1. Articles in category: Dermatology

    1-24 of 1164 1 2 3 4 ... 47 48 49 »
    1. AI Quantitative Coronary Angiography Versus Optical Coherent Tomography Guidance for Coronary Stent Implantation

      AI Quantitative Coronary Angiography Versus Optical Coherent Tomography Guidance for Coronary Stent Implantation

      This original clinical research project utilizes cutting-edge medical imaging technologies for diagnosis of pigmented skin tumours, combined for the first time in Denmark, with molecular RNA and lipid analysis of superficial tumours cells. The scanning technologies are reflectance confocal microscopy (RCM), which is a microscope applied directly to the skin surface, and photoacoustic imaging, also termed multispectral optoacoustic imaging (MSOT), which is an imaging technology actually listening to the skin for immediate bedside diagnosis of pigmented skin tumors. The hypothesis is that treatment guided by diagnostic bedside skin scanning, combined with tumour tape-stripping and RNA and lipid analysis can increase ...

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    2. Patient Preference for Optical Coherence Tomography versus Punch Biopsy as Diagnostic Strategy for Diagnosis of Basal Cell Carcinoma: A Labelled Discrete Choice Experiment

      Patient Preference for Optical Coherence Tomography versus Punch Biopsy as Diagnostic Strategy for Diagnosis of Basal Cell Carcinoma: A Labelled Discrete Choice Experiment

      Non-invasive technologies, such as optical coherence tomography (OCT), are increasingly available for diagnosis of basal cell carcinoma (BCC), and might partly replace a punch biopsy, which is considered the current gold standard (1, 2). To examine patient preferences for OCT or punch biopsy as diagnostic strategy for BCC, a discrete choice experiment (DCE) was performed alongside a clinical trial (ClinicalTrials.gov number, NCT03848078). The selection of attributes and associated levels ( Table I ) was based on literature review and expert opinion (3–8)

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    3. Transforming the treatment of psoriasis to the 21st century: Detecting subclinical therapeutic response to secukinumab using optical coherence tomography as a prognostic indicator

      Transforming the treatment of psoriasis to the 21st century: Detecting subclinical therapeutic response to secukinumab using optical coherence tomography as a prognostic indicator

      Background: Optical coherence tomography (OCT) is a noninvasive imaging device that scans the skin up to 2 mm in depth. OCT can capture real-time epidermal thickness (ET) measurements and detect subclinical changes in inflammatory skin diseases like eczema and psoriasis. © 2022 Wiley Periodicals LLC. Objective: To determine if measuring ET with OCT can detect a subclinical therapeutic response in psoriasis treated with the biological therapy, secukinumab (an IL-17A antagonist). Design: Phase IV, single-center, open-label, and single-arm study. Participants: Twenty-six consecutive patients with moderate to severe plaque psoriasis. Measurements: Clinical, dermoscopic, and OCT images were obtained at each visit. The clinician ...

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    4. Examination of Subungual Hematomas and Subungual Melanocytic Lesions by Using Optical Coherence Tomography and Dermoscopy

      Examination of Subungual Hematomas and Subungual Melanocytic Lesions by Using Optical Coherence Tomography and Dermoscopy

      Introduction: Examination of subungual pigmented lesions is sometimes a diagnostic challenge for clinicians. Objectives: The study was aimed to investigate characteristic patterns in optical coherence tomography (OCT) of subungual hematomas and determine distinctive features that can differentiate them from subungual melanocytic lesions. Methods: VivoSight® (Michelson Diagnostics, Maidstone, UK) was used to examine 71 subungual hematomas and 11 subungual melanocytic lesions in 69 patients (18 female and 51 male patients). Results: On OCT, bleeding was related to sharply defined black sickle-shaped ( p < 0.001) or globular regions (not significant [ns]) with a hyperreflective margin (0.002), a grey center (0.013 ...

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    5. The Advanced Applications for Optical Coherence Tomography in Skin Imaging (Thesis)

      The Advanced Applications for Optical Coherence Tomography in Skin Imaging (Thesis)

      Optical coherence tomography (OCT), based on low coherent interferometry, is an FDAapproved non-invasive imaging modality. It uses a low coherent near-infrared laser around the wavelength of 1300 nm [1]. OCT has been widely used in ophthalmology to assess retina thickness and anatomical changes. In 1997, this technology was tested to image the cross-section of human skin in vivo, and it was able to visualize different skin layers and skin appendages [2]. Although, OCT has great potential in monitoring skin morphologic changes, skin cancer diagnosis, and tumor margin assessment [3], it is not well recognized and adopted by many dermatologists. Therefore ...

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    6. Imaging-photoplethysmography-guided optical microangiography

      Imaging-photoplethysmography-guided optical microangiography

      We report a method to image facial cutaneous microvascular perfusion using wide-field imaging photoplethysmography (iPPG) and handheld swept-source optical coherence tomography (OCT). The iPPG system employs a 16-bit-depth camera to provide a 2D wide-field blood pulsation map that is then used as a positioning guidance for OCT imaging of cutaneous microvasculature. We show the results from iPPG and OCT to demonstrate the ability of guided imaging of cutaneous microvasculature, which is potentially useful for the assessment of skin conditions in dermatology and cosmetology.

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    7. Research Techniques Made Simple: Emerging Imaging Technologies for Noninvasive Optical Biopsy of Human Skin

      Research Techniques Made Simple: Emerging Imaging Technologies for Noninvasive Optical Biopsy of Human Skin

      Over the past few years, high-resolution optical imaging technologies such as optical coherence tomography (OCT), reflectance confocal microscopy (RCM), and multiphoton microscopy (MPM) have advanced significantly as new methodologies for clinical research and for real-time detection, diagnosis, and therapy monitoring of skin diseases. Implementation of these technologies into clinical research and practice requires clinicians to have an understanding of their capabilities, benefits, and limitations. This concise review provides insights on the application of OCT, RCM, and MPM for clinical skin imaging through images acquired in vivo from the same lesions. The presented data are limited to pigmented lesions and basal ...

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    8. Ex-vivo Examination of Excisions of Skin Tumors by Confocal Optical Coherence Tomography (LC-OCT) With Integrated Dermoscopy and Comparison With Histology (DERMOCTAV)

      Ex-vivo Examination of Excisions of Skin Tumors by Confocal Optical Coherence Tomography (LC-OCT) With Integrated Dermoscopy and Comparison With Histology (DERMOCTAV)

      There are mainly 3 types of skin cancer: melanoma, basal cell carcinoma and squamous cell carcinoma. The diagnosis of skin cancers is now based on anatomo-pathological evidence. However, given the progress made, imaging is a technique that now has a full role in the diagnosis of these pathologies. This is particularly the case of confocal optical coherence tomography (LC-OCT), which is a recent imaging technique that has proven itself in ophthalmology with the obtaining of precise images of the retina. LC-OCT can be applied in dermatology according to the following principle: the low intensity laser beam delivered by the LC-OCT ...

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      Mentions: Damae Medical
    9. Dermoscopy, Reflectance Confocal Microscopy and Optical Coherence Tomography Features of Acne: A Systematic Review

      Dermoscopy, Reflectance Confocal Microscopy and Optical Coherence Tomography Features of Acne: A Systematic Review

      Noninvasive imaging techniques have recently outlined precise microscopic features of acne elementary lesions and accurate quantifications for disease severity staging and therapeutical efficacy follow-up. The aim of this review is to systematically describe current applications of dermoscopy, reflectance confocal microscopy (RCM), and optical coherence tomography (OCT) in acne vulgaris assessment and management. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. We included studies conducted on human subjects with elementary lesions of acne vulgaris, reporting assessment of the lesions with dermoscopy, RCM, and/or OCT. At present there are few large studies regarding acne and ...

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    10. New Imaging Procedures and Therapeutic Approach in Basal Cell Carcinoma Management

      New Imaging Procedures and Therapeutic Approach in Basal Cell Carcinoma Management

      The aim of this study is to show that the Nd:YAG laser could be a promising alternative treatment option in the management of low-risk basal cell carcinomas with similar high efficacy rates to surgery, and low recurrence rates evaluated over a time period of one year. Reflectance confocal microscopy, optical coherence tomography and clinical examination are used prior to confirm the clinical diagnosis of the basal cell carcinoma and for premargination of the tumor. The optical coherence tomography will also be used post treatment to confirm clearance of the basal cell carcinoma and to monitor treatment response

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    11. Epidermal thickness in healthy humans: A systematic review and meta-analysis

      Epidermal thickness in healthy humans: A systematic review and meta-analysis

      Several skin diseases are characterised by epidermal alterations affecting epidermal thickness. Reference values of epidermal thickness in healthy humans and knowledge of possible differences regarding age, sex, skin phototype, and ethnic origin are essential in research and in clinical practice. The objectives of this systematic review were to provide epidermal thickness reference values for healthy human skin and describe possible effects of measurement methods, age, sex, ethnic origin, and skin phototype. A combined search in the databases Medline and Embase, and other sources was conducted. Searches covered a period from 1946 to 3 rd June 2020. Included studies were primary ...

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    12. Co-localized line-field confocal optical coherence tomography and confocal Raman microspectroscopy for three-dimensional high-resolution morphological and molecular characterization of skin tissues ex vivo

      Co-localized line-field confocal optical coherence tomography and confocal Raman microspectroscopy for three-dimensional high-resolution morphological and molecular characterization of skin tissues ex vivo

      Line-field confocal optical coherence tomography (LC-OCT) is an optical modality that provides three-dimensional (3D) images of the skin at cellular resolution. Confocal Raman microspectroscopy (CRM) is a label-free optical technique that can provide point measurement of the molecular content of the skin. This work presents a method to co-localize LC-OCT and CRM acquisitions for morpho-molecular analysis of ex vivo skin tissues at cellular level. The co-localization method allows acquisition of Raman spectra at specific locations in a sample identified from a 3D LC-OCT image, with an accuracy of ± 20 µm. The method was applied to the characterization of tattooed skin ...

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    13. Imaging of the Nail Unit in Psoriatic Patients – a Systematic Scoping Review of Techniques and Terminology

      Imaging of the Nail Unit in Psoriatic Patients – a Systematic Scoping Review of Techniques and Terminology

      Background The growing interest in the visualization of psoriatic nail unit changes has led to the discovery of an abundance of image characteristics across various modalities. Objective To identify techniques for non-invasive imaging of nail unit structures in psoriatic patients and review extracted image features to unify the diverse terminology. Methods For this systematic scoping review, we included studies available on PubMed and Embase, independently extracted image characteristics, and semantically grouped the identified features to suggest a preferred terminology for each technique. Results After screening 753 studies, 67 articles on the visualization of clinical and subclinical psoriatic changes in the ...

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    14. Blood Vessel Dilation and Inflammatory Associated Hypervascularization Demonstrated in Nodular Inflammatory Lesions of Hidradenitis Suppurativa

      Blood Vessel Dilation and Inflammatory Associated Hypervascularization Demonstrated in Nodular Inflammatory Lesions of Hidradenitis Suppurativa

      In a recent study published in Experimental Dermatology , nodular inflammatory lesions in hidradenitis suppurativa (HS) examined using dynamic optical coherence tomography (D-OCT) demonstrate blood vessel dilation and inflammatory associated hypervascularization. Researchers aimed to assess and describe D-OCT morphological features of nodular inflammatory HS lesions and to determine whether different D-OCT features are associated with a distinct phenotype of the disease in a retrospective case-control study of patients with HS and matched controls. The study was performed at the dermatology department of the University of Modena and Reggio Emilia between January 2018 and June 2021. Standardized clinical pictures and D-OCT images ...

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    15. In Vivo Identification of Skin Photodamage Induced by Fractional CO2 and Picosecond Nd:YAG Lasers with Optical Coherence Tomography

      In Vivo Identification of Skin Photodamage Induced by Fractional CO2 and Picosecond Nd:YAG Lasers with Optical Coherence Tomography

      Fractional laser treatment is commonly used for dermatological applications, enabling effective induction of collagen regeneration and significantly reducing recovery time. However, it is challenging to observe laser-induced photodamage beneath the tissue surface in vivo, making the non-invasive evaluation of treatment outcomes difficult. For in vivo real-time study of the photodamage induced by fractional pulsed CO 2 and Nd:YAG lasers commonly utilized for clinical therapy, a portable spectral-domain optical coherence tomography (SD-OCT) system was implemented for clinical studies. The photodamage caused by two lasers, including photothermal and photoacoustic effects, was investigated using OCT, together with the correlation between photodamage and ...

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    16. A Study on Radiation Therapy Guided by the Reflectance Confocal Microscopy (RCM)/Optimal Coherence Tomography (OCT) Device in People With Basal Cell Carcinoma

      A Study on Radiation Therapy Guided by the Reflectance Confocal Microscopy (RCM)/Optimal Coherence Tomography (OCT) Device in People With Basal Cell Carcinoma

      The purpose of this study is to find out if radiation therapy (RT) guided by the new reflectance confocal microscopy (RCM)/optimal coherence tomography (OCT) device is an effective treatment for basal cell carcinoma (BCC). The researchers will also look at the side effects from RT guided by the RCM/OCT device. In addition, will determine the quality of life before and after treatment by having the participant fill out questionnaires.

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    17. Automated epidermal thickness quantification of in vitro human skin equivalents using optical coherence tomography

      Automated epidermal thickness quantification of in vitro human skin equivalents using optical coherence tomography

      Human skin equivalents (HSEs) are in vitro models of human skin. They are used to study skin development, diseases, wound healing and toxicity. The gold standard of analysis is histological sectioning, which both limits three-dimensional assessment of the tissue and prevents live culture monitoring. Optical coherence tomography (OCT) has previously been used to visualize in vivo human skin and in vitro models. OCT is noninvasive and enables real-time volumetric analysis of HSEs. The techniques presented here demonstrate the use of OCT imaging to track HSE epidermal thickness over 8 weeks of culture and improve upon previous processing of OCT images ...

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      Mentions: UC Riverside
    18. Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains: Multivariate Analysis of Clinical Efficacy and Optical Coherence Tomography Appearance

      Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains: Multivariate Analysis of Clinical Efficacy and Optical Coherence Tomography Appearance

      Background: Hemoporfin-mediated photodynamic therapy (HMME-PDT) is reported to be effective and safe for port-wine stains (PWS). However, its efficacy is influenced by several factors and there is no appropriate method to evaluate efficacy so far. Therefore, this study explored the clinical efficacy of HMME-PDT for PWS on the face and neck and the feasibility of evaluating treatment potency with optical coherence tomography (OCT). Methods: A total of 211 PWS patients subjected to HMME-PDT were recruited for study and correlations of therapeutic effect with treatment sessions, age, gender, lesion distribution and treatment history analyzed. OCT was utilized for quantitative analysis of ...

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    19. High resolution imaging and quantification of the nailfold microvasculature using optical coherence tomography angiography (OCTA) and capillaroscopy

      High resolution imaging and quantification of the nailfold microvasculature using optical coherence tomography angiography (OCTA) and capillaroscopy

      Background: A wide range of diseases, such as systemic sclerosis, can be diagnosed by imaging the nailfold microcirculation, which is conventionally performed using capillaroscopy. This study applied optical coherence tomography angiography (OCTA) as a novel high resolution imaging method for the qualitative and quantitative assessment of the nailfold microvasculature, and compared OCTA imaging with capillaroscopy. Methods: For qualitative assessment, high resolution OCTA imaging was used to achieve images that contained a wide field of view of the nailfold microvasculature through mosaic scanning. OCTA imaging was also used to observe the characteristic changes in the microvasculature under external compression of the ...

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    20. Probing elastic anisotropy of human skin in vivo with light using non-contact acoustic micro-tapping OCE and polarization sensitive OCT

      Probing elastic anisotropy of human skin in vivo with light using non-contact acoustic micro-tapping OCE and polarization sensitive OCT

      Skin broadly protects the human body from undesired factors such as ultraviolet radiation and abrasion and helps conserve body temperature and hydration. Skin’s elasticity and its level of anisotropy are key to its aesthetics and function. Currently, however, treatment success is often speculative and subjective, and is rarely based on skin’s elastic properties because there is no fast and accurate non-contact method for imaging of skin’s elasticity.

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    21. The Advanced Applications for Optical Coherence Tomography in Skin Imaging (Thesis)

      The Advanced Applications for Optical Coherence Tomography in Skin Imaging (Thesis)

      I NTRODUCTION Optical coherence tomography (OCT), based on low coherent interferometry, is an FDA - approved non - invasive imaging modality. It uses a low coherent near - infrared laser around the wavelength of 1300 nm [1] . OCT has been widely used in ophthalmology to assess r etina thickness and anatomical changes. In 1997, this technology was tested to image the cross - section of human skin in vivo , and it was able to visuali ze different skin layer s and skin appendages [2] . Although , OCT has great potential in monitoring skin morphologic changes, skin cancer diagnosis , and tumor margin assessment [3] , i t ...

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    22. Line-Field Confocal Optical Coherence Tomography: A New Tool for the Differentiation between Nevi and Melanomas?

      Line-Field Confocal Optical Coherence Tomography: A New Tool for the Differentiation between Nevi and Melanomas?

      Until now, the clinical differentiation between a nevus and a melanoma is still challenging in some cases. Line-field confocal optical coherence tomography (LC-OCT) is a new tool with the aim to change that. The aim of the study was to evaluate LC-OCT for the discrimination between nevi and melanomas. A total of 84 melanocytic lesions were examined with LC-OCT and 36 were also imaged with RCM. The observers recorded the diagnoses, and the presence or absence of the 18 most common imaging parameters for melanocytic lesions, nevi, and melanomas in the LC-OCT images. Their confidence in diagnosis and the image ...

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    23. Monitoring Response to Therapy in Atopic Dermatitis Patients Treated With Dupilumab Using Noninvasive Reflectance Confocal Microscopy and Optical Coherence Tomography

      Monitoring Response to Therapy in Atopic Dermatitis Patients Treated With Dupilumab Using Noninvasive Reflectance Confocal Microscopy and Optical Coherence Tomography

      Participating in this research will allow the subject to undergo a noninvasive imaging alternative to conventional monitoring in response to a biologic. Normally, subjects would undergo a clinical examination, serial photography, and possible biopsies to assess the progression of the disease. This study will get rid of the need for a biopsy but will require multiple scans with non-invasive imaging. This research examines a new approach to monitoring response to a biologic drug used for atopic dermatitis, and can also, be used to grade disease severity without the need for a biopsy.

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