Neurology -Optical Coherence Tomography News

Articles in category: Neurology

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1. Optical Coherence Tomography and Corpus Callosum Index in Cognitive Assessment of Multiple Sclerosis Patients
  
  Explore Caspian Journal of Neurological Sciences Nov 13 2018 Neurology
  
  Background: Multiple Sclerosis (MS) is a neurodegenerative disease of central nervous system. Different approaches have been developed to study MS progression and cognitive dysfunction as the major symptom of the disease. The current study compared Optical Coherence Tomography (OCT) and Corpus Callosum Index (CCI) for the early evaluation of cognitive dysfunction in MS patients. Objectives: The aim of this study is to compare OCT with CCI in early evaluation of cognitive dysfunction in MS patients. Materials & Methods: In this study, a total number of 30 patients with relapsing-remitting MS referring to outpatient clinic of Shafa Hospital (Kerman, Iran) were selected ...
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2. The International Multiple Sclerosis Visual System Consortium: Advancing Visual System Research in Multiple Sclerosis
  
  Explore LWW Online Nov 13 2018 Neurology , Ophthalmology
  
  Background: The International Multiple Sclerosis Visual System Consortium (IMSVISUAL) was formed in November 2014 with the primary goal of improving research, care, and education regarding the role of the visual system in multiple sclerosis (MS) and related disorders. Methods: In this review, we describe the formation, goals, activities, and structure of IMSVISUAL, as well as the relationship of IMSVISUAL with the Americas Committee for Treatment and Research in MS (ACTRIMS). Finally, we provide an overview of the work IMSVISUAL has completed to date, as well as an outline of research projects ongoing under the auspices of IMSVISUAL. Results: IMSVISUAL has ...
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  Mentions: Peter A. Calabresi Johns Hopkins University University College London
3. Peripapillary Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography in Different Clinical Subtypes of Multiple Sclerosis
  
  Explore ScienceDirect Nov 8 2018 Neurology , Ophthalmology
  
  Background Multiple sclerosis (MS) is a chronic inflammatory demyelinating autoimmune disease of the central nervous system (CNS) with axonal degeneration as major determinant of neurological disability. Assessment of unmyelinated retinal nerve fibers using optical coherence tomography (OCT) may be useful for diagnosing the onset and rate of progression of neurodegeneration. Objective To assess the incidence and severity of damage of the peripapillary retinal nerve fiber layer (RNFL) in two different MS subtypes: non-progressive [Prog(-)MS] and progressive [Prog(+)MS]. Methods 48 patients (96 eyes) with MS were included: 13 males, 35 females; aged 22-62 years (mean 38.8; SD ±10 ...
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  Mentions: Topcon Medical Systems
4. Fully automated dual-resolution serial optical coherence tomography aimed at diffusion MRI validation in whole mouse brains
  
  Explore SPIE Digital Library Nov 8 2018 Neurology
  
  An automated dual-resolution serial optical coherence tomography (2R-SOCT) scanner is developed. The serial histology system combines a low-resolution (25 μm / voxel) 3 × OCT with a high-resolution (1.5 μm / voxel) 40 × OCT to acquire whole mouse brains at low resolution and to target specific regions of interest (ROIs) at high resolution. The 40 × ROIs positions are selected either manually by the microscope operator or using an automated ROI positioning selection algorithm. Additionally, a multimodal and multiresolution registration pipeline is developed in order to align the 2R-SOCT data onto diffusion MRI (dMRI) data acquired in the same ex vivo mouse brains ...
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  Mentions: University of Montreal Polytechnique Montreal Frédéric Lesage
5. Feasibility Assessment of Optical Coherence Tomography-Guided Laser Labeling in Middle Cranial Fossa Approach
  
  Explore Iranian Journal of Otorhinolaryngology Nov 8 2018 Neurology
  
  Introduction: Different approaches have been developed to find the position of the internal auditory canal (IAC) in middle cranial fossa approach. A feasibility study was performed to investigate the combination of cone beam computed tomography (CBCT), optical coherence tomography (OCT), and laser ablation to assist a surgeon in a middle cranial fossa approach by outlining the internal auditory canal (IAC). Materials and Methods: A combined OCT laser setup was used to outline the position of IAC on the surface of the petrous bone in cadaveric semi-heads. The position of the hidden structures, such as IAC, was determined in MATLAB software ...
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6. Optical coherence tomography features in brothers with aspartylglucosaminuria
  
  Explore Wiley Online Library Oct 31 2018 Neurology , Ophthalmology
  
  Aspartylglucosaminuria is a lysosomal storage disorder enriched in Finland. We report on a pair of non‐Finnish siblings with aspartylglucosaminuria with autofluorescent inclusion bodies on optical coherence tomography, a finding not previously reported in this disorder. We performed a record review, neurological and neuropsychological evaluation, brain MRI, and optical coherence tomography for each patient. They are compound heterozygous for a 34‐kb deletion and a c.365C>A novel variant of the AGA gene. Autofluorescent inclusion bodies were found on optical coherence tomography in the older, more severely affected brother. We hypothesize the finding represents a noninvasive biomarker of disease ...
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  Mentions: UT Southwestern Medical Center
7. Ability of swept source OCT to detect retinal changes in patients with bipolar disorder
  
  Explore Nature Publishing Group Oct 31 2018 Neurology , Ophthalmology
  
  Purpose To evaluate the ability of swept source optical coherence tomography (SS-OCT) to detect retinal changes in patients with bipolar disorder (BD). Methods Twenty-three patients with BD and 23 controls underwent retinal evaluation using SS deep range imaging (DRI) Triton OCT. Full retinal thickness, the ganglion cell layer (GCL), the retinal nerve fiber layer (RNFL), and choroidal thickness were evaluated with automated segmentation software. Results Patients with BD were shown to have significant thinning of the macular full retinal thickness in the center ( p = 0.049), inner temporal ( p = 0.045), inner nasal ( p = 0.016), and inner inferior ( p ...
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  Mentions: Miguel Servet University Hospital José M. Larrosa Luis E. Pablo
8. Evidence Mounts That an Eye Scan May Detect Early Alzheimer's Disease
  
  Explore PR Newswire Oct 28 2018 Neurology , Ophthalmology
  
  Results from two studies show that a new, non-invasive imaging device can see signs of Alzheimer's disease in a matter of seconds. The researchers show that the small blood vessels in the retina at the back of the eye are altered in patients with Alzheimer's. Even patients who have a family history of Alzheimer's but have no symptoms show these telltale signs. And they showed that they can distinguish between people with Alzheimer's and those with only mild cognitive impairment. Results from these studies are being presented at AAO 2018, the 122 nd Annual Meeting of ...
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  Mentions: Duke University
9. Multiple sclerosis: is it all black and white in optical coherence tomography?
  
  Explore Journals Oct 27 2018 Neurology , Ophthalmology
  
  This scientific commentary refers to ‘Brain and retinal atrophy in African-Americans versus Caucasian-Americans with multiple sclerosis: a longitudinal study’, by Gonzalez Caldito et al. (doi: 10.1093/brain/awy245 ). ... Multiple sclerosis is an inflammatory demyelinating disease of the CNS. Histopathologically, degenerative processes have also been identified early in the disease course and independent of the demyelinating white matter disease. MRI of brain atrophy is currently the gold standard to assess neurodegeneration in vivo . However, longitudinal MRI of brain atrophy is difficult at the individual level owing to great interscan variability. Thus, alternative proxies for neurodegenerative processes that can predict future ...
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  Mentions: Technical University of Munich
10. Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21
  
  Explore Home - Springer Oct 24 2018 Neurology
  
  Optical coherence tomography is an optical technique that uses backscattered light to highlight intrinsic structure, and when applied to brain tissue, it can resolve cortical layers and fiber bundles. Optical coherence microscopy (OCM) is higher resolution (i.e., 1.25 µm) and is capable of detecting neurons. In a previous report, we compared the correspondence of OCM acquired imaging of neurons with traditional Nissl stained histology in entorhinal cortex layer II. In the current method-oriented study, we aimed to determine the colocalization success rate between OCM and Nissl in other brain cortical areas with different laminar arrangements and cell packing ...
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  Mentions: Massachusetts Institute of Technology Massachusetts General Hospital Boston University
11. Topcon's Harmony imaging platform users in Europe now have access to IDx-DR
  
  Explore eyediagnosis.net Oct 24 2018 Neurology , Ophthalmology , Other Business News
  
  Topcon Healthcare Solutions (THS) announced today that it has partnered with IDx, a privately held AI diagnostics company, to expand the Harmony imaging platform to include IDx-DR, a state-of-the art AI system that detects diabetic retinopathy in digital fundus images, for its European customers. IDx-DR is the first AI-based diagnostic system with U.S. FDA clearance and a Class IIa CE mark for the autonomous detection of diabetic retinopathy, a complication of diabetes and a leading cause of blindness. In addition to being available as a stand-alone image-analysis solution, IDx-DR is now accessible in Europe via Topcon Harmony , THS’ solution ...
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  Mentions: Topcon Medical Systems
12. Multimodal Ocular Imaging in Neurodegeneration
  
  Explore Home - ClinicalTrials.gov Oct 8 2018 Neurology , Ophthalmology , Clinical Trials
  
  Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two of the most common types of age-related neurodegenerative disorders. Identifying at-risk patients and gauging disease progression in a non-invasive manner would be invaluable. Early and correct diagnosis is crucial for coordinating supportive care, patient expectations, caregiver arrangements and family planning. In addition, as treatments become available, beginning therapy early in the disease before symptoms become severe will be important. Multimodal ocular imaging (MOI) includes an ophthalmic (eye) exam and eye photographs to evaluate different layers of the retina, which is the light sensing layer of the eye. Newer technologies make ...
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  Mentions: University of Michigan
13. Retinal Nerve Fiber Layer and Peripapillary Capillary Density Reduction Detected Using Optical Coherence Tomography Enface Images and Angiography in Optic Tract Syndrome
  
  Explore LWW Online Oct 2 2018 Neurology , Ophthalmology
  
  In a patient with an optic tract syndrome, we describe the loss of retinal nerve fiber layer and retinal microvasculature using enface and optical coherence tomography angiography image analyses.
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14. Optical coherence tomography of spontaneous basilar artery dissection in a patient with acute ischemic stroke
  
  Explore Frontiers Oct 2 2018 Neurology , Ophthalmology
  
  The diagnosis of intracranial arterial dissection (IAD) may be challenging and multimodal imaging techniques are often needed to confirm the diagnosis. Previous studies have based their criteria for diagnosis of IAD on conventional angiography, computed tomography or magnetic resonance imaging. We report a case with acute ischemic stroke due to spontaneous basilar artery dissection in which intravascular optical coherence tomography (OCT) was used to show features of IAD. A 59-year-old woman presented with symptoms of acute ischemic stroke. Thrombosis related to basilar artery (BA) stenosis was assumed on conventional angiography; however, no clot was retrieved after mechanical thrombectomy (MT) and ...
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  Mentions: Capital Medical University
15. Monitoring Acute Stroke in Mouse Model Using Laser Speckle Imaging-Guided Visible-Light Optical Coherence Tomography
  
  Explore IEEE Xplore Sep 20 2018 Developmental Biology , Neurology
  
  Objective: Monitoring hemodynamic and vascular changes in the acute stages of mouse stroke models is invaluable in studying ischemic stroke pathophysiology. However, there lacks a tool to simultaneously and dynamically investigate these changes. Methods: We integrated laser speckle imaging (LSI) and visible-light optical coherence tomography (Vis-OCT) to reveal dynamic vascular responses in acute stages in the distal middle cerebral artery occlusion (dMCAO) model in rodents. LSI provides full-field, real-time imaging to guide Vis-OCT imaging and monitor the dynamic cerebral blood flow (CBF). Vis-OCT offers depth-resolved angiography and oxygen saturation (sO 2 ) measurements. Results: Our results showed detailed CBF and vasculature ...
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  Mentions: Northwestern University Hao F. Zhang Opticent Health
16. Nomogram Using Optical Coherence Tomography and Visual Field Parameters to Predict Brain Lesions in Patients with Bitemporal Hemianopia
  
  Explore Taylor & Francis Online Sep 16 2018 Neurology , Ophthalmology
  
  Purpose : This study aims to develop a nomogram to predict brain lesions in patients with complete or incomplete bitemporal hemianopia by combining results from optical coherence tomography (OCT) and visual field (VF) testing. Material and Methods : We reviewed the medical records of patients who underwent magnetic resonance imaging (MRI) to identify brain lesions due to bitemporal hemianopia between January 2010 and March 2017, retrospectively. The patients were divided into two groups based on MRI findings: brain-lesion (+) group that had brain lesions on MRI ( n = 63), and brain-lesion (-) group without brain lesions on MRI ( n = 16). We compared OCT and VF ...
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  Mentions: Yonsei University Gong Je Seong Chan Yun Kim
17. First Human Evaluation of Endothelial Healing after a Pipeline Flex Embolization Device with Shield Technology Implanted in Posterior Circulation Using Optical Coherence Tomography
  
  Explore Neurointervention Sep 16 2018 Cardiology , Neurology
  
  A 64-year-old female presented with an incidentally-discovered right posterior inferior cerebral artery (PICA) aneurysm, initially treated in 2015 by simple coiling. Follow-up demonstrated significant coil compaction that required retreatment. Retreatment was done uneventfully using a Pipeline embolization device (PED) shield deployed starting from the basilar artery and ending at the V4 segment of the vertebral artery. Eight-weeks post-deployment, a follow-up digital subtraction imaging (DSA) and intravascular imaging with optical coherence tomography were obtained. The intravascular imaging demonstrated that the flow diverter had good wall apposition and concentric neointimal growth over the braid with exception to the areas that the PED ...
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  Mentions: St. Jude Medical
18. Association of Preclinical Alzheimer Disease With Optical Coherence Tomographic Angiography Findings
  
  Explore The JAMA Network Aug 25 2018 Neurology , Ophthalmology
  
  Importance Biomarker testing for asymptomatic, preclinical Alzheimer disease (AD) is invasive and expensive. Optical coherence tomographic angiography (OCTA) is a noninvasive technique that allows analysis of retinal and microvascular anatomy, which is altered in early-stage AD. Objective To determine whether OCTA can detect early retinal alterations in cognitively normal study participants with preclinical AD diagnosed by criterion standard biomarker testing. Design, Setting, and Participants This case-control study included 32 participants recruited from the Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St Louis, St Louis, Missouri. Results of extensive neuropsychometric testing determined that all participants were ...
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  Mentions: Washington University in St. Louis
19. Correlation between Ciliary Muscle Thickness and Myopia in Saudi Females using Visante Anterior Segment Optical Coherence Tomography
  
  Explore Scient Open Access Aug 23 2018 Neurology , Ophthalmology
  
  Purpose: This study was conducted to evaluate the correlation between ciliary muscle thickness and myopia in Saudi females using anterior segment optical coherence tomography (AS-OCT). Subjects and Methods: This study was a prospective, non-randomized, crosssectional, observational, and quantitative study. The study included 65 eyes (33 myopic eyes and 32 non-myopic eyes). All subjects underwent a complete ophthalmic examination, measurement of the refractive error, central corneal curvature (CCC), axial length (AL) and anterior chamber depth (ACD). Ciliary muscle thickness (CMT) at 1 mm, 2mm and 3mm (from the scleral spur) was measured using AS-OCT (Visante; Carl Zeiss). Results: Concerning comparison between ...
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  Mentions: Carl Zeiss Meditec Zeiss Visante OCT
20. Mapping and Quantitating Penetrating Vessels in Cortical Brain Using Eigen-Decomposition of OCT Signals and Subsequent Principal Component Analysis
  
  Explore IEEE Xplore Aug 23 2018 Neurology
  
  Penetrating vessels bridge the mesh of communicating vessels on the surface of the cortex with the subsurface microvascular beds that feed the underlying neural tissue. Their accurate identification in vivo is important in the investigations of neural degenerative diseases, e.g., Alzheimer's disease and stroke. Here, we propose an efficient method to automatically map cortical penetrating vessels based on an eigen decompensation analysis of the optical coherence tomography (OCT) and OCT angiographic signals. We first project the ensemble of repeated OCT signals into a feature space that represents the power spectral components of eigenvectors through a well-known eigen-decomposition method ...
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  Mentions: University of Washington Ruikang K. Wang
21. Intraoperative Imaging Modalities and the Potential Role of Speckle Modulating Optical Coherence Tomography
  
  Explore Journals Aug 21 2018 Neurology , Ophthalmology
  
  Maximizing extent of resection has been correlated with improved outcomes in a variety of pediatric and adult brain tumors. 1-11 While gross total resections are often achieved without the use of intraoperative adjuncts, difficulty in distinguishing tumor from normal brain can at times prevent the complete resection of brain tumors. Intraoperative imaging tools have increasingly been embraced with the goal of improving rates of gross total resection. In this review, we will discuss several currently used intraoperative imaging modalities, including intraoperative magnetic resonance imaging (iMRI), wide-field fluorescence, high-resolution fluorescence microscopy, and optical coherence tomography (OCT). 12-17 We will also discuss ...
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  Mentions: Stanford University Adam de la Zerda Orly Liba
22. Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease
  
  Explore LWW Online Aug 17 2018 Neurology , Ophthalmology
  
  Background: The goal of the present study was to analyze the macular microvacular network in mild cognitive impirment (MCI) and Alzheimer disease (AD). Methods: Twelve patients with AD and 19 patients with MCI were recruited together with 21 cognitively normal controls with a similar range of ages. Optical coherence tomography angiography was used to image the retinal microvascular network at the macular region, including retinal vascular network (RVN), superficial vascular plexus (SVP), and deep vascular plexus (DVP). Fractal analysis (box counting, D box ) representing the microvascular density was performed in different annular zones and quadrantal sectors. The macular ganglion cell ...
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  Mentions: Giovanni Gregori Carl Zeiss Meditec Jianhua Wang
23. Spectral Domain-Optical Coherence Tomography Measurements in Alzheimer’s Disease: A Systematic Review and Meta-analysis
  
  Explore ScienceDirect Aug 16 2018 Neurology , Ophthalmology
  
  Topic Optical coherence tomography (OCT) is a non-invasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral domain-OCT (SD-OCT) measurements with Alzheimer’s Disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a systematic review and meta-analysis to examine the SD-OCT measurements in AD and MCI. Clinical Relevance Current methods of diagnosing early AD are expensive and invasive. Retinal measurements of SD-OCT, which are non-invasive, technically simple and inexpensive, are potential biomarkers of AD. Methods We conducted a literature search in PubMed and EMBASE to identify studies published before 31 December 2017 ...
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  Mentions: Singapore Eye Research Institute National University of Singapore The Chinese University of Hong Kong
24. Detecting Dementia in the Retina
  
  Explore Home - ClinicalTrials.gov Aug 15 2018 Neurology , Clinical Trials
  
  This retrospective case control explores the retinal features of dementia associated with neurodegenerative diseases, particularly Alzheimer's disease. By linking a pseudonymised dataset of three-dimensional retinal scans, called optical coherence tomography , with nationally held data on dementia, corresponding characteristics will be evaluated through descriptive statistics and machine learning techniques.
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  Mentions: University College London
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