Dermatology -Optical Coherence Tomography News

Articles in category: Dermatology

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1. New Non-invasive Techniques to Quantify Skin Surface Strain and Sub-surface Layer Deformation of Finger-pad during Sliding
  
  Explore ScienceDirect Jul 22 2017 Dermatology , Other Non-Medical
  
  tudies on the variation of skin properties with gender, age and anatomical region, with regards to interaction with different materials have resulted in significant research output. Investigations on skin surface strain and sub-surface layer deformation during sliding, however, have not received as much attention. This novel study uses two non-invasive techniques, optical coherence tomography (OCT) and digital image correlation (DIC), to measure properties of the index finger of a 25 year old female when under normal and shear loading. Measurements were taken during static, and for the first time, dynamic phases. It was observed that the number of ridges in ...
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  Mentions: University of Sheffield Steven J. Matcher
2. Michelson Diagnostics Secures CPT codes for Optical Coherence Tomography Imaging of Skin
  
  Explore Optical Coherence Tomography News Jul 13 2017 Dermatology , Other Business News
  
  Michelson Diagnostics announces that the American Medical Association (AMA) CPT Editorial Panel recently approved two new Category III CPT codes for Optical Coherence Tomography (OCT) imaging of skin. Code 0470T is for OCT microstructural and morphological imaging of skin, image acquisition, interpretation and report for a first lesion; code 0471T is the same for each additional lesion. The new Category III codes, which are for emerging technologies, services, and procedures, are effective July 1, 2017. Michelson Diagnostics pursued approval of this code at the AMA CPT Panel meeting in October 2017, receiving support from the American Academy of Dermatology. “Obtaining ...
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  Mentions: Michelson Diagnostics Jon Holmes FDA
3. Handheld optical coherence tomography–reflectance confocal microscopy probe for detection of basal cell carcinoma and delineation of margins
  
  Explore SPIE | Journal Jul 12 2017 Dermatology
  
  We present a hand-held implementation and preliminary evaluation of a combined optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) probe for detecting and delineating the margins of basal cell carcinomas (BCCs) in human skin in vivo . A standard OCT approach (spectrometer-based) with a central wavelength of 1310 nm and 0.11 numerical aperture (NA) was combined with a standard RCM approach (830-nm wavelength and 0.9 NA) into a common path hand-held probe. Cross-sectional OCT images and enface RCM images are simultaneously displayed, allowing for three-dimensional microscopic assessment of tumor morphology in real time. Depending on the subtype and ...
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  Mentions: Physical Sciences Incorporated Nicusor Iftimia
4. Monitoring skin trauma healing in mice using second-harmonic generation combined with optical coherence tomography
  
  Explore IEEE Xplore Jul 11 2017 Dermatology
  
  Convenient methods for rapidly evaluating wound healing could help clinicians to select effective treatment measures for patients within an appropriate time frame. In this study, we explored the use of second-harmonic generation (SHG) combined with optical coherence tomography (OCT) to monitor the healing state of wounds, including the macromorphology and optical signal characteristics of regenerated tissue. Wounds were imaged and monitored using OCT and SHG on healing days 3, 5, 7, 14, 21 and 28. The accumulation and maturation of newly formed collagen during the healing process was detected using SHG in real time. Additionally, changes in the OCT signal ...
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5. Suction blister lesions and epithelialization monitored by optical coherence tomography
  
  Explore Wiley Online Library Jul 7 2017 Dermatology
  
  Background/purpose Our objective was to assess epithelialization of suction blister lesions by optical coherence tomography (OCT) and benchmark it to histology using epidermal thickness (ET) as the primary outcome. Methods Thirty-two healthy volunteers were recruited to Study 1 and 2. One 10-mm suction blister was raised on each buttock, and the blister roof was excised. Lesions were covered with moisture-retaining dressing. In Study 1, the lesions were OCT-scanned on day 0 (D0), D2 and D4 and excised for histological examination. In Study 2, the progress of epithelialization and skin barrier function were monitored to D14. Results ET increased from ...
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  Mentions: Mette Mogensen
6. Automatic motion correction for in vivo human skin optical coherence tomography angiography through combined rigid and nonrigid registration
  
  Explore SPIE | Journal Jun 23 2017 Dermatology
  
  When using optical coherence tomography angiography (OCTA), the development of artifacts due to involuntary movements can severely compromise the visualization and subsequent quantitation of tissue microvasculatures. To correct such an occurrence, we propose a motion compensation method to eliminate artifacts from human skin OCTA by means of step-by-step rigid affine registration, rigid subpixel registration, and nonrigid B-spline registration. To accommodate this remedial process, OCTA is conducted using two matching all-depth volume scans. Affine transformation is first performed on the large vessels of the deep reticular dermis, and then the resulting affine parameters are applied to all-depth vasculatures with a further ...
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  Mentions: University of Washington Ruikang K. Wang
7. Association of Electrochemical Therapy With Optical, Mechanical, and Acoustic Impedance Properties of Porcine Skin
  
  Explore The JAMA Network Jun 22 2017 Dermatology
  
  Importance The classic management of burn scars and other injuries to the skin has largely relied on soft-tissue transfer to resurface damaged tissue with local tissue transfer or skin graft placement. In situ generation of electrochemical reactions using needle electrodes and an application of current may be a new approach to treat scars and skin. Objective To examine the changes in optical, mechanical, and acoustic impedance properties in porcine skin after electrochemical therapy. Design, Setting, and Participants This preclinical pilot study, performed from August 1, 2015, to November 1, 2016, investigated the effects of localized pH-driven electrochemical therapy of ex ...
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  Mentions: Zhongping Chen UC Irvine Brian J. F. Wong
8. Universal in vivo Textural Model for Human Skin based on Optical Coherence Tomograms
  
  Explore arxiv.org Jun 17 2017 Dermatology
  
  Currently, diagnosis of skin diseases is based primarily on visual pattern recognition skills and expertise of the physician observing the lesion. Even though dermatologists are trained to recognize patterns of morphology, it is still a subjective visual assessment. Tools for automated pattern recognition can provide objective information to support clinical decision-making. Noninvasive skin imaging techniques provide complementary information to the clinician. In recent years, optical coherence tomography has become a powerful skin imaging technique. According to specific functional needs, skin architecture varies across different parts of the body, as do the textural characteristics in OCT images. There is, therefore, a ...
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9. Optical Coherence Tomography Technology and Quality Improvement Methods for Optical Coherence Tomography Images of Skin: A Short Review
  
  Explore insights.sagepub.com Jun 17 2017 Dermatology
  
  Optical coherence tomography (OCT) delivers 3-dimensional images of tissue microstructures. Although OCT imaging offers a promising high-resolution method, OCT images experience some artifacts that lead to misapprehension of tissue structures. Speckle, intensity decay, and blurring are 3 major artifacts in OCT images. Speckle is due to the low coherent light source used in the configuration of OCT. Intensity decay is a deterioration of light with respect to depth, and blurring is the consequence of deficiencies of optical components. In this short review, we summarize some of the image enhancement algorithms for OCT images which address the above mentioned artifacts.
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10. Rapid ex vivo examination of Mohs specimens using optical coherence tomography
  
  Explore Photodiagnosis and Photodynamic Therapy Jun 17 2017 Dermatology
  
  Background Mohs micrographic surgery (MMS) is an effective treatment for certain non-melanoma skin cancers. Optical coherence tomography (OCT) is a biomedical imaging modality that permits high-resolution imaging of the epidermis and dermis with the potential to detect both healthy tissue and tumour. OCT may also provide a means of detecting and differentiating between the various histological subtypes of basal cell carcinomas (BCC) in vivo . Objective : The aim of this prospective ex vivo study was to evaluate the efficacy of OCT in recognising healthy and pathological margins of excised BCC lesions and detecting different BCC subtypes. Methods Seventy-three subjects with biopsy-proven ...
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  Mentions: Michelson Diagnostics Colin Hopper
11. Optical biopsy approach to basal cell carcinoma and melanoma based on all-optically integrated photoacoustic and optical coherence tomography
  
  Explore OSA | OSA Publishing Jun 3 2017 Dermatology
  
  Basal cell carcinoma (BCC) and melanoma (MM), with the highest morbidity and mortality, respectively, are considered as two skin cancers of concern in dermatology. Histological studies have demonstrated that vascular patterns and collagenous stroma serve as key parameters for BCC and MM classification. In this Letter, we sought to identify BCC and MM based on the dual parameters of vascular patterns and scattering structures provided by all-optically integrated photoacoustic and optical coherence tomography (AOPA/OCT). The imaging capability of the AOPA/OCT was verified by the mimic phantoms. Furthermore, in vivo characterization of vasculatures and tissue structures from BCC and ...
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  Mentions: South China Normal University
12. Measuring contact area in a sliding human finger-pad contact
  
  Explore Wiley Online Library Jun 2 2017 Dermatology
  
  Background/Purpose The work outlined in this paper was aimed at achieving further understanding of skin frictional behaviour by investigating the contact area between human finger-pads and flat surfaces. Methods Both the static and the dynamic contact areas (in macro- and micro-scales) were measured using various techniques, including ink printing, optical coherence tomography (OCT) and Digital Image Correlation (DIC). Results In the studies of the static measurements using ink printing, the experimental results showed that the apparent and the real contact area increased with load following a piecewise linear correlation function for a finger-pad in contact with paper sheets. Comparisons ...
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  Mentions: University of Sheffield Steven J. Matcher
13. Acne: morphologic and vascular study of lesions and surrounding skin by means of optical coherence tomography
  
  Explore Wiley Online Library May 30 2017 Dermatology
  
  Background Acne vulgaris is a disease of the pilosebaceous unit, characterized by hyper-keratinization process, comedos formation and inflammatory reactions. Objective The definition of the morphology and the vascularization of acne lesions by means of dynamic optical coherence tomography (D-OCT), in order to non-invasively define the alterations occurring during the acne development and patient therapeutic management. Methods A set of standardized clinical pictures and D-OCT images were acquired from 114 acne lesions of 31 volunteers, presenting mild to moderate acne and evaluated by experts. Fifteen patients treated with oral antibiotics were followed during time at 0, 20, 40, and 60 days ...
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14. Classification of Fingerprints Captured Using Optical Coherence Tomography
  
  Explore Home - Springer May 28 2017 Dermatology , Other Non-Medical
  
  We propose a technique for analysis of fingerprints scanned free-air (not pressed against a glass) with Optical Coherence Tomography (OCT). Fingerprints from the surface and subdermal parts of the finger are extracted from a 2 GB volumetric scan in cca. 2 s using our specialized technique and GPU acceleration on GeForce GTX 980. The technique provides fingerprints that perform with promising error rates that demonstrate the potential of the OCT for improved fingerprint identification, as well as its potential for prevention of biometric spoofing (PAD).
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15. Iron-oxide nanoparticles powered micro optical coherence tomography for in situ imaging the penetration and swelling of polymeric microneedles in skin
  
  Explore ACS Publications Home Page May 28 2017 Dermatology
  
  In recent years, polymeric microneedles (MNs) have attracted keen interests among researchers for their applicability in transdermal drug delivery and interstitial skin fluid (ISF) extraction. When design and characterize such devices, it is critical to monitor their real-time in vitro and in vivo performances to optimize the desired effects, yet most of the existing methods are incapable of such functions. To address this unmet need, we develop a real-time non-invasive imaging methodology by integrating iron oxide (Fe3O4) nanoparticles into polymeric MNs to enhance image contrast for micro-optical coherence tomography (µOCT) imaging. Using the Fe3O4 integrated polystyrene-block-poly (acrylic acid) (PS-b-PAA) MNs ...
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  Mentions: Linbo Liu
16. Freeze artifact on full-field optical coherence tomography skin imaging
  
  Explore Wiley Online Library May 24 2017 Dermatology
  
  Background/Purpose Full-field optical coherence tomography (FFOCT) is an emerging imaging technique for rapid histological analysis. As FFOCT is introduced into the Mohs workflow, it is important to document the effect of tissue freezing on FFOCT images and any effect FFOCT has on frozen sections. Our study aimed to evaluate the changes on FFOCT images after tissue freezing as well as FFOCT imaging effects on frozen sectioning. Methods Six normal skin specimens were imaged using FFOCT and subsequently frozen using a cryostat. The specimens were then reimaged using FFOCT and compared for any differences. To evaluate the effect of FFOCT ...
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17. Development and translation of label-free functional microscopy based on optical coherence tomography (Thesis)
  
  Explore DSpace@MIT May 16 2017 Dermatology , Student Theses
  
  Optical coherence tomography (OCT), an imaging modality based on low coherence interferometry, can be extended to obtain various endogenous functional contrasts. This thesis focuses on the development and translation of angiographic and polarization sensitive (PS) OCT techniques for clinical and preclinical applications. This goal includes four specific aims. The first aim is to develop a clinical imaging system to image the anatomy and microvasculature of human skin. The second aim is to develop a high performance post-processing algorithm for angiographic OCT. Towards this aim, we developed a processing algorithm based on complex differential variance (CDV) and confirmed its performance by ...
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  Mentions: Massachusetts Institute of Technology
18. In vivo microvascular imaging of cutaneous actinic keratosis, Bowen's disease and squamous cell carcinoma using Dynamic optical coherence tomography
  
  Explore Wiley Online Library May 14 2017 Dermatology
  
  Background A clear distinction between actinic keratosis (AK), Bowen's disease (BD) and squamous cell carcinoma (SCC) cannot reliably be made by clinical and dermoscopic evaluation alone. Dynamic optical coherence tomography (D-OCT) is a novel angiographic variant of OCT that allows for non-invasive, in vivo evaluation of the cutaneous microvascular morphology. Objective To investigate the microvascular structures of AK, BD and invasive SCC using D-OCT in order to gain insights into the microvascular morphology of lesions in the spectrum of keratinocyte skin cancers. Methods 47 patients with a total of 54 lesions (18 AK, 12 BD and 24 SCC) were ...
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  Mentions: Michelson Diagnostics Jon Holmes Gregor B. E. Jemec
19. Multimodal texture analysis of OCT images as a diagnostic application for skin tumors
  
  Explore jbpe.ssau.ru May 6 2017 Dermatology
  
  Optical coherence tomography (OCT) is an effective tool for determination of pathological topology that reflects structural and textural metamorphoses of tissue. In this paper, we propose a report about our examining of the validity of OCT in identifying changes using a skin cancer texture analysis compiled from Haralick texture features, fractal dimension, complex directional field features and Markov random field method from different tissues. The experimental data set contains 530 OCT images with normal skin and tumors as Basal Cell Carcinoma (BCC), Malignant Melanoma (MM) and Nevus. Speckle reduction is an essential pre-processing part for OCT image analyze. In this ...
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20. Damae Medical Raises €2M in Funding
  
  Explore Optical Coherence Tomography News Apr 29 2017 Dermatology , Funding , Other Business News
  
  Damae Medical , a Paris, France-based medtech company, closed a €2m funding. Backers included Kurma Partners, Idinvest Partners, News Invest, Paris-Saclay Seed Fund co-managed by Partech Ventures, and private investors. The company intends to use the funds to finance the development and CE marking of OCTAV®, which is scheduled for mid-2018. Founded in September 2014 by Anaïs Barut, CEO, Damae Medical aims to provide dermatologists with a novel, in vivo imaging technology for a deep look into the skin. This technology enables cellular-resolution imaging of the skin similar to histology, without the need for tissue excision and processing. The company ...
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  Mentions: Arnaud Dubois Damae Medical
21. Semi-automated localization of dermal epidermal junction in optical coherence tomography images of skin
  
  Explore OSA | OSA Publishing Apr 5 2017 Dermatology
  
  Identifying the location of the dermal epidermal junction (DEJ) in skin images is essential in several clinical applications of dermatology such as epidermal thickness determination in healthy versus unhealthy skins, such as basal cell carcinoma. Optical coherence tomography (OCT) facilitates the visual detection of DEJ in vivo . However, due to the granular texture of speckle and a low contrast between dermis and epidermis, a skin border detection method is required for DEJ localization. Current DEJ algorithms work well for skins with a visible differentiable epidermal layer but not for the skins of different body sites. In this paper, we present ...
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22. Delineating nonmelanoma skin cancer margins using terahertz and optical imaging
  
  Explore jbpe.ssau.ru Apr 4 2017 Dermatology
  
  We evaluated terahertz reflectance imaging and a combination of terahertz and optical techniques for delineating nonmelanoma skin cancers. After imaging, each terahertz pixel of each specimen was classified as cancerous or normal using a previously determined threshold. Subsequently, cancerous terahertz pixels were re-evaluated with polarization-sensitive optical technique. This additional information enabled us to re-classify each cancerous terahertz pixel using morphological appearance of the structures in the optical images. If the structures in the terahertz pixel appeared normal, the pixel was considered normal. The generalized linear mixture model was implemented to determine the sensitivity and specificity of each method. The model ...
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23. Monte-Carlo simulation of OCT structural images of human skin using experimental B-scans and voxel based approach to optical properties distribution
  
  Explore Conference Proceedings Mar 30 2017 Dermatology
  
  A method of optical coherence tomography (OCT) structural images reconstruction using Monte Carlo simulations is described. Biological object is considered as a set of 3D elements that allow simulation of media, structure of which cannot be described analytically. Each voxel is characterized by its refractive index and anisotropy parameter, scattering and absorption coefficients. B-scans of the inner structure are used to reconstruct a simulated image instead of analytical representation of the boundary geometry. Henye-Greenstein scattering function, Beer-Lambert-Bouguer law and Fresnel equations are used for photon transport description. Efficiency of the described technique is checked by the comparison of the simulated ...
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  Mentions: Sergey G. Proskurin
24. Intraoperative 4-Dimensional Microscope-Integrated Optical Coherence TomographyGuided 27-Gauge Transvitreal Choroidal Biopsy for Choroidal Melanoma
  
  Explore LWW Online Mar 24 2017 Dermatology , Microscopy , Oncology , Ophthalmology
  
  Tissue sampling is desireable to understand prognostic genetic alternations in uveal melanoma...
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  Mentions: Joseph A. Izatt Duke University Cynthia A. Toth
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