Dermatology -Optical Coherence Tomography News

Articles in category: Dermatology

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1. Optical Coherence Tomography in Evaluation of Glomus Tumors: A Report of Three Cases
  
  Explore Wiley Online Library Apr 14 2019 Dermatology
  
  Glomus tumors are painful, benign perivascular neoplasms of the glomus body affecting the nail apparatus. Although diagnosis can be made clinically using Love's and Hildreth's tests, imaging is required to distinguish glomus tumors from other subungual vascular lesions. Clinical diagnosis is complicated when the nail has no visible abnormalities. 1 Magnetic resonance imaging (MRI) is the modality of choice for imaging but requires a dedicated small part coil, which is unavailable at some facilities and is costly. 2
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  Mentions: University of Miami Florida International University
2. High-accurate and robust fingerprint anti-spoofing system using Optical Coherence Tomography
  
  Explore ScienceDirect Apr 9 2019 Dermatology , Other Non-Medical
  
  Traditional commercial automated fingerprint recognition systems (AFRSs) are vulnerable to fake attacks by the use of artificial fingerprints, due to its limitation on resolution and the difficulty of obtaining depth information. Developing new systems with strong anti-spoofing ability are of increasing concern in the current digital age. Inspired by the observation and comparison of fingertip skin structure and the one dimensional (1D) depth signals derived from OCT acquisition images between real finger and artificial fingerprints, two novel anti-spoofing features, namely depth-double-peak feature and sub-single-peak feature, were specifically defined. Depth-double-peak feature refers that there must be two and only two peaks ...
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3. Researchers invent method to advance non-invasive melanoma identification using radiomic signatures
  
  Explore College of Engineering Apr 4 2019 Dermatology
  
  Biopsies have long been considered the diagnostic standard for melanoma, a globally worsening public health problem that has emerged as the deadliest form of skin cancer. Researchers have explored alternative ways to diagnose melanoma, using different imaging techniques to try and reduce the reliance on biopsies. “Performing biopsies can result in pain, anxiety, scarring and disfigurement for patients, as well as a considerable cost to the health care system,” said Mohammad Avanaki, assistant professor of biomedical engineering and director of the OPIRA Laboratory at Wayne State University. “However, imaging devices suffer from various drawbacks that result in limited specificity or ...
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  Mentions: Technical University of Denmark (DTU)
4. Noninvasive Determination of Epidermal and Stratum Corneum Thickness in vivo Using Two-Photon Microscopy and Optical Coherence Tomography: Impact of Body Area, Age, and Gender
  
  Explore Karger Publishers Mar 31 2019 Dermatology
  
  Background: High-resolution images of the epidermis are important to understand the transdermal penetration and changes in epidermal components. Both ex vivo and in vivo technologies are available to picture the epidermal thickness (ET). So far, the illustration of the stratum corneum (SC) has not been possible without artifacts. Objective: Precision in vivo measurement of the ET and SC, duly considering the impact of location on the body, age, and gender. Methods: In this pilot study on 20 skin-healthy subjects aged 18–66 years, the ET was imaged by two-photon microscopy (2PM) and optical coherence tomography (OCT), and the SC by ...
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5. The effect of melanin on in vivo optical coherence tomography of the skin in a multiethnic cohort
  
  Explore Wiley Online Library Mar 26 2019 Dermatology
  
  Background Noninvasive real‐time assessment of living tissue is quickly becoming invaluable for bolstering histologic and dermatoscopic measures of cutaneous conditions. While many skin researchers have explored the utility of noninvasive imaging in inflammatory and malignant skin conditions, there is yet to be a definitive and direct assessment of the effects of melanin on the quality of optical coherence tomography (OCT) imaging and its accuracy in multiethnic patient populations. We conducted a study to evaluate the effects of melanin on the quality of in vivo OCT imaging. Methods Volunteers of all Fitzpatrick skin types were imaged once in five skin ...
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  Mentions: Zhongping Chen UC Irvine
6. Evaluation of positive patch test reactions using optical coherence tomography: A pilot study
  
  Explore Wiley Online Library Mar 26 2019 Dermatology
  
  Introduction Patch testing is the gold standard for evaluating allergic contact dermatitis (ACD), yet current interpretation methods are limited by their subjectivity and possible variability between observers. Optical coherence tomography (OCT) imaging enables noninvasive in vivo skin visualization and holds promise as an objective method of patch test interpretation. Objective To evaluate the micromorphological changes of patch test reactions and identify objective, quantitative OCT markers that correlate with clinically graded patch test reactions. Results A total of 25 patch test reactions (7 grade‐0, 4 grade‐1+, 14 grade‐2+) from 7 patients underwent OCT evaluation. Increased epidermal thickness and ...
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  Mentions: University of Miami
7. The Use of Fractional Ablative CO2 Laser vs Control on Acute Traumatic Injuries to Prevent Scar Formation
  
  Explore Home - ClinicalTrials.gov Mar 25 2019 Dermatology , Clinical Trials
  
  Surgical standard for treating traumatic burn injury scarring is to wait one year following the initial assault prior to beginning treatment. This study investigates the use of fractional ablative CO2 laser when begun within 3 months of a traumatic burn injury and it's impact on scar formation compared to the control. We hypothesized that early intervention would substantially mitigate the formation of scar tissue and help restore more normal appearing skin.
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8. Melanoma Blood Vessel Changes Detected with OCT Imaging
  
  Explore Photonics.com Mar 25 2019 Dermatology , Oncology
  
  An international team of researchers has proven that dynamic optical coherence tomography (D-OCT) imaging of melanoma reveals changes to the blood vessels that correlate with the depth of its invasion, which could lead to a faster method of rapidly assessing the severity of a melanoma. Nathalie de Carvalho, of the University of Modena and Reggio Emilia, explained that cancers grow their own blood vessel network to supply oxygen and nutrients. “We analyzed the shapes of the vessels in the OCT images of melanomas and correlated the frequency of different shapes with the Breslow depths [the thickness of the tumors, measured ...
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9. Optical coherence tomography for diagnosis of BCC
  
  Explore Wiley Online Library Mar 21 2019 Dermatology
  
  Basal cell carcinoma (BCC) is the most common form of skin cancer in the world. Its incidence in Europe has increased at an alarming rate of 5.5% per year over the past four decades. In the U.K., the incidence of BCC has risen at a rate six times higher than in the rest of Europe. The diagnosis of BCC typically requires a biopsy of the skin and careful analysis under a microscope. Optical coherence tomography (OCT) is an imaging tool that uses light to visualize the layers underneath the skin surface in real‐time without the need to ...
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10. Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care Cream
  
  Explore Home - ClinicalTrials.gov Mar 18 2019 Dermatology , Clinical Trials
  
  In the realm of cosmetics, skin care accounts for a significant share accounting for 35.3% of the global market, creating a $121 billion industry. While many of the products claim to have unique, natural formulations that boost skin care, many products contain chemicals that are potentially damaging to skin. Such ingredients include preservatives, parabens, fragrances, and formaldehyde, which can cause skin irritation and inflammation. Although these ingredients help to preserve the stability and longevity of products, it is plausible to achieve efficacy and improve skin structure without risking unnecessary damage. The condition and health of the dermis rely largely ...
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11. Potential of contrast agents to enhance in vivo confocal microscopy and optical coherence tomography in dermatology: A review
  
  Explore Wiley Online Library Mar 14 2019 Dermatology
  
  Distinction between normal skin and pathology can be a diagnostic challenge. This systematic review summarizes how various contrast agents, either topically delivered, or injected into the skin affect distinction between skin disease and normal skin when imaged by optical coherence tomography (OCT) and confocal microscopy (CM). A systematic review of in vivo OCT and CM studies using exogenous contrast agents on healthy human skin or skin disease was performed. In total, 9 CM studies and 1 OCT study were eligible. Four contrast agents aluminum chloride (AlCl) n=2, indocyanin green (ICG) n=3, sodium fluorescein n=3 and acetic acid ...
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  Mentions: Mette Mogensen University of Copenhagen
12. Diagnostic Accuracy of Reflectance Confocal Microscopy for Diagnosis of Skin Lesions: An Update
  
  Explore archivesofpathology.org Mar 10 2019 Dermatology
  
  Context.— Histopathology is the current standard to diagnose skin disease. However, biopsy may not always be feasible, such as in patients with multiple nevi, a patient with a lesion on an aesthetically significant site, or in children. Recently, noninvasive techniques, including reflectance confocal microscopy (RCM), optical coherence tomography, and Raman spectroscopy, have enabled dermatologists to manage skin lesions in real time without the need for biopsy. Objective.— To report the updated diagnostic accuracy of RCM for equivocal skin lesions. Design.— In this study, we retrospectively reviewed our data of clinically suspicious lesions from 2010 to 2017 that were evaluated by ...
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13. Transfollicular delivery of gold microparticles in healthy skin and acne vulgaris, assessed by in vivo reflectance confocal microscopy and optical coherence tomography
  
  Explore Wiley Online Library Mar 9 2019 Dermatology
  
  Introduction Topical application of gold microparticles (GMPs) for selective photothermolysis is a recently FDA‐cleared therapy for acne vulgaris. Current evidence indicates the potential of optical imaging to non‐invasively visualize GMPs and describe photothermal tissue effects. Objectives To qualitatively and quantitatively describe GMP delivery in vivo and visualize laser‐mediated thermal effects of GMPs in facial skin of acne patients and healthy participants, using reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). Methods Patients with facial acne ( n = 14), and healthy participants ( n = 7) were included. RCM and OCT images were acquired at baseline, after GMP application, and ...
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  Mentions: Mette Mogensen University of Copenhagen
14. Nickel contact dermatitis evaluated by means of optical coherence tomography: first impressions
  
  Explore Wiley Online Library Mar 2 2019 Dermatology
  
  Nickel contact allergy, a major health problem in the general population, is usually diagnosed through appropriate clinical history and patch testing.(1, 2) Patch‐test results are not fully objectivable and are influenced by the observer's experience.(3) Moreover, not every individual with nickel‐sensitization develops a clinically visible contact allergy. We hypothesized that non‐invasive diagnostic techniques such as optical coherence tomography (OCT) could provide further details in interpreting patch‐tests and eventually detect subclinical changes in subjective reactions to known contact allergens.
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  Mentions: Ludwig Maximilian University of Munich
15. Can optical coherence tomography improve the management of basal cell carcinoma?
  
  Explore Wiley Online Library Mar 2 2019 Dermatology
  
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16. Real-time quantification of skin burns in external beam radiation therapy
  
  Explore uspto.gov Feb 26 2019 Dermatology , Patents
  
  A system for radiation therapy include an imaging device (108) configured to scan an area of interest for tissue undergoing radiation therapy to collect one or more images of the tissue. An interpretation module (110) is configured to receive the one or more images of the tissue to determine a burn status of the tissue and provide adjustments for a radiation treatment plan in accordance with the burn status.
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17. (Cost)-Effectiveness of OCT in BCC (ROCTI)
  
  Explore Home - ClinicalTrials.gov Feb 20 2019 Dermatology , Clinical Trials
  
  Skin cancer incidence rises worldwide due to high sun exposure and ageing. Basal cell carcinoma (BCC) is the most prevalent form, with a lifetime risk of 16-20% in the Netherlands. Currently, the gold standard for diagnosing and subtyping basal cell carcinoma (BCC) is a punch biopsy. Since this technique is invasive, new non-invasive diagnostic methods have been developed, including optical coherence tomography (OCT). In patients with clinical and dermoscopic suspicion of BCC, OCT makes it possible to confirm and subtype BCC with high confidence, thereby obviating the need for a punch biopsy in a substantial part of patients. Hence, BCC ...
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  Mentions: Academic Hospital Maastricht
18. Successful Utilization of Optical Coherence Tomography as a Non-Invasive, Bedside Imaging Technique To Identify Residual Nodular Basal Cell Carcinoma at Well-Healed and Clinically Unidentifiable Biopsy Site
  
  Explore jaad.org Feb 16 2019 Dermatology
  
  No abstract provided.
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  Mentions: Michelson Diagnostics Jon Holmes
19. Microvascular imaging of the skin
  
  Explore IOPscience Feb 7 2019 Dermatology
  
  Despite our understanding that the microvasculature plays a multifaceted role in the development and progression of various conditions, we know little about the extent of this involvement. A need exists for non-invasive, clinically meaningful imaging modalities capable of elucidating microvascular information to aid in our understanding of disease, and to aid in the diagnosis/monitoring of disease for more patient-specific care. In this review article, a number of imaging techniques are summarized that have been utilized to investigate the microvasculature of skin, along with their advantages, disadvantages and future perspectives in preclinical and clinical settings. These techniques include dermoscopy, capillaroscopy ...
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  Mentions: University of Washington Ruikang K. Wang
20. Optical coherence tomography array based subdermal imaging device
  
  Explore uspto.gov Feb 5 2019 Dermatology , Patents
  
  The invention teaches a multiple reference optical coherence tomography scanner that provides a subdermal fingerprint scan, covers an area of approximately 16 mm-17 mm.times.10 mm in less than a second, and fits into a slim profile of less than 6 mm in thickness, thereby fitting within the slim consumer electronics such as the iPhone and similar consumer electronics. Various embodiments are taught.
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21. Non‐invasive monitoring of subclinical and clinical actinic keratosis of face and scalp under topical treatment with ingenolmebutate gel 150 mcg/gby means of reflectance confocal microscopy and optical coherence tomography: new perspectives and comparison
  
  Explore Wiley Online Library Jan 28 2019 Dermatology
  
  Actinic keratosis (AKs) corresponds to the earliest stage of in‐situ squamous cell carcinoma and arises on chronically sun‐exposed skin. Around the clinically evident AKs, the apparently healthy epidermis may contain different grades of atypia that can be detected by non‐invasive imaging techniques such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). Subclinical actinic keratosis (sAKs) have captured increasing interest as a potential target of field therapies. The aim of this study was to evaluate in vivo the changes in the field cancerization undergoing treatment with topical ingenolmebutate by combining RCM and OCT. Twenty patients with ...
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22. Microneedle fractional radiofrequency‐induced micropores evaluated by in vivo reflectance confocal microscopy, optical coherence tomography, and histology
  
  Explore Wiley Online Library Jan 28 2019 Dermatology
  
  $Microneedle fractional radiofrequency‐induced micropores evaluated by in vivo reflectance confocal microscopy, optical coherence tomography, and histology$
  Background Microneedle fractional radiofrequency (MNRF) is a minimally invasive technique that delivers radiofrequency (RF) energy into the skin via microneedles. Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) enable the characterization of device‐tissue interactions in in vivo skin. The aim of this study is to describe MNRF‐induced micropores using RCM and OCT imaging. Materials and methods Five healthy participants were treated with a 7 × 7 array of 1500 μm microneedles on two adjacent areas of the right hip. One area received MNRF using high RF energy while the other underwent MNRF at low RF energy. Micropore morphology ...
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  Mentions: University of Copenhagen
23. Simultaneous dual-band line-field confocal optical coherence tomography: application to skin imaging
  
  Explore OSA | OSA Publishing Jan 28 2019 Dermatology
  
  Line-field confocal optical coherence tomography (LC-OCT) operating in two distinct spectral bands centered at 770 nm and 1250 nm is reported, using a single supercontinuum light source and two different line-scan cameras. B-scans are acquired simultaneously in the two bands at 4 frames per second. Greyscale representation and color fusion of the images are performed to either produce a single image with both high resolution (1.3 µm × 1.2 µm, lateral × axial, measured at the surface) in the superficial part of the image and deep penetration, or to highlight the spectroscopic properties of the sample. In vivo images of ...
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  Mentions: Arnaud Dubois
24. Dynamic Optical Coherence Tomography Is a New Technique for Imaging Skin Around Lower Extremity Wounds
  
  Explore SAGE Journals Jan 12 2019 Dermatology
  
  Chronic wounds such as venous leg ulcers invariably heal slowly and recur. In the case of venous leg ulcers, poor healing of chronic wounds is variously attributed to ambulatory hypertension, impaired perfusion and diffusion, presence of chronic inflammation at wound sites, lipodermatosclerosis, and senescence. The aim of this study was to investigate whether a new technique, optical coherence tomography (OCT), which permits imaging of blood capillaries in the peri-wound skin, can provide new insights into the pathology. OCT and its recent variant, dynamic OCT, permit rapid noninvasive depth-resolved imaging of the capillaries in the superficial dermis via a handheld probe ...
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  Mentions: Michelson Diagnostics University of Manchester Jon Holmes
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