1. Articles in category: Dermatology

    1-24 of 491 1 2 3 4 ... 19 20 21 »
    1. Identification of layers in optical coherence tomography of skin: comparative analysis of experimental and Monte Carlo simulated images

      Identification of layers in optical coherence tomography of skin: comparative analysis of experimental and Monte Carlo simulated images

      Background/purpose The goal of the study is comparative analysis of the layers in OCT images and the morphological structure of skin with thick and thin epidermis. Methods We analyzed the difference between skin with thin and thick epidermis in two ways. The first approach consisted in determination of the thicknesses of layers of skin with thin and thick epidermis of different localizations from experimental OCT images. The second approach was to develop numerical models fitting experimental OCT images based on Monte Carlo simulations revealing structure and optical parameters of layers of skin with thick and thin epidermis. Results The ...

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    2. A case report of differentiating staphylococcal scalded skin syndrome and toxic epidermal necrolysis by optical coherence tomography

      A case report of differentiating staphylococcal scalded skin syndrome and toxic epidermal necrolysis by optical coherence tomography

      Background Staphylococcal scalded skin syndrome (SSSS) and toxic epidermal necrolysis (TEN) both present with acute onset, high morbidity and significant mortality. Rapid diagnosis is therefore of importance. The aim of this study was to investigate and compare the presentation of these diseases using optical coherence tomography (OCT). Methods Two male patients with bullous diseases, SSSS and TEN, respectively, were photographed digitally, examined using dermoscopy, OCT scanned and subsequently biopsied in the said order. Results The bullous skin was visualized by OCT showing two distinct images: the SSSS-patient displayed superficial hyporefletive flaccid structures with a split high in the thickened (0 ...

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    3. Measurements of the thermal coefficient of optical attenuation at different depth regions of in vivo human skins using optical coherence tomography: a pilot study

      Measurements of the thermal coefficient of optical attenuation at different depth regions of in vivo human skins using optical coherence tomography: a pilot study

      We present detailed measurement results of optical attenuation’s thermal coefficients (referenced to the temperature of the skin surface) in different depth regions of in vivo human forearm skins using optical coherence tomography (OCT). We first design a temperature control module with an integrated optical probe to precisely control the surface temperature of a section of human skin. We propose a method of using the correlation map to identify regions in the skin having strong correlations with the surface temperature of the skin and find that the attenuation coefficient in these regions closely follows the variation of the surface temperature ...

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    4. Processing Optical Coherence Tomography Scans Of A Subject'S Skin

      Processing Optical Coherence Tomography Scans Of A Subject'S Skin

      A method of processing optical coherence tomography (OCT) scans of a subject's skin (7), the skin (7) having a surface(8), the method comprising capturing a plurality of scans through the subject's skin(7), the scans representing an OCT signal in slices through the user's skin (7) in parallel planes, the scans being offset from one another along a direction perpendicular to the parallel planes, the method comprising determining the position of the surface (8) of the skin (7) in each scan and displaying the scans to a user with an indication (9) indicative of a predetermined ...

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    5. Optical Coherence Tomography and Its Role for Delineating the Thickness of Keratinocyte Dysplasia and Neoplasia

      Optical Coherence Tomography and Its Role for Delineating the Thickness of Keratinocyte Dysplasia and Neoplasia

      Optical coherence tomography (OCT) can produce cross-sectional and en face, non-invasive, real-time images of skin. OCT produces high-resolution images at a micrometre resolution and has a maximum 2-mm penetration depth, which places OCT in the imaging gap between ultrasound and confocal microscopy. Much OCT research has been performed on keratinocyte dysplasia and neoplasia, primarily including basal cell carcinoma (BCC) and actinic keratosis. In regards to BCC and actinic keratosis, architectural disarray of the epidermis is an overall characteristic finding in OCT images. OCT can reliably differentiate between normal and lesional skin, which is of great importance when identifying tumour borders ...

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    6. Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking

      Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking

      We demonstrate the in vivo assessment of human scars by parametric imaging of birefringence using polarization-sensitive optical coherence tomography (PS-OCT). Such in vivo assessment is subject to artifacts in the detected birefringence caused by scattering from blood vessels. To reduce these artifacts, we preprocessed the PS-OCT data using a vascular masking technique. The birefringence of the remaining tissue regions was then automatically quantified. Results from the scars and contralateral or adjacent normal skin of 13 patients show a correspondence of birefringence with scar type: the ratio of birefringence of hypertrophic scars to corresponding normal skin is 2.2 ± 0.2 ...

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    7. Assessment of laser-induced acceleration effects in optical clearing of in vivo human skin by optical coherence tomography

      Assessment of laser-induced acceleration effects in optical clearing of in vivo human skin by optical coherence tomography

      Laser irradiation is considered to be a promising innovative technology which has been developed in an attempt to increase transdermal drug delivery. In this study, a near-infrared CW diode laser (785 nm) was applied to increase permeability of glycerol solutions in human skin in vivo and improve the optical clearing efficacy. Results show that for both 15%v/v and 30%v/v glycerol, the permeability coefficient increased significantly if the detected area of the skin tissue was treated with laser irradiation before optical clearing agents (OCAs) were applied. This study based on optical coherence tomography imaging technique and optical ...

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    8. Cross-evaluation of optimal glycerol concentration to enhance optical tissue clearing efficacy

      Cross-evaluation of optimal glycerol concentration to enhance optical tissue clearing efficacy

      Background/aims The efficacy of light therapeutic and diagnostic applications can be enhanced by employing optical tissue clearing (OTC) agents to minimize light scattering in tissue. This study aimed to investigate the optimal concentration of glycerol, so that it can be efficiently used as an OTC agent in dermatology. Methods Glycerol was topically applied to avoid the possibility of edema that could be caused by dermal injection. The efficacy of glycerol was quantitatively evaluated for various concentrations using optical coherence tomography (OCT) to evaluate light scattering and ultrasound imaging modality to evaluate collagen dissociation. Results The intensity in the OCT ...

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    9. Optical coherence tomography: a potential tool for prediction of treatment response for port wine stain after photodynamic therapy

      Optical coherence tomography: a potential tool for prediction of treatment response for port wine stain after photodynamic therapy

      Response of port wine stain (PWS) to photodynamic therapy treatment (PDT) is variable and depends on treatment setting used and anatomic sites as well as on size and depth of ectatic vessels. Optical coherence tomography (OCT) is a non-destructive imaging modality which can reveal the layered structure of the upper part of the skin. The structural features of the PWS skin such as the diameter and depth of the blood vessels in different anatomic sites can be showed in the OCT images. In this study, the possible role of PWS skin structure in the response to PDT is assessed. 82 ...

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    10. Noninvasive monitoring of photodynamic therapy on skin neoplastic lesions using the optical attenuation coefficient measured by optical coherence tomograph

      Noninvasive monitoring of photodynamic therapy on skin neoplastic lesions using the optical attenuation coefficient measured by optical coherence tomograph

      Photodynamic therapy (PDT) has become a promising alternative for treatment of skin lesions such as squamous cell carcinoma. We propose a method to monitor the effects of PDT in a noninvasive way by using the optical attenuation coefficient (OAC) calculated from optical coherence tomography (OCT) images. We conducted a study on mice with chemically induced neoplastic lesions and performed PDT on these lesions using homemade photosensitizers. The response of neoplastic lesions to therapy was monitored using, at the same time, macroscopic clinical visualization, histopathological analysis, OCT imaging, and OCT-based attenuation coefficient measurement. Results with all four modalities demonstrated a positive ...

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    11. In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography: Diagnosis, Pathogenesis, and Treatment

      In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography: Diagnosis, Pathogenesis, and Treatment

      Miliaria profunda (MP) is a condition of sweat duct obstruction manifesting with generalized papular eruption and anhidrosis. 1 , 2 Using imaging with high-definition optical coherence tomography (HD-OCT), we identified, in vivo, the depth of lesions in MP and the likely location of sweat duct obstruction. To our knowledge, this is the first time such an evaluation has been performed.

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    12. Feature Of The Week 11/16/14: In Vivo Analysis of Burns in a Mouse Model using Spectroscopic OCT

      Feature Of The Week 11/16/14: In Vivo Analysis of Burns in a Mouse Model using Spectroscopic OCT

      Evaluation of burn severity is a significant clinical problem with over 2 million burns reported each year in the United States [1]. The magnitude of this clinical need has inspired the development of many technologies to assess burn depth, but none of these have been widely adopted as clinical judgment still relies primarily on visual inspection, with an accuracy of about 70% [2]. A recent study by researchers at Duke University used spectroscopic optical coherence tomography (OCT) to evaluate burned animal tissues in vivo. Spectroscopic OCT is an extension of conventional OCT that can measure depth-resolved scattering and absorption spectra ...

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    13. In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography: Diagnosis, Pathogenesis, and Treatment

      In Vivo Imaging of Miliaria Profunda Using High-Definition Optical Coherence Tomography: Diagnosis, Pathogenesis, and Treatment

      Miliaria profunda (MP) is a condition of sweat duct obstruction manifesting with generalized papular eruption and anhidrosis. 1 , 2 Using imaging with high-definition optical coherence tomography (HD-OCT), we identified, in vivo, the depth of lesions in MP and the likely location of sweat duct obstruction. To our knowledge, this is the first time such an evaluation has been performed.

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    14. Fabrication of a novel dissolving polymer microneedle patch for transdermal drug delivery

      Fabrication of a novel dissolving polymer microneedle patch for transdermal drug delivery

      Polymer microneedles (MNs) have gained increasing attention as a minimally invasive method for efficiently delivering drugs and vaccines in a patient-friendly manner. Herein, an easy and mild process with O2 plasma treatment was used to fabricate polyvinylpyrrolidone (PVP)/polyvinyl alcohol (PVA) MN patches, and efficient, sustained transdermal delivery was achieved. The diffusion rate of the entrained molecules could be controlled by adjusting the ratio of PVP/PVA. Optical coherence tomography was used to monitor the in vitro penetration in real time and to measure the penetration depth. Rhodamine 6G and fluorescein isothiocyanate-labeled bovine serum albumin (BSA-FITC) were used to explore ...

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    15. In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea

      In Vivo High-Definition Optical Coherence Tomography: A Bedside Diagnostic Aid for Morphea

      Optical coherence tomography (OCT) is a noninvasive imaging technique that allows real-time high-definition cross-sectional visualization of tissues. Conventional OCT was introduced in dermatology in 1997 and has shown benefit in evaluating malignant neoplasms and inflammatory skin disorders. 1 , 2 High-definition OCT (HD-OCT) scanners have recently been developed; they provide a higher resolution than conventional OCT and horizontal, in additional to vertical, sectional imaging, which conventional OCT does not provide.

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    16. MedLumics Introduces NITID Skin Imaging System at EADV

      MedLumics Introduces NITID Skin Imaging System at EADV

      MedLumics, a medical imaging company specializing in advanced optical coherence tomography (OCT) technology, debuted its NITID TM skin imaging system at the 23 rd Annual European Academy of Dermatology and Venereology Congress in Amsterdam. NITID is a handheld diagnostic device designed to help dermatologists quickly and minimally invasively diagnose skin cancer. Once approved by regulatory bodies, it will be the first point-of-care OCT imaging device that can produce dynamic, real-time, high-resolution diagnostic images with tissue penetration capability of up to two millimeters. “NITID is the result of a decade of research in optical miniaturization technology, and we are thrilled to ...

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    17. Three-Dimensional High Definition-Optical Coherence Tomography Image Acquisition Procedure For Basal Cell Carcinoma

      Three-Dimensional High Definition-Optical Coherence Tomography Image Acquisition Procedure For Basal Cell Carcinoma

      We read with great interest the paper "Histopathological correlates of basal cell carcinoma in slice and en-face imaging modes of high-definition optical coherence tomography" by Gambichler et al. Optical Coherence Tomography (OCT) seems an interesting technology to study skin tumours. In particular it has been found helpful for basal cell carcinoma (BCC) diagnosis in several investigations. 

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    18. Great EADV meeting in Amsterdam | Eduardo Margallo

      Great EADV meeting in Amsterdam | Eduardo Margallo

      MedLumics demonstrated NITID™, a new skin imaging solution providing simultaneous Optical Coherence Tomography and video dermoscopy in a hand-held battery-operated system. This revolution in skin care, designed for the daily dermatology practice, will be commercially available soon.

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    19. Michelson Diagnostics launches new improved version of VivoSight OCT scanner with Micro-Camera to aid skin cancer diagnosis

      Michelson Diagnostics launches new improved version of VivoSight OCT scanner with Micro-Camera to aid skin cancer diagnosis

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, announces the launch of a new improved version of its innovative VivoSight OCT scanner at the European Academy of Dermatology and Venereology (EADV) Annual Meeting, 8-12 October, Amsterdam. The VivoSight scanner probe is now equipped with a new Micro Camera that provides the user with a real-time, colour, magnified view of the skin lesion being scanned. The new Micro Camera image is shown simultaneously with the vertical and en face OCT images, making the VivoSight scanner the only dermatological clinical OCT device to provide ...

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    20. Ex-vivo multi-modal microscopy of healthy skin

      Ex-vivo multi-modal microscopy of healthy skin

      The thorough characterization of skin samples is a critical step in investigating dermatological diseases. The combination of depth-sensitive anatomical imaging with molecular imaging has the potential to provide vast information about the skin. In this proof-of-concept work we present high-resolution mosaic images of skin biopsies using Optical Coherence Tomography (OCT) manually co-registered with standard microscopy, bi-dimensional Raman spectral mapping and fluorescence imaging. A human breast skin sample, embedded in paraffin, was imaged with a swept-source OCT system at 1310 nm. Individual OCT volumes were acquired in fully automated fashion in order to obtain a large field-of-view at high resolution (~10 ...

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    1-24 of 491 1 2 3 4 ... 19 20 21 »
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