1. Articles in category: Dermatology

    1-24 of 515 1 2 3 4 ... 20 21 22 »
    1. Vertically Integrated Array-type Mirau-based Oct System for early detection of skin pathologies

      Vertically Integrated Array-type Mirau-based Oct System for early detection of skin pathologies

      VIAMOS proposes an OCT microsystem able to revolutionize the field of microscopes for dermatology imaging. The aim of the project is to develop a new generation of Optical Coherence Tomography micro-system in order to help the diagnosis of skin pathologies thanks to a three dimensional image. The challenge is to provide a hand-held, low-cost and fully parallel spectral domain OCT micro-device. The consequence is a significant upgrade by adding new features such as heterodyne detection and integrated swept source. The project leans on the experience of 8 highly recognized European research institutes and companies such as the FEMTO-ST, University of ...

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    2. Advances in non-invasive techniques as aids to the diagnosis and monitoring of therapeutic response in plaque psoriasis: a review

      Advances in non-invasive techniques as aids to the diagnosis and monitoring of therapeutic response in plaque psoriasis: a review

      Plaque psoriasis is a common, chronic, inflammatory disease with a multifactorial etiopathogenesis. Although its diagnosis is often based on clinical features, in ambiguous cases a biopsy with histopathologic confirmation may be necessary. Advanced high-definition imaging techniques may be useful in the study of skin properties in vivo and may facilitate therapeutic monitoring. Available imaging tools vary in their resolution, depth of penetration and visual representation (horizontal, vertical, three-dimensional), and in the type of skin structures visualized. The purpose of this review is to analyze a variety of non-invasive techniques that may assist in establishing definitive diagnoses, as well as in ...

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    3. Improvement of Transdermal Delivery of Sumatriptan Succinate Using a Novel Self-dissolving Microneedle Array Fabricated from Sodium Hyaluronate in Rats

      Improvement of Transdermal Delivery of Sumatriptan Succinate Using a Novel Self-dissolving Microneedle Array Fabricated from Sodium Hyaluronate in Rats

      The purpose of the present study was to develop an alternative transdermal formulation containing sumatriptan succinate (SS) for the treatment of migraine. Novel self-dissolving SS-loaded microneedle arrays (MNs) were fabricated from sodium hyaluronate and their efficacy for transdermal delivery of SS was characterized. The resulting MNs maintained their skin piercing abilities for at least 30 min after being placed at a high relative humidity of 75%. Rapid release of SS from the MNs was also observed in vitro . Optical coherence tomography images demonstrated that MNs were able to successfully pierce into rat skin without any bending or cracking, and needles ...

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    4. Non-invasive diagnosis of sweat gland dysplasia using optical coherence tomography and reflectance confocal microscopy in a family with anhidrotic ectodermal dysplasia (Christ-Siemens-Touraine syndrome

      Non-invasive diagnosis of sweat gland dysplasia using optical coherence tomography and reflectance confocal microscopy in a family with anhidrotic ectodermal dysplasia (Christ-Siemens-Touraine syndrome

      Background Anhidrotic ectodermal dysplasia (AED) is an inherited syndrome, which originates mainly from genetic alteration of the ectodysplasin A (EDA) gene. It regularly affects the adnexa of the skin which results in a characteristic phenotype of the patients including hypo- or anhidrosis leading to severe disturbances in the regulation of body temperature. Objectives To prevent the development of the symptoms in early childhood promising therapeutic approaches are currently under clinical investigation. In this context, timely diagnosis of this genetic syndrome is crucial. The purpose of our study was the investigation of modern non-invasive imaging methods such as optical coherence tomography ...

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    5. In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography Diagnosis, Pathogenesis, and Treatment

      In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography Diagnosis, Pathogenesis, and Treatment

      Miliaria profunda (MP) is a condition of sweat duct obstruction manifesting with generalized papular eruption and anhidrosis. 1 , 2 Using imaging with high-definition optical coherence tomography (HD-OCT), we identified, in vivo, the depth of lesions in MP and the likely location of sweat duct obstruction. To our knowledge, this is the first time such an evaluation has been performed.

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    6. Precise measurement of volume of eccrine sweat gland in mental sweating by optical coherence tomography

      Precise measurement of volume of eccrine sweat gland in mental sweating by optical coherence tomography

      We have demonstrated dynamic analysis of the physiological function of eccrine sweat glands underneath skin surface by optical coherence tomography (OCT). In this paper, we propose a method for extraction of the specific eccrine sweat gland by means of the connected component extraction process and the adaptive threshold method, where the en face OCT images are constructed by the swept-source OCT. In the experiment, we demonstrate precise measurement of the volume of the sweat gland in response to the external stimulus.

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    7. Morphology of human sweat ducts observed by optical coherence tomography and their frequency of resonance in the terahertz frequency region : Scientific Reports : Nature Publishing Group

      Morphology of human sweat ducts observed by optical coherence tomography and their frequency of resonance in the terahertz frequency region : Scientific Reports : Nature Publishing Group

      It is crucial to understand the various biological effects induced by terahertz (THz) electromagnetic waves with the rapid development of electronic and photonic devices operating in the THz frequency region. The presence of sweat glands plays an important role in THz wave interactions with human skin. We investigated the morphological features of sweat ducts using optical coherence tomography (OCT) to further understand such phenomena. We observed remarkable features of the ducts, such as their clear helical structure. The intersubject and intrasubject variations in the diameter of sweat ducts were considerably smaller than the variations in other structural parameters, such as ...

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    8. Quantitative and rapid estimations of human sub-surface skin mass using ultra-high-resolution spectral domain optical coherence tomography

      Quantitative and rapid estimations of human sub-surface skin mass using ultra-high-resolution spectral domain optical coherence tomography

      In vivo optical coherence tomography (OCT) image of angioma (A). Thin red arrows point to a blood vessel (BV). Non-invasive and quantitative estimations for the delineation of sub-surface tumor margins could greatly aid in the early detection and monitoring of the morphological appearances of tumor growth, ensure complete tumor excision without the unnecessary sacrifice of healthy tissue, and facilitate post-operative follow-up for recurrence. In this study, a high-speed, non-invasive, and ultra-high-resolution spectral domain optical coherence tomography (UHR-SDOCT) imaging platform was developed for the quantitative measurement of human sub-surface skin mass. With a proposed robust, semi-automatic analysis, the system can rapidly ...

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    9. Optical coherence tomography for planning of follicular unit extraction

      Optical coherence tomography for planning of follicular unit extraction

      BACKGROUND: As the subcutaneous course of the hair follicle cannot be extrapolated from the angle of hair emergence, the follicular unit extraction (FUE) method bears the risk of follicle transsection potentially affecting the success of the whole intervention. Histological examination can provide this angle information but are too time consuming and invasive to be integrated in the workflow. OBJECTIVE: In this work, the authors present an effective and noninvasive way to determine these subcutaneous follicle angles. METHODS AND MATERIALS: For this purpose, the authors use optical coherence tomography to provide images of the first 2 to 3 mm of the ...

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    10. High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography

      High resolution imaging of acne lesion development and scarring in human facial skin using OCT-based microangiography

      Background and Objective Acne is a common skin disease that often leads to scarring. Collagen and other tissue damage from the inflammation of acne give rise to permanent skin texture and microvascular changes. In this study, we demonstrate the capabilities of optical coherence tomography-based microangiography in detecting high-resolution, three-dimensional structural, and microvascular features of in vivo human facial skin during acne lesion initiation and scar development. Materials and Methods A real time swept source optical coherence tomography system is used in this study to acquire volumetric images of human skin. The system operates on a central wavelength of 1,310 ...

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    11. In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea

      In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea

      Optical coherence tomography (OCT) is a noninvasive imaging technique that allows real-time high-definition cross-sectional visualization of tissues. Conventional OCT was introduced in dermatology in 1997 and has shown benefit in evaluating malignant neoplasms and inflammatory skin disorders. 1 , 2 High-definition OCT (HD-OCT) scanners have recently been developed; they provide a higher resolution than conventional OCT and horizontal, in additional to vertical, sectional imaging, which conventional OCT does not provide.

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    12. High-definition optical coherence tomography algorithm for discrimination of basal cell carcinoma from clinical BCC imitators and differentiation between common subtypes

      High-definition optical coherence tomography algorithm for discrimination of basal cell carcinoma from clinical BCC imitators and differentiation between common subtypes

      Background Preliminary studies have described morphological features of basal cell carcinoma (BCC) imaged by high-definition optical coherence tomography (HD-OCT) and suggested that this technique may aid in its diagnosis and management. However, systematic studies evaluating the accuracy of HD-OCT for the diagnosis of BCC are lacking. Objective The aim of this study was to identify three-dimensional (3-D) HD-OCT features able i) to distinguish BCC from clinical BCC imitators and ii) to discriminate between the most common BCC subtypes. Based on these particular features, a diagnostic algorithm will be suggested. Method A total of 50 histopathologically confirmed BCCs (18 superficial, 19 ...

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    13. VivoSightOCT Education Centre

      VivoSightOCT Education Centre

      Welcome to the VivoSight OCT Education Centre website This is an open access facility providing information about the use of Optical Coherence Tomography in Dermatology. Please feel free to browse using the navigation guides, We hope you will find the site useful. If you would like to contribute images or just give us some feedback please contact us on info@vivosightatlas.com

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    14. Recellularising of human acellular dermal matrices imaged by high-definition optical coherence tomography

      Recellularising of human acellular dermal matrices imaged by high-definition optical coherence tomography

      Background High-definition optical coherence tomography (HD-OCT) permits real-time 3-D imaging of the impact of selected agents on human skin allografts. Objective The real-time 3-D HD-OCT assessment of i) the impact on morphological and cellular characteristics of the processing of human acellular dermal matrices (HADMs) and ii) repopulation of HADMs in vitro by human fibroblasts and remodelling of the extracellular matrix by these cells. Method Four different skin decellularisation methods, Dispase II/Triton X-100, Dispase II/SDS (sodium dodecyl sulphate), NaCl/Triton X-100 and NaCl/SDS, were analyzed by HD-OCT. HD-OCT features of epidermal removal, dermo-epidermal junction (DEJ) integrity, cellularity and ...

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    15. OCT firm Michelson Diagnostics closes £2.5m 'Series B' funding

      OCT firm Michelson Diagnostics closes £2.5m 'Series B' funding

      Michelson Diagnostics , the UK-based medical device company focused on multi-beam Optical Coherence Tomography technology, has closed the £2.5m first tranche of its “Series B” financing, led by strategic investor and medical specialist Smith & Nephew alongside new investor Kent County Council as well as existing investors. The £2.5m investment will be used to expand Michelson Diagnostics’ commercial presence in Germany; launch the Company’s next generation VivoSight OCT tissue-imaging system; complete the ongoing US multi-center clinical biopsy avoidance study; and explore further applications in wound care and dentistry. VivoSight is a point-of-care tissue-imaging system that for the first time ...

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    16. A review of state-of-the-art speckle reduction techniques for optical coherence tomography fingertip scans

      A review of state-of-the-art speckle reduction techniques for optical coherence tomography fingertip scans

      Standard surface fingerprint scanners are vulnerable to counterfeiting attacks and also failure due to skin damage and distortion. Thus a high security and damage resistant means of fingerprint acquisition is needed, providing scope for new approaches and technologies. Optical Coherence Tomography (OCT) is a high resolution imaging technology that can be used to image the human fingertip and allow for the extraction of a subsurface fingerprint. Being robust toward spoofing and damage, the subsurface fingerprint is an attractive solution. However, the nature of the OCT scanning process induces speckle: a correlative and multiplicative noise. Six speckle reducing filters for the ...

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    17. Michelson Diagnostics closes £2.5 million First Tranche of £4.0 million Series B fundraising Smith & Nephew as Cornerstone Investor

      Michelson Diagnostics closes £2.5 million First Tranche of £4.0 million Series B fundraising Smith & Nephew as Cornerstone Investor

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, is pleased to announce that it has closed the £2.5 million First Tranche of its Series B financing. This was led by strategic investor, global medical technology business Smith & Nephew and included new investor Kent County Council as well as existing investors. The £2.5 million investment will be used to expand the Michelson Diagnostics’ commercial presence in Germany; launch the Company’s next generation VivoSight OCT tissue-imaging system; complete the ongoing US multi-centre clinical biopsy avoidance study and explore further applications of ...

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    18. Smith & Nephew bets on technology that 'sees through the skin'

      Smith & Nephew bets on technology that 'sees through the skin'

      Smith & Nephew has bet on a new technology that enables doctors to "see through the skin", in the hope that it could be used by the company's growing wound care business. The med tech giant has invested £1.25m in Michelson Diagnostics, a small Kent-based business which uses laser beams to produce high resolution images of cells beneath the surface of the skin. Michelson's Vivosight system is already being used in place of biopsies to diagnose non-melanoma skin cancer , a less aggressive but more common variety of the disease compared with more deadly melanoma skin cancers. But the ...

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    19. Comparative analysis of combined spectral and optical tomography methods for detection of skin and lung cancers

      Comparative analysis of combined spectral and optical tomography methods for detection of skin and lung cancers

      Malignant skin tumors of different types were studied in vivo using optical coherence tomography (OCT), backscattering (BS), and Raman spectroscopy (RS). A multimodal method is proposed for early cancer detection based on complex analysis of OCT images by their relative alteration of scattered-radiation spectral intensities between malignant and healthy tissues. An increase in average accuracy of diagnosis was observed for a variety of cancer types (9% sensitivity, 8% specificity) by a multimodal RS-BS-OCT system in comparison with any of the three methods used separately. The proposed approach equalizes the processing rates for all methods and allows for simultaneous imaging and ...

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      Mentions: Pavel Zakharov
    20. High-definition optical coherence tomography algorithm for the discrimination of actinic keratosis from normal skin and from squamous cell carcinoma

      High-definition optical coherence tomography algorithm for the discrimination of actinic keratosis from normal skin and from squamous cell carcinoma

      Background Preliminary studies described morphological features of actinic keratosis (AK) and squamous cell carcinoma (SCC) imaged by High-Definition Optical Coherence Tomography (HD-OCT) and suggested that this technique may aid in their diagnosis. However, systematic studies evaluating the accuracy of HD-OCT for the diagnosis of AK and SCC are lacking so far. Objective In this study, we sought to design an algorithm for AK classification that could (i) distinguish SCC from AK and normal skin, (ii) differentiate AK from normal skin and (iii) discriminate AKs with adnexal involvement from those without. Methods A total of 53 histopathologically confirmed lesions (37 AKs ...

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    21. Assessment of a scoring system for Basal Cell Carcinoma with multi-beam optical coherence tomography

      Assessment of a scoring system for Basal Cell Carcinoma with multi-beam optical coherence tomography

      Background Multi-beam optical coherence tomography (OCT) is a novel method of non-invasive skin imaging allowing the evaluation of tissue at high level of lateral and axial resolution. It permits the horizontal and vertical evaluation of the extent of diseases. Objective Herein, we aimed to validate diagnosing basal cell carcinoma (BCC) by OCT using a newly developed scoring system (‘Berlin Score’-BS). This was based on the predetermined criteria such as dark border underneath the tumour and ovoid structures. Their frequency and distribution in subtypes of BCC were evaluated. Methods The study was conducted in two phases, in which the experience ...

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    1-24 of 515 1 2 3 4 ... 20 21 22 »
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