1. Articles in category: Dermatology

    1-24 of 423 1 2 3 4 ... 16 17 18 »

    1. High resolution in-vivo imaging of skin with full field optical coherence tomography

      Explore Conference Proceedings Dermatology
      High resolution in-vivo imaging of skin with full field optical coherence tomography

      Full-field OCT (FFOCT) has the ability to provide en-face images with a very good axial sectioning as well as a very high transverse resolution (about 1 microns in all directions). Therefore it offers the possibility to visualize biological tissues with very high resolution both on the axial native view, and on vertical reconstructed sections. Here we investigated the potential dermatological applications of in-vivo skin imaging with FFOCT. A commercial FFOCT device was adapted for the in-vivo acquisition of stacks of images on the arm, hand and finger. Several subjects of different benign and pathological skin conditions were tested. The images ...

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      Mentions: Claude Boccara Fabrice Harms LLTech

    2. Michelson Diagnostics announces completion of data collection in Vivosight OCT trial for BCC diagnosis

      Explore Optical Coherence Tomography News Dermatology , Other Business News
      Michelson Diagnostics announces completion of data collection in Vivosight OCT trial for BCC diagnosis

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces that it has completed scanning and data collection for a large 250-patient, multi-centre, prospective clinical trial of the diagnostic performance of its VivoSight™ OCT scanner in diagnosing superficial basal cell carcinoma (BCC), the most common form of skin cancer. Preliminary results from the trial are to be announced at the American Academy of Dermatology (AAD) Annual meeting in Denver, in March 2014. It is expected that full results will be published in a leading peer-reviewed journal later in the year. The study ...

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      Mentions: Michelson Diagnostics Jon Holmes Gordon Mckenzie

    3. Dermascope assisted interactive patient interface for multiple reference optical coherence tomography

      Explore Conference Proceedings Dermatology
      Dermascope assisted interactive patient interface for multiple reference optical coherence tomography

      There has been a growing interest in the development of a low cost depth-resolved non-invasive dermis imaging tool for both clinical and fundamental investigations of skin diseases. Multiple reference optical coherence tomography (MR-OCT) is a recently developed miniature time-domain low coherence interferometeric imaging platform, which promises to fit into robust, cost-effective designs that are virtually solid state, typical of handheld devices. In this paper we demonstrate the feasibility of MR-OCT for dermis imaging applications by incorporating it in a dermascope, which provides simultaneous imaging of dermis and an interactive tool for beam steering and registration of the OCT imaging beam ...

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      Mentions: Hrebesh M. Subhash Martin J. Leahy National University of Ireland, Galway

    4. Motion tracking to enable pre-surgical margin mapping in basal cell carcinoma using optical imaging modalities: initial feasibility study using optical coherence tomography

      Explore Conference Proceedings Dermatology
      Motion tracking to enable pre-surgical margin mapping in basal cell carcinoma using optical imaging modalities: initial feasibility study using optical coherence tomography

      A system has been developed to assess the feasibility of using motion tracking to enable pre-surgical margin mapping of basal cell carcinoma (BCC) in the clinic using optical coherence tomography (OCT). This system consists of a commercial OCT imaging system (the VivoSight 1500, MDL Ltd., Orpington, UK), which has been adapted to incorporate a webcam and a single-sensor electromagnetic positional tracking module (the Flock of Birds, Ascension Technology Corp, Vermont, USA). A supporting software interface has also been developed which allows positional data to be captured and projected onto a 2D dermoscopic image in real-time. Initial results using a stationary ...

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      Mentions: Michelson Diagnostics Michelson Diagnostics Vivosight Kings College London

    5. Continuous noninvasive monitoring of changes in human skin optical properties during oral intake of different sugars with optical coherence tomography

      Explore opticsinfobase.org Dermatology
      Continuous noninvasive monitoring of changes in human skin optical properties during oral intake of different sugars with optical coherence tomography

      The objective of this study was to evaluate the effects of blood glucose concentration (BGC) on in vivo human skin optical properties after oral intake of different sugars. In vivo optical properties of human skin were measured with a spectral domain optical coherence tomography (SD-OCT). Experimental results show that increase of BGC causes a decrease in the skin attenuation coefficient. And the maximum decrements in mean attenuation coefficient of skin tissue after drinking glucose, sucrose and fructose solution are 47.0%, 36.4% and 16.5% compared with that after drinking water, respectively (p < 0.05). The results also show ...

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      Mentions: Sun Yat-Sen University Tsinghua University Fujian Normal University

    6. High-definition optical coherence tomography and reflectance confocal microscopy in the in vivo visualization of a reaction to permanent make-up

      Explore Wiley Online Library Dermatology
      High-definition optical coherence tomography and reflectance confocal microscopy in the in vivo visualization of a reaction to permanent make-up

      Background and Objectives After permanent make-up treatments, eczematous and granulomatous reactions may occur which need anti-inflammatory treatment. For the definite diagnosis oftentimes biopsies are recommended. In vivo imaging such as reflectance confocal microscopy (RCM) and high-definition optical coherence tomography (HD-OCT) has been successfully used in the non-invasive diagnosis of various dermatoses before. Methods Here, we report on non-invasive imaging of a reaction towards permanent make-up in a 40-year-old woman by using HD-OCT and RCM. Results Both in HD-OCT and in RCM subepidermal pigment and granulomatous changes could be visualized and correlated with the histopathological findings. Regression of the lesions in ...

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      Mentions: AGFA Healthcare

    7. Correlation of optical coherence tomography and histology in microcystic adnexal carcinoma: a case report

      Explore Wiley Online Library Dermatology
      Correlation of optical coherence tomography and histology in microcystic adnexal carcinoma: a case report

      Background/Aims Herein, we report a case of microcystic adnexal carcinoma (MAC), which we correlated and evaluated by optical coherence tomography (OCT) and conventional H&E histology. Methods A commercially available OCT scanner was used for imaging. Several multi-slice images were obtained from the central portion of the lesion. Correlation of OCT findings with histology was performed retrospectively. Results Microcystic adnexal carcinoma showed characteristic criteria, which were divided into superficial and sub-epidermal findings. Conclusion The use of OCT can visualize characteristic criteria of MAC, thus enabling prompt diagnosis before surgery.

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      Mentions: Joachim W. Fluhr Jürgen Lademann

    8. Michelson Diagnostics to launch enhanced software for VivoSight OCT scanner

      Explore Optical Coherence Tomography News Dermatology , Other Business News
      Michelson Diagnostics to launch enhanced software for VivoSight OCT scanner

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces the launch of its upgraded VivoSight OCT scanner with a new software technology that provides additional features for dermatologists to investigate skin lesions such as non-melanoma skin cancer. The VivoSight OCT scanner enables the dermatologist to see vertical cross-sectional images of sub-surface skin tissue to depths of 1-1.5 mm in high definition, providing the clinician with important information about the type, depth and lateral spread of the skin lesion that is not possible to determine from its surface visual appearance. Our ...

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      Mentions: Michelson Diagnostics Jon Holmes Michelson Diagnostics Vivosight

    9. In vivo enhancement of imaging depth for optical coherence tomography by eudermic agents on ridgedand meshed human skin

      Explore IOPscience Dermatology
      In vivo enhancement of imaging depth for optical coherence tomography by eudermic agents on ridgedand meshed human skin

      Non-invasive skin analysis by optical coherence tomography (OCT) is limited because of the absorption and scattering properties of the tissue. There are several possibilities for enhancing OCT images. The purpose of this study was to demonstrate that image quality can be improved using the hyperosmolar agents glucose and glycerol while investigating human ridged and meshed skin areas, without causing damage to the tissue. The experiments were carried out on the palm and the forearm of ten volunteers. After application of the substances in the test area, the penetration depth and image contrast were measured at intervals of 5 min for ...

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      Mentions: Joachim W. Fluhr Jürgen Lademann

    10. Michelson Diagnostics targets malignant melanoma using OCT imaging with €2.3M EU funding

      Explore Optical Coherence Tomography News Dermatology , Funding
      Michelson Diagnostics targets malignant melanoma using OCT imaging with €2.3M EU funding

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, announces that the European Union has awarded a €2.26 million Framework 7 grant to a consortium of seven partners, towards the cost of a project targeting malignant melanoma with OCT imaging. Using Michelson Diagnostics’ OCT imaging system, VivoSight, the project, named 'ADVANCE' (Automatic Detection of VAscular Networks for Cancer Evaluation), aims to demonstrate that multi-beam OCT imaging can be used to assess the aggressiveness of melanomas quickly and efficiently. Michelson Diagnostics is the lead partner in the ADVANCE project. Melanoma is the most ...

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      Mentions: Michelson Diagnostics Jon Holmes University of Copenhagen

    11. Nano-sensitive optical coherence tomography

      Explore RSC Publishing Home Dermatology
      Nano-sensitive optical coherence tomography

      Depth resolved label-free detection of structural changes with nanoscale sensitivity is an outstanding problem in the biological and physical sciences and has significant applications in both the fundamental research and healthcare diagnostics arenas. Here we experimentally demonstrate a novel label-free depth resolved sensing technique based on optical coherence tomography (OCT) to detect structural changes at the nanoscale. Structural components of the 3D object, spectrally encoded in the remitted light, are transformed from the Fourier domain into each voxel of the 3D OCT image without compromising sensitivity. Spatial distribution of the nanoscale structural changes in the depth direction is visualized in ...

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      Mentions: Hrebesh M. Subhash Martin J. Leahy National University of Ireland, Galway

    12. In vivo, high-resolution, three-dimensional imaging of port wine stain microvasculature in human skin

      Explore bli.uci.edu Dermatology
      In vivo, high-resolution, three-dimensional imaging of port wine stain microvasculature in human skin

      Port-wine stain (PWS) is a congenital, progressive vascular malformation of the dermis. In the past few years, advances in optical coherence tomography (OCT) technology have greatly increased imaging speed. Sophisticated numerical algorithms have improved the sensitivity of Doppler OCT dramatically. These improvements have enabled the noninvasive, high-resolution, three-dimensional functional imaging of PWS skin. In this study, high-resolution, three-dimensional, microvasculature imaging of PWS using Doppler OCT technique is demonstrated. Three-dimensional imaging of the subsurface vessel network of the dermis can provide information for accurate PWS classification and guidance for effective laser treatment. Invasive methods such as histology following biopsy and confocal ...

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      Mentions: J. Stuart Nelson Zhongping Chen UC Irvine

    13. MedLumics Expands Management Team in Preparation for 2014 Launch of First Generation Diagnostic Imaging System for Dermatology

      Explore Optical Coherence Tomography News Dermatology , Other Business News
      MedLumics Expands Management Team in Preparation for 2014 Launch of First Generation Diagnostic Imaging System for Dermatology

      MedLumics, a medical imaging company specializing in advanced optical coherence tomography (OCT) technology , has announced the appointment of Miguel Eslava to the new position of vice president and chief operating officer. With more than a decade of senior management experience at GE Healthcare, Mr. Eslava brings significant business operations expertise to the company in advance of the anticipated launch of the first point-of-care diagnostic imaging system for dermatology in the second half of 2014. “We expect Miguel to play a critical role at MedLumics as we move from a research and development stage company to a commercial organization” “We expect ...

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      Mentions: GE Healthcare Eduardo Margallo Balbás MedLumics

    14. Imaging of Mohs Micrographic Surgery Sections Using Full-Field Optical Coherence Tomography: A Pilot Study

      Explore Wiley Online Library Dermatology
      Imaging of Mohs Micrographic Surgery Sections Using Full-Field Optical Coherence Tomography: A Pilot Study

      Background Full-field optical coherence tomography (FF-OCT) is a new noninvasive imaging technique that can see down to the cellular level without tissue preparation or contrast agents. Objective To use FF-OCT to image Mohs micrographic surgery specimens and verify the ability of a dermatopathologist to identify or exclude malignancy. Materials and Methods Two Mohs surgeons supplied 18 Mohs sections from 11 patients. Each section was scanned using the FF-OCT, and a dermatopathologist blinded to the diagnosis examined the images for malignancy. The FF-OCT images were then compared with the intraoperative hematoxylin and eosin (H&E)-stained frozen sections for concordance. Results ...

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      Mentions: University of Pittsburgh

    15. Michelson Diagnostics Announces £1.98 Million Financing

      Explore Optical Coherence Tomography News Dermatology , Funding
      Michelson Diagnostics Announces £1.98 Million Financing

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography ('OCT') technology, is delighted to announce the first closing of its Series A2 Financing. The round, which was oversubscribed, raised £1.98 million ( $3.25million ) from existing investors, led by Octopus Investments and supported by Catapult Venture Managers Ltd and London Business Angels, and several business angels. The funds will be used for several purposes including expanding VivoSight TM sales in Germany , where the system was launched in mid-2011 and where it is reimbursed for use in the diagnosis of non-melanoma skin cancer (NMSC), the commonest ...

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      Mentions: Michelson Diagnostics Jon Holmes FDA

    16. Histopathological correlates of basal cell carcinoma in slice and en-face imaging modes of high-definition optical coherence tomography

      Explore Wiley Online Library Dermatology
      Histopathological correlates of basal cell carcinoma in slice and en-face imaging modes of high-definition optical coherence tomography

      Background High-definition optical coherence tomography (HD-OCT) scanners have recently been developed providing significantly higher resolution than conventional OCT . Objectives To assess the relationship between recently defined histopathological HD-OCT correlates of basal cell carcinomas (BCC) and possible predictors for the most common tumour subtypes. Methods For HD-OCT imaging, we used the Skintell ® device (Agfa Healthcare, Mortsel, Belgium). Twenty-five BCCs were histopathologically (including vertical as well horizontal haematoxylin and eosin and Alcian blue sectioning) confirmed and correlated with HD-OCT images. Results In the en-face mode, lobulated nodules were seen in 21 of the 25 lesions (84%), peripheral rimming in 18 (25/72 ...

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      Mentions: Thilo Gambichler AGFA Healthcare AGFA SKINTELL

    17. Optical coherence tomography: a reliable alternative to invasive histological assessment of acute wound healing in human skin?

      Explore Wiley Online Library Dermatology
      Optical coherence tomography: a reliable alternative to invasive histological assessment of acute wound healing in human skin?

      Background Gold standard assessment of acute wound healing has traditionally been through histological analysis of biopsied tissue. However, this process is invasive with recognised side-effects. Optical coherence tomography (OCT) is a non-invasive technique generating high resolution real-time images of cutaneous architecture. Objective To compare OCT with histological assessment of in-vivo acute wound healing and ascertain level of agreement between modalities for measurement of defined cutaneous structures. Methods 5mm punch biopsies were harvested from 50 healthy volunteers. Wounds healed by secondary intention until they were re-excised 7, 14, 21 or 28 days later depending on random group allocation. Wounds were assessed ...

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      Mentions: University of Manchester

    18. Non Invasive Diagnostic Techniques in Clinical Dermatology (Textbook)

      Explore Home - Springer Dermatology , Textbooks
      Non Invasive Diagnostic Techniques in Clinical Dermatology (Textbook)

      Optical coherence tomography (OCT) is a noninvasive imaging method. Using infrared broadband light sources, images of superficial skin layers can be obtained in vivo and real time. In dermatology, OCT can be used for investigation of skin tumors and inflammatory skin diseases, for quantification of skin changes, and for evaluation of treatment effects

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    20. Skin Evaluation Method And Skin Evaluation Device

      Explore patentscope.wipo.int Dermatology , Patents
      Skin Evaluation Method And Skin Evaluation Device

      A profile is created on the basis of an interference signal obtained by optical coherence tomography, the profile having optical reflectance in relation to depth in a depth range that extends from the epidermis to the dermal upper layer. The difference between a reflectance (R1) at a minimum point (P1) and a reflectance (R2) at a maximum point (P2) is calculated from the created profile to obtain an evaluation index. The state of skin is evaluated on the basis of the evaluation index.

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      Mentions: Fujifilm Medical Systems

    21. Optical Coherence Tomography Imaging of Non-melanoma Skin Cancer Undergoing Photodynamic Therapy Reveals Subclinical Residual Lesions

      Explore ScienceDirect Dermatology
      Optical Coherence Tomography Imaging of Non-melanoma Skin Cancer Undergoing Photodynamic Therapy Reveals Subclinical Residual Lesions

      Background Photodynamic therapy with methyl aminolaevulinate (MAL-PDT) is a widely used non-invasive treatment modality for non-melanoma skin cancer (NMSC). The outcome of MAL-PDT is usually primarily evaluated clinically. Optical coherence tomography (OCT) is a non-invasive imaging technology based on interferiometry. OCT has been proven to provide high accuracy in identifying NMSC lesions and performing thickness measurements of thin tumours. Objectives To describe the OCT morphology in in-vivo NMSC lesions during MAL-PDT treatment and to investigate the use of OCT in evaluating the response of MAL-PDT treated NMSC lesions Methods A total of 18 biopsy-proven basal cell carcinomas and actinic keratoses ...

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      Mentions: Mette Mogensen University of Copenhagen Gregor B. E. Jemec

    22. Uses of non-invasive imaging in the diagnosis of skin cancer: an overview of the currently available modalities

      Explore Wiley Online Library Dermatology
      Uses of non-invasive imaging in the diagnosis of skin cancer: an overview of the currently available modalities

      Background Emerging tools for the diagnosis of skin cancer are non-invasive imaging devices that allow for skin visualization without biopsy. While the capabilities of non-invasive imaging tools are far-reaching, each varies in its resolution depth, image clarity, clinical applicability, accuracy, sensitivity, and specificity. Objective The objective of this review is to evaluate non-invasive imaging modalities, and examine their capabilities, conditions for use, clinical applications, and limitations. Materials and methods A literature review was conducted on Pubmed using the search term “non-invasive diagnostic imaging tools and skin”. Relevant citations suggested by Pubmed were included. Each non-invasive imaging tool evaluated was also ...

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    23. CAPTURING THE VITAL VASCULAR FINGERPRINT WITH OPTICAL COHERENCE TOMOGRAPHY

      Explore bli.uci.edu Dermatology , Other Non-Medical
      CAPTURING THE VITAL VASCULAR FINGERPRINT WITH OPTICAL COHERENCE TOMOGRAPHY

      Using fingerprints as a method to identify an individual has been accepted in forensics since the 19 th century, and the fingerprint has become one of the most widely used biometric characteristics. Most of the modern fingerprint recognition systems are based on the print pattern of the finger surface and are not robust against spoof attaching. There may be problems where there are scars or cuts on fingertips. Optical coherence tomography (OCT) is a noncontact imaging technique which can capture high resolution, 3D images from within highly scattering biological tissues. There has been great interest to use OCT for fingerprint ...

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    24. Feature Of The Week 11/17/13: Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

      Explore Optical Coherence Tomography News Dermatology
      Feature Of The Week 11/17/13: Monitoring of wound healing process of human skin after fractional laser treatments with optical coherence tomography

      Fractional photothermolysis induced by non-ablative fractional lasers (NAFLs) or ablative fractional lasers (AFLs) can remodel the skin, regenerate collagen, and remove tumor tissue. However, fractional laser treatments may result in severe side effects, and multiple treatments are required to achieve the expected outcome. Thus, the treatment outcome and downtime after fractional laser treatments are key issues to determine the following treatment strategy. In this study, an optical coherence tomography (OCT) system was implemented for in vivo studies of wound healing after NAFL and AFL treatments. According to the OCT scanning results, the laser-induced photothermolysis including volatilization and coagulation could be ...

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      Mentions: Meng-Tsan Tsai Chang Gung University Feng-Yu Chang
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    1. (2 articles) Jürgen Lademann
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