1. Articles in category: Dermatology

    1-24 of 1194 1 2 3 4 ... 48 49 50 »
    1. Fiber-based hand-held RCM-OCT probe for noninvasive assessment of skin lesions and therapy guidance

      Fiber-based hand-held RCM-OCT probe for noninvasive assessment of skin lesions and therapy guidance

      Noninvasive assessment of skin lesions, especially of basal cell carcinoma (BCC), has benefited more recently from the use of optical imaging techniques such as optical coherence tomography (OCT) and reflectance confocal microscopy (RCM). While RCM provides submicron scale resolution and thus enables identification of skin morphological changes of the skin, with the downside of limited penetration depth, OCT imaging of the same lesion brings the benefit of better resolving its depth of invasion. OCT and RCM can be used either individually or combined within the same instrument for the noninvasive diagnosis of nonmelanoma skin cancers (NMSCs). Their combined use has ...

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    2. Multimodal Considerations Concerning Basal Cell Carcinoma Clefting – Profile of Structural and Aggressive Traits – Perspectives

      Multimodal Considerations Concerning Basal Cell Carcinoma Clefting – Profile of Structural and Aggressive Traits – Perspectives

      Although basal cell carcinoma is a well-known tumor with confirmed clinical and histopathology traits, prognosis factors and treatment options, new facets of this tumor emerge as innovative approach methods develop. Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) allow a basal cell carcinoma’s in vivo analysis of its depth of invasion, tumor margins prior to surgical approach and the tumor’s response to a non-invasive treatment, evaluating simultaneously the tumor’s vasculature. By RCM and OCT analysis, basal cell carcinoma has registered a groundbreaking discovery regarding a small (but with predictive factor potential) trait – the cleft, developing in ...

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    3. Riehl's Melanosis: A Multimodality, In Vivo, Real-Time Skin Imaging Study with Cellular Resolution Optical Coherence Tomography and Advanced Skin Diagnosis System in a Tertiary Medical Center

      Riehl's Melanosis: A Multimodality, In Vivo, Real-Time Skin Imaging Study with Cellular Resolution Optical Coherence Tomography and Advanced Skin Diagnosis System in a Tertiary Medical Center

      Background: Riehl's melanosis is a psychologically devastating hyperpigmentary disorder that typically occurs on the face and neck. The study of Riehl's melanosis is limited due to its rarity, variable morphology, and lack of noninvasive diagnostic tools. Recent advances in skin imaging analysis and diagnostic systems improve diagnostic accuracy and enable the noninvasive, real-time evaluation of pigmentary disease. A comprehensive study of Riehl's melanosis clinical morphology with multimodality and in vivo skin imaging systems has yet to be reported. Objectives: To investigate the clinical features and in vivo advanced skin imaging findings of Riehl's melanosis. Methods: We ...

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    4. Utility of optical coherence tomography in basal cell naevus syndrome: A case report

      Utility of optical coherence tomography in basal cell naevus syndrome: A case report

      Optical Coherence Tomography (OCT) is a useful non-invasive diagnostic tool for diagnosing and monitoring treatment of basal cell carcinomas. We describe the use of OCT in a patient with Basal Cell Naevus Syndrome. Through measuring tumour depth on OCT, management of individual tumours was triaged accordingly using 0.4 mm tumour depth as a cut-off for surgical and non-surgical management. OCT has potential to reduce unnecessary excisions and associated morbidity in this population of patients.

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    5. Non – Invasive diagnostic techniques in the preoperative setting of Mohs micrographic surgery: a review of the literature

      Non – Invasive diagnostic techniques in the preoperative setting of Mohs micrographic surgery: a review of the literature

      Introduction Mohs micrographic surgery (MMS) is considered the gold standard treatment for skin cancers. Though the high cure rates it offers, MMS presents some disadvantages, as it is a relatively time – consuming procedure involving several professionals (physicians and technicians). A better definition of tumor margins in the pre-operative setting with any optical non-invasive diagnostic method may reduce the numbers of MMS steps and the overall duration of the procedure. Materials and Methods The present review was conducted and reported using validated search strategies from the following databases: PUBMED and Ovid MEDLINE. Results Our review describes the use of procedures such ...

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    6. Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

      Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

      Skin cancer is one of the most common cancers worldwide. Diagnosis relies on visual inspection and dermoscopy followed by biopsy for histopathological confirmation. While the sensitivity of dermoscopy is high, the lower specificity results in 70%-80% of the biopsies being diagnosed as benign lesions on histopathology (false positives on dermoscopy). Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) imaging can noninvasively guide the diagnosis of skin cancers. RCM visualizes cellular morphology in en-face layers. It has doubled the diagnostic specificity for melanoma and pigmented keratinocytic skin cancers over dermoscopy, halving the number of biopsies of benign lesions. RCM ...

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    7. Line-Field Confocal Optical Coherence Tomography of Lentigo Maligna with Horizontal and Vertical Histopathologic Correlations

      Line-Field Confocal Optical Coherence Tomography of Lentigo Maligna with Horizontal and Vertical Histopathologic Correlations

      Lentigo maligna (LM) is a subtype of in situ melanoma that classically presents in elderly patients as a slowly growing lesion on sun-exposed areas that may evolve to invasive melanoma (LMM). Line-field confocal optical coherence tomography (LC-OCT) is a new non-invasive technique for a real-time, vertical and horizontal skin imaging with high resolution close to conventional histopathology. We present the LC-OCT features of a LM of the nose in 49-year-old white man along with their horizontal and vertical histopathological correlations. LC-OCT was able to detect in vivo, in both horizontal and vertical imaging, the main microscopic features typical of LM ...

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    8. The role of basal sweating in maintaining skin hydration in the finger: a long-standing paradox in dry skin resolved

      The role of basal sweating in maintaining skin hydration in the finger: a long-standing paradox in dry skin resolved

      long-standing paradox in dermatology is why skin dehydration in the fingers can be triggered by repeated water exposure despite the action of water to hydrate skin tissue. Potential clues might be provided by identifying a mechanism through which water is held in the skin of the fingers. We speculated that this mechanism would be impaired after repeated water exposure. Here, we investigated whether there might be glabrous skin-specific water-holding machinery and whether this machinery might be impaired in dry skin/hand eczema. We examined this by using an impression-mold technique, allowing for an accurate quantification of sweat gland/duct activity ...

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    9. Changes in function and morphology of normal human skin: evaluation using optical coherence tomography

      Changes in function and morphology of normal human skin: evaluation using optical coherence tomography

      Background Optical coherence tomography (OCT) is a noninvasive morphological method for investigating human skin. It allows high-resolution in vivo imaging of inflammatory skin diseases and tumours. Because it is a newly developed method, systematic studies on standardization and on evaluation of factors influencing the representation of the skin have not yet been performed. Objectives In this study, normal human skin was treated with various external stimuli which induce changes of function and morphology. Changes in stratum corneum thickness as well as changes induced by pigmentation, oedema and erythema were investigated using OCT. Methods Healthy skin of human volunteers was treated ...

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    10. Morphologic evaluation of melanocytic lesions with three-dimensional line-field confocal optical coherence tomography: correlation with histopathology and reflectance confocal microscopy. A pilot study

      Morphologic evaluation of melanocytic lesions with three-dimensional line-field confocal optical coherence tomography: correlation with histopathology and reflectance confocal microscopy. A pilot study

      Background Line-field confocal optical coherence tomography (LC-OCT) is a new in vivo emerging technique which provides cellular resolution, imaging depth (400 μm) and produces real-time images in both the horizontal and vertical plane and in 3 dimensions (3D). No previous description of different subtypes of melanocytic lesions and their correlation with histopathology and reflectance confocal microscopy has been reported. Objectives We aimed to describe the features of melanocytic lesions by LC-OCT and their correlation with histopathology and reflectance confocal microscopy (RCM). Methods Selected melanocytic benign lesions and melanomas were imaged in vivo with RCM and LC-OCT at the Hospital Clinic ...

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    11. Semisupervised representative learning for measuring epidermal thickness in human subjects in optical coherence tomography by leveraging datasets from rodent models

      Semisupervised representative learning for measuring epidermal thickness in human subjects in optical coherence tomography by leveraging datasets from rodent models

      Significance: Morphological changes in the epidermis layer are critical for the diagnosis and assessment of various skin diseases. Due to its noninvasiveness, optical coherence tomography (OCT) is a good candidate for observing microstructural changes in skin. Convolutional neural network (CNN) has been successfully used for automated segmentation of the skin layers of OCT images to provide an objective evaluation of skin disorders. Such method is reliable, provided that a large amount of labeled data is available, which is very time-consuming and tedious. The scarcity of patient data also puts another layer of difficulty to make the model more generalizable. Aim ...

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    12. The Effect of Different Optical Clearing Agents on the Attenuation Coefficient and Epidermal Thickness of Human Skin Assessed by Optical Coherence Tomography

      The Effect of Different Optical Clearing Agents on the Attenuation Coefficient and Epidermal Thickness of Human Skin Assessed by Optical Coherence Tomography

      Background : Optical coherence tomography (OCT) is a non-invasive imaging technique based on the interferometry of backscattered light. However, strong light scattering hinders its applicability in clinical dermatology. The strength of scattering is exemplified by the attenuation coefficient which is the rate of OCT signal decay in depth. Attenuation can be reduced by topical application of hyperosmotic liquids with a high refractive index, namely optical clearing agents (OCAs). In this study, we assessed the impact of different OCAs to enhance skin optical permeability in OCT images. In vivo tests were carried out to determine the OCT attenuation coefficient (μ OCT ) and epidermal ...

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    13. Vanderbilt University Receives NIH Grant for Smart-phone-integrated, non-invasive, depth-resolved optical spectroscopy for the detection of neonatal jaundice

      Vanderbilt University Receives NIH Grant for Smart-phone-integrated, non-invasive, depth-resolved optical spectroscopy for the detection of neonatal jaundice

      Vanderbilt University Received a 2022 NIH Grant for $448,463 for Smart-phone-integrated, non-invasive, depth-resolved optical spectroscopy for the detection of neonatal jaundice. The principal investigator is Audrey Bowden. Below is a summary of the proposed work. Newborns have immature liver function that is inefficient at metabolizing bilirubin. Consequently, nearly 80% of preterm and 60% of term babies develop hyperbilirubinemia resulting in neonatal jaundice within a week of their birth. As severe hyperbilirubinemia can be fatal, early, frequent and accurate monitoring of bilirubin is vital to avoid severe health issues and determine appropriate treatment. The gold standard for detecting hyperbilirubinemia is ...

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    14. Mirau-based line-field confocal optical coherence tomography for three-dimensional high-resolution skin imaging

      Mirau-based line-field confocal optical coherence tomography for three-dimensional high-resolution skin imaging

      Significance: Line-field confocal optical coherence tomography (LC-OCT) is a recently introduced high-resolution imaging modality based on a combination of low-coherence optical interferometry and reflectance confocal optical microscopy with line illumination and line detection. Capable of producing three-dimensional (3D) images of the skin with cellular resolution, in vivo , LC-OCT has been mainly applied in dermatology and dermo-cosmetology. The LC-OCT devices capable of acquiring 3D images reported so far are based on a Linnik interferometer using two identical microscope objectives. In this configuration, LC-OCT cannot be designed to be a very compact and light device, and the image acquisition speed is limited ...

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      Mentions: Damae Medical
    15. Michelson Diagnostics OCT points to reduced invasive biopsies

      Michelson Diagnostics OCT points to reduced invasive biopsies

      A clinical study published in The Lancet Oncology has evaluated the potential value of OCT technology in the treatment and care of basal cell carcinomas (BCC). The trial compared OCT-guided diagnosis of skin lesions with the standard punch biopsies in which small tissue samples are removed using a circular surgical instrument. The VivoSight OCT platform from Michelson Diagnostics was employed in the study, which involved 598 enrolled participants in the Netherlands. VivoSight is a multi-beam OCT platform employing light beams focused at different depths, designed to provide clinicians with continuous images of the epidermis and superficial dermis of the skin ...

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    16. 66% of diagnostic biopsies for common skin cancer can be avoided using Michelson Diagnostics' VivoSight OCT laser scanner

      66% of diagnostic biopsies for common skin cancer can be avoided using Michelson Diagnostics' VivoSight OCT laser scanner

      A major study published in leading cancer journal, The Lancet Oncology 1 have ground-breaking findings on Michelson Diagnostics, the UK based medical device company that use multi-beam Optical Coherence Tomography ('OCT') technology, which can transform patient's treatment and care of basal cell carcinomas (BCC). It was concluded that OCT-guided diagnosis, when compared to a standard punch biopsy could reduce the number of consultations and invasive procedures by a massive 66%. Professor Klara Mosterd performing an OCT scan on a patient’s lesion. Stitched skin biopsy wound Approximately 75% of skin cancers diagnosed in the UK are basal cell carcinomas ...

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    17. Optical coherence tomography versus punch biopsy for diagnosis of basal cell carcinoma: a multicentre, randomised, non-inferiority trial

      Optical coherence tomography versus punch biopsy for diagnosis of basal cell carcinoma: a multicentre, randomised, non-inferiority trial

      Background Punch biopsy is the gold standard for diagnosis and subtyping of basal cell carcinoma. The aim of this study was to assess whether use of optical coherence tomography (OCT), a non-invasive imaging tool, might avoid the need for biopsy. Methods In a multicentre, randomised, non-inferiority trial, patients (aged ≥18 years) with an indication for biopsy of a suspected basal cell carcinoma outside the H-zone (high-risk zone) of the face were randomly assigned (1:1) to receive either OCT or punch biopsy (regular care) via a web-based randomisation system. Patients were enrolled from three participating centres in the Netherlands: Maastricht ...

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    18. Multimodal system for optical biopsy of melanoma with integrated ultrasound, optical coherence tomography and Raman spectroscopy

      Multimodal system for optical biopsy of melanoma with integrated ultrasound, optical coherence tomography and Raman spectroscopy

      We introduce a new single-head multimodal optical system that integrates optical coherence tomography (OCT), 18 MHz ultrasound (US) tomography and Raman spectroscopy (RS) allowing for fast (< 2 min) and non-invasive skin cancer diagnostics and lesion depth measurement. The OCT can deliver structural and depth information of smaller skin lesions (< 1 mm), while the US allows to measure the penetration depth of thicker lesions (≥ 4 mm), and the RS analyzes the chemical composition from a small chosen spot (≤ 300 μm) that can be used to distinguish between benign and malignant melanoma. The RS and OCT utilize the same scanning and optical ...

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    19. Photoaging and Sequential Function Reversal with Cellular-Resolution Optical Coherence Tomography in a Nude Mice Model

      Photoaging and Sequential Function Reversal with Cellular-Resolution Optical Coherence Tomography in a Nude Mice Model

      Although nude mice are an ideal photoaging research model, skin biopsies result in inflammation and are rarely performed at baseline. Meanwhile, studies on antiphotoaging antioxidants or rejuvenation techniques often neglect the spontaneous reversal capacity. Full-field optical coherence tomography (FFOCT) can acquire cellular details noninvasively. This study aimed to establish a photoaging and sequential function reversal nude mice model assisted by an in vivo cellular resolution FFOCT system. We investigated whether a picosecond alexandrite laser (PAL) with a diffractive lens array (DLA) accelerated the reversal. In the sequential noninvasive assessment using FFOCT, a spectrophotometer, and DermaLab Combo ® , the photodamage percentage recovery ...

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    20. Non-Melanoma Skin Cancer Clearance after Medical Treatment Detected with Noninvasive Skin Imaging: A Systematic Review and Meta-Analysis

      Non-Melanoma Skin Cancer Clearance after Medical Treatment Detected with Noninvasive Skin Imaging: A Systematic Review and Meta-Analysis

      Background/Objectives: Non-melanoma skin cancer (NMSC) treated with nonsurgical therapies can be monitored with noninvasive skin imaging. The precision of dermoscopy, reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) in detecting clearance is unclear. We aim to report the proportion of persisting tumors identified with noninvasive technologies available in the literature. Methods: A systematic literature search was conducted on the PubMed and Cochrane Public Library Databases for articles published prior to November 2021. Statistical analyses were conducted with MedCalc 14.8.1 software. Results: A total of eight studies (352 lesions) reporting noninvasive imaging for NMSC clearance following nonsurgical ...

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    21. Multimodal Approach of Optical Coherence Tomography and Raman Spectroscopy Can Improve Differentiating Benign and Malignant Skin Tumors in Animal Patients

      Multimodal Approach of Optical Coherence Tomography and Raman Spectroscopy Can Improve Differentiating Benign and Malignant Skin Tumors in Animal Patients

      As in humans, cancer is one of the leading causes of companion animal mortality. Up to 30% of all canine and feline neoplasms appear on the skin or directly under it. There are only a few available studies that have investigated pet tumors by biophotonics techniques. In this study, we acquired 1115 optical coherence tomography (OCT) images of canine and feline skin, lipomas, soft tissue sarcomas, and mast cell tumors ex vivo, which were subsequently used for automated machine vision analysis. The OCT images were analyzed using a scanning window with a size of 53 × 53 μm. The distributions of ...

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    22. New insights from non-invasive imaging: from prospection of skin photodamages to training with mobile application

      New insights from non-invasive imaging: from prospection of skin photodamages to training with mobile application

      The incidence of non-melanoma skin cancer is on the rise and melanoma is among the most common cancers in the United States. Establishing an early diagnosis is essential for improving the prognosis of patients with skin cancer. High-resolution non-invasive imaging techniques may represent key tools for helping to identify and monitor early signs of skin cancer in seemingly healthy skin. Cumulative lifetime sun exposure leads to photoaging and photocarcinogenenis and the reaction of the skin to this solar-induced damage is balanced between the DNA repair and photoprotection defence mechanisms of melanocytes and keratinocytes. In the first part of this article ...

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    1-24 of 1194 1 2 3 4 ... 48 49 50 »
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