1. Articles in category: Dermatology

    1-24 of 933 1 2 3 4 ... 37 38 39 »
    1. Toward clinical elastography of dermal tissues: A medical device to probe skin’s elasticity through suction, with subsurface imaging via optical coherence tomography

      Toward clinical elastography of dermal tissues: A medical device to probe skin’s elasticity through suction, with subsurface imaging via optical coherence tomography

      ABSTRACT The mechanical behavior of dermal tissues is unarguably recognized for its diagnostic ability and in the last decades received a steadily increasing interest in dermatology practices. Among the various methods to investigate the mechanics of skin in clinical environments, suction-based ones are especially noteworthy, thanks to their qualities of minimal invasiveness and relative simplicity of setups and data analysis. In such experiments, structural visualization of the sample is highly desirable, both in its own right and because it enables elastography. The latter is a technique that combines the knowledge of an applied mechanical stimulus and the visualization of the ...

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    2. Technology in Practical Dermatology (Textbook)

      Technology in Practical Dermatology (Textbook)

      This book provides a complete overview on the latest available technologies in dermatology, while discussing future trends of this ever-growing field. This handy guide provides clinicians and researchers with a clear understanding of the advantages and challenges of laser and imaging technologies in skin medicine today. It also includes a section on imaging techniques for the evaluation of skin tumors, with chapters devoted to dermoscopy, in vivo and ex vivo reflectance confocal microscopy, high frequency ultrasound, optical coherence tomography, and a closing part on latest approaches to wound management. Completed by over 200 clinical images, Current Technology in Practical Dermatology ...

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    3. Towards quantitative assessment of burn based on photoacoustic and optical coherence tomography

      Towards quantitative assessment of burn based on photoacoustic and optical coherence tomography

      Accurate and timely assessment of the severity of burn is essential for the treatment of burns. Currently, although most first‐degree and third‐degree burns are easily diagnosed through visual inspection or auxiliary diagnostic methods, the second‐degree burn is still difficult to distinguish due to the ambiguity boundaries of second‐degree with first‐degree and third‐degree burns. In this study, we proposed a non‐invasive technique by combing photoacoustic imaging (PAI) and optical coherence tomography (OCT) to multi‐parameter quantitatively assess the burns. The feasibility and capacity of the dual‐mode PAT/OCT for assessing the burns was ...

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    4. Automatic Segmentation of Epidermis and Hair Follicles in Optical Coherence Tomography Images of Normal Skin by Convolutional Neural Networks

      Automatic Segmentation of Epidermis and Hair Follicles in Optical Coherence Tomography Images of Normal Skin by Convolutional Neural Networks

      Optical coherence tomography (OCT) is a well-established bedside imaging modality that allows analysis of skin structures in a non-invasive way. Automated OCT analysis of skin layers is of great relevance to study dermatological diseases. In this paper, an approach to detect the epidermal layer along with the follicular structures in healthy human OCT images is presented. To the best of the authors' knowledge, the approach presented in this paper is the only epidermis detection algorithm that segments the pilosebaceous unit, which is of importance in the progression of several skin disorders such as folliculitis, acne, lupus erythematosus, and basal cell ...

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      Mentions: Mette Mogensen
    5. Dynamic Optical Coherence Tomography Imaging of Telangiectasia Prior to Intense Pulsed Light Treatment—An Opportunity to Target Treatment?

      Dynamic Optical Coherence Tomography Imaging of Telangiectasia Prior to Intense Pulsed Light Treatment—An Opportunity to Target Treatment?

      Background and Objectives To investigate whether optical coherence tomography (OCT) could be utilized to characterize blood flow and vessel dimensions of facial telangiectasias before and during consecutive intense pulsed light (IPL) treatment. Study Design/Materials and methods Dynamic OCT (D‐OCT) was used to image telangiectasia immediately before and after, 1–3 days after, and 1 month after IPL treatment. Measurements included vessel width and depth, blood flow, and attenuation. Vessel dimensions at baseline were verified by a blinded observer. Clinical improvement was detected as good, moderate, or none, and adverse effects were registered at 1‐month follow‐up. Results ...

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    6. The Application of Non-invasive and Cellular Level Resolution Fullfield Optical Coherence Tomography: Establishment and Analysis of Subcutaneous Cellular Level Image Database of Anatomical Locations in Healthy Volunteers and Evaluation of Usability

      The Application of Non-invasive and Cellular Level Resolution Fullfield Optical Coherence Tomography: Establishment and Analysis of Subcutaneous Cellular Level Image Database of Anatomical Locations in Healthy Volunteers and Evaluation of Usability

      The OCT can provide cellular resolution (~1μm in lateral and axial directions) images. A cellular resolution OCT has the characteristics of non-invasive, non-radioactive, labelfree, real-time and high tissue penetration depth that are highly valuable for clinical use. This technology allows visualization of important structural features such as the epidermis and dermis and the epidermal-dermal junction. OCT has the advantage of generating cross-sectional images, like the orientation of pathology slides. The ApolloVue® S100 Image System is intended to be used as a non-invasive imaging tool in the evaluation of external human skin tissue microstructure by providing two-dimensional, crosssectional (B-scan) and ...

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    7. In vivo Imaging of Sarcoptes scabiei infestation using Line‐field Confocal Optical Coherence Tomography

      In vivo Imaging of Sarcoptes scabiei infestation using Line‐field Confocal Optical Coherence Tomography

      Scabies remains a worldwide spread disease of considerable health and economic burden with repeated outbreaks in community settings.(1) Scabies agent is the ectoparasite Sarcoptes scabiei var. hominis ; this invisible mite causes a progressive rash, which can be misdiagnosed with eczema or pruritus sine materia . Diagnosis is based on characteristic clinical features (intense nightly itch, inflammatory excoriated papules in typical sites) and history of contact to infected patients.

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    8. The MOLES System for Planning Management of Melanocytic Choroidal Tumors: Is It Safe?

      The MOLES System for Planning Management of Melanocytic Choroidal Tumors: Is It Safe?

      Purpose: To evaluate the MOLES system for identifying malignancy in melanocytic choroidal tumors in patients treated for choroidal melanoma. Methods: Records of 615 patients treated for choroidal melanoma between January 2017 and December 2019 were reviewed. Patients were excluded if iris and/or ciliary body involvement (106 patients), inadequate fundus photography (26 patients), no images available for review (21 patients) and/or treatment was not primary (11 patients). Demographic data and AJCC TNM Stage were collected. Color fundus and autofluorescence photographs (FAF), optical coherence tomography (OCT) and B-scan ultrasounds were prospectively reviewed. MOLES scores were assigned according to five criteria ...

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    9. Towards Indicating Human Skin State In Vivo Using Geometry-Dependent Spectroscopic Contrast Imaging

      Towards Indicating Human Skin State In Vivo Using Geometry-Dependent Spectroscopic Contrast Imaging

      Skin plays a significant role in human body function and its collagen states change during the human skin ageing process, which affects skin function. We previously reported on geometry-dependent spectroscopic contrast achieved by spectroscopic micro-optical coherence tomography ( S μ OCT), which discovered that transversely oriented and regularly arranged nano-cylinders selectively backscatter the long-wavelength lights and generate spectral centroid (SC) shifts towards the long wavelengths within a spectral window of 700 − 950 nm . Here we further proposed a novel method towards indicating the state of human skin in vivo using geometry-dependent spectroscopic contrast imaging. The proposed method can obtain spectroscopic contrast images ...

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    10. Synchronous fingerprint acquisition system based on total internal reflection and optical coherence tomography

      Synchronous fingerprint acquisition system based on total internal reflection and optical coherence tomography

      he research of external fingerprint collected by total internal reflection (TIR) has been carried out for decades and research of internal fingerprint of optical coherence tomography (OCT) has just begun. The internal fingerprint can be hardly affected by the finger surface status, due to its strong anti-interference and anti-spoofing ability, which can serve as a powerful supplement to external fingerprint. However, matching fingerprints acquired by different ways can lead to a drop in fingerprint recognition accuracy owing to the differences in fingerprint quality, distortions and detection areas. Whether the internal fingerprint can be used to replace the external fingerprint for ...

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    11. Integrated effects of fractional laser microablation and sonophoresis on skin immersion optical clearing in vivo

      Integrated effects of fractional laser microablation and sonophoresis on skin immersion optical clearing in vivo

      This study is aimed to find an approach for effective skin optical clearing in vivo using polyethylene glycol 300 (PEG‐300) as an optical clearing agent in combination with physical enhancers: fractional laser microablation (FLMA), and/or low‐frequency sonophoresis. In this study albino outbred rats were used. Light attenuation coefficient and optical clearing potential of these approaches were evaluated in upper (from ~70 to ~200 μm) and middle (from ~200 to ~400 μm) dermis separately using optical coherence tomography (OCT). In 30 min, optical clearing potential of sonophoresis in combination with FLMA and PEG‐300 in the upper dermis ...

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      Mentions: Valery V. Tuchin
    12. Synthetic Retinoid Seletinoid G Improves Skin Barrier Function through Wound Healing and Collagen Realignment in Human Skin Equivalents

      Synthetic Retinoid Seletinoid G Improves Skin Barrier Function through Wound Healing and Collagen Realignment in Human Skin Equivalents

      The outer epidermal skin is a primary barrier that protects the body from extrinsic factors, such as ultraviolet (UV) radiation, chemicals and pollutants. The complete epithelialization of a wound by keratinocytes is essential for restoring the barrier function of the skin. However, age-related alterations predispose the elderly to impaired wound healing. Therefore, wound-healing efficacy could be also considered as a potent function of an anti-aging reagent. Here, we examine the epidermal wound-healing efficacy of the fourth-generation retinoid, seletinoid G, using HaCaT keratinocytes and skin tissues. We found that seletinoid G promoted the proliferation and migration of keratinocytes in scratch assays ...

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    13. Characterization of early-stage cutaneous radiation injury by using optical coherence tomography angiography

      Characterization of early-stage cutaneous radiation injury by using optical coherence tomography angiography

      Cutaneous radiation injury (CRI) is a skin injury caused by exposure to high dose ionizing radiation (IR). Diagnosis and treatment of CRI is difficult due to its initial clinically latent period and the following inflammatory bursts. Early detection of CRI before clinical symptoms will be helpful for effective treatment, and various optical methods have been applied with limitations. Here we show that optical coherence tomography angiography (OCTA) could detect changes in the skin during the latent period in CRI mouse models non-invasively. CRI was induced on the mouse hindlimb with exposure to various IR doses and the injured skin regions ...

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      Mentions: Ki Hean Kim
    14. Robust and high-security fingerprint recognition system using optical coherence tomography

      Robust and high-security fingerprint recognition system using optical coherence tomography

      Traditional fingerprint recognition systems are vulnerable to attacks, such as the use of artificial fingerprints, and poor performance will be achieved if the captured surface fingerprints are of low-quality. Developing high-security and robust fingerprint recognition systems is of increasing concern in modern society. The introduction of optical coherence tomography (OCT) for fingerprint imaging opens up a new research domain for fingerprint recognition due to its ability to capture the depth information of skin layers. This paper proposes a fingerprint recognition system based on OCT. The research first establishes a database with normal, worn-out, artificial and degraded fingerprints imaged by our ...

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    15. Optical Coherence Tomography in the Evaluation of the Scalp and Hair: Common Features and Clinical Utility

      Optical Coherence Tomography in the Evaluation of the Scalp and Hair: Common Features and Clinical Utility

      Background and Objective Early diagnosis and treatment of hair loss disorders is vital in providing patients with improved psychological outcomes. Non‐invasive imaging with optical coherence tomography (OCT) may be useful in characterizing and managing alopecia. Despite expanding clinical applications of OCT in dermatology, guidelines demonstrating in vivo features of normal and alopecic scalp images remain scant. This pilot study aims to provide an atlas of OCT findings of healthy and alopecia subjects, explore diagnostic quantitative endpoints of alopecia, and compare epidermal thickness and follicular density between scalp regions. Study Design/Materials and Methods A total of 32 patients (19 ...

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      Mentions: UC Irvine
    16. Skin Imaging to Inform Laser Treatments

      Skin Imaging to Inform Laser Treatments

      The purpose of this study is to obtain information (such as lesion depth, depth of the most superficial part of the lesion, and the size and density of blood vessels) with the assistance of an imaging device, and use this information to assist in selection of laser settings for the treatment of skin conditions. The imaging modality is called Optical Coherence Tomography (OCT). Multiple laser modalities will be used, including intense pulsed light (BroadBand Light, Profractional Sciton), pulsed dye laser (Vbeam Perfecta, Candela), long-pulse 755nm (GentleLASE, Candela), Sciton long-pulse 1064nm lasers, and non-ablative and ablative fractional resurfacing (Profractional, Sciton) lasers ...

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      Mentions: UC Irvine
    17. Optical coherence tomography for the investigation of skin adaptation to mechanical stress

      Optical coherence tomography for the investigation of skin adaptation to mechanical stress

      Background Skin breakdown due to limb‐socket interface stress is a significant problem for lower limb prosthesis users. While it is known that skin can adapt to stress to become more resistant to breakdown, little is understood about skin adaptation and few methods exist to noninvasively investigate it. In this study, we present novel, noninvasive imaging methods using Optical Coherence Tomography (OCT) to assess key features of the cutaneous microvasculature that may be involved in skin adaptation. Materials and Methods Eight able‐bodied participants wore a modified below‐knee prosthetic socket for two weeks to stress the skin of their ...

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    18. “Virtual Biopsies” of Normal Skin and Thermal and Chemical Burn Wounds

      “Virtual Biopsies” of Normal Skin and Thermal and Chemical Burn Wounds

      The search for noninvasive methods to image and measure the mechanical properties of skin has been a frequent subject of research for many years. Although suction testing, elastography, and other testing can be noninvasive, these tests fail to yield comparable results to destructive tests such as uniaxial tensile testing. Accordingly, researchers have developed a technique to combine optical coherence tomography with vibrational analysis ( vibrational optical coherence tomography ) to image and analyze the biomechanical properties of tissues noninvasively and nondestructively. The result of this analysis is a “ virtual biopsy ” of skin , along with a physical analysis of the major components of ...

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    19. Cutaneous optical coherence tomography for longitudinal volumetric assessment of intradermal volumes in a mouse model

      Cutaneous optical coherence tomography for longitudinal volumetric assessment of intradermal volumes in a mouse model

      Clinical evaluation of skin lesions requires precise and reproducible technologies for their qualitative and quantitative assessment. In this study, we investigate the applicability of a custom-built dermatologic OCT system for longitudinal assessment of intradermal volumes in a mouse model. The OCT, based on an akinetic swept laser working at 1310 nm was employed for visualization and quantification of intradermal deposits of three different hyaluronic acid-based hydrogel formulations – one commercial and two test substances. Hydrogels were applied in 22 BALB/c mice, and measurements were performed over a six-month time period. All hydrogels increased in volume within the first weeks and ...

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    20. Imaging Technologies and Transdermal Delivery in Skin Disorders (Textbook)

      Imaging Technologies and Transdermal Delivery in Skin Disorders (Textbook)

      Provides the latest information on imaging technologies and transdermal delivery in skin disorders This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work. Imaging Technologies and Transdermal Delivery in Skin Disorders starts by outlining the structural characteristics of skin and skin appendages ...

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    21. Skin Pathology Assessment With Optical Technologies

      Skin Pathology Assessment With Optical Technologies

      The Skin Pathology assessment with Optical Technologies (SPOT) study aims to assess the feasibility of recently developed light-based skin imaging tools such as Optical Coherence Tomography (OCT) for the study of eczema (dermatitis [AD]). Tools such as OCT have enabled us to see beneath the skin surface, allowing us to see changes in our skin which are hidden and impossible to assess by eye, simply by shining harmless light into the skin. The investigators want to understand what these changes represent in the broader context of eczema. To do this, the investigators would like to recruit 60 volunteers who have ...

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    22. Optical Coherence Tomography in Diagnosis of Inflammatory Scalp Disorders

      Optical Coherence Tomography in Diagnosis of Inflammatory Scalp Disorders

      Background The common inflammatory scalp disorders share similar clinical manifestations, and patient work up require invasive, undesirable diagnostic procedures like biopsy to ensure correct diagnosis. Optical coherence tomography (OCT) is a noninvasive high‐resolution imaging modality that has found a valuable tool to assist in the diagnose and evaluation of different skin diseases. Objectives To describe the structural and vascular dynamic OCT (D‐OCT) findings of inflammatory scalp disorders including scalp psoriasis, seborrheic dermatitis and contact dermatitis, and to compare trichoscopy and OCT features. Methods Subjects with diagnosis of seborrheic dermatitis, psoriasis, or contact dermatitis were enrolled in this study ...

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    23. Noninvasive Techniques for Quantification of Contact Dermatitis

      Noninvasive Techniques for Quantification of Contact Dermatitis

      The pathophysiology of contact dermatitis includes specific morphological and physiological changes in the skin as a result of the direct toxic effect of exogenous agents and the subsequent inflammatory cascade. These reactions can be quantified by a variety of noninvasive devices. Classical biophysical methods such as the assessment of transepidermal water loss, stratum corneum hydration, and laser Doppler flowmetry are widely used in the investigation, quantification, and discrimination of irritant and allergic reactions of the skin. Novel in vivo techniques such as in vivo Raman spectroscopy have emerged, and the body of evidence on the skin microstructure is growing. Visualization ...

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