1. Articles in category: Dermatology

    1-24 of 461 1 2 3 4 ... 18 19 20 »
    1. Future Prospects in Dermatologic Applications of Lasers, Nanotechnology, and Other New Technologies

      Future Prospects in Dermatologic Applications of Lasers, Nanotechnology, and Other New Technologies

      We review novel technologies with diagnostic and therapeutic applications in dermatology. Among the diagnostic techniques that promise to become part of dermatologic practice in the future are optical coherence tomography, multiphoton laser scanning microscopy, Raman spectroscopy, thermography, and 7-T magnetic resonance imaging. Advances in therapy include novel light-based treatments, such as those applying lasers to new targets and in new wavelengths. Devices for home therapy are also appearing. We comment on the therapeutic uses of plasma, ultrasound, radiofrequency energy, total reflection amplification of spontaneous emission of radiation, light stimulation, and transepidermal drug delivery. Finally, we mention some basic developments in ...

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    2. Differentiating allergic and irritant contact dermatitis by high-definition optical coherence tomography: a pilot study

      Differentiating allergic and irritant contact dermatitis by high-definition optical coherence tomography: a pilot study

      Differentiation of allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD) is important because of different management requirements. Various non-invasive tests have been used in an attempt to improve diagnosis. In irritant dermatitis, thickening of the epidermis has been a constant finding. High-Definition Optical Coherence Tomography (HD-OCT) is a non-invasive real-time three-dimensional imaging technique with cellular resolution for which an adapted algorithmic method for pattern analysis discriminating inflammatory skin diseases has been proposed. The aim of this study was threefold. (1) To evaluate the correlation between HD-OCT features and clinical scores of allergic and irritant patch test reactions. (2) To ...

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    3. Imaging of collagen deposition disorders using optical coherence tomography

      Imaging of collagen deposition disorders using optical coherence tomography

      Background Collagen deposition disorders such as hypertrophic scars, keloids and scleroderma can be associated with significant stigma and embarrassment. These disorders often constitute considerable impairment to quality of life, with treatment posing to be a substantial challenge. Optical coherence tomography (OCT) provides a non-invasive, easily applicable bedside optical imaging method for assessment of the skin. It is hypothesized that OCT imaging may be useful in assessing fibrosis to avoid additional biopsies that could potentially worsen the scarring. Method Thirty-three patients with ordinary scars, hypertrophic scars, keloid scarring, lichen sclerosus et atrophicus and localized or systemic scleroderma were recruited for this ...

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    4. Functional optical coherence tomography of pigmented lesions

      Functional optical coherence tomography of pigmented lesions

      Background Cutaneous melanomas are diagnosed worldwide in 231 130 patients per year. The sensitivity and specificity of melanoma diagnosis expresses the need for an additional diagnostic method. Optical coherence tomography (OCT) has shown that it allows morphological (qualitative) description of image features and quantitative analysis of pathology related light scattering by means of the attenuation coefficient (μ oct ). Objective We hypothesize that OCT images of nevi will differ qualitatively and quantitatively from melanomas. Methods Forty lesions from 33 consecutive patients were imaged with OCT. After data acquisition, excision was performed. Epidermal layer thickness was measured and values of μ oct were extracted ...

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    5. Volumetric cutaneous microangiography of human skin in vivo by VCSEL swept-source optical coherence tomography

      Volumetric cutaneous microangiography of human skin in vivo by VCSEL swept-source optical coherence tomography

      We demonstrate volumetric cutaneous microangiography of the human skin in vivo that utilises 1.3-μm high-speed sweptsource optical coherence tomography (SS-OCT). The swept source is based on a micro-electro-mechanical (MEMS)-tunable vertical cavity surface emission laser (VCSEL) that is advantageous in terms of long coherence length over 50 mm and 100 nm spectral bandwidth, which enables the visualisation of microstructures within a few mm from the skin surface. We show that the skin microvasculature can be delineated in 3D SS-OCT images using ultrahigh-sensitive optical microangiography (UHS-OMAG) with a correlation mapping mask, providing a contrast enhanced blood perfusion map with ...

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    6. High-Definition Optical Coherence Tomography in the Diagnosis of Basal Cell Carcinoma Evaluated by an Experienced Versus Inexperienced Investigator

      High-Definition Optical Coherence Tomography in the Diagnosis of  Basal Cell Carcinoma Evaluated by an Experienced Versus Inexperienced  Investigator

      Background: Histopathology is the gold standard in the diagnosis of basal cell carcinoma (BCC) but biopsies are invasive and often not the preferred diagnostic method for patients. In this context, non-invasive diagnostic imaging tools such as high definition optical coherence tomography (HD-OCT) have shown promising results in diagnosing BCC in real time, atraumatically and repeatedly. Objective: To evaluate the sensitivity and specificity of HD-OCT in the diagnosis of BCC by an experienced versus an inexperienced investigator and describe typical features in common differential diagnosis of BCC. Patients and methods: Forty three patients with clinical suspicion for BCC were included. The ...

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    7. Histogram flow mapping with optical coherence tomography for in vivo skin angiography of hereditary hemorrhagic telangiectasia

      Histogram flow mapping with optical coherence tomography for in vivo skin angiography of hereditary hemorrhagic telangiectasia

      Speckle statistics of flowing scatterers have been well documented in the literature. Speckle variance optical coherence tomography exploits the large variance values of intensity changes in time caused mainly by the random backscattering of light resulting from translational activity of red blood cells to map out the microvascular networks. A method to map out the microvasculature malformation of skin based on the time-domain histograms of individual pixels is presented with results obtained from both normal skin and skin containing vascular malformation. Results demonstrated that this method can potentially map out deeper blood vessels and enhance the visualization of microvasculature in ...

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    8. Optical characterization of facial foundation applied to skin replicas by using visible FF-OCT

      Optical characterization of facial foundation applied to skin replicas by using visible FF-OCT

      We have developed a new type of optical coherence tomography using visible-LED sources to investigate light propagation in a make-up skin and measure the thickness of facial foundation. The thickness is estimated by the difference between the three-dimensional tomographic images of a skin replica before and after applying facial foundation. Finally, we demonstrate experimentally that this work is the first step to investigate the relation between the appearance and the light propagation in the make-up

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    9. Full-depth epidermis tomography using a Mirau-based full-field optical coherence tomography

      Full-depth epidermis tomography using a Mirau-based full-field optical coherence tomography

      With a Gaussian-like broadband light source from high brightness Ce 3+ :YAG single-clad crystal fiber, a full-field optical coherence tomography using a home-designed Mirau objective realized high quality images of in vivo and excised skin tissues. With a 40 × silicone-oil-immersion Mirau objective, the achieved spatial resolutions in axial and lateral directions were 0.9 and 0.51 μm, respectively. Such a high spatial resolution enables the separation of lamellar structure of the full epidermis in both the cross-sectional and en face planes. The number of layers of stratum corneum and its thickness were quantitatively measured. This label free and non-invasive ...

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    10. Dermascope guided multiple reference optical coherence tomography

      Dermascope guided multiple reference optical coherence tomography

      In this paper, we report the feasibility of integrating a novel low cost optical coherence tomography (OCT) system with a dermascope for point-of-care applications. The proposed OCT system is based on an enhanced time-domain optical coherence tomographic system, called multiple reference OCT (MR-OCT), which uses a single miniature voice coil actuator and a partial mirror for extending the axial scan range. The system can simultaneously register both the superficial dermascope image and the depth-resolved OCT sub-surface information by an interactive beam steering method. A practitioner is able to obtain the depth resolved information of the point of interest by simply ...

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    11. Treatment monitoring of topical ingenol mebutate in actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy: a case series

      Treatment monitoring of topical ingenol mebutate in actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy: a case series

      ingenol mebutate gel has been approved lately for the topical treatment of actinic keratoses (AK). Modern imaging techniques such as optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) have been shown useful for the non-invasive diagnostics of non-melanoma skin cancer 1-6 . Both techniques differ in optical resolution and penetration depth.

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      Mentions: Tanja Maier
    12. A multicentre pilot study investigating high-definition optical coherence tomography in the differentiation of cutaneous melanoma and melanocytic naevi

      A multicentre pilot study investigating high-definition optical coherence tomography in the differentiation of cutaneous melanoma and melanocytic naevi

      Background High-definition optical coherence tomography scanners have recently been developed. Objectives To assess the diagnostic performance of HD-OCT in the differentiation of benign melanocytic skin lesions (MSL) and cutaneous melanoma (CM). Methods Patients with MSL were assessed by HD-OCT. All diagnoses were histopathologically confirmed. One blinded observer evaluated both slice and en-face HD-OCT images and diagnosed MLS on the basis of an algorithm adopted from reflectance confocal microscopy, recent HD-OCT reports, and conventional OCT. Results A total of 93 MSL were studied comprising 66 benign MSL and 27 CM. The sensitivity of HD-OCT was 74.1% [95% confidence interval (CI ...

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    13. Optical coherence tomography applied to tests of skin care products in humans – a case study

      Optical coherence tomography applied to tests of skin care products in humans – a case study

      Background/purpose When evaluating skin care products for human skin, quantitative test methods need to be simple, precise and reliable. Optical coherence tomography (OCT), provides high-resolution sectional images of translucent materials to a depth of a few millimeters, a technique usually applied to medical measurements in ophthalmology and dermatology. This study aimed to demonstrate the application of OCT as the main technique for monitoring changes in skin topography during tests of a wrinkle-reduction product in humans. Methods We used a commercial OCT apparatus to perform clinical examinations of skin roughness in treated and non-treated sites in the periorbital region of ...

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      Mentions: Marcus P. Raele
    14. Real-time three-dimensional imaging of epidermal splitting and removal by high-definition optical coherence tomography

      Real-time three-dimensional imaging of epidermal splitting and removal by high-definition optical coherence tomography

      Background While real-time 3-D evaluation of human skin constructs is needed, only 2-D non-invasive imaging techniques are available. Objective Evaluation of the potential of High-Definition Optical Coherence Tomography (HD-OCT) for real-time 3-D assessment of the epidermal splitting and de-cellularisation. Methods Human skin samples were incubated with four different agents: Dispase II, NaCl 1M, Sodium Dodecyl Sulfate (SDS) and Triton X-100. Epidermal splitting, dermo-epidermal junction, acellularity and 3-D architecture of dermal matrices were evaluated by High-Definition Optical Coherence Tomography before and after incubation. Real-time 3-D HD-OCT assessment was compared with 2-D en face assessment by Reflectance Confocal Microscopy (RCM). (Immuno)histopathology ...

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    15. Applying RGB LED in full-field optical coherence tomography for real-time full-color tissue imaging

      Applying RGB LED in full-field optical coherence tomography for real-time full-color tissue imaging

      A conventional handheld skin camera is suitable for 2D inspection of shallow skin. Due to its high resolution and noninvasiveness, optical coherence tomography (OCT) has become a popular medical-imaging technology. Among OCT schemes, full-field optical coherence tomography (FF-OCT) is suitable for rapid en face imaging, as it uses a 2D imaging device for pixel processing of a sample plane. Because of its wide bandwidth and long lifetime, an RGB LED was chosen in an FF-OCT system among three source candidates in this study. A full-color tissue image and real-time video were obtained from the system to demonstrate the potential of ...

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    16. Michelson Diagnostics to present at Fortbildungswoche, Munich

      Michelson Diagnostics to present at Fortbildungswoche, Munich

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces that leading experts in the use of optical technology in dermatology will be presenting the benefits of multi-beam OCT at the 24th Annual Education Week for Practical Dermatology and Venereology, known as Fortbildungswoche, in Munich, Germany, 19-25 July 2014. The conference session on ‘Evidence for OCT diagnostics’ will take place at 12:15-13:15, Forum 9, on Friday 25th July. The presentations include: Optical coherence tomography scientific fundamentals and applications, Dr. Martina Ulrich Optical coherence tomography for basal cell carcinoma, Prof. Dr ...

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    17. Optical coherence tomography imaging of erythematotelangiectatic rosacea during treatment with brimonidine topical gel 0.33%: a potential method for treatment outcome assessment

      Optical coherence tomography imaging of erythematotelangiectatic rosacea during treatment with brimonidine topical gel 0.33%: a potential method for treatment outcome assessment

      BACKGROUND: Patients with moderate to severe rosacea often seek treatment to reduce erythema and vascular markings. Few studies have looked at the effectiveness of the novel treatment, brimonidine topical gel 0.33%, trademark name Mirvaso®, in the treatment of rosacea. We report the use of optical coherence tomography (OCT) scanning to monitor the effectiveness of Mirvaso® on in vivo skin. OCT is a non-invasive optical imaging technique that can provide high-resolution imaging of vessel and cellular morphology. OCT may be useful as a pre-treatment assessment tool for identifying possible morphologic features in the skin that may serve as outcome predictors ...

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    18. Doppler optical coherence tomography for microcirculation studies (Thesis)

      Doppler optical coherence tomography for microcirculation studies (Thesis)

      This thesis forms part of an ongoing long-term project to investigate the suitability of Doppler optical coherence tomography (OCT) as a measurement tool to investigate skin thickness and blood flow in patients with systemic sclerosis. There is a discussion of the characterisation of an electro-optic phase modulator for use in a Doppler OCT imaging system which is being built for the purpose of clinical studies. In addition to this the development of software for the same system is described. The work includes a comparison of two methods of obtaining Doppler information that were tested with the system; a phase resolved ...

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    19. Noninvasive monitoring of basal cell carcinomas treated with systemic hedgehog inhibitors: Pseudocysts as a sign of tumor regression

      Noninvasive monitoring of basal cell carcinomas treated with systemic hedgehog inhibitors: Pseudocysts as a sign of tumor regression

      Background Oral hedgehog inhibitors (HHIs) have shown significant efficacy in the treatment of basal cell carcinoma (BCC). The evaluation of tumor regression has been performed using clinical photography and radiographic scans. Noninvasive imaging techniques, such as reflectance confocal microscopy (RCM) and high-definition optical coherence tomography (HD-OCT), have been shown to be valuable in detecting BCC in the skin. Objective We monitored HHI-treated BCC using RCM and HD-OCT in vivo and correlated morphologic changes seen on imaging to changes in traditional histopathology. Methods Six BCCs in 5 patients receiving HHIs (vismodegib or sonidegib) were examined by RCM and HD-OCT before and ...

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    20. Feature Of The Week 6/8/14: Automated Registration of OCT and Dermoscopy in the Assessment in Basal Cell Carcinoma

      Feature Of The Week 6/8/14: Automated Registration of OCT and Dermoscopy in the Assessment in Basal Cell Carcinoma

      Optical coherence tomography (OCT) has been shown to be of clinical value in imaging basal cell carcinoma (BCC). A novel dual OCT-video imaging system, providing automated registration of OCT and dermoscopy, has been developed to assess the potential of OCT in measuring the degree of sub-clinical spread of BCC. Seventeen patients selected for Mohs micrographic surgery (MMS) for BCC were recruited to the study. The extent of BCC infiltration beyond a segment of the clinically assessed pre-surgical border was evaluated using OCT. Sufficiently accurate (<0.5 mm) registration of OCT and dermoscopy images was achieved in 9 patients. The location ...

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    21. Sun protection and hydration of stratum corneum: a study by 2D differential method

      Sun protection and hydration of stratum corneum: a study by 2D differential method

      The stratum corneum (written SC in the following) is the outermost layer of the epidermis and serves as a barrier against environmental aggression, such as infection, dehydration or sun damages. Within the SC, death cells called corneocytes, linked by an intercellular bridge called desmosomes, form layers. Depending on the body part and environmental factors, the number of layers and the thickness of each one can vary.

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    22. High frequency ultrasonography but not 930nm-optical coherence tomography reliably evaluates melanoma thickness in vivo: a prospective validation study.

      High frequency ultrasonography but not 930nm-optical coherence tomography reliably evaluates melanoma thickness in vivo: a prospective validation study.

      Background Early diagnosis and rapid surgical excision are essential for improving the prognosis of melanoma patients. Reflectance confocal microscopy has been validated as a feasible procedure for in vivo diagnosis of melanoma but cannot be used to measure tumour thickness. However, ultrasonography and optical coherence tomography may allow melanoma thickness to be measured in vivo . Objectives Primary: To validate the accuracy and reliability of high-frequency ultrasonography and optical coherence tomography for assessing melanoma thickness in vivo . Methods We conducted a prospective study on 131 patients with at least one equivocal melanocytic lesion. Each lesion underwent optical coherence tomography and high-frequency ...

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    23. OCT Developments Address Skin

      OCT Developments Address Skin

      Recent developments in optical coherence tomography (OCT) address skin cancer diagnosis. MedLumics (Madrid, Spain) has launched a three-year initiative to translate research into new clinical applications—with help from $4.9 million (€3.6 million) in Series A funding from EU joint investors. Called the BiopsyPen Project, the initiative is led by MedLumics and the Medical University of Vienna (Austria), along with European members including VTT Finland (Espoo, Finland), Delft University of Technology in The Netherlands, Exalos (Schlieren, Switzerland), the Polytechnic University of Madrid, and Optocap (Livingston, Scotland). The organizations are working to develop a handheld system for point-of-care diagnosis ...

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    24. Characterization of Optical Coherence Tomography Images Acquired at Large Distances With Large-Diameter Beams

      Characterization of Optical Coherence Tomography Images Acquired at Large Distances With Large-Diameter Beams

      We tested the imaging capabilities for variants of a 1550-nm swept-source fiber-based optical coherence tomography system with a telecentric system incorporated at the end of its sample arm. The system was designed for in vivo imaging of burns; therefore, we acquired images from samples located at distances greater than 24 cm from the exit of the telecentric system. Each system variation had a specific combination of diameters for the reference and sample beams. In the reference arm, we used, alternately, two collimated beams with diameters of 1.5 and 14 mm, respectively. In the sample arm, we tested collimated beams ...

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    1-24 of 461 1 2 3 4 ... 18 19 20 »
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