1. Articles in category: Dermatology

    1-24 of 472 1 2 3 4 ... 18 19 20 »
    1. Three-Dimensional High Definition-Optical Coherence Tomography Image Acquisition Procedure For Basal Cell Carcinoma

      Three-Dimensional High Definition-Optical Coherence Tomography Image Acquisition Procedure For Basal Cell Carcinoma

      We read with great interest the paper "Histopathological correlates of basal cell carcinoma in slice and en-face imaging modes of high-definition optical coherence tomography" by Gambichler et al. Optical Coherence Tomography (OCT) seems an interesting technology to study skin tumours. In particular it has been found helpful for basal cell carcinoma (BCC) diagnosis in several investigations. 

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    2. Great EADV meeting in Amsterdam | Eduardo Margallo

      Great EADV meeting in Amsterdam | Eduardo Margallo

      MedLumics demonstrated NITID™, a new skin imaging solution providing simultaneous Optical Coherence Tomography and video dermoscopy in a hand-held battery-operated system. This revolution in skin care, designed for the daily dermatology practice, will be commercially available soon.

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    3. Michelson Diagnostics launches new improved version of VivoSight OCT scanner with Micro-Camera to aid skin cancer diagnosis

      Michelson Diagnostics launches new improved version of VivoSight OCT scanner with Micro-Camera to aid skin cancer diagnosis

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, announces the launch of a new improved version of its innovative VivoSight OCT scanner at the European Academy of Dermatology and Venereology (EADV) Annual Meeting, 8-12 October, Amsterdam. The VivoSight scanner probe is now equipped with a new Micro Camera that provides the user with a real-time, colour, magnified view of the skin lesion being scanned. The new Micro Camera image is shown simultaneously with the vertical and en face OCT images, making the VivoSight scanner the only dermatological clinical OCT device to provide ...

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    4. Ex-vivo multi-modal microscopy of healthy skin

      Ex-vivo multi-modal microscopy of healthy skin

      The thorough characterization of skin samples is a critical step in investigating dermatological diseases. The combination of depth-sensitive anatomical imaging with molecular imaging has the potential to provide vast information about the skin. In this proof-of-concept work we present high-resolution mosaic images of skin biopsies using Optical Coherence Tomography (OCT) manually co-registered with standard microscopy, bi-dimensional Raman spectral mapping and fluorescence imaging. A human breast skin sample, embedded in paraffin, was imaged with a swept-source OCT system at 1310 nm. Individual OCT volumes were acquired in fully automated fashion in order to obtain a large field-of-view at high resolution (~10 ...

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    5. Observation and analysis on skin cancer induced by UVB irradiation using optical coherence tomography

      Observation and analysis on skin cancer induced by UVB irradiation using optical coherence tomography

      Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the prevalent skin cancers, which have a quite high incidence in the white race. In recent years, however, their incidences have been increasing in the yellow race, resulting in a great threat to the public health. According to researches, chronics UVB irradiation (280nm~320nm) is the major culprit of skin cancer in humans. In our study, the model of UVB induced skin cancer was established firstly. Optical coherence tomography (OCT) combined with the histopathology was exploited to monitor the morphologic and histological changes of the process of UVB induced skin ...

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    6. Automated identification of basal cell carcinoma by polarization-sensitive optical coherence tomography

      Automated identification of basal cell carcinoma by polarization-sensitive optical coherence tomography

      We report an automated classifier to detect the presence of basal cell carcinoma in images of mouse skin tissue samples acquired by polarization-sensitive optical coherence tomography (PS-OCT). The sensitivity and specificity of the classifier based on combined information of the scattering intensity and birefringence properties of the samples are significantly higher than when intensity or birefringence information are used alone. The combined information offers a sensitivity of 94.4% and specificity of 92.5%, compared to 78.2% and 82.2% for intensity-only information and 85.5% and 87.9% for birefringence-only information. These results demonstrate that analysis of the ...

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    7. In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography

      In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography

      Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology.

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    8. High-definition optical coherence tomography of melanocytic skin lesions

      High-definition optical coherence tomography of melanocytic skin lesions

      High-definition optical coherence tomography and the corresponding vertically sectioned histology of a compound naevus. High-definition optical coherence tomography (HD-OCT) scanners have recently been developed. We assessed micromorphological HD-OCT correlates of benign naevi (BN) and malignant melanoma (MM). 28 BN and 20 MM were studied using HD-OCT and histology. Epidermal honeycomb/cobblestone pattern, regular junctional cell nests, and edged papillae are more often observed in BN, whereas fusion of rete ridges, pagetoid cells and junctional and/or dermal nests with atypical cells are more frequently seen in MM. A high overlap of HD-OCT features in BN and MM was observed and ...

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    9. Optical coherence tomography in the diagnosis of basal cell carcinoma

      Optical coherence tomography in the diagnosis of basal cell carcinoma

      Since its introduction in dermatology in the late 1990s optical coherence tomography (OCT) has been used to study many skin diseases, in particular non-melanoma skin cancer and it s precursors. Special attention has been paid to superficial basal cell carcinoma (BCC), and a number of smaller observational studies have been published. The diagnostic criteria for BCC of these studies are systematically reviewed. A systemic review of English language studies was performed using PubMed, Google Scholar and Royal Danish Library, to search for primary papers on OCT and BCC. The references of retrieved papers were searched by hand for further relevant ...

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    10. MULTIMODAL OPTOSPECTRAL INVESTIGATION OF MELANOCYTIC SKIN LESIONS: A CORRELATION STUDY USING OPTICAL COHERENCE TOMOGRAPHY AND DERMOSCOPY

      MULTIMODAL OPTOSPECTRAL INVESTIGATION  OF MELANOCYTIC SKIN LESIONS: A CORRELATION  STUDY USING OPTICAL COHERENCE TOMOGRAPHY  AND DERMOSCOPY

      Optical coherence tomography (OCT) is one of the best options, in terms of skin penetration depth and resolution, for skin lesion diagnosis. This study reports on the use of OCT for the in vivo imaging analysis of 67 melanocytic skin lesions in 34 patients. The OCT results have been compared with the dermoscopy – the standard non-invasive, visible-light-based skin imaging technique. The variations of the OCT imaging correlate with the dermoscopic pattern and presence of dermoscopic structures, like globules, blotches and regression areas. Our study shows that OCT is a promising non-invasive imaging technique for the diagnosis of skin lesions and ...

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    11. Future Prospects in Dermatologic Applications of Lasers, Nanotechnology, and Other New Technologies

      Future Prospects in Dermatologic Applications of Lasers, Nanotechnology, and Other New Technologies

      We review novel technologies with diagnostic and therapeutic applications in dermatology. Among the diagnostic techniques that promise to become part of dermatologic practice in the future are optical coherence tomography, multiphoton laser scanning microscopy, Raman spectroscopy, thermography, and 7-T magnetic resonance imaging. Advances in therapy include novel light-based treatments, such as those applying lasers to new targets and in new wavelengths. Devices for home therapy are also appearing. We comment on the therapeutic uses of plasma, ultrasound, radiofrequency energy, total reflection amplification of spontaneous emission of radiation, light stimulation, and transepidermal drug delivery. Finally, we mention some basic developments in ...

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    12. Differentiating allergic and irritant contact dermatitis by high-definition optical coherence tomography: a pilot study

      Differentiating allergic and irritant contact dermatitis by high-definition optical coherence tomography: a pilot study

      Differentiation of allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD) is important because of different management requirements. Various non-invasive tests have been used in an attempt to improve diagnosis. In irritant dermatitis, thickening of the epidermis has been a constant finding. High-Definition Optical Coherence Tomography (HD-OCT) is a non-invasive real-time three-dimensional imaging technique with cellular resolution for which an adapted algorithmic method for pattern analysis discriminating inflammatory skin diseases has been proposed. The aim of this study was threefold. (1) To evaluate the correlation between HD-OCT features and clinical scores of allergic and irritant patch test reactions. (2) To ...

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    13. Imaging of collagen deposition disorders using optical coherence tomography

      Imaging of collagen deposition disorders using optical coherence tomography

      Background Collagen deposition disorders such as hypertrophic scars, keloids and scleroderma can be associated with significant stigma and embarrassment. These disorders often constitute considerable impairment to quality of life, with treatment posing to be a substantial challenge. Optical coherence tomography (OCT) provides a non-invasive, easily applicable bedside optical imaging method for assessment of the skin. It is hypothesized that OCT imaging may be useful in assessing fibrosis to avoid additional biopsies that could potentially worsen the scarring. Method Thirty-three patients with ordinary scars, hypertrophic scars, keloid scarring, lichen sclerosus et atrophicus and localized or systemic scleroderma were recruited for this ...

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    14. Functional optical coherence tomography of pigmented lesions

      Functional optical coherence tomography of pigmented lesions

      Background Cutaneous melanomas are diagnosed worldwide in 231 130 patients per year. The sensitivity and specificity of melanoma diagnosis expresses the need for an additional diagnostic method. Optical coherence tomography (OCT) has shown that it allows morphological (qualitative) description of image features and quantitative analysis of pathology related light scattering by means of the attenuation coefficient (μ oct ). Objective We hypothesize that OCT images of nevi will differ qualitatively and quantitatively from melanomas. Methods Forty lesions from 33 consecutive patients were imaged with OCT. After data acquisition, excision was performed. Epidermal layer thickness was measured and values of μ oct were extracted ...

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    15. Volumetric cutaneous microangiography of human skin in vivo by VCSEL swept-source optical coherence tomography

      Volumetric cutaneous microangiography of human skin in vivo by VCSEL swept-source optical coherence tomography

      We demonstrate volumetric cutaneous microangiography of the human skin in vivo that utilises 1.3-μm high-speed sweptsource optical coherence tomography (SS-OCT). The swept source is based on a micro-electro-mechanical (MEMS)-tunable vertical cavity surface emission laser (VCSEL) that is advantageous in terms of long coherence length over 50 mm and 100 nm spectral bandwidth, which enables the visualisation of microstructures within a few mm from the skin surface. We show that the skin microvasculature can be delineated in 3D SS-OCT images using ultrahigh-sensitive optical microangiography (UHS-OMAG) with a correlation mapping mask, providing a contrast enhanced blood perfusion map with ...

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    16. High-Definition Optical Coherence Tomography in the Diagnosis of Basal Cell Carcinoma Evaluated by an Experienced Versus Inexperienced Investigator

      High-Definition Optical Coherence Tomography in the Diagnosis of  Basal Cell Carcinoma Evaluated by an Experienced Versus Inexperienced  Investigator

      Background: Histopathology is the gold standard in the diagnosis of basal cell carcinoma (BCC) but biopsies are invasive and often not the preferred diagnostic method for patients. In this context, non-invasive diagnostic imaging tools such as high definition optical coherence tomography (HD-OCT) have shown promising results in diagnosing BCC in real time, atraumatically and repeatedly. Objective: To evaluate the sensitivity and specificity of HD-OCT in the diagnosis of BCC by an experienced versus an inexperienced investigator and describe typical features in common differential diagnosis of BCC. Patients and methods: Forty three patients with clinical suspicion for BCC were included. The ...

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    17. Histogram flow mapping with optical coherence tomography for in vivo skin angiography of hereditary hemorrhagic telangiectasia

      Histogram flow mapping with optical coherence tomography for in vivo skin angiography of hereditary hemorrhagic telangiectasia

      Speckle statistics of flowing scatterers have been well documented in the literature. Speckle variance optical coherence tomography exploits the large variance values of intensity changes in time caused mainly by the random backscattering of light resulting from translational activity of red blood cells to map out the microvascular networks. A method to map out the microvasculature malformation of skin based on the time-domain histograms of individual pixels is presented with results obtained from both normal skin and skin containing vascular malformation. Results demonstrated that this method can potentially map out deeper blood vessels and enhance the visualization of microvasculature in ...

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    18. Optical characterization of facial foundation applied to skin replicas by using visible FF-OCT

      Optical characterization of facial foundation applied to skin replicas by using visible FF-OCT

      We have developed a new type of optical coherence tomography using visible-LED sources to investigate light propagation in a make-up skin and measure the thickness of facial foundation. The thickness is estimated by the difference between the three-dimensional tomographic images of a skin replica before and after applying facial foundation. Finally, we demonstrate experimentally that this work is the first step to investigate the relation between the appearance and the light propagation in the make-up

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    19. Full-depth epidermis tomography using a Mirau-based full-field optical coherence tomography

      Full-depth epidermis tomography using a Mirau-based full-field optical coherence tomography

      With a Gaussian-like broadband light source from high brightness Ce 3+ :YAG single-clad crystal fiber, a full-field optical coherence tomography using a home-designed Mirau objective realized high quality images of in vivo and excised skin tissues. With a 40 × silicone-oil-immersion Mirau objective, the achieved spatial resolutions in axial and lateral directions were 0.9 and 0.51 μm, respectively. Such a high spatial resolution enables the separation of lamellar structure of the full epidermis in both the cross-sectional and en face planes. The number of layers of stratum corneum and its thickness were quantitatively measured. This label free and non-invasive ...

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    20. Dermascope guided multiple reference optical coherence tomography

      Dermascope guided multiple reference optical coherence tomography

      In this paper, we report the feasibility of integrating a novel low cost optical coherence tomography (OCT) system with a dermascope for point-of-care applications. The proposed OCT system is based on an enhanced time-domain optical coherence tomographic system, called multiple reference OCT (MR-OCT), which uses a single miniature voice coil actuator and a partial mirror for extending the axial scan range. The system can simultaneously register both the superficial dermascope image and the depth-resolved OCT sub-surface information by an interactive beam steering method. A practitioner is able to obtain the depth resolved information of the point of interest by simply ...

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    21. Treatment monitoring of topical ingenol mebutate in actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy: a case series

      Treatment monitoring of topical ingenol mebutate in actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy: a case series

      ingenol mebutate gel has been approved lately for the topical treatment of actinic keratoses (AK). Modern imaging techniques such as optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) have been shown useful for the non-invasive diagnostics of non-melanoma skin cancer 1-6 . Both techniques differ in optical resolution and penetration depth.

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      Mentions: Tanja Maier
    22. A multicentre pilot study investigating high-definition optical coherence tomography in the differentiation of cutaneous melanoma and melanocytic naevi

      A multicentre pilot study investigating high-definition optical coherence tomography in the differentiation of cutaneous melanoma and melanocytic naevi

      Background High-definition optical coherence tomography scanners have recently been developed. Objectives To assess the diagnostic performance of HD-OCT in the differentiation of benign melanocytic skin lesions (MSL) and cutaneous melanoma (CM). Methods Patients with MSL were assessed by HD-OCT. All diagnoses were histopathologically confirmed. One blinded observer evaluated both slice and en-face HD-OCT images and diagnosed MLS on the basis of an algorithm adopted from reflectance confocal microscopy, recent HD-OCT reports, and conventional OCT. Results A total of 93 MSL were studied comprising 66 benign MSL and 27 CM. The sensitivity of HD-OCT was 74.1% [95% confidence interval (CI ...

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    23. Optical coherence tomography applied to tests of skin care products in humans – a case study

      Optical coherence tomography applied to tests of skin care products in humans – a case study

      Background/purpose When evaluating skin care products for human skin, quantitative test methods need to be simple, precise and reliable. Optical coherence tomography (OCT), provides high-resolution sectional images of translucent materials to a depth of a few millimeters, a technique usually applied to medical measurements in ophthalmology and dermatology. This study aimed to demonstrate the application of OCT as the main technique for monitoring changes in skin topography during tests of a wrinkle-reduction product in humans. Methods We used a commercial OCT apparatus to perform clinical examinations of skin roughness in treated and non-treated sites in the periorbital region of ...

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      Mentions: Marcus P. Raele
    1-24 of 472 1 2 3 4 ... 18 19 20 »
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