1. Articles in category: Dermatology

    1-24 of 851 1 2 3 4 ... 34 35 36 »
    1. Comparative “virtual biopsies” of normal skin and skin lesions using vibrational optical coherence tomography

      Comparative “virtual biopsies” of normal skin and skin lesions using vibrational optical coherence tomography

      Background Increased tissue stiffness (also termed modulus) has been shown to be a characteristic of potential tumor metastasis. Measured values of the stiffness of tumors and cancer cells are reported in the literature to increase compared to neighboring normal tissues. Yet the relationship between the mechanical properties of cells and the extracellular matrix has yet to be correlated with the histopathology of cancerous lesions. Materials and Methods We have developed a technique to do virtual biopsies of skin lesions by combining images made using optical coherence tomography with stiffness measurements made simultaneously using vibrational analysis. The technique is termed vibrational ...

      Read Full Article
      Mentions: OptoVibronex
    2. Optical coherence tomography correlates multiple measures of tissue damage following acute burn injury

      Optical coherence tomography correlates multiple measures of tissue damage following acute burn injury

      Background: The visual assessment of burned skin is inherently subjective, and whilst a number of imaging modalities have identified quantifiable parameters to characterize vascular and structural changes following burn damage, none have become common place in the assessment protocol. Here, we use optical coherence tomography (OCT)-based angiography (OCTA) to introduce novel correlations between vessel depth, i.e., the depth of functional blood vessels beneath the tissue surface, edema depth, i.e., the depth of interstitial fluid buildup beneath the tissue surface, and tissue injury depth, i.e., the depth of collagen denaturation beneath the tissue surface, following burn injury ...

      Read Full Article
    3. Quantitative assessment of skin swelling using optical coherence tomography

      Quantitative assessment of skin swelling using optical coherence tomography

      Background Preclinical and clinical studies suggest that optical coherence tomography (OCT) is a useful tool to visualize inflammatory conditions. Objective The objective of this study was to evaluate the usefulness of combining OCT and various image processing techniques for quantitative assessment of histamine-induced tissue swelling. Methods Both time-domain and frequency-domain OCT were used on a mouse ear model. The ear thickness and volume before and after histamine challenge were determined from pixel locations in 2D scans and voxel number counting in 3D scans. Swelling kinetics was analyzed on 3D contour mapping. Microvessel network was visualized using speckle decorrelation analysis. Results ...

      Read Full Article
    4. Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography

      Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography

      Optical coherence tomography angiography (OCTA) provides in-vivo images of microvascular perfusion in high resolution. For its application to basic and clinical research, an automatic and robust quantification of the capillary architecture is mandatory. Only this makes it possible to reliably analyze large amounts of image data, to establish biomarkers, and to monitor disease developments. However, due to its optical properties, OCTA images of skin often suffer from a poor signal-to-noise ratio and contain imaging artifacts. Previous work on automatic vessel segmentation in OCTA mostly focuses on retinal and cerebral vasculature. Its applicability to skin and, furthermore, its robustness against imaging ...

      Read Full Article
    5. The evolution of healthy skin to acne lesions: a longitudinal, in vivo evaluation with reflectance confocal microscopy and optical coherence tomography

      The evolution of healthy skin to acne lesions: a longitudinal, in vivo evaluation with reflectance confocal microscopy and optical coherence tomography

      Background Comedogenesis is defined as the process of the development of a new comedo, which is of great importance for the understanding of acne. Objective To evaluate the formation and evolution of acne lesions from clinically unaffected skin of patients with mild‐moderate acne to characterize the morphological changes and natural resolution by means of in vivo reflectance confocal microscopy (RCM) and dynamic otpical coherence tomography (D‐OCT). Methods ten patients with mild‐moderate acne, not assuming any topical or systemic therapy, comprised between 12 and 30 years of age, were recruited. A target area of 4x4mm of the face ...

      Read Full Article
    6. Optical Coherence Tomography in Evaluation of Glomus Tumors: A Report of Three Cases

      Optical Coherence Tomography in Evaluation of Glomus Tumors: A Report of Three Cases

      Glomus tumors are painful, benign perivascular neoplasms of the glomus body affecting the nail apparatus. Although diagnosis can be made clinically using Love's and Hildreth's tests, imaging is required to distinguish glomus tumors from other subungual vascular lesions. Clinical diagnosis is complicated when the nail has no visible abnormalities. 1 Magnetic resonance imaging (MRI) is the modality of choice for imaging but requires a dedicated small part coil, which is unavailable at some facilities and is costly. 2

      Read Full Article
    7. High-accurate and robust fingerprint anti-spoofing system using Optical Coherence Tomography

      High-accurate and robust fingerprint anti-spoofing system using Optical Coherence Tomography

      Traditional commercial automated fingerprint recognition systems (AFRSs) are vulnerable to fake attacks by the use of artificial fingerprints, due to its limitation on resolution and the difficulty of obtaining depth information. Developing new systems with strong anti-spoofing ability are of increasing concern in the current digital age. Inspired by the observation and comparison of fingertip skin structure and the one dimensional (1D) depth signals derived from OCT acquisition images between real finger and artificial fingerprints, two novel anti-spoofing features, namely depth-double-peak feature and sub-single-peak feature, were specifically defined. Depth-double-peak feature refers that there must be two and only two peaks ...

      Read Full Article
    8. Researchers invent method to advance non-invasive melanoma identification using radiomic signatures

      Researchers invent method to advance non-invasive melanoma identification using radiomic signatures

      Biopsies have long been considered the diagnostic standard for melanoma, a globally worsening public health problem that has emerged as the deadliest form of skin cancer. Researchers have explored alternative ways to diagnose melanoma, using different imaging techniques to try and reduce the reliance on biopsies. “Performing biopsies can result in pain, anxiety, scarring and disfigurement for patients, as well as a considerable cost to the health care system,” said Mohammad Avanaki, assistant professor of biomedical engineering and director of the OPIRA Laboratory at Wayne State University. “However, imaging devices suffer from various drawbacks that result in limited specificity or ...

      Read Full Article
    9. Noninvasive Determination of Epidermal and Stratum Corneum Thickness in vivo Using Two-Photon Microscopy and Optical Coherence Tomography: Impact of Body Area, Age, and Gender

      Noninvasive Determination of Epidermal and Stratum Corneum Thickness in vivo Using Two-Photon Microscopy and Optical Coherence Tomography: Impact of Body Area, Age, and Gender

      Background: High-resolution images of the epidermis are important to understand the transdermal penetration and changes in epidermal components. Both ex vivo and in vivo technologies are available to picture the epidermal thickness (ET). So far, the illustration of the stratum corneum (SC) has not been possible without artifacts. Objective: Precision in vivo measurement of the ET and SC, duly considering the impact of location on the body, age, and gender. Methods: In this pilot study on 20 skin-healthy subjects aged 18–66 years, the ET was imaged by two-photon microscopy (2PM) and optical coherence tomography (OCT), and the SC by ...

      Read Full Article
    10. The effect of melanin on in vivo optical coherence tomography of the skin in a multiethnic cohort

      The effect of melanin on in vivo optical coherence tomography of the skin in a multiethnic cohort

      Background Noninvasive real‐time assessment of living tissue is quickly becoming invaluable for bolstering histologic and dermatoscopic measures of cutaneous conditions. While many skin researchers have explored the utility of noninvasive imaging in inflammatory and malignant skin conditions, there is yet to be a definitive and direct assessment of the effects of melanin on the quality of optical coherence tomography (OCT) imaging and its accuracy in multiethnic patient populations. We conducted a study to evaluate the effects of melanin on the quality of in vivo OCT imaging. Methods Volunteers of all Fitzpatrick skin types were imaged once in five skin ...

      Read Full Article
    11. Evaluation of positive patch test reactions using optical coherence tomography: A pilot study

      Evaluation of positive patch test reactions using optical coherence tomography: A pilot study

      Introduction Patch testing is the gold standard for evaluating allergic contact dermatitis (ACD), yet current interpretation methods are limited by their subjectivity and possible variability between observers. Optical coherence tomography (OCT) imaging enables noninvasive in vivo skin visualization and holds promise as an objective method of patch test interpretation. Objective To evaluate the micromorphological changes of patch test reactions and identify objective, quantitative OCT markers that correlate with clinically graded patch test reactions. Results A total of 25 patch test reactions (7 grade‐0, 4 grade‐1+, 14 grade‐2+) from 7 patients underwent OCT evaluation. Increased epidermal thickness and ...

      Read Full Article
    12. The Use of Fractional Ablative CO2 Laser vs Control on Acute Traumatic Injuries to Prevent Scar Formation

      The Use of Fractional Ablative CO2 Laser vs Control on Acute Traumatic Injuries to Prevent Scar Formation

      Surgical standard for treating traumatic burn injury scarring is to wait one year following the initial assault prior to beginning treatment. This study investigates the use of fractional ablative CO2 laser when begun within 3 months of a traumatic burn injury and it's impact on scar formation compared to the control. We hypothesized that early intervention would substantially mitigate the formation of scar tissue and help restore more normal appearing skin.

      Read Full Article
    13. Melanoma Blood Vessel Changes Detected with OCT Imaging

      Melanoma Blood Vessel Changes Detected with OCT Imaging

      An international team of researchers has proven that dynamic optical coherence tomography (D-OCT) imaging of melanoma reveals changes to the blood vessels that correlate with the depth of its invasion, which could lead to a faster method of rapidly assessing the severity of a melanoma. Nathalie de Carvalho, of the University of Modena and Reggio Emilia, explained that cancers grow their own blood vessel network to supply oxygen and nutrients. “We analyzed the shapes of the vessels in the OCT images of melanomas and correlated the frequency of different shapes with the Breslow depths [the thickness of the tumors, measured ...

      Read Full Article
    14. Optical coherence tomography for diagnosis of BCC

      Optical coherence tomography for diagnosis of BCC

      Basal cell carcinoma (BCC) is the most common form of skin cancer in the world. Its incidence in Europe has increased at an alarming rate of 5.5% per year over the past four decades. In the U.K., the incidence of BCC has risen at a rate six times higher than in the rest of Europe. The diagnosis of BCC typically requires a biopsy of the skin and careful analysis under a microscope. Optical coherence tomography (OCT) is an imaging tool that uses light to visualize the layers underneath the skin surface in real‐time without the need to ...

      Read Full Article
    15. Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care Cream

      Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care Cream

      In the realm of cosmetics, skin care accounts for a significant share accounting for 35.3% of the global market, creating a $121 billion industry. While many of the products claim to have unique, natural formulations that boost skin care, many products contain chemicals that are potentially damaging to skin. Such ingredients include preservatives, parabens, fragrances, and formaldehyde, which can cause skin irritation and inflammation. Although these ingredients help to preserve the stability and longevity of products, it is plausible to achieve efficacy and improve skin structure without risking unnecessary damage. The condition and health of the dermis rely largely ...

      Read Full Article
    16. Potential of contrast agents to enhance in vivo confocal microscopy and optical coherence tomography in dermatology: A review

      Potential of contrast agents to enhance in vivo confocal microscopy and optical coherence tomography in dermatology: A review

      Distinction between normal skin and pathology can be a diagnostic challenge. This systematic review summarizes how various contrast agents, either topically delivered, or injected into the skin affect distinction between skin disease and normal skin when imaged by optical coherence tomography (OCT) and confocal microscopy (CM). A systematic review of in vivo OCT and CM studies using exogenous contrast agents on healthy human skin or skin disease was performed. In total, 9 CM studies and 1 OCT study were eligible. Four contrast agents aluminum chloride (AlCl) n=2, indocyanin green (ICG) n=3, sodium fluorescein n=3 and acetic acid ...

      Read Full Article
    17. Diagnostic Accuracy of Reflectance Confocal Microscopy for Diagnosis of Skin Lesions: An Update

      Diagnostic Accuracy of Reflectance Confocal Microscopy for Diagnosis of Skin Lesions: An Update

      Context.— Histopathology is the current standard to diagnose skin disease. However, biopsy may not always be feasible, such as in patients with multiple nevi, a patient with a lesion on an aesthetically significant site, or in children. Recently, noninvasive techniques, including reflectance confocal microscopy (RCM), optical coherence tomography, and Raman spectroscopy, have enabled dermatologists to manage skin lesions in real time without the need for biopsy. Objective.— To report the updated diagnostic accuracy of RCM for equivocal skin lesions. Design.— In this study, we retrospectively reviewed our data of clinically suspicious lesions from 2010 to 2017 that were evaluated by ...

      Read Full Article
    18. Transfollicular delivery of gold microparticles in healthy skin and acne vulgaris, assessed by in vivo reflectance confocal microscopy and optical coherence tomography

      Transfollicular delivery of gold microparticles in healthy skin and acne vulgaris, assessed by in vivo reflectance confocal microscopy and optical coherence tomography

      Introduction Topical application of gold microparticles (GMPs) for selective photothermolysis is a recently FDA‐cleared therapy for acne vulgaris. Current evidence indicates the potential of optical imaging to non‐invasively visualize GMPs and describe photothermal tissue effects. Objectives To qualitatively and quantitatively describe GMP delivery in vivo and visualize laser‐mediated thermal effects of GMPs in facial skin of acne patients and healthy participants, using reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). Methods Patients with facial acne ( n  = 14), and healthy participants ( n  = 7) were included. RCM and OCT images were acquired at baseline, after GMP application, and ...

      Read Full Article
    19. Nickel contact dermatitis evaluated by means of optical coherence tomography: first impressions

      Nickel contact dermatitis evaluated by means of optical coherence tomography: first impressions

      Nickel contact allergy, a major health problem in the general population, is usually diagnosed through appropriate clinical history and patch testing.(1, 2) Patch‐test results are not fully objectivable and are influenced by the observer's experience.(3) Moreover, not every individual with nickel‐sensitization develops a clinically visible contact allergy. We hypothesized that non‐invasive diagnostic techniques such as optical coherence tomography (OCT) could provide further details in interpreting patch‐tests and eventually detect subclinical changes in subjective reactions to known contact allergens.

      Read Full Article
    20. Real-time quantification of skin burns in external beam radiation therapy

      Real-time quantification of skin burns in external beam radiation therapy

      A system for radiation therapy include an imaging device (108) configured to scan an area of interest for tissue undergoing radiation therapy to collect one or more images of the tissue. An interpretation module (110) is configured to receive the one or more images of the tissue to determine a burn status of the tissue and provide adjustments for a radiation treatment plan in accordance with the burn status.

      Read Full Article
    21. (Cost)-Effectiveness of OCT in BCC (ROCTI)

      (Cost)-Effectiveness of OCT in BCC (ROCTI)

      Skin cancer incidence rises worldwide due to high sun exposure and ageing. Basal cell carcinoma (BCC) is the most prevalent form, with a lifetime risk of 16-20% in the Netherlands. Currently, the gold standard for diagnosing and subtyping basal cell carcinoma (BCC) is a punch biopsy. Since this technique is invasive, new non-invasive diagnostic methods have been developed, including optical coherence tomography (OCT). In patients with clinical and dermoscopic suspicion of BCC, OCT makes it possible to confirm and subtype BCC with high confidence, thereby obviating the need for a punch biopsy in a substantial part of patients. Hence, BCC ...

      Read Full Article
    1-24 of 851 1 2 3 4 ... 34 35 36 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (1 articles) University of Washington
  4. People in the News

    1. (1 articles) Ruikang K. Wang
  5. OCT Companies in the News

    1. (1 articles) OptoVibronex