1. Articles in category: Dermatology

    1-24 of 446 1 2 3 4 ... 17 18 19 »
    1. Michelson Diagnostics to present at Fortbildungswoche, Munich

      Michelson Diagnostics to present at Fortbildungswoche, Munich

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces that leading experts in the use of optical technology in dermatology will be presenting the benefits of multi-beam OCT at the 24th Annual Education Week for Practical Dermatology and Venereology, known as Fortbildungswoche, in Munich, Germany, 19-25 July 2014. The conference session on ‘Evidence for OCT diagnostics’ will take place at 12:15-13:15, Forum 9, on Friday 25th July. The presentations include: Optical coherence tomography scientific fundamentals and applications, Dr. Martina Ulrich Optical coherence tomography for basal cell carcinoma, Prof. Dr ...

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    2. Optical coherence tomography imaging of erythematotelangiectatic rosacea during treatment with brimonidine topical gel 0.33%: a potential method for treatment outcome assessment

      Optical coherence tomography imaging of erythematotelangiectatic rosacea during treatment with brimonidine topical gel 0.33%: a potential method for treatment outcome assessment

      BACKGROUND: Patients with moderate to severe rosacea often seek treatment to reduce erythema and vascular markings. Few studies have looked at the effectiveness of the novel treatment, brimonidine topical gel 0.33%, trademark name Mirvaso®, in the treatment of rosacea. We report the use of optical coherence tomography (OCT) scanning to monitor the effectiveness of Mirvaso® on in vivo skin. OCT is a non-invasive optical imaging technique that can provide high-resolution imaging of vessel and cellular morphology. OCT may be useful as a pre-treatment assessment tool for identifying possible morphologic features in the skin that may serve as outcome predictors ...

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    3. Doppler optical coherence tomography for microcirculation studies (Thesis)

      Doppler optical coherence tomography for microcirculation studies (Thesis)

      This thesis forms part of an ongoing long-term project to investigate the suitability of Doppler optical coherence tomography (OCT) as a measurement tool to investigate skin thickness and blood flow in patients with systemic sclerosis. There is a discussion of the characterisation of an electro-optic phase modulator for use in a Doppler OCT imaging system which is being built for the purpose of clinical studies. In addition to this the development of software for the same system is described. The work includes a comparison of two methods of obtaining Doppler information that were tested with the system; a phase resolved ...

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    4. Noninvasive monitoring of basal cell carcinomas treated with systemic hedgehog inhibitors: Pseudocysts as a sign of tumor regression

      Noninvasive monitoring of basal cell carcinomas treated with systemic hedgehog inhibitors: Pseudocysts as a sign of tumor regression

      Background Oral hedgehog inhibitors (HHIs) have shown significant efficacy in the treatment of basal cell carcinoma (BCC). The evaluation of tumor regression has been performed using clinical photography and radiographic scans. Noninvasive imaging techniques, such as reflectance confocal microscopy (RCM) and high-definition optical coherence tomography (HD-OCT), have been shown to be valuable in detecting BCC in the skin. Objective We monitored HHI-treated BCC using RCM and HD-OCT in vivo and correlated morphologic changes seen on imaging to changes in traditional histopathology. Methods Six BCCs in 5 patients receiving HHIs (vismodegib or sonidegib) were examined by RCM and HD-OCT before and ...

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    5. Feature Of The Week 6/8/14: Automated Registration of OCT and Dermoscopy in the Assessment in Basal Cell Carcinoma

      Feature Of The Week 6/8/14: Automated Registration of OCT and Dermoscopy in the Assessment in Basal Cell Carcinoma

      Optical coherence tomography (OCT) has been shown to be of clinical value in imaging basal cell carcinoma (BCC). A novel dual OCT-video imaging system, providing automated registration of OCT and dermoscopy, has been developed to assess the potential of OCT in measuring the degree of sub-clinical spread of BCC. Seventeen patients selected for Mohs micrographic surgery (MMS) for BCC were recruited to the study. The extent of BCC infiltration beyond a segment of the clinically assessed pre-surgical border was evaluated using OCT. Sufficiently accurate (<0.5 mm) registration of OCT and dermoscopy images was achieved in 9 patients. The location ...

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    6. Sun protection and hydration of stratum corneum: a study by 2D differential method

      Sun protection and hydration of stratum corneum: a study by 2D differential method

      The stratum corneum (written SC in the following) is the outermost layer of the epidermis and serves as a barrier against environmental aggression, such as infection, dehydration or sun damages. Within the SC, death cells called corneocytes, linked by an intercellular bridge called desmosomes, form layers. Depending on the body part and environmental factors, the number of layers and the thickness of each one can vary.

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    7. High frequency ultrasonography but not 930nm-optical coherence tomography reliably evaluates melanoma thickness in vivo: a prospective validation study.

      High frequency ultrasonography but not 930nm-optical coherence tomography reliably evaluates melanoma thickness in vivo: a prospective validation study.

      Background Early diagnosis and rapid surgical excision are essential for improving the prognosis of melanoma patients. Reflectance confocal microscopy has been validated as a feasible procedure for in vivo diagnosis of melanoma but cannot be used to measure tumour thickness. However, ultrasonography and optical coherence tomography may allow melanoma thickness to be measured in vivo . Objectives Primary: To validate the accuracy and reliability of high-frequency ultrasonography and optical coherence tomography for assessing melanoma thickness in vivo . Methods We conducted a prospective study on 131 patients with at least one equivocal melanocytic lesion. Each lesion underwent optical coherence tomography and high-frequency ...

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    8. OCT Developments Address Skin

      OCT Developments Address Skin

      Recent developments in optical coherence tomography (OCT) address skin cancer diagnosis. MedLumics (Madrid, Spain) has launched a three-year initiative to translate research into new clinical applications—with help from $4.9 million (€3.6 million) in Series A funding from EU joint investors. Called the BiopsyPen Project, the initiative is led by MedLumics and the Medical University of Vienna (Austria), along with European members including VTT Finland (Espoo, Finland), Delft University of Technology in The Netherlands, Exalos (Schlieren, Switzerland), the Polytechnic University of Madrid, and Optocap (Livingston, Scotland). The organizations are working to develop a handheld system for point-of-care diagnosis ...

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    9. Characterization of Optical Coherence Tomography Images Acquired at Large Distances With Large-Diameter Beams

      Characterization of Optical Coherence Tomography Images Acquired at Large Distances With Large-Diameter Beams

      We tested the imaging capabilities for variants of a 1550-nm swept-source fiber-based optical coherence tomography system with a telecentric system incorporated at the end of its sample arm. The system was designed for in vivo imaging of burns; therefore, we acquired images from samples located at distances greater than 24 cm from the exit of the telecentric system. Each system variation had a specific combination of diameters for the reference and sample beams. In the reference arm, we used, alternately, two collimated beams with diameters of 1.5 and 14 mm, respectively. In the sample arm, we tested collimated beams ...

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    10. New study on non-invasive diagnosis of non-melanoma skin cancer with Melanoma Institute of Australia

      New study on non-invasive diagnosis of non-melanoma skin cancer with Melanoma Institute of Australia

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, has commenced a clinical study to investigate the use of OCT to diagnose basal cell carcinoma in collaboration with the Melanoma Institute of Australia using Michelson’s Diagnostics VivoSight system. The study, run by Dr Pascale Guitera FACD PhD, will evaluate VivoSight’s ability to triage lesions which are superficial enough to be treated non-invasively and monitor the success, or otherwise, of non-invasive therapies. The study is designed to determine the potential to change clinical practice towards more non-invasive treatments of basal cell carcinoma ...

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    11. Optical coherence tomography microangiography for monitoring the response of vascular perfusion to external pressure on human skin tissue

      Optical coherence tomography microangiography for monitoring the response of vascular perfusion to external pressure on human skin tissue

      Characterization of the relationship between external pressure and blood flow is important in the examination of pressure-induced disturbance in tissue microcirculation. Optical coherence tomography (OCT)-based microangiography is a promising imaging technique, capable of providing the noninvasive extraction of functional vessels within the skin tissue with capillary-scale resolution. Here, we present a feasibility study of OCT microangiography (OMAG) to evaluate changes in blood perfusion in response to externally applied pressure on human skin tissue in vivo . External force is loaded normal to the tissue surface at the nailfold region of a healthy human volunteer. An incremental force is applied step ...

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    12. A complex noise reduction method for improving visualization of SD-OCT skin biomedical images

      A complex noise reduction method for improving visualization of SD-OCT skin biomedical images

      In this paper we consider the original method of solving noise reduction problem for visualization’s quality improvement of SD-OCT skin and tumors biomedical images. The principal advantages of OCT are high resolution and possibility of in vivo analysis. We propose a two-stage algorithm: 1) process of raw one-dimensional A-scans of SD-OCT and 2) remove a noise from the resulting B(C)-scans. The general mathematical methods of SD-OCT are unstable: if the noise of the CCD is 1.6% of the dynamic range then result distortions are already 25-40% of the dynamic range. We use at the first stage ...

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      Mentions: Pavel Zakharov
    13. Michelson Diagnostics to present at EuroMedtech 2014

      Michelson Diagnostics to present at EuroMedtech 2014

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces that Chief Executive Officer, Jon Holmes, will be presenting an overview of the Company at the 6 th Annual International Medtech Partnering Conference, EuroMedtech™ 2014, in Linz, Austria, 7-8 May 2014. EuroMedtech is Europe's leading medical technology partnering conference, providing collaboration opportunities to medtech decision makers and investors. The conference provides a platform for innovative companies interested in partnering their technologies or products, initiating strategic alliances, or tapping into the international financing network. In addition, early stage projects and small entrepreneurial ...

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    14. Automated registration of optical coherence tomography and dermoscopy in the assessment of sub-clinical spread in basal cell carcinoma

      Automated registration of optical coherence tomography and dermoscopy in the assessment of sub-clinical spread in basal cell carcinoma

      Optical coherence tomography (OCT) has been shown to be of clinical value in imaging basal cell carcinoma (BCC). A novel dual OCT-video imaging system, providing automated registration of OCT and dermoscopy, has been developed to assess the potential of OCT in measuring the degree of sub-clinical spread of BCC. Seventeen patients selected for Mohs micrographic surgery (MMS) for BCC were recruited to the study. The extent of BCC infiltration beyond a segment of the clinically assessed pre-surgical border was evaluated using OCT. Sufficiently accurate (<0.5 mm) registration of OCT and dermoscopy images was achieved in 9 patients. The location ...

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    15. Modern non-invasive diagnostic techniques in the detection of early cutaneous melanoma

      Modern non-invasive diagnostic techniques in the detection of early cutaneous melanoma

      Over the past few years melanoma has grown into a disease of socio-economic importance due to the increasing incidence and persistently high mortality rates. Melanoma is a malignant tumor with a high tendency to metastasize. Therefore, an extremely important part of the therapeutic process is to identify the disease at an early stage: in situ or stage I. Many tools for early diagnosis of melanoma are available today, including dermoscopy, videodermoscopy and in vivo reflectance confocal microscopy. Other methods such as high frequency ultrasound, optical coherence tomography and electrical impedance spectroscopy may serve as additional diagnostic aids. Modern imaging techniques ...

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    16. Experimental research and observation of the skin response of mice with a second-degree scald duringirradiation by a CO 2 laser

      Experimental research and observation of the skin response of mice with a second-degree scald duringirradiation by a CO 2 laser

      Second-degree scalding is a common dermatological injury. Inappropriate treatment methods in clinical practice always produce scarring, and can lead to skin cancer and other complications in the longer term. In this study optical coherence tomography (OCT) combined with a skin detector was used to monitor the response of second-degree scalded skin tissue irradiated by a CO2 laser. The process of treatment of second-degree scalding was systematically studied from the perspective of tissue optics. The OCT signal intensity was stronger within the whole recovery period in the experimental group undergoing CO2 laser treatment, and the attenuation coefficient (μt) returned ...

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    17. Parallelized multi–graphics processing unit framework for high-speed Gabor-domain optical coherence microscopy

      Parallelized multi–graphics processing unit framework for high-speed Gabor-domain optical coherence microscopy

      Gabor-domain optical coherence microscopy (GD-OCM) is a volumetric high-resolution technique capable of acquiring three-dimensional (3-D) skin images with histological resolution. Real-time image processing is needed to enable GD-OCM imaging in a clinical setting. We present a parallelized and scalable multi-graphics processing unit (GPU) computing framework for real-time GD-OCM image processing. A parallelized control mechanism was developed to individually assign computation tasks to each of the GPUs. For each GPU, the optimal number of amplitude-scans (A-scans) to be processed in parallel was selected to maximize GPU memory usage and core throughput. We investigated five computing architectures for computational speed-up in processing ...

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    18. MedLumics Announces “BiopsyPen Project” with €3.6M EU in Funding; Initiative Aimed at New Clinical Applications for Optical Coherence Tomography

      MedLumics Announces “BiopsyPen Project” with €3.6M EU in Funding; Initiative Aimed at New Clinical Applications for Optical Coherence Tomography

      MedLumics , a medical imaging company specializing in advanced optical coherence tomography (OCT) technology, today announced the kick off of a three-year initiative to translate the latest OCT research into new clinical applications. Called the “BiopsyPen Project,” the effort is led by MedLumics and the Medical University of Vienna, with participation from a consortium of European members including VTT Finland, Delft University of Technology, Exalos AG, the Polytechnic University of Madrid, and Optocap Ltd. Together, the organizations are working to develop the second generation of a compact handheld diagnostic imaging system that will radically transform the capability of biophotonic technologies for ...

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    19. Spectroscopic study on appearances of make-up skins using a visible RGB-LED OCT

      Spectroscopic study on appearances of make-up skins using a visible RGB-LED OCT

      Background/purpose Facial foundation is very effective to correct color irregularities of the skin surface and to protect the skin from harmful light. This depends strongly on both the optical properties and the coating condition of foundation on the skin surface. Methods We constructed the full-field optical coherence tomography (OCT) (FF-OCT) microscope with visible light sources of RGB LEDs. The commercially available skin replicas were used as the model of skin in the experiment, which were composed of two layers, a thin polyurethane film transcribed from cheek surface of a female and a beige-colored silicone substrate. The foundations were applied ...

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    20. Positive top line results from clinical trial for diagnosis of basal cell carcinoma using VivoSight OCT

      Positive top line results from clinical trial for diagnosis of basal cell carcinoma using VivoSight OCT

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, announces positive top line results from the successfully completed multi-centre, prospective clinical trial for the diagnosis of basal cell carcinoma using VivoSight OCT. In the study, over 250 patients with clinically suspicious lesions for basal cell carcinoma were scanned at six centres in Germany. In each case, diagnosis using VivoSight OCT was compared with standard clinical diagnosis with and without dermoscopy. All results were verified by the gold standard of biopsy and histological analysis. Papers by Professor Dr. med. Julia Welzel, Dr. med. Martina ...

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    21. Positive results from multi-centre, prospective clinical trial for diagnosis of basal cell carcinoma using Michelson Diagnostics’ VivoSight OCT Presented at AAD

      Positive results from multi-centre, prospective clinical trial for diagnosis of basal cell carcinoma using Michelson Diagnostics’ VivoSight OCT Presented at AAD

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces positive results from the successfully completed multi-centre, prospective clinical trial for the diagnosis of basal cell carcinoma using VivoSight OCT to be presented at the upcoming American Academy of Dermatology’s 72nd Annual Meeting (AAD) in Denver, Colorado, 21-25 March 2014. Papers by Professor Dr. med. Julia Welzel, Dr. med. Martina Ulrich discussing results from the clinical study will be presented in the AAD Conference Session F153 “Non-Invasive Imaging in Dermatology” on Tuesday, 25 March at 1.00pm. The presented results support ...

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    22. Optical coherence tomography using images of hair structure and dyes penetrating into the hair

      Optical coherence tomography using images of hair structure and dyes penetrating into the hair

      Background/purpose Hair dyes are commonly evaluated by the appearance of the hair after dyeing. However, this approach cannot simultaneously assess how deep the dye has penetrated into hair. Methods For simultaneous assessment of the appearance and the interior of hair, we developed a visible-range red, green, and blue (RGB) (three primary colors)-optical coherence tomography (OCT) using an RGB LED light source. We then evaluated a phantom model based on the assumption that the sample's absorbability in the vertical direction affects the tomographic imaging. Results Consistent with theory, our device showed higher resolution than conventional OCT with far-red ...

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    23. Hydrogel-Forming Microneedles Increase in Volume During Swelling in Skin, but Skin Barrier Function Recovery is Unaffected

      Hydrogel-Forming Microneedles Increase in Volume During Swelling in Skin, but Skin Barrier Function Recovery is Unaffected

      We describe, for the first time, quantification of in-skin swelling and fluid uptake by hydrogel-forming microneedle (MN) arrays and skin barrier recovery in human volunteers. Such MN arrays, prepared from aqueous blends of hydrolyzed poly(methylvinylether/maleic anhydride) (15%, w/w) and the cross-linker poly(ethyleneglycol) 10,000 Da (7.5%, w/w), were inserted into the skin of human volunteers ( n = 15) to depths of approximately 300 μm by gentle hand pressure. The MN arrays swelled in skin, taking up skin interstitial fluid, such that their mass had increased by approximately 30% after 6 h in skin. Importantly, however ...

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    24. High resolution in-vivo imaging of skin with full field optical coherence tomography

      High resolution in-vivo imaging of skin with full field optical coherence tomography

      Full-field OCT (FFOCT) has the ability to provide en-face images with a very good axial sectioning as well as a very high transverse resolution (about 1 microns in all directions). Therefore it offers the possibility to visualize biological tissues with very high resolution both on the axial native view, and on vertical reconstructed sections. Here we investigated the potential dermatological applications of in-vivo skin imaging with FFOCT. A commercial FFOCT device was adapted for the in-vivo acquisition of stacks of images on the arm, hand and finger. Several subjects of different benign and pathological skin conditions were tested. The images ...

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