1. Articles in category: Dermatology

    265-288 of 430 « 1 2 ... 9 10 11 12 13 14 15 ... 16 17 18 »
    1. Comparison of pulsed photothermal radiometry, optical coherence tomography and ultrasound for melanoma thickness measurement in PDMS tissue phantoms

      Comparison of pulsed photothermal radiometry, optical coherence tomography and ultrasound for melanoma thickness measurement in PDMS tissue phantoms

      Melanoma accounts for 75% of all skin cancer deaths. Pulsed photothermal radiometry (PPTR), optical coherence tomography (OCT) and ultrasound (US) are non-invasive imaging techniques that may be used to measure melanoma thickness, thus, determining surgical margins. We constructed a series of PDMS tissue phantoms simulating melanomas of different thicknesses. PPTR, OCT and US measurements were recorded from PDMS tissue phantoms and results were compared in terms of axial imaging range, axial resolution and imaging time. A Monte Carlo simulation and three-dimensional heat transfer model was constructed to simulate PPTR measurement. Experimental results show that PPTR and US can provide a ...

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    2. ISIS Optronics GmbH Out of Business

      ISIS Optronics GmbH Out of Business
      As of October 13, 2010, ISIS Optronics GmbH went out of business as per its bankruptcy proceedings. ISIS optronics GmbH specialises in microscopic diagnosis and inspection of tissues used in medical and industrial applications. The company's products include SkinDex 300, which diagnoses skin microscopically down to 1 mm penetration and StraDex 80, which offers layer thickness evaluation and micro-flaw inspection in industrial materials. ISIS was founded in 1999 and is based in Mannheim, Germany.
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      Mentions: ISIS Optronics
    3. Quantitative optical coherence tomography of skin lesions induced by different ultraviolet B sources

      Quantitative optical coherence tomography of skin lesions induced by different ultraviolet B sources

      Ultraviolet B (UVB) has been widely used in dermatological phototherapy. Narrowband UVB (NB-UVB), with a peak at 311 nm, is considered to be more effective than broadband UVB (BB-UVB). However, the safety of NB-UVB is controversial. In this study, we first introduced optical coherence tomography (OCT), a novel, non-invasive in vivo imaging technology, to assess the effect of NB-UVB and BB-UVB on skin. Balb/c mice dorsal skin was exposed with increasing UVB doses (1MED, 3MEDs and 5MEDs), and then OCT images of the tissues were obtained by an OCT system with 1310 nm central wavelength. Quantitative parameters (skin thickness ...

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    4. New collaboration targets skin cancer with hybrid imaging probe

      New collaboration targets skin cancer with hybrid imaging probe

      A new collaboration between researchers at King’s Health Partners Academic Health Sciences Centre and an innovative British company is targeting skin cancer with a new type of imaging probe. The £98,500 research project has received 75% funding through a National Institute for Health Research (NIHR) Invention for Innovation ‘i4i’ grant awarded to the partners, Guy’s and St Thomas’ NHS Foundation Trust, King’s College London and Michelson Diagnostics Ltd.   The aim of the project is to develop and test a hybrid imaging probe that combines the advantages of Michelson Diagnostics’ novel Multi-Beam OCT (Optical Coherence Tomography) probe ...

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    5. Speckle texture analysis of optical coherence tomography images

      Speckle texture analysis of optical coherence tomography images

      Optical coherence tomography (OCT) is an imaging technique based on the low coherence interferometry, in which signals are obtained based on the coherent addition of the back reflected light from the sample. Applying computational methods and automated algorithms towards the classification of OCT images allows a further step towards enhancing the clinical applications of OCT. One attempt towards classification could be achieved by statistically analyzing the texture of the noisy granular patterns - speckles that make the OCT images. An attempt has been made to quantify the scattering effects based on the speckle texture patterns the scatterers produce. Statistical inference is ...

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    6. Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution

      Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution
      In this study, we used optical coherence tomography (OCT) to extensively investigate, for the first time, the effect that microneedle (MN) geometry (MN height, and MN interspacing) and force of application have upon penetration characteristics of soluble poly(methyl vinyl ether-co-maleic anhydride, PMVE/MA) MN arrays into neonatal porcine skin in vitro. The results from OCT investigations were then used to design optimal and suboptimal MN-based drug delivery systems and evaluate their drug delivery profiles cross full thickness and dermatomed neonatal porcine skin in vitro. It was found that increasing the force used for MN application resulted in a significant ...
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    7. Glucose Monitor And Method Of Use Thereof (Wo 2010/094008)

      Glucose Monitor And Method Of Use Thereof (Wo 2010/094008)
      An apparatus for monitoring glucose comprising a processor, an indicating mechanism and sensors that are disposed proximate the skin of a person when the skin is in contact with a motor vehicle operational component such as the steering wheel. The apparatus for monitoring glucose measures the driver's glucose concentration via optical coherence tomography or other non-invasive technique, analyzes the driver's glucose concentration via the processor and displays the driver's glucose concentration via the indicator, or alternately sends an alarm signal. The method for monitoring glucose further comprises programming the processor with a range of glucose concentrations, comparing ...
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    8. Optical Biopsy at the Bedside

      Optical Biopsy at the Bedside
      Skin biopsy is essential for the diagnosis of many cutaneous conditions. Beyond the cost and technical considerations, it is an invasive, painful, and scarring procedure. These factors lead dermatologists to be selective about what and when we biopsy, resulting in potential delay and misdiagnosis. Biopsy also is subject to sampling error; because it changes the tissue permanently, it is not amenable to longitudinal evaluation. Because specimen processing creates a delay, some treatment options are limited. Hence, there is a need to develop new noninvasive methods to permit immediate microscopic visualization of tissues in vivo or ex vivo. One might consider ...
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    9. Quantum Dot Superluminescent Diodes for Optical Coherence Tomography: Skin Imaging

      Quantum Dot Superluminescent Diodes for Optical Coherence Tomography: Skin Imaging

      We present a high-power (18 mW continuous wave exiting a single-mode fiber and 35 mW exiting the facet), broadband (85 nm full-width at half-maximum) quantum dot-based superluminescent diode, and apply it to a time-domain optical coherence tomography (OCT) setup. First, we test its performance with increasing optical feedback. Then we demonstrate its imaging properties on tissue-engineered (TE) skin and in vivo skin. OCT allows the tracking of epidermal development in TE skin, while the higher power source allows better sensitivity and depth penetration for imaging of in vivo skin layers.

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    10. In-vivo dynamic characterization of microneedle skin penetration using optical coherence tomography

      In-vivo dynamic characterization of microneedle skin penetration using optical coherence tomography
      The use of microneedles as a method of circumventing the barrier properties of the stratum corneum is receiving much attention. Although skin disruption technologies and subsequent transdermal diffusion rates are being extensively studied, no accurate data on depth and closure kinetics of microneedle-induced skin pores are available, primarily due to the cumbersome techniques currently required for skin analysis. We report on the first use of optical coherence tomography technology to image microneedle penetration in real time and in vivo. We show that optical coherence tomography (OCT) can be used to painlessly measure stratum corneum and epidermis thickness, as well as ...
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    11. In vivo quantification of propylene glycol, glucose and glycerol diffusion in human skin with optical coherence tomography

      In vivo quantification of propylene glycol, glucose and glycerol diffusion in human skin with optical coherence tomography

      The purpose of study is to quantify and compare diffusion of propylene glycol, glucose, glycerol in the human skin in vivo noninvasively. Optical coherence tomography (OCT) was utilized in the functional imaging of optical cleaning agents for monitoring and quantifying the permeability coefficients (PCs) of them. Our experiments showed that the permeability coefficient of 40% propylene glycol from different subjects was averaged and found to be (2.52 ± 0.02) × 10−6 cm/s, the permeability coefficient of 40% glucose was (1.94 ± 0.05) × 10−6 cm/s, and the permeability coefficient of 40% glycerol was (1.82 ± 0 ...

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    12. In vivo measurement of the human epidermal thickness in different localizations by multiphoton laser tomography

      In vivo measurement of the human epidermal thickness in different localizations by multiphoton laser tomography
      Background: The in vivo measurement of epidermal thickness is still challenging. While ultrasound, optical coherence tomography and confocal laser microscopy are used with moderate success, this issue has not been addressed by multiphoton laser tomography. Objectives: In the present study, an in vivo measurement of four different morphometric epidermal parameters is performed. Methods: Thirty healthy volunteers aged 21–82 years were included in the study after informed consent and approval of the local ethics committee. At the dorsal forearm and the dorsum of the hand, the thicknesses of the total epidermis, viable epidermis and stratum corneum and the depth of ...
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    13. The Evolution of Melanoma Diagnosis: 25 Years Beyond the ABCDs

      The Evolution of Melanoma Diagnosis: 25 Years Beyond the ABCDs
      Early detection of malignant melanoma remains the key factor in lowering mortality from this cancer. Recognizing the importance of this issue 25 years ago, our group at New York University published in CA: A Cancer Journal for Clinicians the mnemonic "ABCD" to facilitate the early diagnosis of melanoma. Studies have demonstrated the usefulness of this paradigm in enhancing early melanoma diagnosis as a part of clinical examinations, mass screenings, and public education programs. Approaches to melanoma diagnosis have dynamically evolved during the ensuing quarter century. In the 1990s, dermoscopy enabled the recognition of new subsurface features to differentiate between malignant ...
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    14. Using swept-source optical coherence tomography to monitor the formation of neo-epidermis in tissue-engineered skin

      Using swept-source optical coherence tomography to monitor the formation of neo-epidermis in tissue-engineered skin

      There is an increasing need for a robust, simple to use, non-invasive imaging technology to follow tissue-engineered constructs as they develop. Our aim was to evaluate the use of swept-source optical coherence tomography (SS-OCT) to image tissue-engineered skin as it developed over several weeks. Tissue-engineered skin was produced using both de-epithelialized acellular dermis (DED) and amorphous collagen gels. In both cases the epidermis could be readily distinguished from the neodermis, based on a comparison with standard destructive histology of samples. Constructs produced with DED showed more epidermal/dermal maturation than those produced using collagen. The development of tissue-engineered skin based ...

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    15. Bioengineering and subjective approaches to the clinical evaluation of dry skin

      Bioengineering and subjective approaches to the clinical evaluation of dry skin
      Dry skin (also known as xerosis) is a cutaneous reaction pattern indicative of abnormal desquamation, which has not only cosmetic considerations, but can also lead to the penetration of irritants and allergens through the stratum corneum (SC). Over the last few decades, our understanding of the structure, composition, formation and function of the SC has advanced tremendously; however, despite these advancements, the occurrence of dry skin remains prevalent in the adult population. The clinical evaluation of dry skin is therefore of significant importance to the cosmetic industry not only for understanding the condition but also for measuring the effects of ...
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    16. Feature Of The Week 6/20/10: Fourier Domain Pump-Probe Optical Coherence Tomography Imaging

      Feature Of The Week 6/20/10: Fourier Domain Pump-Probe Optical Coherence Tomography Imaging

      Feature Of The Week 6/20/10: Researchers from the Laboratory for Optical and Molecular Imaging at Texas A&M; University have recently published on a fusing Optical Coherence Tomography (OCT) imaging with pump-probe spectroscopy. Shown here is a summary of some of their recent work. Contrast in Optical Coherence Tomography (OCT) is primarily derived from local variations in the scattering coefficient, which does not vary widely among different molecular species. As a consequence, the ability to resolve specific molecular species with OCT is very limited. However, the extraction of molecular information is highly desirable because it could provide valuable ...

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    17. Imaging port wine stains by fiber optical coherence tomography

      Imaging port wine stains by fiber optical coherence tomography

      We develop a fiber optical coherence tomography (OCT) system in the clinical utility of imaging port wine stains (PWS). We use our OCT system on 41 patients with PWS to document the difference between PWS skin and contralateral normal skin. The system, which operates at 4 frames/s with axial and transverse resolutions of 10 and 9 µm, respectively, in the skin tissue, can clearly distinguish the dilated dermal blood vessels from normal tissue. We present OCT images of patients with PWS and normal human skin. We obtain the structural parameters, including epidermal thickness and diameter and depth of dilated ...

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    18. In vitro study of ultrasound and different-concentration glycerolinduced changes in human skin optical attenuation assessed with optical coherence tomography

      In vitro study of ultrasound and different-concentration glycerolinduced changes in human skin optical attenuation assessed with optical coherence tomography

      Previous studies have demonstrated the ultrasound-induced skin optical clearing enhancement with topical application of 60% glycerol (G) on in vitro porcine skin and in vivo human skin. Our purpose was to find the relation between the effect of optical skin clearing and different concentrations of glycerol and to find more effective ultrasound-glycerol combinations on optical skin clearing. The enhancement effect of ultrasound [Sonophoresis (SP) delivery] in combination with 40% G, 60% G, and 80% G on in vitro human skin optical clearing was investigated. Light imaging depths of skin were measured using optical coherence tomography. Different concentrations of glycerol and ...

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    19. Assessment of a liquid lens enabled in vivo optical coherence microscope

      Assessment of a liquid lens enabled in vivo optical coherence microscope
      The optical aberrations induced by imaging through skin can be predicted using formulas for Seidel aberrations of a plane-parallel plate. Knowledge of these aberrations helps to guide the choice of numerical aperture (NA) of the optics we can use in an implementation of Gabor domain optical coherence microscopy (GD-OCM), where the focus is the only aberration adjustment made through depth. On this basis, a custom-designed, liquid-lens enabled dynamic focusing optical coherence microscope operating at 0.2 NA is analyzed and validated experimentally. As part of the analysis, we show that the full width at half-maximum metric, as a characteristic descriptor ...
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    20. In Vivo, In Situ Imaging of Microneedle Insertion into the Skin of Human Volunteers Using Optical Coherence Tomography

      In Vivo, In Situ Imaging of Microneedle Insertion into the Skin of Human Volunteers Using Optical Coherence Tomography

      Purpose  To gather sub-surface in situ images of microneedle-treated human skin, in vivo, using optical coherence tomography (OCT). This is the first study to utilise OCT to investigate the architectural changes that are induced in skin following microneedle application. Methods  Steel, silicon and polymer microneedle devices, with different microneedle arrangements and morphologies, were applied to two anatomical sites in human volunteers following appropriate ethical approval. A state-of-the-art ultrahigh resolution OCT imaging system operating at 800 nm wavelength and <3 µm effective axial resolution was used to visualise the microneedle-treated area during insertion and/or following removal of the device, without ...

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    21. Multispectral in vivo three-dimensional optical coherence tomography of human skin

      Multispectral in vivo three-dimensional optical coherence tomography of human skin

      The capability of optical coherence tomography (OCT) to perform “optical biopsy” of tissues within a depth range of 1 to 2 mm with micron-scale resolution in real time makes it a promising biomedical imaging modality for dermatologic applications. Three high-speed, spectrometer-based frequency-domain OCT systems operating at 800 nm (20,000 A-scans/s), 1060 nm, and 1300 nm (both 47,000 A-scans/s) at comparable signal-to-noise ratio (SNR), SNR roll-off with scanning depth, and transverse resolution (<15 μm) were used to acquire 3-D tomograms of glabrous and hairy human skin in vivo. Images obtained using these three systems were compared in ...

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    22. Michelson Diagnostic’s Multi Beam OCT technology to Provide Significant Cost Savings for Treating Non-Melanoma Skin Cancer

      Michelson Diagnostic’s Multi Beam OCT technology to Provide Significant Cost Savings for Treating Non-Melanoma Skin Cancer
      (Orpington, UK) April 29, 2010 – At a time where non-melanoma skin cancer is reaching epidemic proportions in the U.S, accounting for 4.5% of all Medicare cancer costs; there is a new breakthrough in skin imaging that is predicted to provide significant cost savings. Michelson Diagnostics, a leading innovator in Multi-Beam Optical Coherence Tomography (OCT) products, has developed the VivoSight scanner, which has shown great potential in pre-operation delineation of tumor margins in skin cancer patients. The scanner, which received 510 FDA Clearance in January, is able to provide extraordinarily high resolution images of tumors in real-time, to improve ...
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    23. Optical coherence tomography

      Optical coherence tomography

      (Article in German) Optical coherence tomography (OCT) is a high-resolution imaging method for in vivo investigation of the human skin. In cross-sectional images of several millimeters length with a penetration depth of the light signal into deeper parts of the dermis, architectural details of the upper skin layers can be assessed and monitored non-invasively over time. The resolution is not high enough to visualize cellular details. Several studies have been performed using OCT to assess its significance as a diagnostic tool for dermatology. The actual technical configuration of OCT is suitable to assess therapeutic effects objectively and to observe skin ...

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    24. Non-invasive assessment of healing of bacteria infected and uninfected wounds using optical coherence tomography

      Non-invasive assessment of healing of bacteria infected and uninfected wounds using optical coherence tomography
      Bacterial infection is one of the main predisposing factors for the delay in wound healing. To facilitate a timely decision for correct therapy, it is important to accurately monitor the morphological changes in the infected wounds using noninvasive tools. In the present study, we have explored the use of optical coherence tomography (OCT) for monitoring the healing of superficial wounds infected with Staphylococcus aureus in mice under in vitro and in vivo conditions and studied the changes in collagen birefringence in the infected wounds. The tape stripping method was used for generating superficial skin wounds in mice and wounds were ...
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