1. Articles in category: Neurology

    1-24 of 310 1 2 3 4 ... 11 12 13 »
    1. Johns Hopkins University Receives NIH Grant to investigate OCT To Distinguish B/T Tumor & Non-Tumor Tissue in Infiltrating Brain Cancer

      Johns Hopkins University Receives  NIH Grant to investigate OCT To Distinguish B/T Tumor & Non-Tumor Tissue in Infiltrating Brain Cancer

      Johns Hopkins University Receives a 2014 NIH Grant for $47,676 to investigate OCT To Distinguish B/T Tumor & Non-Tumor Tissue in Infiltrating Brain Cancer. The principal investigator is Carmen Kut. The program began in 2014 and ends in 2017. Below is a summary of the proposed work. In brain cancers such as gliomas, aggressive removal of the solid tumor through surgery is associated with improved overall survival. In fact, i has been shown that at least 78% of the tumor has to be removed to make a meaningful difference in the patient's survival. Current techniques for tumor removal ...

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    2. Optical Coherence Tomography angiography reveals laminar microvascular hemodynamics in the rat somatosensory cortex during activation

      Optical Coherence Tomography angiography reveals laminar microvascular hemodynamics in the rat somatosensory cortex during activation

      The BOLD (blood-oxygen-level dependent) fMRI (functional Magnetic Resonance Imaging) signal is shaped, in part, by changes in red blood cell (RBC) content and flow across vascular compartments over time. These complex dynamics have been challenging to characterize directly due to a lack of appropriate imaging modalities. In this study, making use of infrared light scattering from RBCs, depth-resolved Optical Coherence Tomography (OCT) angiography was applied to image laminar functional hyperemia in the rat somatosensory cortex. After defining and validating depth-specific metrics for changes in RBC content and speed, laminar hemodynamic responses in microvasculature up to cortical depths of > 1 mm ...

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    3. Johns Hopkins University Receives a 2014 NIH Grant for 3D Segmentation and Registration of Macular SD-OCT for Applications in Multiple Sclerosis

      Johns Hopkins University Receives a 2014 NIH Grant for 3D Segmentation and Registration of Macular SD-OCT for Applications in Multiple Sclerosis

      Johns Hopkins University Receives a 2014 NIH Grant for $387,284 for 3D Segmentation and Registration of Macular SD-OCT for Applications in Multiple Sclerosis. The principal investigator is Jerry Prince. Below is a summary of the proposed work. Vision is compromised in at least 55% of multiple sclerosis (MS) patients and may represent the very first manifestation of disease onset. Spectral domain optical coherence tomography (SD-OCT) enables in-vivo, high-resolution studies of the retina, and is increasingly being used as a biomarker in neurodegenerative diseases. SD-OCT has provided phenotypical measurements of the retinal nerve fiber layer, ganglion cell layer, and overall ...

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    4. In vivo monitoring of glial scar proliferation on chronically implanted neural electrodes by fiber optical coherence tomography

      In vivo monitoring of glial scar proliferation on chronically implanted neural electrodes by fiber optical coherence tomography

      In neural prosthetics and stereotactic neurosurgery, intracortical electrodes are often utilized for delivering therapeutic electrical pulses, and recording neural electrophysiological signals. Unfortunately, neuroinflammation impairs the neuron-electrode-interface by developing a compact glial encapsulation around the implants in long term. At present, analyzing this immune reaction is only feasible with post-mortem histology; currently no means for specific in vivo monitoring exist and most applicable imaging modalities can not provide information in deep brain regions. Optical coherence tomography (OCT) is a well established imaging modality for in vivo studies, providing cellular resolution and up to 1.2 mm imaging depth in brain tissue ...

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    5. Optical coherence tomography in patients with a history of juvenile multiple sclerosis reveals early retinal damage

      Optical coherence tomography in patients with a history of juvenile multiple sclerosis reveals early retinal damage

      Background and purpose Some 3%−10% of patients with multiple sclerosis (MS) experience disease onset before the age of 18 years (‘early’ onset MS, EOMS). Optical coherence tomography is a non-invasive method to measure retinal nerve fibre layer thickness (RNFLT) and total macular volume (TMV) and may be useful to differentiate axonal and neuronal damage in the retina of patients with a history of EOMS. Here RNFLT and TMV in EOMS patients after a mean disease duration of 11.6 years were compared with patients with age- or disease-duration-matched later onset MS (LOMS) and healthy controls (HCs). Methods In this ...

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    6. SPIE Launches Neurophotonics Journal With Special Section On BRAIN Initiative

      SPIE Launches Neurophotonics Journal With Special Section On BRAIN Initiative

      The new peer-reviewed journal Neurophotonics, published by SPIE, the international society for optics and photonics, will facilitate further collaboration on technological advances in optogenetics, photoacoustics, spectroscopy, and more. This will have significant medical and cognitive applications, and contribute to a comprehensive understanding of the brain. The inaugural issue includes a special section on the the U.S. BRAIN Initiative. The advanced optical methods and applications for imaging and manipulation of the brain that are driving a revolution in the neurosciences were the inspiration behind Neurophotonics, a new peer-reviewed journal published by SPIE, the international society for optics and photonics. The ...

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    7. Retinal Pathology detected by optical coherence tomography in an animal model of Parkinson's disease - Schneider - 2014 - Movement Disorders - Wiley Online Library

      Retinal Pathology detected by optical coherence tomography in an animal model of Parkinson's disease - Schneider - 2014 - Movement Disorders - Wiley Online Library

      Background Optical coherence tomography (OCT) is a noninvasive procedure for analysis of retinal morphology. Significant changes in the thickness of the peripapillary retinal nerve fiber layer (RNFL) in Parkinson's disease (PD) have been reported, and the current study was performed to examine whether such changes can also be detected in an animal model of PD. Methods Optical coherence tomography measurements of peripapillary RNFL thickness, macula volume, and foveal thickness were obtained from 10 normal and five 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated cynomolgus monkeys with stable Parkinsonian signs. Results Average RNFL thickness was significantly decreased in Parkinsonian monkeys compared ...

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    8. To Be or not TB?

      To Be or not TB?

      Relative to other specialties, ophthalmologists deal infrequently with uncertainty. Of course, every patient requires advice, which in turns requires a weighing of risks and benefits, and some pondering of potential unknowns. But unlike internists, ophthalmologists often see the pathology directly. And what once was hidden from us is now rapidly being revealed with new technologies like optical coherence tomography and adaptive optics. Within the ophthalmic kingdom, however, some subspecialties deal with more uncertainty than others. Specialists in uveitis, in particular, often confront uncertainty. Is the pathology autoimmune or infectious? Or even possibly a malignancy like lymphoma? And nothing confounds a ...

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    9. Diagnostic Features of Retinal Nerve Fiber Layer Rotation in Skew Deviation Using Optical Coherence Tomography

      Diagnostic Features of Retinal Nerve Fiber Layer Rotation in Skew Deviation Using Optical Coherence Tomography

      A 41-year-old woman with skew deviation had cyclotorsion of both eyes. This resulted in a falsely low probability plot of retinal nerve fiber layer thickness in adjacent clock hours on optical coherence tomography (OCT) due to displacement of the retinal nerve fiber layer peaks. Ocular cyclotorsion may cause misinterpretation of OCT probability plots. OCT retinal nerve fiber layer plots also may be used to objectively quantify the degree of ocular cyclotorsion.

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      Mentions: Randy H. Kardon
    10. The investigation of acute optic neuritis: a review and proposed protocol

      The investigation of acute optic neuritis: a review and proposed protocol

      Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To date, however, no consensus guidelines have been devised to specify how and when these techniques can be most rationally applied for the diagnostic work-up of patients with acute optic neuritis ...

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    11. Disease course heterogeneity and OCT in multiple sclerosis

      Disease course heterogeneity and OCT in multiple sclerosis

      Background: The heterogeneity of the disease course in multiple sclerosis (MS) remains a challenge for patient management and clinical trials. Objective: The objective of this paper is to investigate the relationship between disease course heterogeneity and retinal layer thicknesses in MS. Methods: A total of 230 MS patients and 63 healthy control subjects were included. Spectral-domain OCT scanning of the peripapillary and macular regions was performed, followed by automated eight-layer segmentation. Generalised estimation equations were used for comparisons. Receiver operating characteristic (ROC) curves were calculated for distinguishing a benign from a typical disease course. Results: Primary progressive patients showed relative ...

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    12. UC Riverside Receives a 2014 NIH Grant for Studying Optical Detection of the Pre-Seizure State

      UC Riverside Receives a 2014 NIH Grant for Studying Optical Detection of the Pre-Seizure State

      UC Riverside Received a 2014 NIH Grant for $437,523 for Studying Optical Detection of the Pre-Seizure State. The principal investigator is Devin Binder. The program began in 2-012 and ends in 2016. Below is a summary of the proposed work. Reliable means of detecting changes which occur during the "pre-seizure state" could serve as a method of seizure prediction, a benchmark in epilepsy research (NIH Curing Epilepsy Conferences, 2000 and 2007). Our preliminary data indicate pre-seizure constriction in brain extracellular space (ECS) accompanied by reduction in near-infrared (NIR) optical scattering prior to detection of seizure by electroencephalography (EEG). The ...

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    13. Correlation Of Visual Field Defects And Optical Coherence tomography Finding in Migraine Patients

      Correlation Of Visual Field Defects And Optical Coherence tomography Finding in Migraine Patients

      Aim of work The aim of our work was to detect any structural or functional visual defects during and in between the attacks in patients with migraine. Patient and methods Sixty patients with migraine as well as sixty age and sex matched controls were included. All cases were subjected to full ophthalmological examination. Cases with any previously known optic nerve abnormalities or with history of increased intraocular pressure were excluded from this study. A full threshold 24-2 automated perimetry as well as optical coherence tomography (OCT) were performed for retinal nerve fiber layer (RNFL) thickness. Correlations between results of study ...

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    14. Evaluation of the chorioretinal thickness changes in Alzheimer's disease using spectral-domain optical coherence tomography

      Evaluation of the chorioretinal thickness changes in Alzheimer's disease using spectral-domain optical coherence tomography

      Background To assess the chorioretinal thickness changes using spectral-domain optical coherence tomography (SD-OCT) and to evaluate the association between these structural changes and cognitive impairment in Alzheimer's disease (AD). Design Prospective, cross-sectional study Participants 31 eyes of 31 consecutive patients with AD and 30 eyes of 30 cognitively healthy age-matched control subjects were recruited Methods SD-OCT (RTVue-100) was used to measure the macular ganglion cell complex thickness (mGCC), outer retinal thickness (ORL), and the choroidal thickness (CT). Cognitive function was evaluated by Mini-Mental State examination (MMSE) on the same day of the optical examination. Main Outcome Measures chorioretinal thickness ...

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    15. Optical Coherence Tomography for Neurosurgery and Cancer Research (Thesis)

      Optical Coherence Tomography for Neurosurgery and Cancer Research (Thesis)

      Optical Coherence Tomography (OCT) provides non-labeling, real-time and high resolution images, which has the potential to transform the paradigm of surgical guidance and preclinical animal studies. The design and development of OCT devices for neurosurgery guidance and novel imaging algorithms for monitoring anti-cancer therapy have been pursued in this work. A forward-imaging needle-type OCT probe was developed which can fit into minimally invasive tools (I.D. ~ 1mm), detect the at-risk blood vessels, and identify tissue micro-landmarks. This promising guidance tool improves the safety and the accuracy of needle-based procedures, which are currently performed without imaging feedback. Despite the great imaging ...

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    16. Cross-validation of serial optical coherence scanning and diffusion tensor imaging: A study on neural fiber maps in human medulla oblongata

      Cross-validation of serial optical coherence scanning and diffusion tensor imaging: A study on neural fiber maps in human medulla oblongata

      We established a strategy to perform cross-validation of serial optical coherence scanner imaging (SOCS) and diffusion tensor imaging (DTI) on a postmortem human medulla. Following DTI, the sample was serially scanned by SOCS, which integrates a vibratome slicer and a multi-contrast optical coherence tomography rig for large-scale three-dimensional imaging at microscopic resolution. The DTI dataset was registered to the SOCS space. An average correlation coefficient of 0.9 was found between the co-registered fiber maps constructed by fractional anisotropy and retardance contrasts. Pixelwise comparison of fiber orientations demonstrated good agreement between the DTI and SOCS measures. Details of the comparison ...

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    17. Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

      Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria

      Background: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research. Objective: An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials. Methods: A prospective multi-centre ( n = 13) study. Peripapillary ring scan QC rating of an OCT training set ( n = 50) was followed by a test set ( n = 50). Inter-rater agreement was calculated using kappa statistics. Results were ...

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    18. Analysis of macular OCT images using deformable registration

      Analysis of macular OCT images using deformable registration

      Optical coherence tomography (OCT) of the macula has become increasingly important in the investigation of retinal pathology. However, deformable image registration, which is used for aligning subjects for pairwise comparisons, population averaging, and atlas label transfer, has not been well–developed and demonstrated on OCT images. In this paper, we present a deformable image registration approach designed specifically for macular OCT images. The approach begins with an initial translation to align the fovea of each subject, followed by a linear rescaling to align the top and bottom retinal boundaries. Finally, the layers within the retina are aligned by a deformable ...

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    19. Optical Coherence Tomography: New Evidence Lends Support for MS Diagnosis

      Optical Coherence Tomography: New Evidence Lends Support for MS Diagnosis

      By measuring retinal thinning, optical coherence tomography (OCT) provides an inexpensive and noninvasive means of assessing CNS pathology in people with MS. Two new studies show that OCT findings correlate with spinal cord and cortical MRI measures. Over the past 30 years, magnetic resonance imaging (MRI) has emerged as a primary tool for diagnosing multiple sclerosis (MS). More recently, a new kid on the block, optical coherence tomography (OCT), has been gaining recognition as a cheaper and less invasive means of assessing pathology in the central nervous system (CNS) of MS patients. In two presentations at the American Academy of ...

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    20. Application of Wide-Field Optical Coherence Tomography to Monitoring of Viability of Rat Brain In Vivo

      Application of Wide-Field Optical Coherence Tomography to Monitoring of Viability of Rat Brain In Vivo

      We investigated the feasibility of OCT in monitoring the viability of the brain. It was confirmed that after an overdose of pentobarbital sodium salt for an euthanasia, the OCT signal intensity increased before cardiac arrest and finally became 2.7 times, and by periodically changing the tissue temperature from 20 to 32 ℃ in vivo, average correlation coefficients between the ratio of signal intensity (RSI) and temperature were determined to be -0.42 to -0.50. RSI reversibly changed with subsequent variations of temperatures and finally increased rapidly just before cardiac arrest. These results indicate that RSI could correspond to decreases ...

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    21. Retinal nerve fibre layer thickness correlates with brain white matter damage in multiple sclerosis: A combined optical coherence tomography and diffusion tensor imaging study

      Retinal nerve fibre layer thickness correlates with brain white matter damage in multiple sclerosis: A combined optical coherence tomography and diffusion tensor imaging study

      We investigated the association of retinal nerve fibre layer thickness (RNFL) with white matter damage assessed by diffusion tensor imaging (DTI). Forty-four MS patients and 30 healthy subjects underwent optical coherence tomography. DTI was analysed with a voxel-based whole brain and region-based analysis of optic radiation, corpus callosum and further white matter. Correlations between RNFL, fractional anisotropy (FA) and other DTI-based parameters were assessed in patients and controls. RNFL correlated with optic radiation FA, but also with corpus callosum and remaining white matter FA. Our findings demonstrate that RNFL changes indicate white matter damage exceeding the visual pathway.

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    22. Retinal alterations in mild cognitive impairment and Alzheimer's disease: an optical coherence tomography study

      Retinal alterations in mild cognitive impairment and Alzheimer's disease: an optical coherence tomography study

      Retinal nerve fiber layer thickness (RNFL) measured by means of Optical Coherence Tomography (OCT) has been used as a marker not only of ophthalmologic diseases but also of neurodegenerative diseases such as Alzheimer’s disease (AD) and mild cognitive impairment (MCI). The purpose of this work was to demonstrate that patients with amnestic MCI show an intermediate RNFL thickness between normality and AD, and a macular volume and thickness as well. In a cross-sectional study we consecutively recruited 18 patients with AD, 21 with MCI, and 41 healthy controls. OCT was performed in all of them to measure circumpapillary RNFL ...

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    23. Current and future potential of retinal optical coherence tomography in multiple sclerosis with and without optic neuritis

      Current and future potential of retinal optical coherence tomography in multiple sclerosis with and without optic neuritis

      Multiple sclerosis (MS) is a disorder characterized by inflammation and neuroaxonal degeneration. The latter is held responsible for the irreversible disability in patients with MS. The eye is a unique window into the brain. With the advent of optical coherence tomography, accurate quantification of retinal layer thickness has become feasible. Neuroaxonal degeneration affecting the retinal layers is structurally and functionally related to pathology in the visual pathways, which is most severe following MS optic neuritis. This is relevant to recognize because MS optic neuritis may mask the subtle thinning of retinal layers associated with global CNS atrophy, which is also ...

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