1. Articles in category: Neurology

    673-696 of 707 « 1 2 ... 26 27 28 29 30 »
    1. Optical coherence Doppler tomography quantifies laser speckle contrast imaging for blood flow imaging in the rat cerebral cortex

      Optical coherence Doppler tomography quantifies laser speckle contrast imaging for blood flow imaging in the rat cerebral cortex

      A dual-imaging modality is demonstrated for high-resolution quantitative imaging of local cerebral blood flow in the rat cortex by combining simultaneous spectral-domain Doppler optical coherence tomography (SDOCT) and full-field laser speckle contrast imaging (LSCI). Preliminary studies in tissue flow phantom and cocaine-induced cerebral blood flow changes indicated that by correlating coregistered cortical arterial blood flow, the relative measurement of flow changes by LSCI could be accurately calibrated by the absolute flow imaging provided by SDOCT (least square fit, r2≈0.96). Quantitative LSCI of cerebral blood flow is crucial to the quantitative analyses of the spatiotemporal hemodynamics of functional brain ...

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    2. Changes in Cellular Structures Revealed by Ultra-high Resolution Retinal Imaging in Optic Neuropathies

      purpose. To study the integrity of inner and outer retinal layers in patients with various types of optic neuropathy by using high-resolution imaging modalities. methods. Three high-resolution imaging systems constructed at the University of California Davis were used to acquire retinal images from patients with optic neuropathy: (1) adaptive optics (AO)-flood–illuminated fundus camera, (2) high-resolution Fourier domain optical coherence tomography (FDOCT), and (3) adaptive optics-Fourier domain optical coherence tomography (AO-FDOCT). The AO fundus camera provides en face images of photoreceptors whereas cross-sectional images (B-scans) of the retina are obtained with both FDOCT and AO-FDOCT. From the volumetric FDOCT ...
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    3. Axonal loss in the retinal nerve fiber layer in patients with multiple sclerosis.

      ObjectiveTo quantify axonal loss in the retinal nerve fiber layer (RNFL) in patients with multiple sclerosis (MS), with and without a history of optic neuritis, by means of ocular imaging technologies. Methods This cross-sectional study enrolled 50 patients with MS and 25 age- and sex-matched healthy controls. All patients underwent neurologic assessment and a complete ophthalmic examination that included visual acuity, visual field examination, optical coherence tomography (OCT), scanning laser polarimetry (GDx) and visual evoked potentials (VEPs). Visual parameters and RNFL measurements were evaluated in MS eyes with a prior optic neuritis episode (MS-ON), with no prior episode (MS-NON) and ...

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    4. Multiple Sclerosis: New multiple sclerosis data have been reported by researchers at University of Houston, College of Optometry

      A new study, 'The relationship between visual field and retinal nerve fiber layer measurements in patients with multiple sclerosis,' is now available. In this recent report, researchers in the United States conducted a study "To investigate the relationship between visual function, measured by standard automated perimetry (SAP), and retinal nerve fiber layer (RNFL) thickness,...
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    5. Inexpensive OCT glaucoma assessment tool can track MS activity

      January 16, 2008, Buffalo, NY--New research by neurologists at the University at Buffalo has shown that optical coherence tomography (OCT) also could be used as a surrogate marker of disease status in multiple sclerosis (MS) and to assess the effectiveness of new and current MS treatments.
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    6. Optic neuritis and multiple sclerosis.

      Related Articles Optic neuritis and multiple sclerosis. Curr Opin Neurol. 2008 Feb;21(1):16-21 Authors: Plant GT PURPOSE OF REVIEW: To discuss recent neuro-ophthalmic advances relevant to the management of optic neuritis and multiple sclerosis. RECENT FINDINGS: Major advances have occurred in the fields of autoimmunity in optic neuritis, and in imaging the retinal nerve fibre layer in both optic neuritis and multiple sclerosis. SUMMARY: A proportion of cases of optic neuritis occur in patients who do not develop multiple sclerosis; the optic neuritis may be monophasic illness or recurrent. In many recurrent cases who also have myelitis (neuromyelitis ...
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    7. Inexpensive Glaucoma Assessment Tool Can Track MS Activity

      University at Buffalo Reporter - New research by neurologists at the University at Buffalo has shown that a technique called optical coherence tomography, or OCT, a simple and inexpensive measure employed currently to assess glaucoma, also could be used as a surrogate marker of ...
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    8. Great Strides Moved MS Research Forward During 2007

      National Multiple Sclerosis Society Published: December 14, 2007 The year 2007 saw rapid research progress in the fields of science and medicine that impact our understanding of the unpredictable neurological disease multiple sclerosis. Thanks to its generous contributors, the National MS Society was able to invest over $46 million this year into over 440 new and ongoing MS research projects as part of its international effort to prevent, treat and cure MS. Significant advances have been made in
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    9. Optical coherence tomography and disease subtype in multiple sclerosis.

      OBJECTIVE: To examine retinal nerve fiber layer (RNFL) thickness, macular volumes (MV), and visual acuity in multiple sclerosis (MS) eyes, with and without history of acute optic neuritis (ON). METHODS: RNFL thickness was measured in 326 MS and 94 control eyes using optical coherence tomography (OCT). MV and vision testing were done in a subset of the cohort. MS subtype was classified as relapsing-remitting (RRMS, n = 135), primary progressive (PPMS, n = 12), and secondary progressive (SPMS, n = 16). RESULTS: MS ON eyes had decreased RNFL thickness (84.2 microm) compared to controls (102.7 microm) (p PMID: 18040015 [PubMed - in ...
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    10. Retinal nerve fiber layer thickness is associated with brain MRI outcomes in multiple sclerosis.

      Multiple sclerosis is characterized by the dual pathological processes of inflammation and neurodegeneration. Conventional MRI techniques are considered the best tools for assessing and monitoring lesion burden and inflammation but are limited in their ability to assess axonal loss. Optical coherence tomography (OCT) is a simple high-resolution technique that uses near infrared light to quantify the thickness of the retinal nerve fiber layer (RNFL), which contains only non-myelinated axons. RNFL thickness (RNFLT) was measured using OCT on thirty consecutive MS patients (60 eyes). Eighteen patients underwent quantitative MRI analysis including T1- and T2-lesion volumes (LV), normalized brain volume (NBV), normalized ...
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    11. Is optical coherence tomography really a new biomarker candidate in multiple sclerosis? A structural and functional evaluation.

      Related Articles Is optical coherence tomography really a new biomarker candidate in multiple sclerosis? A structural and functional evaluation. Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5773-81 Authors: Gundogan FC, Demirkaya S, Sobaci G PURPOSE: To assess the structural and functional status of patients with multiple sclerosis (MS) without a history of optic neuritis. METHODS: Thirty-nine patients with MS who had reported no visual symptoms before and after the time of MS diagnosis were included. Thirty-eight healthy subjects were included as a control group. Retinal nerve fiber layer (RNFL) thickness was determined by optical coherence tomography. Pattern visual evoked ...
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    12. The Relationship between Visual Field and Retinal Nerve Fiber Layer Measurements in Patients with Multiple Sclerosis.

      Related Articles The Relationship between Visual Field and Retinal Nerve Fiber Layer Measurements in Patients with Multiple Sclerosis. Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5798-805 Authors: Cheng H, Laron M, Schiffman JS, Tang RA, Frishman LJ PURPOSE: To investigate the relationship between visual function, measured by standard automated perimetry (SAP), and retinal nerve fiber layer (RNFL) thickness, measured by optical coherence tomography (OCT), in patients with multiple sclerosis (MS). METHODS: SAP and RNFL thickness were measured in patients with MS in 28 eyes with the last optic neuritis (ON) >/=6 months prior (ON group) and 33 eyes without ...
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    13. An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography.

      Related Articles An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography. Brain. 2007 Dec 4; Authors: Henderson AP, Trip SA, Schlottmann PG, Altmann DR, Garway-Heath DF, Plant GT, Miller DH Axonal loss is thought to be the predominant cause of disability in progressive multiple sclerosis (MS). The retinal nerve fibre layer (RNFL) is composed largely of unmyelinated axons of retinal ganglion cells, and is accessible to study with optical coherence tomography (OCT), giving a measure of axonal loss. OCT measures of the RNFL thickness (RNFLT) and macular volume were studied in 23 patients ...
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    14. Optical coherence tomography and disease subtype in multiple sclerosis

      Optical coherence tomography and disease subtype in multiple sclerosis. by multiplesclerosis on Mon 10 Dec 2007 12:00 AM CST | Permanent Link | Cosmos Optical coherence tomography and disease subtype in multiple sclerosis. Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA. OBJECTIVE: To examine retinal nerve fiber layer (RNFL) thickness, macular volumes (MV), and visual acuity in multiple sclerosis (MS) eyes, with and without history of acute optic neu
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    15. An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography

      Axonal loss is thought to be the predominant cause of disability in progressive multiple sclerosis (MS). The retinal nerve fibre layer (RNFL) is composed largely of unmyelinated axons of retinal ganglion cells, and is accessible to study with optical coherence tomography (OCT), giving a measure of axonal loss. OCT measures of the RNFL thickness (RNFLT) and macular volume were studied in 23 patients with primary progressive multiple sclerosis (primary progressive MS) (13 male; 10 female; mean age 52 years; median EDSS 6.0; mean disease duration 11 years), and 27 patients with secondary progressive multiple sclerosis (secondary progressive MS) (8 ...
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    16. The Relationship between Visual Field and Retinal Nerve Fiber Layer Measurements in Patients with Multiple Sclerosis

      purpose. To investigate the relationship between visual function, measured by standard automated perimetry (SAP), and retinal nerve fiber layer (RNFL) thickness, measured by optical coherence tomography (OCT), in patients with multiple sclerosis (MS). methods. SAP and RNFL thickness were measured in patients with MS in 28 eyes with the last optic neuritis (ON) ≥6 months prior (ON group) and 33 eyes without ON history (non-ON group). Abnormal overall or quadrant RNFL thickness was defined by measured values below 5% of the norm. A whole visual field or a sector of the field was classified as abnormal by using cluster criteria ...
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    17. Is Optical Coherence Tomography Really a New Biomarker Candidate in Multiple Sclerosis? A Structural and Functional Evaluation

      purpose. To assess the structural and functional status of patients with multiple sclerosis (MS) without a history of optic neuritis. methods. Thirty-nine patients with MS who had reported no visual symptoms before and after the time of MS diagnosis were included. Thirty-eight healthy subjects were included as a control group. Retinal nerve fiber layer (RNFL) thickness was determined by optical coherence tomography. Pattern visual evoked potentials (PVEP), full-field electroretinogram (ERG), and multifocal electroretinogram (mfERG) were performed. results. There was a significant reduction (P = 0.011) only in temporal RNFL thickness in patients with MS. P100 latency was significantly delayed with ...
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    673-696 of 707 « 1 2 ... 26 27 28 29 30 »
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