1. Articles in category: Textbooks

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    1. Optical Coherence Tomography in Glaucoma (Textbook)

      Optical Coherence Tomography in Glaucoma (Textbook)

      Optical coherence tomography (OCT) is a noninvasive diagnostic imaging modality that enables ophthalmologists to visualize different layers of the optic nerve and retinal nerve fiber layer (RNFL) with astounding detail. Today, OCT is an instrumental tool for screening, diagnosing, and tracking the progression of glaucoma in patients. Optical Coherence Tomography in Glaucoma by renowned glaucoma specialist Jullia A. Rosdahl and esteemed contributors is a one-stop, unique resource that summarizes the clinical utility of this imaging technology, from basics to advanced analyses. The book features 14 chapters, starting with introductory chapters that discuss development of OCT and its applications for visualizing ...

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    2. Functionalized contrast agents for multimodality photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy molecular retinal imaging (Book Chapter)

      Functionalized contrast agents for multimodality photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy molecular retinal imaging (Book Chapter)

      Near-infrared (NIR) targeting contrast agents have been investigated as great photoabsorbers to improve photoacoustic microscopy (PAM), OCT, and fluorescence imaging contrast for visualization of various diseases. In ophthalmology, a limited number of NIR contrast agents have been approved for clinical use. Recently, gold nanoparticles with different size and shapes have been developed for molecular imaging. This chapter provides the principles of multimodality PAM, OCT, and fluorescence imaging as well as a brief overview of contrast agents for optical imaging. A detailed protocol for the fabrication of discrete colloidal gold nanoparticles (GNPs), synthesis of functionalized RGD-conjugated chain-like GNP (CGNP) clusters labeled ...

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    3. Optical Coherence Tomography for Melanoma Detection (Book Chapter)

      Optical Coherence Tomography for Melanoma Detection (Book Chapter)

      Tissue contrast in optical coherence tomography (OCT) images is generated by the intrinsic characteristics that are proportional to the density, size, and shape of tissue microstructures. Extraction of tissue optical properties from OCT images is therefore a generic method for obtaining quantitative information about tissue microstructure. The sensitivity and specificity of conventional OCT by assessing morphology only for melanoma detection is lower than anticipated. The aggregation of the predominant optical properties that contribute to OCT image formation diminishes the specificity of melanoma detection due to interrelationships of these properties. Importantly, the optical properties come at no additional cost as they ...

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    4. The role of optical coherence tomography in the diagnosis of afferent visual pathway problems: A neuroophthalmic perspective (Book Chapter)

      The role of optical coherence tomography in the diagnosis of afferent visual pathway problems: A neuroophthalmic perspective (Book Chapter)

      Optical coherence tomography (OCT) is a noninvasive ocular imaging technique that has become a standard tool in neuroophthalmic practice. Specifically, OCT captures retinal manifestations of neuroaxonal injury caused by lesions along anterior and posterior regions of the afferent visual pathway, in patients presenting with vision loss. More recently, the advent of OCT angiography (OCTA) has enabled evaluation of the choroidal and retinal microvasculature, thus informing our understanding regarding vascular mechanisms associated with optic nerve and retinal injuries. Much of our longitudinal experience with OCT in the field of neuroophthalmology has been acquired from the study of optic neuritis (ON) caused ...

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    5. Optical Coherence Tomography in Uveitis (Book Chapter)

      Optical Coherence Tomography in Uveitis (Book Chapter)

      Uveitis is the comprehensive reference you need for a balanced approach to basic science and clinical application. Robert B. Nussenblatt and Scott M. Whitcup provide a cohesive and integrated discussion of the topic, covering everything from the role of surgery to AIDS to anterior uveitis and more. This new edition even includes full color throughout, 400 photographs and illustrations, and searchable access to the text online at expertconsult.com. Comprehensive yet readable, this resource packs everything you need in patient evaluation and management to achieve optimal results.

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    6. Emerging Biomedical Imaging Optical Coherence Tomography (Book Chapter)

      Emerging Biomedical Imaging Optical Coherence Tomography (Book Chapter)

      This transformative textbook, first of its kind to incorporate engineering principles into medical education and practice, will be a useful tool for physicians, medical students, biomedical engineers, biomedical engineering students, and healthcare executives. The central approach of the proposed textbook is to provide principles of engineering as applied to medicine and guide the medical students and physicians in achieving the goal of solving medical problems by engineering principles and methodologies. For the medical students and physicians, this proposed textbook will train them to “think like an engineer and act as a physician”. The textbook contains a variety of teaching techniques ...

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    7. Integrated Intraoperative Optical Coherence Tomography in Pediatric Glaucoma Surgery (Textbook)

      Integrated Intraoperative Optical Coherence Tomography in Pediatric Glaucoma Surgery (Textbook)

      The advent of integrated intraoperative optical coherence tomography (i 2 OCT) has opened the door for safer and more complex surgeries in the retina and cornea. However, to limit its use to just two subspecialties within ophthalmology is an opportunity lost for many other subspecialties. Here, we describe the use of i 2 OCT in pediatric glaucoma surgery. It can be used to identify Schlemm’s canal, Barkan’s membrane, demonstrate the corneal pathology in Haab’s striae, and iris hypoplasia in cases of Axenfeld-Rieger anomaly. It can help identify drainage blebs that are filtering and those that are not ...

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    8. Optical Coherence Tomography in Retinopathy of Prematurity (Book Chapter)

      Optical Coherence Tomography in Retinopathy of Prematurity (Book Chapter)

      Retinopathy of prematurity is a vasoproliferative condition characterized by abnormal vascularization of the retina which may lead to tractional retinal detachment. Timely screening and treatment with laser and/or anti-vascular endothelial growth factor agents help prevent blindness. While bedside indirect ophthalmoscopy remains the gold standard for screening, optical coherence tomography has emerged as a new modality for understanding the pathogenesis of retinopathy of prematurity, providing in-vivo monitoring, and evaluating subclinical findings. This chapter provides an overview of optical coherence tomography in retinopathy of prematurity, including available models and adjustments in the neonatal population, differences between preterm, term and adult foveal ...

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    9. Clinical Applications of Optical Coherence Tomography Angiography (Textbook)

      Clinical Applications of Optical Coherence Tomography Angiography (Textbook)

      Optical coherence tomography angiography (OCTA) is a non-invasive, rapid, and 3-dimensional evaluation of retinal vasculature well-suited for the evaluation of the microvasculopathy of diabetes. It visualizes the key clinical features of diabetic retinopathy (DR), including microaneurysms, non-perfusion, neovascularization, and capillary dilation. Several studies quantifying non-perfusion metrics in DR have demonstrated significant correlation between levels of retinopathy with these metrics. Segmentation schema, projection artifacts, image resolution, and signal strength remain a challenge, and careful attention to these and other technical issues is required for understanding the application of quantitative OCTA in DR.

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    10. Diagnostics in Ocular Imaging (Textbook)

      Diagnostics in Ocular Imaging (Textbook)

      This book presents a new avenue in the field of ophthalmology and sheds light on the field of eye imaging. With the increasing availability of electronic devices and their important role in both personal and professional aspects of human life, there is a growing need for perfect vision. Ophthalmic imaging is a major tool for screening and documenting eye diseases in both medical and surgical fields of ophthalmology and is also of use for ophthalmologists around the globe. The number of eye-imaging devices has increased dramatically, however undiagnosed or poorly managed eye diseases remain a significant cause of ocular and ...

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    11. Atlas of Anterior Segment Optical Coherence Tomography (Textbook)

      Atlas of Anterior Segment Optical Coherence Tomography (Textbook)

      Atlas of Anterior Segment Optical Coherence Tomography is organized into comprehensive chapters on the following topics: fundamentals, technologies and technological differences among platforms, application of OCT, corneal OCT angiography, as well as case-based chapters. Numerous highly-detailed figures, illustrations and photographs make this an ideal resource for the corneal specialist seeking further instruction on this cutting-edge technology. The case-based chapters include such conditions as bowman dystrophies, trauma, cataract, glaucoma, sclera, refractive surgery, ocular infections, and are structured to facilitate the consultant surgeon by providing practical information applicable to practical cases in their practice.

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    12. Macular Surgery Current Practice and Trends (Textbook)

      Macular Surgery Current Practice and Trends (Textbook)

      Recent technological advances in the diagnosis of macular disorders have enhanced our understanding of these diseases. At the same time, advances in small-gauge vitrectomy instrumentation and techniques have improved the safety and efficiency of surgery, allowing macular conditions that would have otherwise resulted in blindness to be treated effectively, preserving patients’ sight. Macular surgery continues to evolve rapidly, thanks to exciting future technology trends. This book provides a detailed and up-to-date overview of the field. It begins with essential information on macular anatomy and pathophysiology, examination techniques, and surgical instrumentation. In turn, it discusses a broad range of disease processes ...

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    13. Atlas of Pathologic Myopia (Textbook)

      Atlas of Pathologic Myopia (Textbook)

      The choroid in high myopia is markedly thin compared to normal eyes. Choroidal thickness is negatively correlated with severity of myopic maculopathy from tessellated fundus to macular diffuse choroidal atrophy. However, there is no significant difference in choroidal thickness between eyes with macular diffuse choroidal atrophy and patchy choroidal atrophy. By using swept-source OCT, macular Bruch’s membrane defects in patchy atrophy and CNV-related macular atrophy have also been shown. Using receiver operating characteristic curve, the cut-off value of 56.5 μm for the nasal choroidal thickness (3000 μm from fovea) is able to predict peripapillary diffuse choroidal atrophy from ...

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    14. Advances in Ocular Imaging in Glaucoma (Textbook)

      Advances in Ocular Imaging in Glaucoma (Textbook)

      Serving as a practical guide to the ocular imaging modalities that are currently available to eye care providers for the care of glaucoma patients, this book provides information on advances in ocular imaging and their applications in the diagnosis and management of glaucoma. Each chapter introduces the imaging modality, highlight its strengths and weaknesses for clinical care, and discuss its integration into the clinical examination and decision-making process. The chapters also provide an in-depth description of the interpretation of images from each imaging modality. When appropriate, the chapters will summarize past and ongoing research and propose future research directions and ...

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    15. Advances in Optical Imaging Technique (Textbook)

      Advances in Optical Imaging Technique (Textbook)

      Optical imaging is a pillar in biomedical research from super-resolution microscopy to whole-body imaging in animal models. Optical imaging covers such a large field that it is difficult to decide what was the first medical application .Could it be said that the introduction of spectacles in 1270, in Florence, Italy was the first use of optical imaging in medicine? Or the introduction in 1590 of the compound microscope by the father and son team of Hans and Zacharias Janssen in the Netherlands? It is more likely that optical imaging (as understood by the general scientific community) and the application of ...

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    16. Atlas of Optical Coherence Tomography for Glaucoma (Textbook)

      Atlas of Optical Coherence Tomography for Glaucoma (Textbook)

      Atlas of Optical Coherence Tomography for Glaucoma is a case-based atlas intended to teach the reader how to interpret the results of OCT in glaucoma patients and glaucoma suspects. After a brief description of how OCT is used in particular situations, chapters depict actual case presentations from authors’ practices with legends that describe the case and how OCT is used to make the diagnosis of glaucoma or glaucoma progression. Emphasis is placed on where OCT can lead the clinician astray by providing false positive or false negative results resulting in misdiagnosis. The intention of the format is to make it ...

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    17. Technology in Practical Dermatology (Textbook)

      Technology in Practical Dermatology (Textbook)

      This book provides a complete overview on the latest available technologies in dermatology, while discussing future trends of this ever-growing field. This handy guide provides clinicians and researchers with a clear understanding of the advantages and challenges of laser and imaging technologies in skin medicine today. It also includes a section on imaging techniques for the evaluation of skin tumors, with chapters devoted to dermoscopy, in vivo and ex vivo reflectance confocal microscopy, high frequency ultrasound, optical coherence tomography, and a closing part on latest approaches to wound management. Completed by over 200 clinical images, Current Technology in Practical Dermatology ...

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    18. Optical Coherence Tomography and Its Non-medical Applications (Textbook)

      Optical Coherence Tomography and Its Non-medical Applications (Textbook)

      Optical coherence tomography (OCT) is a promising non-invasive non-contact 3D imaging technique that can be used to evaluate and inspect material surfaces, multilayer polymer films, fiber coils, and coatings. OCT can be used for the examination of cultural heritage objects and 3D imaging of microstructures. With subsurface 3D fingerprint imaging capability, OCT could be a valuable tool for enhanci...

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    19. Human Brain Imaging by Optical Coherence Tomography (Book Chapter)

      Human Brain Imaging by Optical Coherence Tomography (Book Chapter)

      The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light. Including 30 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead ...

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    20. Intraretinal fluid map generation in optical coherence tomography images (book chapter)

      Intraretinal fluid map generation in optical coherence tomography images (book chapter)

      The retina represents one of the most studied parts of the human body, thanks to its easy access for any ophthalmological study. It represents the main neurosensory part of the eye and, by its study, pathologies not only from the visual system but also from different body systems (like the neural system or vascular system) can be detected. Among the principal medical imaging modalities that are used to study the eye fundus and the retinal histological structures, the optical coherence tomography (OCT) has proven to be one of the most reliable techniques. It is widely used for the detection of ...

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    21. Diabetes and Fundus OCT: 1st Edition (Textbook)

      Diabetes and Fundus OCT: 1st Edition (Textbook)

      Diabetes and Fundus OCT brings together a stellar cast of authors who review the computer-aided diagnostic (CAD) systems developed to diagnose non-proliferative diabetic retinopathy in an automated fashion using Fundus and OCTA images. Academic researchers, bioengineers, new investigators and students interested in diabetes and retinopathy need an authoritative reference to bring this multidisciplinary field together to help reduce the amount of time spent on source-searching and instead focus on actual research and the clinical application. This reference depicts the current clinical understanding of diabetic retinopathy, along with the many scientific advances in understanding this condition. As the role of optical ...

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    22. Imaging Technologies and Transdermal Delivery in Skin Disorders (Textbook)

      Imaging Technologies and Transdermal Delivery in Skin Disorders (Textbook)

      Provides the latest information on imaging technologies and transdermal delivery in skin disorders This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work. Imaging Technologies and Transdermal Delivery in Skin Disorders starts by outlining the structural characteristics of skin and skin appendages ...

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    23. High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics (Textbook)

      High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics (Textbook)

      This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT , the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and

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    24. OCT and Imaging in Central Nervous System Diseases: The Eye as a Window to the Brain (Textbook)

      OCT and Imaging in Central Nervous System Diseases: The Eye as a Window to the Brain (Textbook)

      The second edition of OCT and Imaging in Central Nervous System Diseases offers updated state-of-the-art advances using optical coherence tomography (OCT) regrading neuronal loss within the retina. Detailed information on the OCT imaging and interpretation is provided for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. Covering disorders like multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia, readers will given insights into effects on the retina and the and optic nerve. Individual chapters are also devoted to OCT technique ...

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