1. Articles in category: Dermatology

    265-288 of 680 « 1 2 ... 9 10 11 12 13 14 15 ... 27 28 29 »
    1. Michelson Diagnostics to launch enhanced software for VivoSight OCT scanner

      Michelson Diagnostics to launch enhanced software for  VivoSight OCT scanner

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces the launch of its upgraded VivoSight OCT scanner with a new software technology that provides additional features for dermatologists to investigate skin lesions such as non-melanoma skin cancer. The VivoSight OCT scanner enables the dermatologist to see vertical cross-sectional images of sub-surface skin tissue to depths of 1-1.5 mm in high definition, providing the clinician with important information about the type, depth and lateral spread of the skin lesion that is not possible to determine from its surface visual appearance. Our ...

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    2. In vivo enhancement of imaging depth for optical coherence tomography by eudermic agents on ridgedand meshed human skin

      In vivo enhancement of imaging depth for optical coherence tomography by eudermic agents on ridgedand meshed human skin

      Non-invasive skin analysis by optical coherence tomography (OCT) is limited because of the absorption and scattering properties of the tissue. There are several possibilities for enhancing OCT images. The purpose of this study was to demonstrate that image quality can be improved using the hyperosmolar agents glucose and glycerol while investigating human ridged and meshed skin areas, without causing damage to the tissue. The experiments were carried out on the palm and the forearm of ten volunteers. After application of the substances in the test area, the penetration depth and image contrast were measured at intervals of 5 min for ...

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    3. Michelson Diagnostics targets malignant melanoma using OCT imaging with €2.3M EU funding

      Michelson Diagnostics targets malignant melanoma using OCT imaging with €2.3M EU funding

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, announces that the European Union has awarded a €2.26 million Framework 7 grant to a consortium of seven partners, towards the cost of a project targeting malignant melanoma with OCT imaging. Using Michelson Diagnostics’ OCT imaging system, VivoSight, the project, named 'ADVANCE' (Automatic Detection of VAscular Networks for Cancer Evaluation), aims to demonstrate that multi-beam OCT imaging can be used to assess the aggressiveness of melanomas quickly and efficiently. Michelson Diagnostics is the lead partner in the ADVANCE project. Melanoma is the most ...

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    4. Nano-sensitive optical coherence tomography

      Nano-sensitive optical coherence tomography

      Depth resolved label-free detection of structural changes with nanoscale sensitivity is an outstanding problem in the biological and physical sciences and has significant applications in both the fundamental research and healthcare diagnostics arenas. Here we experimentally demonstrate a novel label-free depth resolved sensing technique based on optical coherence tomography (OCT) to detect structural changes at the nanoscale. Structural components of the 3D object, spectrally encoded in the remitted light, are transformed from the Fourier domain into each voxel of the 3D OCT image without compromising sensitivity. Spatial distribution of the nanoscale structural changes in the depth direction is visualized in ...

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    5. In vivo, high-resolution, three-dimensional imaging of port wine stain microvasculature in human skin

      In vivo, high-resolution, three-dimensional imaging of port wine stain microvasculature in human skin

      Port-wine stain (PWS) is a congenital, progressive vascular malformation of the dermis. In the past few years, advances in optical coherence tomography (OCT) technology have greatly increased imaging speed. Sophisticated numerical algorithms have improved the sensitivity of Doppler OCT dramatically. These improvements have enabled the noninvasive, high-resolution, three-dimensional functional imaging of PWS skin. In this study, high-resolution, three-dimensional, microvasculature imaging of PWS using Doppler OCT technique is demonstrated. Three-dimensional imaging of the subsurface vessel network of the dermis can provide information for accurate PWS classification and guidance for effective laser treatment. Invasive methods such as histology following biopsy and confocal ...

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    6. MedLumics Expands Management Team in Preparation for 2014 Launch of First Generation Diagnostic Imaging System for Dermatology

      MedLumics Expands Management Team in Preparation for 2014 Launch of First Generation Diagnostic Imaging System for Dermatology

      MedLumics, a medical imaging company specializing in advanced optical coherence tomography (OCT) technology , has announced the appointment of Miguel Eslava to the new position of vice president and chief operating officer. With more than a decade of senior management experience at GE Healthcare, Mr. Eslava brings significant business operations expertise to the company in advance of the anticipated launch of the first point-of-care diagnostic imaging system for dermatology in the second half of 2014. “We expect Miguel to play a critical role at MedLumics as we move from a research and development stage company to a commercial organization” “We expect ...

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    7. Imaging of Mohs Micrographic Surgery Sections Using Full-Field Optical Coherence Tomography: A Pilot Study

      Imaging of Mohs Micrographic Surgery Sections Using Full-Field Optical Coherence Tomography: A Pilot Study

      Background Full-field optical coherence tomography (FF-OCT) is a new noninvasive imaging technique that can see down to the cellular level without tissue preparation or contrast agents. Objective To use FF-OCT to image Mohs micrographic surgery specimens and verify the ability of a dermatopathologist to identify or exclude malignancy. Materials and Methods Two Mohs surgeons supplied 18 Mohs sections from 11 patients. Each section was scanned using the FF-OCT, and a dermatopathologist blinded to the diagnosis examined the images for malignancy. The FF-OCT images were then compared with the intraoperative hematoxylin and eosin (H&E)-stained frozen sections for concordance. Results ...

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    8. Michelson Diagnostics Announces £1.98 Million Financing

      Michelson Diagnostics Announces £1.98 Million Financing

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography ('OCT') technology, is delighted to announce the first closing of its Series A2 Financing. The round, which was oversubscribed, raised £1.98 million ( $3.25million ) from existing investors, led by Octopus Investments and supported by Catapult Venture Managers Ltd and London Business Angels, and several business angels. The funds will be used for several purposes including expanding VivoSight TM sales in Germany , where the system was launched in mid-2011 and where it is reimbursed for use in the diagnosis of non-melanoma skin cancer (NMSC), the commonest ...

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    9. Histopathological correlates of basal cell carcinoma in slice and en-face imaging modes of high-definition optical coherence tomography

      Histopathological correlates of basal cell carcinoma in slice and en-face imaging modes of high-definition optical coherence tomography

      Background High-definition optical coherence tomography (HD-OCT) scanners have recently been developed providing significantly higher resolution than conventional OCT . Objectives To assess the relationship between recently defined histopathological HD-OCT correlates of basal cell carcinomas (BCC) and possible predictors for the most common tumour subtypes. Methods For HD-OCT imaging, we used the Skintell ® device (Agfa Healthcare, Mortsel, Belgium). Twenty-five BCCs were histopathologically (including vertical as well horizontal haematoxylin and eosin and Alcian blue sectioning) confirmed and correlated with HD-OCT images. Results In the en-face mode, lobulated nodules were seen in 21 of the 25 lesions (84%), peripheral rimming in 18 (25/72 ...

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    10. Optical coherence tomography: a reliable alternative to invasive histological assessment of acute wound healing in human skin?

      Optical coherence tomography: a reliable alternative to invasive histological assessment of acute wound healing in human skin?

      Background Gold standard assessment of acute wound healing has traditionally been through histological analysis of biopsied tissue. However, this process is invasive with recognised side-effects. Optical coherence tomography (OCT) is a non-invasive technique generating high resolution real-time images of cutaneous architecture. Objective To compare OCT with histological assessment of in-vivo acute wound healing and ascertain level of agreement between modalities for measurement of defined cutaneous structures. Methods 5mm punch biopsies were harvested from 50 healthy volunteers. Wounds healed by secondary intention until they were re-excised 7, 14, 21 or 28 days later depending on random group allocation. Wounds were assessed ...

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    11. Non Invasive Diagnostic Techniques in Clinical Dermatology (Textbook)

      Non Invasive Diagnostic Techniques in Clinical Dermatology (Textbook)

      Optical coherence tomography (OCT) is a noninvasive imaging method. Using infrared broadband light sources, images of superficial skin layers can be obtained in vivo and real time. In dermatology, OCT can be used for investigation of skin tumors and inflammatory skin diseases, for quantification of skin changes, and for evaluation of treatment effects

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    12. Skin Evaluation Method And Skin Evaluation Device

      Skin Evaluation Method And Skin Evaluation Device

      A profile is created on the basis of an interference signal obtained by optical coherence tomography, the profile having optical reflectance in relation to depth in a depth range that extends from the epidermis to the dermal upper layer. The difference between a reflectance (R1) at a minimum point (P1) and a reflectance (R2) at a maximum point (P2) is calculated from the created profile to obtain an evaluation index. The state of skin is evaluated on the basis of the evaluation index.

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    13. Optical Coherence Tomography Imaging of Non-melanoma Skin Cancer Undergoing Photodynamic Therapy Reveals Subclinical Residual Lesions

      Optical Coherence Tomography Imaging of Non-melanoma Skin Cancer Undergoing Photodynamic Therapy Reveals Subclinical Residual Lesions

      Background Photodynamic therapy with methyl aminolaevulinate (MAL-PDT) is a widely used non-invasive treatment modality for non-melanoma skin cancer (NMSC). The outcome of MAL-PDT is usually primarily evaluated clinically. Optical coherence tomography (OCT) is a non-invasive imaging technology based on interferiometry. OCT has been proven to provide high accuracy in identifying NMSC lesions and performing thickness measurements of thin tumours. Objectives To describe the OCT morphology in in-vivo NMSC lesions during MAL-PDT treatment and to investigate the use of OCT in evaluating the response of MAL-PDT treated NMSC lesions Methods A total of 18 biopsy-proven basal cell carcinomas and actinic keratoses ...

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    14. Uses of non-invasive imaging in the diagnosis of skin cancer: an overview of the currently available modalities

      Uses of non-invasive imaging in the diagnosis of skin cancer: an overview of the currently available modalities

      Background Emerging tools for the diagnosis of skin cancer are non-invasive imaging devices that allow for skin visualization without biopsy. While the capabilities of non-invasive imaging tools are far-reaching, each varies in its resolution depth, image clarity, clinical applicability, accuracy, sensitivity, and specificity. Objective The objective of this review is to evaluate non-invasive imaging modalities, and examine their capabilities, conditions for use, clinical applications, and limitations. Materials and methods A literature review was conducted on Pubmed using the search term “non-invasive diagnostic imaging tools and skin”. Relevant citations suggested by Pubmed were included. Each non-invasive imaging tool evaluated was also ...

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    15. CAPTURING THE VITAL VASCULAR FINGERPRINT WITH OPTICAL COHERENCE TOMOGRAPHY

      CAPTURING THE VITAL VASCULAR FINGERPRINT WITH OPTICAL COHERENCE TOMOGRAPHY

      Using fingerprints as a method to identify an individual has been accepted in forensics since the 19 th century, and the fingerprint has become one of the most widely used biometric characteristics. Most of the modern fingerprint recognition systems are based on the print pattern of the finger surface and are not robust against spoof attaching. There may be problems where there are scars or cuts on fingertips. Optical coherence tomography (OCT) is a noncontact imaging technique which can capture high resolution, 3D images from within highly scattering biological tissues. There has been great interest to use OCT for fingerprint ...

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    16. Feature Of The Week 11/17/13: Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

      Feature Of The Week 11/17/13: Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

      Fractional photothermolysis induced by non-ablative fractional lasers (NAFLs) or ablative fractional lasers (AFLs) can remodel the skin, regenerate collagen, and remove tumor tissue. However, fractional laser treatments may result in severe side effects, and multiple treatments are required to achieve the expected outcome. Thus, the treatment outcome and downtime after fractional laser treatments are key issues to determine the following treatment strategy. In this study, an optical coherence tomography (OCT) system was implemented for in vivo studies of wound healing after NAFL and AFL treatments. According to the OCT scanning results, the laser-induced photothermolysis including volatilization and coagulation could be ...

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    17. Assessment of human burn scars with optical coherence tomography by imaging the attenuation coefficient of tissue after vascular masking

      Assessment of human burn scars with optical coherence tomography by imaging the attenuation coefficient of tissue after vascular masking

      The formation of burn-scar tissue in human skin profoundly alters, among other things, the structure of the dermis. We present a method to characterize dermal scar tissue by the measurement of the near-infrared attenuation coefficient using optical coherence tomography (OCT). To generate accurate en face parametric images of attenuation, we found it critical to first identify (using speckle decorrelation) and mask the tissue vasculature from the three-dimensional OCT data. The resulting attenuation coefficients in the vasculature-masked regions of the dermis of human burn-scar patients are lower in hypertrophic ( 3.8 ± 0.4     mm − 1 ) and normotrophic ( 4.2 ± 0.9 ...

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    18. In vivo, high-resolution, three-dimensional imaging of port wine stain microvasculature in human skin

      In vivo, high-resolution, three-dimensional imaging of port wine stain microvasculature in human skin

      Background and Objectives Port-wine stain (PWS) is a congenital, progressive vascular malformation of the dermis. The use of optical coherence tomography (OCT) for the characterization of blood vessels in PWS skin has been demonstrated by several groups. In the past few years, advances in OCT technology have greatly increased imaging speed. Sophisticated numerical algorithms have improved the sensitivity of Doppler OCT dramatically. These improvements have enabled the noninvasive, high-resolution, three-dimensional functional imaging of PWS skin. Here, we demonstrate high-resolution, three-dimensional, microvasculature imaging of PWS and normal skin using Doppler OCT technique. Study Design/Materials and Methods The OCT system uses ...

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    19. Long-term time-lapse multimodal intravital imaging of regeneration and bone-marrow-derived cell dynamics in skin (World Scientific)

      Long-term time-lapse multimodal intravital imaging of regeneration and bone-marrow-derived cell dynamics in skin (World Scientific)

      A major challenge for translating cell-based therapies is understanding the dynamics of cells and cell populations in complex in vivo environments. Intravital microscopy has shown great promise for directly visualizing cell behavior in vivo. However, current methods are limited to relatively short imaging times (hours), by ways to track cell and cell population dynamics over extended time-lapse periods (days to weeks to months), and by relatively few imaging contrast mechanisms that persist over extended investigations. We present technology to visualize and quantify complex, multifaceted dynamic changes in natural deformable skin over long time periods using novel multimodal imaging and a ...

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    20. Optical Coherence Tomography Imaging of Erythroplasia of Queyrat and Treatment with Imiquimod 5% Cream: A Case Report

      Optical Coherence Tomography Imaging of Erythroplasia of Queyrat and Treatment with Imiquimod 5% Cream: A Case Report

      Lesion biopsy is currently used to diagnose erythroplasia of Queyrat (EQ), a rare squamous cell carcinoma in situ of the glans penis, or to determine whether the cancer is invasive, although the results only apply to the area from which the biopsy is taken. In this case report, we illustrate for the first time the use of optical coherence tomography (OCT) in imaging the entire lesion in a patient with EQ. The results confirmed that the patient had in situ rather than invasive carcinoma. Consequently, non-invasive treatment with imiquimod 5%, a topical immunomodulator with antitumour and antiviral properties, was initiated ...

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    21. In vivo determination of epidermal thickness using high-definition optical coherence tomography

      In vivo determination of epidermal thickness using high-definition optical coherence tomography

      With great interest, we read the article of Mogensen and co-workers, which was published in this journal. 1 They studied 11 actinic keratoses and 23 basal cell carcinomas (< 2 mm thickness) using conventional optical coherence tomography (OCT, 20 μm lateral resolution) and 20-MHz ultrasound. OCT and 20-MHz ultrasound were compared with routine histology. The authors concluded that systematic comparison between mean OCT and 20-MHz ultrasound lesion thickness demonstrated that OCT is more accurate and less biased than 20-MHz ultrasound, even though both methods tended to overestimate the thickness of the lesion. Recently, high-definition OCT (HD-OCT) scanners have been developed providing ...

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      Mentions: Thilo Gambichler
    22. Optical coherence tomography (OCT) of collagen in normal skin and skin fibrosis

      Optical coherence tomography (OCT) of collagen in normal skin and skin fibrosis

      Optical coherence tomography (OCT) is a non-invasive imaging modality that is transforming clinical diagnosis in dermatology and other medical fields. OCT provides a cross-sectional evaluation of the epidermis and dermis and allows in vivo imaging of skin collagen. Upregulated collagen content is a key feature of fibrotic skin diseases. These diseases are often managed by the practitioner’s subjective assessment of disease severity and response to therapies. The purpose of this review is to provide an overview of the principles of OCT and present available evidence on the ability of OCT to image skin collagen in vivo for the diagnosis ...

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      Mentions: UC Davis
    23. Optical coherence tomography imaging of non-melanoma skin cancer undergoing imiquimod therapy

      Optical coherence tomography imaging of non-melanoma skin cancer undergoing imiquimod therapy

      Purpose To explore the application of optical coherence tomography (OCT) imaging of basal cell carcinomas (BCC) and actinic keratosis (AK) before, during and after imiquimod treatment and the ability of OCT to predict treatment outcome. Methods The study subjects were 20 patients with biopsy-verified BCC (9) or AK (11). Patients were OCT-scanned before, after 1 and 4 weeks of imiquimod treatment and after 3 months. Lesions were identified clinically and with OCT. Thickness and morphology of the lesions were recorded at each visit. Any remaining lesions were biopsied at follow-up. Results Complete data sets were available for 16 patients (8 ...

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