1. Articles in category: Dermatology

    1-24 of 482 1 2 3 4 ... 18 19 20 »
    1. Cross-evaluation of optimal glycerol concentration to enhance optical tissue clearing efficacy

      Cross-evaluation of optimal glycerol concentration to enhance optical tissue clearing efficacy

      Background/aims The efficacy of light therapeutic and diagnostic applications can be enhanced by employing optical tissue clearing (OTC) agents to minimize light scattering in tissue. This study aimed to investigate the optimal concentration of glycerol, so that it can be efficiently used as an OTC agent in dermatology. Methods Glycerol was topically applied to avoid the possibility of edema that could be caused by dermal injection. The efficacy of glycerol was quantitatively evaluated for various concentrations using optical coherence tomography (OCT) to evaluate light scattering and ultrasound imaging modality to evaluate collagen dissociation. Results The intensity in the OCT ...

      Read Full Article
    2. Optical coherence tomography: a potential tool for prediction of treatment response for port wine stain after photodynamic therapy

      Optical coherence tomography: a potential tool for prediction of treatment response for port wine stain after photodynamic therapy

      Response of port wine stain (PWS) to photodynamic therapy treatment (PDT) is variable and depends on treatment setting used and anatomic sites as well as on size and depth of ectatic vessels. Optical coherence tomography (OCT) is a non-destructive imaging modality which can reveal the layered structure of the upper part of the skin. The structural features of the PWS skin such as the diameter and depth of the blood vessels in different anatomic sites can be showed in the OCT images. In this study, the possible role of PWS skin structure in the response to PDT is assessed. 82 ...

      Read Full Article
    3. Noninvasive monitoring of photodynamic therapy on skin neoplastic lesions using the optical attenuation coefficient measured by optical coherence tomograph

      Noninvasive monitoring of photodynamic therapy on skin neoplastic lesions using the optical attenuation coefficient measured by optical coherence tomograph

      Photodynamic therapy (PDT) has become a promising alternative for treatment of skin lesions such as squamous cell carcinoma. We propose a method to monitor the effects of PDT in a noninvasive way by using the optical attenuation coefficient (OAC) calculated from optical coherence tomography (OCT) images. We conducted a study on mice with chemically induced neoplastic lesions and performed PDT on these lesions using homemade photosensitizers. The response of neoplastic lesions to therapy was monitored using, at the same time, macroscopic clinical visualization, histopathological analysis, OCT imaging, and OCT-based attenuation coefficient measurement. Results with all four modalities demonstrated a positive ...

      Read Full Article
    4. In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography: Diagnosis, Pathogenesis, and Treatment

      In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography: Diagnosis, Pathogenesis, and Treatment

      Miliaria profunda (MP) is a condition of sweat duct obstruction manifesting with generalized papular eruption and anhidrosis. 1 , 2 Using imaging with high-definition optical coherence tomography (HD-OCT), we identified, in vivo, the depth of lesions in MP and the likely location of sweat duct obstruction. To our knowledge, this is the first time such an evaluation has been performed.

      Read Full Article
    5. Feature Of The Week 11/16/14: In Vivo Analysis of Burns in a Mouse Model using Spectroscopic OCT

      Feature Of The Week 11/16/14: In Vivo Analysis of Burns in a Mouse Model using Spectroscopic OCT

      Evaluation of burn severity is a significant clinical problem with over 2 million burns reported each year in the United States [1]. The magnitude of this clinical need has inspired the development of many technologies to assess burn depth, but none of these have been widely adopted as clinical judgment still relies primarily on visual inspection, with an accuracy of about 70% [2]. A recent study by researchers at Duke University used spectroscopic optical coherence tomography (OCT) to evaluate burned animal tissues in vivo. Spectroscopic OCT is an extension of conventional OCT that can measure depth-resolved scattering and absorption spectra ...

      Read Full Article
    6. In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography: Diagnosis, Pathogenesis, and Treatment

      In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography: Diagnosis, Pathogenesis, and Treatment

      Miliaria profunda (MP) is a condition of sweat duct obstruction manifesting with generalized papular eruption and anhidrosis. 1 , 2 Using imaging with high-definition optical coherence tomography (HD-OCT), we identified, in vivo, the depth of lesions in MP and the likely location of sweat duct obstruction. To our knowledge, this is the first time such an evaluation has been performed.

      Read Full Article
    7. Fabrication of a novel dissolving polymer microneedle patch for transdermal drug delivery

      Fabrication of a novel dissolving polymer microneedle patch for transdermal drug delivery

      Polymer microneedles (MNs) have gained increasing attention as a minimally invasive method for efficiently delivering drugs and vaccines in a patient-friendly manner. Herein, an easy and mild process with O2 plasma treatment was used to fabricate polyvinylpyrrolidone (PVP)/polyvinyl alcohol (PVA) MN patches, and efficient, sustained transdermal delivery was achieved. The diffusion rate of the entrained molecules could be controlled by adjusting the ratio of PVP/PVA. Optical coherence tomography was used to monitor the in vitro penetration in real time and to measure the penetration depth. Rhodamine 6G and fluorescein isothiocyanate-labeled bovine serum albumin (BSA-FITC) were used to explore ...

      Read Full Article
    8. In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea

      In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea

      Optical coherence tomography (OCT) is a noninvasive imaging technique that allows real-time high-definition cross-sectional visualization of tissues. Conventional OCT was introduced in dermatology in 1997 and has shown benefit in evaluating malignant neoplasms and inflammatory skin disorders. 1 , 2 High-definition OCT (HD-OCT) scanners have recently been developed; they provide a higher resolution than conventional OCT and horizontal, in additional to vertical, sectional imaging, which conventional OCT does not provide.

      Read Full Article
    9. MedLumics Introduces NITID Skin Imaging System at EADV

      MedLumics Introduces NITID Skin Imaging System at EADV

      MedLumics, a medical imaging company specializing in advanced optical coherence tomography (OCT) technology, debuted its NITID TM skin imaging system at the 23 rd Annual European Academy of Dermatology and Venereology Congress in Amsterdam. NITID is a handheld diagnostic device designed to help dermatologists quickly and minimally invasively diagnose skin cancer. Once approved by regulatory bodies, it will be the first point-of-care OCT imaging device that can produce dynamic, real-time, high-resolution diagnostic images with tissue penetration capability of up to two millimeters. “NITID is the result of a decade of research in optical miniaturization technology, and we are thrilled to ...

      Read Full Article
    10. Three-Dimensional High Definition-Optical Coherence Tomography Image Acquisition Procedure For Basal Cell Carcinoma

      Three-Dimensional High Definition-Optical Coherence Tomography Image Acquisition Procedure For Basal Cell Carcinoma

      We read with great interest the paper "Histopathological correlates of basal cell carcinoma in slice and en-face imaging modes of high-definition optical coherence tomography" by Gambichler et al. Optical Coherence Tomography (OCT) seems an interesting technology to study skin tumours. In particular it has been found helpful for basal cell carcinoma (BCC) diagnosis in several investigations. 

      Read Full Article
    11. Great EADV meeting in Amsterdam | Eduardo Margallo

      Great EADV meeting in Amsterdam | Eduardo Margallo

      MedLumics demonstrated NITID™, a new skin imaging solution providing simultaneous Optical Coherence Tomography and video dermoscopy in a hand-held battery-operated system. This revolution in skin care, designed for the daily dermatology practice, will be commercially available soon.

      Read Full Article
    12. Michelson Diagnostics launches new improved version of VivoSight OCT scanner with Micro-Camera to aid skin cancer diagnosis

      Michelson Diagnostics launches new improved version of VivoSight OCT scanner with Micro-Camera to aid skin cancer diagnosis

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, announces the launch of a new improved version of its innovative VivoSight OCT scanner at the European Academy of Dermatology and Venereology (EADV) Annual Meeting, 8-12 October, Amsterdam. The VivoSight scanner probe is now equipped with a new Micro Camera that provides the user with a real-time, colour, magnified view of the skin lesion being scanned. The new Micro Camera image is shown simultaneously with the vertical and en face OCT images, making the VivoSight scanner the only dermatological clinical OCT device to provide ...

      Read Full Article
    13. Ex-vivo multi-modal microscopy of healthy skin

      Ex-vivo multi-modal microscopy of healthy skin

      The thorough characterization of skin samples is a critical step in investigating dermatological diseases. The combination of depth-sensitive anatomical imaging with molecular imaging has the potential to provide vast information about the skin. In this proof-of-concept work we present high-resolution mosaic images of skin biopsies using Optical Coherence Tomography (OCT) manually co-registered with standard microscopy, bi-dimensional Raman spectral mapping and fluorescence imaging. A human breast skin sample, embedded in paraffin, was imaged with a swept-source OCT system at 1310 nm. Individual OCT volumes were acquired in fully automated fashion in order to obtain a large field-of-view at high resolution (~10 ...

      Read Full Article
    14. Observation and analysis on skin cancer induced by UVB irradiation using optical coherence tomography

      Observation and analysis on skin cancer induced by UVB irradiation using optical coherence tomography

      Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the prevalent skin cancers, which have a quite high incidence in the white race. In recent years, however, their incidences have been increasing in the yellow race, resulting in a great threat to the public health. According to researches, chronics UVB irradiation (280nm~320nm) is the major culprit of skin cancer in humans. In our study, the model of UVB induced skin cancer was established firstly. Optical coherence tomography (OCT) combined with the histopathology was exploited to monitor the morphologic and histological changes of the process of UVB induced skin ...

      Read Full Article
    15. Automated identification of basal cell carcinoma by polarization-sensitive optical coherence tomography

      Automated identification of basal cell carcinoma by polarization-sensitive optical coherence tomography

      We report an automated classifier to detect the presence of basal cell carcinoma in images of mouse skin tissue samples acquired by polarization-sensitive optical coherence tomography (PS-OCT). The sensitivity and specificity of the classifier based on combined information of the scattering intensity and birefringence properties of the samples are significantly higher than when intensity or birefringence information are used alone. The combined information offers a sensitivity of 94.4% and specificity of 92.5%, compared to 78.2% and 82.2% for intensity-only information and 85.5% and 87.9% for birefringence-only information. These results demonstrate that analysis of the ...

      Read Full Article
    16. In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography

      In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography

      Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology.

      Read Full Article
    17. High-definition optical coherence tomography of melanocytic skin lesions

      High-definition optical coherence tomography of melanocytic skin lesions

      High-definition optical coherence tomography and the corresponding vertically sectioned histology of a compound naevus. High-definition optical coherence tomography (HD-OCT) scanners have recently been developed. We assessed micromorphological HD-OCT correlates of benign naevi (BN) and malignant melanoma (MM). 28 BN and 20 MM were studied using HD-OCT and histology. Epidermal honeycomb/cobblestone pattern, regular junctional cell nests, and edged papillae are more often observed in BN, whereas fusion of rete ridges, pagetoid cells and junctional and/or dermal nests with atypical cells are more frequently seen in MM. A high overlap of HD-OCT features in BN and MM was observed and ...

      Read Full Article
    18. Optical coherence tomography in the diagnosis of basal cell carcinoma

      Optical coherence tomography in the diagnosis of basal cell carcinoma

      Since its introduction in dermatology in the late 1990s optical coherence tomography (OCT) has been used to study many skin diseases, in particular non-melanoma skin cancer and it s precursors. Special attention has been paid to superficial basal cell carcinoma (BCC), and a number of smaller observational studies have been published. The diagnostic criteria for BCC of these studies are systematically reviewed. A systemic review of English language studies was performed using PubMed, Google Scholar and Royal Danish Library, to search for primary papers on OCT and BCC. The references of retrieved papers were searched by hand for further relevant ...

      Read Full Article
    19. MULTIMODAL OPTOSPECTRAL INVESTIGATION OF MELANOCYTIC SKIN LESIONS: A CORRELATION STUDY USING OPTICAL COHERENCE TOMOGRAPHY AND DERMOSCOPY

      MULTIMODAL OPTOSPECTRAL INVESTIGATION  OF MELANOCYTIC SKIN LESIONS: A CORRELATION  STUDY USING OPTICAL COHERENCE TOMOGRAPHY  AND DERMOSCOPY

      Optical coherence tomography (OCT) is one of the best options, in terms of skin penetration depth and resolution, for skin lesion diagnosis. This study reports on the use of OCT for the in vivo imaging analysis of 67 melanocytic skin lesions in 34 patients. The OCT results have been compared with the dermoscopy – the standard non-invasive, visible-light-based skin imaging technique. The variations of the OCT imaging correlate with the dermoscopic pattern and presence of dermoscopic structures, like globules, blotches and regression areas. Our study shows that OCT is a promising non-invasive imaging technique for the diagnosis of skin lesions and ...

      Read Full Article
    20. Future Prospects in Dermatologic Applications of Lasers, Nanotechnology, and Other New Technologies

      Future Prospects in Dermatologic Applications of Lasers, Nanotechnology, and Other New Technologies

      We review novel technologies with diagnostic and therapeutic applications in dermatology. Among the diagnostic techniques that promise to become part of dermatologic practice in the future are optical coherence tomography, multiphoton laser scanning microscopy, Raman spectroscopy, thermography, and 7-T magnetic resonance imaging. Advances in therapy include novel light-based treatments, such as those applying lasers to new targets and in new wavelengths. Devices for home therapy are also appearing. We comment on the therapeutic uses of plasma, ultrasound, radiofrequency energy, total reflection amplification of spontaneous emission of radiation, light stimulation, and transepidermal drug delivery. Finally, we mention some basic developments in ...

      Read Full Article
    21. Differentiating allergic and irritant contact dermatitis by high-definition optical coherence tomography: a pilot study

      Differentiating allergic and irritant contact dermatitis by high-definition optical coherence tomography: a pilot study

      Differentiation of allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD) is important because of different management requirements. Various non-invasive tests have been used in an attempt to improve diagnosis. In irritant dermatitis, thickening of the epidermis has been a constant finding. High-Definition Optical Coherence Tomography (HD-OCT) is a non-invasive real-time three-dimensional imaging technique with cellular resolution for which an adapted algorithmic method for pattern analysis discriminating inflammatory skin diseases has been proposed. The aim of this study was threefold. (1) To evaluate the correlation between HD-OCT features and clinical scores of allergic and irritant patch test reactions. (2) To ...

      Read Full Article
    22. Imaging of collagen deposition disorders using optical coherence tomography

      Imaging of collagen deposition disorders using optical coherence tomography

      Background Collagen deposition disorders such as hypertrophic scars, keloids and scleroderma can be associated with significant stigma and embarrassment. These disorders often constitute considerable impairment to quality of life, with treatment posing to be a substantial challenge. Optical coherence tomography (OCT) provides a non-invasive, easily applicable bedside optical imaging method for assessment of the skin. It is hypothesized that OCT imaging may be useful in assessing fibrosis to avoid additional biopsies that could potentially worsen the scarring. Method Thirty-three patients with ordinary scars, hypertrophic scars, keloid scarring, lichen sclerosus et atrophicus and localized or systemic scleroderma were recruited for this ...

      Read Full Article
    1-24 of 482 1 2 3 4 ... 18 19 20 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (1 articles) Tsinghua University
    2. (1 articles) Yonsei University
  4. People in the News

    1. (1 articles) Anderson Z. Freitas
    2. (1 articles) Anne Latrive