Dermatology -Optical Coherence Tomography News

Articles in category: Dermatology

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1. Study shows VivoSight OCT could help Eyelid Cancer Surgery
  
  Explore Optical Coherence Tomography News May 21 2013 Dermatology , Other Business News
  
  Michelson Diagnostics Press Release - In what is believed to be the first ever study to investigate OCT (Optical Coherence Tomography) imaging of skin cancers in the eyelids and skin surrounding the eye, the Dept of Opthalmology, Maidstone and Tunbridge Wells NHS Trust have shown that OCT scanning can accurately reveal the margins of tumours. The study, which was conducted using the market leading VivoSight OCT scanner manufactured by Michelson Diagnostics, showed a positive correlation between tumour margins located using OCT and histology, the 'gold standard'. This breakthrough could ultimately lead to routine use of OCT scanning to plan delicate eyelid ...
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  Mentions: Michelson Diagnostics Michelson Diagnostics Vivosight
2. Noninvasive characterization of fractional photothermolysis induced by ablative and non-ablativelasers with optical coherence tomography
  
  Explore IOPscience May 20 2013 Dermatology
  
  $Noninvasive characterization of fractional photothermolysis induced by ablative and non-ablativelasers with optical coherence tomography$
  In this study, an optical coherence tomography (OCT) system is implemented for the noninvasive characterization of photothermolysis in human skin induced by ablative fractional lasers (AFLs) and non-ablative fractional lasers (NAFLs). With OCT imaging, microthermal zones (MTZs) induced by fractional lasers can be noninvasively visualized, and the size of induced MTZs can be quantitatively evaluated. According to the OCT results, the center region of the induced MTZ corresponds to weaker backscattered intensity after the AFL exposure as a result of tissue volatilization by photon energy. In contrast, after the NAFL exposure, the skin tissue is damaged and coagulated but not ...
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  Mentions: Meng-Tsan Tsai Chang Gung University
3. High-Definition Optical Coherence Tomography (HD-OCT)
  
  Explore Agfa HealthCare — May 17 2013 Dermatology , Oncology
  
  Munich Germany, Priv. Doz. Dr. Gerald Messer (Munich, Germany) makes use of an AGFA SKINTELL unit for test purpose. He is quite impressed about the new technologies performance, especially in diagnosis of non-melanoma skin cancer. A first test is so promising that a second closer look will be done with associated clinics in June. “The new High-Definition Optical Coherence Tomography (HD-OCT) technology will give the opportunity to diagnose actinic keratosis and basal cell carcinoma without intervention in an early stage where non-invasive therapies are promising”. Dr. Messer reported also some success from the DDG (Deutsche Dermatologische Gesellschaft) Congress that was ...
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  Mentions: AGFA Healthcare AGFA SKINTELL
4. Interest of High Definition Optical Coherent Tomography (HD‐OCT) for imaging of melanoma
  
  Explore Wiley Online Library May 16 2013 Dermatology
  
  We read with interest two recent studies which established that High Definition Optical Coherent Tomography (HD-OCT), a newly released skin imaging technique, facilitates the in vivo diagnosis of non-melanoma skin cancers (1, 2). However, to the best of our knowledge there is no data available regarding HD-OCT and melanoma. A 61-year-old man, skin type II, with a previous history of melanoma 10 years before consulted for a follow-up visit. Clinical and dermoscopic examination pointed to two suspicious pigmented lesions in the right pectoral region and on the left scapula. RCM examination using a commercially available VivaScope ® 1500 (Lucid-Tech Inc., Henrietta ...
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  Mentions: AGFA Healthcare AGFA SKINTELL
5. In vivo optical coherence tomography (OCT) in periocular basal cell carcinoma: correlations between in vivo OCT images and postoperative histology
  
  Explore BJO Online May 15 2013 Dermatology , Ophthalmology
  
  Aim To investigate in vivo optical coherence tomography (OCT) for imaging of periocular basal cell carcinoma (BCC). Methods Consecutive patients with periocular BCC were prospectively investigated with VivoSight OCT imaging prior to surgical excision. Histology sections were compared with OCT images with regard to lesion measurements (x, y and z dimensions) and histological features. Results A total of 15 patients with biopsy proven BCC were recruited. The OCT horizontal margins correlated positively with histology (r=0.8 and 0.66, x and y axes) and could be identified in 3/15 (x axis) and 6/15 (y axis) cases. The ...
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  Mentions: Michelson Diagnostics Michelson Diagnostics Vivosight
6. Functional and structural age-related changes in the scalp skin of Caucasian women
  
  Explore Wiley Online Library May 9 2013 Dermatology
  
  Background Ageing of the skin, being chronological or sun induced is highly documented. Scalp, as a specific skin site, has, however, received little attention. This work attempted to describe functional and structural alterations that occur in scalp skin with ageing. Methods Two different age groups (N = 15 each; 30 ± 3 and 62 ± 2 y.o. respectively) of Caucasian women participated in the study. Some functional parameters (TEWL, Sebum level, Hydration, T°) were recorded on the vertex part of the scalp, after having cut the hair flat on the scalp surface. Imaging of some structural criteria was carried out using high-frequency ...
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7. Calluses, Corns and Heel Fissures
  
  Explore ingentaconnect.com May 1 2013 Dermatology
  
  Hypertrophy of the plantar stratum corneum (SC) of the epidermis (also known as hyperkeratosis) is one of the skin's primary protective responses, triggered by either physiological stresses, a result of underlying disease (eg, psoriasis, palmoplantar keratoderma), or external mechanical stresses. In the case of the foot the most common presentations of hyperkeratosis are: anhidrosis, calluses, corns and heel fissures. This article reviews the current evidence in the field of hyperkeratosis of the foot and will present the treatment options available to practitioners and patients. The gaps in the knowledge surrounding the efficacy of treatments are discussed and novel methods ...
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  Mentions: Michelson Diagnostics Michelson Diagnostics Vivosight
8. Feasibility of correlation mapping optical coherence tomography (cmOCT) for anti-spoof sub-surface fingerprinting
  
  Explore Wiley Online Library Apr 28 2013 Dermatology , Other Non-Medical
  
  We propose the use of correlation mapping optical coherence tomography (cmOCT) to deliver additional biometrics associated with the finger that could complement existing fingerprint technology for law enforcement applications. The current study extends the existing fingerprint paradigm by measuring additional biometrics associated with sub-surface finger tissue such as sub-surface fingerprints, sweat glands, and the pattern of the capillary bed to yield a user-friendly cost effective and anti-spoof multi-mode biometric solution associated with the finger. To our knowledge no other method has been able to capture sub-surface fingerprint, papillary pattern and horizontal vessel pattern in a single scan or to show ...
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  Mentions: Kirill V. Larin University of Houston Hrebesh M. Subhash
9. Combined reflectance confocal microscopy/optical coherence tomography imaging for skin burn assessment
  
  Explore opticsinfobase.org Apr 13 2013 Dermatology
  
  A combined high-resolution reflectance confocal microscopy (RCM)/optical coherence tomography (OCT) instrument for assessing skin burn gravity has been built and tested. This instruments allows for visualizing skin intracellular details with submicron resolution in the RCM mode and morphological and birefringence modifications to depths on the order of 1.2 mm in the OCT mode. Preliminary testing of the dual modality imaging approach has been performed on the skin of volunteers with some burn scars and on normal and thermally-injured Epiderm FTTM skin constructs. The initial results show that these two optical technologies have complementary capabilities that can offer the ...
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  Mentions: Massachusetts General Hospital Harvard University Physical Sciences Incorporated
10. Positional differences and aging changes in Japanese woman epidermal thickness and corneous thickness determined by OCT (optical coherence tomography)
  
  Explore Wiley Online Library Apr 12 2013 Dermatology
  
  Background/purpose A number of studies of the internal structure of Japanese woman's skin are now performed by means of optical coherence tomography (OCT) as a technique capable of visualizing the internal structure in a non-invasive manner. Methods We measured the epidermal and corneous thicknesses at 11 sites in 116 healthy female volunteers aged from teens to sixties to examine possible positional differences and aging changes. Results The epidermal thickness determined at the 11 sites averaged 68.6 ± 23.0 μm (mean ± SD) and the corneous thickness averaged 14.1 ± 1.80 μm, the values of which were thinner ...
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11. Optical coherence tomography: its role in daily dermatological practice
  
  Explore Wiley Online Library Apr 10 2013 Dermatology
  
  Optical coherence tomography (OCT) is a non-invasive, tomographic imaging technique which generates high-resolution in-vivo images up to mid-dermal layers. Due to continuous technological improvements, OCT is moving from research projects into daily dermatological practice. It can complement other imaging methods like high-frequency ultrasound or confocal microscopy. There is a wide variety of indications for OCT. In addition to aiding in the diagnosis and clinical monitoring of inflammatory dermatoses, OCT is a very useful and feasible technique in dermato-oncology.
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  Mentions: Michelson Diagnostics Michelson Diagnostics Vivosight
12. Optical techniques for the noninvasive diagnosis of skin cancer
  
  Explore Home - Springer Apr 6 2013 Dermatology
  
  Purpose The aim of this paper is to provide an overview of the most investigated optical diagnostic techniques: optical coherence tomography, fluorescence spectrometry, reflectance spectrometry, Raman spectroscopy, and confocal microscopy. Methods A search of three databases was conducted using specific keywords and explicit inclusion and exclusion criteria for the analysis of the performances of these techniques in the pre- and postoperative diagnosis of skin cancers. Results Optical coherence tomography has shown promising results in the assessment of deep margins of skin tumors and inflammatory skin diseases, but differentiating premalignant from malignant lesions proved to be less effective. Fluorescence spectroscopy proved ...
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13. Evaluation of Moisture-Related Attenuation Coefficient and Water Diffusion Velocity in Human Skin Using Optical Coherence Tomography
  
  Explore MDPI Open Access Journals Platform Apr 1 2013 Dermatology
  
  In this study, time-resolved optical coherence tomography (OCT) scanning images of the process of water diffusion in the skin that illustrate the enhancement in the backscattered intensities due to the increased water concentration are presented. In our experiments, the water concentration in the skin was increased by soaking the hand in water, and the same region of the skin was scanned and measured with the OCT system and a commercial moisture monitor every three minutes. To quantitatively analyze the moisture-related optical properties and the velocity of water diffusion in human skin, the attenuation coefficients of the skin, including the epidermis ...
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  Mentions: Meng-Tsan Tsai Cheng-Kuang Lee Chang Gung University
14. Investigation of basal cell carcinoma using dynamic focus optical coherence tomography
  
  Explore opticsinfobase.org Mar 27 2013 Dermatology
  
  Optical coherence tomography (OCT) is becoming a popular modality for skin tumor diagnosis and assessment of tumor size and margin status. We conducted a number of imaging experiments on periocular basal cell carcinoma (BCC) specimens using an OCT configuration. This configuration employs a dynamic focus (DF) procedure where the coherence gate moves synchronously with the peak of the confocal gate, which ensures better signal strength and preservation of transversal resolution from all depths. A DF-OCT configuration is used to illustrate morphological differences between the BCC and its surrounding healthy skin in OCT images. The OCT images are correlated with the ...
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  Mentions: Adrian G. Podoleanu University of Kent
15. Sonography of Facial Cutaneous Basal Cell Carcinoma - A First-line Imaging Technique
  
  Explore jultrasoundmed.org Mar 23 2013 Dermatology
  
  Cutaneous basal cell carcinoma is the most common cancer in human beings, and the face is its most frequent location. Basal cell carcinoma is rarely lethal but can generate a high degree of disfigurement. Of all imaging techniques, sonography has proven to support the diagnosis and provide detailed anatomic data on extension in all axes, the exact location, vascularity, and deeper involvement. This information can be used for improving management and the cosmetic results of patients. Next Section Overview and Description of the Clinical Problem Even though the diagnosis of skin cancer predominantly relies on clinical inspection, imaging techniques are ...
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16. Optical Coherence Tomography: The first Quantitative Imaging Biomarker for Scleroderma
  
  Explore Optical Coherence Tomography News Mar 19 2013 Dermatology
  
  Michelson Diagnostics Press Release - Using the VivoSight OCT scanner, manufactured in the UK by Michelson Diagnostics Ltd, scientists at the Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds have developed the first quantitative imaging biomarker for skin involvement in Scleroderma. Scleroderma or Systemic Sclerosis (SSc) is a serious type of autoimmune disorder affecting approximately 1 in 10,000 people. It is a progressive disease that involves skin and internal organs by determining fibrosis, vasculopathy and immune system activation. The extent and severity of skin fibrosis is an important prognostic indicator of Scleroderma and often a primary endpoint in clinical ...
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  Mentions: Michelson Diagnostics Daniel Woods University of Leeds
17. Defense of fake fingerprint attacks using a swept source laser optical coherence tomography setup
  
  Explore Conference Proceedings Mar 18 2013 Dermatology , Other Non-Medical
  
  The most established technique for the identification at biometric access control systems is the human fingerprint. While every human fingerprint is unique, fingerprints can be faked very easily by using thin layer fakes. Because commercial fingerprint scanners use only a two-dimensional image acquisition of the finger surface, they can only hardly differentiate between real fingerprints and fingerprint fakes applied on thin layer materials. A Swept Source OCT system with an A-line rate of 20 kHz and a lateral and axial resolution of approximately 13 μm, a centre wavelength of 1320 nm and a band width of 120 nm (FWHM) was ...
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  Mentions: Sven Meissner Dresden University of Technology Edmund Koch
18. Dynamic imaging of a small artery underneath skin surface of a human finger by optical coherence tomography
  
  Explore scirp.org Mar 18 2013 Dermatology
  
  OCT is a powerful tool for detection of physiological functions of micro organs underneath the human skin surface, besides the clinical application to ophthalmology, as recently demonstrated by the authors’ group. In particular, dynamics of peripheral vessels can be observed clearly in the time-sequential OCT images. Among the vascular system, only the small artery has two physiological functions both for the elastic artery and for muscle-controlled one. It, therefore, is important for dynamic analysis of blood flow and circulation. In the time-sequential OCT images obtained with 25 frames/sec, it is found that the small artery makes a sharp ...
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  Mentions: Osaka University
19. Interview with Jon Holmes of Michelson Diagnostics (Video)
  
  Explore Laser Focus World Mar 16 2013 Dermatology
  
  BioOptics World editor-in-chief Barbara Goode inteviews Jon Holmes of Michelson Diagnostics, which produces an optical coherence tomography (OCT) system that aids clinical treatment of precancerous lesions and non-melanoma skin cancer.
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  Mentions: Michelson Diagnostics Jon Holmes FDA
20. Virtual Biopsy – is it possible?
  
  Explore Pharmaceutical Intelligence Mar 15 2013 Dermatology
  
  In a remark made to my last post: New envelopment in measuring mechanical properties of tissue , Dr. Aviva Lev-Ari, PhD, RN, Director and Founder of our Open Access Online Scientific Journal: Leaders of Pharmaceutical Business Intelligence, asked whether OCT can be used for the purpose of performing biopsy. My answer to her question was “YES”. I thought that it will be worthwhile explaining why I am so “optimistic” about this: A conventional biopsy is a process where a tissue sample is being cut out of the body and after being subjected to all kind of chemical processes a thin-film of ...
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21. Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative
  
  Explore Conference Proceedings Mar 12 2013 Dermatology
  
  The effects on skin of two commercially available topical creams for the treatment of eczema are quantitatively studied using optical coherence tomography. An archetypal corticosteroid (Betamethasone valerate) is compared with a nonsteroidal anti-inflammatory drug (Tacrolimus monohydrate) via left/right comparisons of the epidermal thickness of volar forearm skin on selected volunteers, at baseline and after 14 days of treatment. In 3 of 4 subjects we confirmed previous observations that corticosteroids produce pronounced physical thinning of the epidermis over timescales of a few weeks. In 3 of 4 subjects we further found that Tacrolimus produced no change in epidermal thickness. In ...
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  Mentions: University of Sheffield Steven J. Matcher
22. Non-invasive Quality Control for Production Processes of Artificial Skin Equivalents by Optical Coherence Tomography
  
  Explore ScienceDirect Mar 10 2013 Dermatology
  
  The engineering of artificial tissue and organs is widely gaining relevance in biotechnological and biomedical research. Particularly by the law enforced reduction of animal testing, alternative methods need to be developed to simulate and test the effects of chemical substances on human organs. Regarding the branches for pharmaceuticals, chemicals and cosmetics most products need to be tested on penetration of the human skin tissue. As an alternative method to animal testing, skin equivalents (SEs) based on tissue engineering may be used to test the skin barrier function. In the framework of a large scale research project, we built a fully ...
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  Mentions: RWTH Aachen University Robert Schmitt
23. Optical coherence tomography imaging of telangiectasias during intense pulsed light treatment: a potential tool for rapid outcome assessment
  
  Explore Home - Springer Mar 5 2013 Dermatology
  
  Vascular malformations commonly occur in the facial region, and can be associated with significant stigma and embarrassment. Studies have shown that even recommended light-based treatments do not always result in complete clearance. This indicates the need for more accurate pre-treatment assessment of vessel morphology to optimize treatment settings and identify possible morphological predictors of the outcome. Fourteen patients (six males, eight females, and aged 37–66 years) with the diagnosis of telangiectasias were enrolled and were all scanned with OCT and digitally photographed before and minutes after IPL treatment. OCT images of the telangiectasias before treatment were displayed as hyporeflective ...
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  Mentions: Mette Mogensen University of Copenhagen Gregor B. E. Jemec
24. In vivo microcirculation imaging of the sub surface fingertip using correlation mapping optical coherence tomography (cmOCT)
  
  Explore Conference Proceedings Mar 5 2013 Dermatology
  
  We describe a novel application of correlation mapping optical coherence tomography (cmOCT) for sub-surface fingerprint biometric identification. Fingerprint biometrics including automated fingerprint identification systems, are commonly used to recognise the fingerprint, since they constitute simple, effective and valuable physical evidence. Spoofing of biometric fingerprint devices can be easily done because of the limited information obtained from the surface topography. In order to overcome this limitation a potentially more secure source of information is required for biometric identification applications. In this study, we retrieve the microcirculation map of the subsurface fingertip by use of the cmOCT technique. To increase probing depth ...
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  Mentions: Thorlabs Kirill V. Larin University of Houston
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