1. Articles in category: Probes

    241-264 of 441 « 1 2 ... 8 9 10 11 12 13 14 ... 17 18 19 »
    1. Microball lens integrated fiber probe for optical frequency domain imaging

      Microball lens integrated fiber probe for optical frequency domain imaging
      An integrated microball lens fiber catheter probe is demonstrated, which has better lateral resolution and longer working distance than a corresponding bare fiber probe with diverging beam for Fourier domain optical coherence tomography (FDOCT). Simulation results are shown to gain the effect of the distance between the microball lens and the bare fiber to the focusing plane and beam width. The freedom of modifying the working distance and lateral resolution is shown. This is achieved by changing the gap distance between the single-mode fiber and the microball lens within the packaged surgical needle catheter without using an additional beam expander ...
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    2. Scientists awarded grant to continue developing optical device for medical exams

      Scientists awarded grant to continue developing optical device for medical exams

      Primary-care physicians could be using a handheld device that combines the functions of several tools at once, all linked to massive data storage, within the decade. The National Institutes of Health have awarded a team led by the University of Illinois $5 million over five years — with a renewal options — to improve the UI's optical tomography tool. The handheld tool can scope and make video of ears, eyes, cervical tissue and skin with only the change of a tip, and enter the bloodstream with fiber cable attached. Professor Stephen A. Boppart of the Beckman Institute is the principal investigator ...

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    3. New Diagnostic Imaging Technologies in Nonvariceal Upper Gastrointestinal Bleeding

      New Diagnostic Imaging Technologies in Nonvariceal Upper Gastrointestinal Bleeding
      This article covers new endoscopic imaging modalities in nonvariceal upper gastrointestinal bleeding, such as Doppler ultrasound probe technology, endoscopic ultrasonography, color Doppler optical coherence tomography, and magnification endoscopy. A more in-depth discussion of these modalities and the published evidence supporting their use are included. Furthermore, the shift in focus from identification of conventional visual surface stigmata of recent hemorrhage to an assessment and understanding of subsurface blood flow as it relates to the bleeding lesion is discussed.
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    4. Optical coherence tomography / acoustic radiation force imaging probe

      Optical coherence tomography / acoustic radiation force imaging probe
      combined system and method synchronizes optical coherence tomography and acoustic radiation force for simultaneously imaging and mechanically displacing tissue in a patient as a detection and analytic tool. An endoscope is provided which has a piezoelectric element and an OCT scanner. The piezoelectric element generates the acoustic force to displace the tissue. The OCT scanner images the tissue and the system determines the mechanical displacement of the tissue. Cancer and arterial plaques can be recognized from the mechanical displacement of the tissue.
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    5. Depixelation of coherent fiber bundle endoscopy based on learning patterns of image prior

      Depixelation of coherent fiber bundle endoscopy based on learning patterns of image prior
      We present an iterative method of eliminating pixelation artifacts from an endoscopic image acquired from a coherent fiber bundle imager. Our proposed approach for decoupling the honeycomb effect from the obtained sample image was formulated by using the prior probability for an approximate Bayesian framework in which the ideal complete image can be estimated by maximizing the posterior probability from the observed image. The maximization of the posterior probability from the original mask image (the mirrored fiber bundle imager structure) and the observed image (the sample image of the United States Air Force chart) has been performed by learning the ...
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    6. Intravascular Optical Coherence Tomography System With Pressure Monitoring Interface And Accessories

      Intravascular Optical Coherence Tomography System With Pressure Monitoring Interface And Accessories
      An optical coherence tomography system and method with integrated pressure measurement. In one embodiment the system includes an interferometer including: a wavelength swept laser; a source arm in communication with the wavelength swept laser; a reference arm in communication with a reference reflector; a first photodetector having a signal output; a detector arm in communication with the first photodetector, a probe interface; a sample arm in communication with a first optical connector of the probe interface; an acquisition and display system comprising: an A/D converter having a signal input in communication with the first photodetector signal output and a ...
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    7. Multiphoton Fluorescence Microscopy with GRIN Objective Aberration Correction by Low Order Adaptive Optics

      Multiphoton Fluorescence Microscopy with GRIN Objective Aberration Correction by Low Order Adaptive Optics

      Graded Index (GRIN) rod microlenses are increasingly employed in the assembly of optical probes for microendoscopy applications. Confocal, two–photon and optical coherence tomography (OCT) based on GRIN optical probes permit in–vivo imaging with penetration depths into tissue up to the centimeter range. However, insertion of the probe can be complicated by the need of several alignment and focusing mechanisms along the optical path. Furthermore, resolution values are generally not limited by diffraction, but rather by optical aberrations within the endoscope probe and feeding optics. Here we describe a multiphoton confocal fluorescence imaging system equipped with a compact objective ...

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    8. Needle stylet with integrated optical fibers for spectroscopic contrast during peripheral nerve blocks

      Needle stylet with integrated optical fibers for spectroscopic contrast during peripheral nerve blocks
      The effectiveness of peripheral nerve blocks is highly dependent on the accuracy at which the needle tip is navigated to the target injection site. Even when electrical stimulation is utilized in combination with ultrasound guidance, determining the proximity of the needle tip to the target region close to the nerve can be challenging. Optical reflectance spectroscopy could provide additional information about tissues that is complementary to these navigation methods. We demonstrate a novel needle stylet for acquiring spectra from tissue at the tip of a commercial 20-gauge needle. The stylet has integrated optical fibers that deliver broadband light to tissue ...
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    9. Electrostatically driven image probe

      Electrostatically driven image probe
      The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including ultrasound and optical coherence tomography. The imaging probe uses electrostatic discharge for actuating a metalized cantilever which holds the end portion of imaging assembly which emits energy in the imaging probe device by holding the cantilever at a potential such that it is neither grounded or charged such that the only electrical path to ground is through a dissipative polymer forming part of the device which is enveloped by a wire or coil held at ground potential. A high voltage electrode attracts ...
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    10. Differential-phase polarization-sensitive optical coherence tomography system

      Differential-phase polarization-sensitive optical coherence tomography system
      A differential-phase polarization-sensitive optical coherence tomography system includes a polarized heterodyne interferometer for generating a reference beam to be reflected by a movable mirror unit, and a signal beam to be reflected by an imaging plane in a specimen. The interferometer further generates a first electrical signal output corresponding to first linear polarized waves of the reference and signal beams, and a second electrical signal output corresponding to second linear polarized waves of the reference and signal beams. A differential amplifier receives the first and second electrical signal outputs, and generates a differential signal output therefrom. A data acquisition unit ...
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    11. Catheters for optical coherence tomography

      Catheters for optical coherence tomography
      The objective of this review article is to overview technology, clinical evidence, and future applications to date optical coherence tomography (OCT) probes to yield the diagnostic purpose. We have reviewed the designing, construction and working of different categories of OCT probes developed for optical diagnostics having a potential for non invasive and improved detection of different types of cancer as well as other neoplasm. Rotational and balloon catheters, imaging needles and hand-held, linear scanning, multichannel, micro electro mechanical systems (MEMS) technology based, dynamic focusing, forward view imaging, and common path interferometer based probes have been discussed in details. The fiber ...
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    12. Design of a handheld optical coherence microscopy endoscope

      Design of a handheld optical coherence microscopy endoscope
      Optical coherence microscopy (OCM) combines coherence gating, high numerical aperture optics, and a fiber-core pinhole to provide high axial and lateral resolution with relatively large depth of imaging. We present a handheld rigid OCM endoscope designed for small animal surgical imaging, with a 6-mm diam tip, 1-mm scan width, and 1-mm imaging depth. X-Y scanning is performed distally with mirrors mounted to micro galvonometer scanners incorporated into the endoscope handle. The endoscope optical design consists of scanning doublets, an afocal Hopkins relay lens system, a 0.4 numerical aperture water immersion objective, and a cover glass. This endoscope can resolve ...
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    13. Optical coherence tomography device and measuring head

      Optical coherence tomography device and measuring head
      An optical coherence tomography device includes: a light source 16; a light splitting section 19 that splits light source light into reference light 19 and measuring light 28 with which a sample 22 is irradiated; an interfering section 19 that allows the measuring light 28 to interfere with the reference light 29 to generate interference light; a photodetectiong section 26 that measures interference light; a movable measuring head 201 that changes the irradiating position and/or direction, irradiated with the measuring light 28, by a motion of the measuring head 20; a mechanical quantity sensor 38 that measures the motion ...
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    14. Potential role of a hybrid intraoperative probe based on OCT and positron detection for ovarian cancer detection and characterization

      Potential role of a hybrid intraoperative probe based on OCT and positron detection for ovarian cancer detection and characterization
      Ovarian cancer has the lowest survival rate of the gynecologic cancers because it is predominantly diagnosed in the late stages due to the lack of reliable symptoms and efficacious screening techniques. A novel hybrid intraoperative probe has been developed and evaluated for its potential role in detecting and characterizing ovarian tissue. The hybrid intraoperative dual-modality device consists of multiple scintillating fibers and an optical coherence tomography imaging probe for simultaneously mapping the local activities of 18F-FDG uptake and imaging of local morphological changes of the ovary. Ten patients were recruited to the study and a total of 18 normal, abnormal ...
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    15. MEMS-Based Endoscopic Optical Coherence Tomography

      MEMS-Based Endoscopic Optical Coherence Tomography
      Early cancer detection has been playing an important role in reducing cancer mortality. Optical coherence tomography (OCT), due to its micron-scale resolution, has the ability to detect cancerous tissues at their early stages. For internal organs, endoscopic probes are needed as the penetration depth of OCT is about 1–3 mm. MEMS technology has the advantages of fast speed, small size, and low cost, and it has been widely used as the scanning engine in endoscopic OCT probes. Research results have shown great potential for OCT in endoscopic imaging by incorporating MEMS scanning mirrors. Various MEMS-OCT designs are introduced, and ...
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    16. Nano-sensitizers for multi-modality optical diagnostic imaging and therapy of cancer

      Nano-sensitizers for multi-modality optical diagnostic imaging and therapy of cancer
      We report novel bioconjugated nanosensitizers as optical and therapeutic probes for the detection, monitoring and treatment of cancer. These nanosensitisers, consisting of hypericin loaded bioconjugated gold nanoparticles, can act as tumor cell specific therapeutic photosensitizers for photodynamic therapy coupled with additional photothermal effects rendered by plasmonic heating effects of gold nanoparticles. In addition to the therapeutic effects, the nanosensitizer can be developed as optical probes for state-of-the-art multi-modality in-vivo optical imaging technology such as in-vivo 3D confocal fluorescence endomicroscopic imaging, optical coherence tomography (OCT) with improved optical contrast using nano-gold and Surface Enhanced Raman Scattering (SERS) based imaging and bio-sensing ...
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    17. High resolution optical coherence tomography based imaging for intraluminal and interstitial use implemented with a reduced form factor

      High resolution optical coherence tomography based imaging for intraluminal and interstitial use implemented with a reduced form factor
      Mechanically robust minimal form factor OCT probes suitable for medical applications such as needle biopsy, intraluminal and intravascular imaging are achieved in part by employing compound lenses with some or all of the optical elements, including an optical fiber, to be thermally fused in tandem. To achieve a desired working distance without increasing a diameter of the optics assembly, a spacer can be disposed between the optical fiber and focusing optics. The compound lens configuration can achieve higher transverse resolution compared to a single lens at a desired working distance without increasing the probe diameter. In exemplary needle biopsy embodiments ...
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    18. Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging

      Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging

      We have developed a miniature integrated optical coherence tomography (OCT) ultrasound (US) probing system for intravascular imaging applications. In the OCT probe, the light coming out of a single mode fiber is focused by a gradient-index lens and then reflected by a right-angle prism from the side of the probe into the sample. It was combined with a 35 MHz PMN-PT side-viewing ultrasound transducer to obtain the ultrasound image as well. The OCT and ultrasound probes were integrated as a single probe to obtain OCT and ultrasound images simultaneously. The integrated probe has an outer diameter of 0.69 mm ...

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    19. Optical catheter configurations combining raman spectroscopy with optical fiber-based low coherence reflectometry

      Optical catheter configurations combining raman spectroscopy with optical fiber-based low coherence reflectometry
      The present invention provides apparatuses and methods for sample analysis, such as tissue analysis, that integrate high wavenumber (HW) Raman spectroscopy for chemical composition analysis and optical coherence tomography (OCT) to provide depth and morphological information. The invention also provides side-viewing optical probes that are based on a single double clad optical fiber for performing the combined HW Raman spectroscopy and OCT. Intravascular catheter embodiments and related vascular diagnostic methods are also provided.
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    20. System and method for reconstruction of the human ear canal from optical coherence tomography scans

      System and method for reconstruction of the human ear canal from optical coherence tomography scans
      A method for reconstructing an ear canal from optical coherence tomography (OCT) scan data of an ear comprises extracting frame numbers and line numbers of interference intensities corresponding to one or more markers on an OCT scan guide, receiving reference frame numbers and lines numbers for one or more markers, determining a starting position and direction for the OCT ear scan from the ear scan marker frame and line numbers and the reference marker frame and line numbers, for each scan line, finding a pixel number of a maximum interference intensity value, and determining an offset distance of said pixel ...
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      Mentions: Siemens
    21. Two-dimensional scanning probe driven by a solenoid-based single actuator for optical coherence tomography

      Two-dimensional scanning probe driven by a solenoid-based single actuator for optical coherence tomography
      We propose the two-dimensional scanning probe operating with a single actuator, which is thought useful as a sample probe for optical coherence tomography (OCT). The probe was designed to use a single-body lensed fiber cantilever loaded with an iron-bead and driven by a single-solenoid actuator. Elliptic spiral trace patterns were achieved using off-axis magnetic fields of the solenoid. A three-dimensional OCT image was obtained for a scanning area of 3.8 mm×3.4 mm at an acquisition speed of 16.7 s/V. Up to 27 Hz B-scan rate, the proposed probe worked well, and 1000 A-scans were made ...
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    22. Method and system for producing tomographic image by optical tomography with processing of interference light signals

      Method and system for producing tomographic image by optical tomography with processing of interference light signals
      When reflection light, reflected from a measurement target that has been irradiated with measurement light in such a manner to scan the measurement target, and reference light are combined in each wavelength sweep, interference light is detected as interference signals. When a thinning region in which the interference signals obtained by detecting the interference light in each wavelength sweep are thinned so that the interference signals that are used to produce the tomographic image remain is set, thinning is performed on the plurality of interference signals in the thinning region. Light intensity information about the measurement target in the thinning ...
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    23. Multisensor probe for tissue identification

      Multisensor probe for tissue identification
      A multisensor probe for continuous real-time tissue identification. The multisensor probe includes a tissue penetrating needle, a plurality of sensors useful in characterizing tissue and a position sensor to measure the depth of the needle into the tissue being diagnosed. The sensors include but are not limited to an optical scattering and absorption spectroscopy sensor, an optical coherence domain reflectometry sensor, an electrical impedance sensor, a temperature sensor, a pO.sub.2 sensor, a chemical sensor and other sensors useful in identifying tissue. The sensors may take the form of a plurality of optical fibers extending through said needle. A ...
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      Mentions: Luiz B. Da Silva
    241-264 of 441 « 1 2 ... 8 9 10 11 12 13 14 ... 17 18 19 »
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    1. (1 articles) Johns Hopkins University
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    1. (1 articles) Guillermo J. Tearney
    2. (1 articles) Michalina J. Góra
    3. (1 articles) Xuan Liu
    4. (1 articles) Norman S. Nishioka
    5. (1 articles) Jin U. Kang
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