1. Articles in category: Dermatology

    265-288 of 369 « 1 2 ... 9 10 11 12 13 14 15 16 »

    1. OCT diagnostics: gathering the data

      Explore optics.org Dermatology , Oncology , Probes
      Clinical study to evaluate optical imaging for pre-operative diagnosis of early forms of skin cancer. Michelson Diagnostics, the UK manufacturer and developer of optical-coherence-tomography (OCT) imaging systems, has initiated an in vivo trial of its VivoSight multibeam OCT probe. At least 100 patients will be scanned as part of the initial early-stage study. The trial is a collaboration between researchers at Michelson and Ludwig Maximilians University in Munich, Germany. Together they're working to evaluate VivoSight's ability to differentiate premalignant and early malignant lesions, as well as to demarcate non-melanoma skin cancers before planned surgical excision. OCT is a ...
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      Mentions: Michelson Diagnostics Gordon Mckenzie Michelson Diagnostics Vivosight

    2. Skin Cancer Trials of Michelson Diagnostics’ VivoSight OCT Probe commence

      Explore Optical Coherence Tomography News Dermatology , Oncology , Other Business News
      Skin Cancer Trials of Michelson Diagnostics’ VivoSight OCT Probe commence
      Orpington, UK, July 29th, 2009: In-vivo trials of the Michelson Diagnostics’ VivoSight Multi-beam Optical Coherence Tomography (OCT) probe have begun. The trial, which is a collaboration between Michelson Diagnostics and Ludwig Maximilians University of Munich, will assess the capability of the pr
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      Mentions: Michelson Diagnostics Gordon Mckenzie Michelson Diagnostics Vivosight

    3. Clinical optical coherence tomography combined with multiphoton tomography of patients with skin diseases

      Explore www3.interscience.wiley.com Dermatology , Oncology

      We report on the first clinical study based on optical coherence tomography (OCT) in combination with multiphoton tomography (MPT) and dermoscopy. 47 patients with a variety of skin diseases and disorders such as skin cancer, psoriasis, hemangioma, connective tissue diseases, pigmented lesions, and autoimmune bullous skin diseases have been investigated with (i) state-of-the-art OCT systems for dermatology including multibeam swept source OCT, (ii) the femtosecond laser multiphoton tomograph, and (iii) dermoscopes. Dermoscopy provides two-dimensional color images of the skin surface. OCT images reflect modifications of the intratissue refractive index whereas MPT is based on nonlinear excitation of endogenous fluorophores and ...

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      Mentions: Michelson Diagnostics Gordon Mckenzie Julia Welzel

    4. Synthetic Skin Gets a Second Life

      Explore IEEE Spectrum Online Dermatology
      Synthetic Skin Gets a Second Life
      13 July 2009—Producing synthetic skin for grafts and testing the safety of drugs and chemicals is possible today, but it is a highly complex process requiring extensive manual work. A number of ventures that have tried to produce synthetic skin in large quantities have failed, largely due to a lack of automation in their manufacturing. But a team of scientists and engineers from several units of Germany’s Fraunhofer-Gesellschaft believe they can make engineered tissue widely available using a fully automated process they recently demonstrated.
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    5. Non-destructive detection of defects in artificial skin tissue by optical coherence tomography

      Explore SPIE Digital Library Dermatology , NDE/NDT
      The application of optical coherence tomography OCT in tissue engineering facilities offers great potential for the automated detection of defects or inhomogeneities in tissue products. This non-invasive and non-destructive measurement technique enables the high speed generation of two dimensional cross sections of tissue with micron resolution. The integration of an OCT device into a tissue production facility allows the monitoring and quality control of tissue engineering products. By the selective exclusion of tissue products with insufficient quality features a high degree in production standard is guaranteed. In a first study, OCT tomograms of artificial skin equivalents were acquired and compared ...
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    6. Which histological characteristics of basal cell carcinomas influence the quality of optical coherence tomography imaging?

      Explore SPIE Digital Library Dermatology , Oncology
      We explore how histopathology parameters influence OCT imaging of basal cell carcinomas (BCC) and address whether such parameters correlate with the quality of the recorded OCT images. Our results indicate that inflammation impairs OCT imaging and that sun-damaged skin can sometimes provide more clear-cut images of skin cancer lesions using OCT imaging when compared to skin cancer surrounded by skin without sun-damage.
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      Mentions: Thomas M. Jørgensen Technical University of Denmark (DTU) Lars Thrane

    7. OCT imaging of skin cancer and other dermatological diseases

      Explore www3.interscience.wiley.com Dermatology , Oncology
      Optical coherence tomography (OCT) provides clinicians and researchers with micrometer-resolution, in vivo, cross-sectional images of human skin up to several millimeter depth. This review of OCT imaging applied within dermatology covers the application of OCT to normal skin, and reports on a large number of applications in the fields of non-melanoma skin cancer, malignant melanomas, psoriasis and dermatitis, infestations, bullous skin diseases, tattoos, nails, haemangiomas, and other skin diseases
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      Mentions: Peter E. Andersen Thomas M. Jørgensen Technical University of Denmark (DTU)

    8. Single-shot two-dimensional full-range optical coherence tomography achieved by dispersion control

      Explore opticsinfobase.org Dermatology , Ophthalmology
      Single-shot two-dimensional full-range optical coherence tomography achieved by dispersion control
      We present a full-range Fourier-domain optical coherence tomography (OCT) system that is capable of acquiring two-dimensional images of living tissue in a single shot. By using line illumination of the sample in combination with a two-dimensional imaging spectrometer, 1040 depth scans are performed simultaneously on a sub-millisecond timescale. Furthermore, we demonstrate an easy and flexible real-time single-shot technique for full-range (complex-conjugate cancelled) OCT imaging that is compatible with both two-dimensional as well as ultrahighresolution OCT. By implementing a dispersion imbalance between reference and sample arms of the interferometer, we eliminate the complex-conjugate signal through numerical dispersion compensation, effectively increasing the ...
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      Mentions: VU University Amsterdam

    9. Assessment of the effects of ultrasound-mediated alcohols on skin optical clearing

      Explore SPIE Digital Library Dermatology
      Our previous studies have shown the ultrasound-induced skin optical clearing enhancement with topical application of glycerol on in vitro porcine skin and in vivo human skin. The objective of this study was to find more effective ultrasound-alcohol combinations on skin optical clearing. The effect of sonophoretic delivery (SP) in combination with a series of alcohols such as glycerol, propylene glycol, butanediol, butanol, polyethylene glycol (PEG200, PEG400) on skin optical clearing was investigated. Light transmittance and imaging depth of in vitro porcine skin were measured with spectroscopy and optical coherence tomography (OCT). Sixty percent alcohols and ultrasound (SP) with a frequency ...
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    10. Skin from various ethnic origins and aging: an in vivo cross-sectional multimodality imaging study

      Explore www3.interscience.wiley.com Dermatology
      Ethnic differences in skin structural features have not been thoroughly investigated, and the few reported studies are contradictory. Thus, we have carried out a set of in vivo measurements on the skin of about 400 volunteers from various ethnic origins living in the same environment. Female subjects were distributed into four ethnic groups: African Americans, Mexicans, Caucasians, and Chinese. Inter- and intra-ethnic skin structural differences, according to age and anatomic site, were investigated using three non-invasive skin-imaging methods: ultrasound (US) at 25 and 150 MHz, and optical coherence tomography (OCT). The thickness of the skin is higher on the cheek ...
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    11. The characteristics of three-dimensional skin imaging system by full-colored optical coherence tomography

      Explore SpringerLink Home Dermatology
      Abstract In the present cosmetic market, the skin image obtained from a hand-held camera is two-dimensional (2-D). Due to insufficient penetration, only the skin surface can be detected, and thus phenomena in the dermis cannot be observed. To take the place of the conventional 2D camera, a new hand-held imaging system is proposed for three-dimensional (3-D) skin imaging. Featuring non-invasiveness, optical coherence tomography (OCT) has become one of the popular medical imaging techniques. The dermal images shown in OCT-related reports were mainly single-colored because of the use of a monotonic light source. With three original-colored beams applied in OCT, a ...
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    12. Noninvasive and High-resolution Optical Monitoring of Healing of Diabetic Dermal Excisional Wounds Implanted with Biodegradable in situ Gelable Hydrogels

      Explore Mary Ann Liebert, Inc. Dermatology
      Closure of diabetic dermal chronic wounds remains a clinical challenge. Implant-assisted healing is emerging as a potential class of therapy for dermal wound closure; this advancement has not been paralleled by the development in complementary diagnostic techniques to objectively monitor the wound healing process in conjunction with assessing/monitoring of implant efficacy. Biopsies provide the most objective morphological assessments of wound healing; however, they not only perpetuate the wound presence but also increase the risk of infection. A non-invasive and high-resolution imaging technique is highly desirable to provide objective longitudinal diagnosis of implant-assisted wound healing. We investigated the feasibility of ...
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      Mentions: Yingtian Pan SUNY at Stony Brook

    13. OCT of healthy skin, actinic skin and BCC lesions

      Explore ScienceDirect Dermatology , Oncology
      Objective For the differentiation between healthy skin and actinic and BCC lesions two-dimensional images of the skin structure in situ might be of certain value. Optical coherence tomography (OCT) was used to assess whether the OCT images be of particular value or could act as a projection frame of further information obtained by various other methods, e.g. spatially resolved fluorescence detection (SRFD). Material and methods Images of healthy skin, actinic skin lesions with different degrees of dysplasia, and basal cell carcinoma (BCC) lesions were obtained from 10 patients referred for local photodynamic therapy (PDT). These were compared with regard ...
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      Mentions: Thorlabs Maria Ziolkowska Carsten M. Philipp

    14. The electromagnetic response of human skin in the millimetre and submillimetre wave range

      Explore Institute of Physics Dermatology
      Recent studies of the minute morphology of the skin by optical coherence tomography revealed that the sweat ducts in human skin are helically shaped tubes, filled with a conductive aqueous solution. This, together with the fact that the dielectric permittivity of the dermis is higher than that of the epidermis, brings forward the supposition that as electromagnetic entities, the sweat ducts could be regarded as low Q helical antennas. The implications of this statement were further investigated by electromagnetic simulation and experiment of the in vivo reflectivity of the skin of subjects under varying physiological conditions (Feldman et al 2008 ...
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      Mentions: Andreas Caduff Solianis Monitoring AG

    15. Assessment of Optical Coherence Tomography Imaging in the Diagnosis of Non-Melanoma Skin Cancer and Benign Lesions Versus Normal Skin: Observer-Blinded Evaluation by Dermatologists and Pathologists

      Explore www3.interscience.wiley.com Dermatology , Oncology
      BACKGROUND Optical coherence tomography (OCT) is an optical imaging technique that may be useful in diagnosis of non-melanoma skin cancer (NMSC). OBJECTIVES To describe OCT features in NMSC such as actinic keratosis (AK) and basal cell carcinoma (BCC) and in benign lesions and to assess the diagnostic accuracy of OCT in differentiating NMSC from benign lesions and normal skin. METHODS AND MATERIALS OCT and polarization-sensitive (PS) OCT from 104 patients were studied. Observer-blinded evaluation of OCT images from 64 BCCs, 1 baso-squamous carcinoma, 39 AKs, two malignant melanomas, nine benign lesions, and 105 OCT images from perilesional skin was performed ...
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      Mentions: Thomas M. Jørgensen Technical University of Denmark (DTU) Lars Thrane

    16. Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy

      Explore SPIE Digital Library Dermatology , Oncology
      We describe an application of plasmonic silica/gold nanoshells to produce a controllable laser hyperthermia in tissues with the aim of the enhancement of cancer photothermal therapy. Laser irradiation parameters are optimized on the basis of preliminary experimental studies using a test-tube phantom ... [J. Biomed. Opt. 14, 021016 (2009)] published Mon Apr 27, 2009.
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      Mentions: Institute of Applied Physics Saratov State University Valery V. Tuchin

    17. Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study

      Explore SPIE Digital Library Dermatology
      Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study
      The effect of silica/gold nanoshells and titanium dioxide nanoparticles on the optical properties of skin is studied. By implementing in vivo measurements and Monte Carlo simulations, we analyze the efficiency of using these nanoparticles as contrasting agents for optical coherence tomography (OCT) imaging of skin. In vivo measurements are performed on pig skin, where nanoparticle suspension drops have been applied. The identification of skin layers is performed by comparison with corresponding histology images. Experimental results exhibit an increase in contrast of the obtained OCT images after a single nanoparticles application. Multiple applications do not lead to increase in the ...
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      Mentions: Nizhny Novgorod State Medical Academy Institute of Applied Physics Elena V. Zagaynova

    18. Optical coherence tomography: A potential tool for unsupervised prediction of treatment response for Port-Wine Stains

      Explore ScienceDirect Dermatology
      Background: Treatment of Port-Wine Stains (PWS) suffers from the absence of a reliable real-time tool for monitoring a clinical endpoint. Response to treatment varies substantially according to blood vessel geometry. Even though optical coherence tomography (OCT) has been identified as a modality with potential to suit this need, it has not been introduced as a standard clinical monitoring tool. One reason could be that – although OCT acquires data in real-time – gigabyte data transfer, processing and communication to a clinician may impede the implementation as a clinical tool. Objectives: We investigate whether an automated algorithm can address this problem. Methods: Based ...
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      Mentions: Gloucestershire Royal Hospital Nick Stone Florian Bazant-Hegemark

    19. Technology Testing Update Including Recent in vivo University Study Results

      Explore smh.com.au Dermatology
      Newly developed Cell OCT, an approach to full-field optical coherence tomography, has enabled researchers to image breast-cancer tissue with histology-like results. Full-field OCT is an en face (transverse), broadband interferometric approach to optical coherence tomography (OCT) that’s been in use for life-science research for more than a decade.1–3 The technique offers many advantages, including fast tissue imaging at the cellular level, which is why at ESPCI (Ecole Superieure Physique Chimie Industrielles; Paris, France) we call it “Cell OCT.” Recently, full-field Cell OCT proved able to virtually slice ablated breast tumors and lymph nodes with 1 µm isotropic ...
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      Mentions: University of Queensland David D. Sampson University of Western Australia

    20. Dermal scatter reduction in human skin: A method using controlled application of glycerol

      Explore www3.interscience.wiley.com Dermatology

      Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients.After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures.Topically applied glycerol increased light penetration of in vivo corneal-stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve ...

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      Mentions: BioTex Incorporated Massoud Motamedi University of Texas Medical Branch

    21. Bioengineering of the Skin: Skin Imaging and Analysis, Second Edition (Book)

      Explore catalogue.informahealthcare.com Dermatology , Textbooks
      Bioengineering of the Skin: Skin Imaging and Analysis, Second Edition (Book)
      Spanning the many advancements that have taken place in the field since the first edition of this book was published, this second edition emphasizes the imaging of the skin in its entirety, rather than focusing solely on surface layers. The Second Edition includes new chapters on technologies such as in vivo confocal laser scanning microscopy, Raman spectroscopy, optical coherence tomography, nuclear magnetic imaging, high-resolution ultrasound, in vivo skin topometry and multi-photon imaging of the skin.
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    22. Feature Of The Week 3/22/09: Increased Penetration Depth in Optical Coherence Tomography using Hyper-Osmotic Agents

      Explore Optical Coherence Tomography News Dermatology
      Feature Of The Week 3/22/09: Increased Penetration Depth in Optical Coherence Tomography using Hyper-Osmotic Agents
      Feature Of The Week 3/22/09: Penetration depth has always been an Achilles’ heel for OCT. Ophthalmologists have enjoyed the transparency of the eye to allow high efficiency transmission of light to and from the retina. For other applications such as dermatology the strong light scattering of surface skin represents a fundamental challenge. There have been numerous studies on methods to increase penetration depth including optical clearing agents and mechanical techniques. One technique being investigated at Nankai University by Xiaonong Zhu et al is the use of hyper-osmotic agents. Shown here are OCT images of a forefinger obtained without ...
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      Mentions: Nankai University Xiaonong Zhu

    23. Revisiting optical clearing with dimethyl sulfoxide (DMSO)

      Explore www3.interscience.wiley.com Dermatology
      Functional optical characterization of disease progression and response to therapy suffers from loss of spatial resolution and imaging depth due to scattering. Here we report on the ability of dimethyl sulfoxide (DMSO) alone to reduce the optical scattering of skin. We observed a threefold reduction in the scattering of skin with topical DMSO application. With an in vivo window chamber model, we observed a threefold increase in light transmittance through the preparation and enhanced visualization of subsurface microvasculature. Collectively, our data demonstrate the potential of DMSO alone to mitigate effects of scattering, which we expect will improve molecular imaging studies ...
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      Mentions: Bernard Choi UC Irvine

    24. Multidisciplinary group aids laser-tissue research

      Explore Engineering News Dermatology
      Multidisciplinary group aids laser-tissue research
      One of the tools currently available within the BG is an optical coherence tomography (OCT) system, which is a laser imaging technology that can image different structures within tissue. OCT, coupled with other imaging techniques, has the potential to offer noninvasive biopsies and is a method of monitoring processes like wound healing over a period of time. It can also be used in tumour detection and the evaluation of a treatment. The technology offers similar result to histology in medicine, without the need to remove tissue as in the case of a biopsy or sacrificing the subject under investigation.
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      Mentions: Ann Singh
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