1. Articles in category: Neurology

    649-672 of 693 « 1 2 ... 25 26 27 28 29 »
    1. Optical coherence tomography in multiple sclerosis; Thickness of the retinal nerve fiber layer as a potential measure of axonal loss and brain atrophy

      Background Axonal distribution within the retinal nerve fiber layer (RNFL) measured by optical coherence tomography (OCT) correlates with axonal viability and integrity. Objective To investigate correlations between RNFL and MRI measures of axonal loss in MS patients. Methods Fifty one remitting-relapsing MS patients, 20 with a history of optic neuritis (MS-ON), 31 without optic neuritis (MS N-ON), and 12 healthy control subjects (HC) were included in the study. RNFL was measured by OCT and brain atrophy was assessed by MRI. Results The average RNFL in the affected eye (AE) in the MS-ON group was significantly lower than the RNFL in ...
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    2. Retinal atrophy using optical coherence tomography (oct) in 15 patients with multiple sclerosis and comparison with healthy subjects.

      Authors: Jeanjean L, Castelnovo G, Carlander B, Villain M, Mura F, Dupeyron G, Labauge P INTRODUCTION: Multiple sclerosis is a common disabling progressive neurological disorder. Axonal loss is thought to be a likely cause of persistent disability after a multiple sclerosis relapse. Retinal nerve fiber layer (RNFL) imaging by optical coherence tomography (OCT) seems to be a non-invasive way of detecting optical axonal loss following optic neuritis. OBJECTIVE: To determine whether multiple sclerosis affects retinal nerve fiber layer measurements obtained with optical coherence tomography (OCT3-Carl Zeiss Meditec, Dublin, California, USA). MATERIAL AND METHODS: Diagnosis of MS was based on the ...
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    3. OCT imaging has potential as outcome measure for multiple sclerosis

      Researchers have demonstrated that quantifying axon thickness in the retinal nerve fiber layer (RNFL) can be reproducibly measured by trained technicians in a multiple sclerosis center using optical coherence tomography (OCT), according to a study published in the September issue of Archives of Neurology. OCT is a promising new imaging method that has been used predominantly by ophthalmologists to monitor glaucoma. It is being considered as a potential outcome measure in multiple sclerosis (MS)
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    4. Reproducibility of Optical Coherence Tomography in Multiple Sclerosis

      Background  Optical coherence tomography (OCT) is a promising new method of quantifying axon thickness in the retinal nerve fiber layer (RNFL) that has been used predominantly by ophthalmologists to monitor glaucoma. Optical coherence tomography is being considered as a potential outcome measure in multiple sclerosis (MS) clinical trials, but no data exist on the reproducibility of this technique in MS centers.Objective  To determine the reproducibility of OCT measurement of mean RNFL thickness in the undilated eyes of healthy control subjects and patients with MS.Design  Prospective analysis of 4 healthy controls to determine interrater, intrarater, and longitudinal reproducibility. Cross-sectional ...

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    5. Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis

      BackgroundStudying axonal loss in the retina is a promising biomarker for multiple sclerosis (MS). Our aim was to compare optical coherence tomography (OCT) and Heidelberg retinal tomography (HRT) techniques to measure the thickness of the retinal nerve fiber layer (RNFL) in patients with MS, and to explore the relationship between changes in the RNFL thickness with physical and cognitive disability. We studied 52 patients with MS and 18 proportionally matched controls by performing neurological examination, neuropsychological evaluation using the Brief Repetitive Battery-Neuropsychology and RNFL thickness measurement using OCT and HRT.ResultsWe found that both OCT and HRT could define a ...
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    6. Retinal Imaging by Laser Polarimetry and Optical Coherence Tomography Evidence of Axonal Degeneration in Multiple Sclerosis.

      Related Articles Retinal Imaging by Laser Polarimetry and Optical Coherence Tomography Evidence of Axonal Degeneration in Multiple Sclerosis. Arch Neurol. 2008 Jul;65(7):924-928 Authors: Zaveri MS, Conger A, Salter A, Frohman TC, Galetta SL, Markowitz CE, Jacobs DA, Cutter GR, Ying GS, Maguire MG, Calabresi PA, Balcer LJ, Frohman EM BACKGROUND: Optical coherence tomography (OCT) and scanning laser polarimetry with variable corneal compensation (GDx) are similar yet provide information on different aspects of retinal nerve fiber layer (RNFL) structure (thickness values similar to histology for OCT vs birefringence of microtubules for GDx). OBJECTIVES: To compare the ability of ...
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    7. Retinal Imaging by Laser Polarimetry and Optical Coherence Tomography Evidence of Axonal Degeneration in Multiple Sclerosis

      Background Optical coherence tomography (OCT) and scanning laser polarimetry with variable corneal compensation (GDx) are similar yet provide information on different aspects of retinal nerve fiber layer (RNFL) structure (thickness values similar to histology for OCT vs birefringence of microtubules for GDx). Objectives To compare the ability of OCT and GDx to distinguish eyes of patients with multiple sclerosis (MS) from eyes of disease-free controls and thus identify RNFL abnormalities. We also sought to examine the capacity of these techniques to distinguish MS eyes from those without a history of optic neuritis and to correlate with visual function. Design Cross-sectional ...

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    8. Retinal peripapillary nerve fiber layer thickness in neuromyelitis optica.

      Retinal peripapillary nerve fiber layer thickness in neuromyelitis optica. Invest Ophthalmol Vis Sci. 2008 Jul 9; Authors: Merle H, Olindo S, Donnio A, Richer R, Smadja D, Cabre P Purpose: Measure the thickness of retinal peripapillary nerve fibers throughout the course of neuromyelitis optica (NMO). Design: Cross-sectional study. Methods: The thickness of the layer of retinal peripapillary nerve fibers was measured in optical coherence tomography with the Stratus OCT (Optical Coherence Tomography, Carl Zeiss Meditec Inc., Dublin, California, USA), equipped with the 4.0 version of the software. The results were acquired according to protocol with the fast RNFL (Retinal ...
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    9. Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography

      Introduction Optic neuritis causes retinal nerve fiber layer damage, which can be quantified with optical coherence tomography. Optical coherence tomography may be used to track nerve fiber layer changes and to establish a time-dependent relationship between retinal nerve fiber layer thickness and visual function after optic neuritis. Methods This prospective case series included 78 patients with optic neuritis, who underwent optical coherence tomography and visual testing over a mean period of 28 months. The main outcome measures included comparing inter-eye differences in retinal nerve fiber layer thickness between clinically affected and non-affected eyes over time; establishing when RNFL thinning stabilized ...

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    10. Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis.

      Background Studying axonal loss in the retina is a promising biomarker for multiple sclerosis (MS). Our aim was to compare optical coherence tomography (OCT) and Heidelberg retinal tomography (HRT) techniques to measure the thickness of the retinal nerve fiber layer (RNFL) in patients with MS, and to explore the relationship between changes in the RNFL thickness with physical and cognitive disability. We studied 52 patients with MS and 18 proportionally matched controls by performing neurological examination, neuropsychological evaluation using the Brief Repetitive Battery-Neuropsychology and RNFL thickness measurement using OCT and HRT. Results We found that both OCT and HRT could ...
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    11. Optical coherence Doppler tomography quantifies laser speckle contrast imaging for blood flow imaging in the rat cerebral cortex

      Optical coherence Doppler tomography quantifies laser speckle contrast imaging for blood flow imaging in the rat cerebral cortex

      A dual-imaging modality is demonstrated for high-resolution quantitative imaging of local cerebral blood flow in the rat cortex by combining simultaneous spectral-domain Doppler optical coherence tomography (SDOCT) and full-field laser speckle contrast imaging (LSCI). Preliminary studies in tissue flow phantom and cocaine-induced cerebral blood flow changes indicated that by correlating coregistered cortical arterial blood flow, the relative measurement of flow changes by LSCI could be accurately calibrated by the absolute flow imaging provided by SDOCT (least square fit, r2≈0.96). Quantitative LSCI of cerebral blood flow is crucial to the quantitative analyses of the spatiotemporal hemodynamics of functional brain ...

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    12. Changes in Cellular Structures Revealed by Ultra-high Resolution Retinal Imaging in Optic Neuropathies

      purpose. To study the integrity of inner and outer retinal layers in patients with various types of optic neuropathy by using high-resolution imaging modalities. methods. Three high-resolution imaging systems constructed at the University of California Davis were used to acquire retinal images from patients with optic neuropathy: (1) adaptive optics (AO)-flood–illuminated fundus camera, (2) high-resolution Fourier domain optical coherence tomography (FDOCT), and (3) adaptive optics-Fourier domain optical coherence tomography (AO-FDOCT). The AO fundus camera provides en face images of photoreceptors whereas cross-sectional images (B-scans) of the retina are obtained with both FDOCT and AO-FDOCT. From the volumetric FDOCT ...
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    13. Axonal loss in the retinal nerve fiber layer in patients with multiple sclerosis.

      ObjectiveTo quantify axonal loss in the retinal nerve fiber layer (RNFL) in patients with multiple sclerosis (MS), with and without a history of optic neuritis, by means of ocular imaging technologies. Methods This cross-sectional study enrolled 50 patients with MS and 25 age- and sex-matched healthy controls. All patients underwent neurologic assessment and a complete ophthalmic examination that included visual acuity, visual field examination, optical coherence tomography (OCT), scanning laser polarimetry (GDx) and visual evoked potentials (VEPs). Visual parameters and RNFL measurements were evaluated in MS eyes with a prior optic neuritis episode (MS-ON), with no prior episode (MS-NON) and ...

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    14. Multiple Sclerosis: New multiple sclerosis data have been reported by researchers at University of Houston, College of Optometry

      A new study, 'The relationship between visual field and retinal nerve fiber layer measurements in patients with multiple sclerosis,' is now available. In this recent report, researchers in the United States conducted a study "To investigate the relationship between visual function, measured by standard automated perimetry (SAP), and retinal nerve fiber layer (RNFL) thickness,...
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    15. Inexpensive OCT glaucoma assessment tool can track MS activity

      January 16, 2008, Buffalo, NY--New research by neurologists at the University at Buffalo has shown that optical coherence tomography (OCT) also could be used as a surrogate marker of disease status in multiple sclerosis (MS) and to assess the effectiveness of new and current MS treatments.
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    16. Optic neuritis and multiple sclerosis.

      Related Articles Optic neuritis and multiple sclerosis. Curr Opin Neurol. 2008 Feb;21(1):16-21 Authors: Plant GT PURPOSE OF REVIEW: To discuss recent neuro-ophthalmic advances relevant to the management of optic neuritis and multiple sclerosis. RECENT FINDINGS: Major advances have occurred in the fields of autoimmunity in optic neuritis, and in imaging the retinal nerve fibre layer in both optic neuritis and multiple sclerosis. SUMMARY: A proportion of cases of optic neuritis occur in patients who do not develop multiple sclerosis; the optic neuritis may be monophasic illness or recurrent. In many recurrent cases who also have myelitis (neuromyelitis ...
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    17. Inexpensive Glaucoma Assessment Tool Can Track MS Activity

      University at Buffalo Reporter - New research by neurologists at the University at Buffalo has shown that a technique called optical coherence tomography, or OCT, a simple and inexpensive measure employed currently to assess glaucoma, also could be used as a surrogate marker of ...
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    18. Great Strides Moved MS Research Forward During 2007

      National Multiple Sclerosis Society Published: December 14, 2007 The year 2007 saw rapid research progress in the fields of science and medicine that impact our understanding of the unpredictable neurological disease multiple sclerosis. Thanks to its generous contributors, the National MS Society was able to invest over $46 million this year into over 440 new and ongoing MS research projects as part of its international effort to prevent, treat and cure MS. Significant advances have been made in
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    649-672 of 693 « 1 2 ... 25 26 27 28 29 »
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