1. Articles in category: Dermatology

    1-24 of 537 1 2 3 4 ... 21 22 23 »
    1. Full-field swept-source optical coherence tomography with phase-shifting techniques for skin cancer detection

      Full-field swept-source optical coherence tomography with phase-shifting techniques for skin cancer detection

      The EU-funded project VIAMOS1 proposes an optical coherence tomography system (OCT) for skin cancer detection, which combines full-field and full-range swept-source OCT in a multi-channel sensor for parallel detection. One of the project objectives is the development of new fabrication technologies for micro-optics, which makes it compatible to Micro-Opto-Electromechanical System technology (MOEMS). The basic system concept is a wafer-based Mirau interferometer array with an actuated reference mirror, which enables phase shifted interferogram detection and therefore reconstruction of the complex phase information, resulting in a higher measurement range with reduced image artifacts. This paper presents an experimental one-channel on-bench OCT system ...

      Read Full Article
    2. In vivo visualization of skin inflammation by optical coherence tomography and two-photon microscopy

      In vivo visualization of skin inflammation by optical coherence tomography and two-photon microscopy

      Inflammation is a non-specific immune response to injury intended to protect biological tissue from harmful stimuli such as pathogens, irritants, and damaged cells. In vivo optical tissue imaging has been used to provide spatial and dynamic characteristics of inflammation within the tissue. In this paper, we report in vivo visualization of inflammation in the skin at both cellular and physiological levels by using a combination of label-free two-photon microscopy (TPM) and optical coherence tomography (OCT). Skin inflammation was induced by topically applying lipopolysaccharide (LPS) on the mouse ear. Temporal OCT imaging visualized tissue swelling, vasodilation, and increased capillary density 30 ...

      Read Full Article
      Mentions: Ki Hean Kim
    3. A novel imaging approach to periocular basal cell carcinoma: in vivo optical coherence tomography and histological correlates

      A novel imaging approach to periocular basal cell carcinoma: in vivo optical coherence tomography and histological correlates

      Purpose Optical coherence tomography (OCT) is a non-invasive imaging method widely used in ophthalmology. Recent developments have produced OCT devices for imaging the skin. The purpose of this study was to investigate Fourier Domain OCT morphological features of periocular basal cell carcinoma (BCC) in correlation with conventional histopathology. Methods Consecutive patients with periocular nodular BCC were prospectively examined with VivoSight OCT (Michelson Ltd) prior to surgical excision. OCT slice mode images were analysed using criteria defined for conventional and HD-OCT; the images were correlated to haematoxylin and eosin stained histology sections. Results A total of 15 patients with periocular BCC ...

      Read Full Article
    4. Correlation between polarization sensitive optical coherence tomography and second harmonic generation microscopy in skin

      Correlation between polarization sensitive optical coherence tomography and second harmonic generation microscopy in skin

      Both polarization sensitive optical coherence tomography (PS-OCT) and second harmonic generation (SHG) microscopy are 3D optical imaging methods providing information related to collagen in the skin. PS-OCT provides birefringence information which is due to the collagen composition of the skin. SHG microscopy visualizes collagen fibers in the skin based on their SHG property. These two modalities have been applied to the same skin pathologies associated with collagen changes, but their relationship has not been examined. In this study, we tried to find the relationship by imaging the same skin samples with both modalities. Various parts of the normal rat skin ...

      Read Full Article
      Mentions: Ki Hean Kim
    5. High-definition optical coherence tomography intrinsic skin ageing assessment in women: a pilot study

      High-definition optical coherence tomography intrinsic skin ageing assessment in women: a pilot study

      Several non-invasive two-dimensional techniques with different lateral resolution and measurable depth range have proved to be useful in assessing and quantifying morphological changes in skin ageing. Among these, only in vivo microscopy techniques permit histometric measurements in vivo. Qualitative and quantitative assessment of chronological (intrinsic) age-related (IAR) morphological changes of epidermis, dermo-epidermal junction (DEJ), papillary dermis (PD), papillary-reticular dermis junction and reticular dermis (RD) have been performed by high-definition optical coherence tomography in real time 3-D. HD-OCT images were taken at the internal site of the right upper arm. Qualitative HD-OCT IAR descriptors were reported at skin surface, at epidermal ...

      Read Full Article
    6. Transformative clinical results with VivoSight in the diagnosis of Basal Cell Carcinoma: Data to be presented at the World Congress of Dermatology in Vancouver

      Transformative clinical results with VivoSight in the diagnosis of Basal Cell Carcinoma: Data to be presented at the World Congress of Dermatology in Vancouver

      Michelson Diagnostics, a medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces that data showing significant improvement in the diagnosis of basal-cell carcinoma (BCC) using its VivoSight multibeam OCT scanner will be presented at the World Congress of Dermatology (Vancouver, June 8-13). In addition to being an efficient, non-invasive way to diagnose BCC and other non-melanoma skin cancers, using the VivoSight OCT scanner has the potential to reduce biopsies and surgery, thereby reducing scarring for patients. Joint lead investigator, Dr Martina Ulrich, CMB Collegium, Berlin, Germany, will outline the results of this independent multi-centre, prospective clinical ...

      Read Full Article
    7. Skin substitute-assisted repair shows reduced dermal fibrosis in acute human wounds validated simultaneously by histology and optical coherence tomography

      Skin substitute-assisted repair shows reduced dermal fibrosis in acute human wounds validated simultaneously by histology and optical coherence tomography

      Skin substitutes are heterogeneous biomaterials designed to accelerate wound healing through provision of replacement extracellular matrix. Despite growing evidence for their use in chronic wounds, the role of skin substitutes in acute wound management and their influence upon fibrogenesis remains unclear. Skin substitute characteristics including biocompatibility, porosity and elasticity strongly influence cellular behaviour during wound healing. Thus, we hypothesise that structural and biomechanical variation between biomaterials may induce differential scar formation after cutaneous injury. The following human prospective cohort study was designed to investigate this premise. Four 5mm full-thickness punch biopsies were harvested from fifty volunteers. In all cases, site ...

      Read Full Article
    8. Cambridge role in new medical device

      Cambridge role in new medical device

      VivoSight Dx is aimed at dermatologists seeking an imaging system that will enhance their ability to make rapid and accurate diagnostic decisions for their patients. Michelson Diagnostics approached eg technology to undertake the aesthetic and detailed design of the product trolley and enclosure and the assembly methodology of the functional elements of the OCT system. eg and Michelson worked with dermatologists who were already using the first generation OCT system in order to gain insight into how the machine was used and how the system could be developed to enhance the experience of both the user and the patient. From ...

      Read Full Article
    9. Diagnostic Device For Dermatology With Merged Oct And Epiluminescence Dermoscopy

      Diagnostic Device For Dermatology With Merged Oct And Epiluminescence Dermoscopy

      Systems and methods for use of the imaging system are presented. In an embodiment, the imaging system includes a first optical path, a second optical path, a plurality of optical elements, a detector, and a processor. The first optical path guides a first beam of radiation associated with epiluminescence while the second optical path guides a second beam of radiation associated with optical coherence tomography.

      Read Full Article
    10. Michelson Diagnostics launches next generation OCT System – VivoSight Dx

      Michelson Diagnostics launches next generation OCT System – VivoSight Dx

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces the launch of VivoSight Dx, the Company’s second generation OCT system, at the German Society of Dermatology 48 th Congress 2015 (DDG 2015), 29 th April – 2 nd May 2015, Berlin. VivoSight Dx is aimed at dermatologists seeking an imaging system that will enhance their ability to make rapid, accurate diagnostic decisions for their patients. It is lighter, more compact and more mobile than the first generation OCT system, enabling its use in a consulting room at short notice. VivoSight Dx ...

      Read Full Article
    11. Landmark VivoSight OCT clinical study published in British Journal of Dermatology

      Landmark VivoSight OCT clinical study published in British Journal of Dermatology

      Results demonstrate clinical value of OCT in basal cell carcinoma diagnosis Michelson Diagnostics, the UK-based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces the publication on-line in the British Journal of Dermatology of the full results from an independent clinical study that demonstrates for the first time the clinical value of OCT in the diagnosis of basal cell carcinoma (BCC) 1 . This observational, prospective, multi-centre study was conducted using the Company’s VivoSight multi-beam OCT device. This study highlights that using VivoSight OCT is an efficient, non-invasive way to diagnose BCC and has the potential ...

      Read Full Article
    12. On the horizon: Optical imaging for cutaneous squamous cell carcinoma

      On the horizon: Optical imaging for cutaneous squamous cell carcinoma

      Background : Surgical resection with negative margins remains the standard of care for high-risk cutaneous squamous cell carcinoma (cSCC). However, surgical management is often limited by poor intraoperative tumor visualization and inability to detect occult nodal metastasis. The inability to intraoperatively detect microscopic disease can lead to additional surgery, tumor recurrence, and decreased survival. Methods : A comprehensive literature review was conducted to identify studies incorporating optical imaging technology in the management of cSCC (1/1/2000-11/1/2014). Results : Several innovative optical imaging techniques, Raman spectroscopy, confocal microscopy, and fluorescence imaging, have been developed for intraoperative surgical guidance. Fifty-seven studies review ...

      Read Full Article
    13. The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of non-pigmented basal cell carcinoma - an observational study

      The sensitivity and specificity of optical coherence tomography for the assisted diagnosis of non-pigmented basal cell carcinoma - an observational study

      Background The diagnostic criteria for basal cell carcinoma (BCC) using optical coherence tomography (OCT) have been described previously, but the clinical value of these findings has been unknown. Objective The aim of this study was to investigate the diagnostic value of OCT for BCC in a typical clinical setting. The primary efficacy endpoint was a diagnosis of BCC for each lesion. Secondary endpoints were the diagnosis of other possible conditions. Methods This was an observational, prospective, multi-centre study in which consecutive patients with non-pigmented pink lesions suspicious for BCC underwent clinical assessment, dermoscopy, and OCT with the diagnosis recorded at ...

      Read Full Article
    14. Taiwanese researchers find way to detect skin cancer early

      Taiwanese researchers find way to detect skin cancer early

      A research team at prestigious National Taiwan University (NTU) has developed a non-invasive technology that can help detect melanoma, the most deadly type of skin cancers, by up to six months earlier than usual. The team hopes its high-speed and high resolution optical coherence tomography scanner can receive medical certification by as early as 2017 so that it can put it into clinical use as soon as possible. Diagnosing cancer relies primarily on observing tissues and cells, and that is where the scanner can be useful in a timely way, said Shun Chia-tung, a doctor with National Taiwan University Hospital ...

      Read Full Article
    15. Internal fingerprint acquisition from optical coherence tomography fingertip scans

      Internal fingerprint acquisition from optical coherence tomography fingertip scans

      Current surface fingerprint scanners measure the surface topography of skin, resulting in vulnerabilities to surface skin erosion, distortion due to contact with the scanner, and fingerprint counterfeiting. An improved means of fingerprint acquisition is necessitated in these facts. By employing an imaging technique known as Optical Coherence Tomography to the human fingertip skin, a three-dimensional digital reconstruction of subsurface layers of skin can be used for the extraction of an internal fingerprint. The internal fingerprint is robust towards counterfeiting, damage, and distortion, thus providing a replacement for the surface fingerprint. However, OCT scans are corrupted by speckle noise and have ...

      Read Full Article
    16. Measuring skin aging using optical coherence tomography in vivo: a validation study

      Measuring skin aging using optical coherence tomography in vivo: a validation study

      Dermal and epidermal structures in human skin change during intrinsic and extrinsic aging. Epidermal thickness is one of the most often reported parameters for the assessment of skin aging in cross-sectional images captured by optical coherence tomography (OCT). We aimed to identify further parameters for the noninvasive measurement of skin aging of sun-exposed and sun-protected areas utilizing OCT. Based on a literature review, seven parameters were inductively developed. Three independent raters assessed these parameters using four-point scales on images of female subjects of two age groups. All items could be detected and quantified in our sample. Interrater agreement ranged between ...

      Read Full Article
    17. Internal fingerprint zone detection in optical coherence tomography fingertip scans

      Internal fingerprint zone detection in optical coherence tomography fingertip scans

      Optical coherence tomography (OCT) is a high-resolution imaging technology capable of capturing a three-dimensional (3-D) representation of fingertip skin. The papillary junction—a junction layer of skin containing the same topographical features as the surface fingerprint—is contained within this representation. The top edge of the papillary junction contains the topographical information pertinent to the internal fingerprint. Extracting the internal fingerprint from OCT fingertip scans has been shown to be possible. Currently, acquiring the internal fingerprint involves manually defining the region containing it. This manner of definition is inefficient. Perfect knowledge of the location of the papillary junction is hypothesized ...

      Read Full Article
    18. Michelson Diagnostics Appoints Peter Senger as Country Manager Germany

      Michelson Diagnostics Appoints Peter Senger as  Country Manager Germany

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces the appointment of Peter Senger as Country Manager Germany, with immediate effect. Peter, aged 46, has more than 25 years’ experience in sales and marketing and over 15 years of commercial experience in the medical device industry in Germany, with a track record of building early stage businesses with new and disruptive technologies. Most recently, Peter was Regional Business Manager at AngioDynamics, where he was instrumental in the introduction of the NanoKnife ® System into Germany and helped to secure reimbursement for the ...

      Read Full Article
    19. Functional optical coherence tomography of pigmented lesions

      Functional optical coherence tomography of pigmented lesions

      Background Cutaneous melanomas are diagnosed worldwide in 231 130 patients per year. The sensitivity and specificity of melanoma diagnosis expresses the need for an additional diagnostic method. Optical coherence tomography (OCT) has shown that it allows morphological (qualitative) description of image features and quantitative analysis of pathology related light scattering by means of the attenuation coefficient (μ oct ). Objective We hypothesize that OCT images of nevi will differ qualitatively and quantitatively from melanomas. Methods Forty lesions from 33 consecutive patients were imaged with OCT. After data acquisition, excision was performed. Epidermal layer thickness was measured and values of μ oct were extracted ...

      Read Full Article
    20. Vertically Integrated Array-type Mirau-based OCT System for early detection of skin pathologies

      Vertically Integrated Array-type Mirau-based OCT System for early detection of skin pathologies

      VIAMOS proposes an OCT microsystem able to revolutionize the field of microscopes for dermatology imaging. The aim of the project is to develop a new generation of Optical Coherence Tomography micro-system in order to help the diagnosis of skin pathologies thanks to a three dimensional image. The challenge is to provide a hand-held, low-cost and fully parallel spectral domain OCT micro-device. The consequence is a significant upgrade by adding new features such as heterodyne detection and integrated swept source. The project leans on the experience of 8 highly recognized European research institutes and companies such as the FEMTO-ST, University of ...

      Read Full Article
    21. Advances in non-invasive techniques as aids to the diagnosis and monitoring of therapeutic response in plaque psoriasis: a review

      Advances in non-invasive techniques as aids to the diagnosis and monitoring of therapeutic response in plaque psoriasis: a review

      Plaque psoriasis is a common, chronic, inflammatory disease with a multifactorial etiopathogenesis. Although its diagnosis is often based on clinical features, in ambiguous cases a biopsy with histopathologic confirmation may be necessary. Advanced high-definition imaging techniques may be useful in the study of skin properties in vivo and may facilitate therapeutic monitoring. Available imaging tools vary in their resolution, depth of penetration and visual representation (horizontal, vertical, three-dimensional), and in the type of skin structures visualized. The purpose of this review is to analyze a variety of non-invasive techniques that may assist in establishing definitive diagnoses, as well as in ...

      Read Full Article
    22. Improvement of Transdermal Delivery of Sumatriptan Succinate Using a Novel Self-dissolving Microneedle Array Fabricated from Sodium Hyaluronate in Rats

      Improvement of Transdermal Delivery of Sumatriptan Succinate Using a Novel Self-dissolving Microneedle Array Fabricated from Sodium Hyaluronate in Rats

      The purpose of the present study was to develop an alternative transdermal formulation containing sumatriptan succinate (SS) for the treatment of migraine. Novel self-dissolving SS-loaded microneedle arrays (MNs) were fabricated from sodium hyaluronate and their efficacy for transdermal delivery of SS was characterized. The resulting MNs maintained their skin piercing abilities for at least 30 min after being placed at a high relative humidity of 75%. Rapid release of SS from the MNs was also observed in vitro . Optical coherence tomography images demonstrated that MNs were able to successfully pierce into rat skin without any bending or cracking, and needles ...

      Read Full Article
    1-24 of 537 1 2 3 4 ... 21 22 23 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (1 articles) FEMTO-ST Institute
    2. (1 articles) University of Copenhagen
    3. (1 articles) University of Manchester
  4. People in the News

    1. (2 articles) Ki Hean Kim
    2. (1 articles) Gregor B. E. Jemec
    3. (1 articles) Andy Hill
    4. (1 articles) Luc Froehly
  5. OCT Companies in the News

    1. (2 articles) Michelson Diagnostics
  6. OCT Products in the News

    1. (2 articles) Michelson Diagnostics Vivosight