1. Articles in category: Neurology

    1-24 of 446 1 2 3 4 ... 17 18 19 »
    1. The APOSTEL recommendations for reporting quantitative optical coherence tomography studies

      The APOSTEL recommendations for reporting quantitative optical coherence tomography studies

      Objective: To develop consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results. Methods: A panel of experienced OCT researchers (including 11 neurologists, 2 ophthalmologists, and 2 neuroscientists) discussed requirements for performing and reporting quantitative analyses of retinal morphology and developed a list of initial recommendations based on experience and previous studies. The list of recommendations was subsequently revised during several meetings of the coordinating group. Results: We provide a 9-point checklist encompassing aspects deemed relevant when reporting quantitative OCT studies. The areas covered are study protocol, acquisition device, acquisition settings, scanning protocol, funduscopic imaging, postacquisition data selection ...

      Read Full Article
    2. Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

      Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

      Although retinal vasculitis is common in multiple sclerosis (MS), it is not known if MS is associated with quantitative abnormalities in retinal blood vessels (BVs). Optical coherence tomography (OCT) is suitable for examining the integrity of the anterior visual pathways in MS. In this paper we have compared the size and number of retinal blood vessels in patients with MS, with and without a history of optic neuritis (ON), and control subjects from the cross-sectional retinal images from OCT. Blood vessel diameter (BVD), blood vessel number (BVN), and retinal nerve fiber layer thickness (RNFL T ) were extracted from OCT images ...

      Read Full Article
    3. Adding Papillomacular Bundle Measurements to Standard Optical Coherence Tomography Does Not Increase Sensitivity to Detect Prior Optic Neuritis in Patients with Multiple Sclerosis

      Adding Papillomacular Bundle Measurements to Standard Optical Coherence Tomography Does Not Increase Sensitivity to Detect Prior Optic Neuritis in Patients with Multiple Sclerosis

      Purpose To improve the detection of retinal nerve fiber layer (RNFL) thinning in multiple sclerosis (MS), a special peripapillary ring scanning algorithm (N-site RNFL, N-RNFL) was developed for spectral domain optical coherence tomography (SD-OCT). In contrast to the standard protocol (ST-RNFL) scanning starts nasally, not temporally, and provides an additional sector of analysis, the papillomacular bundle (PMB). We aimed to ascertain whether the temporal RNFL differs between the two techniques, whether N-RNFL is more sensitive than ST-RNFL to detect previous optic neuritis (ON), and whether analyzing the PMB adds additional sensitivity. Furthermore, we investigated whether RNFL is associated with disease ...

      Read Full Article
    4. Polarization sensitive optical coherence microscopy for brain imaging

      Polarization sensitive optical coherence microscopy for brain imaging

      Optical coherence tomography (OCT) and optical coherence microscopy (OCM) have demonstrated the ability to investigate cyto- and myelo-architecture in the brain. Polarization-sensitive OCT provides sensitivity to additional contrast mechanisms, specifically the birefringence of myelination and, therefore, is advantageous for investigating white matter fiber tracts. In this Letter, we developed a polarization-sensitive optical coherence microscope (PS-OCM) with a 3.5 μm axial and 1.3 μm transverse resolution to investigate fiber organization and orientation at a finer scale than previously demonstrated with PS-OCT. In a reconstructed mouse brain section, we showed that at the focal depths of 20–70 μm, the ...

      Read Full Article
    5. Optical Coherence Tomography and neurodegeneration: are eyes the windows to the brain?

      Optical Coherence Tomography and neurodegeneration: are eyes the windows to the brain?

      Central nervous system (CNS) pathologies have ocular manifestations due to direct and/or retrograde degeneration of the visual pathways, most often related to a direct injury to the optic nerve, retinal ganglion cells and/or its surrounding cells. These ocular manifestations can be recognized and monitored by a non-invasive technique called Optical Coherence Tomography (OCT). OCT helps in the measurement of retinal nerve fiber layer (RNFL) thickness and macular thickness which consists of retinal ganglion cells. OCT provides a near-histological level of image resolution up to 5µm by using principles of interferometry that can detect CNS inflammatory, as well ...

      Read Full Article
    6. Timing of retinal neuronal and axonal loss in MS: a longitudinal OCT study

      Timing of retinal neuronal and axonal loss in MS: a longitudinal OCT study

      The objective of the study was to investigate the timing of central nervous system tissue atrophy in MS by evaluating longitudinal retinal volume changes in a broadly representative cohort with disease duration across the entire arc of disease. In this longitudinal study, 135 patients with MS and 16 healthy reference subjects underwent spectral-domain optical coherence tomography (OCT) at baseline and 2 years later. Following OCT quality control, automated segmentation of the peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell–inner plexiform layer (mGCIPL) and macular inner nuclear layer (mINL) was performed. Generalized estimation equations were used to analyze longitudinal ...

      Read Full Article
    7. Optical Coherence Tomography in Multiple Sclerosis

      Optical Coherence Tomography in Multiple Sclerosis

      Retinal optical coherence tomography (OCT) has recently become a vital tool for clinicians and researchers in ophthalmology and, increasingly, in neurology. Optical coherence tomography is quickly and easily performed, well-tolerated by patients, and allows high-resolution viewing of unmyelinated axons and other retinal structures in vivo. These factors have led OCT to find favor as a method of quantifying neuroaxonal loss in multiple sclerosis (MS), and the increasing acceptance of the anterior visual pathway as a model to investigate MS in humans. In this short review, the authors discuss OCT findings in MS research, and the relationships of these structural findings ...

      Read Full Article
    8. Duration of the depressive episode is correlated with ganglion cell inner plexifrom layer and nasal retinal fiber layer thicknesses: Optical coherence tomography findings in major depression

      Duration of the depressive episode is correlated with ganglion cell inner plexifrom layer and nasal retinal fiber layer thicknesses: Optical coherence tomography findings in major depression

      • OCT has been used in various neurodegenerative diseases to visualize the process of neurodegeneration. • We assessed 58 patients with major depression and 57 healthy controls in terms of optical coherence tomography. • Depressed patients were not diferent from the healthy controls with regard to OCT parameters. • Ganglion cell-inner plexiform layer and nasal retinal fiber layer were correlated with the duration of the latest depressive episode.

      Read Full Article
    9. Optical Coherence Tomography Angiography in a Patient with Optic Atrophy After Non-arteritic Anterior Ischaemic Optic Neuropathy

      Optical Coherence Tomography Angiography in a Patient with Optic Atrophy After Non-arteritic Anterior Ischaemic Optic Neuropathy

      A 75-year-old female noticed a lower visual field (VF) defect in the right eye. A diagnosis of non-arteritic anterior ischaemic optic neuropathy (NAION) was made. The lower VF defect in the right eye did not change after onset. Optical coherence tomography (OCT) angiograms on the disc and the macula showed decreased retinal perfusion in the upper retina of the right eye. Retinal nerve fibre layer loss and ganglion cell complex loss in the upper retina were also seen in the right eye. OCT angiography could non-invasively detect the decrease of the retinal perfusion due to NAION.

      Read Full Article
    10. Optical coherence tomography findings in a patient with type 1 sialidosis

      Optical coherence tomography findings in a patient with type 1 sialidosis

      Type 1 sialidosis is a metabolic storage disorder characterised by the accumulation of sialylated oligosaccharides. The condition is also known as macular cherry-red spot and myoclonus syndrome due to the characteristic macular appearance in affected individuals. This case outlines the presentation of a patient with type 1 sialidosis, including ophthalmological assessment with retinal photography and spectral domain optical coherence tomography (OCT). OCT scans showed thickening of the perimacular and peripapillary retinal nerve fibre layer, thought to be due to the abnormal accumulation of metabolic products. The cherry-red spot appearance is due to the normal appearing macula being seen in contrast ...

      Read Full Article
    11. OCT in Central Nervous System Disease: The Eye as a Window to the Brain (Textbook)

      OCT in Central Nervous System Disease: The Eye as a Window to the Brain (Textbook)

      This book reviews recent important advances in the use of optical coherence tomography (OCT) in order to analyze neurodegeneration within the retina through the quantification of axonal loss. Detailed information is provided on the role of OCT as a promising tool for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. The disorders considered include multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment ...

      Read Full Article
    12. Optical Coherence Tomography in Neurologic Disease (Textbook)

      Optical Coherence Tomography in Neurologic Disease (Textbook)

      Shortly after the invention of the first two-dimensional optical coherence tomography (OCT) scans by James Fujimoto and colleagues at the Massachusetts Institute of Technology in 1991, ophthalmologists recognized the extraordinary potential for OCT to facilitate quantitative assessment of the neuroretina. OCT rapidly became a commonplace tool in ophthalmologic practice to identify both inflammatory and degenerative conditions affecting the optic nerve and retina. The utility of OCT to detect and quantify sequelae of optic neuropathies, including glaucoma and those associated with primary neurological diseases , was soon brought to the forefront. Rapid advances in the technology have followed and have included faster ...

      Read Full Article
    13. Optical coherence tomography in multiple sclerosis

      Optical coherence tomography in multiple sclerosis

      In patients with multiple sclerosis, thinner peripapillary retinal nerve fibre layers (pRNFL) and retinal ganglion cell layers in eyes without previous optic neuritis, as measured with optical coherence tomography (OCT), have been associated with global brain atrophy and disability. Although most of the data so far have been obtained in cross-sectional studies, the idea to use OCT parameters as surrogate markers of neuroaxonal degeneration and multiple sclerosis disability has been put forth by Elena Martinez-Lapiscina and colleagues 1 in The Lancet Neurology .

      Read Full Article
    14. Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

      Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

      Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study, we collected data about patients (age ≥16 years old) with clinically isolated syndrome, relapsing-remitting multiple sclerosis, and progressive multiple sclerosis. Patients were recruited from centres in Spain, Italy, France, Germany ...

      Read Full Article
    15. Application of optical coherence tomography based microangiography for cerebral imaging

      Application of optical coherence tomography based microangiography for cerebral imaging

      Requirements of in vivo rodent brain imaging are hard to satisfy using traditional technologies such as magnetic resonance imaging and two-photon microscopy. Optical coherence tomography (OCT) is an emerging tool that can easily reach at high speeds and provide high resolution volumetric images with a relatively large field of view for rodent brain imaging. Here, we provide the overview of recent developments of functional OCT based imaging techniques for neuroscience applications on rodents. Moreover, a summary of OCT-based microangiography (OMAG) studies for stroke and traumatic brain injury cases on rodents are provided.

      Read Full Article
    16. Ex vivo brain tumor analysis using spectroscopic optical coherence tomography

      Ex vivo brain tumor analysis using spectroscopic optical coherence tomography

      A big challenge during neurosurgeries is to distinguish between healthy tissue and cancerous tissue, but currently a suitable non-invasive real time imaging modality is not available. Optical Coherence Tomography (OCT) is a potential technique for such a modality. OCT has a penetration depth of 1-2 mm and a resolution of 1-15 μm which is sufficient to illustrate structural differences between healthy tissue and brain tumor. Therefore, we investigated gray and white matter of healthy central nervous system and meningioma samples with a Spectral Domain OCT System (Thorlabs Callisto). Additional OCT images were generated after paraffin embedding and after the samples ...

      Read Full Article
    17. Optical technologies for intraoperative neurosurgical guidance

      Optical technologies for intraoperative neurosurgical guidance

      Biomedical optics is a broadly interdisciplinary field at the interface of optical engineering, biophysics, computer science, medicine, biology, and chemistry, helping us understand light–tissue interactions to create applications with diagnostic and therapeutic value in medicine. Implementation of biomedical optics tools and principles has had a notable scientific and clinical resurgence in recent years in the neurosurgical community. This is in great part due to work in fluorescence-guided surgery of brain tumors leading to reports of significant improvement in maximizing the rates of gross-total resection. Multiple additional optical technologies have been implemented clinically, including diffuse reflectance spectroscopy and imaging, optical ...

      Read Full Article
    18. Optical coherence tomography of the optic nerve head detects acute changes in intracranial pressure

      Optical coherence tomography of the optic nerve head detects acute changes in intracranial pressure

      We aimed to determine if there are measurable objective changes in the optic nerve head (ONH) immediately after cerebrospinal fluid (CSF) drainage in a prospective case-series of five patients undergoing a clinically indicated lumbar puncture (LP) for diagnosis of idiopathic intracranial hypertension. A Cirrus high-definition optical coherence tomography machine (Carl Zeiss Meditec, Dublin, CA, USA) was used to acquire images in the lateral decubitus position. Optic disc cube and high-definition line raster scans centered on the ONH were obtained immediately before and after draining CSF, while the patient maintained the lateral decubitus position. Measured parameters included retinal nerve fiber layer ...

      Read Full Article
    19. A Case Series of Dural Venous Sinus Stenting in Idiopathic Intracranial Hypertension: Association of Outcomes with Optical Coherence Tomography

      A Case Series of Dural Venous Sinus Stenting in Idiopathic Intracranial Hypertension: Association of Outcomes with Optical Coherence Tomography

      Purpose/Aim : Pseudotumor cerebri, or idiopathic intracranial hypertension (IIH), is characterized by increased intracranial pressure of unknown etiology. A subset of patients has shown benefit from endovascular dural venous sinus stenting (DVSS). We sought to identify a population of IIH patients who underwent DVSS to assess outcomes. Materials and Methods : A retrospective study was performed to identify IIH patients with dural sinus stenosis treated with DVSS. Outcome measures included dural sinus pressure gradients, peripapillary retinal nerve fiber layer thickness using optical coherence tomography, and improvement in symptoms. Results : Seventeen patients underwent DVSS. Average pre- and post-intervention pressure gradients were 23 ...

      Read Full Article
    20. Ophthalmological assessment of OCT and electrophysiological changes in migraine patients

      Ophthalmological assessment of OCT and electrophysiological changes in migraine patients

      Background: A cross-sectional study to investigate the morphological and functional changes of the visual pathway, taking place in patients with migraine. Methods: Fifteen patients (14 female, 1 male) diagnosed with migraine with aura (MA group) and 23 patients (21 female, 2 male) diagnosed with migraine without aura (MO group) were compared to 20 healthy volunteers (18 Female, 2 male). All the participants underwent optical coherence tomography (OCT) scan, electroretinogram (ERG), visual evoked potentials (VEP), and multifocal electroretinogram (mf-ERG) recording. Results: Assessing ERG recordings, no significant differences in mean N1-P1 amplitudes were measured among the groups. The mean VEP N80-P100 amplitudes ...

      Read Full Article
    21. Review of optical coherence tomography based angiography in neuroscience

      Review of optical coherence tomography based angiography in neuroscience

      The brain is a complex ecosystem, consisting of multiple layers and tissue compartments. To facilitate the understanding of its function and its response to neurological insults, a fast in vivo imaging tool with a micron-level resolution, which can provide a field of view at a few millimeters, is desirable. Optical coherence tomography (OCT) is a noninvasive method for imaging three-dimensional biological tissues with high resolution ( ∼ 10    μ m ∼10  μm ) and without a need for contrast agents. Recent development of OCT-based angiography has started to shed some new light on cerebral hemodynamics in neuroscience. We give an overview of the recent ...

      Read Full Article
    22. Macular Ganglion Cell Layer and Peripapillary Retinal Nerve Fibre Layer Thickness in Patients with Unilateral Posterior Cerebral Artery Ischaemic Lesion: An Optical Coherence Tomography Study

      Macular Ganglion Cell Layer and Peripapillary Retinal Nerve Fibre Layer Thickness in Patients with Unilateral Posterior Cerebral Artery Ischaemic Lesion: An Optical Coherence Tomography Study

      The purpose of this study is to evaluate the macular ganglion cell layer (GCL) and peripapillary retinal nerve fibre layer (RNFL) thickness in patients with unilateral posterior cerebral artery (PCA) ischaemic lesions using spectral-domain optical coherence tomography (SD-OCT). A prospective, case-control study of patients with unilateral PCA lesion was conducted in the neuro-ophthalmology clinic of Centro Hospitalar Lisboa Central. Macular and peripapillary SD-OCT scans were performed in both eyes of each patient. Twelve patients with PCA lesions (stroke group) and 12 healthy normal controls were included in this study. Peripapillary RNFL comparison between both eyes of the same subject in ...

      Read Full Article
    23. Optical Coherence Tomography for the Detection of Remote Optic Neuritis in Multiple Sclerosis

      Optical Coherence Tomography for the Detection of Remote Optic Neuritis in Multiple Sclerosis

      BACKGROUND AND PURPOSE Evidence of remote optic neuritis is often used to support a diagnosis of multiple sclerosis (MS). Optical coherence tomography (OCT) can provide qualitative and quantitative data on the retina, where the effects of optic neuritis can be seen. Our aim was to determine whether there is a quantitative difference in retinal structures in eyes with optic neuritis compared with those without, and which measures were best able to discriminate eyes with a history of optic neuritis from nonoptic neuritis eyes in MS patients. METHODS We performed a prospective cohort study of 30 MS-optic neuritis patients, 22 MS-nonoptic ...

      Read Full Article
      Mentions: Peter K. Kaiser
    1-24 of 446 1 2 3 4 ... 17 18 19 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Popular Articles

  3. Organizations in the News

    1. (2 articles) UCSF
    2. (2 articles) Heinrich-Heine University Düsseldorf
    3. (1 articles) Academic Medical Center at the University of Amsterdam
    4. (1 articles) Johns Hopkins University
    5. (1 articles) Harvard University
    6. (1 articles) University of Illinois at Urbana-Champaign
    7. (1 articles) VU University Amsterdam
    8. (1 articles) State University of New York at Buffalo
    9. (1 articles) University of Heidelberg
    10. (1 articles) University of Alabama
    11. (1 articles) University of Freiburg
    12. (1 articles) University College London
  4. People in the News

    1. (2 articles) Axel Petzold
    2. (2 articles) Ari J. Green
    3. (1 articles) Peter A. Calabresi
    4. (1 articles) Joel S. Schuman
    5. (1 articles) Friedemann Paul
    6. (1 articles) Hui Wang
    7. (1 articles) Timm Oberwahrenbrock
    8. (1 articles) Stephen A. Boppart
    9. (1 articles) David A. Boas
    10. (1 articles) Taner Akkin
    11. (1 articles) Ryan L. Shelton
    12. (1 articles) Laura J. Balcer
  5. OCT Companies in the News

    1. (1 articles) Heidelberg Engineering
    2. (1 articles) Nidek