1. Articles in category: Dermatology

    1-24 of 550 1 2 3 4 ... 21 22 23 »
    1. Optical Coherence Tomography Imaging of Normal, Chronologically Aged, Photoaged and Photodamaged Skin: A Systematic Review

      Optical Coherence Tomography Imaging of Normal, Chronologically Aged, Photoaged and Photodamaged Skin: A Systematic Review

      BACKGROUND: Optical coherence tomography (OCT) is capable of providing a noninvasive real-time cross-sectional image of the skin through light-based interferometry, a method sometimes described as "light-based ultrasound." One key application of OCT in dermatology is the visualization of dermal collagen during chronological aging, photoaging, or photodamage. These skin conditions are typically managed by the practitioner's subjective assessment of severity and response to therapy. OBJECTIVE: The purpose of this review is to present available evidence on the ability of OCT to image normal, chronologically aged, photoaged and photodamaged skin in human subjects. METHODS AND MATERIALS: The authors have searched Medline ...

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    2. Medical images classication for skin cancer using quantitative image features with optical coherence tomography

      Medical images classication for skin cancer using quantitative image features with optical coherence tomography

      Optical coherence tomography (OCT) is employed in the diagnosis of skin cancer. Particularly, quantitative image features extracted from OCT images might be used as indicators to classify the skin tumors. In the present paper, we investigated intensity-based, texture-based and fractal-based features for automatically classifying the melanomas, basal cell carcinomas and pigment nevi. Generalized estimating equations were used to test for differences between the skin tumors. A modified p value of < 0.001 was considered statistically significant. Significant increase of mean and median of intensity and significant decrease of mean and median of absolute gradient were observed in basal cell carcinomas ...

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    3. In vivo dual-modality photoacoustic and optical coherence tomography imaging of human dermatological pathologies

      In vivo dual-modality photoacoustic and optical coherence tomography imaging of human dermatological pathologies

      Vascular abnormalities serve as a key indicator for many skin diseases. Currently available methods in dermatology such as histopathology and dermatoscopy analyze underlying vasculature in human skin but are either invasive, time-consuming, and laborious or incapable of providing 3D images. In this work, we applied for the first time dual-modality photoacoustic and optical coherence tomography that provides complementary information about tissue morphology and vasculature of patients with different types of dermatitis. Its noninvasiveness and relatively short imaging time and the wide range of diseases that it can detect prove the merits of the dual-modality imaging system and show the great ...

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    4. Development of ultraviolet- and visible-light one-shot spectral domain optical coherence tomography and in situ measurements of human skin

      Development of ultraviolet- and visible-light one-shot spectral domain optical coherence tomography and in situ measurements of human skin

      We have developed ultraviolet (UV)- and visible-light one-shot spectral domain (SD) optical coherence tomography (OCT) that enables in situ imaging of human skin with an arbitrary wavelength in the UV–visible-light region (370–800 nm). We alleviated the computational burden for each color OCT image by physically dispersing the irradiating light with a color filter. The system consists of SD-OCT with multicylindrical lenses; thus, mechanical scanning of the mirror or stage is unnecessary to obtain an OCT image. Therefore, only a few dozens of milliseconds are necessary to obtain single-image data. We acquired OCT images of one subject’s skin ...

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    5. Systematic review of optical coherence tomography usage in the diagnosis and management of basal cell carcinoma - Cheng - British Journal of Dermatology

      Systematic review of optical coherence tomography usage in the diagnosis and management of basal cell carcinoma - Cheng - British Journal of Dermatology

      Optical coherence tomography (OCT) is a non-invasive imaging tool used in-vivo, in real time for diagnosis, treatment delineation and monitoring of basal cell carcinomas (BCC) treatment. Features of BCC on OCT have been widely described and reviewed. However, the diagnostic accuracy of OCT in these various applications are unclear. We systematically reviewed the literature to assess the accuracy of OCT in diagnosis and management of BCC using the Embase and Medline databases. 179 unique references were identified in the initial search. 22 studies with 556 histologically-proven BCC were eligible. Assessment of quality of eligible studies was undertaken using the STROBE ...

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    6. Directional, passive liquid transport: the Texas horned lizard as a model for a biomimetic ‘liquid diode’

      Directional, passive liquid transport: the Texas horned lizard as a model for a biomimetic ‘liquid diode’

      Moisture-harvesting lizards such as the Texas horned lizard (Iguanidae: Phrynosoma cornutum ) live in arid regions. Special skin adaptations enable them to access water sources such as moist sand and dew: their skin is capable of collecting and transporting water directionally by means of a capillary system between the scales. This fluid transport is passive, i.e. requires no external energy, and directs water preferentially towards the lizard's snout. We show that this phenomenon is based on geometric principles, namely on a periodic pattern of interconnected half-open capillary channels that narrow and widen. Following a biomimetic approach, we used these ...

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    7. Recent advances in clinical application of optical coherence tomography of human skin

      Recent advances in clinical application of optical coherence tomography of human skin

      Optical coherence tomography (OCT) is an emerging noninvasive imaging method that uses infrared light and interferometric techniques. The method has become increasingly popular in skin research as well as daily dermatology practice. In the present brief review, we focused on recent (2009–2014) OCT studies on the human skin, which included a reasonable sample size and statistics. Twenty-five papers were selected and briefly described OCT of epidermal thickness, skin appendages, wound healing, extracellular matrix and skin fibrosis, vascular malformations, and skin tumors such as basal cell carcinoma, actinic keratoses, and malignant melanoma

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      Mentions: Thilo Gambichler
    8. Update on non-invasive imaging techniques in early diagnosis of non-melanoma skin cancer

      Update on non-invasive imaging techniques in early diagnosis of non-melanoma skin cancer

      BACKGROUND: Non-melanoma skin cancer (NMSC) is the most common malignancy in fair skinned populations. Dermoscopy, reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) are non-invasive imaging techniques that play an important role in diagnosis of skin tumors. AIM: To provide new insights into the role of non-invasive tecniques in the diagnosis of non melanoma skin cancers, concentrating especially on dermoscopy, RCM and OCT. METHODS: The analysis of the studies obtained from the most recent literature, taking into account previous essential reported information in this field. A search concerning the role of dermoscopy, RCM and OCT in the diagnosis of ...

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    9. Speckle reduction process based on digital filtering and wavelet compounding in optical coherence tomography for dermatology

      Speckle reduction process based on digital filtering and wavelet compounding in optical coherence tomography for dermatology

      Optical Coherence Tomography (OCT) has shown a great potential as a complementary imaging tool in the diagnosis of skin diseases. Speckle noise is the most prominent artifact present in OCT images and could limit the interpretation and detection capabilities. In this work we propose a new speckle reduction process and compare it with various denoising filters with high edge-preserving potential, using several sets of dermatological OCT B-scans. To validate the performance we used a custom-designed spectral domain OCT and two different data set groups. The first group consisted in five datasets of a single B-scan captured N times (with N ...

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    10. Optical coherence tomography (OCT) features of nevi and melanomas and their association with intraepidermal or dermal involvement: A pilot study

      Optical coherence tomography (OCT) features of nevi and melanomas and their association with intraepidermal or dermal involvement: A pilot study

      To the Editor: Optical coherence tomography (OCT) was shown to be an useful tool for the fast evaluation of nonmelanocytic tumors of the skin. 1 There are few reports in the literature studying melanocytic lesions with OCT, with variable and sometimes contrasting results. 2 , 3 A constant need for reducing costs and cosmetic concerns of unnecessary excisions of suspicious melanocytic lesions lead us to further investigate this new technology. 4 We used OCT (Vivosight OCT Scanner, Michelson Diagnostics Ltd, Orpington, Kent, United Kingdom) to evaluate a total of 39 lesions: 19 melanomas (10 in situ and 9 invasive, with Breslow ...

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    11. Optical coherence tomography in dermatology

      Optical coherence tomography in dermatology

      BACKGROUND: Optical coherence tomography (OCT) was first used in skin imaging in 1997, and since then the technology has undergone significant technological development. With its high resolution and moderate penetration depth OCT fills the imaging gap between High Frequency Ultrasound and Reflectance Confocal Microscopy. Different modalities of OCT have been developed either focusing on higher image resolution or special visualization of tissue with distinct optical properties, including collagen and blood flow. AIM: The aim of this study is to describe trends in OCT research on different dermatological diseases and review the results. METHODS: Pubmed, EMBASE, Web of science, Google Scholar ...

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    12. Full-field swept-source optical coherence tomography with phase-shifting techniques for skin cancer detection

      Full-field swept-source optical coherence tomography with phase-shifting techniques for skin cancer detection

      The EU-funded project VIAMOS1 proposes an optical coherence tomography system (OCT) for skin cancer detection, which combines full-field and full-range swept-source OCT in a multi-channel sensor for parallel detection. One of the project objectives is the development of new fabrication technologies for micro-optics, which makes it compatible to Micro-Opto-Electromechanical System technology (MOEMS). The basic system concept is a wafer-based Mirau interferometer array with an actuated reference mirror, which enables phase shifted interferogram detection and therefore reconstruction of the complex phase information, resulting in a higher measurement range with reduced image artifacts. This paper presents an experimental one-channel on-bench OCT system ...

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    13. In vivo visualization of skin inflammation by optical coherence tomography and two-photon microscopy

      In vivo visualization of skin inflammation by optical coherence tomography and two-photon microscopy

      Inflammation is a non-specific immune response to injury intended to protect biological tissue from harmful stimuli such as pathogens, irritants, and damaged cells. In vivo optical tissue imaging has been used to provide spatial and dynamic characteristics of inflammation within the tissue. In this paper, we report in vivo visualization of inflammation in the skin at both cellular and physiological levels by using a combination of label-free two-photon microscopy (TPM) and optical coherence tomography (OCT). Skin inflammation was induced by topically applying lipopolysaccharide (LPS) on the mouse ear. Temporal OCT imaging visualized tissue swelling, vasodilation, and increased capillary density 30 ...

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      Mentions: Ki Hean Kim
    14. A novel imaging approach to periocular basal cell carcinoma: in vivo optical coherence tomography and histological correlates

      A novel imaging approach to periocular basal cell carcinoma: in vivo optical coherence tomography and histological correlates

      Purpose Optical coherence tomography (OCT) is a non-invasive imaging method widely used in ophthalmology. Recent developments have produced OCT devices for imaging the skin. The purpose of this study was to investigate Fourier Domain OCT morphological features of periocular basal cell carcinoma (BCC) in correlation with conventional histopathology. Methods Consecutive patients with periocular nodular BCC were prospectively examined with VivoSight OCT (Michelson Ltd) prior to surgical excision. OCT slice mode images were analysed using criteria defined for conventional and HD-OCT; the images were correlated to haematoxylin and eosin stained histology sections. Results A total of 15 patients with periocular BCC ...

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    15. Correlation between polarization sensitive optical coherence tomography and second harmonic generation microscopy in skin

      Correlation between polarization sensitive optical coherence tomography and second harmonic generation microscopy in skin

      Both polarization sensitive optical coherence tomography (PS-OCT) and second harmonic generation (SHG) microscopy are 3D optical imaging methods providing information related to collagen in the skin. PS-OCT provides birefringence information which is due to the collagen composition of the skin. SHG microscopy visualizes collagen fibers in the skin based on their SHG property. These two modalities have been applied to the same skin pathologies associated with collagen changes, but their relationship has not been examined. In this study, we tried to find the relationship by imaging the same skin samples with both modalities. Various parts of the normal rat skin ...

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      Mentions: Ki Hean Kim
    16. High-definition optical coherence tomography intrinsic skin ageing assessment in women: a pilot study

      High-definition optical coherence tomography intrinsic skin ageing assessment in women: a pilot study

      Several non-invasive two-dimensional techniques with different lateral resolution and measurable depth range have proved to be useful in assessing and quantifying morphological changes in skin ageing. Among these, only in vivo microscopy techniques permit histometric measurements in vivo. Qualitative and quantitative assessment of chronological (intrinsic) age-related (IAR) morphological changes of epidermis, dermo-epidermal junction (DEJ), papillary dermis (PD), papillary-reticular dermis junction and reticular dermis (RD) have been performed by high-definition optical coherence tomography in real time 3-D. HD-OCT images were taken at the internal site of the right upper arm. Qualitative HD-OCT IAR descriptors were reported at skin surface, at epidermal ...

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    17. Transformative clinical results with VivoSight in the diagnosis of Basal Cell Carcinoma: Data to be presented at the World Congress of Dermatology in Vancouver

      Transformative clinical results with VivoSight in the diagnosis of Basal Cell Carcinoma: Data to be presented at the World Congress of Dermatology in Vancouver

      Michelson Diagnostics, a medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces that data showing significant improvement in the diagnosis of basal-cell carcinoma (BCC) using its VivoSight multibeam OCT scanner will be presented at the World Congress of Dermatology (Vancouver, June 8-13). In addition to being an efficient, non-invasive way to diagnose BCC and other non-melanoma skin cancers, using the VivoSight OCT scanner has the potential to reduce biopsies and surgery, thereby reducing scarring for patients. Joint lead investigator, Dr Martina Ulrich, CMB Collegium, Berlin, Germany, will outline the results of this independent multi-centre, prospective clinical ...

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    18. Skin substitute-assisted repair shows reduced dermal fibrosis in acute human wounds validated simultaneously by histology and optical coherence tomography

      Skin substitute-assisted repair shows reduced dermal fibrosis in acute human wounds validated simultaneously by histology and optical coherence tomography

      Skin substitutes are heterogeneous biomaterials designed to accelerate wound healing through provision of replacement extracellular matrix. Despite growing evidence for their use in chronic wounds, the role of skin substitutes in acute wound management and their influence upon fibrogenesis remains unclear. Skin substitute characteristics including biocompatibility, porosity and elasticity strongly influence cellular behaviour during wound healing. Thus, we hypothesise that structural and biomechanical variation between biomaterials may induce differential scar formation after cutaneous injury. The following human prospective cohort study was designed to investigate this premise. Four 5mm full-thickness punch biopsies were harvested from fifty volunteers. In all cases, site ...

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    19. Cambridge role in new medical device

      Cambridge role in new medical device

      VivoSight Dx is aimed at dermatologists seeking an imaging system that will enhance their ability to make rapid and accurate diagnostic decisions for their patients. Michelson Diagnostics approached eg technology to undertake the aesthetic and detailed design of the product trolley and enclosure and the assembly methodology of the functional elements of the OCT system. eg and Michelson worked with dermatologists who were already using the first generation OCT system in order to gain insight into how the machine was used and how the system could be developed to enhance the experience of both the user and the patient. From ...

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    20. Diagnostic Device For Dermatology With Merged Oct And Epiluminescence Dermoscopy

      Diagnostic Device For Dermatology With Merged Oct And Epiluminescence Dermoscopy

      Systems and methods for use of the imaging system are presented. In an embodiment, the imaging system includes a first optical path, a second optical path, a plurality of optical elements, a detector, and a processor. The first optical path guides a first beam of radiation associated with epiluminescence while the second optical path guides a second beam of radiation associated with optical coherence tomography.

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    21. Michelson Diagnostics launches next generation OCT System – VivoSight Dx

      Michelson Diagnostics launches next generation OCT System – VivoSight Dx

      Michelson Diagnostics, the UK based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces the launch of VivoSight Dx, the Company’s second generation OCT system, at the German Society of Dermatology 48 th Congress 2015 (DDG 2015), 29 th April – 2 nd May 2015, Berlin. VivoSight Dx is aimed at dermatologists seeking an imaging system that will enhance their ability to make rapid, accurate diagnostic decisions for their patients. It is lighter, more compact and more mobile than the first generation OCT system, enabling its use in a consulting room at short notice. VivoSight Dx ...

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    22. Landmark VivoSight OCT clinical study published in British Journal of Dermatology

      Landmark VivoSight OCT clinical study published in British Journal of Dermatology

      Results demonstrate clinical value of OCT in basal cell carcinoma diagnosis Michelson Diagnostics, the UK-based medical device company focused on multi-beam Optical Coherence Tomography (‘OCT’) technology, today announces the publication on-line in the British Journal of Dermatology of the full results from an independent clinical study that demonstrates for the first time the clinical value of OCT in the diagnosis of basal cell carcinoma (BCC) 1 . This observational, prospective, multi-centre study was conducted using the Company’s VivoSight multi-beam OCT device. This study highlights that using VivoSight OCT is an efficient, non-invasive way to diagnose BCC and has the potential ...

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