1. Articles in category: Neurology

    673-693 of 693 « 1 2 ... 26 27 28 29
    1. Optical coherence tomography and disease subtype in multiple sclerosis.

      OBJECTIVE: To examine retinal nerve fiber layer (RNFL) thickness, macular volumes (MV), and visual acuity in multiple sclerosis (MS) eyes, with and without history of acute optic neuritis (ON). METHODS: RNFL thickness was measured in 326 MS and 94 control eyes using optical coherence tomography (OCT). MV and vision testing were done in a subset of the cohort. MS subtype was classified as relapsing-remitting (RRMS, n = 135), primary progressive (PPMS, n = 12), and secondary progressive (SPMS, n = 16). RESULTS: MS ON eyes had decreased RNFL thickness (84.2 microm) compared to controls (102.7 microm) (p PMID: 18040015 [PubMed - in ...
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    2. Retinal nerve fiber layer thickness is associated with brain MRI outcomes in multiple sclerosis.

      Multiple sclerosis is characterized by the dual pathological processes of inflammation and neurodegeneration. Conventional MRI techniques are considered the best tools for assessing and monitoring lesion burden and inflammation but are limited in their ability to assess axonal loss. Optical coherence tomography (OCT) is a simple high-resolution technique that uses near infrared light to quantify the thickness of the retinal nerve fiber layer (RNFL), which contains only non-myelinated axons. RNFL thickness (RNFLT) was measured using OCT on thirty consecutive MS patients (60 eyes). Eighteen patients underwent quantitative MRI analysis including T1- and T2-lesion volumes (LV), normalized brain volume (NBV), normalized ...
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    3. Is optical coherence tomography really a new biomarker candidate in multiple sclerosis? A structural and functional evaluation.

      Related Articles Is optical coherence tomography really a new biomarker candidate in multiple sclerosis? A structural and functional evaluation. Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5773-81 Authors: Gundogan FC, Demirkaya S, Sobaci G PURPOSE: To assess the structural and functional status of patients with multiple sclerosis (MS) without a history of optic neuritis. METHODS: Thirty-nine patients with MS who had reported no visual symptoms before and after the time of MS diagnosis were included. Thirty-eight healthy subjects were included as a control group. Retinal nerve fiber layer (RNFL) thickness was determined by optical coherence tomography. Pattern visual evoked ...
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    4. The Relationship between Visual Field and Retinal Nerve Fiber Layer Measurements in Patients with Multiple Sclerosis.

      Related Articles The Relationship between Visual Field and Retinal Nerve Fiber Layer Measurements in Patients with Multiple Sclerosis. Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5798-805 Authors: Cheng H, Laron M, Schiffman JS, Tang RA, Frishman LJ PURPOSE: To investigate the relationship between visual function, measured by standard automated perimetry (SAP), and retinal nerve fiber layer (RNFL) thickness, measured by optical coherence tomography (OCT), in patients with multiple sclerosis (MS). METHODS: SAP and RNFL thickness were measured in patients with MS in 28 eyes with the last optic neuritis (ON) >/=6 months prior (ON group) and 33 eyes without ...
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    5. An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography.

      Related Articles An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography. Brain. 2007 Dec 4; Authors: Henderson AP, Trip SA, Schlottmann PG, Altmann DR, Garway-Heath DF, Plant GT, Miller DH Axonal loss is thought to be the predominant cause of disability in progressive multiple sclerosis (MS). The retinal nerve fibre layer (RNFL) is composed largely of unmyelinated axons of retinal ganglion cells, and is accessible to study with optical coherence tomography (OCT), giving a measure of axonal loss. OCT measures of the RNFL thickness (RNFLT) and macular volume were studied in 23 patients ...
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    6. Optical coherence tomography and disease subtype in multiple sclerosis

      Optical coherence tomography and disease subtype in multiple sclerosis. by multiplesclerosis on Mon 10 Dec 2007 12:00 AM CST | Permanent Link | Cosmos Optical coherence tomography and disease subtype in multiple sclerosis. Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. OBJECTIVE: To examine retinal nerve fiber layer (RNFL) thickness, macular volumes (MV), and visual acuity in multiple sclerosis (MS) eyes, with and without history of acute optic neu
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    7. An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography

      Axonal loss is thought to be the predominant cause of disability in progressive multiple sclerosis (MS). The retinal nerve fibre layer (RNFL) is composed largely of unmyelinated axons of retinal ganglion cells, and is accessible to study with optical coherence tomography (OCT), giving a measure of axonal loss. OCT measures of the RNFL thickness (RNFLT) and macular volume were studied in 23 patients with primary progressive multiple sclerosis (primary progressive MS) (13 male; 10 female; mean age 52 years; median EDSS 6.0; mean disease duration 11 years), and 27 patients with secondary progressive multiple sclerosis (secondary progressive MS) (8 ...
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    8. The Relationship between Visual Field and Retinal Nerve Fiber Layer Measurements in Patients with Multiple Sclerosis

      purpose. To investigate the relationship between visual function, measured by standard automated perimetry (SAP), and retinal nerve fiber layer (RNFL) thickness, measured by optical coherence tomography (OCT), in patients with multiple sclerosis (MS). methods. SAP and RNFL thickness were measured in patients with MS in 28 eyes with the last optic neuritis (ON) ≥6 months prior (ON group) and 33 eyes without ON history (non-ON group). Abnormal overall or quadrant RNFL thickness was defined by measured values below 5% of the norm. A whole visual field or a sector of the field was classified as abnormal by using cluster criteria ...
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    9. Is Optical Coherence Tomography Really a New Biomarker Candidate in Multiple Sclerosis? A Structural and Functional Evaluation

      purpose. To assess the structural and functional status of patients with multiple sclerosis (MS) without a history of optic neuritis. methods. Thirty-nine patients with MS who had reported no visual symptoms before and after the time of MS diagnosis were included. Thirty-eight healthy subjects were included as a control group. Retinal nerve fiber layer (RNFL) thickness was determined by optical coherence tomography. Pattern visual evoked potentials (PVEP), full-field electroretinogram (ERG), and multifocal electroretinogram (mfERG) were performed. results. There was a significant reduction (P = 0.011) only in temporal RNFL thickness in patients with MS. P100 latency was significantly delayed with ...
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    10. Optical coherence tomography and disease subtype in multiple sclerosis

      Objective: To examine retinal nerve fiber layer (RNFL) thickness, macular volumes (MV), and visual acuity in multiple sclerosis (MS) eyes, with and without history of acute optic neuritis (ON). Methods: RNFL thickness was measured in 326 MS and 94 control eyes using optical coherence tomography (OCT). MV and vision testing were done in a subset of the cohort. MS subtype was classified as relapsing-remitting (RRMS, n = 135), primary progressive (PPMS, n = 12), and secondary progressive (SPMS, n = 16). Results: MS ON eyes had decreased RNFL thickness (84.2 µm) compared to controls (102.7 µm) (p p p p p ...
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    11. Eye scan helps detect multiple sclerosis

      Eye scan helps detect multiple sclerosis
      by MT Bureau - October 17, 2007 - 0 comments Baltimore -- U.S. researchers suggest an eye exam that takes five minutes could become an inexpensive and effective way to gauge and track multiple sclerosis, or MS. Baltimore -- U.S. researchers suggest an eye exam that takes five minutes could become an inexpensive and effective way to gauge and track multiple sclerosis, or MS. The study, published in Neurology, used optical coherence tomography to scan optic
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    12. Eye Scan May Help Diagnose, Treat MS

      MONDAY, Oct. 15 (HealthDay News) -- A short and simple eye scan not only appears capable of spotting multiple sclerosis earlier in the course of the disease, but might also provide a way to track progression of the illness, as well as the effectiveness new drugs in development, researchers say. "We're in the process of validating this for clinical utility," said Dr. Peter Calabresi, lead author of the study and director of the Johns Hopkins Multiple Sclero
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    13. Eye Scan May Help Diagnose, Treat MS

      The inexpensive test could lead to new drugs, researchers add By Amanda Gardner Posted 10/15/07 MONDAY, Oct. 15 (HealthDay News) -- A short and simple eye scan not only appears capable of spotting multiple sclerosis earlier in the course of the disease, but might also provide a way to track progression of the illness, as well as the effectiveness new drugs in development, researchers say. Related News * Video: Health News & Features * Health Community * More
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    14. Eye Scan for MS

      Health Encyclopedia: Neurological Disorders Myelofibrosis Chronic Inflammatory Demyelinating Polyneuropathy Neurological Disorder News Scientists Find Way to Track Stem Cells in Brain After a Stroke, Every Second Counts Scientists Spot Brain Center for 'Out-of-Body' Experience Pediatricians' Group Issues New Autism Guidelines Certain Seizure Patients Need Emergency CT Scan Brain Region Tied to Amphetamine Addiction Scientists Spot Eye Development 'Switch' Oral Thermometers Ca
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    15. Optical Coherence Tomography for Multiple Sclerosis

      * A group of investigators from Johns Hopkins studied 40 multiple sclerosis (MS) patients with optical coherence tomography (OCT) of the eye (see flashbacks below about the technology), and found that this technique offers a potentially new, cost-effecti... ... Medgadget, Thursday, October 18, 2007 © 2007 SpaceRef Interactive Inc. All rights reserved
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    16. Optical Coherence Tomography Could Track Brain Shrinkage In MS Patients

      Optical Coherence Tomography Could Track Brain Shrinkage In MS Patients
      A five-minute eye exam might prove to be an inexpensive and effective way to gauge and track the debilitating neurological disease multiple sclerosis, potentially complementing costly magnetic resonance imaging to detect brain shrinkage - a characteristic of the disease’s progression. A Johns Hopkins-based study of a group of 40 multiple sclerosis (MS) patients used a process called optical coherence tomography (OCT) to scan the layers of nerve fibers of the retina in the back of the eye, which become the optic nerve. The process, which uses a desktop machine similar to a slit-lamp, is simple and painless. The retinal nerve ...
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    17. Systems and methods for making noninvasive physiological assessments

      Systems and methods for assessment of tissue properties, noninvasively, by acquiring data relating to at least one aspect of intrinsic and/or induced tissue displacement, or associated biological responses, are provided. Data relating to tissue displacement and associated biological changes may be acquired by detecting acoustic properties of tissue using ultrasound interrogation pulses, preferably in a scatter or Doppler detection mode. Based on this data, tissue properties are assessed, characterized and monitored. Specific applications for systems and methods of the present invention include non-invasive assessment and monitoring of intracranial pressure (ICP), arterial blood pressure (ABP), CNS autoregulation status, vasospasm, stroke ...
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    18. Optical measurement of neural action potentials using low coherence heterodyne interferometry (Thesis)

      Optical measurement of neural action potentials using low coherence heterodyne interferometry (Thesis)
      We present a novel non-invasive optical method for detection of neural action potentials using low coherence interferometry. The dual beam heterodyne interferometer (DBHI) is a modified Michelson with a low coherence source and an optical referencing method capable of detecting sub-nanometer optical path changes. In this interferometer, acousto-optical modulators were used to produce an interfering heterodyne signal between the sample and a nearby surface. To cancel the noise, a differential phase measurement was made between this heterodyne signal and a stable reference heterodyne. DBHI has a stability of 30 picometers over 100ms. We have used this interferometer to measure the ...
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    19. Retinal nerve fiber layer thickness predicts brain atrophy in MS patients

      The thickness of the retinal nerve fiber layer (RNFL), as measured by optical coherence tomography (OCT), correlates with brain atrophy in patients with multiple sclerosis (MS), according to a new report. The thickness of the retinal nerve fiber layer (RNFL), as measured by optical coherence tomography (OCT), correlates with brain atrophy in patients with multiple sclerosis (MS), according to a report in the October 16th issue of Neurology. "This is a promising, inexpensive tool that images CNS nerve fibers," Dr. Peter A. Calabresi from Johns Hopkins School of Medicine, Baltimore, Maryland told Reuters Health. "It may be very useful to ...
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    673-693 of 693 « 1 2 ... 26 27 28 29
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