1. Articles in category: Dermatology

    1-24 of 738 1 2 3 4 ... 29 30 31 »
    1. Viscoelastic Behavior of Tissues and Implant Materials: Estimation of the Elastic Modulus and Viscous Contribution Using Optical Coherence Tomography and Vibrational Analysis

      Viscoelastic Behavior of Tissues and Implant Materials: Estimation of the Elastic Modulus and Viscous Contribution Using Optical Coherence Tomography and Vibrational Analysis

      Recently, we have reported use of Optical Coherence Tomography (OCT) and vibrational analysis to determine the resonant frequency of a material from which the moduli of decellularized dermis, pig skin, silicone rubber and chemically modified dermis were calculated. In this paper, we present data on viscoelastic mechanical properties of extracellular matrices and silicone rubber at frequencies above and below the resonant frequency. The results reported suggest that measurement of the modulus at the resonant frequency of a viscoelastic material provides a good estimate of the elastic modulus while measurements below and above the resonant frequency contain a larger viscous contribution ...

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    2. An overview of methods to mitigate artifacts in optical coherence tomography imaging of the skin

      An overview of methods to mitigate artifacts in optical coherence tomography imaging of the skin

      Background Optical coherence tomography (OCT) of skin delivers three-dimensional images of tissue microstructures. Although OCT imaging offers a promising high-resolution modality, OCT images suffer from some artifacts that lead to misinterpretation of tissue structures. Therefore, an overview of methods to mitigate artifacts in OCT imaging of the skin is of paramount importance. Speckle, intensity decay, and blurring are three major artifacts in OCT images. Speckle is due to the low coherent light source used in the configuration of OCT. Intensity decay is a deterioration of light with respect to depth, and blurring is the consequence of deficiencies of optical components ...

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    3. Laser Scanner Detects Skin Cancer in Less Than 30 Seconds

      Laser Scanner Detects Skin Cancer in Less Than 30 Seconds

      Current skin cancer diagnosis can last a number of weeks and be very upsetting. However, a new imaging system developed by a group of European scientists could dramatically speed up the process and reduce the need for debilitating sentinel-lymph node biopsies by placing real-time cancer diagnosis in the hands of a dermatologist. Multiple stages of skin cancer diagnosis can involve visiting a GP, being sent to a dermatologist for a skin biopsy, waiting for laboratory analysis, having a sentinel lymph node biopsy under general anaesthetic, and then having more tests if the cancer has spread. Now, using a handheld laser ...

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    4. Sciton Announces Collaboration with Michelson Diagnostics Ltd. to Develop OCT Image-Guided Laser Applications

      Sciton Announces Collaboration with Michelson Diagnostics Ltd. to Develop OCT Image-Guided Laser Applications

      Sciton®, a leading manufacturer of high-quality laser and light systems in the aesthetic and medical market, announced its strategic partnership with Michelson Diagnostics Ltd. (MDL), a United Kingdom based company, to offer new levels of personalized skin diagnosis and treatments. "Optical Coherence Tomography (OCT) is a marvelous diagnostic imaging technology," says Jon Holmes , CEO of MDL. "It sees into skin deeper than one millimeter with a resolution of less than 10 microns. Skin sub-layers, sub-structures and morphology, as well as capillary blood flows are accurately recognized for decision making. We are excited that our FDA-approved VivoSight OCT system partners with ...

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    5. Development of a combined OCT-Raman probe for the prospective in vivo clinical melanoma skin cancer screening

      Development of a combined OCT-Raman probe for the prospective in vivo clinical melanoma skin cancer screening

      A combined optical coherence tomography (OCT)-Raman probe was designed and built into a spectral domain OCT head, and its performance was evaluated and compared to the most common Raman probe setups, based on a fiber bundle and confocal free space optics. Due to the use of the full field of view of an OCT scanning lens, the combined probe has a superior performance within maximum permissible exposure limits, compared to the other two probes. Skin Raman spectra, recorded in vivo , further prove the feasibility of the OCT-Raman probe for the future in vivo clinical applications in skin cancer screening.

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    6. Optical Coherence Tomography in Dermatology

      Optical Coherence Tomography in Dermatology

      Optical coherence tomography (OCT), an emerging noninvasive imaging modality, recently received category III Current Procedural Terminology (CPT) codes from the American Medical Association, enabling tracking of its use in the medical community. In this article, we review OCT imaging and its variant systems, discussing its applications and limitations for clinical use. Future directions of OCT technology and goals for obtaining category I CPT codes and reimbursement also are discussed.

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    7. The Future of Boston’s Medical Device Community May Include a Decidedly French Accent

      The Future of Boston’s Medical Device Community May Include a Decidedly French Accent

      For two early stage French medical device companies, the upcoming MassMedic MedTech Showcase could be a game changer. The more than 300 event attendees, including investors and potential business partners, could be a determining factor on whether either company gets an opportunity to become part of the region’s coveted healthcare community. The two French start-ups – DAMAE Medical and Neurallys – are being awarded by the City of Boston and the Greater Boston Chamber of Commerce the “Paris Boston MedTech Award” as recognition of their innovation and their potential for entry into the US market. They were selected by a bi-national ...

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      Mentions: Damae Medical
    8. Optical coherence tomography: An efficient imaging method for the visualization of human epidermis orientation

      Optical coherence tomography: An efficient imaging method for the visualization of human epidermis orientation

      Recently, it has been shown that epidermal sheets taken from suction blisters are very appropriate skin samples for Multi-Photon (MP) microscopy. However, we observed that image quality was much better when the sample was visualized through the basale side. Thus, the epidermis orientation needs to be controlled before MP imaging. We observed that the use of standard laboratory binoculars led to a high rate of false results. In this context, we showed that optical coherence tomography provided clear images of the epidermis orientation without loss of sample integrity and thus represents an effective technique before slide sealing and MP analysis.

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    9. Optical coherence tomography for margin definition of basal cell carcinoma before micrographic surgery—recommendations regarding the marking and scanning technique

      Optical coherence tomography for margin definition of basal cell carcinoma before micrographic surgery—recommendations regarding the marking and scanning technique

      Background/purpose Mohs Micrographic Surgery (MMS) is the preferred therapeutic treatment for high-risk basal cell carcinoma (BCC). Optical Coherence Tomography (OCT) is a non-invasive imaging technique that enables the diagnosis of BCC. We thought to determine the margins of BCCs with OCT, prior to MMS, to reduce the number of surgical steps. Methods Different permanent markers were tested on the skin regarding line width, resistance against disinfection and brightness in the OCT image. The visible tumor margins of BCCs were defined by dermoscopy, adding a safety margin of 2 mm and labeled using the selected pen, causing a signal shadow ...

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    10. Investigating the healing mechanisms of an angiogenesis-promoting topical treatment for diabetic wounds using multimodal microscopy

      Investigating the healing mechanisms of an angiogenesis-promoting topical treatment for diabetic wounds using multimodal microscopy

      Impaired skin wound healing is a significant co-morbid condition of diabetes that is caused by poor microcirculation, among other factors. Studies have shown that angiogenesis, a critical step in the wound healing process in diabetic wounds, can be promoted under hypoxia. In this study, an angiogenesis-promoting topical treatment for diabetic wounds, which promotes angiogenesis by mimicking a hypoxic environment via inhibition of prolyl hydroxylase resulting in elevation or maintenance of hypoxia inducible factor (HIF), was investigated utilizing a custom-built multimodal microscopy system equipped with phase-variance optical coherence tomography (PV-OCT) and fluorescence lifetime imaging microscopy (FLIM). PV-OCT was used to track ...

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    11. Massachusetts General Hospital Receives NIH Grant Quantitative Imaging of Collagen Morphology in Human Scars.

      Massachusetts General Hospital Receives NIH Grant Quantitative Imaging of Collagen Morphology in Human Scars.

      Massachusetts General Hospital Receives a 2017 NIH Grant for $50,000 Quantitative Imaging of Collagen Morphology in Human Scars. The principal investigator is Martin Villiger. The program began in 2017 and ends in 2019. Below is a summary of the proposed work. The overall goal of the proposed research is to develop and validate high-resolution birefringence imaging. The intrinsic birefringence of collagen offers an attractive contrast mechanism to investigate the collagen morphology in human skin and scars. Non-invasive characterization of the collagen organization in scar tissue would facilitate clinical trials that investigate novel therapeutic approaches to reduce scarring by providing ...

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    12. Optical coherence tomography for the investigation of frontal fibrosing alopecia

      Optical coherence tomography for the investigation of frontal fibrosing alopecia

      Background FFA is a cicatricial alopecia that affects the frontotemporal hairline, eyebrows, and body hair. OCT is a non-invasive imaging technique useful in understanding skin architecture and vascularization. Objective To describe structural and vascular findings in FFA using OCT. Methods This was a case-control study conducted from the months of December 2016-February 2017. The study was IRB approved and conducted at the University of Miami Hospital outpatient dermatology hair and nail clinic in Miami, FL. Four patients with biopsy proven FFA, and three healthy age and sex-matched controls participated. OCT scans were taken on cicatricial alopecic band, inflammatory hairline, eyebrow ...

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    13. Optical Coherence Tomography Reveals Mechanobiologically Stable Self-Organizing Di-Fork Architecture of Mice Cutaneous Scars

      Optical Coherence Tomography Reveals Mechanobiologically Stable Self-Organizing Di-Fork Architecture of Mice Cutaneous Scars

      Scientific studies report crucial impacts of biomechanical effectors to modulate wound healing either by scarring or regeneration. Further, the biological decision to predominantly favor the former is still cryptic. Real-time visualization of biomechanical manifestations in situ in scarring is hence necessary. Endorsed by nanostructural testing, synthetic phantom analysis, and computational simulations, we found strong mechanobiological correlates for Swept Source Optical Coherence Tomography (SS-OCT) speckles in mice cutaneous repair (full-thickness) up to 10 months. The theoretical basis of the optomechanics to provide insights into scar form-factor and evolution is proposed. Optomechanical changes have been considered as the resultant of intrinsic (e ...

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    14. Three-dimensional optical coherence tomography apparatus and its application

      Three-dimensional optical coherence tomography apparatus and its application

      Provided herein are devices and systems that apply full-field optical coherence tomography (OCT) technology to three-dimensional skin tissue imaging. A special designed Mirau type objective and an optical microscope module allowing both OCT mode and orthogonal polarization spectral imaging (OPSI) mode are disclosed.

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    15. In vivo characterization of structural changes after topical application of glucocorticoids in healthy human skin

      In vivo characterization of structural changes after topical application of glucocorticoids in healthy human skin

      Topical glucocorticoids (GC) are known to induce changes in human skin with the potential to develop skin atrophy. Here, atrophogenic effects and subsequent structural changes in the skin after topical application of GC were investigated in vivo . Sixteen healthy volunteers were topically treated daily on the forearms with clobetasol propionate, betamethasone dipropionate, and the petrolatum vehicle for 4 weeks. All treated skin areas and a nontreated control area were examined by ultrasound, optical coherence tomography, confocal laser scanning microscopy, multiphoton tomography (MPT), and resonance Raman spectroscopy at baseline 1 day after last application and 1 week after last application. Investigated ...

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      Mentions: Jürgen Lademann
    16. Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines

      Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines

      Background Dynamic optical coherence tomography (D-OCT) has recently been introduced in dermatology. In contrast to ‚Standard’ OCT imaging, which exclusively relies on the morphological analysis of the tissue, D-OCT allows the in-vivo visualisation of blood flow. Preliminary D-OCT data showed differences in the vascularisation of nevus to melanoma transition, suggesting that this technology may help to differentiate between benign and malignant lesions. Objective Several factors may influence the quality of D-OCT imaging. Therefore, standard operating procedures as well as a common terminology are required for better validation and comparison of the images. Methods Here we present practical guidelines for optimal ...

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    17. In vivo measurements of blood vessels’ distribution in non-melanoma skin cancer by dynamic optical coherence tomography — a new quantitative measure?

      In vivo measurements of blood vessels’ distribution in non-melanoma skin cancer by dynamic optical coherence tomography — a new quantitative measure?

      Background Skin biopsies only provide point-in-time data making longitudinal studies difficult. Using Dynamic optical coherence tomography (D-OCT) in vivo , non-invasive imaging of the microvasculature becomes possible. The current OCT literature is almost exclusively based on qualitative information but quantitative data may offer additional advantages, for example, by reducing observer variation. The objective of this study was to evaluate the in vivo superficial distribution of blood vessels, defined as the surface-to-first-vessel distance, in actinic keratosis, basal cell carcinoma, squamous cell carcinoma and normal skin. Methods D-OCT images of 52 histologically verified lesions and corresponding normal skin were included. The dataset consisted ...

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    18. System and method for fingerprint validation

      System and method for fingerprint validation

      The invention provides a system and method for rapid validation of identity from tissue using registered two dimensional and optical coherence tomography (OCT) scan images. The preferred embodiment provides, for a human fingerprint, validation that the surface fingerprint matches the primary fingerprint. An alternate embodiment provides validation of "aliveness" by ascertaining blood flow. Various embodiments are taught.

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    19. New Non-invasive Techniques to Quantify Skin Surface Strain and Sub-surface Layer Deformation of Finger-pad during Sliding

      New Non-invasive Techniques to Quantify Skin Surface Strain and Sub-surface Layer Deformation of Finger-pad during Sliding

      tudies on the variation of skin properties with gender, age and anatomical region, with regards to interaction with different materials have resulted in significant research output. Investigations on skin surface strain and sub-surface layer deformation during sliding, however, have not received as much attention. This novel study uses two non-invasive techniques, optical coherence tomography (OCT) and digital image correlation (DIC), to measure properties of the index finger of a 25 year old female when under normal and shear loading. Measurements were taken during static, and for the first time, dynamic phases. It was observed that the number of ridges in ...

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    20. Michelson Diagnostics Secures CPT codes for Optical Coherence Tomography Imaging of Skin

      Michelson Diagnostics Secures CPT codes for Optical Coherence Tomography Imaging of Skin

      Michelson Diagnostics announces that the American Medical Association (AMA) CPT Editorial Panel recently approved two new Category III CPT codes for Optical Coherence Tomography (OCT) imaging of skin. Code 0470T is for OCT microstructural and morphological imaging of skin, image acquisition, interpretation and report for a first lesion; code 0471T is the same for each additional lesion. The new Category III codes, which are for emerging technologies, services, and procedures, are effective July 1, 2017. Michelson Diagnostics pursued approval of this code at the AMA CPT Panel meeting in October 2017, receiving support from the American Academy of Dermatology. “Obtaining ...

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    1-24 of 738 1 2 3 4 ... 29 30 31 »
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