1. Articles in category: Textbooks

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    1. Optical Coherence Tomography for Prostate Cancer and Beyond (Book Chapter)

      Optical Coherence Tomography for Prostate Cancer and Beyond (Book Chapter)

      Since it was first used to evaluate human genitourinary tissue in 1997, OCT has emerged as a promising modality to provide real-time, high-resolution imaging of urologic organs. In the bladder, it has demonstrated a high sensitivity in identifying regions of the bladder suspicious for CIS and between invasive and noninvasive malignancy; it has been studied as an “optical biopsy” both during the initial cystoscopic diagnosis and intraoperatively in bladder-preserving surgery. Several small, ex vivo studies have shown promising results in the ability of OCT to demonstrate histopathologic alterations to renal morphology such as in renal ischemia and malignancy. It may ...

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    2. Optical Coherence Tomography in Bladder Cancer (Book Chapter)

      Optical Coherence Tomography in Bladder Cancer (Book Chapter)

      The current diagnostic standard for grading and staging of non-muscle-invasive bladder cancer (NMIBC) is based on the histopathology obtained during transurethral resection of the bladder tumour (TURBT) or biopsies. Although considered reference standard, this technique has some limitations: First, no real-time intraoperative histological information is obtained on stage and grade. Real-time intraoperative histological information could be helpful when NMIBC is treated by electric coagulation or laser ablation. The urologist has to rely on his/her judgement of stage and grade since no tissue is harvested for histological confirmation. In addition, in many centres, patients with a history of low-grade, non-invasive ...

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    3. Innovations in Microscopic Imaging of Atherosclerosis and Valvular Disease (Book Chapter)

      Innovations in Microscopic Imaging of Atherosclerosis and Valvular Disease (Book Chapter)

      Calcific aortic valve disease (CAVD) is still an unsolved medical problem, because the pathogenesis of CAVD is poorly understood and early calcification is hard to identify. The lack of high-resolution imaging tools to study early stage disease further hampers the search for therapeutic targets. Micro-optical coherence tomography (μOCT), which is a new form of OCT, is the highest-resolution cross-sectional OCT technology available today with 1 μm resolution. We used μOCT to visualize detailed cellular and subcellular structure associated with early calcific changes in diseased human and murine aortic valves. The results suggest that μOCT imaging has the potential to provide ...

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    4. Optical Coherence Tomography: OCT (Book Chapter)

      Optical Coherence Tomography: OCT (Book Chapter)

      Optical coherence tomography (OCT) allows to measure geometric features inside translucent objects such as organic materials or organic tissues. The principle is based on interferometry. Time-domain and Fourier-domain methods are applied to make visible differences in the refractive index profile of the measuring object. We present the set-up of OCT sensors and show examples of applications such as 3D-imaging of an eye, B-scans of blood vessels or thickness measurements of multi-layer polymer films.

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    5. Optical Coherence Tomography and Cryosurgery (Book Chapter)

      Optical Coherence Tomography and Cryosurgery (Book Chapter)

      Optical coherence tomography (OCT) provides real-time, cross-sectional skin images to a depth of up to 2 mm. OCT is a convenient and fast imaging technology that can be used bedside. In dermatology, the pretherapeutic delineation of both actinic keratoses (AK) and keratinocyte carcinomas has been a natural focus for applied OCT research, and more recently OCT research has turned on non-invasive monitoring of treatments. Previous studies have found good agreement between OCT images and histopathological images. Cryotherapy is a fast and easy treatment modality frequently used for the treatment of AK lesions in everyday dermatology practise. Cryosurgery with liquid nitrogen ...

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    6. Clinical Guide to Angio-OCT (Non Invasive, Dyeless OCT Angiography) (Textbook)

      Clinical Guide to Angio-OCT (Non Invasive, Dyeless OCT Angiography)  (Textbook)

      The book discusses the clinical possibilities of Angio-OCT. Most imaging in the book (77 figures in Chapters 5, 7.1 and 10) has been performed with XR-Avanti Optovue SD-OCT device using SSADA algorithm. A few figures in chapters 3, 7.2 and 8 have been performed with a swept source OCT prototype using SSADA algorithm. Another technique is described in chapter 11, using ultrahigh speed, SS-OCT and its applications to optical coherence tomography-angiography (OCTA). Key Features Angio-OCT (Dyeless OCT Angiography) is a new TECHNOLOGY that gives already useful results, that can be applied to day-to-day clinical ophthalmology. Several different OCT ...

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    7. Principles and Applications of Fourier Optics (Textbook)

      Principles and Applications of Fourier Optics (Textbook)

      `All of optics is Fourier optics!' While this statement may not be literally true, when there is one basic mathematical tool to explain light propagation and image formation, with both coherent and incoherent light, as well as thousands of practical everyday applications of the fundamentals, Fourier optics is worth studying. This book contains summaries of the principles of Fourier optics that have been developed over the past hundred years and of many applications over the past fifty years, especially since the invention of the laser. This book is intended as a series of guideposts to improve our world through the ...

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    8. Ophthalmological Imaging and Applications (Textbook)

      Ophthalmological Imaging and Applications (Textbook)

      Edited by and featuring contributions from world-class researchers, Ophthalmological Imaging and Applications offers a unified work of the latest human eye imaging and modeling techniques that have been proposed and applied to the diagnosis of ophthalmologic problems, including inflammation, cataracts, diabetic retinopathy, and glaucoma. With a focus on theory, basic principles, and results derived from research, the book: Explores various morphological, textural, higher-order spectral, and wavelet transformation techniques used to extract salient features from images of the human eye Examines 2D and 3D finite element and boundary element models of the human eye developed to simulate thermal steady-state conditions Addresses ...

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    9. Optical Coherence Tomography (Textbook)

      Optical Coherence Tomography (Textbook)

      Because of its many advantages optical coherence tomography (OCT) has revolutionized the way in which retinal diseases are screened and managed and how treatments are monitored. In this volume the latest developments and findings are presented by experts in their respective fields. After a short introduction covering the available equipment and the basic techniques, the imaging features of various pathological findings in retinal diseases are presented. The topics cover the outer layers including new modalities for choroid imaging, out-layer diseases such as the various types of macular degeneration, retinal diseases such as diabetic retinopathy and vascular occlusion, and retina and ...

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    10. Handbook of Retinal OCT: Optical Coherence Tomography, 1st Edition (Textbook)

      Handbook of Retinal OCT: Optical Coherence Tomography, 1st Edition (Textbook)

      With Handbook of Retinal OCT , you can master the latest imaging methods used to evaluate retinal disease, uveitis, and optic nerve disorders. Ideal at any stage of your career, this easy-to-use, clinically oriented handbook provides a quick, templated, and portable guide for the interpretation of Optical Coherence Tomography scans. Key Features: Locate answers quickly with templated chapters-each focused on one specific diagnosis or group of diagnoses with a particular OCT appearance; Adopt the latest techniques for evaluating age-related macular degeneration, diabetic retinopathy, retinal vein occlusion, and much more; See how the full spectrum of diseases presents through approximately 370 illustrations ...

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    11. Optical Coherence Tomography as a Biomarker in Clinical Trials for Ophthalmology and Neurology (Book Chapter)

      Optical Coherence Tomography as a Biomarker in Clinical Trials for Ophthalmology and Neurology (Book Chapter)

      In the past, clinical trials in neuro-ophthalmology have focused upon functional endpoints including Snellen visual acuity and visual field testing, both of which may have significant test/retest variability because of their dependence upon subject alertness and cognitive function. The introduction of optical coherence tomography (OCT) into the practice of clinical ophthalmology has now extended into clinical trials in both ophthalmology and neurology. Recent advances in the resolution and reproducibility of spectral-domain OCT have now produced algorithms that measure the structural integrity of the optic nerve and retina. OCT is in vivo histopathology and the qualitative and quantitative metrics of ...

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    12. Ophthalmology, 4th Edition (Textbook)

      Ophthalmology, 4th Edition (Textbook)

      Get the quick answers you need on every aspect of clinical ophthalmology and apply them in your day-to-day practice . The latest edition of Ophthalmology by Drs. Yanoff and Duker presents practical, expert, concise guidance on nearly every ophthalmic condition and procedure, equipping you to efficiently overcome whatever clinical challenges you may face.

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    13. Vascular Imaging of the Central Nervous System: Physical Principles, Clinical Applications and Emerging Techniques (Textbook)

      Vascular Imaging of the Central Nervous System: Physical Principles, Clinical Applications and Emerging Techniques (Textbook)

      The first book-length reference to thoroughly describe diagnostic and therapeutic advances in the development of vascular radiology over the last decade The last ten years has seen vascular imaging of the central nervous system (CNS) evolve from fairly crude, invasive procedures to more advanced imaging methods that are safer, faster, and more precise—with computed tomographic (CT) and magnetic resonance (MR) imaging methods playing a special role in these advances. Vascular Imaging of the Central Nervous System is the first full-length reference text that shows radiologists—especially neuroradiologists—how to optimize the use of the many techniques available in order ...

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    14. Non Invasive Diagnostic Techniques in Clinical Dermatology (Textbook)

      Non Invasive Diagnostic Techniques in Clinical Dermatology (Textbook)

      Optical coherence tomography (OCT) is a noninvasive imaging method. Using infrared broadband light sources, images of superficial skin layers can be obtained in vivo and real time. In dermatology, OCT can be used for investigation of skin tumors and inflammatory skin diseases, for quantification of skin changes, and for evaluation of treatment effects

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    15. Diagnostic Endoscopy (Textbook)

      Diagnostic Endoscopy (Textbook)

      Combining a professional development course on diagnostic endoscopy from SPIE (the international society advancing light-based research) and the authors’ graduate course on biomedical optics, this work is written for researchers in medical optics and biomedical engineering as well as graduate medical optics students. It uses extensive examples/case studies to familiarize readers with the basics of endoscopic optics, the pros and cons of white light endoscopy and fluorescence endoscopy for diagnostic applications, and various microscopic endoscopy imaging modalities. It covers basic optics, details of design and biomedical uses, as well as microscopic endoscopy, and endoscopic spectroscopy.

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    16. Diagnostic Techniques: Optical Coherence Tomography (Book Chapter)

      Diagnostic Techniques: Optical Coherence Tomography (Book Chapter)

      Optical coherence tomography (OCT) is a powerful imaging technique that provides cross-sectional imaging of the internal microstructures of biological tissues. Among several implementations of OCT, spectral-domain OCT (SD-OCT) provides high-resolution, high-sensitivity, and high-speed imaging. Such implementations enable visualization of the microstructures of the human eye by noninvasive and noncontact measurement. High sensitivity of OCT detection enables imaging of structures with very low optical scattering, such as the retina. The high axial and lateral resolution enables the precise morphological investigation of various pathological conditions. Recently, hardware and software upgrades have improved the ability to better evaluate intraocular tumors.

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    17. Multi-Modality Atherosclerosis Imaging and Diagnosis (Textbook)

      Multi-Modality Atherosclerosis Imaging and Diagnosis (Textbook)

      Stroke is one of the leading causes of death in the world, resulting mostly from the sudden ruptures of atherosclerosis carotid plaques. However, until now, the exact plaque development/rupture mechanism has not been fully understood, and also the plaque rupture risk stratification. From biomechanical viewpoint, plaque initiation and development could be attributed to the disturbed flow in those arteries, and the sudden rupture of plaque can be resulted from plaque structure stability failure due to the mechanical stress in/outside plaque structure. Understanding this phenomenonwhy and how plaque develops and ruptures requires a multidisciplinary approach such as radiology, biomedical ...

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    18. New Trends in Ophthalmology Medical and Surgical Management (Textbook)

      New Trends in Ophthalmology Medical and Surgical Management (Textbook)

      ew Trends in Ophthalmology presents ophthalmologists with the most recent technological developments in this rapidly advancing field. Each chapter explains current diagnosis and medical and surgical management of different ocular disorders and diseases, including cataract surgery, glaucoma treatment and lens implant surgery. Presented in an easy to follow format, this comprehensive manual is enhanced by nearly 400 clinical photographs, diagrams and tables.

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    19. Optical Techniques in Regenerative Medicine (Textbook)

      Optical Techniques in Regenerative Medicine (Textbook)

      In regenerative medicine, tissue engineers largely rely on destructive and time-consuming techniques that do not allow in situ and spatial monitoring of tissue growth. Furthermore, once the therapy is implanted in the patient, clinicians are often unable to monitor what is happening in the body. To tackle these barriers, optical techniques have been developed to image and characterize many tissue properties, fabricate tissue engineering scaffolds, and characterize the properties of the scaffolds. Optical Techniques in Regenerative Medicine illustrates how to use optical imaging techniques and instrumentation for the fabrication, assessment, and longitudinal monitoring of regenerative medicine therapies. The book covers ...

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    20. Optical Coherence Tomography in Barrett's Esophagus (Book Chapter)

      Optical Coherence Tomography in Barrett's Esophagus (Book Chapter)

      The incidence of Barrett's-related adenocarcinoma of the esophagus continues to increase at an alarming rate.  Studies to date show great promise for optical coherence tomography (OCT) in screening, surveillance, and guiding management of Barrett's esophagus.  With continued innovation in rapid, accurate scanning systems, such as volumetric laser endomicroscopy or optical frequency domain imaging, advanced OCT seems likely to have an important impact.  The next fes years are likely to see the initiation of large clinical studies that will define the extend and significance of this impact.

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    21. Imaging in Cellular and Tissue Engineering (Book)

      Imaging in Cellular and Tissue Engineering (Book)

      Details on specific imaging modalities for different cellular and tissue engineering applications are scattered throughout articles and chapters in the literature. Gathering this information into a single reference, Imaging in Cellular and Tissue Engineering presents both the fundamentals and state of the art in imaging methods, approaches, and applications in regenerative medicine. The book underscores the broadening scope of imaging applications in cellular and tissue engineering. It covers a wide range of optical and biological applications, including the repair or replacement of whole tissues (such as bone, cartilage, blood vessels, and bladder) and more novel artificially created support systems (such ...

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    22. Clinical and Research Applications of Optical Coherence Tomography Imaging in Coronary Artery Disease (Book Chapter)

      Clinical and Research Applications of Optical Coherence Tomography Imaging in Coronary Artery Disease (Book Chapter)

      Optical coherence tomography (OCT) is an optical analog of intravascular ultrasound (IVUS) that allows microscopic visualization of coronary plaque types and intracoronary tissue. The high-resolution images of OCT produce an intense interest in adopting this imaging technique for both clinical and research purposes. In clinical aspects, OCT imaging for undergoing percutaneous coronary intervention (PCI) is feasible and provides superior resolution of arterial pathology than IVUS. During PCI, OCT can assess pre-procedural coronary plaque morphology and acute effects of coronary intervention (dissection, tissue prolapse, thrombi, and incomplete stent apposition (ISA)). Moreover, OCT provides more useful information to consider PCI strategy, such ...

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    23. Optical Coherence Tomography Principles and Applications Second Edition (Book)

      Optical Coherence Tomography Principles and Applications Second Edition (Book)

      Optical coherence tomography is a medical high-resolution imaging technology which offers several distinct advantages over current medical imaging technologies. With a resolution 25x greater than current technologies, its ability to be engineered very small due to its fiber-based design these devices, and it is high speed with frame rates close to video rates, this technology is attracting a great many researchers. This second edition brings together information needed by the various, and sometimes disparate, groups using and studying this technology. It is completely updated throughout with the most recent research and applications. This is not a book on how to ...

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