1. Articles in category: Dermatology

    1-24 of 960 1 2 3 4 ... 38 39 40 »

    1. Optical coherence tomography for fast bedside imaging, assessment and monitoring of autoimmune inflammatory skin diseases?

      Explore Wiley Online Library Dermatology
      Optical coherence tomography for fast bedside imaging, assessment and monitoring of autoimmune inflammatory skin diseases?

      Optical coherence tomography (OCT) is a non‐invasive, high‐resolution imaging technique with a growing impact in dermatology. The principle of OCT is comparable to that of sonography, except that it uses infrared laser light instead of ultrasound waves. It has been clinically demonstrated that OCT is suitable for discriminating between different types of non‐melanoma skin cancer at an early stage of disease. Optical coherence tomography generates two‐ or three‐dimensional images of up to 2 mm penetration depth, a field of view of 6 mm × 6 mm, and an acquisition time of seconds. The resolution capability of OCT ...

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      Mentions: University of Lübeck

    2. Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography

      Explore SPIE Digital Library Dermatology
      Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography

      Significance: Pulsatility is a vital characteristic of the cardiovascular system. Characterization of the pulsatility pattern locally in the peripheral microvasculature is currently not readily available and would provide an additional source of information, which may prove important in understanding the pathophysiology of arterial stiffening, vascular ageing, and their linkage with cardiovascular disease development. Aim: We aim to confirm the suitability of speckle decorrelation optical coherence tomography angiography (OCTA) under various noncontact/contact scanning protocols for the visualization of pulsatility patterns in vessel-free tissue and in the microvasculature of peripheral human skin. Results: Results from five healthy subjects show distinct pulsatile ...

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      Mentions: David D. Sampson University of Western Australia Qiang Wang

    3. The potential utility of integrated reflectance confocal microscopy-optical coherence tomography for guiding triage and therapy of basal cell carcinomas

      Explore Journal of Cancer Dermatology
      The potential utility of integrated reflectance confocal microscopy-optical coherence tomography for guiding triage and therapy of basal cell carcinomas

      The increasing rate of incidence and prevalence of basal cell carcinomas (BCCs) worldwide, combined with the morbidity associated with conventional surgical treatment has led to the development and use of alternative minimally invasive non-surgical treatments. Biopsy and pathology are used to guide BCC diagnosis and assess margins and subtypes, which then guide the decision and choice of surgical or non-surgical treatment. However, alternatively, a noninvasive optical approach based on combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) imaging may be used. Optical imaging may be used to guide diagnosis and margin assessment at the bedside, and potentially facilitate ...

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      Mentions: Physical Sciences Incorporated Nicusor Iftimia

    4. University of Texas Health Science Center in Houston ReceivesNIH Grant for Combined Optical Coherence Elastography and Tomography for Assessing Skin Involvement in Systemic Sclerosis

      Explore Optical Coherence Tomography News Dermatology , Funding
      University of Texas Health Science Center in Houston ReceivesNIH Grant for Combined Optical Coherence Elastography and Tomography for Assessing Skin Involvement in Systemic Sclerosis

      University of Texas Health Science Center in Houston Receives a 2020 NIH Grant for $398,791 for Combined Optical Coherence Elastography and Tomography for Assessing Skin Involvement in Systemic Sclerosis. The principal investigator is Shervin Assassi. Below is a summary of the proposed work. Systemic sclerosis (SSc-scleroderma) is an autoimmune disease leading to widespread fibrosis in skin and internal organs. Skin involvement is a prominent source of distress and morbidity in this disease. The modified Rodnan skin score (mRSS) as the current gold standard for assessment of skin thickening has limited accuracy, high inter-observer variability, requires extensive training which have ...

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      Mentions: National Institutes of Health FDA University of Texas Health Science Center

    5. Detecting Mouse Squamous Cell Carcinoma from Submicron FF‐OCT Images by Deep Learning

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      Detecting Mouse Squamous Cell Carcinoma from Submicron FF‐OCT Images by Deep Learning

      The standard medical practice for cancer diagnosis requires histopathology, which is an invasive and time‐consuming procedure. Optical coherence tomography (OCT) is an alternative that is relatively fast, non‐invasive, and able to capture three‐dimensional structures of epithelial tissue. Unlike most previous OCT systems, which cannot capture crucial cellular‐level information for squamous cell carcinoma (SCC) diagnosis, the full‐field OCT (FF‐OCT) technology used in this paper is able to produce images at sub‐micron resolution and thereby facilitates the development of a deep learning algorithm for SCC detection. Experimental results show that the SCC detection algorithm can ...

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      Mentions: National Taiwan University Sheng-Lung Huang

    6. Surface and Internal Fingerprint Reconstruction from Optical Coherence Tomography through Convolutional Neural Network

      Explore IEEE Xplore Dermatology , NDE/NDT , Other Non-Medical
      Surface and Internal Fingerprint Reconstruction from Optical Coherence Tomography through Convolutional Neural Network

      Optical coherence tomography (OCT), as a non-destructive and high-resolution fingerprint acquisition technology, is robust against poor skin conditions and resistant to spoof attacks. It measures fingertip information on and beneath skin as 3D volume data, containing the surface fingerprint, internal fingerprint and sweat glands. Various methods have been proposed to extract internal fingerprints, which ignore the inter-slice dependence and often require manually selected parameters. In this paper, a modified U-Net that combines residual learning, bidirectional convolutional long short-term memory and hybrid dilated convolution (denoted as BCL-U Net) for OCT volume data segmentation and two fingerprint reconstruction approaches are proposed. To ...

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    8. Optical Coherence Tomography Imaging in Systemic Sclerosis

      Explore Home - ClinicalTrials.gov Dermatology , Clinical Trials
      Optical Coherence Tomography Imaging in Systemic Sclerosis

      Systemic sclerosis (SSc) is an autoimmune disorder characterized by early vascular endothelial involvement. SSc is a rare and devastating multi-visceral disease when fibrotic lesions extend to the skin and other tissues (heart, lungs, kidneys). The severity of skin involvement in SSc is correlated with functional prognosis and survival. To date, there is no validated tool for a reliable quantitative assessment of skin fibrosis. Optical coherence tomography (OCT) is an innovative non-invasive skin imaging technique that allows micrometric analysis of the superficial layers of the skin. Previous study showed that OCT could detect the loss of the dermal-epidermal junction in an ...

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    10. Optical coherence tomography: a novel imaging approach to visualize and quantify cutaneous microvascular structure and function in patients with diabetes.

      Explore BMJ Open Diabetes Research & Care Dermatology
      Optical coherence tomography: a novel imaging approach to visualize and quantify cutaneous microvascular structure and function in patients with diabetes.

      Introduction The pathophysiology of microvascular disease is poorly understood, partly due to the lack of tools to directly image microvessels in vivo. Research design and methods In this study, we deployed a novel optical coherence tomography (OCT) technique during local skin heating to assess microvascular structure and function in diabetics with (DFU group, n=13) and without (DNU group, n=10) foot ulceration, and healthy controls (CON group, n=13). OCT images were obtained from the dorsal foot, at baseline (33°C) and 30 min following skin heating. Results At baseline, microvascular density was higher in DFU compared with CON ...

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      Mentions: University of Western Australia

    12. Dual cross-linked honey coupled 3D antimicrobial alginate hydrogels for cutaneous wound healing

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      Dual cross-linked honey coupled 3D antimicrobial alginate hydrogels for cutaneous wound healing

      We report potentiation of healing efficacy of alginate by value addition at its structural level. Dual crosslinked (ionically and covalently) sodium alginate hydrogel coupled with honey (HSAG) brings about an intermediate stiffness in the fabric, confers consistent swelling property and limits erratic degradation of the polymer which ultimately provides conducive milieu to cellular growth and proliferation. In this work honey concentrations in HSAGs are varied from 2% to 10%. FTIR, XRD and nanoindentation studies on the HSAGs exhibited physicochemical integrity. In vitro degradation study provided the crucial finding on 4% HSAG having controlled degradation rate up to 12 days with ...

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    13. In vivo characterisation of healthy human skin with a novel, non‐invasive imaging technique: line‐field confocal optical coherence tomography

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      In vivo characterisation of healthy human skin with a novel, non‐invasive imaging technique: line‐field confocal optical coherence tomography

      Background Line‐field confocal optical coherence tomography (LC‐OCT) is a non‐invasive optical technique recently developed for skin examination in vivo . It provides real‐time, high‐resolution vertical images with an isotropic resolution of ~1 µm and a penetration depth of ~500 µm. Objectives Study goals were to qualitatively/quantitatively characterise healthy skin at different body sites using LC‐OCT. Methods The skin of young healthy volunteers was imaged with a handheld LC‐OCT imaging device. Seven body sites (back of the hand, forehead, cheek, nose, chest, forearm, and back) were investigated. An independent qualitative [cutaneous structures’ description; visibility ...

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      Mentions: Arnaud Dubois

    16. Morphometric Optical Imaging of Microporated Nail Tissue: An Investigation of Intermethod Agreement, Reliability, and Technical Limitations

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      Morphometric Optical Imaging of Microporated Nail Tissue: An Investigation of Intermethod Agreement, Reliability, and Technical Limitations

      Background and Objectives While optical imaging is a useful technique to quantitate morphological differences and treatment effects, comparative investigations of the various techniques are lacking. This study aimed at evaluating intermethod agreement, reliability, and technical limitations of wide‐field microscopy (WFM), reflectance confocal microscopy (RCM), and optical coherence tomography (OCT) for morphometry by assessing fractionally ablated nail tissue. Study Design/Materials and Methods Fifty healthy nail clippings were processed with a fractionated CO 2 ‐laser (20 mJ/microbeam, density 15%), measured with calipers, and imaged using WFM, OCT, and RCM. Images were assessed for nail plate thickness, micropore dimensions, degree ...

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      Mentions: Michelson Diagnostics Jon Holmes University of Copenhagen

    18. Physical Sciences Incorporated Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

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      Physical Sciences Incorporated Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

      Physical Sciences Incorporated Receives a 2020 NIH Grant for $672,2387 for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance. The principal investigator is Nicusor Iftimia. Below is a summary of the proposed work. The primary goal of this research project is to develop and translate to clinical use a novel optical imaging technology based on combined Optical Coherence Tomography (OCT) and Confocal Microscopy (CM) for non- invasive real-time diagnosis of non-melanoma skin cancers (NMSCs), tumor subtyping and margin mapping that will assist physician-patient decision in treatment planning (biopsy vs. no biopsy, surgery vs. non-surgical), as well as ...

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      Mentions: National Institutes of Health Physical Sciences Incorporated Nicusor Iftimia

    19. Delayed Tattoo Reaction From Red Dye With Overlapping Clinicopathological Features: Examination With High-Frequency Ultrasound and Line-Field Optical Coherence Tomography

      Explore Dermatology Practical & Conceptual Dermatology
      Delayed Tattoo Reaction From Red Dye With Overlapping Clinicopathological Features: Examination With High-Frequency Ultrasound and Line-Field Optical Coherence Tomography

      Introduction Delayed tattoo reactions include a wide range of clinical presentations and overlapping forms; thus diagnosis can be challenging. We present a case of a delayed tattoo reaction from red dye. Case Presentation An otherwise healthy 40-year-old man presented with firm elevated plaques that arose 4 months previously, within a multicolored tattoo on the right forearm, 8 months after the execution of the tattoo ( Figure 1A ). The patient claimed minimal and only occasional itching. Polarized dermoscopy (Luminis Visiomed, Caliber) highlighted multiple keratotic plugs within the lesion, limited to the red-dyed areas ( Figure 1 ). Examination with line-field confocal optical coherence tomography ...

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    20. Fred Hutchinson Cancer Research Center Receives NIH Grant for Biologic Correlatives of Chronic GVHD Onset

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      Fred Hutchinson Cancer Research Center Receives NIH Grant for Biologic Correlatives of Chronic GVHD Onset

      Fred Hutchinson Cancer Research Center Receives a 2020 NIH Grant for $112,530 for Biologic Correlatives of Chronic GVHD Onset. The principal investigator is Stephanie Lee. Below is a summary of the proposed work. Allogeneic hematopoietic cell transplantation (HCT) can cure many hematologic cancers and other life- threatening hematologic diseases, but 20-50% of survivors develop chronic graft-versus-host disease (cGVHD), the leading cause of morbidity and mortality in transplant survivors. In cGVHD, the donor's immune cells attack the patient setting up a cascade of events resulting in a pleomorphic multi-organ syndrome reminiscent of autoimmune diseases such as systemic sclerosis, systemic ...

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      Mentions: National Cancer Institute National Institutes of Health

    21. Imaging of in vivo pseudoxanthoma elasticum via multiphoton microscopy and optical coherence tomography

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      Imaging of in vivo pseudoxanthoma elasticum via multiphoton microscopy and optical coherence tomography

      Pseudoxanthoma elasticum (PXE) is an autosomal recessive disorder of abnormal elastic tissue deposition and calcification. 1 PXE primarily affects the elastic fibers in the dermis of the skin, Bruch membrane of the eye, and the media and intima of mid-sized arteries. The skin findings may present as small yellow, orange, or cream-colored papules, resembling plucked-chicken skin or cobblestone. The skin on the neck and skin flexures may be lax and redundant because of the impaired elastic features, causing a degree of psychosocial distress. Histologic changes of the skin consist of fragmented and disorganized elastin fibers in the mid and deep ...

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      Mentions: UC Irvine

    22. Mechano‐vibrational spectroscopy of skin: Are changes in collagen and vascular tissue components early signs of basal cell carcinoma formation?

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      Mechano‐vibrational spectroscopy of skin: Are changes in collagen and vascular tissue components early signs of basal cell carcinoma formation?

      Background The modulus and resonant frequency of cancer cells and extracellular matrix are increased in both basal cell and squamous cell carcinomas, and in addition, the collagen stiffness is increased. The organization of the extracellular matrix surrounding cancer cells is clearly different than the extracellular matrix that is seen in normal skin. Materials and Methods We have used vibrational optical coherence tomography (VOCT) to measure the resonant frequency and stiffness of collagen, vascular, and reorganized fibrous extracellular matrix components. Measurements of vessels and fibrotic collagen content made on basal cell carcinomas (BCCs) are compared to similar measurements made on normal ...

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