers aged from teens to sixties to examine possible positional differences and aging changes. Results The epidermal thickness determined at the 11 sites averaged 68.6 ± 23.0 μm (mean ± SD) and the corneous thickness averaged 14.1 ± 1.80 μm, the values of which were thinner ...

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      Mentions: Tetsuya Tsugita
    23. Optical coherence tomography: its role in daily dermatological practice

      Optical coherence tomography: its role in daily dermatological practice

      Optical coherence tomography (OCT) is a non-invasive, tomographic imaging technique which generates high-resolution in-vivo images up to mid-dermal layers. Due to continuous technological improvements, OCT is moving from research projects into daily dermatological practice. It can complement other imaging methods like high-frequency ultrasound or confocal microscopy. There is a wide variety of indications for OCT. In addition to aiding in the diagnosis and clinical monitoring of inflammatory dermatoses, OCT is a very useful and feasible technique in dermato-oncology.

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    24. Optical techniques for the noninvasive diagnosis of skin cancer

      Optical techniques for the noninvasive diagnosis of skin cancer

      Purpose The aim of this paper is to provide an overview of the most investigated optical diagnostic techniques: optical coherence tomography, fluorescence spectrometry, reflectance spectrometry, Raman spectroscopy, and confocal microscopy. Methods A search of three databases was conducted using specific keywords and explicit inclusion and exclusion criteria for the analysis of the performances of these techniques in the pre- and postoperative diagnosis of skin cancers. Results Optical coherence tomography has shown promising results in the assessment of deep margins of skin tumors and inflammatory skin diseases, but differentiating premalignant from malignant lesions proved to be less effective. Fluorescence spectroscopy proved ...

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