Dermatology -Optical Coherence Tomography News

Articles in category: Dermatology

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1. Dynamic Optical Coherence Tomography(D-OCT) Aging Study: A Preliminary Evaluation of Structural Differences Between Young and Aged Skin, Cellulite and Atrophic Acne Scars in Female Caucasian Subjects With Fitzpatrick Skin Types I-III Utilizing Non-invasiv
  
  Explore Home - ClinicalTrials.gov Dec 6 2018 Dermatology , Clinical Trials
  
  This single-center clinical study is being conducted over the course of 2 weeks to conduct an exploratory pilot study as a preliminary evaluation of D-OCT's ability to measure skin changes from aging. Assess structural differences between young and aged skin on the face. To identify the structural characteristics of atrophic acne scars relative to normal skin on the face. To explore characteristics of cellulite relative to normal skin on the thigh in young and aged skin.
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2. OCT links blood vessels to melanoma type
  
  Explore optics.org Dec 6 2018 Dermatology , Oncology
  
  A clinical study of malignant melanoma suggests that optical imaging of the most aggressive form of skin cancer could yield a faster assessment of particularly dangerous tumors. According to the UK-based optical coherence tomography (OCT) hardware developer Michelson Diagnostics , whose equipment was used in the study by four European dermatology research groups, the technique could offer a “short-cut” to identifying advanced cancers that have begun to spread. That might provide patients with a more aggressive or advanced tumor access to appropriate treatment more quickly, while those with less virulent melanomas could be spared invasive and expensive sentinel lymph-node biopsies that ...
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  Mentions: Michelson Diagnostics
3. Michelson Diagnostics: Imaging Reveals Changes in Blood Vessel Growth in Deadly Melanoma Skin Cance
  
  Explore Optical Coherence Tomography News Dec 3 2018 Dermatology , Other Business News
  
  A new clinical study has shown that Dynamic Optical Coherence Tomography imaging of melanomas (D-OCT) reveals changes to the blood vessels that correlate with the depth of invasion of the melanoma. Researchers believe this could lead to a new faster method of rapidly assessing how dangerous a given melanoma is. A more rapid assessment of the risk would potentially allow patients with more serious invasive disease access to the right treatment more directly, doing away with delays inherent in the traditional diagnosis. The technique may also lead to reducing the number of patients with less aggressive tumours receiving sentinel lymph ...
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  Mentions: Michelson Diagnostics Jon Holmes University of Copenhagen
4. Usefulness of Optical Coherence Tomography in the Preoperative Assessment of Nail Deformities
  
  Explore Archives of Aesthetic Plastic Surgery Nov 3 2018 Dermatology
  
  Secondary nail deformities are often seen at some time after fingertip and nail bed injuries. A proper evaluation of the fingernail enables appropriate diagnosis and treatment, especially in patients who need surgical management. To date, ultrasound and magnetic resonance imaging are the only diagnostic tools that most surgeons use in cases of nail deformities. Herein, we report the case of a patient with a nail deformity who underwent successful correction based on the preoperative use of real-time optical coherence tomography.
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  Mentions: University of Ulsan
5. Classification of burn injury using Raman spectroscopy and optical coherence tomography: An ex-vivo study on porcine skin
  
  Explore ScienceDirect Nov 1 2018 Dermatology
  
  Accurate depth assessment of burn wounds is a critical task to provide the right treatment and care. Currently, laser Doppler imaging is able to provide better accuracy compared to the standard clinical evaluation. However, its clinical applicability is limited by factors like scanning distance, time, and cost. Precise diagnosis of burns requires adequate structural and functional details. In this work, we evaluated the combined potential of two non-invasive optical modalities, optical coherence tomography (OCT) and Raman spectroscopy (RS), to identify degrees of burn wounds (superficial partial-thickness (SPT), deep partial-thickness (DPT), and full-thickness (FT)). OCT provides morphological information, whereas, RS provides ...
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  Mentions: Vanderbilt University Anita Mahadevan-Jansen
6. Handheld Skin Quality Optical Coherence Tomography
  
  Explore YouTube Oct 28 2018 Dermatology
  
  ITRI’s Handheld Skin Quality Optical Coherence Tomography (HSQ-OCT) is the first to provide real-time, non-invasive, easily operated, objective evaluation of skin quality. It is the first handheld OCT system scientifically proven capable of visualizing subsurface skin structures and detecting collagen distribution in the dermis layer. This technology makes it possible to conduct automatic and objective evaluation of skin quality, revealing the effects of skincare products and providing reliable scientific evidence for testing. Further, it reduces the need to sacrifice experimental animals for cosmetic product development.
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7. Line-field confocal optical coherence tomography for high-resolution noninvasive imaging of skin tumors
  
  Explore SPIE Digital Library Oct 27 2018 Dermatology
  
  An optical technique called line-field confocal optical coherence tomography (LC-OCT) is introduced for high-resolution, noninvasive imaging of human skin in vivo . LC-OCT combines the principles of time-domain optical coherence tomography and confocal microscopy with line illumination and detection using a broadband laser and a line-scan camera. LC-OCT measures the echo-time delay and amplitude of light backscattered from cutaneous microstructures through low-coherence interferometry associated with confocal spatial filtering. Multiple A-scans are acquired simultaneously while dynamically adjusting the focus. The resulting cross-sectional B-scan image is produced in real time at 10 frame / s. With an isotropic spatial resolution of ∼1 μm, the ...
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  Mentions: Arnaud Dubois Damae Medical
8. A review of non‐invasive imaging in extramammary Paget's disease
  
  Explore Wiley Online Library Oct 27 2018 Dermatology
  
  Extramammary Paget's Disease (EMPD) is a rare intraepithelial adenocarcinoma that classically manifests with pruritic, erythematous and scaling plaques. The clinical picture frequently mimics inflammatory or infectious conditions and is thus commonly misdiagnosed. The assessment of tumour margins is equally challenging as tumours have a propensity to spread beyond clinically visible boundaries. Appropriate non‐invasive diagnostic tools can assist in the early detection, diagnosis and management of EMPD. This paper will review the literature on non‐invasive imaging modalities used in EMPD. Articles from the PubMed database were selected based on relevance to the topic of this review. Articles that ...
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9. Inherited epidermolysis bullosa: description of clinical and subclinical morphological features with optical coherence tomography
  
  Explore Wiley Online Library Oct 25 2018 Dermatology
  
  Epidermolysis bullosa (EB) is an inherited skin disorder characterized by exacerbated skin and/or mucosal fragility and blister formation following minor mechanical trauma. Great scientific interest has recently been focused on gene therapies and transgenic epidermal grafting in EB patients. 1 Depending on the level of cleavage in the skin, EB is classified into 4 types: simplex (EBS), junctional (JEB), and dystrophic (DEB), and the extremely rare Kindler syndrome
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10. Optical coherence tomography provides an optical biopsy of burn wounds in children—a pilot study
  
  Explore SPIE Digital Library Oct 24 2018 Dermatology
  
  Thermic injuries are among the most severe injuries in childhood. Burn depth is the most relevant prognostic factor, and still its assessment is both difficult and controversial. This diagnostic uncertainty results in repeated wound assessments over a 10-day period and carries a relevant risk for over- and undertreatment. Precise wound assessment would thus be a significant step toward improved care. Optical coherence tomography (OCT) is a noninvasive laser-based technique with a penetration depth of ∼2 mm. It provides structural images of the skin while dynamic OCT (D-OCT) shows blood vessels. In this study, we investigated burns and scalds in 130 ...
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  Mentions: University of Lübeck Julia Welzel
11. Preclinical quantitative in-vivo assessment of skin tissue vascularity in radiation-induced fibrosis with optical coherence tomography
  
  Explore SPIE Digital Library Oct 16 2018 Dermatology
  
  Radiation therapy (RT) is widely and effectively used for cancer treatment but can also cause deleterious side effects, such as a late-toxicity complication called radiation-induced fibrosis (RIF). Accurate diagnosis of RIF requires analysis of histological sections to assess extracellular matrix infiltration. This is invasive, prone to sampling limitations, and thus rarely used; instead, current practice relies on subjective clinical surrogates, including visual observation, palpation, and patient symptomatology questionnaires. This preclinical study demonstrates that functional optical coherence tomography (OCT) is a useful tool for objective noninvasive in-vivo assessment and quantification of fibrosis-associated microvascular changes in tissue. Data were collected from murine ...
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  Mentions: University of Toronto I. Alex Vitkin Costel Flueraru
12. Quantitative evaluation of skin surface roughness using optical coherence tomography in vivo
  
  Explore IEEE Xplore Oct 13 2018 Dermatology
  
  The quantitative monitoring of skin topography is important in the field of cosmetics and dermatology. The most widespread method for determining skin roughness in vivo is to use skin microrelief, PRIMOS device, which allows a noninvasive, fast and direct measurement of the skin surface. However, it has drawbacks, such as the interference of backscattering from volumetric skin and motion artifacts. In this study, we demonstrate the potential of OCT for providing reliable and quantitative skin surface roughness. In order to evaluate the performance of OCT for skin surface analysis, different types of skin phantoms were fabricated and measured. We utilized ...
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  Mentions: University of Ulsan Kyungpook National University
13. Gabor-Domain Optical Coherence Tomography to Aid in Mohs Resection of Basal Cell Carcinoma
  
  Explore jaad.org Oct 6 2018 Dermatology
  
  No abstract provided.
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  Mentions: University of Rochester Jannick P. Rolland
14. Omiganan Twice a Day (BID) in Patients With Facial Seborrheic Dermatitis
  
  Explore Home - ClinicalTrials.gov Sep 28 2018 Dermatology , Clinical Trials
  
  To explore the efficacy and pharmacodynamic effects of omiganan topical gel in facial seborrheic dermatitis.
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15. Three‐dimensional nail imaging by optical coherence tomography: a novel biomarker of response to therapy for nail disease in psoriasis and psoriatic arthritis
  
  Explore Wiley Online Library Sep 25 2018 Dermatology
  
  No abstract provided.
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16. The vascular morphology of melanoma is related to Breslow index: an in vivo study with dynamic optical coherence tomography
  
  Explore Wiley Online Library Sep 20 2018 Dermatology
  
  Background Malignant melanoma is an aggressive skin cancer, which can lead to metastasis development. Vascularization enhancement is fundamental for tumor growth, worsening the prognosis. Dynamic Optical Coherence Tomography (D‐OCT) enables the in vivo evaluation of vascular patterns in skin lesions. Objective In vivo evaluation of the melanoma vessel morphology by means of D‐OCT and correlation with Breslow index. Methods Retrospective analysis of histologically proven melanomas, evaluated by D‐OCT at three different depths (150, 300 and 500 μm) was performed. Vessels were classified according to morphology (dots, blobs, coiled, line, curved, serpiginous), distribution (regular, irregular), and presence/type ...
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  Mentions: Michelson Diagnostics Jon Holmes University of Copenhagen
17. The utility of optical coherence tomography for diagnosis of basal cell carcinoma: A quantitative review
  
  Explore Wiley Online Library Sep 14 2018 Dermatology , Oncology
  
  Background Optical coherence tomography (OCT) is a non‐invasive near‐infrared light imaging technology that can be utilized to diagnose basal cell carcinomas (BCCs) based on specific morphologic features. Objectives To conduct a quantitative review using tumor level data from published studies to assess i) in‐vivo diagnostic accuracy of different OCT systems; ii) correlation between OCT features and histopathological diagnosis; and iii) factors that impact accuracy of tumor depth estimation. Methods Primary tumor‐level data were extracted from published studies on use of time‐domain (TD‐OCT), frequency‐domain (FD‐OCT) or high‐definition (HD‐OCT) systems for diagnosis ...
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18. In vivo Micro-Tomographic Visualization of Capillary Angio-Dynamics Around Upper Dermis Under Mechanical Stimulus Using Low Coherence Interferometer “Optical Coherence Doppler Velocigraphy”
  
  Explore Science Publishing Group Sep 10 2018 Dermatology
  
  The skin aging process, e.g. wrinkles and sagging, caused by not only aging but also ultraviolet irradiation, could be related to the depression of metabolic function. Therefore, an in vivo quantitative measurement of capillary blood flow velocity governing skin metabolism functionally, i.e. microcirculation, is crucial to clarify the skin aging and to create skincare products. The purpose of this study is to visualize the tomographic velocity of red blood cell in capillaries just below human epidermal skin using Optical Coherence Doppler Velocigraphy, namely OCDV. This was constructed on a low coherence interferometer, which could provide tomographic distribution of ...
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  Mentions: Osaka University
19. Evaluation of a Combined Reflectance Confocal Microscopy–Optical Coherence Tomography Device for Detection and Depth Assessment of Basal Cell Carcinoma
  
  Explore The JAMA Network Aug 28 2018 Dermatology
  
  Importance The limited tissue sampling of a biopsy can lead to an incomplete assessment of basal cell carcinoma (BCC) subtypes and depth. Reflectance confocal microscopy (RCM) combined with optical coherence tomography (OCT) imaging may enable real-time, noninvasive, comprehensive three-dimensional sampling in vivo, which may improve the diagnostic accuracy and margin assessment of BCCs. Objective To determine the accuracy of a combined RCM-OCT device for BCC detection and deep margin assessment. Design, Setting, and Participants This pilot study was carried out on 85 lesions from 55 patients referred for physician consultation or Mohs surgery at Memorial Sloan Kettering Skin Cancer Center ...
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  Mentions: Nicusor Iftimia
20. Visualization of skin microvascular dysfunction of type 1 diabetic mice using in vivo skin optical clearing method
  
  Explore SPIE Digital Library Aug 23 2018 Dermatology
  
  To realize visualization of the skin microvascular dysfunction of type 1 diabetic mice, we combined laser speckle contrast imaging and hyperspectral imaging to simultaneously monitor the noradrenaline (NE)-induced responses of vascular blood flow and blood oxygen with the development of diabetes through optical clearing skin window. The main results showed that venous and arterious blood flow decreased without recovery after injection of NE; furthermore, the decrease of arterious blood oxygen induced by NE greatly weakened, especially for 2- and 4-week diabetic mice. This change in vasoconstricting effect of NE was related to the expression of α1-adrenergic receptor. This study ...
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21. In vivo detection of UV-induced acute skin effects using optical coherence tomography
  
  Explore OSA | OSA Publishing Aug 20 2018 Dermatology
  
  Ultraviolet (UV) rays have been identified as a carcinogen with long-term irradiation and are an important risk factor for skin cancer. Here, we report the use of optical coherence tomography/optical coherence tomography angiography (OCT/OCTA) to study acute UV-induced effects on skin in vivo . To understand the relationship between the acute effects and irradiated UV power density, three groups were irradiated with different power densities in our experiments. Furthermore, the same skin area was repeatedly scanned with OCT during UV irradiation to investigate the progress of the induced acute effects and after irradiation for observation of skin recovery. Subsequently ...
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  Mentions: National Taiwan University Meng-Tsan Tsai Chang Gung University
22. A compact high‐speed full‐field optical coherence microscope for high‐resolution in vivo skin imaging
  
  Explore Wiley Online Library Aug 17 2018 Dermatology
  
  A compact high‐speed full‐field optical coherence microscope has been developed for high‐resolution in vivo imaging of biological tissues. The interferometer, in the Linnik configuration, has a size of 11×11×5 cm 3 and a weight of 210 g. Full‐field illumination with low‐coherence light is achieved with a high‐brightness broadband light‐emitting diode. High‐speed full‐field detection is achieved by using part of the image sensor of a high‐dynamic range CMOS camera. En face tomographic images are acquired at a rate of 50 Hz, with an integration time of 0.9 ms ...
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  Mentions: Arnaud Dubois Institut d'Optique
23. Effect of a Basic Skin Care Product on the Structural Strength of the Skin
  
  Explore Home - ClinicalTrials.gov Aug 10 2018 Dermatology , Clinical Trials
  
  The process of aging involves numerous structural and functional changes also affecting the skin. The skin fulfills a variety of protective and regulatory functions. Compared to other organs, the skin is constantly exposed to harmful environmental influences. Besides intrinsic factors these external factors may accelerate skin aging. Due to its ageing-related loss of functional capacity the skin becomes susceptible to develop adverse skin conditions and dermatological diseases (e.g. skin dryness, fungal infections). Especially old aged, care depended, and severely ill individuals are at high risk for developing severe skin injuries and wounds (e.g. decubitus, skin tears) with high ...
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24. Extracting Blood Vessels From Full-Field OCT Data of Human Skin by Short-Time RPCA
  
  Explore IEEE Xplore Aug 3 2018 Dermatology
  
  Recent advances in optical coherence tomography (OCT) lead to the development of OCT angiography to provide additional helpful information for diagnosis of diseases like basal cell carcinoma. In this paper, we investigate how to extract blood vessels of human skin from full-field OCT (FF-OCT) data using the robust principal component analysis (RPCA) technique. Specifically, we propose a short-time RPCA method that divides the FF-OCT data into segments and decomposes each segment into a low-rank structure representing the relatively static tissues of human skin and a sparse matrix representing the blood vessels. The method mitigates the problem associated with the slow-varying ...
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  Mentions: National Taiwan University Sheng-Lung Huang
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