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Organizations in the News
(27 articles) Johns Hopkins University
(17 articles) UT Southwestern Medical Center
(14 articles) University of Alabama
(6 articles) State University of New York at Buffalo
(6 articles) University College London
(5 articles) Harvard University
(5 articles) Jacobs Neurological Institute
(4 articles) Washington University in St. Louis
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Measurement of signal intensity depth profiles in rat brains with cardiac arrest maintaining primary temperature by wide-field optical coherence tomography
Explore Article opticsinfobase.org (Aug 31 2010)
We have already reported that after an injection for euthanasia, the signal intensity of optical coherence tomography (OCT) images are 2.7 times increased before cardiac arrest (CA) using OCT and rat brains without temperature control to show the potential of OCT to monitor tissue viability in brains [Appl. Opt. 48, 4354 (2009)]. In this paper, we similarly measured maintaining the primary temperature of rat brains. It was confirmed that when maintaining the primary temperature, the time courses of the ratios of signal intensity (RSIs) were almost the same as those without temperature control. RSIs after CA varied from 1.6 to ...
Comment on Article Mentions: Manabu Sato Yamagata University
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A serial study of retinal changes following optic neuritis with sample size estimates for acute neuroprotection trials
Explore Article Oxford Journals (Aug 27 2010)
Following an episode of optic neuritis, thinning of the retinal nerve fibre layer, which indicates axonal loss, is observed using optical coherence tomography. The longitudinal course of the retinal changes has not been well characterized. We performed a serial optical coherence tomography study in patients presenting with optic neuritis in order to define the temporal evolution of retinal nerve fibre layer changes and to estimate sample sizes for proof-of-concept trials of neuroprotection using retinal nerve fibre layer loss as the outcome measure. Twenty-three patients (7 male, 16 female, mean age 31 years) with acute clinically isolated unilateral optic neuritis were ...
Comment on Article Mentions: University College London
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Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis
Explore Article TheLancet.com (Aug 16 2010)
Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre layer (RNFL). Meta-analyses of data for time domain OCT show RNFL thinning of 20·38 μm (95% CI 17·91—22·86, n=2063, p<0·0001) after optic neuritis in MS, and of 7·08 μm (5·52—8·65, n=3154, p<0·0001) in MS without optic neuritis. The estimated RNFL thinning in patients with MS is greater than the extent expected in normal ageing, probably because of retrograde trans-synaptic degeneration and progressive loss of retinal ganglion cells, in addition to the more pronounced thinning ...
Comment on Article Mentions: Johannes F. de Boer Peter A. Calabresi Johns Hopkins University
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Reproducibility of high-resolution optical coherence tomography in multiple sclerosis
Explore Article Multiple Sclerosis (Jun 9 2010)
Optical coherence tomography (OCT) is a non-invasive method to quantify neurodegeneration as an outcome in multiple sclerosis clinical trials; however, no data exist on Cirrus spectral domain optical coherence tomography (SD-OCT) reproducibility in patients with multiple sclerosis. The objective of this study was to determine the protocol for achieving optimal inter-visit, inter-rater, and intra-rater reproducibility for studies performed on healthy controls and multiple sclerosis patients utilizing novel high-definition SD-OCT. This is a prospective study of inter-visit, inter-rater, and intra-rater reproducibility in multiple sclerosis patients (n = 58) and healthy controls (n = 32) on Cirrus-HD SD-OCT. Excellent reproducibility of average ...
Comment on Article Mentions: Peter A. Calabresi Johns Hopkins University University of Alabama
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Simple Eye Test Measures Damage from Multiple Sclerosis
Explore Article Newswise (Jun 7 2010)
A quick, painless eye measurement shows promise as a way to diagnose multiple sclerosis in its very early stages, and to track the effectiveness of treatments, researchers from UT Southwestern Medical Center have found in a multicenter study. “This technique has the potential to provide a powerful and reliable assessment strategy to measure structural changes in the central nervous system, both for diagnostic purposes and in clinical trials to monitor whether potential treatments can prevent deterioration or restore nerve function,” said Dr. Elliot Frohman, professor of neurology and ophthalmology, director of the Multiple Sclerosis Clinical Center at UT Southwestern and ...
Comment on Article Mentions: UT Southwestern Medical Center University of Alabama National Institutes of Health
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Comparison of Optical Coherence Tomography and Scanning Laser Polarimetry Measurements in Patients with Multiple Sclerosis
Explore Article LWW Online (May 21 2010)
Purpose. To compare optical coherence tomography (OCT) and scanning laser polarimetry (GDx) measurements of the retinal nerve fiber layer (RNFL) in multiple sclerosis (MS) patients with and without optic neuritis (ON). Methods. OCT and GDx were performed on 68 MS patients. Qualifying eyes were divided into two groups: 51 eyes with an ON history >=6 months before (ON eyes) and 65 eyes with no history of ON (non-ON eyes). Several GDx and OCT parameters and criteria were used to define an eye as abnormal, for example, GDx nerve fiber indicator (NFI) >20 or 30, OCT average RNFL thickness, and GDx ...
Comment on Article Mentions: University of Houston Han Cheng
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Fiber spectral domain optical coherence tomography for in vivo rat brain imaging
Explore Article SPIE Digital Library (May 18 2010)
A well established navigation method is one of the key conditions for successful brain surgery: It should be accurate, safe and online operable. Recent research shows that Optical Coherence Tomography is a potential solution for this application by providing a high resolution and small probe dimension. In this study a fiber Spectral-Domain OCT system with a super luminescent diode with the center wavelength of 840 nm providing 13.6 µm axial resolution was used. A single mode fiber (Ø 125 µm) was employed as the detecting probe. The information acquired by OCT was reconstructed into grayscale images by vertically aligning several ...
Comment on Article Mentions: University of Lübeck
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Retinal nerve fiber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetry
Explore Article SpringerLink Home (May 12 2010)
Abstract Optical coherence tomography (OCT) and scanning laser polarimetry (GDx ECC) are non-invasive methods used to assess retinal nerve fiber layer (RNFL) thickness, which may be a reliable tool used to monitor axonal loss in multiple sclerosis (MS). The objectives of this study are (1) to compare OCT with the GDx ECC; (2) to assess and compare the RNFL thickness in subgroups of MS. Ophthalmologic examination and RNFL assessment by OCT and GDx were performed in 65 MS patients (26 relapsing-remitting (RRMS), ten secondary-progressive (SPMS), 29 primary-progressive (PPMS)). Twenty-eight patients (43%) had a history of optic neuritis (ON). Adjustments were ...
Comment on Article Mentions: Thoraxcenter at Erasmus University Medical Center
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Patterns of retinal nerve fiber layer loss in multiple sclerosis patients with or without optic neuritis and glaucoma patients
Explore Article ScienceDirect (May 11 2010)
OBJECTIVE: Optical coherence tomography (OCT) has gained increasing attention in multiple sclerosis (MS) research and has been suggested as outcome measure for neuroprotective therapies. However, to date it is not clear whether patterns of retinal nerve fiber layer thickness (RNFLT) loss are different in MS compared to other diseases such as glaucoma and data on RNFLT loss in MS patients with or without optic neuritis (ON/NON) have remained inconsistent or even contradictory. METHODS: In this large cross-sectional study we analyzed the patterns of axonal loss of retinal ganglion cells in MS eyes (n=262) with and without history of ON (MS/ON: ...
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Preliminary investigation on use of high-resolution optical coherence tomography to monitor injury and repair in the rat sciatic nerve
Explore Article www3.interscience.wiley.com (May 1 2010)
Background and Objective Optical coherence tomography (OCT) has been used in limited settings to study peripheral nerve injury. The purpose of the study is to determine whether high-resolution OCT can be used to monitor nerve injury and regeneration in the rat sciatic nerve following crush injury, ligation, and transection with microsurgical repair. Study Design/Materials and Methods Forty-five rats were segregated into three groups. The right sciatic nerve was suture ligated (n = 15), cut then microsurgically repaired (n = 15), or crushed (n = 15). The left sciatic nerve served as the control; only surgical exposure and skin closure were ...
Comment on Article Mentions: Zhongping Chen UC Irvine Brian J. Wong
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Optic coherence tomography as a potential readout in clinical trials
Explore Article tan.sagepub.com (Apr 29 2010)
Optical coherence tomography (OCT) is a noninvasive tool used for measuring tissue at micrometer resolution. It has been extensively applied to ocular pathologies and is now being studied as a biomarker in various neurologic conditions. The retina represents a unique environment for study, with unmyelinated axons that directly synapse into the central nervous system. When trying to quantify axonal degradation in neurologic disease, the currently used imaging modalities are limited in sensitivity and specificity. Early data suggest that several neurologic conditions have pathologic changes in the retinal nerve fiber layer of the eye, creating a potential surrogate marker for neurodegeneration. ...
Comment on Article Mentions: UT Southwestern Medical Center Elliot M. Frohman
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Evaluating loss of visual function in multiple sclerosis as measured by low-contrast letter acuity
Explore Article Neurology (Apr 29 2010)
Background: Disturbances in visual function are common in patients with multiple sclerosis (MS) and are often accompanied by substantial impairments in daily functioning and quality of life. Lesions associated with these impairments frequently involve the afferent visual pathway. Expert Clinical Opinion: Because these impairments are often not readily apparent on commonly used high-contrast acuity tests, low-contrast charts (e.g., low-contrast Sloan letter charts) have gained validity in the assessment of visual dysfunction in patients with MS. Decrements in low-contrast letter acuity are associated with MS and correlate with increasing disability, MRI abnormalities, and reduced retinal nerve fiber layer (RNFL) thickness as ...
Comment on Article Mentions: Laura J. Balcer UT Southwestern Medical Center Elliot M. Frohman
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3D Eye Imaging Enters Neurology Offices
Explore Article businesswire.com (Apr 8 2010)
HEIDELBERG, Germany--(BUSINESS WIRE)--Heidelberg Engineering is introducing SPECTRALIS®, an office-based imaging device for tracking and measuring axonal change, at the 2010 meeting of the American Academy of Neurology in Toronto. The SPECTRALIS Tracking Laser Tomographer uses its on-board Nsite Axonal Analytics™ to track and measure axonal changes within the retinal nerve fiber layer (RNFL) by capturing high resolution cross-sectional images of the eye. “Even though SPECTRALIS offers 100 times higher resolution than an MRI, we don't expect our instrument to replace the role of MRI neurologists” .Numerous peer-reviewed clinical studies have been published in the last several years investigating the relationship ...
Comment on Article Mentions: Heidelberg Spectralis Heidelberg Engineering
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Time domain and spectral domain optical coherence tomography in multiple sclerosis: A comparative cross-sectional study
Explore Article Multiple Sclerosis (Mar 31 2010)
Conventional time domain optical coherence tomography has been established for the in vivo assessment of retinal axonal loss in multiple sclerosis. The innovative spectral domain imaging is superior to the conventional technique with respect to data acquisition speed, resolution and reproducibility. However, until now comparability of the two techniques has not been investigated in multiple sclerosis. In this study involving 55 multiple sclerosis patients, data obtained using both techniques (Stratus time domain optical coherence tomography and Cirrus spectral domain optical coherence tomography, Carl Zeiss Meditec) showed an excellent correlation (Pearson’s r = 0.926, p < 0.001). However, owing to considerable ...Comment on Article Mentions: Zeiss Stratus OCT Zeiss Cirrus HD-OCT Carl Zeiss Meditec
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Five Advances in Research and Drug Development for MS
Explore Article HealthCentral.com (Mar 29 2010)
Optical Coherence Tomography (OCT) - for many people the first signs of MS involve blurred version as caused by optic neuritis. It appears as if the very sensitive nerves in the back of the eye tend to be a vulnerable area for the onset of MS-related damage. OCT provides a sensitive, quantitative and easy way to measure the health of nerve fibers in the back of the eye. OCT holds the potential to assess the existence of nerve-related damage possibly before any other symptoms of MS have developed. As such, the possibility exists to allow earlier medical or treatment intervention ...
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Eric Swanson » Jim Fujimoto video: Biophotonics and optical coherence tomography
Great video Jim!
dariemihaela » Gary S. Mintz
Dear Prof. Dr. Gary S. Mintz, You are an extraordinary expert in imaging, an intelligence ...
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