1. Articles in category: Neurology

    25-48 of 693 « 1 2 3 4 5 ... 27 28 29 »
    1. Ability of swept source OCT to detect retinal changes in patients with bipolar disorder

      Ability of swept source OCT to detect retinal changes in patients with bipolar disorder

      Purpose To evaluate the ability of swept source optical coherence tomography (SS-OCT) to detect retinal changes in patients with bipolar disorder (BD). Methods Twenty-three patients with BD and 23 controls underwent retinal evaluation using SS deep range imaging (DRI) Triton OCT. Full retinal thickness, the ganglion cell layer (GCL), the retinal nerve fiber layer (RNFL), and choroidal thickness were evaluated with automated segmentation software. Results Patients with BD were shown to have significant thinning of the macular full retinal thickness in the center ( p  = 0.049), inner temporal ( p  = 0.045), inner nasal ( p  = 0.016), and inner inferior ( p ...

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    2. Evidence Mounts That an Eye Scan May Detect Early Alzheimer's Disease

      Evidence Mounts That an Eye Scan May Detect Early Alzheimer's Disease

      Results from two studies show that a new, non-invasive imaging device can see signs of Alzheimer's disease in a matter of seconds. The researchers show that the small blood vessels in the retina at the back of the eye are altered in patients with Alzheimer's. Even patients who have a family history of Alzheimer's but have no symptoms show these telltale signs. And they showed that they can distinguish between people with Alzheimer's and those with only mild cognitive impairment. Results from these studies are being presented at AAO 2018, the 122 nd Annual Meeting of ...

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      Mentions: Duke University
    3. Multiple sclerosis: is it all black and white in optical coherence tomography?

      Multiple sclerosis: is it all black and white in optical coherence tomography?

      This scientific commentary refers to ‘Brain and retinal atrophy in African-Americans versus Caucasian-Americans with multiple sclerosis: a longitudinal study’, by Gonzalez Caldito et al. (doi: 10.1093/brain/awy245 ). ... Multiple sclerosis is an inflammatory demyelinating disease of the CNS. Histopathologically, degenerative processes have also been identified early in the disease course and independent of the demyelinating white matter disease. MRI of brain atrophy is currently the gold standard to assess neurodegeneration in vivo . However, longitudinal MRI of brain atrophy is difficult at the individual level owing to great interscan variability. Thus, alternative proxies for neurodegenerative processes that can predict future ...

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    4. Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21

      Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21

      Optical coherence tomography is an optical technique that uses backscattered light to highlight intrinsic structure, and when applied to brain tissue, it can resolve cortical layers and fiber bundles. Optical coherence microscopy (OCM) is higher resolution (i.e., 1.25 µm) and is capable of detecting neurons. In a previous report, we compared the correspondence of OCM acquired imaging of neurons with traditional Nissl stained histology in entorhinal cortex layer II. In the current method-oriented study, we aimed to determine the colocalization success rate between OCM and Nissl in other brain cortical areas with different laminar arrangements and cell packing ...

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    5. Topcon's Harmony imaging platform users in Europe now have access to IDx-DR

      Topcon's Harmony imaging platform users in Europe now have access to IDx-DR

      Topcon Healthcare Solutions (THS) announced today that it has partnered with IDx, a privately held AI diagnostics company, to expand the Harmony imaging platform to include IDx-DR, a state-of-the art AI system that detects diabetic retinopathy in digital fundus images, for its European customers. IDx-DR is the first AI-based diagnostic system with U.S. FDA clearance and a Class IIa CE mark for the autonomous detection of diabetic retinopathy, a complication of diabetes and a leading cause of blindness. In addition to being available as a stand-alone image-analysis solution, IDx-DR is now accessible in Europe via Topcon Harmony , THS’ solution ...

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    6. Multimodal Ocular Imaging in Neurodegeneration

      Multimodal Ocular Imaging in Neurodegeneration

      Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two of the most common types of age-related neurodegenerative disorders. Identifying at-risk patients and gauging disease progression in a non-invasive manner would be invaluable. Early and correct diagnosis is crucial for coordinating supportive care, patient expectations, caregiver arrangements and family planning. In addition, as treatments become available, beginning therapy early in the disease before symptoms become severe will be important. Multimodal ocular imaging (MOI) includes an ophthalmic (eye) exam and eye photographs to evaluate different layers of the retina, which is the light sensing layer of the eye. Newer technologies make ...

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    7. Optical coherence tomography of spontaneous basilar artery dissection in a patient with acute ischemic stroke

      Optical coherence tomography of spontaneous basilar artery dissection in a patient with acute ischemic stroke

      The diagnosis of intracranial arterial dissection (IAD) may be challenging and multimodal imaging techniques are often needed to confirm the diagnosis. Previous studies have based their criteria for diagnosis of IAD on conventional angiography, computed tomography or magnetic resonance imaging. We report a case with acute ischemic stroke due to spontaneous basilar artery dissection in which intravascular optical coherence tomography (OCT) was used to show features of IAD. A 59-year-old woman presented with symptoms of acute ischemic stroke. Thrombosis related to basilar artery (BA) stenosis was assumed on conventional angiography; however, no clot was retrieved after mechanical thrombectomy (MT) and ...

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    8. Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography

      Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography

      Objective: Monitoring hemodynamic and vascular changes in the acute stages of mouse stroke models is invaluable in studying ischemic stroke pathophysiology. However, there lacks a tool to simultaneously and dynamically investigate these changes. Methods: We integrated laser speckle imaging (LSI) and visible-light optical coherence tomography (Vis-OCT) to reveal dynamic vascular responses in acute stages in the distal middle cerebral artery occlusion (dMCAO) model in rodents. LSI provides full-field, real-time imaging to guide Vis-OCT imaging and monitor the dynamic cerebral blood flow (CBF). Vis-OCT offers depth-resolved angiography and oxygen saturation (sO 2 ) measurements. Results: Our results showed detailed CBF and vasculature ...

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    9. Nomogram Using Optical Coherence Tomography and Visual Field Parameters to Predict Brain Lesions in Patients with Bitemporal Hemianopia

      Nomogram Using Optical Coherence Tomography and Visual Field Parameters to Predict Brain Lesions in Patients with Bitemporal Hemianopia

      Purpose : This study aims to develop a nomogram to predict brain lesions in patients with complete or incomplete bitemporal hemianopia by combining results from optical coherence tomography (OCT) and visual field (VF) testing. Material and Methods : We reviewed the medical records of patients who underwent magnetic resonance imaging (MRI) to identify brain lesions due to bitemporal hemianopia between January 2010 and March 2017, retrospectively. The patients were divided into two groups based on MRI findings: brain-lesion (+) group that had brain lesions on MRI ( n = 63), and brain-lesion (-) group without brain lesions on MRI ( n = 16). We compared OCT and VF ...

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    10. First Human Evaluation of Endothelial Healing after a Pipeline Flex Embolization Device with Shield Technology Implanted in Posterior Circulation Using Optical Coherence Tomography

      First Human Evaluation of Endothelial Healing after a Pipeline Flex Embolization Device with Shield Technology Implanted in Posterior Circulation Using Optical Coherence Tomography

      A 64-year-old female presented with an incidentally-discovered right posterior inferior cerebral artery (PICA) aneurysm, initially treated in 2015 by simple coiling. Follow-up demonstrated significant coil compaction that required retreatment. Retreatment was done uneventfully using a Pipeline embolization device (PED) shield deployed starting from the basilar artery and ending at the V4 segment of the vertebral artery. Eight-weeks post-deployment, a follow-up digital subtraction imaging (DSA) and intravascular imaging with optical coherence tomography were obtained. The intravascular imaging demonstrated that the flow diverter had good wall apposition and concentric neointimal growth over the braid with exception to the areas that the PED ...

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      Mentions: St. Jude Medical
    11. Association of Preclinical Alzheimer Disease With Optical Coherence Tomographic Angiography Findings

      Association of Preclinical Alzheimer Disease With Optical Coherence Tomographic Angiography Findings

      Importance Biomarker testing for asymptomatic, preclinical Alzheimer disease (AD) is invasive and expensive. Optical coherence tomographic angiography (OCTA) is a noninvasive technique that allows analysis of retinal and microvascular anatomy, which is altered in early-stage AD. Objective To determine whether OCTA can detect early retinal alterations in cognitively normal study participants with preclinical AD diagnosed by criterion standard biomarker testing. Design, Setting, and Participants This case-control study included 32 participants recruited from the Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St Louis, St Louis, Missouri. Results of extensive neuropsychometric testing determined that all participants were ...

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    12. Correlation between Ciliary Muscle Thickness and Myopia in Saudi Females using Visante Anterior Segment Optical Coherence Tomography

      Correlation between Ciliary Muscle Thickness and Myopia in Saudi Females using Visante Anterior Segment Optical Coherence Tomography

      Purpose: This study was conducted to evaluate the correlation between ciliary muscle thickness and myopia in Saudi females using anterior segment optical coherence tomography (AS-OCT). Subjects and Methods: This study was a prospective, non-randomized, crosssectional, observational, and quantitative study. The study included 65 eyes (33 myopic eyes and 32 non-myopic eyes). All subjects underwent a complete ophthalmic examination, measurement of the refractive error, central corneal curvature (CCC), axial length (AL) and anterior chamber depth (ACD). Ciliary muscle thickness (CMT) at 1 mm, 2mm and 3mm (from the scleral spur) was measured using AS-OCT (Visante; Carl Zeiss). Results: Concerning comparison between ...

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    13. Mapping and Quantitating Penetrating Vessels in Cortical Brain Using Eigen-Decomposition of OCT Signals and Subsequent Principal Component Analysis

      Mapping and Quantitating Penetrating Vessels in Cortical Brain Using Eigen-Decomposition of OCT Signals and Subsequent Principal Component Analysis

      Penetrating vessels bridge the mesh of communicating vessels on the surface of the cortex with the subsurface microvascular beds that feed the underlying neural tissue. Their accurate identification in vivo is important in the investigations of neural degenerative diseases, e.g., Alzheimer's disease and stroke. Here, we propose an efficient method to automatically map cortical penetrating vessels based on an eigen decompensation analysis of the optical coherence tomography (OCT) and OCT angiographic signals. We first project the ensemble of repeated OCT signals into a feature space that represents the power spectral components of eigenvectors through a well-known eigen-decomposition method ...

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    14. Intraoperative Imaging Modalities and the Potential Role of Speckle Modulating Optical Coherence Tomography

      Intraoperative Imaging Modalities and the Potential Role of Speckle Modulating Optical Coherence Tomography

      Maximizing extent of resection has been correlated with improved outcomes in a variety of pediatric and adult brain tumors. 1-11 While gross total resections are often achieved without the use of intraoperative adjuncts, difficulty in distinguishing tumor from normal brain can at times prevent the complete resection of brain tumors. Intraoperative imaging tools have increasingly been embraced with the goal of improving rates of gross total resection. In this review, we will discuss several currently used intraoperative imaging modalities, including intraoperative magnetic resonance imaging (iMRI), wide-field fluorescence, high-resolution fluorescence microscopy, and optical coherence tomography (OCT). 12-17 We will also discuss ...

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    15. Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease

      Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease

      Background: The goal of the present study was to analyze the macular microvacular network in mild cognitive impirment (MCI) and Alzheimer disease (AD). Methods: Twelve patients with AD and 19 patients with MCI were recruited together with 21 cognitively normal controls with a similar range of ages. Optical coherence tomography angiography was used to image the retinal microvascular network at the macular region, including retinal vascular network (RVN), superficial vascular plexus (SVP), and deep vascular plexus (DVP). Fractal analysis (box counting, D box ) representing the microvascular density was performed in different annular zones and quadrantal sectors. The macular ganglion cell ...

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    16. Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis

      Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis

      Topic Optical coherence tomography (OCT) is a non-invasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral domain-OCT (SD-OCT) measurements with Alzheimer’s Disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a systematic review and meta-analysis to examine the SD-OCT measurements in AD and MCI. Clinical Relevance Current methods of diagnosing early AD are expensive and invasive. Retinal measurements of SD-OCT, which are non-invasive, technically simple and inexpensive, are potential biomarkers of AD. Methods We conducted a literature search in PubMed and EMBASE to identify studies published before 31 December 2017 ...

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    17. Detecting Dementia in the Retina

      Detecting Dementia in the Retina

      This retrospective case control explores the retinal features of dementia associated with neurodegenerative diseases, particularly Alzheimer's disease. By linking a pseudonymised dataset of three-dimensional retinal scans, called optical coherence tomography , with nationally held data on dementia, corresponding characteristics will be evaluated through descriptive statistics and machine learning techniques.

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    18. Evaluation of Retinal Thickness in Neurodegenerative Diseases using Spectral Domain Optical Coherence Tomography

      Evaluation of Retinal Thickness in Neurodegenerative Diseases using Spectral Domain Optical Coherence Tomography

      Introduction: Neurodegenerative diseases are characterised by axonal lesions throughout the central nervous system, including the eye with changes in macular thickness and Retinal Nerve Fiber Layer (RNFL) on histopathologic evaluation. Optical coherence tomography facilitates retina as a surrogate measure of neurodegenerative disease activity. Aim: To evaluate macular thickness and retinal nerve fiber layer thickness in patients with neurodegenerative diseases using spectral domain optical coherence tomography (SD-OCT). Materials and Methods: An analytical observational case control study was carried out over a period of two years. Cases consisted of patients (n=20) with neurodegenerative disorders and controls were age and sex matched ...

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    19. Optical coherence tomography as a means to characterize visual pathway involvement in multiple sclerosis

      Optical coherence tomography as a means to characterize visual pathway involvement in multiple sclerosis

      Purpose of review Optical coherence tomography (OCT) is a noninvasive in-vivo imaging tool that enables the quantification of the various retinal layer thicknesses. Given the frequent involvement of the visual pathway in multiple sclerosis , OCT has become an important tool in clinical practice, research and clinical trials. In this review, the role of OCT as a means to investigate visual pathway damage in multiple sclerosis is discussed. Recent findings Evidence from recent OCT studies suggests that the peripapillary retinal nerve fibre layer (pRNFL) appears to be an ideal marker of axonal integrity, whereas the macular ganglion cell and inner plexiform ...

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    20. Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope

      Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope

      We implemented a wide field-of-view visible-light optical coherence microscope (OCM) for investigating ex-vivo brain tissue of patients diagnosed with Alzheimer’s disease (AD) and of a mouse model of AD. A submicrometer axial resolution in tissue was achieved using a broad visible light spectrum. The use of various objective lenses enabled reaching micrometer transversal resolution and the acquisition of images of microscopic brain features, such as cell structures, vessels, and white matter tracts. Amyloid-beta plaques in the range of 10 to 70  μm were visualized. Large field-of-view images of young and old mouse brain sections were imaged using an automated ...

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    21. Deep brain optical coherence tomography angiography in mice: in vivo, noninvasive imaging of hippocampal formation

      Deep brain optical coherence tomography angiography in mice: in vivo, noninvasive imaging of hippocampal formation

      The hippocampus is associated with memory and navigation, and the rodent hippocampus provides a useful model system for studying neurophysiology such as neural plasticity. Vascular changes at this site are closely related to brain diseases, such as Alzheimer’s disease, dementia, and epilepsy. Vascular imaging around the hippocampus in mice may help to further elucidate the mechanisms underlying these diseases. Optical coherence tomography angiography (OCTA) is an emerging technology that can provide label-free blood flow information. As the hippocampus is a deep structure in the mouse brain, direct in vivo visualisation of the vascular network using OCTA and other microscopic ...

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    22. Retinal imaging with optical coherence tomography: a biomarker in multiple sclerosis?

      Retinal imaging with optical coherence tomography: a biomarker in multiple sclerosis?

      Multiple sclerosis (MS) is a progressive neurological disorder characterized by both inflammatory and degenerative components that affect genetically susceptible individuals. Currently, the cause of MS remains unclear, and there is no known cure. Commonly used therapies tend to target inflammatory aspects of MS, but may not halt disease progression, which may be governed by the slow, subclinical accumulation of injury to neuroaxonal structures in the central nervous system (CNS). A recognized challenge in the field of MS relates to the need for better methods of detecting, quantifying, and ameliorating the effects of subclinical disease. Simply stated, better biomarkers are required ...

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    23. Optician's eye test 'could spot early dementia signs'

      Optician's eye test 'could spot early dementia signs'

      A simple eye test carried out by opticians could help predict who is at risk of developing dementia, a study suggests. The test is usually done to spot early signs of eye disease, by looking at tissue at the back of the eye - the retina. Now scientists have found people with thinner retinas are more likely to have problems with memory and reasoning. Researchers believe the test could be used to screen for early dementia. Over 40s health check to include dementia advice The foods that might help with dementia Dementia patients 'abandoned' by system The study of 32,000 ...

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    25-48 of 693 « 1 2 3 4 5 ... 27 28 29 »
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