Student Theses -Optical Coherence Tomography News

Articles in category: Student Theses

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1. Characterization Of The Macular Choriocapillaris In Dry Age-Related Macular Degeneration Using Swept-Source Optical Coherence Tomography Angiography (Thesis)
  
  Explore elischolar.library.yale.edu Dec 24 2020 Ophthalmology , Student Theses
  
  The purpose of this study was to characterize further, using swept-source (SS-) optical coherence tomography angiography (OCTA), the relationship between dry age-related macular degeneration (AMD) and the macular choriocapillaris (CC), which may have pathophysiologic and therapeutic implications. It included (1) a topographic analysis to determine if there is a significant relationship between dry AMD stage and macular CC perfusion, and (2) an investigation of the predictive value of macular CC perfusion with respect to geographic atrophy (GA) growth rate. Study design was retrospective and cross-sectional. A database of 6x6 mm fovea-centered swept-source OCTA images of the CC from eyes with ...
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  Mentions: Yale University
2. High-speed Time-stretch Optical Coherence Tomography (Thesis)
  
  Explore DTU Research Database Dec 14 2020 Broadband Sources , Student Theses
  
  Supercontinuum sources have great potential in optical coherence tomography due to their ultrabroad spectra, which provide ultrahigh resolution images. High intensity noise of conventional supercontinuum sources, however, has been the limiting factor of widespread adoption, but the emergence of low noise supercontinuum sources promise to change this. In this thesis, both types of supercontinuum sources are tested in a spectrometer-based optical coherence tomography setup, where it is found that the low noise supercontinuum is able to produce the shot noise limited images, a feat that is not replicated by the conventional supercontinuum. Furthermore, the two types of supercontinuum sources are ...
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  Mentions: Technical University of Denmark (DTU)
3. Development of High-Sensitivity and High-resolution Optical Coherence Tomography (Thesis)
  
  Explore Lehigh Preserve Oct 4 2020 Student Theses
  
  Optical coherence tomography (OCT) is a rapid-developing biomedical imaging tool that can achieve micro-level resolution, high speed, non-destructive three-dimensional images. A variety of clinical applications in humans employs OCT, including ophthalmolo
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  Mentions: Lehigh University
4. Image-guidance in ophthalmic surgery using optical coherence tomography (Thesis)
  
  Explore Institutional Repository Home Aug 24 2020 Ophthalmology , Student Theses
  
  Ophthalmic surgery involves manipulation of layered tissue structures on milli- to micrometer scales. Traditional surgical microscopes provide a two-dimensional view of the surgical field with limited depth perception which precludes accurate depth-resolved visualization of surgically-induced tissue morphology. Optical coherence tomography (OCT) enables non-contact exogenous contrast-free imaging of subsurface tissue microstructures, and is currently the gold standard for ophthalmic clinical diagnostics. Over the last decade, translation of OCT technologies to applications in surgical planning and guidance in ophthalmology has been an active area of research and commercialization. Clinical studies confirmed benefits of intraoperative OCT including verification that surgical goals have been ...
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  Mentions: Vanderbilt University
5. Studying Cerebral Blood Flow in Mouse Cortex with Optical Microangiography (Thesis)
  
  Explore digital.lib.washington.edu Aug 20 2020 Student Theses
  
  Optical coherence tomography (OCT) is a non-contact three-dimensional (3D) imaging modality which enables fast in vivo volumetric visualization of internal structures of biological tissues with high resolution. In this thesis, first, the application of OCT advanced extension - optical microangiography (OMAG) - was used to reveal the temporal profile of hemodynamic response to neural activation and the variation of depth-resolved blood flow changes in mouse cerebral cortex. The results showed that the largest hemodynamic response occurred in cortical layer IV. Second, OMAG and Doppler OMAG (DOMAG) techniques were applied to quantitatively evaluate the anesthesia effect on cerebral vessel morphology and blood flow ...
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6. Traction force optical coherence microscopy: a new method to study the dynamic mechanical behavior of cells and multicellular collectives within scattering media (Thesis)
  
  Explore Home Aug 17 2020 Student Theses
  
  Mechanobiology is a prominent research field which seeks to elucidate the role of physical forces and mechanical interactions throughout various biological processes, including morphogenesis, wound healing, and cancer metastasis, among others. Traction force microscopy (TFM) is an important family of experimental techniques used by mechanobiologists to study and quantify the forces that cells exert upon their surroundings. Recent years have seen a growing demand for TFM methods capable of studying the dynamic, 3D, and collective behaviors of cells embedded within optically scattering media. However, traditional imaging modalities for TFM (e.g., confocal microscopy) do not currently allow researchers to satisfy ...
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  Mentions: Cornell University
7. Deep learning for quantitative motion tracking based on optical coherence tomography (Thesis)
  
  Explore digitalcommons.njit.edu Aug 17 2020 Student Theses
  
  Optical coherence tomography (OCT) is a cross-sectional imaging modality based on low coherence light interferometry. OCT has been widely used in diagnostic ophthalmology and has found applications in other biomedical fields such as cancer detection and surgical guidance. In the Laboratory of Biophotonics Imaging and Sensing at New Jersey Institute of Technology, we developed a unique needle OCT imager based on a single fiber probe for breast cancer imaging. The needle OCT imager with sub-millimeter diameter can be inserted into tissue for minimally invasive in situ breast imaging. OCT imaging provides spatial resolution similar to histology and has the potential ...
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8. Optical coherence tomography vs fundus photography in detecting macular edema in subjects with type 2 diabetes (Thesis)
  
  Explore Home Aug 11 2020 Ophthalmology , Student Theses
  
  Introduction The screening of diabetic retinopathy has been relied on fundus photography but since it is 2-dimensional, it is difficult to identify diabetic macular edema (DME), which is the most feared ocular complication related to diabetes. Optical coherence tomography (OCT) has been shown to be a useful tool in detecting and monitoring DME. The main objective of this study was to screen people with type 2 diabetes and find out how many patients have current diabetic macular edema and to compare different screening equipment by means of fundus photography and OCT when evaluating macular edema. Method The sample of this ...
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9. Measuring 3D Optic Nerve Head Deformations using Digital Volume Correlation of in vivo Optical Coherence Tomography Data (Thesis)
  
  Explore Welcome to D Aug 5 2020 Ophthalmology , Student Theses
  
  The optic nerve head (ONH), located in the back of the eye, is a critical site in understanding the pathophysiology of glaucoma. However, longitudinal changes of the ONH as disease develops have not been well characterized. Our goal was to develop an improved tool to quantify these changes in an in vivo monkey model of glaucoma. Longitudinal spectral-domain optical coherence tomography (OCT) imaging of the ONH was performed every other week under manometric intraocular pressure (IOP) control (10 mmHg) in a monkey during baseline and after induction of unilateral experimental glaucoma. We developed a computational pipeline that applied digital volume ...
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  Mentions: University of Pittsburgh
10. Optical coherence tomography for characterization of nanocomposite materials (Thesis)
  
  Explore Publikationen in KITopen Aug 5 2020 NDE/NDT , Student Theses
  
  Nanocomposite materials play an increasingly important role in various application areas, be it in an industrial, medical or everyday environment. The unique properties of nanocomposites go beyond those of conventional composite materials. Because nanoparticles have a high surface-to-volume ratio such as carbon nanotubes, they can reinforce an embedding polymer host matrix mechanically, or they enhance the electrical material conductivity. A major challenge in the development of nanoparticles and nanocomposites is the control of particle size and shape, and of the uniform dispersion of nanoparticles in the host material. Conventional characterization techniques lack either resolution, or can only inspect details of ...
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11. Red-light Heartbeat Control and Optical Coherence Microscopy (OCM) Imaging in Drosophila (Thesis)
  
  Explore Log In Jul 16 2020 Developmental Biology , Student Theses
  
  would like to thank my advisor Prof. Chao Zhou, who gave me the opportunity to pursue a higher-level education in the United States, and led me to the field of biomedical engineering. I still have the impression that I was attracted by the fast heartbeat of a Drosophila Prof. Zhou showed with a video in his presentation in Peking University in 2014. I was curious that how the fast heartbeat could be tracked using OCT. Fortunately, I got the opportunity to join the group during that summer. In the next several years during my PhD period, Prof. Zhou guided me ...
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  Mentions: Lehigh University Chao Zhou
12. Functional High-Speed Optical Coherence Tomography (Thesis)
  
  Explore Log In Jul 16 2020 Student Theses
  
  Optical coherence tomography (OCT) is a high speed, high resolution, noninvasive imaging technique that has seen applications across many clinical and biological research fields, with a particular focus in ophthalmic, cardiologic and dermatologic imaging. Ultrahigh speed OCT imaging has become of interest for high resolution, widefield in vivo imaging. Space division multiplexing optical coherence tomography (SDM-OCT) is a novel optical coherence tomography system which utilizes a parallel imaging approach to achieve ultrahigh imaging speeds. In this dissertation we develop an ophthalmic SDM-OCT system to obtain widefield structural and angiographic images of the human retina in vivo. With an 800 kHz ...
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  Mentions: Lehigh University
13. Robotics and Virtual Reality for Optical Coherence Tomography-Guided Ophthalmic Surgery and Diagnostics (Thesis)
  
  Explore DukeSpace at Duke University Jul 14 2020 Ophthalmology , Student Theses
  
  Ophthalmology is the only surgical specialty that routinely employs both microsurgical techniques and live intraoperative imaging, especially optical coherence tomography (OCT). Consequently, ophthalmic surgeons routinely face challenges in visualization and manipulation of small ocular tissues or in interpreting intraoperative imaging to guide their actions. This dissertation therefore seeks to advance the state-of-the-art in ophthalmic surgery with regards to manipulation, visualization, and interpretation. First, we address the interpretation challenge in ophthalmic surgery where live volumetric imaging from OCT systems recently incorporated into surgical microscopes has freed surgeons from the otherwise universal top-down viewpoint. These new viewpoints, however, disorient surgeons when directions ...
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  Mentions: Duke University Mark Draelos
14. Advances in Optical Coherence Tomography for Retinal Oximetry and Angiography (Thesis)
  
  Explore Log In Jul 13 2020 Ophthalmology , Student Theses
  
  Optical coherence tomography (OCT) is a high-resolution, non-contact, three-dimensional imaging technique, which has revolutionized the diagnosis and treatment of retinal diseases. Visible-light OCT (vis-OCT) extends OCT by enabling retinal oximetry – the measurement of oxygen saturation of hemoglobin from within individual retinal blood vessels. Three advances in the vis-OCT technique are presented: an improved vis-OCT oximetry method based on circumpapillary scan and graph-search segmentation; the calibration, simulation, and correction of spectroscopic sensitivity rolloff for vis-OCT oximetry; and the measurement of the inner retinal oxygen metabolism in the 50/10 oxygen-induced retinopathy model, an animal model for human retinopathy of prematurity. Optical ...
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  Mentions: Northwestern University
15. The analysis of prostate tissue by optical coherence tomography (Thesis)
  
  Explore Research Explorer Jul 6 2020 Urology , Student Theses
  
  The prostate is the gland located around the urethra beneath the bladder that produces most of the sperm fluid (figure 1). Prostate cancer (PCa) accounted for almost 1 in 5 new cancer diagnoses in males in the USA in 2017, and 1 in 8 men will develop invasive cancer in the prostate in their lifetime [1]. Prostate cancer is the second most common cancer in men (after skin cancer) and the second most common cause of cancer-related death (after lung cancer). Advances in screening, diagnosis, and treatment have led to an overall survival increase from 69% in 1991-1995 to 89 ...
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  Mentions: Academic Medical Center at the University of Amsterdam
16. Invasive Coronary Artery Imaging Using Optical Coherence Tomography: A Cost-effectiveness and Implementation Process Analysis (Thesis)
  
  Explore TU Delft Institutional Repository Jul 1 2020 Cardiology , Student Theses
  
  The aim of this project was the implementation of optical coherence tomography (OCT), an invasive intracoronary imaging (ICI) tool used for the visualization of coronary arteries. The implementation was performed in a structured manner by: (1) A literature review into the current applications of OCT in relation to current standards; (2) A thesis feasibility study into clinical practices, professional views and other processes regarding ICI; (3) A Master’s thesis including a cost-effectiveness analysis (CEA) and the actual implementation of OCT at the department. The project started with a literature review about the current applications of OCT in relation to ...
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  Mentions: Delft University of Technology
17. DEVELOPMENT OF A LINE-FIELD MAGNETO-MOTIVE OPTICAL COHERENCE TOMOGRAPHY SYSTEM (Thesis)
  
  Explore Carolina Digital Repository Jun 30 2020 Student Theses
  
  The mechanism by which certain species of animals are able to detect the Earth’s magnetic field has remained a mystery for as long as we have known that they exhibit geomagnetic navigation. Certain species of bacteria are known to contain single chains of magnetite crystals, each with a diameter of ~50 nm, that are used to orient the bacteria. Searching for similar magnetoreceptors in larger animals requires a high-speed, high-resolution imaging system with the ability to detect single magnetic nanoparticles. Optical coherence tomography (OCT) is a biomedical imaging modality that produces 2D, cross-sectional images of optically turbid media with ...
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  Mentions: University of North Carolina
18. Classification of Neural Tissue Types for an Endoscopic Full-field Optical Coherence Tomography Imaging System (Thesis)
  
  Explore TSpace Repository Jun 29 2020 Student Theses
  
  Optical coherence tomography is a volumetric imaging technique that can differentiate brain regions with micron-scale resolution. Our group has previously developed an endoscopic full-field swept-source OCT system with the aim to provide real-time surgical guidance for the implantation of electrodes for deep brain stimulation. This thesis builds on our prior work. Due to the limitations in the resolution and contrast due to scattering from the tissue, to identify different types of neural tissues, we developed an image classification algorithm that use texture features and optical attenuation. The algorithm could classify three different brain regions in the ex vivo data set ...
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  Mentions: University of Toronto
19. Visible light spectroscopic optical coherence tomography for applications in neonatal healthcare (Thesis)
  
  Explore research.utwente.nl Jun 29 2020 Student Theses
  
  In this thesis, we explored the opportunities of spatially resolved optical spectroscopy for neonatal healthcare. Hereto, we developed a setup that makes use of spectroscopic optical coherence tomography (sOCT). This technique allows for spectroscopic measurement of the attenuation of light within a confined measurement volume, without being influenced by surrounding tissues. Throughout this thesis, we explored the possibilities of sOCT for estimating tissue properties which are relevant to newborns. In this way, we hope to contribute to neonatal healthcare by enabling a non-invasive alternative for invasive blood sampling and by enabling more scientific research into human milk and lactation. The ...
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  Mentions: University of Twente
20. Illuminating the trapeziometacarpal joint: Dawn for optical coherence tomography in osteoarthritis (Thesis)
  
  Explore UvA DARE Jun 15 2020 Student Theses
  
  Osteoarthritis (OA) is a debilitating degenerative joint disease affecting millions of patients worldwide and is characterized by loss of cartilage thickness and quality in affected joints. OA of the trapeziometacarpal (TMC) joint or thumb base joint especially gives rise to loss of hand function and disability. However, clinical imaging strategies have thus far been unable to accurately assess the thin cartilage layers lining small joints like the TMC joint. Moreover, a degree of discrepancy exists between clinical symptoms and OA features as seen on clinical imaging studies, hampering treatment choice. In an effort to eventually provide the clinician with additional ...
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  Mentions: Academic Medical Center at the University of Amsterdam
21. ASSESSING TERATOGEN-INDUCED CHANGES IN MURINE FETAL BRAIN VASCULATURE USING IN UTERO OPTICAL COHERENCE TOMOGRAPHY (Thesis)
  
  Explore Repository Home Jun 10 2020 Neurology , Student Theses
  
  This dissertation reports the use of in utero optical coherence tomography to evaluate changes in vasculature in a developing murine fetal brain caused due to prenatal exposure to teratogens. Embryogenesis is a highly complex process that is extremely vulnerable to external factors. Proper visualization of embryonic development is crucial to understand the basic physiological processes and identify defects if any. This dissertation is divided into two major sections: 1) assessing teratogen induced changes in the murine fetal brain vasculature during the second trimester equivalent period (chapters 2-4) and 2) combining optical coherence tomography with Brillouin microscopy to image and evaluate ...
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  Mentions: University of Houston
22. Optical reflectance contrast of micro- and nano-structures revealed with intravital micro-OCT (Thesis)
  
  Explore DR-NTU HOME Jun 5 2020 Student Theses
  
  Optical coherence tomography (OCT) provides depth-resolved three-dimensional images allowing the visualization of subsurface microstructures over large areas in situ and thus is a promising tool for epithelial disease screening. However, it has generally been relegated to a nonspecific diagnostic tool because the optical reflectance (back-scattering) contrast in OCT images is poorly understood although some contrast agents are available for OCT. This thesis focuses on elucidating the microstructural and ultrastructural bases underlying optical contrast to explore if OCT could provide diagnostic information in epithelial tissues with specificity. We investigate the back-scattered intensity of different intracellular scatterers at the micrometer and nanometer ...
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23. Investigating Local Polarisation Contrast With Fibre-Based Polarisation-Sensitive Optical Coherence Tomography and Microscopy (Thesis)
  
  Explore Pure API May 31 2020 Student Theses
  
  This thesis makes several important contributions to polarisation-sensitive optical coherence tomography (PS-OCT) through developing no el methods to effectively extract local contrast from birefringence and the orientation of the associated optic axis, at conventional and ultra-high resolution.
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  Mentions: University of Western Australia
24. Design and Characterization of Tunable LC-VCSELs for Optical Coherence Tomography (Thesis)
  
  Explore Home - Webthesis May 3 2020 Student Theses
  
  Optical Coherence Tomography (OCT) systems are making rapid progress into various areas ranging from medicine and health science up to non-medical areas such as quality control or biometrics. Various possible configurations are present in literature, but only a few exploit liquid crystals (LCs)-based device as a light source. The strength of OCT systems, compared with other three-dimensional imaging technologies, comes from a higher spatial resolution and a fast scanning rate that allows getting high-quality images of in vivo tissue samples. These qualities make OCT the perfect candidate for ophthalmology purpose, where the human eye moves quickly and randomly. The ...
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