1. Articles in category: Dermatology

    265-288 of 503 « 1 2 ... 9 10 11 12 13 14 15 ... 19 20 21 »
    1. New tool helps non-melanoma patients avoid surgery (video)

      New tool helps non-melanoma patients avoid surgery (video)
      Over 13 million Americans have recurring history of non-melanoma skin cancer. They often have scarring from biopsies and surgery. But new technology is helping to change that. A recent biopsy found skin cancer in Patrice Mollica's lower lip. she thought she would need surgery to remove it. "So I knew what the procedure was gonna be and because of the location I knew there would be scarring, so that was my concern obviously, and also to remove it," Mollica said. She got a second opinion. Doctor Erin Gilbert used a new, FDA approved device, "an optical coherence tomography scanner ...
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    2. Evaluating the use of optical coherence tomography for the detection of epithelial cancers in vitro

      Evaluating the use of optical coherence tomography for the detection of epithelial cancers in vitro

      Optical coherence tomography (OCT) is a noninvasive imaging methodology that is able to image tissue to depths of over 1 mm. Many epithelial conditions, such as melanoma and oral cancers, require an invasive biopsy for diagnosis. A noninvasive, real-time, point of care method of imaging depth-resolved epithelial structure could greatly improve early diagnosis and long-term monitoring in patients. Here, we have used tissue-engineered (TE) models of normal skin and oral mucosa to generate models of melanoma and oral cancer. We have used these to determine the ability of OCT to image epithelial differences in vitro. We report that while in ...

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    3. Assessment of Tumor Thickness in Melanocytic Skin Lesions: Comparison of Optical Coherence Tomography, 20-MHz Ultrasound and Histopathology

      Assessment of Tumor Thickness in Melanocytic Skin Lesions: Comparison of Optical Coherence Tomography, 20-MHz Ultrasound and Histopathology
      Background: Accurate assessment of vertical tumor size is important for surgical treatment planning of melanocytic skin lesions. High-frequency ultrasound (HFUS) is frequently used for this purpose, but overestimation of tumor thickness is known as a problem especially in thin melanocytic lesions. Optical coherence tomography (OCT) as a new imaging technique might be a promising alternative. Objective: To evaluate the ability of OCT to accurately determine the vertical tumor thickness of melanocytic skin lesions and to compare it with HFUS and histopathology in order to improve surgical planning. Methods: In this single-center study, 26 melanocytic lesions were imaged by OCT and ...
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    4. Preoperative Characterization of Basal Cell Carcinoma Comparing Tumour Thickness Measurement by Optical Coherence Tomography, 20-MHz Ultrasound and Histopathology

      Preoperative Characterization of Basal Cell Carcinoma Comparing Tumour Thickness Measurement by Optical Coherence Tomography, 20-MHz Ultrasound and Histopathology
      Optical coherence tomography (OCT) is a new imaging method with promising results for several dermatological indications, including preoperative skin tumour characterization. While high-frequency ultrasound (HFUS) is frequently used for this purpose, overestimation of tumour thickness is a problem, due to subtumoral inflammatory infiltration that cannot be differentiated from tumour tissue. The aim of this single-centre study was to describe OCT features of basal cell carcinoma (BCC) and to determine vertical tumour thickness accurately, including a comparison with HFUS and histopathology. Tumour thickness values of 10 BCCs measured by OCT did not differ significantly from those measured by histopathology (median difference ...
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    5. AGFA Healthcare Releases SKINTELL an OCT Dermatology Product

      AGFA Healthcare Releases SKINTELL an OCT Dermatology Product
      AGFA Healtcare, a member of the AGFA-Gevaert Group and a business unit with a revenue of ~billion Euros, quietly released a dermatology OCT product around June of 2011. For virtually every researcher who has ever built an OCT imaging system the first thing they did was image their finger so the application is far from new and while the potential market for OCT in dermatology is quite large, the technical and business challenges are non-trivial. For example the skin does a good job at keeping light out and in many, but not all, places a skin biopsy is easy to ...
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    6. Feature Of The Week 10/9/11: Researchers at RWTH Aachen University Demonstrate Increased Tissue Contrast Using High-Resolution Simultaneous Dual-Band 3D OCT

      Feature Of The Week 10/9/11: Researchers at RWTH Aachen University Demonstrate Increased Tissue Contrast Using High-Resolution Simultaneous Dual-Band 3D OCT
      Classical Optical Coherence Tomography (OCT) systems represent morphological information by displaying the backscattered intensity of the OCT signal. Functional methods like spectroscopic OCT have been developed, extending the contrasting capabilities beyond morphological information. Spectroscopic information arises from wavelength dependent tissue features and has been retrieved by a time-frequency analysis of the OCT signal. However, this method requires high computational effort and is restricted to one wavelength band only.In contrast to a time frequency analysis, detecting in two distinct wavelength bands allows for covering large spectral bandwidths. Contrast enhancement is possible by encoding the spectral differences between both images into ...
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    7. Optical Coherence Tomography Used as a Modality to Delineate Basal Cell Carcinoma prior to Mohs Micrographic Surgery

      Optical Coherence Tomography Used as a Modality to Delineate Basal Cell Carcinoma prior to Mohs Micrographic Surgery
      Optical coherence tomography (OCT) has potential as a modality for in vivo imaging of non-melanoma skin cancer (NMSC). By allowing identification of sub-surface margins of NMSC lesions, the use of OCT could improve the rate of complete excision and reduce the average number of stages during Mohs micrographic surgery (MMS). The objective of this study was to use OCT to delineate the apparent sub-surface margins of NMSC lesions prior to their excision by MMS. Lesions were scanned with reference to a physical marker on the skin, and the apparent margins were then identified from the OCT images and marked on ...
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    8. Video on Michelson Diagnostics Vivosight Scanner In Use at a Dermatology Clinic as Seen on WABC News New York

      Video on Michelson Diagnostics Vivosight Scanner In Use at a Dermatology Clinic as Seen on WABC News New York
      The Michelson Diagnostics Vivosight scanner was recently featured on WABC News in New York. A copy of a text article can be seen Here. Dr. Erin Gilbert demonstrates the Vivosight scanner at her dermatology practice Gramercy Park Dermatology Associates which is offering the serviced in the United States. Dr. Gilbert says she charges patients $275 to use it. Part of that fee goes to the medical practice, part of it goes to the company to pay for the use of the machine.
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    9. New tool to help identify skin cancers

      New tool to help identify skin cancers
      NEW YORK (WABC) -- Summer is over, but now is when those new spots come up on the skin, leaving people worried and asking is it cancer? Now there's a new tool that's helping doctors answer that question right in their office. After having skin cancer three times Amanda Bosca wants to make sure the two new dots on her face are not cancer. Related Content More: Get Health E-News To help figure it out fast, her doctor is using a new device called the Vivosight Scanner. Using multi-beam laser technology, it creates an image on the monitor showing ...
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    10. Gordon McKenzie Discusses Michelson Diagnostics Dermatologic OCT Product (Video)

      Gordon McKenzie Discusses Michelson Diagnostics Dermatologic OCT Product (Video)
      Gordon McKenzie is the Director of Clinical Development at Michelson Diagnostics and oversees the clinical trials process showing the efficacy of high resolution Optical Coherence Tomography in disease management. Gordon talked to Science Capital about his work. For more information visit www.sciencecapital.co.uk.
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    11. Optical coherent tomography: promising in vivo measurement of hair shaft cross section

      Optical coherent tomography: promising in vivo measurement of hair shaft cross section

      Variations in hair shaft morphology reflect ethnical diversity, but may also indicate internal diseases, nutritional deficiency, or hair and scalp disorders. The measurement and the follow-up of the hair shaft thickness over a defined period of time would be a valuable diagnostic tool in clinical practice. Standard light microscopy (LM) measurements require the epilation of hair shafts and frequently yield inaccurate values caused by the elliptic geometry of human hair shafts. Optical coherence tomography (OCT) is a noninvasive investigation method based on the principles of Michelson interferometry with a detection depth of approximately 1 mm in human skin. Two-dimensional images ...

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    12. Using optical coherence tomography for the longitudinal non-invasive evaluation of epidermal thickness in a murine model of chronic skin inflammation

      Using optical coherence tomography for the longitudinal non-invasive evaluation of epidermal thickness in a murine model of chronic skin inflammation
      Background Non-invasive methods are desirable for longitudinal studies examining drug efficacy and disease resolution defined as decreases in epidermal thickness in mouse models of psoriasiform skin disease. This would eliminate the need for either sacrificing animals or collecting serial skin biopsies to evaluate changes in disease progression during an individual study. The quantitation of epidermal thickness using optical coherence tomography (OCT) provides an alternative to traditional histology techniques. Methods Using the KC-Tie2 doxycycline-repressible psoriasiform skin disease mouse model, OCT imaging was completed on diseased back skin of adult KC-Tie2 (n = 3–4) and control (n = 3–4) mice, followed immediately ...
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    13. Revolutionary Device For Use in Detecting Non-Melanoma Skin Cancer in Real Time, Alleviates Patient Stress, Can Reduce Invasive Biopsy

      Revolutionary Device For Use in Detecting Non-Melanoma Skin Cancer in Real Time, Alleviates Patient Stress, Can Reduce Invasive Biopsy
      Michelson Diagnostics Press Release.   A revolutionary new imaging device that can detect skin cancer like no other technology - - the VivoSightâ Optical Coherence Tomography (OCT) scanner - - is now available to dermatologists in the U.S. for the first time.  The VivoSightâ scan enables clinicians to see under the skin surface instantly, providing additional information which will allow them to better treat patients with non-melanoma skin cancer. Gramercy Park Dermatology in New York City is the first medical practice in the U.S.to offer the VivoSightâ scan to patients presenting with non-melanoma skin cancer.   According to leading researcher and dermatologist Dr ...
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    14. Optical properties of neonatal skin measured in vivo as a function of age and skin pigmentation

      Optical properties of neonatal skin measured in vivo as a function of age and skin pigmentation
      Knowledge of the optical properties of neonatal skin is invaluable when developing new, or improving existing optical techniques for use at the neonatal intensive care. In this article, we present in vivo measurements of the absorption μa and reduced scattering coefficient μs′ of neonatal skin between 450 and 600 nm and assess the influence of age and skin pigmentation on the optical properties. The optical properties were measured using a spatially resolved, steady state diffuse reflectance spectroscopy setup, combined with a modified spatially resolved diffusion model. The method was validated on phantoms with known values for the absorption and reduced ...
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    15. Non-invasive imaging techniques in the diagnosis of skin diseases

      Non-invasive imaging techniques in the diagnosis of skin diseases
      Introduction: In recent years, there has been an increasing interest in non-invasive imaging techniques in clinical and investigational dermatology. Besides the growing number of biophysical methods for the assessment of skin properties, novel imaging tools have emerged and classical imaging methods are substantially improved. Areas covered: This review focuses on well established and some of the most promising imaging techniques for application in dermatology and cutaneous research. These comprise dermoscopy, sonography, confocal microscopy, multiphoton tomography and optical coherence tomography. Non-invasive imaging techniques are presented concerning their functional principles, the history of their development and their current clinical and research application ...
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    16. Non-Invasive Tools for Improving Diagnosis of Non-Melanoma Skin Cancer: A Review

      Non-Invasive Tools for Improving Diagnosis of Non-Melanoma Skin Cancer: A Review
      Background Non-melanoma skin cancers (NMSC) are the most common cancers diagnosed in the western world[i]. The need for surgical treatment of such lesions is on the increase. The fact that the majority of such lesions appear on aesthetically sensitive areas of head and neck means that a non-invasive method of diagnosis has the potential to both eliminate the need for tissue biopsy, as well as act as an adjunct to surgery to ensure minimal healthy tissue is sacrificed. MethodsA review of all literature using databases of Pubmed and Medline was carried out. All the titles and abstracts of all ...
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      Mentions: OptiScan
    17. In vivo evaluation of human skin anisotropy by polarization-sensitive optical coherence tomography

      In vivo evaluation of human skin anisotropy by polarization-sensitive optical coherence tomography
      We performed an in vivo three-dimensional analysis of anisotropic changes in the dermal birefringence of mechanically deformed human skin using polarization-sensitive optical coherence tomography (PS-OCT). The papillary-dermal birefringence of the forehead increased significantly when the skin was shrunk parallel to the body axis, and decreased significantly when the skin was shrunk perpendicular to the body axis. En-face images of the papillary-dermal birefringence revealed variations among individual subjects, and that both shrinking parallel to and stretching in perpendicular to the body axis promoted the formation of macro rope-like birefringent domains. We found that PS-OCT is useful for understanding anisotropic properties of ...
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    18. Arthritis linked to skin condition

      Arthritis linked to skin condition
      RESEARCHERS in Yorkshire are harnessing powerful new imaging technology to investigate nail disease linked to a common skin condition which they believe could help predict if patients will go on to develop arthritis. Around one in 50 people suffer from the skin condition psoriasis and as many as half go on to develop nail problems. These can leave patients in significant pain, cause disfigurement in nails and loss of function in small joints. Doctors in Leeds were the first in the world to recognise in 1956 that some patients with psoriasis also go on to develop a specific type of ...
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      Mentions: Dennis McGonagle
    19. Effect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCT

      Effect of Localized Mechanical Indentation on Skin Water Content Evaluated Using OCT
      The highly disordered refractive index distribution in skin causes multiple scattering of incident light and limits optical imaging and therapeutic depth. We hypothesize that localized mechanical compression reduces scattering by expulsing unbound water from the dermal collagen matrix, increasing protein concentration and decreasing the number of index mismatch interfaces between tissue constituents. A swept-source optical coherence tomography (OCT) system was used to assess changes in thickness and group refractive index in ex vivo porcine skin, as well as changes in signal intensity profile when imaging in vivo human skin. Compression of ex vivo porcine skin resulted in an effective strain ...
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    20. Leading Imaging Research Group uses VivoSight OCT Scanner to Assess Nail Disease in Psoriasis

      Leading Imaging Research Group uses VivoSight OCT Scanner to Assess Nail Disease in Psoriasis
      Michelson Diagnostics Press Release - Recent studies by the Musculoskeletal Biomedical Research Unit at Leeds University NHS Trust, UK, indicate that Optical Coherence Tomography has considerable potential for the evaluation of psoriatic nail disease. Nail disease, which occurs in 10-55% of patients with Psoriasis and in 53-86% of patients with Psoriatic Arthritis, is increasingly recognised to be of major clinical and research relevance. As yet there are no objective methods to diagnose and assess nail disease in these patients An initial case study, published in Dermatology, compared nail bed images produced by the Michelson Diagnostics VivoSight OCT scanner with those produced ...
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    21. Optical Coherence Tomography: A New Tool to Assess Nail Disease in Psoriasis?

      Optical Coherence Tomography: A New Tool to Assess Nail Disease in Psoriasis?

      Nail disease is a characteristic manifestation of the psoriatic disease spectrum but is poorly understood. Objective: Given the intrinsically high spatial resolution imaging capabilities of optical coherence tomography (OCT), we assessed its value in psoriatic nail disease compared to high-resolution ultrasonography (US). Methods: All fingernails in a psoriatic arthritis patient with nail changes were scanned with OCT, and findings were compared with high-resolution US. Results: US showed loss of trilaminar appearance in all nails, resulting in the nail plate being visualized as a single hyperechoic layer with inhomogeneous thickness. The OCT images showed much higher-resolution changes with prominent thickening in ...

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    22. Comparison of ex vivo optical coherence tomography with conventional frozen-section histology for visualizing basal cell carcinoma during Mohs micrographic surgery

      Comparison of ex vivo optical coherence tomography with conventional frozen-section histology for visualizing basal cell carcinoma during Mohs micrographic surgery
      Background  Mohs micrographic surgery offers high cure rates of nonmelanoma skin cancers with optimal sparing of normal tissue. However, it is generally more time-consuming and labour-intensive than traditional surgery. Optical coherence tomography (OCT) is an emergent technology that has the potential to diagnose basal cell carcinoma (BCC) in vivo.Objective  To compare the efficiency and accuracy of ex vivo OCT with frozen-section histology for identifying BCC in Mohs surgery.Methods  Thirty-eight patients were enrolled. After the stages were taken, images were captured with an OCT microscope and subsequently processed for standard frozen sections.Results  In total, 75 sections were scanned ...
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    23. Michelson Diagnostics Announces US Expansion

      Michelson Diagnostics Announces US Expansion
      Michelson Diagnostics Press Release - Orpington, Kent (UK) & Boston, MA (US): Michelson Diagnostics, the leading skin cancer imaging firm, today announced plans to expand availability of their revolutionary products for skin cancer imaging in the United States. Michelson Diagnostics has recruited Karen Miller Gillis as VP Sales & Marketing / General Manager of its new US subsidiary Michelson Diagnostics Inc. The new company is based in Massachusetts.  Karen brings 16 years’ sales and marketing experience in the medtech industry to Michelson. She has a track record of generating dramatic revenue growth, launching new products, year-after-year profitability, and capturing a significant portion of market ...
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    24. Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3D morphological skin imaging

      Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3D morphological skin imaging

      A noninvasive, multimodal photoacoustic and optical coherence tomography (PAT/OCT) scanner for three-dimensional in vivo (3D) skin imaging is described. The system employs an integrated, all optical detection scheme for both modalities in backward mode utilizing a shared 2D optical scanner with a field-of-view of ~13 × 13 mm2. The photoacoustic waves were detected using a Fabry Perot polymer film ultrasound sensor placed on the surface of the skin. The sensor is transparent in the spectral range 590-1200 nm. This permits the photoacoustic excitation beam (670-680 nm) and the OCT probe beam (1050 nm) to be transmitted through the sensor head ...

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