1. Articles in category: Probes

    73-96 of 604 « 1 2 3 4 5 6 7 ... 24 25 26 »
    1. Surgical instrument and systems with integrated optical sensor

      Surgical instrument and systems with integrated optical sensor

      A surgical instrument has a surgical tool that has a proximal end and a distal end, and an optical sensor that has at least a portion attached to the surgical tool. The surgical tool has a portion that is suitable to provide a reference portion of the surgical tool, and the optical sensor has an end fixed relative to the reference portion of the surgical tool such that the reference portion of the surgical tool can be detected along with tissue that is proximate or in contact with the distal end of the surgical tool while in use.

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    2. Guarded imaging devices and methods

      Guarded imaging devices and methods

      An integrated therapeutic and imaging device that uses at least two balloons to provide a guarded zone that can be evacuated and replaced with a fluid that is sufficiently clear to permit optical coherence tomography (or even high resolution ultrasound) imaging that would otherwise be of poor quality or impossible. Methods of making and operating the imaging device to obtain clear, high quality images, as well as treating a patient's tissue with the device within a living body in association with obtaining an image of the patient's tissue, are included.

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    3. Optical probe and optical coherence tomography apparatus including the same

      Optical probe and optical coherence tomography apparatus including the same

      An optical probe for irradiating light onto a subject includes an optical path control unit configured to receive light from outside the optical probe, and change a path of the light within the optical probe; an optical path length control element configured to receive the light having the changed path from the optical path control unit, and change an optical path length of the light as the optical path control unit changes the path of the light; and an optical output unit configured to receive the light having the changed optical path length from the optical path length control element ...

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      Mentions: Samsung
    4. Adalimumab Microneedles in Healthy Volunteers

      Adalimumab Microneedles in Healthy Volunteers

      Adalimumab (Humira, AbbVie) is a highly effective treatment for a variety of auto-immune/auto-inflammatory diseases including juvenile idiopathic arthritis (JIA). Adalimumab works by binding to tumor necrosis factor alpha (TNF), hereby preventing its interaction with the TNF receptor. In the presence of complement, adalimumab can also lyse TNF-expressing cells. Adalimumab is administered via subcutaneous injection, which has the major drawback of being perceived as unpleasant and painful, especially during long term use for both adults and children. As subcutaneous administration may therefore eventually jeopardize treatment adherence, there is a clear need for less invasive alternatives to administer highly effective biological ...

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    5. Nano-optic endoscope for high-resolution optical coherence tomography in vivo

      Nano-optic endoscope for high-resolution optical coherence tomography in vivo

      Acquisition of high-resolution images from within internal organs using endoscopic optical imaging has numerous clinical applications. However, difficulties associated with optical aberrations and the trade-off between transverse resolution and depth of focus significantly limit the scope of applications. Here, we integrate a metalens, with the ability to modify the phase of incident light at subwavelength level, into the design of an endoscopic optical coherence tomography catheter (termed nano-optic endoscope) to achieve near diffraction-limited imaging through negating non-chromatic aberrations. Remarkably, the tailored chromatic dispersion of the metalens in the context of spectral interferometry is utilized to maintain high-resolution imaging beyond the ...

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    6. All-optical dual photoacoustic and optical coherence tomography intravascular probe

      All-optical dual photoacoustic and optical coherence tomography intravascular probe

      Intravascular imaging in percutaneous coronary interventions can be an invaluable tool in the treatment of coronary artery disease. It is of significant interest to provide molecular imaging contrast that is complementary to structural contrast provided by optical coherence tomography (OCT) and intravascular ultrasound imaging (IVUS). In this study, we developed a dual-modality intravascular imaging probe comprising a commercial OCT catheter and a high sensitivity fiber optic ultrasound sensor, to provide both photoacoustic (PA) and OCT imaging. With PA imaging, the lateral resolution varied from 18 µm to 40 µm; the axial resolution was consistently in the vicinity of 45 µm ...

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    7. Friction torque limiter for an imaging catheter

      Friction torque limiter for an imaging catheter

      The invention provides a frictional torque limiter assembly for an imaging core spinning in a patient's body. The torque limiter assembly torsionally isolates the imaging core from a motor that spins the imaging core. An interference fit between a slitted drive tube and a spacer tube acts as a clutch that allows a spinning imaging probe to slow or stop relative to the motor until the motor is stopped, thereby preventing an unsafe condition.

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      Mentions: Abbot
    8. Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model

      Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model

      Incorrect needle placement during an epidural block causes medical complications such as dural puncture or spinal cord injury. We propose a system combining an optical coherence tomography imaging probe with an automatic identification algorithm to objectively identify the epidural needle-tip position and thus reduce complications during epidural needle insertion. Eight quantitative features were extracted from each two-dimensional optical coherence tomography image during insertion of the needle tip from the skin surface to the epidural space. 847 in vivo optical coherence tomography images were obtained from three anesthetized piglets. The area under the receiver operating characteristic curve was used to quantify ...

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    9. Multi-channel optical coherence tomography probe for use in a medical procedure

      Multi-channel optical coherence tomography probe for use in a medical procedure

      A multi-channel optical coherence tomography probe for use in a medical procedure is provided. The probe comprises: a plurality of first optical fibers optically connectable to an OCT light source; a plurality of second optical fibers different from the plurality of first optical fibers; a scanning device comprising: an actuator configured to rotationally move the plurality of second optical fibers between a first position and a second position, relative to the plurality of first optical fibers; and, a mirror configured to, as the plurality of second optical fibers is moving rotationally, convey light from exit faces of the plurality of ...

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    10. Forward scanning-optical probes, circular scan patterns, offset fibers

      Forward scanning-optical probes, circular scan patterns, offset fibers

      An optical light scanning probe is presented, the probe comprising a handle, shaped for grasping by a user; a cannula, protruding from a distal portion of the handle with an outer diameter smaller than 20 gauge; an optical fiber with a distal fiber-portion off a probe-axis, configured to receive a light from a light-source at a proximal fiber-portion, and to emit the received light at the distal fiber-portion; a fixed beam forming unit, disposed at a distal portion of the cannula, configured to receive the light from the distal fiber-portion, and to deflect the received light toward a target region ...

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    11. MICRO-MOLDED Anamorphic Reflector Lens For Image Guided THERAPEUTIC/DIAGNOSTIC Catheters

      MICRO-MOLDED Anamorphic Reflector Lens For Image Guided THERAPEUTIC/DIAGNOSTIC Catheters

      A catheter system for optical coherence tomography includes an elongate catheter body, an optical fiber in the elongate catheter body, and an anamorphic lens assembly coupled with a distal end of the optical fiber. The optical fiber and the lens assembly are together configured to provide a common path for optical radiation reflected from a target and from a reference interface between the distal end of the optical fiber and the lens assembly

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    12. Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography

      Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography

      A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy (EM) is presented. The two modalities are physically co‐registered in a common‐path configuration. The instrument is enabled by a dedicated planar lightwave circuit with a footprint of only 1.1 x 19.5 mm 2 that provides akinetic axial OCT scanning at speeds up to 24 kHz. Lateral scanning is implemented through a low‐voltage MEMS mirror packaged with the axial scanner in a hermetic butterfly module. The OCT system, with a volume of only 80 x 27 x 14 ...

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    13. Dual-beam manually actuated distortion-corrected imaging (DMDI): two dimensional scanning with a single-axis galvanometer

      Dual-beam manually actuated distortion-corrected imaging (DMDI): two dimensional scanning with a single-axis galvanometer

      We recently demonstrated a new two-dimensional imaging paradigm called dual-beam manually actuated distortion-corrected imaging (DMDI). This technique uses a single mechanical scanner and two spatially separated beams to determine relative sample velocity and simultaneously corrects image distortions due to manual actuation. DMDI was first demonstrated using a rotating dual-beam micromotor catheter. Here, we present a new implementation of DMDI using a single axis galvanometer to scan a pair of beams in approximately parallel lines onto a sample. Furthermore, we present a method for automated distortion correction based on frame co-registration between images acquired by the two beams. Distortion correction is ...

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    14. In-Vitro Detection of Small Isolated Cartilage Defects: Intravascular Ultrasound Vs. Optical Coherence Tomography

      In-Vitro Detection of Small Isolated Cartilage Defects: Intravascular Ultrasound Vs. Optical Coherence Tomography

      This experimental work focused on the sensor selection for the development of a needle-like instrument to treat small isolated cartilage defects with hydrogels. The aim was to identify the most accurate and sensitive imaging method to determine the location and size of defects compared to a gold standard (µCT). Only intravascular ultrasound imaging (IVUS) vs. optical coherent tomography (OCT) were looked at, as they fulfilled the criteria for integration in the needle design. An in-vitro study was conducted on six human cadaveric tali that were dissected and submerged in saline. To simulate the natural appearance of cartilage defects, three types ...

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    15. Gradient Index Lens Assembly-Based Imaging Apparatus, Systems and Methods

      Gradient Index Lens Assembly-Based Imaging Apparatus, Systems and Methods

      <p id="p-0001" num="0000">In part, the disclosure relates to a lens assembly. The lens assembly can be used to direct light for sensing and imaging. In one embodiment, the lens assembly is a component of an intravascular data collection probe such as an optical coherence tomography probe. The lens assembly can include an optical fiber having a first diameter and a gradient index lens that includes a rod having a length L. The rod can include a substantial planar end and a polished end.

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      Mentions: Abbot
    16. Innovative Endoscopies to Be Clinically Used in the Near Future

      Innovative Endoscopies to Be Clinically Used in the Near Future

      In contrast to traditional single-lens endoscopies, recently introduced full-spectrum endoscopy (FUSE) scopes include multiple lenses providing a much wider field of view. In many studies, FUSE was shown to be feasible, effective, and safe, and FUSE colonoscopy yielded higher polyp (PDR), adenoma (ADR), and diverticular (DDR) detection rates than did traditional colonoscopy, without therapeutic failure or complications. Moreover, using FUSE gastroscopy, the prevalence of duodenal peri-ampullary diverticula (DPAD) in the general population could be analyzed without using ERCP. In the future, the next generation of modified FUSE system is expected to be useful in direct peroral cholangioscopy and in simultaneous ...

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    17. Common-path Optical Coherence Tomography using Bessel Beam from Negative Axicon Optical Fiber Tip

      Common-path Optical Coherence Tomography using Bessel Beam from Negative Axicon Optical Fiber Tip

      In this work a deep-seated negative axicon fiber tip (DSNA-FT) generating Bessel-Gauss beam is proposed as an optical probe for common-path optical coherence tomography (CPOCT) imaging. The axicon at the optical fiber tip is fabricated by etching the tip of a selective optical fiber in hydrofluoric acid under the influence of capillary action. The non-diffracting type quasi Bessel beam from the DSNA-FT having a long depth of field, ~0.7 mm, is used for CPOCT imaging of different type of samples i.e. sticky tape, fish scale, and rice grain. The CPOCT with unique and simple optical fiber probe has ...

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    18. Imaging Apparatus With Balloon And Shaped Tip

      Imaging Apparatus With Balloon And Shaped Tip

      Exemplary imaging apparatuses are described. Various imaging apparatuses may implement optical coherence tomography (OCT) and/or optical frequency domain imaging (OFDI) gastrointestinal tissue imaging methods and technologies. Furthermore, the imaging apparatuses may include a rotatable imaging element to scan a bodily lumen, such as the esophagus. The imaging element may be housed within an inflatable balloon. Still further, the imaging apparatuses may include a shaped tip. The shaped tip may aid in guiding an imaging apparatus through the esophagus, or other bodily lumen.

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    19. Review: Optical Scanning Probe for Optical Coherence Tomography

      Review: Optical Scanning Probe for Optical Coherence Tomography

      Optical coherence tomography (OCT) has become an important medical imaging modality. However, low penetration depth limits its application. Therefore, the optical scanning probe plays an important role in OCT systems for clinical applications. This article reviews OCT methodology and the mechanisms of an optical scanning probe. Recent developments of OCT probe and related clinical applications are summerized. Various OCT probe techniques (e.g., side imaging and forward imaging) have been used for measuring optical biopsy of various tissues. OCT probes for early diagnosis applications should be developed and combined with functional OCT modalities, such as Doppler OCT and polarization-sensitive OCT ...

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    20. Multimodality endoscopic optical coherence tomography and fluorescence imaging technology for visualization of layered architecture and subsurface microvasculature

      Multimodality endoscopic optical coherence tomography and fluorescence imaging technology for visualization of layered architecture and subsurface microvasculature

      Endoscopic imaging technologies, such as endoscopic optical coherence tomography (OCT) and near-infrared fluorescence, have been used to investigate vascular and morphological changes as hallmarks of early cancer in the gastrointestinal tract. Here we developed a high-speed multimodality endoscopic OCT and fluorescence imaging system. Using this system, the architectural morphology and vasculature of the rectum wall were obtained simultaneously from a Sprague Dawley rat in vivo . This multimodality imaging strategy in a single imaging system permits the use of a single imaging probe, thereby improving prognosis by early detection and reducing costs.

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    21. A System for Clinical Use of Endoscopic Optical Coherence Tomography

      A System for Clinical Use of Endoscopic Optical Coherence Tomography

      Introduction: Optical Coherence Tomography (OCT) allows non-invasive high-resolution imaging of tissues. With a penetration depth of a few millimeters it's possible to image the tympanic membrane and the close-by part of the tympanum, e.g. for diagnostics of otitis media and middle ear effusion. In the field of in vivo examination there are difficulties in access to the human tympanic membrane due to the narrow and curved external ear canal. We report a compact endoscopic OCT system for use in clinical research. Methods: We use a 3,5 mm endoscopic GRIN lens for video endoscopy and OCT. OCT is ...

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    22. Feature of The Week 04/27/2018: Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue

      Feature of The Week 04/27/2018: Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue

      The ability to visualize structure while simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double-clad fiber, including a thin layer of rare-earth-doped tellurite glass to enable temperature measurements. The high refractive index of the tellurite glass enables a common-path interferometer configuration for OCT, allowing easy exchange of probes for biomedical applications. The simultaneous imaging+sensing capability ...

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    23. Passively Driven Probe Based on Miniaturized Propeller for Intravascular Optical Coherence Tomography

      Passively Driven Probe Based on Miniaturized Propeller for Intravascular Optical Coherence Tomography

      Optical coherent tomography (OCT) has enabled clinical applications ranging from ophthalmology to cardiology that revolutionized in vivo medical diagnostics in the last few decades, and a variety of endoscopic probes have been developed in order to meet the needs of various endoscopic OCT imaging. We propose a passive driven intravascular optical coherent tomography (IV-OCT) probe in this paper. Instead of using any electrically driven scanning device, the probe makes use of the kinetic energy of the fluid that flushes away the blood during the intravascular optical coherence tomography imaging. The probe converts it into the rotational kinetic energy of the ...

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    73-96 of 604 « 1 2 3 4 5 6 7 ... 24 25 26 »
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