1. Articles in category: Dermatology

    1-24 of 911 1 2 3 4 ... 36 37 38 »
    1. Optical Coherence Tomography in Diagnosis of Inflammatory Scalp Disorders

      Optical Coherence Tomography in Diagnosis of Inflammatory Scalp Disorders

      Background The common inflammatory scalp disorders share similar clinical manifestations, and patient work up require invasive, undesirable diagnostic procedures like biopsy to ensure correct diagnosis. Optical coherence tomography (OCT) is a noninvasive high‐resolution imaging modality that has found a valuable tool to assist in the diagnose and evaluation of different skin diseases. Objectives To describe the structural and vascular dynamic OCT (D‐OCT) findings of inflammatory scalp disorders including scalp psoriasis, seborrheic dermatitis and contact dermatitis, and to compare trichoscopy and OCT features. Methods Subjects with diagnosis of seborrheic dermatitis, psoriasis, or contact dermatitis were enrolled in this study ...

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    2. Noninvasive Techniques for Quantification of Contact Dermatitis

      Noninvasive Techniques for Quantification of Contact Dermatitis

      The pathophysiology of contact dermatitis includes specific morphological and physiological changes in the skin as a result of the direct toxic effect of exogenous agents and the subsequent inflammatory cascade. These reactions can be quantified by a variety of noninvasive devices. Classical biophysical methods such as the assessment of transepidermal water loss, stratum corneum hydration, and laser Doppler flowmetry are widely used in the investigation, quantification, and discrimination of irritant and allergic reactions of the skin. Novel in vivo techniques such as in vivo Raman spectroscopy have emerged, and the body of evidence on the skin microstructure is growing. Visualization ...

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    3. Uniform focusing with an extended depth range and increased working distance for optical coherence tomography by an ultrathin monolith fiber probe

      Uniform focusing with an extended depth range and increased working distance for optical coherence tomography by an ultrathin monolith fiber probe

      It is difficult to maintain high transverse resolution over an increased depth range using miniature probes for optical coherence tomography (OCT) due to the rapid divergence of light and the space limitation. To solve this problem, we introduce a fiber-based filter in the proposed probe to manipulate its output beam. Significant mode interference (MI) is exploited to enhance the depth of focus (DOF), and the mode phase difference is tuned to achieve a uniform axial intensity within the DOF. The magnified MI field instead of the diffracted one is adopted as the final pupil filter in the probe to increase ...

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    4. Dual-mode line-field confocal optical coherence tomography for ultrahigh-resolution vertical and horizontal section imaging of human skin in vivo

      Dual-mode line-field confocal optical coherence tomography for ultrahigh-resolution vertical and horizontal section imaging of human skin in vivo

      Line-field confocal optical coherence tomography (LC-OCT) is a recently introduced technique for ultrahigh-resolution vertical section (B-scan) imaging of human skin in vivo . This work presents a new implementation of the LC-OCT technique to obtain horizontal section images (C-scans) in addition to B-scans. C-scan imaging is achieved with this dual-mode LC-OCT system using a mirror galvanometer for lateral scanning along with a piezoelectric chip for modulation of the interferometric signal. A quasi-identical spatial resolution of ∼ 1 µm is measured for both B-scans and C-scans. The images are acquired in both modes at a rate of 10 frames per second. The horizontal ...

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    5. Comparison of Normal Skin and Thermal and Chemical Burn Wounds using Vibrational Optical Coherence Tomography

      Comparison of Normal Skin and Thermal and Chemical Burn Wounds using Vibrational Optical Coherence Tomography

      he search for methods to evaluate the extent and severity of skin lesions, such as burns and other skin disorders, has been a subject of extentive research. While suction testing, elastography and other tests can be done noninvasively on intact skin, these tests cannot be done on burns and open wounds due to the possible injury that may occur. In addition, they fail to yield comparable results obtained using destructive tests such as uniaxial tensile testing. We have developed a technique to combine optical coherence tomography (OCT) with vibrational analysis (VOCT) to non-invasively and non-destructively evaluate the properties of skin ...

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      Mentions: Lumedica
    6. A Flexible Touch-based Fingerprint Acquisition Device and A Benchmark Database using Optical Coherence Tomography

      A Flexible Touch-based Fingerprint Acquisition Device and A Benchmark Database using Optical Coherence Tomography

      Optical Coherence Tomography (OCT) is a high resolution imaging technology probing the internal structure of multilayered tissues. Since it provides subsurface fingerprint information which is identical to the surface texture but unaffected by any surface defects, OCT-based fingerprints open up a new domain for establishing robust and high security automatic fingerprint identification systems (AFISs). However, the development of OCT-based fingerprint recognition is hindered by the lack of public OCT-based fingerprint database for algorithm analysis and testing. This paper, for the first time, established an OCT-based fingerprint database with thousands of fingers using our custom-built acquisition device.(The website of this ...

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    7. Compact and Mobile Full-Field Optical Coherence Tomography Sensor for Subsurface Fingerprint Imaging

      Compact and Mobile Full-Field Optical Coherence Tomography Sensor for Subsurface Fingerprint Imaging

      Conventional fingerprint sensors that are deployed in real-life applications lack the ability to peer inside a finger beyond the external surface. Subsurface information can provide complimentary biometric characteristics associated with the finger. The subsurface fingerprints can also be employed when the quality of the external/surface fingerprints is affected. One of the most promising technologies for imaging below the surface of an external fingerprint is full-field optical coherent tomography (FF-OCT). However, the FF-OCT can be expensive and cumbersome, despite its proven ability for biometric use. In this paper, we describe the design and implementation of a compact, mobile and cost-effective ...

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    8. New Device Performs 3D “Optical Biopsies” Of Skin

      New Device Performs 3D “Optical Biopsies” Of Skin

      DAMAE Medical and NKT Photonics have worked together under the Eurostar financing program to combine the cutting-edge Line-field Confocal Optical Coherence Tomography (LC-OCT) imaging technology, developed by DAMAE Medical, with the innovative supercontinuum laser technology provided by NKT Photonics. With a broadband SuperK white light laser as a key component, DAMAE Medical has developed an in vivo skin imaging device which performs “optical biopsies” based on the new LC-OCT technology. This unique technique couples the technological advantages of OCT and confocal microscopy: high resolution at high penetration depth. The broadband near-infrared light from the laser combined with high aperture microscope ...

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    9. Use of Optical Coherence Tomography (OCT) in Aesthetic Skin Assessment—A Short Review

      Use of Optical Coherence Tomography (OCT) in Aesthetic Skin Assessment—A Short Review

      Assessments of non‐surgical office‐based aesthetic treatments' efficacy including lasers are mostly based on subjective evaluation of clinical photography. Accumulating evidence suggest that non‐invasive skin imaging such as optical coherence tomography (OCT) can be effectively used to assess not only the skin surface but also the underlying epidermis and dermis, providing objective and clinically relevant data. In this review, we highlight the potential of OCT imaging for the aesthetic medicine field along with OCT measurement parameters and their clinical relevance to healthy and pathological skin conditions.

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    10. Fast Track Diagnosis of Skin Cancer by Advanced Imaging

      Fast Track Diagnosis of Skin Cancer by Advanced Imaging

      To collect data for a new image-guided diagnostic algoritm, enabling the investigators to differentiate more precisely between benign and malignant pigmented tumours at the bedside. This study will include 60 patients with four different pigmented tumours: seborrheic keratosis (n=15), dermal nevi (n=15), pigmented basal cell carcinomas (n=15), and malignant melanomas (n=15), these four types of tumours are depicted in Fig.1, and all lesions will be scanned by four imaging technologies, recruiting patients from Sept 2019 to May 2020. In vivo reflectance confocal microscopy (CM) will be used to diagnose pigmented tumours at a cellular level ...

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    11. Acquisition and Extraction of Surface and Internal Fingerprints from Optical Coherence Tomography through 3D Fully Convolutional Network

      Acquisition and Extraction of Surface and Internal Fingerprints from Optical Coherence Tomography through 3D Fully Convolutional Network

      Optical coherence tomography (OCT) is a non-destructive, high-resolution, and non-invasive imaging technique that has recently been applied to biometric field for three dimensional (3D) fingertip data acquisition. Fingertip volume data contains the epidermis and part of the dermis layers representing the surface fingerprint and internal fingerprint, respectively. As a 3D and under skin feature, internal fingerprint provides much higher anti-counterfeiting capability compared with traditional 2D fingerprints. Furthermore, it is not affected by fingertip conditions such as wet, worn out (old) and small scars/injuries. However, the extraction of surface and internal fingerprints is challenging due to the speckle noise and ...

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    12. Optical Biopsy of Melanoma and Basal Cell Carcinoma Progression by Noncontact Photoacoustic and Optical Coherence Tomography: In vivo Multi-parametric Characterizing Tumor Microenvironment

      Optical Biopsy of Melanoma and Basal Cell Carcinoma Progression by Noncontact Photoacoustic and Optical Coherence Tomography: In vivo Multi-parametric Characterizing Tumor Microenvironment

      Measuring the structural and functional status of tumor microenvironment for malignant melanoma (MM) and basal cell carcinoma (BCC) is of profound significance in understanding dermatological condition for biopsy. However, conventional optical imaging techniques are limited to visualize superficial skin features and parameter information is deficient to depict pathophysiology correlations of skin diseases. Here, we demonstrate a preclinical device, all-optically integrated photoacoustic and optical coherence tomography (AOPA/OCT), that, for the first time, can simultaneously provide label-free biomarkers of vascular patterns, temporal and spatial heterogeneity of blood flow, and tissue micro-structure changes during tumor growth with pathophysiological correlations in mice models ...

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    13. Investigation of Human Skin Tissues Using Optical Coherence Tomography (Thesis)

      Investigation of Human Skin Tissues Using Optical Coherence Tomography (Thesis)

      Over the decades various imaging technologies have been used for the investigation of skin tissues, but their poor sensitivity, specificity and accuracy limits their applications. In comparison to other imaging modalities, optical coherence tomography (OCT) is a preferred technique as it is a non-invasive imaging modality with a high resolution and is able to perform cellular level imaging as well as providing depth information. This imaging modality has been widely used to image tissues in the human body and thus manifests its potential for clinical applications. Further, OCT can be considered as the potential tool for the identification but the ...

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    14. Biomechanical Relationship Between Cells and Collagen in Skin and Skin Lesions

      Biomechanical Relationship Between Cells and Collagen in Skin and Skin Lesions

      We have used vibrational optical coherence tomography to study the relationship between cellular and collagen mechanical behavior in skin in-vivo. Quantitative measurements of the cellular and collagen resonant frequencies and peak heights were used to calculate the moduli and relative contribution of cells and collagen to the mechanical behavior of skin. Our results suggest that the resonant frequencies measured in vascularized skin are increased by arterial blood flow and is hypothesized to be a result of upregulation of mechanotransduction. The increased cell contribution to the pixel intensity and an increased resonant frequency peak height, suggests that arterial flow influences the ...

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    15. Machine-Learning Classification of Port Wine Stain With Quantitative Features of Optical Coherence Tomography Image

      Machine-Learning Classification of Port Wine Stain With Quantitative Features of Optical Coherence Tomography Image

      Port wine stain (PWS) is the benign congenital capillary malformation of skin, occurring in 0.3% to 0.5% of the population. In this paper, we build two automated support vector machine (SVM) based classifiers by extracting quantitative features from normal and PWS tissue images recorded by optical coherence tomography (OCT). We use both full feature set and simplified feature set for training. Accuracy of 92.7%, sensitivity of 92.3% and specificity of 93.8% were obtained for classifier with full feature set. Accuracy of 92.7%, sensitivity of 94.9% and specificity of 87.5% were obtained for ...

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    16. The actinic dysplasia syndrome – diagnostic approaches defining a new concept in field carcinogenesis with multiple cSCC

      The actinic dysplasia syndrome – diagnostic approaches defining a new concept in field carcinogenesis with multiple cSCC

      Usually, SCC lesions are surrounded by a number of clinically visible and non‐visible (subclinical) areas of actinically damaged skin containing cells with dysplasia, and thus may be designated actinic dysplasia syndrome. The epithelial damage is caused mainly by UV radiation, inducing mutations in keratinocytes that may confer growth advantages resulting in preneoplastic fields. The development of visible dysplastic lesions (actinic keratosis – AK) and subsequent progression to invasive SCC requires further mutations in cancer‐associated genes, like tumour suppressor genes and cell cycle regulators. Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) represent a considerable advantage for the investigation ...

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    17. Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study

      Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study

      Microvascular networks of human basal cell carcinomas (BCC) and surrounding skin were assessed with optical coherence angiography (OCA) in conjunction with photodynamic therapy (PDT). OCA images were collected and analyzed in 31 lesions pre-treatment, and immediately/24 hours/3–12 months post-treatment. Pre-treatment OCA enabled differentiation between prevalent subtypes of BCC (nodular and superficial) and nodular-with-necrotic-core BCC subtypes with a diagnostic accuracy of 78%; this can facilitate more accurate biopsy reducing sampling error and better therapy regimen selection. Post-treatment OCA images at 24 hours were 98% predictive of eventual outcome. Additional findings highlight the importance of pre-treatment necrotic core, vascular ...

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    18. Comparison of line‐field confocal optical coherence tomography images with histological sections: Validation of a new method for in vivo and non‐invasive quantification of superficial dermis thickness

      Comparison of line‐field confocal optical coherence tomography images with histological sections: Validation of a new method for in vivo and non‐invasive quantification of superficial dermis thickness

      Background Line‐field confocal optical coherence tomography (LC‐OCT) is an imaging technique providing “optical biopsies” of the skin in real time and non‐invasively. At a center optical wavelength of 1.3 µm, this innovative technology can be applied to dermo‐cosmetic product development due to both high image resolution (~2 µm) and sufficient penetration (~0.5 mm). Nevertheless, the precise dermal area analyzed with LC‐OCT has never been identified. In this study, the objective was to compare LC‐OCT images with histological sections of the same area, in order to validate a new method for in vivo ...

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      Mentions: Arnaud Dubois
    19. Optical coherence tomography in the assessment of cutaneous cancer margins of the face: an immediate ex vivo study

      Optical coherence tomography in the assessment of cutaneous cancer margins of the face: an immediate ex vivo study

      Background The assessment of cutaneous cancer margins intra-operatively or in the immediate postoperative phase can guide the operator into achieving clearer margins. Achieving a clear (tumour-free) margins following surgery is an essential factor that can reduce morbidity and disfigurement. The aim of present study was to determine the accuracy of optical coherence tomography in assessing cutaneous cancer margins of the face. Materials and Methods The excised tissue specimens that were examined, in this study, were acquired from 70 patients with 70 facial cancer lesions, with no nodal disease. Forty lesions were basal cell carcinomas (150 margins; 27 tumour positive) and ...

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    20. Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study

      Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study

      Patients undergo collection of tears, saliva, buccal mucosa, and fecal samples before stem cell transplant, at 2-3, 4, 6, 8, 10, and 12 months after stem cell transplant, and at cGVHD onset. Patients also undergo collection of blood samples before stem cell transplant, at 1-2, 2-3, 4, 6, 8, 10, and 12 months after stem cell transplant, and at cGVHD onset. Patients may undergo skin and mouth biopsy over 15-30 minutes before stem cell transplant, at 2-3 and 12 months after stem cell transplant, and at cGVHD onset. Patients undergo digital pictures of the eyes, mouth and skin, and optical ...

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    21. High-Resolution Optical Coherence Tomography (OCT) for Skin Imaging (Book Chapter)

      High-Resolution Optical Coherence Tomography (OCT) for Skin Imaging (Book Chapter)

      This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work. Imaging Technologies and Transdermal Delivery in Skin Disorders starts by outlining the structural characteristics of skin and skin appendages. It then discusses the key pathways involved in skin growth and development. Clinical ...

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    22. Capillary Refill—The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography

      Capillary Refill—The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography

      Background/Objectives: Standard optical coherence tomography angiography (OCTA) has been limited to imaging blood vessels actively undergoing perfusion, providing a temporary picture of surface microvasculature. Capillary perfusion in the skin is dynamic and changes in response to the surrounding tissue's respiratory, nutritional, and thermoregulatory needs. Hence, OCTA often represents a given perfusion state without depicting the actual extent of the vascular network. Here we present a method for obtaining a more accurate anatomic representation of the surface capillary network in human skin using OCTA, along with proposing a new parameter, the Relative Capillary Capacity (RCC), a quantifiable proxy for ...

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    1-24 of 911 1 2 3 4 ... 36 37 38 »
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