Popular Articles
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OCT Products in the News
(5 articles) Michelson Diagnostics Vivosight
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(14 articles) University of Copenhagen
(10 articles) University of Manchester
(9 articles) Technical University of Denmark
(3 articles) Moscow State University
(3 articles) Saratov State University
(3 articles) Russian Academy of Sciences
(3 articles) Nizhny Novgorod State Medical Academy
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Imaging of subcutaneous blood vessels and flow velocity profiles by optical coherence tomography
Explore Article SpringerLink Home (Mar 11 2010) Dermatology , Doppler
We have applied a compact low power rapid scanning Doppler Optical Coherence Tomography system to monitor multi-dimensional velocity profiles within the complex vessels and simultaneous real-time non-invasive imaging of skin tissues morphology in vivo, in the wavelength range of 1.3–1.5 nm. Optical clearing of skin tissues has been utilized to achieve depth of OCT images up to 1.7 mm. Current approach enables applying low-power (0.4–0.5 mW) and low-noise broadband near-infrared light sources and obtaining OCT images with down to 12 μm spatial resolution. Two-dimensional time-domain OCT images of complex flow velocity profiles in blood vessel phantom and in vivo subcutaneous ...
Comment on Article Mentions: Medical University of Vienna University of Otago Igor V. Meglinski
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A new device for assessing changes in skin viscoelasticity using indentation and optical measurement
Explore Article www3.interscience.wiley.com (Mar 10 2010) Dermatology
Skin is a viscoelastic material, comprised of fluidic and fibrous components. Changes in viscoelasticity can arise due to a number of conditions including dehydration, swelling (associated with injury or disease), impaired heart function, rehydration therapy, ageing, scarring, sun exposure and genetic conditions affecting connective tissue. Quantification of changes in skin viscoelasticity due to these processes is of great clinical interest in the fields of therapy monitoring, wound healing and disease screening. However, devices currently available to measure aspects of the mechanical properties of skin have limitations in ease-of-use, accessibility, and depth of measurement. This paper describes a new technique to ...
Comment on Article Mentions: Imperial College London University of Limerick
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A clinical probe for combined Raman spectroscopy/optical coherence tomography (RS-OCT) of the skin cancers
Explore Article SPIE Digital Library (Mar 2 2010) Dermatology , Oncology
Skin cancer is the most commonly occurring cancer, with incidence rates rising annually. Realizing favorable outcomes requires early diagnosis, for which the current standard is biopsy followed by histopathology. This process can be invasive, subjective, time consuming, and costly. Optical techniques, including Optical Coherence Tomography (OCT) and Raman Spectroscopy (RS), have been developed to perform non-invasive characterization of skin lesions, however neither is without limitation. Here, we demonstrate a clinical instrument for morphological and biochemical characterization of skin cancers with combined RS-OCT. The portable instrument utilizes independent RS and OCT system backbones, and is integrated in a common clinical probe. ...
Comment on Article Mentions: Anita Mahadevan-Jansen Ton G. van Leeuwen Academic Medical Center at the University of Amsterdam
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Automated measurement of epidermal thickness from optical coherence tomography images using line region growing
Explore Article SPIE Digital Library (Mar 2 2010) Dermatology
Optical Coherence Tomography (OCT) is a non-invasive imaging modality that acquires cross sectional images of tissue in-vivo. It accelerates skin diagnosis by eliminating invasive biopsy and laborious histology in the process. Dermatologists have widely used it for looking at morphology of skin diseases such as psoriasis, dermatitis, basal cell carcinoma etc. Skin scientists have also successfully used it for looking at differences in epidermal thickness and its underlying structure with respect to age, body sites, ethnicity, gender, and other related factors. Similar to other in-vivo imaging systems, OCT images suffer from a high degree of speckle and noise content, which ...
Comment on Article Mentions: Thorlabs
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Combined optical coherence tomography based on the extended Huygens-Fresnel principle and histology of mouse skin
Explore Article SPIE Digital Library (Feb 25 2010) Dermatology
Noninvasive measurement technique to obtain tissue optical properties such as the scattering coefficient µs and the anisotropy factor g using optical coherence tomography (OCT) scattering model which based on the Extended Huygens-Fresnel principle is developed in our paper. Older and younger mouse-skin are as animal model to compare its scattering coefficient µs and the anisotropy factor g, the outcome shows that scattering coefficient µs is increased with the age of mouse-skin. Furthermore, we have made age's mouse-skin into H.E stain slices; the result of its morphology is consistent with the OCT imaging and OCT-EHF principle. All of that have provided ...
Comment on Article Mentions: Photop Technologies
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Using swept source optical coherence tomography to monitor wound healing in tissue engineered skin
Explore Article SPIE Digital Library (Feb 24 2010) Dermatology
There is an increasing need for a robust simple to use non-invasive imaging technology for monitoring tissue engineered constructs as they develop. We have applied optical coherence tomography (OCT), a relatively new optical technique, to image tissue engineered constructs. Our aim was to evaluate the use of swept-source optical coherence tomography (SSOCT) to non-invasively image reconstructed skin as it developed over several weeks. The epidermis of the reconstructed skin was readily distinguished from the neodermis when examined with standard histology - a destructive imaging technique - of samples. The development of reconstructed skin based on deepithelialised acellular dermis (DED) was ...
Comment on Article Mentions: Steven J. Matcher University of Sheffield Medical University of Vienna
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Optical coherence tomography investigation of growth cycles of engineered skin tissue
Explore Article SPIE Digital Library (Feb 24 2010) Dermatology
Engineered skin tissues are widely used in dermatological, pharmacological and toxicological studies and as autologous transplants in wound healing. Due to the high demand for artificial skin equivalents, there is a need for an automation of the manual production process to achieve a high-grade product. Thus, non-invasive monitoring of engineered tissue during the growth cycles is of major significance to understand and consequently improve the growth characteristics of in vitro tissue. Prior to the framework of the automation of artificial humanoid 3d-skin tissue engineering, optimal growth parameters need to be determined. The successful engineering of humanoid tissue is strongly coupled ...
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A gel-based skin and blood flow model for a Doppler optical coherence tomography (DOCT) imaging system
Explore Article SPIE Digital Library (Feb 23 2010) Dermatology , Doppler
Since its discovery in 1842 by Christian Johann Doppler, the Doppler Effect has had many applications in the scientific world. In recent years, the phenomenon has been integrated with Optical Coherence Tomography (OCT) yielding Doppler Optical Coherence Tomography (DOCT), a technique that is useful for high-resolution imaging of the skin microcirculation. However, interpretation of DOCT images is rather challenging. Thus, our study aims to aid understanding of DOCT images with respect to parameters of microcirculation components such as blood vessel size, depth and angular position. To this end, we have constructed a gel-based tissue and blood-flow model for performing DOCT ...
Comment on Article Mentions: University of Limerick
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Synergistic Effect of Ultrasound and Thiazone–PEG 400 on Human Skin Optical Clearing In Vivo
Explore Article www3.interscience.wiley.com (Feb 22 2010) Dermatology
In this paper, we propose a new physical method in combination with mixed solution of thiazone and polyethylene glycol 400 (thiazone PEG 400 solution) penetration into tissue to assess the skin optical clearing. Four treatments were performed: (1) control group (C); (2) polyethylene glycol 400 (PEG400); (3) 0.25% thiazone (0.25%T); (4) 0.25% thiazone and 5-min ultrasound (0.25%T/SP). The diffuse reflectance spectra and imaging depth of human skin in vivo at different times were measured by spectroscopy and optical coherence tomography (OCT). The optical clearing efficacy of skin was qualitatively and quantitatively analyzed. The results showed that the diffuse reflectance at ...
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Clinical optical coherence tomography combined with multiphoton tomography for evaluation of several skin disorders
Explore Article SPIE Digital Library (Feb 19 2010) Dermatology , Oncology
The first clinical trial of optical coherence tomography (OCT) combined with multiphoton tomography (MPT) and dermoscopy is reported. State-of-the-art (i) OCT systems for dermatology (e.g. multibeam swept source OCT), (ii) the femtosecond laser multiphoton tomograph DermaInspectTM, and (iii) digital dermoscopes were applied to 47 patients with a diversity of skin diseases and disorders such as skin cancer, psoriasis, hemangioma, connective tissue diseases, pigmented lesions, and autoimmune bullous skin diseases. Dermoscopy, also called 'epiluminescent microscopy', provides two-dimensional color images of the skin surface. OCT imaging is based on the detection of optical reflections within the tissue measured interferometrically whereas nonlinear excitation ...
Comment on Article Mentions: Michelson Diagnostics Gordon Mckenzie
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Characterizing matrix remodeling in collagen gels using optical coherence tomography
Explore Article SPIE Digital Library (Feb 19 2010) Dermatology
Optical coherence tomography (OCT) has shown promise at non-destructively characterizing engineered tissues such as collagen gels. However, as the collagen gels develop, the OCT images lose contrast of structures as the gels develop, making visual assessment difficult. Our group proposed quantitatively characterizing these gels by fitting the optical properties from the OCT signals. In this paper, we imaged collagen gels seeded with smooth muscle cells (SMCs) over a 5-day period and used the data to measure their optical properties. Our results showed that over time, the reflectivity of the samples increased 10-fold, corresponding to a decrease in anisotropy factor g, ...
Comment on Article Mentions: David Levitz Steven L. Jacques Oregon Health & Science University
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In vivo optical coherence tomography of percutaneous implants in hairless mice
Explore Article SPIE Digital Library (Feb 19 2010) Dermatology
Biocompatibility studies of percutanous implants in animal models usually involve numerous lethal biopsies for subsequent morphometric analysis of the implant-tissue interface. A common drawback of the study protocol is the restriction of the analysis to one final time point. In this study optical coherence tomography (OCT) was used to visualize and enable quantification of the local skin anatomy in the vicinity of a percutaneous implant in an animal model using hairless mice. Non invasive in vivo optical biopsies were taken on predetermined time points after implantation and ex vivo in situ at the day of noticeable inflammation. The custom made ...
Comment on Article Mentions: Laser Zentrum Hannover University of Pittsburgh Ole Massow
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Gabor-based fusion technique for Optical Coherence Microscopy
Explore Article opticsinfobase.org (Feb 4 2010) Dermatology , Developmental Biology , Microscopy
We recently reported on an Optical Coherence Microscopy technique, whose innovation intrinsically builds on a recently reported - 2 μm invariant lateral resolution by design throughout a 2 mm cubic full-field of view - liquid-lens-based dynamic focusing optical probe [Murali et al.,Optics Letters 34, 145-147, 2009]. We shall report in this paper on the image acquisition enabled by this optical probe when combined with an automatic data fusion method developed and described here to produce an in-focus high resolution image throughout the imaging depth of the sample. An African frog tadpole (Xenopus laevis) was imaged with the novel probe and ...
Comment on Article Mentions: University of Rochester University of Central Florida Jannick P. Rolland
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Full-Field Optical Coherence Tomography for the Rapid Estimation of Epidermal Thickness
Explore Article Optical Coherence Tomography News (Jan 16 2010) Dermatology , Glucose
Feature Of The Week 1/17/10: A number of recent developments in non-invasive physiological monitoring of the human body have demonstrated a high potential for the use of such techniques in the in vivo estimation of various clinically relevant parameters such as haemoglobin content and its’ oxygen
Comment on Article Mentions: Heliotis AG Andreas Caduff Isabel Kolm
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Generalized Jones matrix optical coherence tomography: performance and local birefringence imaging
Explore Article opticsinfobase.org (Jan 6 2010) Dermatology , Ophthalmology
Phase retardation imaging including local birefringence imaging of biological tissues is described by generalized Jones-matrix optical coherence tomography. The polarization properties of a local tissue can be obtained from two Jones matrices that are measured by backscattered lights from the front and back boundaries of the local tissue. The error in the phase retardation measurement due to background noise is analyzed theoretically, numerically, and experimentally. The minimum detectable phase retardation is estimated from numerical simulations. The theoretical analysis suggests that the measurements with two orthogonal input polarization states have the lowest retardation error. Local birefringence imaging is applied to the ...
Comment on Article Mentions: Shuichi Makita Yoshiaki Yasuno Masahiro Yamanari
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