Category: Student Theses

1. Organizations in the News

   (22 articles) Massachusetts Institute of Technology

   (7 articles) University of Arizona

   (5 articles) Case Western Reserve University

   (4 articles) University of Oulu

   (4 articles) University of Western Australia

   (3 articles) The Ohio State University

   (3 articles) Harvard University

   (3 articles) Massachusetts General Hospital

   (3 articles) California Institute of Technology

   (2 articles) University of Texas at Arlington

2. People in the News

   (13 articles) James G. Fujimoto

   (6 articles) Jennifer K. Barton

   (5 articles) Andrew M. Rollins

   (4 articles) Risto A. Myllylä

   (4 articles) David D. Sampson

   (2 articles) Changhuei Yang

   (2 articles) Costas D. Pitris

   (2 articles) David Huang

   (2 articles) Joseph A. Izatt

   (2 articles) Brett E. Bouma

1. Share your OCT Thesis on OCT News

   Explore Article Optical Coherence Tomography News (Nov 13 2009) Student Theses

   OCT News is seeking links to bachelors, masters, and PhD theses in the area of "Optical Coherence Tomography".  traditionally student thesis contain a great wealth of information but are rarely accessible to the OCT community.  If you or someone you know did an OCT thesis please submit a link or P
   

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2. Validation of Optical Coherence Tomography-Based Crystalline Lens Thickness Measurements in Children (Thesis)

   Explore Article OhioLINK ETD Center (Jun 1 2009) Ophthalmology , Student Theses

   The purpose of this study was to evaluate the validity and repeatability of crystalline lens thickness measurements obtained by anterior segment optical coherence tomography (OCT). Optical coherence tomography utilizes infrared light and partial-coherence interferometry to produce a two-dimensional scan of the internal ocular structures in vivo. Changes in crystalline lens thickness are important to monitor for refractive error development, cataract progression, and anterior chamber alterations. Our goal was to develop an effective method of measuring the thickness of the crystalline lens with the Visante anterior segment OCT, to assess OCT repeatability, and to evaluate OCT validity as compared to A-scan ...
   

   Comment on Article Mentions:   The Ohio State University

3. Anterior Segment Optical Coherence Tomography-Based Phakometry Measurements in Children (Thesis)

   Explore Article OhioLINK ETD Center (Jun 1 2009) Ophthalmology , Student Theses

   Anterior segment optical coherence tomography (AS-OCT) is emerging as a valuable tool for in vivo ocular biometry. This study constitutes the first known attempt at in vivo assessment of crystalline lens curvature using AS-OCT technology. METHODS: An ASOCT phakometry protocol was compared to video-based phakometry data on a sample of 42 children. RESULTS: AS-OCT phakometry demonstrated poor 95% limits of agreement (LOA) and significant magnitude bias, yielding excessively flat radii when used to measure flatter surfaces (anterior: P < 0.001, LOA = -8.82 to +6.52 mm; posterior: P < 0.001, LOA = -1.13 to +1.67 mm). Orthogonal regression-derived correction neutralized ...
   

   Comment on Article Mentions:   The Ohio State University

4. The Use of Intracoronary Optical Coherence Tomography in Interventional Cardiology: Safety, Feasibility and Clinical Applications (Thesis)

   Explore Article repub.eur.nl (May 27 2009) Cardiology , Student Theses

   Interventional cardiology has witnessed tremendous change since 1977 when Andreas Gruentzig successfully performed the first balloon angioplasty. Whereas initial concerns revolved around maintaining vessel patency with issues of recoil and restenosis, the introduction of stents changed the landscape forever. Inherent with their use, stents, and, more specifically, drugeluting stents (DES), have become central to improved patient outcomes but, at some cost. Catastrophic, yet fortunately still rare complications such as stent thrombosis have re-ignited an intense need for greater scrutiny when developing and, subsequently implanting DES into our patients. The demand for detailed information regarding coronary artery disease has seen intravascular ...
   

   Comment on Article Mentions:   Peter Barlis   Thoraxcenter at Erasmus University Medical Center   Carlo Di Mario

5. Image analysis of Optical Coherence Tomography images of the urinary bladder for the recognition of bladder cancer (Thesis)

   Explore Article catalog.wrlc.org (Jan 31 2009) Oncology , Urology , Student Theses

   The vast majority of bladder cancers originate within 600 mum of the tissue surface, making Optical Coherence Tomography (OCT) a potentially powerful tool for recognizing cancers that are not easily visible with current techniques. OCT is a new technology, however, and surgeons are not familiar with the resulting images. Technology able to analyze and provide diagnoses based on OCT images would improve the clinical utility of OCT systems. In addition, to avoid the need for gathering training data sets each time a new OCT system is used, it is important that the technology developed be system-independent. In this dissertation, I ...
   

   Comment on Article Mentions:   George Washington University   Jason M. Zara   Washington University in St. Louis

6. Optical Imaging Modalities: From Design to Diagnosis of Skin Cancer (Thesis)

   Explore Article Electronic Theses and Dissertations (Jan 1 2009) Dermatology , Oncology , Student Theses

   This study investigates three high resolution optical imaging modalities to better detect and diagnose skin cancer. The ideal high resolution optical imaging system can visualize pre-malignant tissue growth non-invasively with resolution comparable to histology. I examined 3 modalities which approached this goal. The first method examined was high magnification microscopy of thin stained tissue sections, together with a statistical analysis of nuclear chromatin patterns termed Karyometry. This method has subcellular resolution, but it necessitates taking a biopsy at the desired tissue site and imaging the tissue ex-vivo. My part of this study was to develop an automated nuclear segmentation algorithm ...
   

   Comment on Article Mentions:   Jennifer K. Barton   University of Arizona

7. Functional Spectral Domain Optical Coherence Tomography Imaging (Thesis)

   Explore Article DukeSpace at Duke University (Jan 1 2009) Ophthalmology , Student Theses

   Spectral Domain Optical Coherence Tomography (SDOCT) is a high-speed, high resolution imaging modality capable of structural and functional resolution of tissue microstructure. SDOCT fills a niche between histology and ultrasound imaging, providing non-contact, non-invasive backscattering amplitude and phase from a sample. Due to the translucent nature of the tissue, ophthalmic imaging is an ideal space for SDOCT imaging. Structural imaging of the retina has provided new insights into ophthalmic disease. The phase component of SDOCT images remains largely underexplored, though. While Doppler SDOCT has been explored in a research setting, it remains to catch on in the clinic. Other, functional ...
   

   Comment on Article Mentions:   Joseph A. Izatt   Duke University   Bradley A. Bower

8. Coherence domain optical imaging techniques (Thesis)

   Explore Article Welcome to CaltechTHESIS (Nov 25 2008) Student Theses

   Coherence domain optical imaging techniques have been developing quickly in the past few decades after the invention of laser. In this thesis, I will report the imaging methods that constitute my research projects during these years of graduate studies, including paired-angle-rotation scanning (PARS) forward-imaging probe for optical coherence tomography (OCT), full-field phase imaging technique based on harmonically matched diffraction grating (G1G2 grating), and Fresnel zone plate (FZP) based optifluidic microscopy (OFM). Compared with conventional optical microscopy, the coherence domain optical imaging has many advantages and greatly extends the application of imaging techniques. OCT, based on low-coherence interferometry, is a high-resolution ...
   

   Comment on Article Mentions:   California Institute of Technology   Jigang Wu   Changhuei Yang

9. Spectral/ Fourier domain Doppler Optical Coherence Tomography in the rodent retina (Thesis)

   Explore Article DSpace@MIT (Sep 1 2008) Ophthalmology , Student Theses

   Optical Coherence Tomography (OCT) is an emerging imaging technique based on low-coherence interferometry for noninvasive, high- resolution, cross-sectional imaging in a variety of biomedical fields. In ophthalmology, OCT has rapidly become a standard clinical diagnostic tool for retinal diseases, providing visualization of the retina with unprecedented detail. However, conventional time domain OCT systems are limited by low imaging speeds. Conventional time domain OCT systems use a mechanically scanned reference mirror to adjust the reference arm path length in time. Spectral / Fourier domain OCT systems use a spectrometer to detect the interference spectrum and do not require mechanical scanning of ...
   

   Comment on Article Mentions:   Massachusetts Institute of Technology   James G. Fujimoto   Jonathan J. Liu

10. Plasmon Resonant Nanostructures of Gold for Biomedical Applications (Thesis)

    Explore Article Electronic Theses and Dissertations (Aug 21 2008) Student Theses

    Advanced optical imaging techniques are emerging as useful ways to screen tissues for the presence of cancer. Plasmon resonant nanoparticles have unique optical properties that make them ideal for use as optical contrast agents. The capacity of these particles to serve a multifunctional role dependent on their composition and the intensity of incident light enables them to serve as diagnostic tools and to provide the therapeutic capability of photo-thermal energy conversion or the controlled release of an encapsulated agent. Likewise, the ability to degrade into components of a clearable size may enable the clinical translation of these types of particles. ...
    

    Comment on Article Mentions:   Jennifer K. Barton   University of Arizona

11. Novel Biomedical Imaging Systems (Thesis)

    Explore Article Electronic Theses and Dissertations (Aug 11 2008) Student Theses

    The overall purpose of the dissertation is to design and develop novel optical imaging systems that require minimal or no mechanical scanning to reduce the acquisition time for extracting image data from biological tissue samples. Two imaging modalities have been focused upon: a parallel optical coherence tomography (POCT) system and a volume holographic imaging system (VHIS). Optical coherence tomography (OCT) is a coherent imaging technique, which shows great promise in biomedical applications. A POCT system is a novel technology that replaces mechanically transverse scanning in the lateral direction with electronic scanning. This will reduce the time required to acquire image ...
    

    Comment on Article Mentions:   University of Arizona

12. Image Processing and Clinical Applications of Anterior Segment Optical Coherence Tomography (Thesis)

    Explore Article OhioLINK ETD Center (Jul 20 2008) Ophthalmology , Student Theses

    Optical coherence tomography (OCT) is an emerging imaging modality. It provides in vivo cross-sectional images with micron level resolution. OCT is attractive for imaging the anterior eye segment because of its characteristics on high resolution, non-contact, and easy anatomical interpretation. The fast data acquisition rate (>2000 axial scans per second) of current anterior segment OCT systems allows the measurement of corneal dimensions without significant motion error. It also generates huge amount of data. Manual anatomic reconstruction and measurement are time consuming and operator-dependent. Automated image processing and analysis techniques can overcome these limitations and make routine clinical use of OCT ...
    

    Comment on Article Mentions:   Andrew M. Rollins   Case Western Reserve University   Yan Li

13. 1.2-Micron Multi-Section Quantum Dot Superluminescent Diodes (Thesis)

    Explore Article DSpaceUNM (Jul 1 2008) Broadband Sources , Student Theses

    Superluminescent diodes (SLD) with a center wavelength of 1.2µm are of interest for use in medical imaging of skin tissue especially in the field of optical coherence tomography (OCT). In this thesis a ridge-waveguide multi-section quantum dot SLD that emits at 1.2µm with a bandwidth greater than 100nm and a power greater than 0.2mW is presented. The multi-section SLD allows simultaneous tuning of the ground state emission and excited state emission, resulting in wide bandwidth and high power. Theoretical equations describing the intensity output of the multi-section SLD configuration are presented. It is found that these equations are able to ...
    

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14. Development of Fourier Domain Optical Coherence Tomography for Applications in Developmental Biology (Thesis)

    Explore Article DukeSpace at Duke University (Jun 5 2008) Developmental Biology , Student Theses

    Developmental biology is a field in which explorations are made to answer how an organism transforms from a single cell to a complex system made up of trillions of highly organized and highly specified cells. This field, however, is not just for discovery, it is crucial for unlocking factors that lead to diseases, defects, or malformations. The one key ingredient that contributes to the success of studies in developmental biology is the technology that is available for use. Optical coherence tomography (OCT) is one such technology. OCT fills a niche between the high resolution of confocal microscopy and deep imaging ...
    

    Comment on Article Mentions:   Joseph A. Izatt   Duke University   Anjul M. Davis

15. Phase-sensitive light: coherence theory and applications to optical imaging (Thesis)

    Explore Article DSpace@MIT (Jun 1 2008) Student Theses

    Spontaneous parametric downconversion (SPDC) can produce pairs of entangled photons, i.e., a stream of biphotons. SPDC has been utilized in a number of optical imaging applications, such as optical coherence tomography, ghost imaging, holography and lithography, to obtain performance that cannot be realized with standard optical sources. However, a debate continues as to whether the improved imaging characteristics of such systems should be attributed to the entanglement property of the photon pairs. This thesis sets out to unify--and generalize--classical and quantum imaging within the framework of Gaussian-state light fields, which encompasses thermal light--the source used in conventional imagers--and biphoton-state light ...
    

    Comment on Article Mentions:   Massachusetts Institute of Technology   Jeffrey H. Shapiro   Baris I. Erkmen

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