1. Articles in category: Dermatology

    1-24 of 685 1 2 3 4 ... 27 28 29 »
    1. Textural analysis of optical coherence tomography skin images: quantitative differentiation between healthy and cancerous tissues

      Textural analysis of optical coherence tomography skin images: quantitative differentiation between healthy and cancerous tissues

      Optical Coherence Tomography (OCT) offers real-time high-resolution three-dimensional images of tissue microstructures. In this study, we used OCT skin images acquired from ten volunteers, neither of whom had any skin conditions addressing the features of their anatomic location. OCT segmented images are analyzed based on their optical properties (attenuation coefficient) and textural image features e.g., contrast, correlation, homogeneity, energy, entropy, etc. Utilizing the information and referring to their clinical insight, we aim to make a comprehensive computational model for the healthy skin. The derived parameters represent the OCT microstructural morphology and might provide biological information for generating an atlas ...

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    2. Vehicle type affects filling of fractional laser-ablated channels imaged by optical coherence tomography

      Vehicle type affects filling of fractional laser-ablated channels imaged by optical coherence tomography

      Ablative fractional laser (AFXL) is an emerging method that enhances topical drug delivery. Penetrating the skin in microscopic, vertical channels, termed microscopic treatment zones (MTZs), the fractional technique circumvents the skin barrier and allows increased uptake of topically applied drugs. This study aims to elucidate the impact of vehicle type on the filling of MTZs from application of liquid, gel, and cream vehicles. Ex vivo pig skin was exposed to 10,600 nm fractional CO 2 laser at 5% density, 120 μm beam diameter, and fluences of 40 and 80 mJ/microbeam (mJ/mb). Six repetitions were performed for each ...

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    3. Multi-beam optical coherence tomography for microvascular imaging of human skin in vivo

      Multi-beam optical coherence tomography for microvascular imaging of human skin in vivo

      In this paper, a multi-beam optical coherence tomography (OCT) was used to reconstruct the microvascular image of human skin in vivo with phase resolved Doppler OCT (PRDOCT), phase resolved Doppler variance (PRDV) and speckle variance OCT (svOCT), in which the blood flow image was calculated by averaging the four blood flow images obtained by the four beams. In PRDOCT method, it is difficult to detect the blood flow perpendicular to optical axis of the probe beam for single beam OCT, but the multi-beam scanning method can solve this because the input angles of the four probe beams are slightly different ...

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    4. Birefringence and vascular imaging of in vivo human skin by Jones-matrix optical coherence tomography

      Birefringence and vascular imaging of in vivo human skin by Jones-matrix optical coherence tomography

      A customized 1310-nm Jones-matrix optical coherence tomography (JM-OCT) for dermatological investigation was constructed and used for in vivo normal human skin tissue imaging. This system can simultaneously measure the threedimensional depth-resolved local birefringence, complex-correlation based OCT angiography (OCT-A), degree-ofpolarization- uniformity (DOPU) and scattering OCT intensity. By obtaining these optical properties of tissue, the morphology, vasculature, and collagen content of skin can be deduced and visualized. Structures in the deep layers of the epithelium were observed with depth-resolved local birefringence and polarization uniformity images. These results suggest high diagnostic and investigative potential of JM-OCT for dermatology.

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    5. Non-invasive skin imaging for the diagnosis of myiasis

      Non-invasive skin imaging for the diagnosis of myiasis

      A 52-year-old man presented with a painful ulceration of the scalp (Fig. 1a). He had returned from Guyana the previous week. Dermoscopic examination (FotoFinder Systems GmbH, Bad Birnbach, Germany) showed an intermittent dynamic aspect changing from a sanguineous roundish ulcer (Fig. 1b) to a peculiar roundish structure characterized by a yellowish peripheral ring and a central brownish part (Fig. 1c). High-definition optical coherence tomography (HD-OCT; Skintell ® ; Agfa Gevaert, Antverpen, Belgium) showed a skin cavity (Fig. 2a). Reflectance confocal microscopy (RCM; Vivascope 3000 ® , Caliber, New York, USA, distributed in Europe by MAVIG GmbH, München, Germany) showed the roundish structure observed ...

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      Mentions: AGFA Healthcare
    6. Optical coherence tomography imaging of bullous diseases

      Optical coherence tomography imaging of bullous diseases

      Background  Optical coherence tomography (OCT) is a non-invasive optical imaging technique with a micrometer resolution that may potentially offer real-time bedside imaging of sufficient detail to allow for morphological discrimination between different types of bullae. Objective  To explore the potential of OCT in bullous skin disorders by looking at a set of patients with skin blisters of known origin and study the OCT images for possible hallmarks of the blistering level. Materials and methods  OCT provides cross-sectional, tomographic images of the skin. A consecutive series of patients were recruited and their lesions imaged by OCT: 3 patients with bullous pemphigoid ...

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    7. Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography

      Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography

      Background and Aim: With inflammatory skin conditions such as atopic dermatitis (AD), epidermal thickness is mediated by both pathological hyperplasia and atrophy such as that resulting from corticosteroid treatment. Such changes are likely to influence the depth and shape of the underlying microcirculation. Optical coherence tomography (OCT) provides a non-invasive view into the tissue, however structural measures of epidermal thickness are made challenging due to the lack of a delineated dermal-epidermal junction in AD patients. Instead, angiographic extensions to OCT may allow for direct measurement of vascular depth, potentially presenting a more robust method of estimating the degree of epidermal ...

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    8. Optical coherence tomography for image-guided dermal filler injection and biomechanical evaluation

      Optical coherence tomography for image-guided dermal filler injection and biomechanical evaluation

      Dermal fillers are a very popular anti-aging treatment with estimated sales in the billions of dollars and millions of procedures performed. As the aging population continues to grow, these figures are only expected to increase. Dermal fillers have various compositions depending on their intended application. Reactions to dermal fillers can be severe, such as ischemic events and filler migration to the eyes. However, these adverse reactions are rare. Nevertheless, the capability to perform image-guided filler injections would minimize the risk of such reactions. In addition, the biomechanical properties of various fillers have been evaluated, but there has been no investigation ...

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    9. Optical coherence tomography in the diagnosis of actinic keratosis – A systematic review

      Optical coherence tomography in the diagnosis of actinic keratosis – A systematic review

      Background Optical coherence tomography (OCT) is a real-time non-invasive imaging tool, introduced in dermatology in the late 1990s. OCT uses near-infrared light impulses to produce images which can be displayed in cross-sectional and en-face mode. The technique has been used to image skin diseases especially non-melanoma skin cancer including actinic keratosis (AK). Morphological characteristics of AK can be visualized in OCT images and can be used for diagnosis as well as disease monitoring. Methods A systematic review of original papers on AK and OCT was performed on 31.03.16 and 24.10.16 in the major databases Pubmed, MEDLINE ...

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    10. An integrated skin marking tool for use with optical coherence tomography (OCT)

      An integrated skin marking tool for use with optical coherence tomography (OCT)

      Optical coherence tomography (OCT) has been shown to provide clinically valuable images that can aid in the assessment of the pre-surgical margin in basal cell carcinoma (BCC). The accuracy and speed with which these images can be used to help delineate margins in the clinic are currently constrained by the need to suspend imaging whilst a pen is used to mark the skin. This constraint has been circumvented here by the design of a trigger-activated ink-loaded nib integrated with the OCT probe. The adapted OCT probe enables a mark to be placed on the skin precisely where a region of ...

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    11. Three-dimensional multi-contrast imaging of in vivo human skin by Jones matrix optical coherence tomography

      Three-dimensional multi-contrast imaging of in vivo human skin by Jones matrix optical coherence tomography

      A custom made dermatological Jones matrix optical coherence tomography (JM-OCT) is presented. It uses a passive-polarization-delay component based swept-source JM-OCT configuration, but is specially designed for in vivo human skin measurement. The center wavelength of its probe beam is 1310 nm and the A-line rate is 49.6 kHz. The JM-OCT is capable of simultaneously providing birefringence (local retardation) tomography, degree-of-polarization-uniformity tomography, complex-correlation-based optical coherence angiography, and conventional scattering OCT. To evaluate the performance of this JM-OCT, we measured in vivo human skin at several locations. Using the four kinds of OCT contrasts, the morphological characteristics and optical properties of ...

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    12. Dermoscopy guided dark-field multi-functional optical coherence tomography

      Dermoscopy guided dark-field multi-functional optical coherence tomography

      Dermoscopy is a skin surface microscopic technique allowing specular reflection free observation of the skin, and has been used to examine pigmented skin lesions. However, dermoscopy has limitations in providing depth information due to lack of 3D resolution. In order to overcome the limitations, we developed dermoscopy guided multi-functional optical coherence tomography (MF-OCT) providing both high-contrast superficial information and depth-resolved structural, birefringent, and vascular information of the skin simultaneously. Dermoscopy and MF-OCT were combined by using a dichroic mirror, and dark-field configuration was adapted for MF-OCT to reduce specular reflection. After characterization, dermoscopy guided MF-OCT was applied to several human ...

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    13. Optical Coherence Tomography Imaging of Basal Cell Carcinoma Undergoing Photodynamic Therapy: A Pilot Study

      Optical Coherence Tomography Imaging of Basal Cell Carcinoma Undergoing Photodynamic Therapy: A Pilot Study

      The conversion of hyporeflective basal cell carcinoma nodules into hyperreflective ovoid structures was remarked with optical coherence tomography (OCT) as a sign of tumor regression under photodynamic therapy (PDT). OCT presented a higher accuracy in identifying residual and non-residual lesions after PDT treatment compared to clinical inspection alone.  OCT might be used in the future as a standard procedure for detecting non-melanoma skin cancer sparing patients invasive procedures.

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    14. Optical coherence tomography as a method for quantitative skin evaluation in systemic sclerosis

      Optical coherence tomography as a method for quantitative skin evaluation in systemic sclerosis

      Improved, non-invasive techniques for the diagnosis, classification and monitoring of patients with systemic sclerosis (SSc) are needed. One potential technique for quantifying the extent of cutaneous sclerosis in these patients is optical coherence tomography (OCT). 1 , 2 Recently, Abignano et al 3 suggested the use of OCT as a feasible and reliable technique to evaluate skin fibrosis in SSc. Based on that initial work, the aim of this study was to evaluate OCT images and compare the findings with the modified Rodnan skin score (mRSS) in patients with SSc. Thirty-three Brazilian patients with SSc (28 women; mean age 46.1 ...

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    15. Use of optical coherence tomography for the diagnosis of preclinical lesions of circumscribed palmar hypokeratosis

      Use of optical coherence tomography for the diagnosis of preclinical lesions of circumscribed palmar hypokeratosis

      Circumscribed hypokeratosis of palms and soles is a rare dermatosis, usually affecting women. Diagnosis is mainly based on the clinical characteristics, including the clinical appearance and anatomical site of the skin lesions and on the demographic features of the affected patients, usually middle-aged to elderly women. Skin biopsy may be performed to confirm clinical diagnosis. Optical coherence tomography (OCT) is a technique that has been undergone substantial development in dermatology in recent years, and its use in clinical practice has been growing progressively. Several dermatological conditions have been studied with this tool, but to our knowledge, it has not been ...

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    16. Application to skin physiology using optical coherence tomography

      Application to skin physiology using optical coherence tomography

      Background and aims: The sweat glands and peripheral vessels beneath the skin surface act as minute organs governed by the skin sympathetic nerves and have important physiological functions for body temperature control and nutrition support along with maintenance of a peripheral organization. Dynamics of the mental sweating of sweat glands and the peripheral vessels reflect the activity of a sympathetic nerve. The purpose of this paper is to study the dynamic observation and analysis of sweat glands and a peripheral vessels by optical coherence tomography (OCT). Materials and Methods: In the dynamic analysis of mental sweating of sweat glands, after ...

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      Mentions: Osaka University
    17. Comparative study of presurgical skin infiltration depth measurements of melanocytic lesions with OCT and high frequency ultrasound

      Comparative study of presurgical skin infiltration depth measurements of melanocytic lesions with OCT and high frequency ultrasound

      A reliable, fast, and non-invasive determination of melanoma thickness in vivo is highly desirable for clinical dermatology as it may facilitate the identification of surgical melanoma margins, determine if a sentinel node biopsy should be performed or not, and reduce the number of surgical interventions for patients. In this work, optical coherence tomography (OCT) and high frequency ultrasound (HFUS) are evaluated for quantitative in vivo preoperative assessment of the skin infiltration depth of melanocytic tissue. Both methods allow non-invasive imaging of skin at similar axial resolution. Comparison with the Breslow lesion thickness obtained from histopathology revealed that OCT is slightly ...

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    18. A useful way to develop effective in vivo skin optical clearing agents

      A useful way to develop effective in vivo skin optical clearing agents

      Skin optical clearing has shown tremendous potential in improving various optical imaging performances, but there is some certain blindness in screening out high-efficiency in vivo optical clearing methods. In this work, three optical clearing agents: sucrose (Suc), fructose (Fruc) and PEG-400 (PEG), and two chemical penetration enhancers: propylene glycol (PG) and thiazone (Thiaz) were used. PEG was firstly mixed with the two penetration enhancers, respectively, and then mixed with Fruc and Suc, respectively, to obtain six kinds of skin optical clearing agents (SOCAs). Optical coherence tomography angiography was applied to monitor SOCAs-induced changes in imaging performances, skin optical properties, refractive ...

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    19. A Correlation Study between Two Adjacent Same-Meridian Acupoints after Laser-Needle Acupuncture with Optical Coherence Tomography and Diffuse Reflectance Spectra

      A Correlation Study between Two Adjacent Same-Meridian Acupoints after Laser-Needle Acupuncture with Optical Coherence Tomography and Diffuse Reflectance Spectra

      This study is to investigate the correlations among Sanjian (LI3), Hegu (LI4), and Yangxi (LI5) acupoints and their corresponding nonacupoints on the Yangming Large Intestine Meridian of Hand before and after laser irradiation using optical coherence tomography (OCT) and diffuse reflectance spectra. The experiment was conducted on 10 healthy people. A 658 nm laser with 50 mW output power was used for irradiating LI4, LI5 acupoints and their corresponding nonacupoints. As to LI4 acupoint with laser irradiation for duration of 15 or 45 minutes, the OCT backscattered light intensities of LI4 and LI5 acupoints increased significantly, and the reflectance intensities ...

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    20. Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography

      Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography

      The nail provides a functional protection to the fingertips and surrounding tissue from external injuries. The nail plate consists of three layers including dorsal, intermediate, and ventral layers. The dorsal layer consists of compact, hard keratins, limiting topical drug delivery through the nail. In this study, we investigate the application of fractional CO 2 laser that produces arrays of microthermal ablation zones (MAZs) to facilitate drug delivery in the nails. We utilized optical coherence tomography (OCT) for real-time monitoring of the laser–skin tissue interaction, sparing the patient from an invasive surgical sampling procedure. The time-dependent OCT intensity variance was ...

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    1-24 of 685 1 2 3 4 ... 27 28 29 »
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