Category: Neurology

1. OCT Companies in the News

   (5 articles) Carl Zeiss Meditec

   (4 articles) Heidelberg Engineering

   (1 articles) Thorlabs

   (1 articles) Michelson Diagnostics

2. OCT Products in the News

   (2 articles) Zeiss Stratus OCT

   (2 articles) Zeiss Cirrus HD-OCT

3. Organizations in the News

   (23 articles) Johns Hopkins University

   (10 articles) University of Alabama

   (8 articles) UT Southwestern Medical Center

   (6 articles) State University of New York at Buffalo

   (5 articles) Harvard University

   (5 articles) Jacobs Neurological Institute

   (5 articles) University College London

   (4 articles) Washington University in St. Louis

   (3 articles) University of Houston

   (2 articles) University of Iowa

4. People in the News

   (12 articles) Peter A. Calabresi

   (11 articles) Laura J. Balcer

   (6 articles) Gary Cutter

   (5 articles) Bianca Weinstock-Guttman

   (2 articles) Randy H. Kardon

   (2 articles) John Richert

   (2 articles) Patricia O'Looney

   (1 articles) Yan Wang

   (1 articles) Peter J. Savino

   (1 articles) Denise A. Valenti

1. Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats

   Explore Article ScienceDirect (Mar 14 2010) Neurology , Ophthalmology

   Purpose To obtain three-dimensional images from retinal transplants in live animals and evaluate the placement and structural quality of the transplants. Methods Donor retinal sheets were isolated from E19 fetuses of transgenic rats expressing human alkaline phosphatase (hPAP), and transplanted to the subretinal space of 19–56 days old S334ter-3 rat recipients with fast retinal degeneration (average age at surgery 32 days). A total of 143 rats were imaged 1 day to 2.8 months after surgery, using a Fourier-domain optical coherence tomography (FDOCT) system, with an axial resolution of 3.5 μm. The CCD A-line integration time was set at 200 μs ...
   

   Comment on Article Mentions:   Zhongping Chen   UC Irvine

2. Optical Coherence Tomography - National MS Society (Video)

   Explore Article YouTube (Feb 16 2010) Neurology , Ophthalmology

   MS Learn Online is the National MS Society's online educational webcast series. This video features Peter Calabresi, MD, who talks about OCT, or optical coherence tomography and how it can be used to measure multiple sclerosis.
   

   Comment on Article

3. Interweaving neurology and ophthalmology

   Explore Article TheLancet.com (Feb 15 2010) Neurology , Ophthalmology

   Neuro-ophthalmology—a subspecialty at the intersection of ophthalmology, neurology, neurosurgery, and general medicine—deals with ocular diseases as well as myriad neurological and systemic conditions with ophthalmic manifestations. More than ever before, successful practice of neuro-ophthalmology requires both careful clinical observation (aided by familiar tools such as slit-lamp microscopes and stereoscopic ophthalmoscopes) and use of increasingly sophisticated technologies, such as neuroradiological imaging and optical coherence tomography. New tools will never replace the need for clinical acumen, but they are helping to transform aspects of neuro-ophthalmology.
   

   Comment on Article

4. A preliminary longitudinal study of the retinal nerve fiber layer in progressive multiple sclerosis

   Explore Article SpringerLink Home (Feb 8 2010) Neurology

   Abstract  Thinning of the retinal nerve fiber layer (RNFL) of clinically unaffected eyes is seen in patients with multiple sclerosis (MS). It is uncertain when this thinning occurs, and whether ongoing RNFL loss can be measured over time with optical coherence tomography (OCT). Using time-domain OCT, we studied 34 patients with progressive MS (16 primary progressive MS, 18 secondary progressive; 14 male; 20 female; mean age at study entry 51 years; median EDSS 6; mean disease duration at study entry 12 years) on two occasions with a median interval of 575 (range 411–895) days apart. Eighteen healthy controls (10 male; eight female; mean ...
   

   Comment on Article Mentions:   University College London

5. A new window in multiple sclerosis pathology: non-conventional quantitative magnetic resonance imaging outcomes

   Explore Article ScienceDirect (Jan 29 2010) Neurology

   Recent findings suggest that neuronal pathology occurs early in the course of multiple sclerosis and seems to be responsible for accumulation of disability. Nonetheless, the nervous system has an intrinsic potential for repair and compensation in the neuronal component. Disease-modifying drugs such as glatiramer acetate interfere with, and down-regulate, inflammatory pathology and slow neurodegeneration. Moreover, certain regulatory cytokines and neurotrophic factors have the capacity to promote neuronal and axonal repair. Given the importance of neuronal injury in multiple sclerosis and the potential of certain treatments for neuronal repair, it is important to possess adequate and sensitive tools to visualise the ...
   

   Comment on Article

6. The Use of Optical Coherence Tomography in Neurology

   Explore Article MedReviews (Jan 13 2010) Neurology

   Optical coherence tomography (OCT) is a noninvasive imaging technique routinely used in ophthalmology to visualize and quantify the layers of the retina. OCT allows direct visualization and measurement of the topography of the optic nerve head and retinal nerve fiber layer thickness in the peripapillary and macular regions with micron-scale resolution. These measurements are of particular interest in optic neuropathies and in numerous neurologic disorders in which there is axonal loss, such as multiple sclerosis. This article provides a detailed overview of OCT and its potential applications in neurology.
   

   Comment on Article

7. Announcement of Michelson-Diagnostics OCT-News Student Travel Grant Winner

   Explore Article Optical Coherence Tomography News (Jan 6 2010) Neurology

   On November 4th OCT News in partnership with Michelson Diagnostics and funded by a generous donation from Michelson Diagnostics, announced a $1,500 student travel grant opportunity. We received numerous submissions all of which displayed outstanding work. The awards were ranked by OCT News, Michelso
   

   Comment on Article Mentions:   B. Hyle Park   Yan Wang   UC Riverside

8. Rapid volumetric angiography of cortical microvasculature with optical coherence tomography

   Explore Article opticsinfobase.org (Dec 23 2009) Neurology

   We describe methods and algorithms for rapid volumetric imaging of cortical vasculature with optical coherence tomography (OCT). By optimizing system design, scanning protocols, and algorithms for visualization of capillary flow, comprehensive imaging of the surface pial vasculature and capillary bed is performed in approximately 12 s. By imaging during hypercapnia and comparing with simultaneous CCD imaging, the sources of contrast of OCT angiography are investigated.
   

   Comment on Article Mentions:   Alex E. Cable   Vivek J. Srinivasan   Thorlabs

9. Evaluation of Neural Loss in Multiple Sclerosis and Neuromyelitis Optica Using High Resolution OCT

   Explore Article Home - ClinicalTrials.gov (Dec 2 2009) Neurology , Ophthalmology , Clinical Trials

   Evaluation of Macular and Retinal Nerve Fiber Layer Thickness Measurements for Detection of Neural Loss in Multiple Sclerosis and Neuromyelitis Optica Using High Resolution Optical Coherence Tomography.
   

   Comment on Article Mentions:   University of São Paulo

10. Depth resolved imaging of neural activity by optical coherence tomography (functional OCT)

    Explore Article SPIE Digital Library (Nov 30 2009) Neurology

    We have developed a functional imaging technique based on optical coherence tomography (OCT). This technique resolves 0.01-0.1 mm functional structures along the depth axis. The basis of the technique is that neural activation changes light scattering of the light penetrating the neural tissue due to activity dependent structural changes.
    

    Comment on Article

11. Neurosurgeons can now perform a virtual brain biopsy in real-time without perforating the skull

    Explore Article examiner.com (Nov 13 2009) Microscopy , Neurology , Oncology

    Without actually having to pry open the skull, the hand-held confocal microscope probes the brain by using a technique called optical coherence tomography which allows neurosurgeons to virtually analyze the brain. Finally, the neurosurgeon can probe ...
    

    Comment on Article Mentions:   University of Pittsburgh

12. Macular Volume Determined by Optical Coherence Tomography as a Measure of Neuronal Loss in Multiple Sclerosis

    Explore Article Archives of Neurology, a monthly peer (Nov 9 2009) Neurology , Ophthalmology

    Background  Inner (area adjacent to the fovea) and outer regions of the macula differ with respect to relative thicknesses of the ganglion cell layer (neurons) vs retinal nerve fiber layer (RNFL; axons). Objective  To determine how inner vs outer macular volumes relate to peripapillary RNFL thickness and visual function in multiple sclerosis (MS) and to examine how these patterns differ among eyes with vs without a history of acute optic neuritis (ON). Design  Study using cross-sectional optical coherence tomography. Setting  Three academic tertiary care MS centers. Participants  Patients with MS, diagnosed by standard criteria, and disease-free control participants. Main Outcome ...
    

    Comment on Article Mentions:   UT Southwestern Medical Center   Georgetown University   Laura J. Balcer

13. Optical Coherence Tomography in Clinically Isolated Syndrome: No Evidence of Subclinical Retinal Axonal Loss

    Explore Article Archives of Neurology, a monthly peer (Nov 9 2009) Neurology , Ophthalmology

    Background  Optical coherence tomography has emerged as a new tool for quantifying axonal loss in multiple sclerosis (MS). A reduction in retinal nerve fiber layer (RNFL) thickness is correlated with Expanded Disability Status Scale score and brain atrophy. Objective  To investigate RNFL and macular volume measurements using optical coherence tomography in the clinically isolated syndrome population. Design  Prospective case series. Settings  Neurologic clinics at the university hospitals of Lille and Strasbourg (France). Participants  Fifty-six consecutive patients with clinically isolated syndrome (18 with optic neuritis and 38 without optic neuritis) and 32 control subjects. Main Outcome Measures  Macular volume and RNFL ...
    

    Comment on Article

14. A rat model for studying neural stem cell transplantation

    Explore Article chinaphar.com (Nov 6 2009) Neurology

    Aim:The goal of this project was to develop a rat model for neural stem cell (NSC) transplantation studies in which NSCs were modified with brain-derived neurotrophic factor (BDNF) genes that may permit extensive and reliable analysis of the transplants. Methods: NSCs were cultured and purified by limiting dilution assay in vitro and infected with recombinant retrovirus pLXSN-BDNF (BDNF-NSCs) and retrovirus pLXSN (p-NSCs). The expression of BDNF genes in transgenic and control NSC groups was measured by FQ-PCR and ELISA assays. NSCs were then transplanted into the subretinal space of normal rat retinas in four groups, which included NSCs alone, BDNF-NSCs, ...
    

    Comment on Article Mentions:   Heidelberg Engineering

15. Progressive changes in the retinal nerve fiber layer in patients with multiple sclerosis

    Explore Article eur-j-ophthalmol.com (Nov 3 2009) Neurology , Ophthalmology

    Purpose. To quantify changes in the retinal nerve fiber layer (RNFL) of patients with multiple sclerosis (MS) over a 1-year time period and to compare the ability of noninvasive diagnostic imaging devices and visual evoked potentials (VEP) to detect axonal loss in these patients. Methods. Eighty-one patients with MS underwent a complete ophthalmic examination that included assessment of visual acuity and color vision, refractive evaluation, visual field examination, optical coherence tomography (OCT), scanning laser polarimetry (GDx), and measurement of VEP. All the patients were re-evaluated after a period of 12 months in order to quantify any change in the RNFL. ...
    

    Comment on Article

1-15 of 83 // 1 2 3 4 5 6 »