1. Articles in category: Dermatology

    1-24 of 659 1 2 3 4 ... 26 27 28 »
    1. Morphomechanics of dermis-A method for non-destructive testing of collagenous tissues

      Morphomechanics of dermis-A method for non-destructive testing of collagenous tissues

      Background Collagenous tissues store, transmit and dissipate elastic energy during mechanical deformation. In skin, mechanical energy is stored during loading and then is dissipated, which protects skin from mechanical failure. Thus, energy storage (elastic properties) and dissipation (viscous properties) are important characteristics of extracellular matrices (ECMs) that support the cyclic loading of ECMs without tissue failure. Methods Uniaxial stress-strain measurements on decellularized human dermis have been made and compared to results of a non-destructive technique involving optical coherence tomography (OCT) combined with vibrational analysis. In addition, Poisson's ratio has been determined for tensile deformation of decellularized dermis. Results The ...

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    2. Melanoma diagnosis may be a pitfall for optical coherence tomography assessment of equivocal amelanotic or hypomelanotic skin lesions

      Melanoma diagnosis may be a pitfall for optical coherence tomography assessment of equivocal amelanotic or hypomelanotic skin lesions

      melanotic and hypomelanotic skin lesions can be difficult to diagnose clinically and dermoscopically. 1-3 Evidence is emerging that optical coherence tomography (OCT) can detect superficial basal cell carcinoma (sBCC) with good sensitivity (79-95.7%) and specificity (75.3-96%). 4 Given that sBCC is a common problem 4 , and that it may be treated noninvasively 5 , the potential benefits from using OCT as an adjunct to clinical diagnosis are high. However, if OCT is used without histopathological confirmation in this setting, there is a risk that more clinically aggressive malignant pathology, such as amelanotic /hypomelanotic melanoma (AHM), may be misdiagnosed and ...

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    3. In vivo label-free lymphangiography of cutaneous lymphatic vessels in human burn scars using optical coherence tomography

      In vivo label-free lymphangiography of cutaneous lymphatic vessels in human burn scars using optical coherence tomography

      We present an automated, label-free method for lymphangiography of cutaneous lymphatic vessels in humans in vivo using optical coherence tomography (OCT). This method corrects for the variation in OCT signal due to the confocal function and sensitivity fall-off of a spectral-domain OCT system and utilizes a single-scattering model to compensate for A-scan signal attenuation to enable reliable thresholding of lymphatic vessels. A segment-joining algorithm is then incorporated into the method to mitigate partial-volume effects with small vessels. The lymphatic vessel images are augmented with images of the blood vessel network, acquired from the speckle decorrelation with additional weighting to differentiate ...

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    4. Commentary on the Diagnostic Utility of Non-invasive Imaging Devices for Field Cancerization

      Commentary on the Diagnostic Utility of Non-invasive Imaging Devices for Field Cancerization

      In this issue of Experimental Dermatology , Marneffe and collegues present a practical algorithmic guide to differentiating actinic keratosis (AK) from normal skin and squamous cell carcinoma (SCC) using high-definition optical coherence tomography (HD-OCT), outlining steps and markers to guide both novice and more experienced skin cancer experts (1).

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    5. Update on advanced basal cell carcinoma diagnosis and treatment

      Update on advanced basal cell carcinoma diagnosis and treatment

      Basal cell carcinoma (BCC) is the most commonly diagnosed cancer and the most common skin cancer in the world 1-5 . Despite increased insight on skin cancer risk factors, including excessive sun exposure and indoor tanning, the incidence of skin cancer continues to rise worldwide, particularly in younger populations 6 . In a recent study, it was estimated that more than four million cases are diagnosed annually in the United States alone 6 . Given the widespread prevalence of this disease, there is a substantial impact on overall patient morbidity and quality of life 7-9 . Similarly, medical treatment for skin cancer accounts for ...

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    6. The use of transdermal optical coherence tomography to image the superficial temporal arteries

      The use of transdermal optical coherence tomography to image the superficial temporal arteries

      Purpose The diagnosis of Giant Cell Arteritis (GCA) is an area of major challenge. This is the first reported use of the directed use of transdermal optical coherence tomography (OCT) to image the superficial temporal artery (STA). Methods This proof of concept study used a commercially available transdermal OCT instrument to identify and image the STA in eight patients (suspected GCA, confirmed GCA, and in healthy controls). Three cases are presented to demonstrate the preliminary imaging findings. Results In all eight cases the STA was identified. Imaging findings from three cases are presented. A hyper-reflective signal was seen, which distinguishes ...

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    7. Performance analysis of a Hybrid fingerprint extracted from optical coherence tomography fingertip scans

      Performance analysis of a Hybrid fingerprint extracted from optical coherence tomography fingertip scans

      The Hybrid fingerprint is a local-quality-specific blend of the surface and internal fingerprints, extracted from optical coherence tomography scans. Owing to its origin, and the manner in which it is obtained, the Hybrid fingerprint is a high-quality and secure fingerprint acquisition solution. This research entails a detailed description of the Hybrid fingerprint, the techniques involved to produce it, and a performance analysis of it. A dataset of 282 fingertip scans was established. Two recognised minutiae extraction and fingerprint matching algorithms were applied to assess the performance of the Hybrid fingerprint. The best equal error rate measured was 1.25%. NIST ...

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      Mentions: Ann Singh
    8. Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study

      Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study

      Noninvasive techniques for nail imaging would be useful for confirming diagnosis and monitoring treatment response at the microscopic level in patients with nail psoriasis. However, the use of ultrasound and high-resolution magnetic resonance imaging in nail evaluation is limited. Optical coherence tomography (OCT) produces high-resolution images of transversal tissue sections and represents an optimal approach to the study of the nail. This study used a multibeam OCT instrument to produce speckled variance OCT (SV-OCT) blood-flow images, which were used to measure the degree of change over successive scans. Nail changes, inflammation and response to therapy were evaluated in a 75-year-old ...

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    9. Optical Coherence Tomography for Skin Cancer Screening

      Optical Coherence Tomography for Skin Cancer Screening

      Skin cancer is the most common malignancy worldwide. Non-Melanoma Skin Cancers (NMSC), including Basal Cell Carcinomas (BCC) and Squamous Cell Carcinomas (SCC) are the most common, constituting around 80 percent of all skin cancers [1]. It is estimated that approximately 3.5 million new cases of NMSC occur every year in the United States, exceeding that of all other cancers combined [2-5]. In contrast, melanoma accounts for less than one percent of skin cancer cases, but the vast majority of skin cancer deaths [6]. The incidence of NMSC rises rapidly with patient age and has been increasing annually by between ...

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    10. Vascular Features of Nail Psoriasis Using Dynamic Optical Coherence Tomography

      Vascular Features of Nail Psoriasis Using Dynamic Optical Coherence Tomography

      Background: Nail psoriasis is a painful and disfiguring nail disease that often leads to invasive biopsies. Dermoscopy of the hyponychium can be useful in the diagnosis showing twisted coiled vessels. Structural features of nail psoriasis have been described with optical coherence tomography (OCT). Objectives: To investigate vascular features of nail psoriasis using dynamic OCT. Methods: This was an observational, prospective, controlled study in which psoriasis patients with psoriatic nail changes and healthy control patients underwent OCT imaging of the distal nail plate and proximal nail fold. Vertical and horizontal OCT images were analyzed to describe structural and vascular features and ...

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    11. Morphological analysis of the growth stages of in-vivo mouse hair follicles by using optical coherence tomography

      Morphological analysis of the growth stages of in-vivo mouse hair follicles by using optical coherence tomography

      Swept-source optical coherence tomography (SS-OCT), a bio-photonic imaging modality, was used to demonstrate an initial feasibility experiment for detecting morphological variations of in-vivo mouse hair follicles for the anagen and the telogen growth stages. Two C57BL/6 adult male mice, one undergoing the anagen stage and the other undergoing the telogen stage of the hair follicle growth cycle, were selected for the experiment. The OCT cross-sectional images of mice skin were acquired in-vivo within an interval of 15 days, and the observed morphological changes were analyzed. The micro-structural features of mice skin on the 15th experimental day were further compared ...

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      Mentions: Jeehyun Kim
    12. The Use of Noninvasive Optical Coherence Tomography to Monitor the Treatment Progress of Vismodegib and Imiquimod 5% Cream in a Transplant Patient with Advanced Basal Cell Carcinoma of the Nose

      The Use of Noninvasive Optical Coherence Tomography to Monitor the Treatment Progress of Vismodegib and Imiquimod 5% Cream in a Transplant Patient with Advanced Basal Cell Carcinoma of the Nose

      Immunosuppressed transplant recipients have increased risk for the development of basal cell carcinoma skin cancers. While oral vismodegib therapy has been successful in treating locally advanced basal cell tumors, few studies document its use and efficacy in organ transplant patients. In this immunocompromised population, topical imiquimod 5% cream has been shown to be an effective and well-tolerated option for superficial and nodular basal cell carcinomas. To the authors' knowledge, no data documents the use of optical coherence tomography, a noninvasive imaging technique, to monitor progress of such combined therapies on in vivo skin. The authors report the successful treatment of ...

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    13. New fingerprinting technology will aid law enforcement

      New fingerprinting technology will aid law enforcement

      The CSIR has unveiled a new-generation fingerprint sensing technology to aid in law enforcement and forensic areas. The device, funded by the Department of Science and Technology, is the first prototype, and the next step will be to reduce its size to a hand-held gadget and prepare it for commercialisation. The system is capable of exploring the internal features of an object. Laser scientist Ann Sigh said optical coherence tomography used light to capture in 3D the finest of details from biological tissue and could be likened to ultrasound but using light. She said it was important to note that ...

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    14. Paws, print, detect, arrest

      Paws, print, detect, arrest

      South African researchers revealed a prototype fingerprint-sensing device at the CSIR in Pretoria yesterday.  The new technology, the first of its kind in Africa, will be linked to police and Home Affairs fingerprint databases. Through the use of lasers it processes fingerprints taken from crime scenes and from people in under three seconds. Researchers are now hard at work to make the device portable. It is currently the size of a big shoebox and can be fitted to a police vehicle. Co-designer Ameeth Sharman said that in the initial design the technology had been geared towards the collection of "live ...

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    15. Compact Imaging to Demonstrate Sub-dermal Fingerprint for Presentation Attack Detection At GIS2016 in Tampa

      Compact Imaging to Demonstrate Sub-dermal Fingerprint for  Presentation Attack Detection At GIS2016 in Tampa

      Compact Imaging, Inc., a Silicon Valley company developing small, low-cost optical sensors for the rapidly growing biometric security, personal health monitoring and non-destructive testing (NDT) markets, today announced that it will demonstrate its MRO™ subsurface scanning technology at the Global Identity Summit 2016 (GIS2016), Sept. 19-22, in Tampa. Compact Imaging's breakthrough MRO™ (Multiple Reference OCT) technology brings non-invasive OCT (optical coherence tomography) depth scanning to high volume field applications that require small size and low cost, such as biometric collection systems. Previously, OCT had been limited by its large size, high cost and extreme complexity in clinical and laboratory ...

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    16. Master/slave optical coherence tomography imaging of eyelid basal cell carcinoma

      Master/slave optical coherence tomography imaging of eyelid basal cell carcinoma

      Optical coherence tomography (OCT) is fast emerging as an additional non-interventional modality for skin tumor detection and diagnosis. A master/slave flying spot OCT configuration was assembled to detect periocular basal cell carcinomas (BCC). A swept source at 1300 nm and sweeping speed of 50 kHz were used. A three-step process was involved. First, 384 channeled spectra using a mirror were stored for 384 optical path differences at the master stage. Then, the stored channeled spectra (masks) were correlated with the channeled spectrum from the BCC tissue to produce 384 en face OCT images ( 200 × 200 pixels) for the optical ...

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    17. Classification of basal cell carcinoma in human skin using machine learning and quantitative features captured by polarization sensitive optical coherence tomography

      Classification of basal cell carcinoma in human skin using machine learning and quantitative features captured by polarization sensitive optical coherence tomography

      We report the first fully automated detection of basal cell carcinoma (BCC), the most commonly occurring type of skin cancer, in human skin using polarization-sensitive optical coherence tomography (PS-OCT). Our proposed automated procedure entails building a machine-learning based classifier by extracting image features from the two complementary image contrasts offered by PS-OCT, intensity and phase retardation (PR), and selecting a subset of features that yields a classifier with the highest accuracy. Our classifier achieved 95.4% sensitivity and specificity, validated by leave-one-patient-out cross validation (LOPOCV), in detecting BCC in human skin samples collected from 42 patients. Moreover, we show the ...

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    18. Optical Coherence Tomography for Skin Cancer

      Optical Coherence Tomography for Skin Cancer

      Skin cancer is the most common malignancy worldwide, and non-melanoma skin cancers (NMSC) in particular, including basal cell carcinomas (BCC) and squamous cell carcinomas, constitute around 80 percent of all skin cancers. It is estimated that approximately 3.5 million new cases of NMSC occur every year in the U.S., exceeding that of all other cancers combined. Despite the high prevalence of NMSC, they can be effectively treated and cured with low recurrence when detected at an early stage. BCCs are known to be slow growing and rarely metastasize to other parts of the body; however, if left untreated ...

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    19. Morphologic features of basal cell carcinoma using the en-face mode in frequency domain optical coherence tomography

      Morphologic features of basal cell carcinoma using the en-face mode in frequency domain optical coherence tomography

      Background Optical coherence tomography (OCT) has become a valuable non-invasive tool in the in vivo diagnosis of non-melanoma skin cancer, especially of basal cell carcinoma (BCC). Due to an updated software-supported algorithm, a new en-face mode – similar to the horizontal en-face mode in high-definition OCT and reflectance confocal microscopy – surface-parallel imaging is possible which, in combination with the established slice mode of frequency domain (FD-)OCT, may offer additional information in the diagnosis of BCC. Objectives To define characteristic morphologic features of BCC using the new en-face mode in addition to the conventional cross-sectional imaging mode for three-dimensional imaging of ...

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    20. Dermoscopy, confocal microscopy and optical coherence tomography for the diagnosis of bedbug infestation

      Dermoscopy, confocal microscopy and optical coherence tomography for the diagnosis of bedbug infestation

      Letter to the editor: A 33 year-old woman suffering from rosacea presented with outbreaks of itchy plaques on her face and limbs that curiously improved when she was far from home during summer holidays (Fig. 1). Dermoscopy (FotoFinder Systems GmbH, Bad Birnbach, Germany) showed petechiae (Fig. 2A) and reflectance confocal microscopy (RCM; Vivascope 3000 ® , Caliber, New York, USA, distributed in Europe by MAVIG GmbH, München, Germany) showed intraepidermal vesicles (Fig. 2B) suggesting parasite bites. RCM found Demodex folliculorum (Fig. 2C) that could have been responsible for rosacea. However, a careful examination with dermoscopy identified a brown oval-shaped wingless insect ...

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      Mentions: AGFA Healthcare
    21. Diagnostic accuracy of optical coherence tomography in actinic keratosis and basal cell carcinoma

      Diagnostic accuracy of optical coherence tomography in actinic keratosis and basal cell carcinoma

      Background Early diagnosis of non-melanoma skin cancer (NMSC) is potentially possible using optical coherence tomography (OCT) which provides non-invasive, real-time images of skin with micrometre resolution and an imaging depth of up to 2 mm. OCT technology for skin imaging has undergone significant developments, improving image quality substantially. The diagnostic accuracy of any method is influenced by continuous technological development making it necessary to regularly re-evaluate methods. Objective The objective of this study is to estimate the diagnostic accuracy of OCT in basal cell carcinomas (BCC) and actinic keratosis (AK) as well as differentiating these lesions from normal skin. Methods ...

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    1-24 of 659 1 2 3 4 ... 26 27 28 »
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