Student Theses -Optical Coherence Tomography News

Articles in category: Student Theses

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1. Doppler optical coherence tomography for microcirculation studies (Thesis)
  
  Explore British Library EThOS Jul 5 2014 Dermatology , Velocimetry , Student Theses
  
  This thesis forms part of an ongoing long-term project to investigate the suitability of Doppler optical coherence tomography (OCT) as a measurement tool to investigate skin thickness and blood flow in patients with systemic sclerosis. There is a discussion of the characterisation of an electro-optic phase modulator for use in a Doppler OCT imaging system which is being built for the purpose of clinical studies. In addition to this the development of software for the same system is described. The work includes a comparison of two methods of obtaining Doppler information that were tested with the system; a phase resolved ...
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  Mentions: University of Manchester
2. Optical Coherence Tomography for Neurosurgery and Cancer Research (Thesis)
  
  Explore drum.lib.umd.edu Jun 29 2014 Neurology , Oncology , Student Theses
  
  Optical Coherence Tomography (OCT) provides non-labeling, real-time and high resolution images, which has the potential to transform the paradigm of surgical guidance and preclinical animal studies. The design and development of OCT devices for neurosurgery guidance and novel imaging algorithms for monitoring anti-cancer therapy have been pursued in this work. A forward-imaging needle-type OCT probe was developed which can fit into minimally invasive tools (I.D. ~ 1mm), detect the at-risk blood vessels, and identify tissue micro-landmarks. This promising guidance tool improves the safety and the accuracy of needle-based procedures, which are currently performed without imaging feedback. Despite the great imaging ...
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  Mentions: University of Maryland Yu Chen Chia-Pin Liang
3. Forward viewing OCT endomicroscopy (Thesis)
  
  Explore DSpace@MIT Jun 24 2014 Gastroenterology , Probes , Student Theses
  
  A forward viewing fiber optic-based imaging probe device was designed and constructed for use with ultrahigh speed optical coherence tomography in the human gastrointestinal tract. The light source was a MEMS-VCSEL at 1300 nm wavelength running at 300 kHz sweep rate, giving an effective A-line rate of 600 kHz. Data was acquired with a 1.8 GS/s A/D card optically clocked by a maximum fringe frequency of 1 GHz. The optical beam from the probe was scanned by a freely deflecting optical fiber that was mounted proximally on a piezoelectric tubular actuator, which was electrically driven in two ...
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  Mentions: Massachusetts Institute of Technology James G. Fujimoto
4. The qualitative assessment of biodegradable coronary stents with the use of intravascular ultrasound, optical coherence tomography and histology (Thesis)
  
  Explore edoc.ub.uni-muenchen.de Jun 10 2014 Cardiology , Student Theses
  
  Percutaneous coronary intervention (PCI) is the most common treatment for coronary artery disease (CAD). The first form of PCI introduced was balloon angioplasty. After that, the advent of coronary stents (tubular wire mesh for intravascular mechanical support) led to a new era in interventional cardiology. Through the implantation of bare metal stents (BMS), all three limitations of balloon angioplasty – coronary artery dissection, elastic recoil and negative remodelling – are prevented. Unfortunately, bare metal stents have their own drawbacks: most significantly, in-stent stenosis as a result of deep focal vascular injury caused by stent struts, followed by excessive tissue proliferation. This drawback ...
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  Mentions: Ludwig Maximilian University of Munich
5. Computational Evaluation of Shear Stress and Restenosis in Stented Coronary Arteries Using Optical Coherence Tomography (Thesis)
  
  Explore epublications.marquette.edu Jun 10 2014 Cardiology , Student Theses
  
  The cause of coronary artery neointimal thickness (NT) leading to restenosis in ~10% of drug-eluting stents (DES) is unknown, but adverse wall shear stress (WSS) may contribute. Prior studies comparing WSS to restenosis for first generation DES yielded conflicting results, and cited different mechanisms of action for DES agents. Studies to date have not accounted for stent geometry, which dictates local WSS patterns influencing drug concentration. The objective of this investigation was to evaluate current generation stent platforms via their WSS patterns and their respective impact on NT. We prospectively enrolled 19 patients, who were randomized to thin-strut (81μm ...
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6. Optical and Photoacoustic Imaging for Ovarian Cancer Detection (Thesis)
  
  Explore DigitalCommons@UConn Jun 5 2014 Gynecology , Oncology , Student Theses
  
  Ovarian cancer is the fifth most common cancer among women and has the highest mortality rate of all gynecologic cancers. Current clinical imaging modalities are limited by poor sensitivity and specificity. Therefore, there is an urgent need to develop effective tools to detect ovarian cancer. In this dissertation, two imaging modalities, optical coherence tomography (OCT) and photoacoustic imaging have been investigated for ovarian cancer detection and characterization. In the first modality, optical scattering coefficient, phase retardation and phase retardation rate were quantitatively extracted from polarization-sensitive OCT (PS-OCT) images. A highly positive correlation was found between those three parameters and collagen ...
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  Mentions: Quing Zhu Molly Brewer University of Connecticut
7. Development of Optical Coherence Tomography for Quantitative Analysis of Cardiac Morphology (Thesis)
  
  Explore Summit May 24 2014 Cardiology , Student Theses
  
  Transgenic mouse models have been instrumental in the elucidation of the molecular mechanism behind many cardiac diseases such as Marfan syndrome. However, the small size of the murine heart has hampered the characterization of its cardiac morphology. In this project, we describe the development of a murine cardiac imaging modality using optical coherence tomography (OCT). After fixation and optical clearing, the hearts were imaged from multiple perspectives. These data sets were then corrected for refraction and registered together to yield a single volume of the whole heart. From this OCT volume, we then applied techniques from computational anatomy to quantify ...
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  Mentions: Simon Fraser University
8. Share your OCT Thesis on OCT News
  
  Explore Optical Coherence Tomography News May 20 2014 Student Theses
  
  OCT News is seeking links to bachelors, masters, and PhD theses in the area of "Optical Coherence Tomography". Traditionally student theses contain a great wealth of information but are rarely accessible to the OCT community. If you or someone you know wrote an OCT thesis and would like to share it with the community please submit a link or PDF using the "Contact OCT News" tab in the main menu bar or the feedback link in the footer and we will include it here: Student Theses. Thesis will only be included if the link is free of charge to users.
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9. Improved inspection and micrometrology of embedded structures in multi-layered ceramics: Development of optical coherence tomographic methods and tools (Thesis)
  
  Explore diva-portal.org May 4 2014 NDE/NDT , Other Non-Medical , Student Theses
  
  Roll-to-roll manufacturing of micro components based on advanced printing, structuring and lamination of ceramic tapes is rapidly progressing. This large-scale and cost-effective manufacturing process of ceramic micro devices is however prone to hide defects within the visually opaque tape stacks. To achieve a sustainable manufacturing with zero defects in the future, there is an urgent need for reliable inspection systems. The systems to be developed have to perform high-resolution in-process quality control at high speed. Optical coherence tomography (OCT) is a promising technology for detailed in-depth inspection and metrology. Combined with infrared screening of larger areas it can solve the ...
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10. Adaptive optics optical coherence tomography for in vivo retinal imaging (Thesis)
  
  Explore Summit Apr 25 2014 Ophthalmology , Student Theses
  
  Optical coherence tomography (OCT) is a non-invasive micrometer-resolution volumetric imaging modality that has been employed in diverse applications. In this thesis, we first describe a GPU accelerated program to perform FDOCT data processing and real time 3D volumetric rendering. The real time visualization of volumetric images provided by the GPU acceleration was essential to the rest of the work described in this thesis. Small animal models of retinal diseases serve as a vital component in vision research, and non-invasive in vivo imaging is becoming an increasingly important tool in the field. We describe the first adaptive optics optical coherence tomography ...
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  Mentions: Marinko V. Sarunic Simon Fraser University Yifan Jian
11. Clinical applications of functional optical coherence tomography (Thesis)
  
  Explore UvA DARE Mar 19 2014 Gynecology , Urology , Student Theses
  
  The purpose of the work presented in this thesis is to show the potential of functional optical coherence tomography (OCT) to discriminate pathological from normal tissues in several clinical settings, by means of the attenuation coefficient. To that end, several fundamental studies were carried out to increase the fundamental understanding of the measured signals (in phantoms, during apoptosis) and both ex and in vivo investigations are performed in the urological and gynecological clinic.
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  Mentions: Dirk J. Faber Frank D. Verbraak Ton G. van Leeuwen
12. In vivo evaluation of neointimal healing after stenting with optical coherence tomography (Thesis)
  
  Explore repub.eur.nl Feb 25 2014 Cardiology , Student Theses
  
  Ischemic heart disease is still today the first cause of mortality in the world, especially in the developed countries. The vast majority of cases are due to atherosclerosis, a complex systemic degenerative process resulting in cholesterol accumulation in the extra-cellular space of the arterial intima, with inflammation, foam-cells formation, and necrosis. The clinical manifestations of coronary atherosclerosis comprise from stable angina, due to flow-limiting stenosis of the artery, to acute myocardial infarction or sudden death, when the atheroma gets complicated by thrombotic phenomena. The first revolution in the treatment of this disease came in 1977, when Andreas Grüntzig performed ...
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  Mentions: Patrick W. Serruys Erasmus University Juan Luis Gutiérrez-Chico
13. Angiography and Monitoring of Hemodynamic Signals in the Brain via Optical Coherence Tomography (Thesis)
  
  Explore UWM Digital Commons Feb 20 2014 Neurology , Student Theses
  
  The brain is a complex network of interconnected neurons with each cell functioning as a nonlinear processing unit. Neural responses to stimulus can be described by activity in neurons. While blood flow changes have been associated with neural activity and are critical to brain function, this neurovascular coupling is not well understood. This work presents a technique for neurovascular interrogation, combining optogenetics and optical coherence tomography. Optogenetics is a recently developed neuromodulation technique to control activity in the brain using light with precise spatial neuronal control and high temporal resolution. Using this method, cells act as light-gated ion channels and ...
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  Mentions: University of Wisconsin
14. Quantification of the neurodegenerative status in patients with multiple sclerosis by optical coherence tomography in respect to functional vision (Thesis)
  
  Explore diss.fu-berlin.de Feb 18 2014 Neurology , Ophthalmology , Student Theses
  
  Multiple sclerosis is the most frequent, non-traumatic, neurological disorder in young adults in western countries which leads to chronic impairment. The cause of the immune mediated illness remains elusive. Neither clinical nor paraclinical measures can estimate the disability degree or the course of multiple sclerosis (MS). It is crucial to improve the methods which can be a window to the neurodegenerative status of individuals. Structural investigations of the ZNS by MRI own a key position but discriminate between demyelinisation and axonal damage insufficiently and show a discrepancy between lesion load and clinical symptoms. The axonal degeneration goes in line with ...
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15. The Clinical Application of Optical Coherence Tomography for Head and Neck Premalignant/Malignant Lesions (Thesis)
  
  Explore UCL Discovery Feb 12 2014 Student Theses
  
  Abstract The principle of Optical Coherence Tomography (OCT) is based on the property of light coherence. OCT generates cross-sectional images of two-dimensional objects to obtain in-vitro and in-vivo images of tissues. Non–commercially available OCT systems, which have a higher resolution and scanning rate, have been previously reported. However, some clinical research has already been conducted using the first commercially available OCT device (Niris system) to image the larynx; but applications on oral and skin tissue have not been tested yet. This thesis aims to explore, compare and validate three specific types of commercially available OCT equipment for imaging head ...
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  Mentions: University College London Imalux Niris
16. Imaging the Electro-Kinetic Response of Biological Tissues with Optical Coherence Tomography (Thesis)
  
  Explore Digital Commons @ Ryerson Feb 3 2014 Student Theses
  
  This thesis reports on developing a novel approach to imaging the electro-kinetic response of biological tissues with optical coherence tomography (OCT). The changes of backscattered OCT signal from tissues were investigated with a low frequency AC electric field being applied to the tissues. Advanced processing algorithms were developed to analyze the amplitude and phase changes of OCT signal. Two-dimensional electrically induced optical changes (EIOC) amplitude and phase images related to the electro-kinetic response of soft tissues were obtained with depth resolution and compared with structural OCT images. The procedure for removing the background noise from EIOC images was introduced.
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  Mentions: Ryerson University
17. The Role of Novel Biophotonic Technique in Characterization of the Newly Developed Nanotechnology based Dental Composites (Thesis)
  
  Explore Optical Coherence Tomography News Feb 3 2014 Dentistry , Student Theses
  
  [Background and Objective]: Polymerization shrinkage and the associated contraction stresses are the major shortcoming of dental composites in dentistry, which may affect the bonding performance and result in gap formation at the tooth-restoration interface. Non-destructive assessment and monitoring of these defects are critically important. The aim of this study is to assess the toothrestoration interface and composite adaptation using swept source optical coherence tomography (SS-OCT) in combination of microtensile bond strength (MTBS) and to confirm the findings with confocal laser scanning microscope (CLSM) and scanning electron microscopy (SEM). [Materials and Methods]: Standard round class-I cavities were prepared in human premolar ...
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  Mentions: Turki Bakhsh
18. The design, development and application of a dual-beam spectral-domain optical coherence tomography system for the non-invasive assessment of vascular dynamics by statistical means (Thesis)
  
  Explore Community List Feb 2 2014 Student Theses
  
  This assertion underscores the importance of haematological dynamic assessment, which can benefit greatly from non-invasive high-resolution imaging of blood flow especially at the microvascular level. This importance is further highlighted in oncological applications with recent emphasis on tumour vasculature, angiogenic processes and developments of anti-angiogenic therapies. Optical coherence tomography (OCT) has established itself a firm foothold in the realm of non-invasive optical medical diagnostic imaging, enabling in vivo cross-sectional tomographic visualisation of the internal microstructure of biological systems, and is now considered an optical analogue to CT or MRI, but with microscopic resolution. The original concept of OCT was to ...
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  Mentions: University of Limerick Martin J. Leahy
19. Optical Coherence Tomography as a Characterization Method in Printed Electronics (Thesis)
  
  Explore jultika.oulu.fi Dec 18 2013 Other Non-Medical , Student Theses
  
  This Thesis proposes and describes the use of optical coherence tomography (OCT) as a non-contact and non-destructive characterization technique for printed electronics. It is based on and includes the first published results of such an application of the OCT technique. Several different types of structures were studied to evaluate the feasibility of the application. The measurement data was used to define the surface topography, physical dimensions of the specimen features, and to evaluate the ability to characterize multi-layered and multi-material structures. Presented OCT measurements were done for: screen-printed conductive and insulating structures, microfluidic channels, microscopy glass and organic field effect ...
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  Mentions: Risto A. Myllylä University of Oulu Jakub Czajkowski
20. Integrated-optics-based optical coherence tomography (Thesis)
  
  Explore UvA DARE Oct 19 2013 Student Theses
  
  Optical coherence tomography (OCT) is a high resolution, imaging technique that has developed over the last 20 years from a complicated laboratory setup into a ready-to-use commercially available device. Instead of using electronic time gating as being used by ultrasound (US) imaging, in OCT, the optical analogue of US imaging, determines the time of flight using low coherence interferometry. To date, OCT has many clinical applications and is widely used in urology, cardiovascular imaging, dentistry, dermatology and ophthalmology. Currently OCT devices are bulky and expensive, which limits the use of OCT, not only in its existing applications, but also in ...
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  Mentions: Academic Medical Center at the University of Amsterdam Jeroen Kalkman Ton G. van Leeuwen
21. Multi-Modality Endoscopic Imaging for the Detection of Colorectal Cancer (Thesis)
  
  Explore arizona.openrepository.com Sep 24 2013 Gastroenterology , Oncology , Student Theses
  
  Optical coherence tomography (OCT) is an imaging method that is considered the optical analog to ultrasound, using the technique of optical interferometry to construct two-dimensional depth-resolved images of tissue microstructure. With a resolution on the order of 10 μm and a penetration depth of 1-2 mm in highly scattering tissue, fiber optics-coupled OCT is an ideal modality for the inspection of the mouse colon with its miniaturization capabilities. In the present study, the complementary modalities laser-induced fluorescence (LIF), which offers information on the biochemical makeup of the tissue, and surface magnifying chromoendoscopy, which offers high contrast surface visualization, are combined ...
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  Mentions: University of Arizona
22. Characterization and Modeling of an O-Band 1310 nm Sampled-Grating Distributed Bragg Reflector (SG-DBR) Laser for Optical Coherence Tomography (OCT) Applications (Thesis)
  
  Explore DigitalCommons@CalPoly Aug 1 2013 Tunable Sources , Student Theses
  
  In this project, the performance aspects of a new early generation 1310 nm Sampled-Grating Distributed Bragg Reflector (SG-DBR) semiconductor laser are investigated. SG-DBR lasers are ideal for Source Swept Optical Coherence Tomography (SS-OCT), a Fourier-Domain based approach for OCT, necessitating a tunable wavelength source. Three internal sections control the frequency output for tuning, along with two amplifiers for amplitude control. These O-band SG-DBR devices are now being produced in research quantities. SG-DBR lasers have been produced at 1550 and 1600 nm for some times. Fundamental questions regarding the performance of the 1310 nm devices must be quantified. Standard metrics including ...
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  Mentions: Dennis Derickson
23. Development of Spectral Domain Optical Coherence Tomography for in vivo Functional Imaging of Biological Tissues (Thesis)
  
  Explore digital.lib.washington.edu Jul 30 2013 Student Theses
  
  Optical coherence tomography is a rapidly developing optical imaging modality capable of noninvasively providing depth resolved information of biological tissue at micrometer scale. Since its first report in 1991, it has made tremendous progress leading to successful applications in a number of fields, such as ophthalmology, gastroenterology, dermatology, dentistry, dermatology, cardiology, etc. According to [1], there are more than 15, 000 OCT units that had been put into service in ophthalmic clinic by 2009, which represented approximately $ 1 billion market. The total amount paid by Medicare for OCT scans has increased from $ 1 billion per year in 2001 to $ 7 ...
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  Mentions: University of Washington FDA Lin An
24. Examination of Diagnostic Features in Multiphoton Microscopy and Optical Coherence Tomography Images of Ovarian Tumorigenesis in a Mouse Model (Thesis)
  
  Explore arizona.openrepository.com Jun 11 2013 Gynecology , Oncology , Student Theses
  
  Ovarian cancer is a deadly disease owing to the non-specific symptoms and suspected rapid progression, leading to frequent late stage detection and poor prognosis. Medical imaging methods such as CT, MRI and ultrasound as well as serum testing for cancer markers have had extremely poor performance for early disease detection. Due to the poor performance of available screening methods, and the impracticality and ineffectiveness of taking tissue biopsies from the ovary, women at high risk for developing ovarian cancer are often advised to undergo prophylactic salpingo-oophorectomy. This surgery results in many side effects and is most often unnecessary since only ...
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  Mentions: University of Arizona
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