1. Articles in category: Dermatology

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    1. In vivo dual-mode full-field optical coherence tomography for differentiation of types of melanocytic nevi

      In vivo dual-mode full-field optical coherence tomography for differentiation of types of melanocytic nevi

      Significance: Melanocytic nevi represent the most common dermal melanocytic lesions in humans. Nevus is typically diagnosed clinically with the naked eye or with dermoscopy. However, it is essential to identify the type of nevus by invasive biopsy for histopathological examination. The use of noninvasive imaging tools can be used to evaluate the types of nevi to reduce unnecessary excisions of benign entities. Aim: To evaluate the feasibility of using en face and cross-sectional full-field optical coherence tomography (FF-OCT) in differentiation of melanocytic nevi that can facilitate the reduction of unnecessary excisions of benign entities. Approach: Dual-mode Mirau-type FF-OCT for cross-sectional ...

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    2. Multicenter Phenotype-Genotype Analysis of Vascular Stains to Optimize Treatment Utilizing Optical Coherence Tomography

      Multicenter Phenotype-Genotype Analysis of Vascular Stains to Optimize Treatment Utilizing Optical Coherence Tomography

      The purpose of this research study is to develop a better understanding of vascular stains and to improve the usual laser treatment for vascular stain by using optical coherence tomography (OCT). This study is being done at the University of Wisconsin-Madison (UW-Madison) and University of California, Irvine. A total of about 85 people will participate in this study.

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    3. Combining Reflective Confocal Microscopy and Dynamic Optical Coherence Tomography to Diagnose Melanoacanthoma: Case Report

      Combining Reflective Confocal Microscopy and Dynamic Optical Coherence Tomography to Diagnose Melanoacanthoma: Case Report

      Few reported cases discuss distinguishing between melanoma and melanoacanthoma , a seborrheic keratosis (SK) variant, using noninvasive imaging devices. We present a case of a 38-year-old man with Fitzpatrick skin type IV with an asymmetric black papule showing clinical and dermoscopic features of both melanoma and SK. Reflectance confocal microscopy (RCM) and dynamic optical coherence tomography (d-OCT) were used for further evaluation. RCM revealed acanthotic epidermis with a mixed honeycomb and cobblestone pattern, polycyclic bulbous rete ridges, and bright plump cells within entrapped, edged, dermal papillae, compatible with pigmented SK. Also noted were a population of fairly uniform bright dendritic cells ...

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    4. Line-field confocal optical coherence tomography of benign dermal melanocytic proliferations: a case series

      Line-field confocal optical coherence tomography of benign dermal melanocytic proliferations: a case series

      Line‐field confocal optical coherence tomography (LC‐OCT) is a recently developed non‐invasive imaging technique able to combine the technical principles of conventional OCT (high in‐tissue penetration and visualization of the vertical plane) and reflectance confocal microscopy (high resolution). 1‐3 Indeed, LC‐OCT provides tridimensional images of the skin (vertical and horizontal planes) up to a 500‐µm depth and features excellent isotropic resolution (lateral: 1.3 µm; axial: 1.1 µm).

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    5. Line‐field confocal optical coherence tomography: a novel, non‐invasive imaging technique for a rapid, in‐vivo diagnosis of herpes infection of the skin

      Line‐field confocal optical coherence tomography: a novel, non‐invasive imaging technique for a rapid, in‐vivo diagnosis of herpes infection of the skin

      Line‐field confocal optical coherence tomography (LC‐OCT) is a new non‐invasive imaging technique for a real‐time, vertical and horizontal skin imaging with high resolution close to conventional histopathology (1‐2). As LC‐OCT has recently been marketed, few studies have been reported on its use in cutaneous disorders (2‐4), in some cases with an excellent correlation with conventional histopathology (3). The objective of the present study was to evaluate the LC‐OCT features in herpes infections (HSV/HVZ) of the skin.

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    6. Optical coherence tomography-based non-invasive evaluation of premalignant lesions in SKH-1 mice

      Optical coherence tomography-based non-invasive evaluation of premalignant lesions in SKH-1 mice

      Non-invasively diagnosis of actinic keratoses (AK) is important for preventing cutaneous squamous cell carcinoma (cSCC). Optical coherence tomography (OCT) can be used to detect the cross-sectional skin micromorphology with sufficient resolution and imaging depth. It has the capability to reveal the changes in skin microstructure during the development of AK. Therefore, OCT can serve as a tool for diagnosing AK. This study explores the feasibility of OCT in evaluating the structural changes in mouse skin at the different stages following exposure to ultraviolet radiation. The performance of OCT is compared with histology, the gold standard in this context. The imaging ...

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    7. Optical Coherence Tomography Guided Laser Treatment of Basal Cell Carcinoma

      Optical Coherence Tomography Guided Laser Treatment of Basal Cell Carcinoma

      The purpose of this pilot study is to examine the treatment basal cell carcinoma (BCC) with laser technology under the guidance of optical coherence tomography imaging (OCT). The laser modality that we plan to use is the long-pulse Nd:YAG 1064nm laser, which is a non-ablative laser already shown to effectively treat BCC. Laser treatment of BCC has limited precedent in the literature, but the addition of OCT has the opportunity to enhance outcomes by better targeting the treatment and permitting more precise monitoring of clearance. We propose to use OCT imaging to guide the laser treatment to achieve optimal ...

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      Mentions: UC Irvine
    8. A Study of Noninvasive Methods to Evaluate Skin and Mucosal Conditions

      A Study of Noninvasive Methods to Evaluate Skin and Mucosal Conditions

      The purpose of this study is to find out whether using noninvasive methods to study the appearance of lesions can improve diagnostic accuracy before a biopsy is required and help guide treatment planning. The database created to store these images is called an Image Repository, and it will be used to support clinical practice, teaching and training, and future research.

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    9. Imaging human skin autograft integration with optical coherence tomography

      Imaging human skin autograft integration with optical coherence tomography

      Background: Skin autografting is a common clinical procedure for reconstructive surgery. Despite its widespread use, very few studies have been conducted to non-invasively evaluate and monitor the vascular and structural features of skin grafts. This study, therefore, aims to demonstrate the potential of optical coherence tomography (OCT) alongside OCT-based angiography (OCTA) to non-invasively image and monitor human skin graft health and integration over time. Methods: An in-house-built clinical prototype OCT system was used to acquire OCT/OCTA images from patients who underwent split-thickness skin graft surgery following severe burn damage to the skin. The OCT imaging was carried out at ...

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    10. Reflectance Confocal Microscopy, Optical Coherence Tomography, and Multiphoton Microscopy in Inflammatory Skin Disease Diagnosis

      Reflectance Confocal Microscopy, Optical Coherence Tomography, and Multiphoton Microscopy in Inflammatory Skin Disease Diagnosis

      Background and objectives: Technological advances in medicine have brought about many novel skin imaging devices. This review aims to evaluate the scientific evidence supporting the use of noninvasive optical imaging techniques to aid in the diagnosis and prognosis of inflammatory skin diseases. Study design/materials and methods: PubMed and Scopus were searched in September 2020 according to PRISMA guidelines for articles using reflectance confocal microscopy (RCM), optical coherence tomography (OCT), and multiphoton microscopy (MPM) in inflammatory skin diseases, excluding studies monitoring treatment efficacy. Results: At the time of the study, there were 66 articles that addressed the utilization of noninvasive ...

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      Mentions: UC Irvine
    11. Two-dimensional correlation (2D) method for improving the accuracy of OCT-based noninvasive blood glucose concentration (BGC) monitoring

      Two-dimensional correlation (2D) method for improving the accuracy of OCT-based noninvasive blood glucose concentration (BGC) monitoring

      The optical scattering coefficient (μ s ) in the dermis layer of human skin obtained with optical coherence tomography (OCT) has shown to have a strong correlation with the blood glucose concentration (BGC), which can be used for noninvasive BGC monitoring. Unfortunately, the nonhomogeneity in the skin may cause inaccuracies for the BGC analysis. In this paper, we propose a 2D correlation analysis method to identify 2D regions in the skin with μ s sensitive to BGC variations and only use data in these regions to calculate μ s for minimizing the inaccuracy induced by nonhomogeneity and therefore improving the accuracy of OCT-based BGC ...

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    12. Low-cost diagnostic device quickly produces 3D images of skin

      Low-cost diagnostic device quickly produces 3D images of skin

      The 3D-printed prototype is powered by a single 1.5-volt battery Nanyang Technological University When someone has a skin condition such as eczema or psoriasis, it helps to be able to see all of the tiny ridges and grooves in the affected area. That's where a portable new device comes in, which is designed to produce 3D images of skin in a matter of minutes.

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    13. NTU Singapore team develops portable device that creates 3D images of skin in 10 minutes

      NTU Singapore team develops portable device that creates 3D images of skin in 10 minutes

      NTU Singapore team develops portable device that creates 3D images of skin in 10 minutes Nanyang Technological University IMAGE: (Left to Right) Members of the NTU research team include Assistant Professor Grzegorz Lisak from NTU's School of Civil and Environmental Engineering, PhD student Yi-Heng Cheong, the study's first author... view more Credit: NTU Singapore A team from Nanyang Technological University, Singapore (NTU Singapore) has developed a portable device that produces high-resolution 3D images of human skin within 10 minutes. The team said the portable skin mapping (imaging) device could be used to assess the severity of skin conditions ...

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    14. Damae Medical DeepLive™ - Digital Optical Biopsy for Dermatology

      Damae Medical DeepLive™ - Digital Optical Biopsy for Dermatology

      DAMAE Medical develops deepLive™ medical device, the new best-in-class imaging system pairing penetration and cellular resolution in 3D. deepLive™ integrates LC-OCT (Line-field Confocal Optical Coherence Tomography) technology which provides a unique 3D imaging modality, allowing the user to switch from a histology-like vertical mode to a confocal-like horizontal mode, and to record a 3D stack of tissue volumes in situ. deepLive™ is adapted to the imaging of multiple skin conditions, promoting efficient, reassuring and non-invasive patient management. For more information, please contact us by email: info@damae-medical.com

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      Mentions: Damae Medical
    15. Assessing the Outcomes of Focused Heating of the Skin by a Long-Pulsed 1064 nm Laser with an Integrated Scanner, Infrared Thermal Guidance, and Optical Coherence Tomography

      Assessing the Outcomes of Focused Heating of the Skin by a Long-Pulsed 1064 nm Laser with an Integrated Scanner, Infrared Thermal Guidance, and Optical Coherence Tomography

      Background and Objective Long‐term benefits can be predicted by the incorporation of more intelligent systems in lasers and other devices. Such systems can produce more reliable zones of thermal injury when used in association with non‐invasive monitoring and precise laser energy delivery. The more classical endpoint of tumor destruction with radiofrequency or long‐pulsed (LP) 1064 nm laser is the non‐specific appearance of tissue graying and tissue contraction. Herein we discuss combining non‐invasive LP 1064 nm Nd:YAG treatment with the assistance of optical coherence tomography (OCT) and the forward‐looking infrared (FLIR) thermal camera while ...

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    16. Albumin‐PEG‐Based Biomaterial for Laser‐Tissue Soldering and Its Real‐Time Monitoring With Swept‐Source Optical Coherence Tomography

      Albumin‐PEG‐Based Biomaterial for Laser‐Tissue Soldering and Its Real‐Time Monitoring With Swept‐Source Optical Coherence Tomography

      Background and Objectives The study presents a noninvasive, real‐time monitoring technique for the cross‐sectional imaging of the laser‐tissue soldering process with a swept‐source optical coherence tomography (SSOCT) system. The study also aims at performing a comparative study of the laser‐tissue soldering (LTS) process using optimized compositions of albumin as solder biomaterials. Study Design/Materials and Methods The experimental study was conducted both ex vivo and in vivo to assess the superiority of the LTS process over conventional methods using a noninvasive imaging tool. In our attempt to combine the two techniques into one diagnostic tool ...

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    17. A preliminary study of post-progressive nail-art effects on in vivo nail plate using optical coherence tomography-based intensity profiling assessment

      A preliminary study of post-progressive nail-art effects on in vivo nail plate using optical coherence tomography-based intensity profiling assessment

      Nail beautification is a widely applied gender independent practice. Excessive nail beautifications and nail-arts have a direct impact on the nail structure and can cause nail disorders. Therefore, the assessment of post-progressive nail-art effects on the nail is essential to maintain optimal nail health and to avoid any undesirable disorders. In this study, in vivo nails were examined in control stage, with a nail-art stage, and after removing the nail-art stage using a 1310 nm spectral-domain optical coherence tomography (SD-OCT) system. The acquired cross-sectional OCT images were analyzed by a laboratory customized signal processing algorithm to obtain scattered intensity profiling ...

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    18. ITRI Exhibits E-Health Monitoring and Inspection Innovations at CES 2021

      ITRI Exhibits E-Health Monitoring and Inspection Innovations at CES 2021

      ITRI developed the Handheld Skin Quality Optical Coherence Tomography system to replace the conventional approach of an invasive biopsy for examining tissue underneath the skin. It is the first handheld optical coherence tomography (OCT) system that analyzes subsurface skin structures and detects collagen distribution in the dermis layer. The technology incorporates a built-in skin quality analysis model, AI, and anti-shake image capturing technology to evaluate skin quality within 10 seconds. It weighs less than 400 grams (14 ounces), allowing users to operate the device with one hand. This innovation is used for medical purposes and provides valid scientific proof for ...

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    19. Kao research opens door for better understanding of wrinkle formation

      Kao research opens door for better understanding of wrinkle formation

      Kao Corporation has announced a breakthrough in our understanding of how structural changes in the skin affect wrinkle formation. Its Biological Science Research Laboratory and Skin Care Products Research Laboratory – in collaboration with the Computational Optics Group at the University of Tsukuba – used a technique called Jones matrix-optical coherence tomography (JM-OCT) to unravel the mystery surrounding how changes at various depths result in skin wrinkling. JM-OTC is an evolution of standard OTC (a method of observing the inside of the skin without damaging it), which uses algorithms to divide up the skin into small sections by depth. A study, involving ...

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    20. Orthogonal‐polarization‐gating optical coherence tomography for human sweat ducts in vivo

      Orthogonal‐polarization‐gating optical coherence tomography for human sweat ducts in vivo

      We propose an orthogonal‐polarization‐gating optical coherence tomography (OPGOCT) for human sweat ducts in vivo . OPG‐OCT is composed of the orthogonal linearly polarized light of a sample arm individually interfering with orthogonal linearly polarized lights of the reference arms, where OPG‐OCT induces two images, one reflecting the projection intensity and the other the horizontal linear diattenuation (HLD). The results demonstrate that OPG‐OCT projection intensity could improve the image quality of sweat ducts. HLD also clearly illustrates the spiral shape of the sweat ducts. Finally, sweat ducts in intensity image are segmented by employing convolutional neural networks ...

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    21. Optical Technologies for the Improvement of Skin Cancer Diagnosis: A Review

      Optical Technologies for the Improvement of Skin Cancer Diagnosis: A Review

      The worldwide incidence of skin cancer has risen rapidly in the last decades, becoming one in three cancers nowadays. Currently, a person has a 4% chance of developing melanoma, the most aggressive form of skin cancer, which causes the greatest number of deaths. In the context of increasing incidence and mortality, skin cancer bears a heavy health and economic burden. Nevertheless, the 5-year survival rate for people with skin cancer significantly improves if the disease is detected and treated early. Accordingly, large research efforts have been devoted to achieve early detection and better understanding of the disease, with the aim ...

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    22. Orthogonal-polarization-gating optical coherence tomography for human sweat ducts in vivo

      Orthogonal-polarization-gating optical coherence tomography for human sweat ducts in vivo

      We propose an orthogonal-polarization-gating optical coherence tomography (OPGOCT) for human sweat ducts in vivo. OPG-OCT is composed of the orthogonal linearly polarized light of a sample arm individually interfering with orthogonal linearly polarized lights of the reference arms, where OPG-OCT induces two images, one reflecting the projection intensity and the other the horizontal linear diattenuation (HLD). The results demonstrate that OPG-OCT projection intensity could improve the image quality of sweat ducts. HLD also clearly illustrates the spiral shape of the sweat ducts. Finally, sweat ducts in intensity image are segmented by employing convolutional neural networks (CNN). The proportions of left-handed ...

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    23. Efficacy of a Topical Product Containing Purified Omental Lipids and Three Anti-Itching Compounds in the Treatment of Chronic Pruritus/Prurigo Nodularis in Elderly Subjects: A Prospective, Assessor-Blinded, 4-Week Trial with Transepidermal Water Loss and

      Efficacy of a Topical Product Containing Purified Omental Lipids and Three Anti-Itching Compounds in the Treatment of Chronic Pruritus/Prurigo Nodularis in Elderly Subjects: A Prospective, Assessor-Blinded, 4-Week Trial with Transepidermal Water Loss and

      Purpose: To investigate the efficacy of a cream containing purified omental lipids 10% and three anti-itching substances (polidocanol/stimutex/palmitoylethanolamine) in elderly subjects with chronic pruritus/prurigo nodularis (CP/CPN). Patients and Methods: Thirty-five subjects (6 men; mean age 67± 4 years) with CP/CPN were enrolled in a prospective, assessor-blinded, 4-week study. The cream was applied twice daily in the most affected body area. The primary endpoints were the evolution of the 10-cm visual analogue itch severity scale (VAS) and the 4-point verbal itching rating scale (VRS) (from 0 to 3). Secondary endpoints were the evolution of optical coherence ...

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