1. Articles in category: Dermatology

    1-24 of 891 1 2 3 4 ... 36 37 38 »
    1. Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study

      Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study

      Patients undergo collection of tears, saliva, buccal mucosa, and fecal samples before stem cell transplant, at 2-3, 4, 6, 8, 10, and 12 months after stem cell transplant, and at cGVHD onset. Patients also undergo collection of blood samples before stem cell transplant, at 1-2, 2-3, 4, 6, 8, 10, and 12 months after stem cell transplant, and at cGVHD onset. Patients may undergo skin and mouth biopsy over 15-30 minutes before stem cell transplant, at 2-3 and 12 months after stem cell transplant, and at cGVHD onset. Patients undergo digital pictures of the eyes, mouth and skin, and optical ...

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    2. High-Resolution Optical Coherence Tomography (OCT) for Skin Imaging (Book Chapter)

      High-Resolution Optical Coherence Tomography (OCT) for Skin Imaging (Book Chapter)

      This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work. Imaging Technologies and Transdermal Delivery in Skin Disorders starts by outlining the structural characteristics of skin and skin appendages. It then discusses the key pathways involved in skin growth and development. Clinical ...

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    3. Capillary Refill—The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography

      Capillary Refill—The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography

      Background/Objectives: Standard optical coherence tomography angiography (OCTA) has been limited to imaging blood vessels actively undergoing perfusion, providing a temporary picture of surface microvasculature. Capillary perfusion in the skin is dynamic and changes in response to the surrounding tissue's respiratory, nutritional, and thermoregulatory needs. Hence, OCTA often represents a given perfusion state without depicting the actual extent of the vascular network. Here we present a method for obtaining a more accurate anatomic representation of the surface capillary network in human skin using OCTA, along with proposing a new parameter, the Relative Capillary Capacity (RCC), a quantifiable proxy for ...

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    4. Processing optical coherency tomography scans

      Processing optical coherency tomography scans

      A method of processing optical coherence tomography (OCT) scans through a subject's skin, the method comprising: receiving at least one OCT scan through the subject's skin, each scan representing an OCT signal in a slice through the subject's skin; processing each OCT scan so as to determine a set of parameters comprising at least a measure of the atrophy of the vascular structure in the epidermis; in which the processing produces a measurement of skin condition dependent upon each of the set of parameters, and the method comprises outputting the measurement of skin condition.

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    5. Skin Imaging using Ultrasound Imaging, Optical Coherence Tomography, Confocal Microscopy, and Two-Photon Microscopy in Cutaneous Oncology

      Skin Imaging using Ultrasound Imaging, Optical Coherence Tomography, Confocal Microscopy, and Two-Photon Microscopy in Cutaneous Oncology

      With the recognition of dermoscopy as a new medical technology and its available fee assessment in Korea comes an increased interest in imaging-based dermatological diagnosis. For the dermatologist, who treats benign tumors and malignant skin cancers, imaging-based evaluations can assist with determining the surgical method and future follow-up plans. The identification of the tumor’s location and the existence of blood vessels can guide safe treatment and enable the use of minimal incisions. The recent development of high-resolution microscopy based on laser reflection has enabled observation of the skin at the cellular level. Despite the limitation of a shallow imaging ...

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    6. OCT Image-Guided Treatment of Scars (Book Chapter)

      OCT Image-Guided Treatment of Scars (Book Chapter)

      Improved scar rehabilitation is achieved with lasers by matching laser settings to heterogeneous thickness of fibrous pathology. Optical coherence tomography (OCT) provides accurate depth measurement and demonstrates vascularity in scar and healthy tissue noninvasively providing a clinical endpoint for optimally calculating dosimetry. Real-time imaging during treatment allows personalized treatment due to varying collagen densities in cicatricial tissues

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    7. Nailfold capillaroscopy with a commercially available optical coherence tomography angiography for ophthalmic use

      Nailfold capillaroscopy with a commercially available optical coherence tomography angiography for ophthalmic use

      Visualising capillaries in the retina and the nailfold provides an opportunity to improve our understanding of various systemic disorders including cardiovascular, metabolic, rheumatic, and eye diseases.1–5 Traditional nailfold capillaroscopy has been primarily utilised, during the last 40 years, to study the vascular components of connective tissue diseases.6,7 It has been established as a safe and noninvasive diagnostic tool that allows high magnification view of skin microcirculation as well assessment of capillary density and blood flow velocity.8,9 In ophthalmology, a number of studies have been conducted to assess eye diseases and their relationship with nailfold ...

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    8. Use of Vibrational Optical Coherence Tomography to Image and Characterize a Squamous Cell Carcinoma

      Use of Vibrational Optical Coherence Tomography to Image and Characterize a Squamous Cell Carcinoma

      Previous literature reports suggest that tissue stiffness is a predictor of cancer and metastatic behavior. We have used optical coherence tomography and vibrational analysis (VOCT) to characterize normal skin, scar and a verrucous carcinoma, a squamous cell carcinoma subtype, non-invasively and nondestructively. The results suggest that epidermal thickening and increased keratin production occur in verrucous carcinoma and lead to increases in surface hills and valleys as well as subsequent increases in epidermal stiffness values. Increased stiffness of the epidermis is a result of increased keratin production while the stiffness of the dermis remains similar to that of normal skin, suggesting ...

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    9. Morphological parametric mapping of 21 skin sites throughout the body using optical coherence tomography

      Morphological parametric mapping of 21 skin sites throughout the body using optical coherence tomography

      Background Changes in body posture cause changes in morphological properties at different skin sites. Although previous studies have reported the thickness of the skin, the details of the postures are not generally given. This paper presents the effect of a change in posture on parameters such as thickness and surface roughness in 21 load-bearing and non-load-bearing sites. Materials and methods A total of 12 volunteers (8 males and 4 females) were selected in an age group of 18–35 years and of Fitzpatrick skin type I-III. Images were captured using a clinically-approved VivoSight® optical coherence tomography system and analysed using ...

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    10. Intraoperative Speckle Variance Optical Coherence Tomography for Tissue Temperature Monitoring During Cutaneous Laser Therapy

      Intraoperative Speckle Variance Optical Coherence Tomography for Tissue Temperature Monitoring During Cutaneous Laser Therapy

      Background: Tissue temperature monitoring during cutaneous laser therapy can lead to safer and more effective treatments. In this study, we investigate the use of speckle variance optical coherence tomography (svOCT) to monitor real-time temperature changes in the excised human skin tissue sample during laser irradiation. Methods: To accomplish this, we combined the pulse laser system with a reference-based svOCT system. To calibrate the svOCT, the ex-vivo human skin samples from three individuals with tissues collected from the arm, face, and back were heated with 1-degree increments. Additionally, linear regression was used to extract and evaluate the linear relationship between the ...

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    11. Presurgical evaluation of basal cell carcinoma using combined reflectance confocal microscopy-optical coherence tomography: A prospective study

      Presurgical evaluation of basal cell carcinoma using combined reflectance confocal microscopy-optical coherence tomography: A prospective study

      Background Initial biopsy of basal cell carcinoma (BCC) may fail to show aggressive histologic subtypes. Additionality, the clinical evaluation of BCC prior to surgery can miss subclinical extension. Reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) are emerging tools that can help in the presurgical evaluation of BCCs. Objective To assess the feasibility of a combined RCM-OCT imaging modality for presurgical evaluation of biopsy-proven BCCs for residual tumor, margins-status, and depth. Methods Thirty-eight BCCs in 35 patients referred to a tertiary cancer center for Mohs micrographic surgery (MMS) were imaged using combined RCM-OCT. Images were correlated to MMS-frozen-sections. Results ...

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    12. Optical coherence tomography of onychomycosis: proposed terminology and a suggestion of practical usage

      Optical coherence tomography of onychomycosis: proposed terminology and a suggestion of practical usage

      Onychomycosis is the most common cause of nail changes accounting for about half of all nail diseases. It is important to diagnose the fungal pathogen to prescribe adequate treatment, but as genus- and species-specific diagnostic tests can be time consuming and expensive, it is crucial to obtain representative tissue during nail scrapings. Optical coherence tomography (OCT) is a non-invasive imaging tool enabling real-time imaging of skin and tissue. Pilot studies using OCT have described morphological characteristics of onychomycosis, though diagnostic criteria of onychomycosis and other nail diseases are lacking. The aim of this study is to investigate the applicability of ...

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    13. Noninvasive Imaging Tools in Dermatology

      Noninvasive Imaging Tools in Dermatology

      The diagnosis of skin disease relies on visual inspection, often followed by biopsy and histopathologic examination, which remains the gold standard in diagnosis. New imaging tools, including dermoscopy, reflectance confocal microscopy (RCM), and optical coherence tomography (OCT), can provide noninvasive diagnoses while sparing unnecessary biopsies. We discuss dermoscopy, RCM, and OCT, and compare cost, clinical integration, reimbursement, and accuracy of these imaging modalities.

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    14. Monitoring the topical delivery of ultrasmall gold nanoparticles using optical coherence tomography

      Monitoring the topical delivery of ultrasmall gold nanoparticles using optical coherence tomography

      Background Optical coherence tomography (OCT) is a promising imaging modality for skin cancer diagnosis. However, this capability has been hindered by the low contrast between normal and neoplastic tissue. To overcome this limitation, gold nanoparticles have been used to enhance the contrast in OCT images and are topically administered to reduce the risk of systematic side effects associated with intravenous injection. To ensure efficient penetration and distribution of the nanoparticles, an enhanced delivery strategy is required. In this porcine study, we assessed two delivery methods: (a) using dimethyl sulfoxide (DMSO) and (b) via sonophoresis. Materials and Methods The gold nanoparticles ...

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    15. 2D Fourier Fractal Analysis of Optical Coherence Tomography Images of Basal Cell Carcinomas and Melanomas

      2D Fourier Fractal Analysis of Optical Coherence Tomography Images of Basal Cell Carcinomas and Melanomas

      The optical coherence tomography (OCT) technique is applied in the diagnosis of the skin tissue. In general, quantitative imaging features obtained from OCT images have already been used as biomarkers to categorize skin tumors. Particularly, the fractal dimension (FD) could be capable of providing an efficient approach for analyzing OCT images of skin tumors. The 2D Fourier fractal analysis (FFA) as well as the differential box counting method (DBCM) was used in this paper to classify the basal cell carcinomas (BCC), melanomas, and benign melanocytic nevi. Generalized estimating equations were used to test for differences between skin tumors. Our results ...

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    16. Comparison of optical coherence tomography and high frequency ultrasound imaging in mice for the assessment of skin morphology and intradermal volumes

      Comparison of optical coherence tomography and high frequency ultrasound imaging in mice for the assessment of skin morphology and intradermal volumes

      Optical coherence tomography (OCT) and high-frequency ultrasound (HFUS), two established imaging modalities in the field of dermatology, were evaluated and compared regarding their applicability for visualization of skin tissue morphology and quantification of murine intradermal structures. The accuracy and reproducibility of both methods were assessed ex vivo and in vivo using a standardized model for intradermal volumes based on injected soft tissue fillers. OCT revealed greater detail in skin morphology, allowing for detection of single layers due to the superior resolution. Volumetric data measured by OCT (7.9 ± 0.3 μl) and HFUS (7.7 ± 0.5 μl) were in ...

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    17. Nodular skin lesions: correlation of reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) features

      Nodular skin lesions: correlation of reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) features

      Nodular lesions have a common clinical appearance but very different prognostic implications. The differential diagnosis between malignant and benign nodular lesions is a challenge in everyday clinical practice. The malignant melanoma (MM) nodular variant expresses a vertical phase of growth and often has relatively high Breslow indexes 1,2 , so a timely correct diagnosis is crucial for correct lesion management. Conversely, non‐melanoma skin cancer (NMSC) rarely impacts on patient mortality and is most frequently observed in the form of a basal cell carcinoma (BCC), a locally aggressive, low‐grade neoplasia, prevalent among sun‐damaged elders 3,4 .

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    18. Separation of Overlapping Fingerprints in Multilayered Carrier Using Optical Coherence Tomography

      Separation of Overlapping Fingerprints in Multilayered Carrier Using Optical Coherence Tomography

      Fingerprints lifted from crime scenes are often overlapped because of multiple impressions of fingers. Current methods to separate overlapping fingerprints are primarily based on algorithms that estimate the orientation field of component prints. However, these methods need human intervention, and the accuracy of the separation may easily be degraded. In this paper, a novel tomographic imaging technique, optical coherence tomography (OCT), was used to separate overlapping fingerprints intuitively and noninvasively. The OCT system was also applied to reveal a hidden blood fingerprint that was completely covered by one layer of nontransparent paint. An additional experiment was conducted using a piece ...

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    19. Basal cell carcinoma treated with combined ablative fractional laser and ingenol mebutate – An exploratory study monitored by optical coherence tomography and reflectance confocal microscopy

      Basal cell carcinoma treated with combined ablative fractional laser and ingenol mebutate – An exploratory study monitored by optical coherence tomography and reflectance confocal microscopy

      Background Basal cell carcinomas (BCCs) have previously been treated off‐label with ingenol mebutate (IM). Ablative fractional laser (AFL) may improve efficacy of IM by increasing drug uptake in the tumor. Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) detect BCC non‐invasively. Our aim was to investigate BCC response and tolerability after combined AFL and IM treatment of low‐risk BCCs. Methods Twenty patients with histologically verified superficial (n=7) and nodular (n=13) BCCs were treated with combined fractional CO 2 ‐laser (10,600 nm) and IM 0.015% or 0.05%, the concentration depending on anatomical ...

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    20. Application of High Resolution Optical Coherence Tomography in Skin Disease: Amyloidosis and Differential Diagnosis

      Application of High Resolution Optical Coherence Tomography in Skin Disease: Amyloidosis and Differential Diagnosis

      Amyloidosis is caused by the misfolding protein accumulated in tissue, which affects the function of the organs. In addition to the primary cutaneous amyloidosis, a skin lesion may also appear in another classification - systemic amyloidosis. Physicians can confirm diagnosis of the above classification by skin biopsy. Primary cutaneous amyloidosis is common in Asia and South America. In Taiwan, 80 people are diagnosed with primary cutaneous amyloidosis in every 100,000 people. Among the disease, macular amyloidosis and lichen amyloidosis are the most common subtypes. Primary cutaneous amyloidosis can cause severe itching, pigmentation, and skin keratosis, and further affect the social ...

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    21. Early Feasibility Study: Application of OCT Imaging in Dermatology

      Early Feasibility Study: Application of OCT Imaging in Dermatology

      Optical coherence tomography (OCT) is an established medical imaging technique that uses light to capture biological images from within optical scattering media (e.g., biological tissue). A high-resolution OCT has the characteristics of non-invasive, label-free, real-time, cellular resolution with high tissue penetration depth that are highly valuable for clinical use. Apollo Medical Optics, Ltd. (AMO)'s product originated at National Taiwan University (NTU), when AMO's researchers first began investigating medical optics. Apollo Medical Optics has developed a platform-based OCT tissue scanning system (B100) and have been conducting studies at the Mackay Memorial Hospital, Taipei as well as the Memorial ...

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    1-24 of 891 1 2 3 4 ... 36 37 38 »
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