1. Articles in category: Dermatology

    1-24 of 579 1 2 3 4 ... 23 24 25 »
    1. Real-time quantitation of internal metabolic activity of three-dimensional engineered tissues using an oxygen microelectrode and optical coherence tomography

      Real-time quantitation of internal metabolic activity of three-dimensional engineered tissues using an oxygen microelectrode and optical coherence tomography

      Recent progress in tissue engineering technology has enabled us to develop thick tissue constructs that can then be transplanted in regenerative therapies. In clinical situations, it is vital that the engineered tissues to be implanted are safe and functional before use. However, there is currently a limited number of studies on real-time quality evaluation of thick living tissue constructs. Here we developed a system for quantifying the internal activities of engineered tissues, from which we can evaluate its quality in real-time. The evaluation was achieved by measuring oxygen concentration profiles made along the vertical axis and the thickness of the ...

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      Mentions: Osaka University
    2. Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer

      Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer

      Purpose To compare the diagnostic imaging ability of three different optical coherence tomography (OCT) devices in non-melanoma skin cancer (NMSC). Methods Thirty actinic keratoses (AKs) and 27 basal cell carcinomas (BCCs) of 29 patients were examined with three different OCT devices, VivoSight ® , Callisto ® and Skintell ® . Results Complete data sets were available for 16 BCCs and 10 AKs of 18 patients. All OCT devices were able to discriminate BCCs and AKs significantly from perilesional normal skin due to lower signal intensities as well as a thicker stratum corneum and epidermis in AKs. A significant decrease in the signal intensity and thickness ...

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    3. Non-invasive diagnostic techniques in the diagnosis of squamous cell carcinoma

      Non-invasive diagnostic techniques in the diagnosis of squamous cell carcinoma

      Squamous cell carcinoma is the second most common cutaneous malignancy after basal cell carcinoma. Although the gold standard of diagnosis for squamous cell carcinoma is biopsy followed by histopathology evaluation, optical non-invasive diagnostic tools have obtained increased attention. Dermoscopy has become one of the basic diagnostic methods in clinical practice. The most common dermoscopic features of squamous cell carcinoma include clustered vascular pattern, glomerular vessels and hyperkeratosis. Under reflectance confocal microscopy, squamous cell carcinoma shows an atypical honeycomb or disarranged pattern of the spinous-granular layer of the epidermis, round nucleated bright cells in the epidermis and round vessels in the ...

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    4. Optical coherence tomography to evaluate the effects of oxidative hair dye on the fiber

      Optical coherence tomography to evaluate the effects of oxidative hair dye on the fiber

      Background/purpose Oxidative hair dyes can damage the hair, since these chemical procedures are involved to change the fiber structure and therefore changes in their mechanical and surface properties. Evaluate and compare the effect of the two colors of oxidative hair dye emulsions on Caucasian hair. This research analyzed the Dark brown hair untreated ( I ); Dark brown hair treated with light brown dye ( II ); Dark brown hair treated with light blond dye ( III ); Light blond hair untreated ( IV ); Light blond hair treated with light brown dye ( V ); Light blond hair treated with light blond dye ( VI ) on Caucasian hair. Methods ...

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    5. Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study

      Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study

      We present a combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) approach, integrated within a single optical layout, for diagnosis of basal cell carcinomas (BCCs) and delineation of margins. While RCM imaging detects BCC presence (diagnoses) and its lateral spreading (margins) with measured resolution of ∼ 1    μ m ∼1  μm , OCT imaging delineates BCC depth spreading (margins) with resolution of ∼ 7    μ m ∼7  μm . When delineating margins in 20 specimens of superficial and nodular BCCs, depth could be reliably determined down to ∼600    μ m ∼600  μm , and agreement with histology was within about ±50    μ m ±50  μm .

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    6. In vivo and in situ imaging of controlled-release dissolving silk microneedles into the skin by optical coherence tomography

      In vivo and in situ imaging of controlled-release dissolving silk microneedles into the skin by optical coherence tomography

      Nowadays, transdermal drug delivery has become a hot topic with regard to delivery. Also, the percutaneous microneedle patch made of water-soluble material makes this technique one step closer to clinical application. The process of the microneedle patch penetrates and dissolves in the animal skin can directly reflect the efficiency of drug delivery. Hence, it is important to reflect the situation of microneedles dissolution and drug release by in vivo and in situ imaging in real time. This paper's purpose is to use the means of OCT (optical coherence tomography) to realize assessment of dissolving microneedles delivery efficiency in vivo ...

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    7. 3D printing-assisted fabrication of double-layered optical tissue phantoms for laser tattoo treatments

      3D printing-assisted fabrication of double-layered optical tissue phantoms for laser tattoo treatments

      Background and Objective Artificial skin phantoms have been developed as an alternative tissue for human skin experiments due to convenient use and easy storage. However, fabricating both thin (∼100 μm) epidermis and relatively thick dermis is often cumbersome, and most developed phantoms have hardly reflected specific human skin types. The objective of this study was to fabricate skin phantoms with 3D printing technique to emulate various human skin types (I–VI) along with the corresponding optical and mechanical properties for laser tattoo removal. Study Design/Materials and Methods Both gelatin and agar powders were mixed with coffee and TiO 2 ...

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    8. Skin Cancer Biopsied by Optical Scan

      Skin Cancer Biopsied by Optical Scan

      Apollo Medical Optics Inc. (Taipei, Taiwan) aims to revolutionize skin cancer detection without the need for invasive biopsies by using a single-crystal sapphire and yttrium aluminium garnet crystalline fibers—surrounded by glass and a flexible polymer cladding—to look-through the skin and image suspicious skin anomalies non-invasively, instead of taking a skin sample and risk releasing malignant cancer cells into the bloodstream. The current prototype, using single-crystal sapphire at its core, is being integrated into a desktop unit that physicians can use in the office to identify skin cancer in a matter of minutes, determine its size and if small ...

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    9. Fingerprint Matching with Optical Coherence Tomography

      Fingerprint Matching with Optical Coherence Tomography

      Fingerprint recognition is an important security technique with a steadily growing usage for the identification and verification of individuals. However, current fingerprint acquisition systems have certain disadvantages, which include the requirements of physical contact with the acquisition device, and the presence of undesirable artefacts, such as scars, on the surface of the fingerprint. This paper evaluates the accuracy of a complete framework for the capturing of undamaged, undistorted fingerprints from below the skins surface using optical coherence tomography hardware, the extraction and conversion of the subsurface data into a usable fingerprint and the matching of such fingerprints. The ability of ...

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    10. Study on internal to surface fingerprint correlation using optical coherence tomography and internal fingerprint extraction

      Study on internal to surface fingerprint correlation using optical coherence tomography and internal fingerprint extraction

      Surface fingerprint scanners are limited to a two-dimensional representation of the fingerprint topography, and thus, are vulnerable to fingerprint damage, distortion, and counterfeiting. Optical coherence tomography (OCT) scanners are able to image (in three dimensions) the internal structure of the fingertip skin. Techniques for obtaining the internal fingerprint from OCT scans have since been developed. This research presents an internal fingerprint extraction algorithm designed to extract high-quality internal fingerprints from touchless OCT fingertip scans. Furthermore, it serves as a correlation study between surface and internal fingerprints. Provided the scanned region contains sufficient fingerprint information, correlation to the surface topography is ...

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    11. Methods of Melanoma Detection

      Methods of Melanoma Detection

      Detection and removal of melanoma, before it has metastasized, dramatically improves prognosis and survival. The purpose of this chapter is to (1) summarize current methods of melanoma detection and (2) review state-of-the-art detection methods and technologies that have the potential to reduce melanoma mortality. Current strategies for the detection of melanoma range from population-based educational campaigns and screening to the use of algorithm-driven imaging technologies and performance of assays that identify markers of transformation. This chapter will begin by describing state-of-the-art methods for educating and increasing awareness of at-risk individuals and for performing comprehensive screening examinations. Standard and advanced photographic ...

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    12. Kim Phuc: Vietnam War burns victim treated with help from Maidstone-based Michelson Diagnostics VivoSight device

      Kim Phuc: Vietnam War burns victim treated with help from Maidstone-based Michelson Diagnostics VivoSight device

      The image of a nine-year-old Kim Phuc running naked from a napalm strike during the Vietnam War symbolised the agony and suffering caused in conflict. She thought the pain from burns inflicted in 1972 would only leave her in death but a pioneering laser treatment is giving her a new lease of life – with help from a device manufactured and developed in Kent. Last month, the 52-year-old war victim flew from her home in Canada to Miami to begin a complex series of procedures to reduce the appearance and tenderness of her scars. Doctor Jill Waibel examines Kim Phuc before ...

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    13. In vivo assessment of optical properties of melanocytic skin lesions and differentiation of melanoma from non-malignant lesions by high-definition optical coherence tomography

      In vivo assessment of optical properties of melanocytic skin lesions and differentiation of melanoma from non-malignant lesions by high-definition optical coherence tomography

      One of the most challenging problems in clinical dermatology is the early detection of melanoma. Reflectance confocal microscopy (RCM) is an added tool to dermoscopy improving considerably diagnostic accuracy. However, diagnosis strongly depends on the experience of physicians. High-definition optical coherence tomography (HD-OCT) appears to offer additional structural and cellular information on melanocytic lesions complementary to that of RCM. However, the diagnostic potential of HD-OCT seems to be not high enough for ruling out the diagnosis of melanoma if based on morphology analysis. The aim of this paper is first to quantify in vivo optical properties such as light attenuation ...

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    14. Real-time imaging of suction blistering in human skin using optical coherence tomography

      Real-time imaging of suction blistering in human skin using optical coherence tomography

      Separation of skin epidermis from the dermis by suction blistering has been used with high success rate for autologous skin epidermal grafting in burns, chronic wounds and vitiligo transplantation treatment. Although commercial products that achieve epidermal grafting by suction blistering are presently available, there is still limited knowledge and understanding on the dynamic process of epidermal-dermal separation during suction blistering. In this report we integrated a suction system to an Optical Coherence Tomography (OCT) which allowed for the first time, real-time imaging of the suction blistering process in human skin. We describe in this report the evolution of a suction ...

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    15. Treatment monitoring of 0.5% 5-fluorouracil and 10% salicylic acid in clinical and subclinical actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy

      Treatment monitoring of 0.5% 5-fluorouracil and 10% salicylic acid in clinical and subclinical actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy

      Background Reflectance confocal microscopy (RCM) and high-definition optical coherence tomography (HD-OCT) allow the observation in vivo of dynamic changes in response to non-surgical treatment of actinic keratosis and field of cancerisation. Objective To non-invasively assess the pharmacodynamic changes induced by treatment with low dose 5-fluorouracil and 10% salicylic acid by means of RCM and high-definition OCT in field cancerization and actinic keratosis. Methods Twenty patients aged >50 years with diagnosis of actinic keratosis on the head and face and indication for treatment with 0.5% 5-fluorouracil and 10% salicylic acid were enrolled. An area of 25 cm² including visible type ...

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    16. Evaluation of Optical Coherence Tomography as a Means of Identifying Earlier Stage Basal Cell Carcinomas while Reducing the Use of Diagnostic Biopsy

      Evaluation of Optical Coherence Tomography as a Means of Identifying Earlier Stage Basal Cell Carcinomas while Reducing the Use of Diagnostic Biopsy

      Objective : To determine the diagnostic accuracy of optical coherence tomography for basal cell carcinoma and the proportion of biopsies that could be avoided if optical coherence tomography is used to rule-in surgery. Design : Multicenter, prospective, observational study. Setting : Dermatology clinics. Participants : Consecutive patients with clinically challenging pink lesions suspicious for basal cell carcinoma. Measurements : Clinical, dermoscopic, and optical coherence tomography images were obtained for all subjects. At each stage, the clinician made a diagnosis (pathology + subtype if applicable), and assessed his/her own confidence in the diagnosis. Results : Optical coherence tomography significantly (p<0.01) improved sensitivity and specificity over ...

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    17. How biophysical in vivo testing techniques can be used to characterize full thickness skin equivalents

      How biophysical in vivo testing techniques can be used to characterize full thickness skin equivalents

      Background The reliability of the biophysical properties of skin equivalents (SEs) remains a challenge for medical applications and for product efficacy tests following the European Directive 2003/15/EC2 on the prohibition of animal experiments for cosmetic products. Methods We propose to adapt the biophysical in vivo testing techniques to compare full thickness model growth vs. time. The interest in using such techniques lies in possible comparisons between in vivo and in vitro skin as well as monitoring samples over the culture time. Results High frequency ultrasound technique, optical coherence tomography (OCT), and laser scanning microscopy were used to analyze ...

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    18. Michelson Diagnostics: Use of VivoSight OCT Scanner Significantly Improves Early-Stage Diagnosis of Basal Cell Carcinoma and Reduces Need for Skin Biopsies

      Michelson Diagnostics: Use of VivoSight OCT Scanner Significantly Improves Early-Stage Diagnosis of Basal Cell Carcinoma and Reduces Need for Skin Biopsies

      Michelson Diagnostics, a medical device company focused on applications of multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces data showing that use of its VivoSight OCT scanner significantly improves diagnosis of basal-cell carcinoma (BCC) at an earlier stage and reduces diagnostic biopsies by 36%. Scanning with VivoSight OCT provides clinicians with continuous images of the epidermis and superficial dermis of the skin that can be interpreted by a medical professional during the diagnostic process. The data, from a multi-centre, prospective study conducted in the US is published in the October issue of the Journal of Clinical and Aesthetic Dermatology . “The ...

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    19. Internal fingerprint sensor peers inside fingertips for more surefire ID

      Internal fingerprint sensor peers inside fingertips for more surefire ID

      In the 1971 film Diamonds are Forever, British secret agent James Bond uses fake fingerprints as part of a ploy to assume the identity of a diamond smuggler. At the time, sham prints were purely a futuristic bit of Bond gadgetry, but technology has since caught up. In 2002, the Japanese cryptographer Tsutomu Matsumoto showed that imitation fingerprints made cheaply from gelatin, a main component of gummy sweets, could trick up to 80 percent of standard fingerprint sensors. The sensors also sometimes fail to recognize legitimate prints when the finger being scanned is dirty, worn, scarred, or too wet or ...

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    20. Fingerprint imaging from the inside of a finger with full-field optical coherence tomography

      Fingerprint imaging from the inside of a finger with full-field optical coherence tomography

      Imaging below fingertip surface might be a useful alternative to the traditional fingerprint sensing since the internal finger features are more reliable than the external ones. One of the most promising subsurface imaging technique is optical coherence tomography (OCT), which, however, has to acquire 3-D data even when a single en face image is required. This makes OCT inherently slow for en face imaging and produce unnecessary large data sets. Here we demonstrate that full-field optical coherence tomography (FF-OCT) can be used to produce en face images of sweat pores and internal fingerprints, which can be used for the identification ...

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    21. Characterization of Knuckle (Garrod) Pads Using Optical Coherence Tomography In Vivo

      Characterization of Knuckle (Garrod) Pads Using Optical Coherence Tomography In Vivo

      To the Editor: Optical coherence tomography (OCT) is a noninvasive imaging technique that uses a low-power infrared laser light for cutaneous architecture visualization up to 2 mm in depth. Both malignant and nonmalignant lesions on OCT imaging have been correlated with histopathologic analysis. 1 We describe the diagnostic features of knuckle pads on OCT. A 43-year-old-man presented with warts on the right thumb and bilateral feet of several months’ duration with noncontributory medical and social history. Physical examination revealed nontender, well-demarcated, flesh-colored, verrucous papules on the dorsal interphalangeal joints of the right thumb and several toes (Figure 1). Pinpoint vessels ...

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    22. NITID (Optical Coherence Tomography and Digital Dermatoscope Handheld Device) – CE Mark Approval Received

      NITID (Optical Coherence Tomography and Digital Dermatoscope Handheld Device) – CE Mark Approval Received

      DermaLumics, a recently founded spin-off of optical tomography systems developer MedLumics, announces that NITID, its first skin diagnostic solution, received CE Mark approval in Europe. NITID employs platform technology developed by MedLumics, miniaturizing optical coherence tomography systems into a small chip through integrated optics. NITID is a breakthrough and cuttingedge diagnostic imaging solution for Dermatology that will provide doctors with exceptional results and ease of use, improving patient flow and bringing pathology analysis closer to the patient. “The creation of DermaLumics and commercial introduction of NITID are key achievements that realize the value of our technology platform and that take ...

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    1-24 of 579 1 2 3 4 ... 23 24 25 »
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