1. Articles in category: Dermatology

    1-24 of 703 1 2 3 4 ... 28 29 30 »
    1. Classification of Fingerprints Captured Using Optical Coherence Tomography

      Classification of Fingerprints Captured Using Optical Coherence Tomography

      We propose a technique for analysis of fingerprints scanned free-air (not pressed against a glass) with Optical Coherence Tomography (OCT). Fingerprints from the surface and subdermal parts of the finger are extracted from a 2 GB volumetric scan in cca. 2 s using our specialized technique and GPU acceleration on GeForce GTX 980. The technique provides fingerprints that perform with promising error rates that demonstrate the potential of the OCT for improved fingerprint identification, as well as its potential for prevention of biometric spoofing (PAD).

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    2. Iron-oxide nanoparticles powered micro optical coherence tomography for in situ imaging the penetration and swelling of polymeric microneedles in skin

      Iron-oxide nanoparticles powered micro optical coherence tomography for in situ imaging the penetration and swelling of polymeric microneedles in skin

      In recent years, polymeric microneedles (MNs) have attracted keen interests among researchers for their applicability in transdermal drug delivery and interstitial skin fluid (ISF) extraction. When design and characterize such devices, it is critical to monitor their real-time in vitro and in vivo performances to optimize the desired effects, yet most of the existing methods are incapable of such functions. To address this unmet need, we develop a real-time non-invasive imaging methodology by integrating iron oxide (Fe3O4) nanoparticles into polymeric MNs to enhance image contrast for micro-optical coherence tomography (µOCT) imaging. Using the Fe3O4 integrated polystyrene-block-poly (acrylic acid) (PS-b-PAA) MNs ...

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      Mentions: Linbo Liu
    3. Freeze artifact on full-field optical coherence tomography skin imaging

      Freeze artifact on full-field optical coherence tomography skin imaging

      Background/Purpose Full-field optical coherence tomography (FFOCT) is an emerging imaging technique for rapid histological analysis. As FFOCT is introduced into the Mohs workflow, it is important to document the effect of tissue freezing on FFOCT images and any effect FFOCT has on frozen sections. Our study aimed to evaluate the changes on FFOCT images after tissue freezing as well as FFOCT imaging effects on frozen sectioning. Methods Six normal skin specimens were imaged using FFOCT and subsequently frozen using a cryostat. The specimens were then reimaged using FFOCT and compared for any differences. To evaluate the effect of FFOCT ...

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    4. Development and translation of label-free functional microscopy based on optical coherence tomography (Thesis)

      Development and translation of label-free functional microscopy based on optical coherence tomography (Thesis)

      Optical coherence tomography (OCT), an imaging modality based on low coherence interferometry, can be extended to obtain various endogenous functional contrasts. This thesis focuses on the development and translation of angiographic and polarization sensitive (PS) OCT techniques for clinical and preclinical applications. This goal includes four specific aims. The first aim is to develop a clinical imaging system to image the anatomy and microvasculature of human skin. The second aim is to develop a high performance post-processing algorithm for angiographic OCT. Towards this aim, we developed a processing algorithm based on complex differential variance (CDV) and confirmed its performance by ...

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    5. In vivo microvascular imaging of cutaneous actinic keratosis, Bowen's disease and squamous cell carcinoma using Dynamic optical coherence tomography

      In vivo microvascular imaging of cutaneous actinic keratosis, Bowen's disease and squamous cell carcinoma using Dynamic optical coherence tomography

      Background A clear distinction between actinic keratosis (AK), Bowen's disease (BD) and squamous cell carcinoma (SCC) cannot reliably be made by clinical and dermoscopic evaluation alone. Dynamic optical coherence tomography (D-OCT) is a novel angiographic variant of OCT that allows for non-invasive, in vivo evaluation of the cutaneous microvascular morphology. Objective To investigate the microvascular structures of AK, BD and invasive SCC using D-OCT in order to gain insights into the microvascular morphology of lesions in the spectrum of keratinocyte skin cancers. Methods 47 patients with a total of 54 lesions (18 AK, 12 BD and 24 SCC) were ...

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    6. Multimodal texture analysis of OCT images as a diagnostic application for skin tumors

      Multimodal texture analysis of OCT images as a diagnostic application for skin tumors

      Optical coherence tomography (OCT) is an effective tool for determination of pathological topology that reflects structural and textural metamorphoses of tissue. In this paper, we propose a report about our examining of the validity of OCT in identifying changes using a skin cancer texture analysis compiled from Haralick texture features, fractal dimension, complex directional field features and Markov random field method from different tissues. The experimental data set contains 530 OCT images with normal skin and tumors as Basal Cell Carcinoma (BCC), Malignant Melanoma (MM) and Nevus. Speckle reduction is an essential pre-processing part for OCT image analyze. In this ...

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    7. Damae Medical Raises €2M in Funding

      Damae Medical Raises €2M in Funding

      Damae Medical , a Paris, France-based medtech company, closed a €2m funding. Backers included Kurma Partners, Idinvest Partners, News Invest, Paris-Saclay Seed Fund co-managed by Partech Ventures, and private investors. The company intends to use the funds to finance the development and CE marking of OCTAV®, which is scheduled for mid-2018. Founded in September 2014 by Anaïs Barut, CEO, Damae Medical aims to provide dermatologists with a novel, in vivo imaging technology for a deep look into the skin. This technology enables cellular-resolution imaging of the skin similar to histology, without the need for tissue excision and processing. The company ...

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    8. Semi-automated localization of dermal epidermal junction in optical coherence tomography images of skin

      Semi-automated localization of dermal epidermal junction in optical coherence tomography images of skin

      Identifying the location of the dermal epidermal junction (DEJ) in skin images is essential in several clinical applications of dermatology such as epidermal thickness determination in healthy versus unhealthy skins, such as basal cell carcinoma. Optical coherence tomography (OCT) facilitates the visual detection of DEJ in vivo . However, due to the granular texture of speckle and a low contrast between dermis and epidermis, a skin border detection method is required for DEJ localization. Current DEJ algorithms work well for skins with a visible differentiable epidermal layer but not for the skins of different body sites. In this paper, we present ...

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    9. Delineating nonmelanoma skin cancer margins using terahertz and optical imaging

      Delineating nonmelanoma skin cancer margins using terahertz and optical imaging

      We evaluated terahertz reflectance imaging and a combination of terahertz and optical techniques for delineating nonmelanoma skin cancers. After imaging, each terahertz pixel of each specimen was classified as cancerous or normal using a previously determined threshold. Subsequently, cancerous terahertz pixels were re-evaluated with polarization-sensitive optical technique. This additional information enabled us to re-classify each cancerous terahertz pixel using morphological appearance of the structures in the optical images. If the structures in the terahertz pixel appeared normal, the pixel was considered normal. The generalized linear mixture model was implemented to determine the sensitivity and specificity of each method. The model ...

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    10. Monte-Carlo simulation of OCT structural images of human skin using experimental B-scans and voxel based approach to optical properties distribution

      Monte-Carlo simulation of OCT structural images of human skin using experimental B-scans and voxel based approach to optical properties distribution

      A method of optical coherence tomography (OCT) structural images reconstruction using Monte Carlo simulations is described. Biological object is considered as a set of 3D elements that allow simulation of media, structure of which cannot be described analytically. Each voxel is characterized by its refractive index and anisotropy parameter, scattering and absorption coefficients. B-scans of the inner structure are used to reconstruct a simulated image instead of analytical representation of the boundary geometry. Henye-Greenstein scattering function, Beer-Lambert-Bouguer law and Fresnel equations are used for photon transport description. Efficiency of the described technique is checked by the comparison of the simulated ...

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    11. I can’t always play it safe with my patients. That’s why I cautiously innovate

      I can’t always play it safe with my patients. That’s why I cautiously innovate

      A s a profession, doctors are determined and cautious. We are determined to do our best and provide the best care for our patients. But we can be quite cautious about trying out new treatments or technologies to help provide that “best care.” Some hesitation makes sense. Countless treatments that sounded promising at the time fell by the wayside because they didn’t measure up — or caused harm. One example: Fifty years ago, dermatologists often used radiation to treat acne. It seemed to work, but researchers later learned that it increased the risk for thyroid, skin, and other cancers. Yet ...

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      Mentions: Orit Markowitz
    12. An intelligent despeckling method for swept source optical coherence tomography images of skin

      An intelligent despeckling method for swept source optical coherence tomography images of skin

      Optical Coherence Optical coherence tomography is a powerful high-resolution imaging method with a broad biomedical application. Nonetheless, OCT images suffer from a multiplicative artefacts so-called speckle, a result of coherent imaging of system. Digital filters become ubiquitous means for speckle reduction. Addressing the fact that there still a room for despeckling in OCT, we proposed an intelligent speckle reduction framework based on OCT tissue morphological, textural and optical features that through a trained network selects the winner filter in which adaptively suppress the speckle noise while preserve structural information of OCT signal. These parameters are calculated for different steps of ...

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    13. Secure fingerprint identification based on structural and microangiographic optical coherence tomography

      Secure fingerprint identification based on structural and microangiographic optical coherence tomography

      Optical coherence tomography (OCT) allows noncontact acquisition of fingerprints and hence is a highly promising technology in the field of biometrics. OCT can be used to acquire both structural and microangiographic images of fingerprints. Microangiographic OCT derives its contrast from the blood flow in the vasculature of viable skin tissue, and microangiographic fingerprint imaging is inherently immune to fake fingerprint attack. Therefore, dual-modality (structural and microangiographic) OCT imaging of fingerprints will enable more secure acquisition of biometric data, which has not been investigated before. Our study on fingerprint identification based on structural and microangiographic OCT imaging is, we believe, highly ...

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    14. From actinic keratosis to squamous cell carcinoma: pathophysiology revisited

      From actinic keratosis to squamous cell carcinoma: pathophysiology revisited

      The precursor of most cutaneous invasive squamous cell carcinomas (iSCCs) is intraepithelial UV-induced damage, known as field cancerization, which can eventually transform into actinic keratosis (AK). Although AK is the most common precursor of iSCC, many AKs will either persist in the same stage or regress, while only a few will progress into iSCC. Nevertheless, because the progression of individual AKs cannot be predicted, it has been proposed that all AKs, regardless of the grade, should be carefully monitored and appropriately treated in clinical practice. Modern imaging techniques such as dermatoscopy, reflectance confocal microscopy (RCM) and high-definition optical coherence tomography ...

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    15. Quantitative characterization of mechanically indented in vivo human skin in adults and infants using optical coherence tomography

      Quantitative characterization of mechanically indented in vivo human skin in adults and infants using optical coherence tomography

      Influenced by both the intrinsic viscoelasticity of the tissue constituents and the time-evolved redistribution of fluid within the tissue, the biomechanical response of skin can reflect not only localized pathology but also systemic physiology of an individual. While clinical diagnosis of skin pathologies typically relies on visual inspection and manual palpation, a more objective and quantitative approach for tissue characterization is highly desirable. Optical coherence tomography (OCT) is an interferometry-based imaging modality that enables in vivo assessment of cross-sectional tissue morphology with micron-scale resolution, which surpasses those of most standard clinical imaging tools, such as ultrasound imaging and magnetic resonance ...

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    16. A novel dermo-epidermal localization algorithm for swept source OCT images of human skin

      A novel dermo-epidermal localization algorithm for swept source OCT images of human skin

      Optical coherence tomography (OCT) is a noninvasive diagnostic method that offers a view into the superficial layers of the skin in vivo in real-time. OCT delivers morphological images of microstructures within the skin. Epidermal thickness in OCT images is of paramount importance, since dermo-epidermal junction (DEJ) location alteration is the start of several skin abnormalities. Due to the presence of speckle noise, devising an algorithm for locating DEJ in the OCT images is challenging. In this study we propose a semi-automatic DEJ detection algorithm based on graph theory that is resistant to speckle. In this novel approach we use attenuation ...

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    17. Textural analysis of optical coherence tomography skin images: quantitative differentiation between healthy and cancerous tissues

      Textural analysis of optical coherence tomography skin images: quantitative differentiation between healthy and cancerous tissues

      Optical Coherence Tomography (OCT) offers real-time high-resolution three-dimensional images of tissue microstructures. In this study, we used OCT skin images acquired from ten volunteers, neither of whom had any skin conditions addressing the features of their anatomic location. OCT segmented images are analyzed based on their optical properties (attenuation coefficient) and textural image features e.g., contrast, correlation, homogeneity, energy, entropy, etc. Utilizing the information and referring to their clinical insight, we aim to make a comprehensive computational model for the healthy skin. The derived parameters represent the OCT microstructural morphology and might provide biological information for generating an atlas ...

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    18. Vehicle type affects filling of fractional laser-ablated channels imaged by optical coherence tomography

      Vehicle type affects filling of fractional laser-ablated channels imaged by optical coherence tomography

      Ablative fractional laser (AFXL) is an emerging method that enhances topical drug delivery. Penetrating the skin in microscopic, vertical channels, termed microscopic treatment zones (MTZs), the fractional technique circumvents the skin barrier and allows increased uptake of topically applied drugs. This study aims to elucidate the impact of vehicle type on the filling of MTZs from application of liquid, gel, and cream vehicles. Ex vivo pig skin was exposed to 10,600 nm fractional CO 2 laser at 5% density, 120 μm beam diameter, and fluences of 40 and 80 mJ/microbeam (mJ/mb). Six repetitions were performed for each ...

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    19. Multi-beam optical coherence tomography for microvascular imaging of human skin in vivo

      Multi-beam optical coherence tomography for microvascular imaging of human skin in vivo

      In this paper, a multi-beam optical coherence tomography (OCT) was used to reconstruct the microvascular image of human skin in vivo with phase resolved Doppler OCT (PRDOCT), phase resolved Doppler variance (PRDV) and speckle variance OCT (svOCT), in which the blood flow image was calculated by averaging the four blood flow images obtained by the four beams. In PRDOCT method, it is difficult to detect the blood flow perpendicular to optical axis of the probe beam for single beam OCT, but the multi-beam scanning method can solve this because the input angles of the four probe beams are slightly different ...

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    20. Birefringence and vascular imaging of in vivo human skin by Jones-matrix optical coherence tomography

      Birefringence and vascular imaging of in vivo human skin by Jones-matrix optical coherence tomography

      A customized 1310-nm Jones-matrix optical coherence tomography (JM-OCT) for dermatological investigation was constructed and used for in vivo normal human skin tissue imaging. This system can simultaneously measure the threedimensional depth-resolved local birefringence, complex-correlation based OCT angiography (OCT-A), degree-ofpolarization- uniformity (DOPU) and scattering OCT intensity. By obtaining these optical properties of tissue, the morphology, vasculature, and collagen content of skin can be deduced and visualized. Structures in the deep layers of the epithelium were observed with depth-resolved local birefringence and polarization uniformity images. These results suggest high diagnostic and investigative potential of JM-OCT for dermatology.

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    21. Non-invasive skin imaging for the diagnosis of myiasis

      Non-invasive skin imaging for the diagnosis of myiasis

      A 52-year-old man presented with a painful ulceration of the scalp (Fig. 1a). He had returned from Guyana the previous week. Dermoscopic examination (FotoFinder Systems GmbH, Bad Birnbach, Germany) showed an intermittent dynamic aspect changing from a sanguineous roundish ulcer (Fig. 1b) to a peculiar roundish structure characterized by a yellowish peripheral ring and a central brownish part (Fig. 1c). High-definition optical coherence tomography (HD-OCT; Skintell ® ; Agfa Gevaert, Antverpen, Belgium) showed a skin cavity (Fig. 2a). Reflectance confocal microscopy (RCM; Vivascope 3000 ® , Caliber, New York, USA, distributed in Europe by MAVIG GmbH, München, Germany) showed the roundish structure observed ...

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      Mentions: AGFA Healthcare
    1-24 of 703 1 2 3 4 ... 28 29 30 »
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