1. Articles in category: Dermatology

    1-24 of 1093 1 2 3 4 ... 44 45 46 »
    1. Optical-Coherence Tomography for the Non-invasive Diagnosis and Subtyping of Basal Cell Carcinoma

      Optical-Coherence Tomography for the Non-invasive Diagnosis and Subtyping of Basal Cell Carcinoma

      To date, the diagnosis and subtyping of basal cell carcinoma (BCC) is verified with histopathology which requires a biopsy. Because this technique is invasive, new non-invasive strategies have been developed, including Optical Coherence Tomography (OCT). This innovative technique enables microscopically detailed examination of lesions, which is useful for diagnosing and identification of various subtypes of BCC. The diagnostic value of the VIVOSIGHT OCT in daily clinical practice, has not been established to date.

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    2. In vivo optical coherence tomography-guided photodynamic therapy for skin pre-cancer and cancer

      In vivo optical coherence tomography-guided photodynamic therapy for skin pre-cancer and cancer

      Background: The primary aim of this prospective study is to demonstrate the technical feasibility of OCT to map real tumor margins and to monitor skin changes that occurred post- PDT. Moreover, to optimize PDT efficacy based on the relationship between measured OCT features and treatment outcome. Material and methods: A series of 12 patients with overall 18 facial skin lesions were investigated by OCT before surface illumination by PDT to determine tumor free margins. Monitoring of the healing process was undertaken at 3, 6 and 12 months post-PDT. Parameters measured by the in vivo OCT during healing phase were the ...

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    3. Automatic quantitative analysis of structure parameters in the growth cycle of artificial skin using optical coherence tomography

      Automatic quantitative analysis of structure parameters in the growth cycle of artificial skin using optical coherence tomography

      Significance: Artificial skin (AS) is widely used in dermatology, pharmacology, and toxicology, and has great potential in transplant medicine, burn wound care, and chronic wound treatment. There is a great demand for high-quality AS product and a non-invasive detection method is highly desirable. Aim: To quantify the constructure parameters (i.e., thickness and surface roughness) of AS samples in the culture cycle and explore the growth regularities using optical coherent tomography (OCT). Approach: An adaptive interface detection algorithm is developed to recognize surface points in each A-scan, offering a rapid method to calculate parameters without constructing OCT B-scan pictures and ...

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    4. Assessing Light and Energy-Based Therapy by Optical Coherence Tomography and Reflectance Confocal Microscopy: A Randomized Trial of Photoaged Skin

      Assessing Light and Energy-Based Therapy by Optical Coherence Tomography and Reflectance Confocal Microscopy: A Randomized Trial of Photoaged Skin

      Background and Objectives: Image-guided quantitative and semi-quantitative assessment of skin can potentially evaluate treatment efficacy. Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) are ideal for this purpose. This study assessed clinically relevant statistical changes in RCM and OCT features in photoaged skin after light and energy-based therapy. Methods: Novel statistical analyses were performed using OCT and RCM data collected during a previously published trial: a 12-week study of female décolleté skin randomized to four areas treated with thulium laser (L), photodynamic therapy (PDT), combined L-PDT, and control. Eight semi-quantitative RCM scores of photodamage and OCT measurements of ...

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    5. Methods of Non-Invasive In Vivo Optical Diagnostics in the Assessment of Structural Changes in the Skin Induced by Ultraviolet Exposure in an Experimental Model

      Methods of Non-Invasive In Vivo Optical Diagnostics in the Assessment of Structural Changes in the Skin Induced by Ultraviolet Exposure in an Experimental Model

      Background: This paper demonstrates the use of optical diagnostic methods to assess the dynamic skin changes observed in acute and chronic exposure to ultraviolet (UV) radiation in vivo. Methods: Firstly, in order to initiate photoaging (chronic UV exposure), animals ( n = 40) were divided into two groups: chronic UV exposure ( n = 30), and control ( n = 10; without irradiation). Photoaging in animals was induced by chronic repeated exposure to UVA radiation three times per week, for 12 weeks continuously, while the UV dose increased stepwise over the course of the experiment (55 minimal erythema doses (MED) in total). Laser fluorescence spectroscopy (LFS ...

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    6. In vivo optical coherence tomography in assessment of suspicious facial lesions: A prospective study

      In vivo optical coherence tomography in assessment of suspicious facial lesions: A prospective study

      Background: Skin cancer continues to be the most common cancer in the Caucasian population. Over the past two decades, researchers around the world started assessing the possibility of diagnosing tissue pathologies by using optical systems. In this study, we aimed to use in vivo optical coherence tomography (OCT) technology to describe the morphologic features of normal and pathologic skin conditions. Materials and methods: In this study, 72 patients with suspected skin pre-cancer/cancer were recruited. The lesions were subjected to in vivo OCT scanning using compact size probe. The main scanned areas were the centre of the lesion, periphery of ...

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    7. Dermoscopy, confocal microscopy and optical coherence tomography features of main inflammatory and autoimmune skin diseases: A systematic review

      Dermoscopy, confocal microscopy and optical coherence tomography features of main inflammatory and autoimmune skin diseases: A systematic review

      Background/objectives: Non-invasive skin imaging features of main skin inflammatory and autoimmune diseases have been reported, although a comprehensive review of their correlation with histopathologic features is currently lacking. Therefore, the aim of this paper was to review the correlation of dermoscopic, reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) criteria of main inflammatory and autoimmune skin diseases with their corresponding histopathologic criteria correlation. Methods: Studies on human subjects affected by main inflammatory and autoimmune diseases, defining the correlation of dermoscopic, RCM or OCT with histopathologic criteria, were included in the review. Five groups of diseases were identified and ...

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    8. Line-field Confocal Optical Coherence Tomography of pyogenic granulomas in children: report of two cases

      Line-field Confocal Optical Coherence Tomography of pyogenic granulomas in children: report of two cases

      Pyogenic granuloma (PG) is a common benign vascular tumors in children. 1 Most of the time diagnosis is straightforward but sometimes a biopsy may be necessary to confirm diagnosis. In these cases, a non-invasive imaging method could be helpful. We present the first Line-field Confocal Optical Coherence Tomography (LC-OCT) images of PG in two children. LC-OCT is a non-invasive method for skin assessment, allowing evaluation of skin lesion up to a depth of about ~500 µm (upper dermis).

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    9. Line-field confocal optical coherence tomography for the in-vivo real-time diagnosis of different stages of keratinocyte skin cancer: a preliminary study

      Line-field confocal optical coherence tomography for the in-vivo real-time diagnosis of different stages of keratinocyte skin cancer: a preliminary study

      Background: The treatment of keratinocyte cancers (KC) strictly depends on their differentiation and invasiveness. Non-invasive diagnostic techniques can support the diagnosis in real-time, avoiding unnecessary biopsies. This study aimed to preliminarily define main imaging criteria and histological correlations of actinic keratosis (AK), Bowen's disease (BD) and squamous cell carcinoma (SCC) using the novel device line-field confocal optical coherence tomography (LC-OCT). Methods: Dermoscopy and LC-OCT images of 73 histopathologically confirmed lesions (46 AKs, 11 BD and 16 SCCs) were included in the study. Exemplary lesions (10 AKs, 5 BD and 5 SCCs) were additionally investigated with optical coherence tomography and ...

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    10. Vascular characteristics of port wine birthmarks as measured by dynamic optical coherence tomography

      Vascular characteristics of port wine birthmarks as measured by dynamic optical coherence tomography

      Background: Port wine birthmarks (PWB) are congenital capillary malformations. Vessel characteristics, such as diameter and depth, may impact presentation and outcomes. They can be imaged using dynamic optical coherence tomography (D-OCT), a high-resolution, non-invasive imaging method. Purpose: We conducted a cross-sectional observational study to measure in-vivo vascular characteristics as a function of PWB color. Methods: Patients undergoing treatment for PWB were recruited from three sites. PWB were classified by color, and D-OCT images with calculations were obtained. Results: 108 patients were enrolled. Mean age correlated with PWB color, with younger patients having lighter and older patients having darker birthmarks (p ...

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    11. Subcutaneous sweat pore estimation from optical coherence tomography

      Subcutaneous sweat pore estimation from optical coherence tomography

      Sweat pore, one of the level 3 features of fingerprint, has attracted much attention in fingerprint recognition. Traditional sweat pores on surface fingerprint are unclear or blurred when fingers are stained or damaged. Subcutaneous sweat pores, as cross section of the sweat glands, are resistant to external interferences. With 3D fingertip information measured by optical coherence tomography (OCT), the subcutaneous sweat pore estimation from OCT volume data is investigated. First, an adaptive subcutaneous pore image reconstruction method is proposed. It utilizes the skin surface and viable epidermis junction as reference and realizes depth-adaptive pore image reconstruction. Second, a dilated U-Net ...

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    12. Quantitative Evaluation of Damages to Retinal Capillaries Caused by Half-dose and Half-time Photodynamic Therapy with Optical Coherent Tomographic Angiography

      Quantitative Evaluation of Damages to Retinal Capillaries Caused by Half-dose and Half-time Photodynamic Therapy with Optical Coherent Tomographic Angiography

      Purpose : To determine and compare retinal capillaries damages in patients with chronic central serous chorioretinopathy (CSC) after half-dose and half-time photodynamic therapy (PDT) based on optical coherence tomographic angiography (OCTA). Methods : Thirty-three eyes of 33 patients and 32 eyes of 32 patients with active CSC were treated with half-dose PDT and half-time PDT respectively and followed up for 3 months. Fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) were performed at baseline; best corrected visual acuity (BCVA) and OCTA were performed at baseline, 3-day, 7-day, 14-day, 1-month, and 3-month follow-up visits. Results : Twenty-eight patients in half-dose group and 27 ...

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    13. Line-field confocal optical coherence tomography in molluscum contagiosum: a case series

      Line-field confocal optical coherence tomography in molluscum contagiosum: a case series

      Molluscum contagiosum (MC) is a common skin infection caused by a poxvirus, generally observed in children and young, sexually active, adults. MC diagnosis is usually clinical and based on the observation of asymptomatic, small, flesh-colored papules with a characteristic central umbilication. Dermoscopy enhances the diagnostic accuracy of MC showing within the lesion, the presence of yellowish-white, roundish, single or multiple areas (also called "pores" or "orifices", corresponding to the clinical umbilication) surrounded by fine, linear, and blurred vessels (1). In some cases, the diagnosis may require the histopathological confirmation.

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    14. Efficacy Assessment of a TCA/H2O2 Compositum for Skin Aging Treatment by Confocal Laser Microscopy and Optical Coherence Tomography

      Efficacy Assessment of a TCA/H2O2 Compositum for Skin Aging Treatment by Confocal Laser Microscopy and Optical Coherence Tomography

      Skin ageing is a complex phenomenon linked to intrinsic and extrinsic factors, such as ultraviolet exposure, smoking, or pollution, 1-4 which involves all skin layers. 5,6,7 Ageing is characterised by a reduction of collagen synthesis, 4,8,9 a decreased hydration, 5,6 epidermal thickness variations 7 , and an accelerated breakdown and disorganization of collagen fibers 4,8,9 as well as loss of skin elasticity.

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    15. Evaluation of a 3.8-µm laser-induced skin injury and their repair with in vivo OCT imaging and noninvasive monitoring

      Evaluation of a 3.8-µm laser-induced skin injury and their repair with in vivo OCT imaging and noninvasive monitoring

      To explore a 3.8-µm laser-induced damage and wound healing effect, we propose using optical coherence tomography (OCT) and a noninvasive monitoring-based in vivo evaluation method to quantitatively and qualitatively analyze the time-dependent biological effect of a 3.8-µm laser. The optical attenuation coefficient (OAC) is computed using a Fourier-domain algorithm. Three-dimensional (3-D) visualization of OCT images has been implemented to visualize the burnt spots. Furthermore, the burnt spots from the 3-D volumetric data was segmented and visualized, and the quantitative parameters of the burnt spots, such as the mean OACs, areas, and volumes, were computed. Then, OCT ...

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    16. Investigating the depolarization property of skin tissue by degree of polarization uniformity contrast using polarization-sensitive optical coherence tomography

      Investigating the depolarization property of skin tissue by degree of polarization uniformity contrast using polarization-sensitive optical coherence tomography

      The depolarization property of skin has been found to be important for skin cancer detection. Previous techniques based on light polarization lack the capability of depth differentiation. Polarization-sensitive optical coherence tomography (PS-OCT) has the advantage of both depth-resolved 3D imaging and high sensitivity to polarization. In this study, we investigate the depolarization property of skin tissue using PS-OCT, especially with the degree of polarization uniformity (DOPU) contrast. Well designed skin phantoms with various surface roughness levels and optical properties mimicking skin are imaged by PS-OCT and the DOPU values are quantified. The result shows a correlation between DOPU and surface ...

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    17. Manually scanned single fiber optical coherence tomography for skin cancer characterization

      Manually scanned single fiber optical coherence tomography for skin cancer characterization

      Optical coherence tomography (OCT) is a cross-sectional imaging modality based on low coherence light interferometry. Within dermatology, it has found applications for in vivo diagnostic imaging purposes, as well as to guide Mohs micrographic surgery (MMS), due to its ability to visualize skin morphology up to several millimeters in depth. However, standard OCT probes have a large footprint and capture an extended area of the skin, making it difficult to precisely pinpoint clinically relevant location being imaged. Mohs surgeons stand to benefit from a handheld in vivo imaging device that can accurately trace surgical margins. In this study, we demonstrate ...

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    18. Optical Coherence Tomography for Melanoma Detection (Book Chapter)

      Optical Coherence Tomography for Melanoma Detection (Book Chapter)

      Tissue contrast in optical coherence tomography (OCT) images is generated by the intrinsic characteristics that are proportional to the density, size, and shape of tissue microstructures. Extraction of tissue optical properties from OCT images is therefore a generic method for obtaining quantitative information about tissue microstructure. The sensitivity and specificity of conventional OCT by assessing morphology only for melanoma detection is lower than anticipated. The aggregation of the predominant optical properties that contribute to OCT image formation diminishes the specificity of melanoma detection due to interrelationships of these properties. Importantly, the optical properties come at no additional cost as they ...

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    19. Line-field confocal optical coherence tomography of actinic keratosis: a case series

      Line-field confocal optical coherence tomography of actinic keratosis: a case series

      Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive imaging technique that was recently developed, combining high penetration depth (up to 500-µm, approaching that of conventional OCT) with high isotropic resolution [lateral: 1.3 µm; axial: 1.1 µm - similar to that of reflectance confocal microscopy (RCM)]. 1 .

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    20. Imaging system reads fingers at subdermal level

      Imaging system reads fingers at subdermal level

      A new tool developed by researchers at the PSL Research University (Paris, France; www.psl.eu/en ), the Polish Academy of Sciences (Warsaw, Poland; www.pan.pl ), and Norwegian University of Science (Gjøvik, Norway; www.ntnu.edu ), as described in the research paper “Compact and Mobile Full-Field Optical Coherence Tomography Sensor for Subsurface Fingerprint Imaging ( bit.ly/VSD_FNGPR ),” images fingerprints at the subdermal level. According to the researchers, this new method overcomes challenges to accurate fingerprinting like moisture or particulate matter, equipment damage, and even artificial fingerprints. Skin layers around 200 to 400 µm beneath the outer layer compose ...

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      Mentions: Thorlabs
    21. Combining Nd:YAG laser with optical coherence tomography for nonsurgical treatment of basal cell carcinoma

      Combining Nd:YAG laser with optical coherence tomography for nonsurgical treatment of basal cell carcinoma

      Background: Effective and aesthetically appealing management options are needed for basal cell carcinoma (BCC), the most common skin cancer. The Nd:YAG laser shows promise, but most studies use biopsy to demonstrate tumor clearance. Optical coherence tomography (OCT) could allow good tumor margin control while enabling recurrence monitoring. Objective: Determine the efficacy of the Nd:YAG laser to treat BCCs while controlling for tumor margin with OCT. Methods: A 1064-nm Nd:YAG laser was applied to treat 119 BCCs in 102 patients, where tumor margins were approximated using OCT. Lesions were treated every 2 months until no residual tumor remained ...

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    22. Known and new facts on basal cell carcinoma

      Known and new facts on basal cell carcinoma

      Basal cell carcinoma (BCC) is the most common malignant tumor in light-skinned people and amounts to about 75 % of all cases of skin cancer. Increasing incidence rates have been reported for decades all over the world. The main risk factors include UV radiation, male sex, light skin type, advanced age, long-term immunosuppression, a positive individual or family history, and certain genodermatoses. BCC metastasizes only rarely, and its mortality is low, but it is associated with significant morbidity. Genetic mutations especially in the hedgehog pathway play an important role in BCC pathogenesis. Non-invasive procedures such as optical coherence tomography or confocal ...

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    1-24 of 1093 1 2 3 4 ... 44 45 46 »
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