1. Articles in category: Probes

    241-264 of 390 « 1 2 ... 8 9 10 11 12 13 14 ... 15 16 17 »
    1. Optical coherence tomography apparatus and methods

      Optical coherence tomography apparatus and methods
      In one aspect, the invention relates to an imaging probe. The imaging probe includes an elongate body having a proximal end and distal end, the elongate body adapted to enclose a portion of a slidable optical fiber, the optical fiber having a longitudinal axis; and a first optical assembly attached to a distal end of the fiber. The first optical assembly includes a beam director adapted to direct light emitted from the fiber to a plane at a predetermined angle to the longitudinal axis, a linear actuator disposed at the proximal portion of the elongated body, the actuator adapted to ...
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    2. Construction and test of a GRIN-based optical objective

      Construction and test of a GRIN-based optical objective
      Optical fibres with their unique ability to transport light even in a coherent way (fibre bundles) and the possibility to build small volume optical pieces (Graded Index Fibres, GRIN) have a dominant role in the assembly of probes and objectives for microscopy applications requiring noninvasive and flexible operation in small and crowded spaces (in vivo microscopy, endoscopy, inspection). Nowadays, even complex observing procedures like confocal, two-photon and optical coherence tomography can be approached with fibres, making possible in vivo applications and also in place decision and processing. We present here a series of analytical simulations and practical tests made on ...
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    3. Rotating catheter probe using a light-drive apparatus

      Rotating catheter probe using a light-drive apparatus
      The invention is a rotating tip catheter-imaging probe where electromagnetic energy is delivered to the distal end of a catheter and converted to mechanical energy using a light drive apparatus. The mechanical energy is then used to rotate a mirror that redirects light in fixed pattern on a sample. The rotating element of the light drive apparatus contains vanes, which rotate about an axis and positioned with bearings to minimize friction. A chamber encompasses the rotating element and is set to a vacuum pressure. The rotational speed of the catheter tip can be controlled by varying the optical power delivered ...
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    4. Microfabricated endoscopic probe integrated MEMS micromirror for optical coherence tomography bioimaging

      Microfabricated endoscopic probe integrated MEMS micromirror for optical coherence tomography bioimaging
      In this paper, we present a miniaturized endoscopic probe, consisted of MEMS micromirror, silicon optical bench (SiOB), grade index (GRIN) lens, single mode optical fiber (SMF) and transparent housing, for optical coherence tomography (OCT) bioimaging. Due to the use of the MEMS micromirror, the endoscopic OCT system is highly suitable for non-invasive imaging diagnosis of a wide variety of inner organs. The probe engineering and proof of concept were demonstrated by obtaining the two-dimensional OCT images with a cover slide and an onion used as standard samples and the axial resolution was around 10µm.
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    5. Mini-scope for multi-directional imaging

      Mini-scope for multi-directional imaging
      A mini-scope for multi-directional imaging is disclosed. The mini-scope includes an elongated mini-scoped body. An emissions aperture is disposed on the distal end of the elongated mini-scope body, which can be configured to emit a beam of optical energy propagating through a flexible optical conductor. A selective mirror is also positioned at the distal end of the elongated mini-scope body and is configured to selectively pass or reflect the beam of optical energy based on the optical characteristics of the beam. A SSID is further disposed on the distal end of the elongated mini-scope body for imaging illumination reflected by ...
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    6. Optical design of a line-focused forward-viewing scanner for optical coherence tomography

      Optical design of a line-focused forward-viewing scanner for optical coherence tomography
      We report an optical design of a line-focused forward-viewing optical coherence tomography (OCT) scanner for high-speed endoscopic imaging. To avoid a complex lens system, an off-axis cylindrical mirror is used for focusing the line illumination onto the sample surface. Because of its insensitivity to the broadband spectrum, the mirror-focused scanner improves the image quality compared to a lens-focused scanner. In this work, a feasibility study is carried out on the use of a reflective-optics-focused line scanner in OCT imaging, instead of the traditional refractive optics scanner. The Strehl ratio, chromatic focal shift, and field analysis were carried out for a ...
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    7. Apparatus of measuring glucose concentration by using optical coherence tomography and method of operating the apparatus

      Apparatus of measuring glucose concentration by using optical coherence tomography and method of operating the apparatus
      Disclosed is an apparatus and method for measuring glucose concentration by using Optical Coherence Tomography (OCT), and more particularly, an apparatus and method for increasing the blood volume around a measurement part by using a blood concentrating device and noninvasively measuring glucose concentration of the measuring portion by using OCT. A glucose concentration measuring apparatus and method using OCT according to the invention can noninvasively measure glucose concentration by using OCT and help a user to easily measure glucose concentration.
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    8. Common path systems and methods for frequency domain and time domain optical coherence tomography using non-specular reference reflection and a delivering device for optical radiation with a partially optically transparent non-specular reference reflector

      Common path systems and methods for frequency domain and time domain optical coherence tomography using non-specular reference reflection and a delivering device for optical radiation with a partially optically transparent non-specular reference reflector
      Provided are common path frequency domain and time domain OCT systems and methods that use non-specular reference reflection for obtaining internal depth profiles and depth resolved images of samples. Further provided is a delivering device for optical radiation, preferably implemented as an optical fiber probe with a partially optically transparent non-specular reflector placed in the vicinity of an associated sample. High frequency fringes are substantially reduced and a stable power level of the reference reflection is provided over the lateral scanning range. The partially optically transparent non-specular reflector is implemented as a coating placed on the interior surface of the ...
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    9. New collaboration targets skin cancer with hybrid imaging probe

      New collaboration targets skin cancer with hybrid imaging probe

      A new collaboration between researchers at King’s Health Partners Academic Health Sciences Centre and an innovative British company is targeting skin cancer with a new type of imaging probe. The £98,500 research project has received 75% funding through a National Institute for Health Research (NIHR) Invention for Innovation ‘i4i’ grant awarded to the partners, Guy’s and St Thomas’ NHS Foundation Trust, King’s College London and Michelson Diagnostics Ltd.   The aim of the project is to develop and test a hybrid imaging probe that combines the advantages of Michelson Diagnostics’ novel Multi-Beam OCT (Optical Coherence Tomography) probe ...

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    10. OCT probe for eliminating ghost images

      OCT probe for eliminating ghost images
      An OCT probe has a sheath to be inserted into a subject; and an optical system within the sheath, for changing the direction of light which propagates from a light source through an optical fiber to irradiate the light onto the subject through a transparent portion of the sheath, and for reflecting the light beam, which is reflected by the subject, to guide the light into the optical fiber. A light output surface, for causing the light to be output from the reflecting surface in a direction obliquely inclined with respect to the inner surface of the sheath, and a ...
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    11. High-resolution coregistered intravascular imaging with integrated ultrasound and optical coherence tomography probe

      High-resolution coregistered intravascular imaging with integrated ultrasound and optical coherence tomography probe
      We report an integrated ultrasound (US) and optical coherence tomography (OCT) probe and system for intravascular imaging. The dual-function probe is based on a 50 MHz focused ring US transducer, with a centric hole for mounting OCT probe. The coaxial US and light beams are steered by a 45° mirror to enable coregistered US/OCT imaging simultaneously. Lateral resolution of US is improved due to focused ultrasonic beam. Mirror effects on US were investigated and in vitro imaging of a rabbit aorta has been carried out. The combined US-OCT system demonstrated high resolution in visualizing superficial arterial structures while retaining ...
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    12. Endoscopic cross-polarization spectrometer as an instrument for puncture diagnostics

      Endoscopic cross-polarization spectrometer as an instrument for puncture diagnostics
      A modification of the polarization reflection spectroscopy method is proposed with the use of a polarizationmaintaining singlemode fiber. The choice of the fiber made it possible to create an optimal self consistent system for the illumination of a biological tissue and the reception of scattered radiation and to cre ate a probe compatible with any endoscopic equipment. The first clinical results of diagnosing tumor diseases with the created instrument showed that it is possible to determine the tumor–norm boundary, which is very important for organpreserving operations. All of the results obtained by this method agree well ...
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    13. Semi-resonant operation of a fiber-cantilever piezotube scanner for stable optical coherence tomography endoscope imaging

      Semi-resonant operation of a fiber-cantilever piezotube scanner for stable optical coherence tomography endoscope imaging
      A forward-view optical coherence tomography (OCT) scanning catheter has been developed based on a fiber-cantilever piezotube scanner by using a semi-resonant scan strategy for a better scan performance. A compact endoscope catheter was fabricated by using a tubular piezoelectric actuator with quartered electrodes in combination with a resonant fiber cantilever. A cantilever weight was attached to the fiber cantilever to reduce the resonance frequency down to 63 Hz, well in the desirable range for Fourier-domain OCT. The resonant-cantilever scanner was driven at semi-resonance frequencies that were well out of the resonance peak but within a range of partial resonance. This ...
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    14. Flexible Curled Optical Cord for Bending-Insensitive Optical Imaging Delivery

      Flexible Curled Optical Cord for Bending-Insensitive Optical Imaging Delivery

      In the application of optical imaging technologies to the biomedical field, the flexible optical cord is one of the key components used to deliver the reflected optical signal from the internal biological tissue to the biomedical imaging system. However, the conventional optical fibers suffer from a critical wiring limitation, which results in severe power losses under a small bending radius that is less than a few centimeters. In this paper, we demonstrate that holey optical fibers with 18 air holes in cladding have negligible bending loss under a minimum bending radius of 3 mm. Excellent bending insensitivity of the holey ...

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    15. Multi-Function Optical Probe System For Medical And Veterinary Applications (Wo 2010/104752)

      Multi-Function Optical Probe System For Medical And Veterinary Applications (Wo 2010/104752)
      A device includes a handpiece having a probe tip disposed at an end thereof, and, connected to the handpiece such that, at the probe tip, a functionality of each is provided, a plurality of probes. The probes may include an optical coherence tomography (OCT) probe, an endoillumination probe, a laser therapy probe, an ultrasound imaging probe, an electrocautery probe, an RF ablation probe, a cryosurgical probe, an irrigator, and/or a mechanical probe.
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    16. Surgical microscope having an OCT-system

      Surgical microscope having an OCT-system
      A surgical microscope (100) has viewing beams (109a, 109b) passing through a microscope imaging optic which includes a microscope main objective system (101) having a magnification system of variable magnification. The microscope imaging optic transposes a convergent viewing beam (109a, 109b) from the object region (114) into a parallel beam. The surgical microscope includes an OCT-system (120) for examining the object region (114). The OCT-system (120) makes available an OCT-scanning beam (190) which is guided through the microscope imaging optic.
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    17. Method and apparatus for measurement of optical properties in tissue

      Method and apparatus for measurement of optical properties in tissue
      A method of analyzing tissue includes inserting a radiation source into tissue, impinging radiation upon the tissue, obtaining a sample signal of the radiation that impinges upon the tissue, and determining a refractive index of the tissue from the sample signal. The method may also include determining at least one other optical property of the tissue. The method may provide for identifying tissue as part of a biopsy method. A device for analyzing tissue may include a low-coherence interferometer and a probe optically coupled to the interferometer, where the probe includes a radiation source.
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    18. Robust High-Resolution Fine OCT Needle for Side-Viewing Interstitial Tissue Imaging

      Robust High-Resolution Fine OCT Needle for Side-Viewing Interstitial Tissue Imaging
      Fine optical coherence tomography (OCT) imaging needles that can be integrated with a standard biopsy needle have been developed with a new optics design to improve the optical quality and mechanical robustness, where a fiber-optic lens (that is spliced to a single-mode fiber) and a microreflector are encased within a microglass tube. The design also minimizes the cylindrical lens effect induced by the glass tube and eases the needle assembly process. Real-time cross-sectional OCT imaging of various tissue samples were performed ex vivo using the miniature-imaging needle along with a 1300-nm swept-source OCT system. The preliminary results demonstrate the improved ...
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    19. Endoscopic Functional Fourier Domain Common-Path Optical Coherence Tomography for Microsurgery

      Endoscopic Functional Fourier Domain Common-Path Optical Coherence Tomography for Microsurgery
      A single-arm interferometer-based optical coherence tomography (OCT) system known as common-path OCT (CP-OCT) is rapidly progressing towards practical application. Due in part to the simplicity and robustness of its design, Fourier domain CP-OCT (FD-CP-OCT) offers advantages in many endoscopic sensing and imaging applications. FD-CP-OCT uses simple, interchangeable fiber optic probes that are easily integrated into small and delicate surgical tools. The system is capable of providing not only high-resolution imaging but also optical sensing. Here, we report progress towards practical application of FD-CP-OCT in the setting of delicate microsurgical procedures such as intraocular retinal surgery. To meet the challenges presented ...
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    20. In-vivo dynamic characterization of microneedle skin penetration using optical coherence tomography

      In-vivo dynamic characterization of microneedle skin penetration using optical coherence tomography
      The use of microneedles as a method of circumventing the barrier properties of the stratum corneum is receiving much attention. Although skin disruption technologies and subsequent transdermal diffusion rates are being extensively studied, no accurate data on depth and closure kinetics of microneedle-induced skin pores are available, primarily due to the cumbersome techniques currently required for skin analysis. We report on the first use of optical coherence tomography technology to image microneedle penetration in real time and in vivo. We show that optical coherence tomography (OCT) can be used to painlessly measure stratum corneum and epidermis thickness, as well as ...
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    21. Multimodal Depth-Resolving Endoscope

      Multimodal Depth-Resolving Endoscope
      A fiber-optic multimodal multi-spectral (MS), Optical Coherence Tomography (OCT), photoacoustic (PA) endoscope with beam scanning by a two-dimensional Microelectromechanical systems (MEMS) scanner present in the endoscopic head, combined in a synergetic way in a single endoscopic system. The PA, OCT and MS light sources are coupled to the endoscopic head through an optical switcher. Using a single optical endoscopic head and an electro-optical switch the endoscope of the invention is capable of sequential or parallel MS, OCT and PA imaging. The endoscope provides real-time imaging with a rate of 5 to 60 frames per second for each of the three ...
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    22. Miniature Non-MEMS Scanner For Small Size Imaging Systems

      Miniature Non-MEMS Scanner For Small Size Imaging Systems
      The SMALLEST available non-MEMS Resonant Scanner currently on the market was developed by Electro-Optical Products Corp. is a miniature electromagnetically driven moving mirror device (0.9 x 0.5 x 0.4 inches), which deflects a light beam with a continuous sinusoidal motion. EOPC's technology offers 6 mm diameter, 7x7 mm and 12x7 mm size mirrors, with an optical scanning angle up to 50°, and a fixed-frequency scanning range from 100 to 1000 Hz, fixed at any one value within the range. AGC type driver provides: •both sine wave and TTL level square wave reference signals •trimpot control to ...
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    23. System and method for identifying tissue using low-coherence interferometry

      System and method for identifying tissue using low-coherence interferometry
      An apparatus for needle biopsy with real time tissue differentiation using one dimensional interferometric ranging imaging, comprising a biopsy device having a barrel and a needle, an optical fiber inserted in the needle, and a fiber optic imaging system connected to the optical fiber. The imaging system obtains images and compares the optical properties and patterns to a database of normalized tissue sample images to determine different tissue types. The physician performing the biopsy obtains feedback via a feedback unit associated with the biopsy device and which is connected to the imaging system. The feedback unit can provide visual, audible ...
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    24. Interference objective for annular test surfaces

      Interference objective for annular test surfaces
      An apparatus including: an interferometric objective comprising a beam splitter surface configured to separate input light into test light and reference light, and a reference surface configured to receive the reference light and direct it back to the beam splitter surface, which is configured to recombine the reference light with test light reflected from a test surface, the interferometric objective further comprising one or more optical elements positioned in the path of the input light and having positive or negative optical power, wherein the reference surface is curved and defines a window to pass the input light towards the beam ...
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      Mentions: Zygo
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    1. (1 articles) Xiang Li
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