1. Articles in category: Dermatology

    1-24 of 867 1 2 3 4 ... 35 36 37 »
    1. Skin evaluation method and skin evaluation device

      Skin evaluation method and skin evaluation device

      A profile of optical reflectance relative to a depth within a depth range from an epidermis to an upper layer of a dermis is created based on a coherence signal obtained by optical coherence tomography, an evaluation index is determined by calculating a difference between reflectance at a local minimum point and reflectance at a second local maximum point from the created profile, and skin conditions are evaluated based on the evaluation index.

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    2. Smart bandages fitted with microsensors could soon be used to make sure wounds are healing properly

      Smart bandages fitted with microsensors could soon be used to make sure wounds are healing properly

      sensor is being developed which could one day be embedded in bandages to ensure wounds are healing as planned. Engineers from Heriot-Watt University in Edinburgh are working on a project to create a micro sensor capable of detecting tiny fluctuations in the repair process. Microscale mechanical changes will be observed and tracked to allow for better healing, the researchers hope. It is estimated wounds cost the NHS up to £5.1 billion a year with resources used on burns, diabetic ulcers, caesarean section scars, surgical incisions and simple cuts. Scroll down for video Grazes, such as this one obtained whilst ...

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    3. Dermoscopy, Optical Coherence Tomography, and Histological Correlation of Pseudoxanthoma Elasticum

      Dermoscopy, Optical Coherence Tomography, and Histological Correlation of Pseudoxanthoma Elasticum

      We propose the case of a 17-year-old female patient with multiple, soft, yellowish papules symmetrically distributed on the neck ( Figure 1A ). Dermoscopy showed a yellowish orange area associated with reddish and whitish areas [ 1 ] ( Figure 1B ). Optical coherence tomography (OCT) revealed normal epidermis associated with clusters of horizontally oriented dermal aggregates with peripheral clefts ( Figure 1C ). A biopsy was performed in the same site of previous noninvasive imaging techniques. Histology disclosed the presence of altered elastic fibers in the upper and reticular dermis with extension to the papillary dermis stained with hematoxylin and eosin ( Figure 1D ). Pseudoxanthoma elasticum (PXE) is ...

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    4. OCT in the diagnosis of head and neck pre-cancerous and cancerous cutaneous lesions: An immediate ex vivo study

      OCT in the diagnosis of head and neck pre-cancerous and cancerous cutaneous lesions: An immediate ex vivo study

      Background Optical coherence tomography (OCT) has been shown to reliably identify skin changes with the combined advantage of resolution and penetration depth. The objective of this study was to assess the accuracy of OCT in diagnosing various skin pathologies, using pre-set diagnostic criteria, by two reviewers blinded to the actual diagnosis. Material and methods This immediate ex-vivo study included skin specimens from 103 patients with suspicious skin lesions. In total, 110 lesions were scanned using OCT immediately following surgical resection. Two experienced OCT reviewers assessed these OCT diagnostic parameters blindly at two different intervals based on the parameters of the ...

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    5. First Use of Optical Coherence Tomography on In Vivo Inflammatory Acne‐Like Lesions: A Murine Model

      First Use of Optical Coherence Tomography on In Vivo Inflammatory Acne‐Like Lesions: A Murine Model

      Background and Objectives Successful outcomes of clinical studies for acne vulgaris depend greatly on achieving statistically significant reduction in acne lesion count and improvement in Investigator's Global Assessment score of the investigational drug product against its vehicle control. To date, there has not been a validated preclinical acne model to evaluate investigational drug products in order to improve the probability of clinical success. An inflammatory acne‐like lesion mouse model developed in‐house has previously been used for clinical guidance in our drug development program. In this study, we aim to implement and assess the adequacy of swept‐source ...

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    6. Physical Sciences Inc Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

      Physical Sciences Inc Receives NIH Grant for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance

      Physical Sciences Inc Receives a 2019 NIH Grant for $300,000 for Multimodal Optical Probe for Skin Cancer Detection and Therapy Guidance. The principal investigator is Nicusor Iftimia. The program began in 2019 and ends in 2020. Below is a summary of the proposed work. The primary goal of this research project is to develop and translate to clinical use a novel optical imaging technology based on combined Optical Coherence Tomography (OCT) and Confocal Microscopy (CM) for non- invasive real-time diagnosis of non-melanoma skin cancers (NMSCs), tumor subtyping and margin mapping that will assist physician-patient decision in treatment planning (biopsy ...

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    7. Use of Vibrational Optical Coherence Tomography to Characterize Skin Lesions and a Congenital Nevus

      Use of Vibrational Optical Coherence Tomography to Characterize Skin Lesions and a Congenital Nevus

      We have used vibrational optical coherence tomography (VOCT) to image and measure the mechanical properties of normal skin and skin lesions. It is observed that in a congenital nevus and normal skin, the cellular epidermis is qualitatively not as bright as in skin lesions including basal cell carcinoma, actinic keratosis and a melanocytic nevus. Melanin and cytochrome c oxidase are reported to attenuate the reflection of near-infrared light at a wavelength of 810 nm and therefore may explain the reduced reflection of light in a congenital nevus and normal skin under conditions where cytochrome c oxidase levels would be expected ...

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    8. Successful Treatment of Genital Warts with Ingenol Mebutate Monitored with Optical Coherence Tomography and Reflectance Confocal Microscopy

      Successful Treatment of Genital Warts with Ingenol Mebutate Monitored with Optical Coherence Tomography and Reflectance Confocal Microscopy

      Ingenol mebutate (IM) is approved for the treatment of actinic keratosis and induces cell death in precancerous lesions. The efficacy of IM in the treatment of genital warts was investigated in a therapy-refractory patient. The 74-year-old male was treated with IM gel for three consecutive days. Treatment course and efficacy were evaluated by clinical inspection and non-invasive diagnostics namely optical coherence tomography (OCT) and reflectance confocal microscopy (RCM). Within 24 to 48 hours IM induced a strong local inflammatory reaction. One week later a complete response was observed. OCT and RCM showed a strong reaction after treatment with erosions, swelling ...

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    9. The Impact of First‐Aid Dressing Design on Healing of Porcine Partial Thickness Wounds

      The Impact of First‐Aid Dressing Design on Healing of Porcine Partial Thickness Wounds

      Literature describes that a well‐maintained moist wound healing environment leads to faster healing by preventing scabbing and drying of the wound. A moist wound speeds healing by allowing for unimpeded movement of newly dividing epidermal cells in the wound. Contrary to what is described in literature and practiced by clinicians, first‐aid dressings used at home by consumers advertise breathability and absorptivity as benefits. This manuscript examines the effects of dressing breathability and highly absorptive pads on healing and wound appearance in a porcine dermatome wound model, designed to mimic an abrasion injury. Partial thickness wounds were covered with ...

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    10. En-face optical coherence tomography/fluorescence endomicroscopy for minimally invasive imaging using a robotic scanner

      En-face optical coherence tomography/fluorescence endomicroscopy for minimally invasive imaging using a robotic scanner

      We report a compact rigid instrument capable of delivering en-face optical coherence tomography (OCT) images alongside (epi)-fluorescence endomicroscopy (FEM) images by means of a robotic scanning device. Two working imaging channels are included: one for a one-dimensional scanning, forward-viewing OCT probe and another for a fiber bundle used for the FEM system. The robotic scanning system provides the second axis of scanning for the OCT channel while allowing the field of view (FoV) of the FEM channel to be increased by mosaicking. The OCT channel has resolutions of 25  /  60  μm (axial/lateral) and can provide en-face images with ...

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    11. Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks

      Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks

      Optical coherence tomography (OCT) enables the non-invasive acquisition of high-resolution three-dimensional cross-sectional images at micrometer scale and is mainly used in the field of ophthalmology for diagnosis as well as monitoring of eye diseases. Also in other areas, such as dermatology, OCT is already well established. Due to its non-invasive nature, OCT is also employed for research studies involving animal models. Manual evaluation of OCT images of animal models is a challenging task due to the lack of imaging standards and the varying anatomy between models. In this paper, we present a deep learning algorithm for the automatic segmentation of ...

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    12. Subsurface and Layer Intertwined Template Protection Using Inherent Properties of Full-Field Optical Coherence Tomography Fingerprint Imaging

      Subsurface and Layer Intertwined Template Protection Using Inherent Properties of Full-Field Optical Coherence Tomography Fingerprint Imaging

      The emergence of Full Field-Optical Coherence Tomography (FF-OCT) for fingerprint imaging has shown it’s ability in addressing and solving the drawbacks of traditional fingerprinting solutions such as spoofing attacks, low accuracy for abraded fingerprint. With the availability of multiple internal fingerprints (from subsurface captured at different depths), it is also essential to consider the aspects of ideal biometrics where the privacy of the fingerprint data is preserved. In this work, we propose a new framework for fingerprint template protection, highly customized to FF-OCT by exploring the interplay between subsurface. As a first of it’s kind work attempting template ...

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    13. New Hope for Port Wine Stain Patients from A Novel Image-Guided Treatment

      New Hope for Port Wine Stain Patients from A Novel Image-Guided Treatment

      Michelson Diagnostics Ltd. (MDL) announces increased outcome benefits from a powerful new treatment approach for patients with Port Wine Stain birthmarks and other disfiguring conditions of the superficial blood vessels in skin, such as hemangiomas, rosacea and spider veins. The novel technique, known as OCT image-guided treatment, utilizes a high-resolution laser scanner to detect and image the tiny blood vessels in the skin, so that the depth, diameter and density of these vessels can be accurately characterized. This information is crucial for optimizing the settings for laser or Broadband Light (BBL) treatments, so that diseased and abnormal vessels are destroyed ...

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    14. Rutgers Scientist Creates “Virtual Biopsy” Device to Detect Skin Tumors

      Rutgers Scientist Creates “Virtual Biopsy” Device to Detect Skin Tumors

      Using sound vibrations and pulses of near-infrared light, a Rutgers University scientist has developed a new “virtual biopsy” device that can quickly determine a skin lesion’s depth and potential malignancy without using a scalpel. The ability to analyze a skin tumor non-invasively could make biopsies much less risky and distressing to patients, according to a report in Wiley Online Library. Currently, physicians who perform surgical biopsies often don’t know the extent of a lesion – and whether it will be necessary to refer the patient to a specialist for extensive tissue removal or plastic surgery – until surgery has already ...

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      Mentions: FDA
    15. Comparative “virtual biopsies” of normal skin and skin lesions using vibrational optical coherence tomography

      Comparative “virtual biopsies” of normal skin and skin lesions using vibrational optical coherence tomography

      Background Increased tissue stiffness (also termed modulus) has been shown to be a characteristic of potential tumor metastasis. Measured values of the stiffness of tumors and cancer cells are reported in the literature to increase compared to neighboring normal tissues. Yet the relationship between the mechanical properties of cells and the extracellular matrix has yet to be correlated with the histopathology of cancerous lesions. Materials and Methods We have developed a technique to do virtual biopsies of skin lesions by combining images made using optical coherence tomography with stiffness measurements made simultaneously using vibrational analysis. The technique is termed vibrational ...

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      Mentions: OptoVibronex
    16. Optical coherence tomography correlates multiple measures of tissue damage following acute burn injury

      Optical coherence tomography correlates multiple measures of tissue damage following acute burn injury

      Background: The visual assessment of burned skin is inherently subjective, and whilst a number of imaging modalities have identified quantifiable parameters to characterize vascular and structural changes following burn damage, none have become common place in the assessment protocol. Here, we use optical coherence tomography (OCT)-based angiography (OCTA) to introduce novel correlations between vessel depth, i.e., the depth of functional blood vessels beneath the tissue surface, edema depth, i.e., the depth of interstitial fluid buildup beneath the tissue surface, and tissue injury depth, i.e., the depth of collagen denaturation beneath the tissue surface, following burn injury ...

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    17. Quantitative assessment of skin swelling using optical coherence tomography

      Quantitative assessment of skin swelling using optical coherence tomography

      Background Preclinical and clinical studies suggest that optical coherence tomography (OCT) is a useful tool to visualize inflammatory conditions. Objective The objective of this study was to evaluate the usefulness of combining OCT and various image processing techniques for quantitative assessment of histamine-induced tissue swelling. Methods Both time-domain and frequency-domain OCT were used on a mouse ear model. The ear thickness and volume before and after histamine challenge were determined from pixel locations in 2D scans and voxel number counting in 3D scans. Swelling kinetics was analyzed on 3D contour mapping. Microvessel network was visualized using speckle decorrelation analysis. Results ...

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    18. Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography

      Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography

      Optical coherence tomography angiography (OCTA) provides in-vivo images of microvascular perfusion in high resolution. For its application to basic and clinical research, an automatic and robust quantification of the capillary architecture is mandatory. Only this makes it possible to reliably analyze large amounts of image data, to establish biomarkers, and to monitor disease developments. However, due to its optical properties, OCTA images of skin often suffer from a poor signal-to-noise ratio and contain imaging artifacts. Previous work on automatic vessel segmentation in OCTA mostly focuses on retinal and cerebral vasculature. Its applicability to skin and, furthermore, its robustness against imaging ...

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    19. The evolution of healthy skin to acne lesions: a longitudinal, in vivo evaluation with reflectance confocal microscopy and optical coherence tomography

      The evolution of healthy skin to acne lesions: a longitudinal, in vivo evaluation with reflectance confocal microscopy and optical coherence tomography

      Background Comedogenesis is defined as the process of the development of a new comedo, which is of great importance for the understanding of acne. Objective To evaluate the formation and evolution of acne lesions from clinically unaffected skin of patients with mild‐moderate acne to characterize the morphological changes and natural resolution by means of in vivo reflectance confocal microscopy (RCM) and dynamic otpical coherence tomography (D‐OCT). Methods ten patients with mild‐moderate acne, not assuming any topical or systemic therapy, comprised between 12 and 30 years of age, were recruited. A target area of 4x4mm of the face ...

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    20. Optical Coherence Tomography in Evaluation of Glomus Tumors: A Report of Three Cases

      Optical Coherence Tomography in Evaluation of Glomus Tumors: A Report of Three Cases

      Glomus tumors are painful, benign perivascular neoplasms of the glomus body affecting the nail apparatus. Although diagnosis can be made clinically using Love's and Hildreth's tests, imaging is required to distinguish glomus tumors from other subungual vascular lesions. Clinical diagnosis is complicated when the nail has no visible abnormalities. 1 Magnetic resonance imaging (MRI) is the modality of choice for imaging but requires a dedicated small part coil, which is unavailable at some facilities and is costly. 2

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    21. High-accurate and robust fingerprint anti-spoofing system using Optical Coherence Tomography

      High-accurate and robust fingerprint anti-spoofing system using Optical Coherence Tomography

      Traditional commercial automated fingerprint recognition systems (AFRSs) are vulnerable to fake attacks by the use of artificial fingerprints, due to its limitation on resolution and the difficulty of obtaining depth information. Developing new systems with strong anti-spoofing ability are of increasing concern in the current digital age. Inspired by the observation and comparison of fingertip skin structure and the one dimensional (1D) depth signals derived from OCT acquisition images between real finger and artificial fingerprints, two novel anti-spoofing features, namely depth-double-peak feature and sub-single-peak feature, were specifically defined. Depth-double-peak feature refers that there must be two and only two peaks ...

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    1-24 of 867 1 2 3 4 ... 35 36 37 »
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