1. Articles in category: Dermatology

    1-24 of 432 1 2 3 4 ... 16 17 18 »
    1. Modern non-invasive diagnostic techniques in the detection of early cutaneous melanoma

      Modern non-invasive diagnostic techniques in the detection of early cutaneous melanoma

      Over the past few years melanoma has grown into a disease of socio-economic importance due to the increasing incidence and persistently high mortality rates. Melanoma is a malignant tumor with a high tendency to metastasize. Therefore, an extremely important part of the therapeutic process is to identify the disease at an early stage: in situ or stage I. Many tools for early diagnosis of melanoma are available today, including dermoscopy, videodermoscopy and in vivo reflectance confocal microscopy. Other methods such as high frequency ultrasound, optical coherence tomography and electrical impedance spectroscopy may serve as additional diagnostic aids. Modern imaging techniques ...

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    2. Experimental research and observation of the skin response of mice with a second-degree scald duringirradiation by a CO 2 laser

      Experimental research and observation of the skin response of mice with a second-degree scald duringirradiation by a CO 2 laser

      Second-degree scalding is a common dermatological injury. Inappropriate treatment methods in clinical practice always produce scarring, and can lead to skin cancer and other complications in the longer term. In this study optical coherence tomography (OCT) combined with a skin detector was used to monitor the response of second-degree scalded skin tissue irradiated by a CO2 laser. The process of treatment of second-degree scalding was systematically studied from the perspective of tissue optics. The OCT signal intensity was stronger within the whole recovery period in the experimental group undergoing CO2 laser treatment, and the attenuation coefficient (μt) returned ...

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    3. Parallelized multi–graphics processing unit framework for high-speed Gabor-domain optical coherence microscopy

      Parallelized multi–graphics processing unit framework for high-speed Gabor-domain optical coherence microscopy

      Gabor-domain optical coherence microscopy (GD-OCM) is a volumetric high-resolution technique capable of acquiring three-dimensional (3-D) skin images with histological resolution. Real-time image processing is needed to enable GD-OCM imaging in a clinical setting. We present a parallelized and scalable multi-graphics processing unit (GPU) computing framework for real-time GD-OCM image processing. A parallelized control mechanism was developed to individually assign computation tasks to each of the GPUs. For each GPU, the optimal number of amplitude-scans (A-scans) to be processed in parallel was selected to maximize GPU memory usage and core throughput. We investigated five computing architectures for computational speed-up in processing ...

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    4. MedLumics Announces “BiopsyPen Project” with €3.6M EU in Funding; Initiative Aimed at New Clinical Applications for Optical Coherence Tomography

      MedLumics Announces “BiopsyPen Project” with €3.6M EU in Funding; Initiative Aimed at New Clinical Applications for Optical Coherence Tomography

      MedLumics , a medical imaging company specializing in advanced optical coherence tomography (OCT) technology, today announced the kick off of a three-year initiative to translate the latest OCT research into new clinical applications. Called the “BiopsyPen Project,” the effort is led by MedLumics and the Medical University of Vienna, with participation from a consortium of European members including VTT Finland, Delft University of Technology, Exalos AG, the Polytechnic University of Madrid, and Optocap Ltd. Together, the organizations are working to develop the second generation of a compact handheld diagnostic imaging system that will radically transform the capability of biophotonic technologies for ...

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    5. Spectroscopic study on appearances of make-up skins using a visible RGB-LED OCT

      Spectroscopic study on appearances of make-up skins using a visible RGB-LED OCT

      Background/purpose Facial foundation is very effective to correct color irregularities of the skin surface and to protect the skin from harmful light. This depends strongly on both the optical properties and the coating condition of foundation on the skin surface. Methods We constructed the full-field optical coherence tomography (OCT) (FF-OCT) microscope with visible light sources of RGB LEDs. The commercially available skin replicas were used as the model of skin in the experiment, which were composed of two layers, a thin polyurethane film transcribed from cheek surface of a female and a beige-colored silicone substrate. The foundations were applied ...

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    6. Positive top line results from clinical trial for diagnosis of basal cell carcinoma using VivoSight OCT

      Positive top line results from clinical trial for diagnosis of basal cell carcinoma using VivoSight OCT

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, announces positive top line results from the successfully completed multi-centre, prospective clinical trial for the diagnosis of basal cell carcinoma using VivoSight OCT. In the study, over 250 patients with clinically suspicious lesions for basal cell carcinoma were scanned at six centres in Germany. In each case, diagnosis using VivoSight OCT was compared with standard clinical diagnosis with and without dermoscopy. All results were verified by the gold standard of biopsy and histological analysis. Papers by Professor Dr. med. Julia Welzel, Dr. med. Martina ...

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    7. Positive results from multi-centre, prospective clinical trial for diagnosis of basal cell carcinoma using Michelson Diagnostics’ VivoSight OCT Presented at AAD

      Positive results from multi-centre, prospective clinical trial for diagnosis of basal cell carcinoma using Michelson Diagnostics’ VivoSight OCT Presented at AAD

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces positive results from the successfully completed multi-centre, prospective clinical trial for the diagnosis of basal cell carcinoma using VivoSight OCT to be presented at the upcoming American Academy of Dermatology’s 72nd Annual Meeting (AAD) in Denver, Colorado, 21-25 March 2014. Papers by Professor Dr. med. Julia Welzel, Dr. med. Martina Ulrich discussing results from the clinical study will be presented in the AAD Conference Session F153 “Non-Invasive Imaging in Dermatology” on Tuesday, 25 March at 1.00pm. The presented results support ...

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    8. Optical coherence tomography using images of hair structure and dyes penetrating into the hair

      Optical coherence tomography using images of hair structure and dyes penetrating into the hair

      Background/purpose Hair dyes are commonly evaluated by the appearance of the hair after dyeing. However, this approach cannot simultaneously assess how deep the dye has penetrated into hair. Methods For simultaneous assessment of the appearance and the interior of hair, we developed a visible-range red, green, and blue (RGB) (three primary colors)-optical coherence tomography (OCT) using an RGB LED light source. We then evaluated a phantom model based on the assumption that the sample's absorbability in the vertical direction affects the tomographic imaging. Results Consistent with theory, our device showed higher resolution than conventional OCT with far-red ...

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    9. Hydrogel-Forming Microneedles Increase in Volume During Swelling in Skin, but Skin Barrier Function Recovery is Unaffected

      Hydrogel-Forming Microneedles Increase in Volume During Swelling in Skin, but Skin Barrier Function Recovery is Unaffected

      We describe, for the first time, quantification of in-skin swelling and fluid uptake by hydrogel-forming microneedle (MN) arrays and skin barrier recovery in human volunteers. Such MN arrays, prepared from aqueous blends of hydrolyzed poly(methylvinylether/maleic anhydride) (15%, w/w) and the cross-linker poly(ethyleneglycol) 10,000 Da (7.5%, w/w), were inserted into the skin of human volunteers ( n = 15) to depths of approximately 300 μm by gentle hand pressure. The MN arrays swelled in skin, taking up skin interstitial fluid, such that their mass had increased by approximately 30% after 6 h in skin. Importantly, however ...

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    10. High resolution in-vivo imaging of skin with full field optical coherence tomography

      High resolution in-vivo imaging of skin with full field optical coherence tomography

      Full-field OCT (FFOCT) has the ability to provide en-face images with a very good axial sectioning as well as a very high transverse resolution (about 1 microns in all directions). Therefore it offers the possibility to visualize biological tissues with very high resolution both on the axial native view, and on vertical reconstructed sections. Here we investigated the potential dermatological applications of in-vivo skin imaging with FFOCT. A commercial FFOCT device was adapted for the in-vivo acquisition of stacks of images on the arm, hand and finger. Several subjects of different benign and pathological skin conditions were tested. The images ...

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    11. Michelson Diagnostics announces completion of data collection in Vivosight OCT trial for BCC diagnosis

      Michelson Diagnostics announces completion of data  collection in Vivosight OCT trial for BCC diagnosis

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces that it has completed scanning and data collection for a large 250-patient, multi-centre, prospective clinical trial of the diagnostic performance of its VivoSight™ OCT scanner in diagnosing superficial basal cell carcinoma (BCC), the most common form of skin cancer. Preliminary results from the trial are to be announced at the American Academy of Dermatology (AAD) Annual meeting in Denver, in March 2014. It is expected that full results will be published in a leading peer-reviewed journal later in the year. The study ...

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    12. Dermascope assisted interactive patient interface for multiple reference optical coherence tomography

      Dermascope assisted interactive patient interface for multiple reference optical coherence tomography

      There has been a growing interest in the development of a low cost depth-resolved non-invasive dermis imaging tool for both clinical and fundamental investigations of skin diseases. Multiple reference optical coherence tomography (MR-OCT) is a recently developed miniature time-domain low coherence interferometeric imaging platform, which promises to fit into robust, cost-effective designs that are virtually solid state, typical of handheld devices. In this paper we demonstrate the feasibility of MR-OCT for dermis imaging applications by incorporating it in a dermascope, which provides simultaneous imaging of dermis and an interactive tool for beam steering and registration of the OCT imaging beam ...

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    13. Motion tracking to enable pre-surgical margin mapping in basal cell carcinoma using optical imaging modalities: initial feasibility study using optical coherence tomography

      Motion tracking to enable pre-surgical margin mapping in basal cell carcinoma using optical imaging modalities: initial feasibility study using optical coherence tomography

      A system has been developed to assess the feasibility of using motion tracking to enable pre-surgical margin mapping of basal cell carcinoma (BCC) in the clinic using optical coherence tomography (OCT). This system consists of a commercial OCT imaging system (the VivoSight 1500, MDL Ltd., Orpington, UK), which has been adapted to incorporate a webcam and a single-sensor electromagnetic positional tracking module (the Flock of Birds, Ascension Technology Corp, Vermont, USA). A supporting software interface has also been developed which allows positional data to be captured and projected onto a 2D dermoscopic image in real-time. Initial results using a stationary ...

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    14. Continuous noninvasive monitoring of changes in human skin optical properties during oral intake of different sugars with optical coherence tomography

      Continuous noninvasive monitoring of changes in human skin optical properties during oral intake of different sugars with optical coherence tomography

      The objective of this study was to evaluate the effects of blood glucose concentration (BGC) on in vivo human skin optical properties after oral intake of different sugars. In vivo optical properties of human skin were measured with a spectral domain optical coherence tomography (SD-OCT). Experimental results show that increase of BGC causes a decrease in the skin attenuation coefficient. And the maximum decrements in mean attenuation coefficient of skin tissue after drinking glucose, sucrose and fructose solution are 47.0%, 36.4% and 16.5% compared with that after drinking water, respectively (p < 0.05). The results also show ...

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    15. High-definition optical coherence tomography and reflectance confocal microscopy in the in vivo visualization of a reaction to permanent make-up

      High-definition optical coherence tomography and reflectance confocal microscopy in the in vivo visualization of a reaction to permanent make-up

      Background and Objectives After permanent make-up treatments, eczematous and granulomatous reactions may occur which need anti-inflammatory treatment. For the definite diagnosis oftentimes biopsies are recommended. In vivo imaging such as reflectance confocal microscopy (RCM) and high-definition optical coherence tomography (HD-OCT) has been successfully used in the non-invasive diagnosis of various dermatoses before. Methods Here, we report on non-invasive imaging of a reaction towards permanent make-up in a 40-year-old woman by using HD-OCT and RCM. Results Both in HD-OCT and in RCM subepidermal pigment and granulomatous changes could be visualized and correlated with the histopathological findings. Regression of the lesions in ...

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      Mentions: AGFA Healthcare
    16. Correlation of optical coherence tomography and histology in microcystic adnexal carcinoma: a case report

      Correlation of optical coherence tomography and histology in microcystic adnexal carcinoma: a case report

      Background/Aims Herein, we report a case of microcystic adnexal carcinoma (MAC), which we correlated and evaluated by optical coherence tomography (OCT) and conventional H&E histology. Methods A commercially available OCT scanner was used for imaging. Several multi-slice images were obtained from the central portion of the lesion. Correlation of OCT findings with histology was performed retrospectively. Results Microcystic adnexal carcinoma showed characteristic criteria, which were divided into superficial and sub-epidermal findings. Conclusion The use of OCT can visualize characteristic criteria of MAC, thus enabling prompt diagnosis before surgery.

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    17. Michelson Diagnostics to launch enhanced software for VivoSight OCT scanner

      Michelson Diagnostics to launch enhanced software for  VivoSight OCT scanner

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces the launch of its upgraded VivoSight OCT scanner with a new software technology that provides additional features for dermatologists to investigate skin lesions such as non-melanoma skin cancer. The VivoSight OCT scanner enables the dermatologist to see vertical cross-sectional images of sub-surface skin tissue to depths of 1-1.5 mm in high definition, providing the clinician with important information about the type, depth and lateral spread of the skin lesion that is not possible to determine from its surface visual appearance. Our ...

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    18. In vivo enhancement of imaging depth for optical coherence tomography by eudermic agents on ridgedand meshed human skin

      In vivo enhancement of imaging depth for optical coherence tomography by eudermic agents on ridgedand meshed human skin

      Non-invasive skin analysis by optical coherence tomography (OCT) is limited because of the absorption and scattering properties of the tissue. There are several possibilities for enhancing OCT images. The purpose of this study was to demonstrate that image quality can be improved using the hyperosmolar agents glucose and glycerol while investigating human ridged and meshed skin areas, without causing damage to the tissue. The experiments were carried out on the palm and the forearm of ten volunteers. After application of the substances in the test area, the penetration depth and image contrast were measured at intervals of 5 min for ...

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    19. Michelson Diagnostics targets malignant melanoma using OCT imaging with €2.3M EU funding

      Michelson Diagnostics targets malignant melanoma using OCT imaging with €2.3M EU funding

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, announces that the European Union has awarded a €2.26 million Framework 7 grant to a consortium of seven partners, towards the cost of a project targeting malignant melanoma with OCT imaging. Using Michelson Diagnostics’ OCT imaging system, VivoSight, the project, named 'ADVANCE' (Automatic Detection of VAscular Networks for Cancer Evaluation), aims to demonstrate that multi-beam OCT imaging can be used to assess the aggressiveness of melanomas quickly and efficiently. Michelson Diagnostics is the lead partner in the ADVANCE project. Melanoma is the most ...

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    20. Nano-sensitive optical coherence tomography

      Nano-sensitive optical coherence tomography

      Depth resolved label-free detection of structural changes with nanoscale sensitivity is an outstanding problem in the biological and physical sciences and has significant applications in both the fundamental research and healthcare diagnostics arenas. Here we experimentally demonstrate a novel label-free depth resolved sensing technique based on optical coherence tomography (OCT) to detect structural changes at the nanoscale. Structural components of the 3D object, spectrally encoded in the remitted light, are transformed from the Fourier domain into each voxel of the 3D OCT image without compromising sensitivity. Spatial distribution of the nanoscale structural changes in the depth direction is visualized in ...

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    21. In vivo, high-resolution, three-dimensional imaging of port wine stain microvasculature in human skin

      In vivo, high-resolution, three-dimensional imaging of port wine stain microvasculature in human skin

      Port-wine stain (PWS) is a congenital, progressive vascular malformation of the dermis. In the past few years, advances in optical coherence tomography (OCT) technology have greatly increased imaging speed. Sophisticated numerical algorithms have improved the sensitivity of Doppler OCT dramatically. These improvements have enabled the noninvasive, high-resolution, three-dimensional functional imaging of PWS skin. In this study, high-resolution, three-dimensional, microvasculature imaging of PWS using Doppler OCT technique is demonstrated. Three-dimensional imaging of the subsurface vessel network of the dermis can provide information for accurate PWS classification and guidance for effective laser treatment. Invasive methods such as histology following biopsy and confocal ...

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    22. MedLumics Expands Management Team in Preparation for 2014 Launch of First Generation Diagnostic Imaging System for Dermatology

      MedLumics Expands Management Team in Preparation for 2014 Launch of First Generation Diagnostic Imaging System for Dermatology

      MedLumics, a medical imaging company specializing in advanced optical coherence tomography (OCT) technology , has announced the appointment of Miguel Eslava to the new position of vice president and chief operating officer. With more than a decade of senior management experience at GE Healthcare, Mr. Eslava brings significant business operations expertise to the company in advance of the anticipated launch of the first point-of-care diagnostic imaging system for dermatology in the second half of 2014. “We expect Miguel to play a critical role at MedLumics as we move from a research and development stage company to a commercial organization” “We expect ...

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    23. Imaging of Mohs Micrographic Surgery Sections Using Full-Field Optical Coherence Tomography: A Pilot Study

      Imaging of Mohs Micrographic Surgery Sections Using Full-Field Optical Coherence Tomography: A Pilot Study

      Background Full-field optical coherence tomography (FF-OCT) is a new noninvasive imaging technique that can see down to the cellular level without tissue preparation or contrast agents. Objective To use FF-OCT to image Mohs micrographic surgery specimens and verify the ability of a dermatopathologist to identify or exclude malignancy. Materials and Methods Two Mohs surgeons supplied 18 Mohs sections from 11 patients. Each section was scanned using the FF-OCT, and a dermatopathologist blinded to the diagnosis examined the images for malignancy. The FF-OCT images were then compared with the intraoperative hematoxylin and eosin (H&E)-stained frozen sections for concordance. Results ...

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    24. Michelson Diagnostics Announces £1.98 Million Financing

      Michelson Diagnostics Announces £1.98 Million Financing

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography ('OCT') technology, is delighted to announce the first closing of its Series A2 Financing. The round, which was oversubscribed, raised £1.98 million ( $3.25million ) from existing investors, led by Octopus Investments and supported by Catapult Venture Managers Ltd and London Business Angels, and several business angels. The funds will be used for several purposes including expanding VivoSight TM sales in Germany , where the system was launched in mid-2011 and where it is reimbursed for use in the diagnosis of non-melanoma skin cancer (NMSC), the commonest ...

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