1. Articles in category: Dermatology

    265-288 of 529 « 1 2 ... 9 10 11 12 13 14 15 ... 20 21 22 »
    1. Full-field optical coherence tomography: a new technology for 3D high resolution skin imaging

      Full-field optical coherence tomography: a new technology for 3D high resolution skin imaging

      Background/Aims : Full-field optical coherence tomography (FFOCT) is a new imaging technology that can provide 3D micron-level resolution and is suited for high resolution imaging of biological tissue. The aim of this study is to evaluate its capacity and potential for imaging human epidermis and dermis and various skin pathologies in ex- and in-vivo conditions. Methods : Non fixed and fixed samples of normal and pathological skin and normal in-vivo skin were imaged with a FFOCT system and compared to histological slides. Results: The epidermis and adnexae, the collagen bundles of the dermis and the hypodermis could be identified through architectural ...

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    2. Visualization of hair follicles using high-speed optical coherence tomography based on a Fourier domain mode locking laser

      Visualization of hair follicles using high-speed optical coherence tomography based on a Fourier domain mode locking laser

      Abstract  In this study, a swept-source optical coherence tomography (SS-OCT) system with a Fourier domain mode locking (FDML) laser is proposed for a dermatology study. The homemade FDML laser is one kind of frequency-sweeping light source, which can provide output power of >20 mW and an output spectrum of 65 nm in bandwidth centered at 1300 nm, enabling imaging with an axial resolution of 12 μm in the OCT system. To eliminate the forward scans from the laser output and insert the delayed backward scans, a Mach-Zehnder configuration is implemented. Compared with conventional frequency-sweeping light sources, the FDML laser can ...

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    3. Qualitative investigation of fresh human scalp hair with full-field optical coherence tomography

      Qualitative investigation of fresh human scalp hair with full-field optical coherence tomography

      We have investigated depth-resolved cellular structures of unmodified fresh human scalp hairs with ultrahigh-resolution full-field optical coherence tomography (FF-OCT). The Linnik-type white light interference microscope has been home-implemented to observe the micro-internal layers of human hairs in their natural environment. In hair shafts, FF-OCT has qualitatively revealed the cellular hair compartments of cuticle and cortex layers involved in keratin filaments and melanin granules. No significant difference between black and white hair shafts was observed except for absence of only the melanin granules in the white hair, reflecting that the density of the melanin granules directly affects the hair color. Anatomical ...

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    4. High-resolution imaging of microvasculature in human skin in-vivo with optical coherence tomography

      High-resolution imaging of microvasculature in human skin in-vivo with optical coherence tomography

      In this paper, the features of the intensity-based Doppler variance (IBDV) method were analyzed systemically with a flow phantom. The effects of beam scanning density, flow rate and the time interval between neighboring A-lines on the performance of this method were investigated. The IBDV method can be used to quantify the flow rate and its sensitivity can be improved by increasing the time interval between the neighboring A-lines. A higher sensitivity IBDV method that applies the algorithm along the slower scan direction was proposed. In comparison to laser speckle imaging maps of blood flow, we demonstrated the ability of the ...

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    5. Research and System Development on Functional 3D Optical Tomography for Skin Cell Imaging

      Research and System Development on Functional 3D Optical Tomography for Skin Cell Imaging

      The investigators will obtain human skin specimen (sized approximately 1 cm x 1 cm) for dermatological surgical patients in National Taiwan University Hospital, after informed consent was obtained. Human skin keratinocytes, fibroblasts, and melanocytes will be cultured from the human skin specimen. The three dimensional images of these cultured cells will be observed by a ultra-high resolution 3-dimensional optical coherence tomography.

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    6. Optical features for chronological aging and photoaging skin by optical coherence tomography

      Optical features for chronological aging and photoaging skin by optical coherence tomography

      Abstract  The characteristics of skins in different aging processes were obtained by optical coherence tomography (OCT) single scattering model, and their optical parameters were analyzed quantitatively. Significant differences were found in epidermis thickness and attenuation coefficients in chronological aging skins and photonaging skins. These parameters can be served as indicators of skin type as well as the progress of aging. These results are valuable to the study of aging skin, and they could further help to understand the mechanism of aging.

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    7. Michelson Diagnostics announces £607k ($952k) investment to drive sales growth of revolutionary skin cancer scanner

      Michelson Diagnostics announces £607k ($952k) investment to drive sales growth of revolutionary skin cancer scanner

      Michelson Diagnostics (‘Michelson’) has announced an investment of £607k by shareholders Octopus Investments (‘Octopus’), Catapult Venture Managers (‘Catapult’) and individual investors, especially London Business Angels. The investment, which was an extension to the £1.92M investment in October 2011, will be used to further expand sales & support infrastructure in both USA and Europe, as Michelson’s installed base of ‘VivoSight’ skin cancer laser scanners continues to expand. The Company’s first product based on its patented multi‐beam optical coherence tomography (OCT) technology, the VivoSight scanner, is expected to revolutionise the market for the non‐invasive diagnosis and treatment of ...

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    8. Optical characters and texture maps of skin and the aging mechanism by use of multiphoton microscopy and optical coherence tomography

      Optical characters and texture maps of skin and the aging mechanism by use of multiphoton microscopy and optical coherence tomography

      Cutaneous aging is a complicated biological process affecting different constituents of skin, which can be divided into two types: the chronological aging and the photo-aging. The two cutaneous aging processes often co-exist accompanying with each other. The effects are often overlapped including changes in epithelium and dermis. The degeneration of collagen is a major factor in dermal alteration with aging. In this study, multiphoton microscopy (MPM) with its high resolution imaging and optical coherence tomography (OCT) with its depth resolved imaging were used to study the anti-aging dermatology in vivo. It was attempted to make the optical parameter and texture ...

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    9. Update and Clinical Use of Imaging Technologies for Pigmented Lesions of the Skin

      Update and Clinical Use of Imaging Technologies for Pigmented Lesions of the Skin

      The incidence of melanoma is on the rise, and early detection of disease is imperative to reduce mortality. Dermatologists are key players in the early detection of melanoma; however, some clinicians rely on their clinical examination without any additional diagnostic tools to make this important diagnosis. Certain patients, such as atypical nevus patients, have more complicated mole examinations, making the diagnosis of melanoma difficult, whereas some melanomas, such as amelanotic melanomas, can be diagnostically challenging. The goal of the clinician is to detect melanoma with the highest accuracy, while avoiding unnecessary biopsies. Using diagnostic melanoma tools as an adjunct to ...

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    10. Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin

      Integrated multimodal optical microscopy for structural and functional imaging of engineered and natural skin

      An integrated multimodal optical microscope is demonstrated for high-resolution, structural and functional imaging of engineered and natural skin. This microscope incorporates multiple imaging modalities including optical coherence (OCM), multi-photon (MPM), and fluorescence lifetime imaging microscopy (FLIM), enabling simultaneous visualization of multiple contrast sources and mechanisms from cells and tissues. Spatially co-registered OCM/MPM/FLIM images of multi-layered skin tissues are obtained, which are formed based on complementary information provided by different modalities, i.e., scattering information from OCM, molecular information from MPM, and functional cellular metabolism states from FLIM. Cellular structures in both the dermis and epidermis, especially different morphological ...

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    11. Influence of a pore-forming agent on swelling, network parameters, and permeability of poly(ethylene glycol)-crosslinked poly(methyl vinyl ether-co-maleic acid) hydrogels: Application in transdermal delivery systems

      Influence of a pore-forming agent on swelling, network parameters, and permeability of poly(ethylene glycol)-crosslinked poly(methyl vinyl ether-co-maleic acid) hydrogels: Application in transdermal delivery systems

      We characterized hydrogels, prepared from aqueous blends of poly(methyl vinyl ether-co-maleic acid) (PMVE/MA) and poly(ethylene glycol) (PEG 10,000 Daltons) containing a pore-forming agent (sodium bicarbonate, NaHCO3). Increase in NaHCO3 content increased the equilibrium water content (EWC) and average molecular weight between crosslinks (Mc) of hydrogels. For example, the %EWC was 731, 860, 1109, and 7536% and the Mc was 8.26, 31.64, 30.04, and 3010.00 × 105 g/mol for hydrogels prepared from aqueous blends containing 0, 1, 2, and 5% w/w of NaHCO3, respectively. Increase in NaHCO3 content also resulted in increased ...

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    12. OCT monitoring of cosmetic creams in human skin in vivo

      OCT monitoring of cosmetic creams in human skin in vivo

      Optical coherence tomography (OCT) is a tool currently used for noninvasive diagnosis of human disease as well as for monitoring treatment during or after therapy. In this study, OCT was used to examine penetration and accumulation of cosmetic creams on human hand skin. The samples varied in collagen content with one formulation containing soluble collagen as its primary active ingredient. Collagen is a major connective tissue protein that is essential in maintaining health vitality and strength of many organs. The penetration and localization of collagen in cosmetic creams is thought to be the main determinant of the efficacy of new ...

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    13. Advances in Diagnosing Non-melanoma Skin Cancers

      Advances in Diagnosing Non-melanoma Skin Cancers

      Biopsy remains the gold standard, but newer tools are useful adjuncts. More than 3.5 million skin cancers are diagnosed in more than 2 million patients in the United States each year, 1 and evidence from the American Academy of Dermatology (AAD) suggests that 20% of Americans will develop skin cancer. Basal cell and squamous cell carcinomas (BCC and SCC, respectively) are the two most common forms, accounting for about 96% of non-melanoma skin cancer (NMSC), and are easily treated, 2,3 with the latter more likely to spread to the lymph nodes. Both BCC and SCC are increasingly being ...

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    14. Determining The Extent Of A Structure On Or In The Skin Of A Subject

      Determining The Extent Of A Structure On Or In The Skin Of A Subject

      A method of and determining the extent of a structure (1), such as a non- melanoma skin cancer, in or on the skin of a subject, the method comprising the steps of: placing an index marker (3) on the skin adjacent to the structure (1); positioning an optical coherence tomography device (8) relative to the index marker; using the optical coherence tomography device (8) to image the structure (1) so as to create an image of a cross- section through the skin determining the position of an edge of the structure (1) in the image; and translating that position of ...

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    15. Optical Coherence-domain Imaging of Subcutaneous Human Blood Vessels in vivo

      Optical Coherence-domain Imaging of Subcutaneous Human Blood Vessels in vivo

      Experimental methods of Optical Coherence Tomography (OCT) are applied for two-dimensional mapping of subcutaneous human blood vessels. Structural images of in vivo human finger and human palm macro vessels (0.2-1.0 mm) before and after optical clearing using the modified low power rapid scanning optical delay line are presented. Images are scanned with 12 µm minimum spatial resolution. The described modifications enable to apply low power (0.4-0.5 mW), low noise broadband near infrared light source and to obtain structural images with detection of not only reflected but also multiply scattered coherence-gated photons. The achieved transcutaneous probing depth ...

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    16. Multimodal in vivo skin imaging with integrated optical coherence and multiphoton microscopy

      Multimodal in vivo skin imaging with integrated optical coherence and multiphoton microscopy
      In this paper we demonstrate high resolution, multimodal in vivo imaging of human skin using optical coherence (OCM) and multiphoton microscopy (MPM). These two modalities are integrated into a single instrument to enable simultaneous acquisition and co-registration. The system design and the OCM image processing architecture enable sufficient performance of both modalities for in vivo imaging of human skin. Examples of multimodal in vivo imaging are presented as well as time lapse imaging of blood flow in single capillaries. By making use of multiple intrinsic contrast mechanisms this integrated technique improves the ability to non-invasively visualize living tissue. Integrated OCM ...
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    17. Non-invasive instrument for skin cancer screening demonstrated

      Non-invasive instrument for skin cancer screening demonstrated
      Andor Press Release: Skin cancer is the most common form of human cancer with annual rates continuing to climb from their current estimate of just over three million new cases each year. Although all skin cancers share the likelihood of a favourable outcome if early diagnosis and complete resection are achieved, diagnosis is invasive, subjective, lengthy and expensive involving expert visual inspection, biopsy and histopathology. Now, a joint US-Dutch team under the direction of Anita Mahadevan-Jansen, Vanderbilt University, US, has developed a non-invasive probe capable of both morphological and biochemical characterization of skin cancers. The portable instrument combines a Raman ...
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    18. Feature Of The Week 12/4/11: Researchers in Hannover Germany Utilize OCT to Measure Skin Swelling Along Percutaneous Implants

      Feature Of The Week 12/4/11: Researchers in Hannover Germany Utilize OCT to Measure Skin Swelling Along Percutaneous Implants
      Researchers from the Leibniz University of Hannover (LUH), Laser Zentrum Hannover (LZH), and the Hannover Medical School (MHH) used OCT to measure skin swelling along percutaneous implants. An undistortion technique is proposed to compensate for the refractive distortions [1].Optical Coherence Tomography is a non invasive imaging modality recently used for taking high resolution optical biopsies of layered tissue structures such as the epidermis and the retina.As the OCT system captures optical distances rather than geometrical distances, the optical properties of the tissue introduce distortions into the OCT images. Therefore, model based image undistortion is an important step for ...
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    19. 3D optical coherence tomography for clinical diagnosis of nonmelanoma skin cancers

      3D optical coherence tomography for clinical diagnosis of nonmelanoma skin cancers

      High-resolution frequency domain optical coherence tomography (OCT) stands out amongst a range of novel dermatologic imaging technologies, with its good detection sensitivity around -100 dB, high measurement speeds allowing real-time image acquisition and its ability to acquire high definition cross-sectional and 3D tomograms of regions greater than 1 cm2, providing tissue information comparable to conventional histopathology without the need for any contrast agents. Typical axial and transverse resolutions of state-of-the-art OCT systems range between 1–10 µm and approximately 20 µm, respectively, depending on the employed wavelength region. This review investigates the significant progress accomplished in the field of dermatologic ...

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    20. Professor Julia Welzel hosts 1st International Optical Coherence Tomography User Meeting

      Professor Julia Welzel hosts 1st International Optical Coherence Tomography User Meeting

      Michelson Diagnostics Press Release - Optical Coherence Tomography, a non-invasive, real-time optical imaging modality, is an emergent in-vivo technique that allows high-resolution, 2- or 3-dimensional, cross-sectional visualisation of microstructural morphology of tissues. Based on near infrared interferometry, OCT provides depth-resolved images of tissues with resolution up to a few micrometers and depth up to several millimetres depending on tissue type 1. Recent advances in OCT technology have meant this promising technique is now emerging as an imaging tool for general clinical use. Newer OCT systems, built and cleared specifically for clinical use, have overcome many of the constraints of preceding research ...

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    21. Michelson Diagnostics announces £1.912M investment to drive sales growth of revolutionary skin cancer scanner

      Michelson Diagnostics announces £1.912M investment to drive sales growth of revolutionary skin cancer scanner
      Michelson Diagnostics Press Release - Michelson Diagnostics (‘Michelson’) has announced an investment of £1.912 million by shareholders Octopus Investments (‘Octopus’), Catapult Venture Managers (‘Catapult’) and individual investors from London Business Angels. The funds will be used to expand sales & support infrastructure in USA and Europe to respond to growing demand for Michelson’s revolutionary unique laser scanning technology, which can image skin and other surface tissue at a much higher resolution than ever before.   The Company’s first product based on its patented multi-beam optical coherence tomography (OCT) technology, the VivoSight scanner, is expected to revolutionise the market for the ...
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    22. The development of silk fibroin scaffolds using an indirect rapid prototyping approach: Morphological analysis and cell growth monitoring by spectral-domain optical coherence tomography

      The development of silk fibroin scaffolds using an indirect rapid prototyping approach: Morphological analysis and cell growth monitoring by spectral-domain optical coherence tomography
      To date, naturally derived biomaterials are rarely used in advanced tissue engineering (TE) methods despite their superior biocompatibility. This is because these native materials, which consist mainly of proteins and polysaccharides, do not possess the ability to withstand harsh processing conditions. Unlike synthetic polymers, natural materials degrade and decompose rapidly in the presence of chemical solvents and high temperature, respectively. Thus, the fabrication of tissue scaffolds using natural biomaterials is often carried out using conventional techniques, where the efficiency in mass transport of nutrients and removal of waste products within the construct is compromised. The present study identified silk fibroin ...
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    23. Confocal laser microscopy, optical coherence tomography and transonychial water loss for in vivo investigation of nails

      Confocal laser microscopy, optical coherence tomography and transonychial water loss for in vivo investigation of nails

      Background:  Nail disorders can be diagnostically challenging to the dermatologist. Non-invasive methods might help to avoid nail biopsies. More knowledge of the typical features of healthy nails with these techniques is needed for comparison with nail diseases.Objectives:  Objectives were to describe the typical morphology of healthy nails in optical coherence tomography (OCT) and confocal laser scanning microscopy (CLSM) and to examine the influence of exposure to water on OCT features, nail-thickness as well as on the transonychial water loss before and after a hand bath.Material and Methods:  In the first part healthy nail plates were investigated with OCT ...

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