Neurology -Optical Coherence Tomography News

Articles in category: Neurology

1-24 of 282 1 2 3 4 ... 10 11 12 »
1. Application of an OCT data-based mathematical model of the foveal pit in Parkinson disease
  
  Explore Home - Springer Apr 22 2014 Neurology , Ophthalmology
  
  Spectral-domain Optical coherence tomography (OCT) has shown remarkable utility in the study of retinal disease and has helped to characterize the fovea in Parkinson disease (PD) patients. We developed a detailed mathematical model based on raw OCT data to allow differentiation of foveae of PD patients from healthy controls. Of the various models we tested, a difference of a Gaussian and a polynomial was found to have "the best fit". Decision was based on mathematical evaluation of the fit of the model to the data of 45 control eyes versus 50 PD eyes. We compared the model parameters in the ...
  Read Full Article
  
  Comment
  
  Mentions: Zeiss Cirrus HD-OCT Zeiss Stratus OCT
2. Potential new diagnostic tool for Alzheimer's disease using a linear discriminant function for Fourier domain optical coherence tomography
  
  Explore iovs.org Apr 17 2014 Neurology , Ophthalmology
  
  Purpose: To calculate and validate a linear discriminant function (LDF) for Fourier domain optical coherence tomography (OCT) to improve the diagnostic ability of retinal and retinal nerve fiber layer (RNFL) thickness parameters in the detection of Alzheimer's disease (AD). Method: AD patients (n=151) and age-matched, healthy subjects (n=61) were enrolled. The Cirrus and Spectralis OCT systems were used to obtain retinal measurements and circumpapillary RNFL thickness for each participant. A LDF was calculated using all retinal and RNFL OCT measurements. Receiver operating characteristic (ROC) curves were plotted and compared among the LDF and the standard parameters provided ...
  Read Full Article
  
  Comment
  
  Mentions: Miguel Servet University Hospital Zeiss Cirrus HD-OCT José M. Larrosa
3. Optical coherence tomography and visual evoked potentials in healthy persons
  
  Explore Clinical Neurophysiology Apr 12 2014 Neurology , Ophthalmology
  
  Purpose Optical coherence tomography (OCT) and Visual evoked potentials (VEPs) represent non-invasive objective examination of the visual system. While the OCT measures a morphological property of the retina (thickness of the retinal nerve fibre layer – RNFL), the VEP allows assessment a function of the visual system. There are numerous studies describing a mutual involvement of both mentioned aspects in diseases like multiple sclerosis, optic neuritis or glaucoma, however, normative studies of these relationship are missing. In our study we address this issue with an expectation to translate the findings into interpretation of pathological findings. Methods We examined a group of ...
  Read Full Article
  
  Comment
  
  Mentions: Heidelberg Engineering Heidelberg Spectralis
4. Potential Applications of Spectral-Domain Optical Coherence Tomography (SD-OCT) in the Study of Alzheimer’s Disease
  
  Explore singhealthacademy.edu.sg Apr 1 2014 Neurology , Ophthalmology
  
  Alzheimer’s Disease (AD) is the most common subtype of dementia. As the prevalence of dementia is projected to increase, the burden of the disease on society is expected to become increasingly significant. The link between eye pathology and neurodegenerative diseases has been established in multiple studies. In particular, optic nerve parameters associated with neuronal loss in AD include retinal ganglion cells (RGC). Retinal ganglion cells are similar to neurons in the cerebral cortex, and have been correlated to neurodegeneration in AD. Ocular imaging techniques such as optical coherence tomography (OCT) have provided a rapid and non-invasive method for quantifying ...
  Read Full Article
  
  Comment
  
  Mentions: Singapore Eye Research Institute National University of Singapore
5. Update on Susac Syndrome: New Insights in Brain and Retinal Imaging and Treatment Options
  
  Explore IOS Press Mar 31 2014 Neurology
  
  Susac syndrome (SuS) is a rare endotheliopathy of the brain, the retina, and the inner ear. The underlying pathophysiology is likely an autoimmune mediated occlusion of microvessels resulting in variable degrees of central nervous system (CNS) dysfunction, visual disturbances, and hearing loss. The disease manifests either with a monophasic or polycyclic course. Patients suffering from SuS are frequently misdiagnosed as having inflammatory demyelinating CNS disease, particularly multiple sclerosis because of some overlap in the clinical presentation and the paraclinical findings. Since appropriate treatment of SuS is crucial for the prognosis, a timely and sound establishment of the diagnosis is important ...
  Read Full Article
  
  Comment
6. Assessment of Optic Nerve Head Drusen Using Enhanced Depth Imaging and Swept Source Optical Coherence Tomography
  
  Explore LWW Online Mar 31 2014 Neurology , Ophthalmology
  
  Background: Optic nerve head drusen (ONHD) are calcific deposits buried or at the surface of the optic disc. Although ONHD may be associated with progressive visual field defects, the mechanism of drusen-related field loss is poorly understood. Methods for detecting and imaging disc drusen include B-scan ultrasonography, fundus autofluorescence, and optical coherence tomography (OCT). These modalities are useful for drusen detection but are limited by low resolution or poor penetration of deep structures. This review was designed to assess the potential role of new OCT technologies in imaging ONHD. Evidence Acquisition: Critical appraisal of published literature and comparison of new ...
  Read Full Article
  
  Comment
  
  Mentions: UCSD Robert N. Weinreb Felipe A. Medeiros
7. Neuro-ophthalmology Question of the Week: Optical Coherence Tomography & Optic Nerve Disease
  
  Explore Ophthalmology Mar 25 2014 Neurology , Ophthalmology
  
  Question: In which of the following conditions is subretinal fluid seen on optical coherence tomography (OCT)? 1. Papilledema 2. Non-arteritic ischemic optic neuropathy 3. Diabetic papillopathy 4. Papillitis
  Read Full Article
  
  Comment
  
  Mentions: Stanford University
8. Reliability and validity of Cirrus and Spectralis optical coherence tomography for detecting retinal atrophy in Alzheimer’s disease
  
  Explore Nature Publishing Group Mar 14 2014 Neurology , Ophthalmology
  
  Background To evaluate and compare the ability of two Fourier-domain optical coherence tomography (OCT) devices to detect retinal and retinal nerve fibre layer (RNFL) atrophy in patients with Alzheimer’s disease (AD) compared with healthy subjects; to test the intra-session reliability of two OCT devices in AD patients and healthy subjects. Methods AD patients (n = 75) and age-matched healthy subjects (n = 75) underwent three Macular Cube 200 × 200 protocols using the Cirrus and Spectralis OCT devices and three 360° circular scans centred on the optic disc using the Cirrus OCT device, the classic glaucoma application, and the new Nsite Axonal ...
  Read Full Article
  
  Comment
  
  Mentions: Heidelberg Engineering Carl Zeiss Meditec Miguel Servet University Hospital
9. Stimulated penetrating keratoplasty using real-time virtual intraoperative surgical optical coherence tomography
  
  Explore SPIE | Journal Mar 10 2014 Neurology , Ophthalmology
  
  An intraoperative surgical microscope is an essential tool in a neuro- or ophthalmological surgical environment. Yet, it has an inherent limitation to classify subsurface information because it only provides the surface images. To compensate for and assist in this problem, combining the surgical microscope with optical coherence tomography (OCT) has been adapted. We developed a real-time virtual intraoperative surgical OCT (VISOCT) system by adapting a spectral-domain OCT scanner with a commercial surgical microscope. Thanks to our custom-made beam splitting and image display subsystems, the OCT images and microscopic images are simultaneously visualized through an ocular lens or the eyepiece of ...
  Read Full Article
  
  Comment
  
  Mentions: University of Ulsan Jeehyun Kim Changho Lee
10. Detection of retinal nerve fiber layer degeneration in patients with Alzheimer's disease using optical coherence tomography: searching new biomarker
  
  Explore Wiley Online Library Mar 8 2014 Neurology , Ophthalmology
  
  Letter to the Editor.
  Read Full Article
  
  Comment
  
  Mentions: Miguel Servet University Hospital Luis E. Pablo
11. Optical coherence tomography and visual evoked potentials: which is more sensitive in multiple sclerosis?
  
  Explore Multiple Sclerosis Mar 3 2014 Neurology , Ophthalmology
  
  Objective: To assess the sensitivity of optic coherence tomography (OCT) and visual evoked potentials (VEPs) to visual pathway abnormalities in multiple sclerosis (MS). Methods: A total of 40 MS subjects, 28 with optic neuritis (ON) at least 3 months before (bilateral in 5), underwent assessment of visual acuity, Expanded Disability Status Scale (EDSS), OCT and VEPs, the latter quantified with a 0–4 conventional score. Results: OCT and VEPs were abnormal in 36% and 56% respectively in all eyes ( p =0.11), 68% and 86% in eyes with previous ON ( p =0.12), and in 19% versus 40% in eyes ...
  Read Full Article
  
  Comment
  
  Mentions: San Raffaele Scientfic Institute
12. Choroidal Thinning as a New Finding in Alzheimer's Disease: Evidence from Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography
  
  Explore IOS Press Mar 1 2014 Neurology , Ophthalmology
  
  Background: The involvement of retina and its vasculature has been recently described in Alzheimer's disease (AD). However, none of the previous works have yet investigated the choroid in vivo. Objective: Spectral domain optical coherence tomography (SD-OCT) and enhanced depth imaging (EDI) technique is non-invasively used to assess choroidal thickness in patients with AD and to determine whether the peripapillary retinal nerve fiber layer (RNFL) and central retinal thickness are reduced compared to normal subjects. Methods: Forty-two eyes of 21 patients (mean age, 73.1 ± 6.9 years) with a diagnosis of mild to moderate AD and 42 eyes of ...
  Read Full Article
  
  Comment
  
  Mentions: Sapienza University of Rome
13. A Bibliometric Analysis of Optic Coherence Tomography Studies in Multiple Sclerosis
  
  Explore OMICS Group Feb 27 2014 Neurology , Ophthalmology
  
  igh-resolution cross-sectional images of the retina that has been used for ten years in multiple sclerosis (MS) related optic neuropathies. The objective of this study is to determine the scientific output in use of OCT in multiple sclerosis between 1982 and 2012 using ISI Web of Knowledge. Methods: The ISI Web of Knowledge was searched for articles on OCT published between 1982 and February 2012 using appropriate terms. Articles were characterized each year by publication type. Results: Search yielded 154 publications after the search for keywords “optical coherence tomography and multiple sclerosis and 167 publications after the search for the ...
  Read Full Article
  
  Comment
14. Enhanced depth imaging optical coherence tomography of the choroid in migraine patients: implications for the association of migraine and glaucoma
  
  Explore BJO Online Feb 26 2014 Neurology , Ophthalmology
  
  Aim To compare the choroidal thickness measurements obtained during the attack period and during the pain-free interval in migraine patients using enhanced depth imaging optical coherence tomography (OCT). Methods 58 eyes of 29 subjects with a diagnosis of migraine with or without aura were enrolled in this observational, cross-sectional study. Two OCT scans were performed for each patient, one during the peak period of the migraine attack and the other during the headache-free interval, using the enhanced depth imaging mode. Choroidal thicknesses were measured at the fovea, at three locations nasal and at three locations temporal to the fovea at ...
  Read Full Article
  
  Comment
15. High-resolution spectral domain-optical coherence tomography in multiple sclerosis, Part II – the total macular volume. The first follow-up study over 2 years
  
  Explore Frontiers Feb 24 2014 Neurology , Ophthalmology
  
  Background: Recent studies investigating the use of optical coherence tomography (OCT) in multiple sclerosis (MS) patients have resulted in wide-ranging and often contradictory outcomes. This is mainly due to the complex etiology and heterogeneity of MS, physiological variations in the retinal nerve fiber layer (RNFL) and/or total macular volume (TMV), and limitations in methodology. It remains to be discovered whether any retinal changes in MS develop continuously or in a stepwise fashion, and whether these changes occur in all or a subset of patients. High-resolution spectral domain-OCT devices (SD-OCT) would be required to detect subtle retinal changes and longitudinal ...
  Read Full Article
  
  Comment
  
  Mentions: Medical University of Vienna University of Heidelberg Ursula Schmidt-Erfurth
16. Angiography and Monitoring of Hemodynamic Signals in the Brain via Optical Coherence Tomography (Thesis)
  
  Explore UWM Digital Commons Feb 20 2014 Neurology , Student Theses
  
  The brain is a complex network of interconnected neurons with each cell functioning as a nonlinear processing unit. Neural responses to stimulus can be described by activity in neurons. While blood flow changes have been associated with neural activity and are critical to brain function, this neurovascular coupling is not well understood. This work presents a technique for neurovascular interrogation, combining optogenetics and optical coherence tomography. Optogenetics is a recently developed neuromodulation technique to control activity in the brain using light with precise spatial neuronal control and high temporal resolution. Using this method, cells act as light-gated ion channels and ...
  Read Full Article
  
  Comment
  
  Mentions: University of Wisconsin
17. Detection of retinal nerve fiber layer defects in Alzheimer‘s disease using SD-OCT
  
  Explore Frontiers Feb 18 2014 Neurology , Ophthalmology
  
  Introduction: To examine the clinical value of spectral-domain optical coherence tomography (Spectralis OCT) to detect retinal nerve fibre layer defects in patients with clinically defined Alzheimer‘s disease (AD). Material and Methods: This cross-sectional study included 22 patients with AD (mean age: 75.9 ± 6.1 years) and 22 healthy age- and sex-matched controls. Neuro-ophthalmologic examinations and a series of high-resolution OCT examinations of the peripapillary retinal nerve fibre layer (RNFL) thickness using the Spectralis 3.5-mm circle scan protocol with ART-Modus and eye tracking were obtained, and compared to age- and sex-matched healthy control subjects. Results: Patients with AD ...
  Read Full Article
  
  Comment
  
  Mentions: Heidelberg Spectralis
18. Quantification of the neurodegenerative status in patients with multiple sclerosis by optical coherence tomography in respect to functional vision (Thesis)
  
  Explore diss.fu-berlin.de Feb 18 2014 Neurology , Ophthalmology , Student Theses
  
  Multiple sclerosis is the most frequent, non-traumatic, neurological disorder in young adults in western countries which leads to chronic impairment. The cause of the immune mediated illness remains elusive. Neither clinical nor paraclinical measures can estimate the disability degree or the course of multiple sclerosis (MS). It is crucial to improve the methods which can be a window to the neurodegenerative status of individuals. Structural investigations of the ZNS by MRI own a key position but discriminate between demyelinisation and axonal damage insufficiently and show a discrepancy between lesion load and clinical symptoms. The axonal degeneration goes in line with ...
  Read Full Article
  
  Comment
19. Optical Coherence Tomography in Parkinson's Disease: Is the Retina a Biomarker?
  
  Explore IOS Press Feb 14 2014 Neurology , Ophthalmology
  
  Visual symptoms are a common feature in patients with Parkinson's disease (PD), and retinal dopamine loss and dysfunctions in foveal vision have been described in PD patients. Because visual hallucination (VH) is a specific feature of PD which is differentiated from other parkinsonian disorders, defective visual information processing from both the central and peripheral pathways is suggested to be the pathophysiological mechanisms of VH in PD. Decreased visual acuity as well as impaired contrast sensitivity and color vision is known to be related to the appearance of VH in PD. However, these functional studies were also affected by cognitive ...
  Read Full Article
  
  Comment
20. Optical coherence tomography: a quantitative tool to screen for papilledema in craniosynostosis
  
  Explore Home - Springer Feb 14 2014 Neurology , Ophthalmology
  
  Purpose Our aim was to evaluate if optical coherence tomography (OCT) can be used as an alternative for fundoscopy to screen for increased intracranial pressure (ICP) in children with craniosynostosis Methods We performed a prospective cohort study at the Dutch Craniofacial Centre. We included 38 patients with nonsyndromic scaphocephaly and Crouzon’s syndrome aged 3–8 years old, in whom we scored complaints suggestive of increased ICP and performed fundoscopy and OCT. Main outcome measures total retinal thickness (TRT) which was measured on 58 OCT scans. Results Forty-three percent of fundoscopies revealed pathologic changes of the papil in at least ...
  Read Full Article
  
  Comment
21. Utilizing Optical Coherence Tomography in Diagnosing a Unique Presentation of Chiasmal Hypoplasia Variant of Septo-Optic Dysplasia
  
  Explore LWW Online Jan 24 2014 Neurology , Ophthalmology
  
  Letter to the Editor
  Read Full Article
  
  Comment
22. Visual Involvement in MS: Optic Neuritis and Optical Coherence Tomography
  
  Explore YouTube Jan 23 2014 Neurology , Ophthalmology
  
  This optic neuritis and optical coherence tomography multiple sclerosis webcast identifies the most current clinical trials, treatment options, and the use of optical coherence tomography in patients with multiple sclerosis. To learn more about the Multiple Sclerosis Virtual Grand Rounds series or to claim CME credit, visit
  Read Full Article
  
  Comment
  
  Mentions: Cleveland Clinic
23. Perspectives of an innovative ophthalmological technology: Optical coherence tomography (OCT) – What should be of interest to the neurologist?
  
  Explore Clinical Neurology and Neurosurgery Jan 1 2014 Neurology , Ophthalmology
  
  Ocular coherence tomography has revolutionised the prospects of measuring the loss of retinal ganglion cells secondary to degenerative diseases and monitoring time-dependent changes of optic disc morphology, since the resolution has been improved considerably and the time required has been reduced. Although the non-invasive technique promises a high inter-session reproducibility, the limitations of retinal imaging and the problems of segmenting of the retinal layers have to be taken into account. While the first studies were limited to single sessions in small groups, further trials will elucidate how the retinal nerve fibre layer (RNFL) is altered in the course of different ...
  Read Full Article
  
  Comment
24. University of Minnesota Receives NIH Grant for Depth-Resolved Optical Imaging of Neural Action Potentials
  
  Explore Optical Coherence Tomography News Dec 31 2013 Neurology , Funding
  
  The University of Minnesota Received a 2013 NIH Grant for $293,971 for Depth-Resolved Optical Imaging of Neural Action Potentials. The principal investigator is Taner Akkin. The program began in 2010 and ends in 2014. Below is a summary of the proposed work. As the development of new methods that directly assess neural activity becomes a pressing need, a variety of optical techniques is being investigated for imaging neural structure and function with high temporal and spatial resolutions. Recently, the emerging technology of spectral-domain optical coherence tomography (OCT) has allowed us to simultaneously detect action potential (AP) related phase changes ...
  Read Full Article
  
  Comment
  
  Mentions: National Institutes of Health University of Minnesota Taner Akkin
1-24 of 282 1 2 3 4 ... 10 11 12 »

Search:
Categories
1. Applications:
  Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
2. Business News:
  Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
3. Technology:
  Broadband Sources, Probes, Tunable Sources, Velocimetry
4. Miscellaneous:
  Jobs & Studentships, Student Theses, Textbooks
Popular Articles
Organizations in the News
People in the News
OCT Companies in the News
1. (1 articles) Heidelberg Engineering
OCT Products in the News