1. Articles in category: Probes

    1-24 of 450 1 2 3 4 ... 17 18 19 »
    1. Bimodal endoscopic probe combining white-light microscopy and optical coherence tomography

      Bimodal endoscopic probe combining white-light microscopy and optical coherence tomography

      We present a novel bimodal endoscopic imaging probe that can simultaneously provide full-field white-light video microscopy and confocal optical coherence tomography (OCT) depth scans. The two modalities rely on spectrally separated optical paths that run partially in parallel through a micro-optical bench system, which has a cross-section of only 2    mm × 2.76    mm and is realized via standard silicon micromachining techniques. With a numerical aperture of 0.061, the video modality has a resolution and field of view of 9.3 and 1240    μm × 1080    μm , respectively. The resolution is limited by the pixel spacing of the coherent fiber ...

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    2. Combination optical and ultrasonic imaging of an eye

      Combination optical and ultrasonic imaging of an eye

      A method and apparatus are disclosed for integrating optical coherence tomography (OCT) and very high frequency ultrasound (VHFU) imaging systems. An OCT probe and reference arm are mounted along with an ultrasound probe on a carriage capable of rotational, linear, and/or arcuate motion. The probe carriage may be immersed in water or other suitable medium. The OCT and VHFU probes move about the cornea surface such that the probe axes are substantially perpendicular relative to the cornea surface throughout a scan. The probes are able to be scanned in an arcuate path across the entire cornea surface. The method ...

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    3. Imaging probes and associated devices, systems, and methods utilizing speaker actuators

      Imaging probes and associated devices, systems, and methods utilizing speaker actuators

      Devices, systems, and methods that utilize a speaker to impart motion to an optical fiber positioned within an imaging probe are provided. In some embodiments, an ophthalmic imaging apparatus comprises an optical probe having a handle sized and shaped for handheld grasping by a user; and a cannula coupled to the handle, the cannula sized and shaped for insertion into an eye to be treated; an optical fiber positioned at least partially within the optical probe, the optical fiber configured to receive an imaging light from an imaging light source and guide the imaging light to an optical element positioned ...

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    4. Spectrally encoded miniature endoscopic imaging probe

      Spectrally encoded miniature endoscopic imaging probe

      A spectrally encoded endoscopic probe having high resolution and small diameter comprising at least one flexible optical fiber; an energy source; a grating through which said energy is transmitted such that the energy spectrum is dispersed; a lens for focusing the dispersed energy spectrum onto a sample such that the impingement spot for each wavelength is a separate position on the sample, the wavelength spectrum defining a wavelength encoded axis; means for mechanically scanning the sample with focused energy in a direction perpendicular to the wavelength encoded axis; a means for receiving energy reflected from the sample; and, a means ...

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    5. Imaging probes and associated devices, systems, and methods utilizing lever arm actuators

      Imaging probes and associated devices, systems, and methods utilizing lever arm actuators

      Devices, systems, and methods that utilize a mechanical structure, such as a lever arm or a flexure mechanism, and an electrically energizable member, such as an actuator, to impart motion to an optical fiber positioned within an imaging probe are provided. In some embodiments, an ophthalmic imaging probe can include a handle; a cannula coupled to the handle; an optical fiber positioned at least partially within the handle and the cannula, the optical fiber configured to receive an imaging light from an imaging light source and guide the imaging light to an optical element positioned within a distal portion of ...

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    6. Optical deflection element and optical deflection device

      Optical deflection element and optical deflection device

      An optical deflection element is provided with a substrate; an optical waveguide film made of an electro-optic medium, and constituting an optical waveguide formed on the substrate; a first electrode pair disposed on an incident side of the optical waveguide film at a position facing a film thickness direction of the optical waveguide film, and configured to deflect a light beam transmitting through the optical waveguide film in an in-plane direction of the optical waveguide film in accordance with a first applied voltage; and a second electrode pair disposed on an output side of the optical waveguide film at a ...

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      Mentions: Panasonic
    7. Active depth-guding handheld micro-forceps for membranectomy based on CP-SSOCT

      Active depth-guding handheld micro-forceps for membranectomy based on CP-SSOCT

      In this study, we demonstrate a handheld motion-compensated micro-forceps system using common-path swept source optical coherence tomography with highly accurate depth-targeting and depth-locking for Epiretinal Membrane Peeling. Two motors and a touch sensor were used to separate the two independent motions: motion compensation and tool-tip manipulation. A smart motion monitoring and guiding algorithm was devised for precise and intuitive freehand control. Ex-vivo bovine eye experiments were performed to evaluate accuracy in a bovine retina retinal membrane peeling model. The evaluation demonstrates system capabilities of 40 um accuracy when peeling the epithelial layer of bovine retina.

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    8. A 2-axis Polydimethylsiloxane (PDMS) based electromagnetic MEMS scanning mirror for optical coherence tomography

      A 2-axis Polydimethylsiloxane (PDMS) based electromagnetic MEMS scanning mirror for optical coherence tomography

      Optical coherence tomography (OCT) is a noninvasive imaging tool for visualizing cross-sectional images of biological tissues on a microscale. Various microelectromechanical system (MEMS) techniques have been applied to OCT for endoscopic catheters and handheld probes. Despite having several advantages such as compact sizes and high speeds for real-time imaging, the complexities of the fabrication processes and relatively high costs were bottlenecks for fast clinical translation and commercialization of the earlier MEMS scanners. To overcome these issues, we developed a 2-axis polydimethylsiloxane (PDMS)-based electromagnetic MEMS scanning mirror based on flexible, cost-effective, and handleable PDMS. The size of this MEMS scanner ...

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    9. Optical coherence tomography probe design for reduced artifact generation and manufacturability

      Optical coherence tomography probe design for reduced artifact generation and manufacturability

      Many fiber based probes used in Optical Coherence Tomography (OCT) are comprised of a spacer, GRIN lens, fiber, and a microprism. This design form suffers from many material interfaces, which induce back reflections into the sample arm of the interferometer. With so many interfaces, these probes can produce artifacts in the system’s imaging window. We present a design which has just two interfaces to minimize image artifacts. The two components of this design are the fiber endface and a reflective optic. With optimization, these two components can produce back reflections below -90dB which will minimize image artifacts. This will ...

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      Mentions: Corning
    10. Interferometric force sensor for surgical instruments

      Interferometric force sensor for surgical instruments

      A surgical tool system according to an embodiment of the current invention includes a surgical tool, and an interferometry system optically coupled to the surgical tool. The surgical tool includes a body section, a sensor section at least one of attached to or integral with the body section, and a surgical section at least one of attached to or integral with the sensor section at an opposing end of the sensor section from the body section. The sensor section comprises an interferometric optical sensor defining a reference distance that changes in response to at least one of a force or ...

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    11. Design and fabrication of an optical probe with a phase filter for extended depth of focus

      Design and fabrication of an optical probe with a phase filter for extended depth of focus

      The trade-off between spot size and depth of focus (DOF) often limits the performance of optical systems, such as optical coherence tomography and optical tweezers. Although researchers have proposed various methods to extend the DOF in free-space optics, many are difficult to implement in miniaturized optical probes due to space limitations. In this study, we present an optical probe with an extended DOF using a binary phase spatial filter (BPSF). The BPSF pattern was fabricated on the distal tip of an optical probe with a diameter of 1 mm by replica molding soft lithography, which can be easily implemented in ...

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    12. Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy

      Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy

      Optical coherence tomography (OCT) is an optical diagnostic modality that can acquire cross-sectional images of the microscopic structure of the esophagus, including Barrett’s esophagus (BE) and associated dysplasia. We developed a swallowable tethered capsule OCT endomicroscopy (TCE) device that acquires high-resolution images of entire gastrointestinal (GI) tract luminal organs. This device has a potential to become a screening method that identifies patients with an abnormal esophagus that should be further referred for upper endoscopy. Currently, the characterization of the OCT-TCE esophageal wall data set is performed manually, which is time-consuming and inefficient. Additionally, since the capsule optics optimally focus ...

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    13. Rotational distortion correction in endoscopic optical coherence tomography based on speckle decorrelation

      Rotational distortion correction in endoscopic optical coherence tomography based on speckle decorrelation

      We present a new technique for the correction of nonuniform rotation distortion in catheter-based optical coherence tomography (OCT), based on the statistics of speckle between A-lines using intensity-based dynamic light scattering. This technique does not rely on tissue features and can be performed on single frames of data, thereby enabling real-time image correction. We demonstrate its suitability in a gastrointestinal (GI) balloon-catheter OCT system, determining the actual rotational speed with high temporal resolution, and present corrected cross-sectional and en face views showing significant enhancement of image quality.

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    14. Method and system for optically evaluating proximity to the inferior alveolar nerve in situ

      Method and system for optically evaluating proximity to the inferior alveolar nerve in situ

      A low coherence interferometry probe system for evaluating proximity to a tissue layer, comprising a low coherence light source, an excitation optical fiber to bring the low coherence excitation light near the tissue layer and a collection optical fiber for capturing back-scattered light from the tissue layer. The probe system comprises an interferometry sub-system and a processor for evaluating a distance to the tissue layer. There is also provided a spectral absorption probe system for evaluating proximity to an artery, comprising a light source excitation light having a wavelength adapted for absorption by blood chromophores, an excitation optical fiber and ...

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    15. Durable single mode fiber probe with optimized reference reflectivity

      Durable single mode fiber probe with optimized reference reflectivity

      A probe for a common path optical coherence tomography system includes a sheath having a proximal end and a distal end and defining a lumen therein, a single mode optical fiber disposed within the lumen of the sheath such that a portion of the single mode optical fiber extends beyond the distal end of the sheath. The single mode optical fiber has an end face for transmitting and receiving light. The probe also includes a layer of hardened epoxy encasing the portion of the single mode optical fiber that extends beyond the distal end of the sheath except for the ...

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    16. Flashlight-Sized Probe Can Spot Cancer Cells in Real Time

      Flashlight-Sized Probe Can Spot Cancer Cells in Real Time

      Malignant tumor strongholds and their microscopic spies can’t hide in the thicket of flesh much longer, for surgeons have a new weapon: a device that sheds light on their location. Literally. “Any state of disease will alter the cells and molecules in our body,” said Dr. Stephen Boppart, a professor of bioengineering at the University of Illinois who invented the device. Every molecule scatters light different ways, he said, “leaving a distinct optical scattering signature.” The new device senses cancer cells’ unique signatures, letting surgeons know which areas around the tumor are cancerous and which are safe to leave ...

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    17. Monitoring disposition of tethered capsule endoscope in esophagus

      Monitoring disposition of tethered capsule endoscope in esophagus

      A scanning flexible endoscope includes a tether attached to a capsule. The tether controls a disposition of the capsule within a body lumen such as the esophagus. A scanning device in the capsule optically scans the adjacent tissue on the inside surface of the body lumen as the capsule is moved axially through the body lumen. A non-contact sensor responds to indicia on the tether to measure a relative position of the tether and the capsule in the body lumen. The indicia can be analog or digital in form and the sensor can be either magnetic, or optical. A wiper ...

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    18. Expanding Functionality of Commercial Optical Coherence Tomography Systems by Integrating a Custom Endoscope

      Expanding Functionality of Commercial Optical Coherence Tomography Systems by Integrating a Custom Endoscope

      Optical coherence tomography (OCT) is a useful imaging modality for detecting and monitoring diseases of the gastrointestinal tract and other tubular structures. The non-destructiveness of OCT enables time-serial studies in animal models. While turnkey commercial research OCT systems are plenty, researchers often require custom imaging probes. We describe the integration of a custom endoscope with a commercial swept-source OCT system and generalize this description to any imaging probe and OCT system. A numerical dispersion compensation method is also described. Example images demonstrate that OCT can visualize the mouse colon crypt structure and detect adenoma in vivo .

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    19. Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery

      Real-time Imaging of the Resection Bed Using a Handheld Probe to Reduce Incidence of Microscopic Positive Margins in Cancer Surgery

      Wide local excision (WLE) is a common surgical intervention for solid tumors such as those in melanoma, breast, pancreatic, and gastrointestinal cancer. However, adequate margin assessment during WLE remains a significant challenge, resulting in surgical reinterventions to achieve adequate local control. Currently, no label-free imaging method is available for surgeons to examine the resection bed in vivo for microscopic residual cancer. Optical coherence tomography (OCT) enables real-time high-resolution imaging of tissue microstructure. Previous studies have demonstrated that OCT analysis of excised tissue specimens can distinguish between normal and cancerous tissues by identifying the heterogeneous and disorganized microscopic tissue structures indicative ...

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    20. Aberration corrected short working distance optical probe with large confocal parameter

      Aberration corrected short working distance optical probe with large confocal parameter

      An optical probe is provided. The optical probe includes a lens extending along an axis between a first end and a second end. A spacer extends along the axis between a first end and a second end. The first end of the spacer is connected to the second end of the lens. A prism is connected to the second end of the spacer such that the prism is spaced apart from the lens by the spacer.

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    21. High spatial resolution optical coherence tomography rotation catheter

      High spatial resolution optical coherence tomography rotation catheter

      An optical coherence tomography rotation catheter comprises a catheter body and a tubular member that rotates around a longitudinal axis in the catheter body. An optical fiber extends along an interior of the tubular member and has an optical fiber distal end. A light reflecting member is distal of the optical fiber distal end and rotates around the longitudinal axis with the tubular member. The light reflecting member includes a light reflecting surface which is spaced from and faces the optical fiber distal end and which is inclined to reflect the light from the optical fiber in a radial direction ...

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      Mentions: St. Jude Medical
    22. Optical probe and optical measuring method

      Optical probe and optical measuring method

      An optical measurement method that can suppress variation in detection sensitivity even if an optical probe is bent, and an optical probe suitably used for the method are provided. An optical probe 10 includes an optical fiber 11 that transmits light between a proximal end 11a and a distal end 11b, an optical connector 12 connected with the optical fiber 11 at a side of the proximal end 11a, a focusing optical system 13 and a deflecting optical system 14 optically connected with the optical fiber 11 at a side of the distal end 11b, and a support tube 15 ...

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    23. Catheter-based off-axis optical coherence tomography imaging system

      Catheter-based off-axis optical coherence tomography imaging system

      Catheter-based Optical Coherence Tomography (OCT) systems utilizing an optical fiber that is positioned off-axis of the central longitudinal axis of the catheter have many advantage over catheter-based OCT systems, particularly those having centrally-positioned optical fibers or fibers that rotate independently of the elongate body of the catheter. An OCT system having an off-axis optical fiber for visualizing the inside of a body lumen may be rotated with the body of the elongate catheter, relative to a handle portion. The handle may include a fiber management pathway for the optical fiber that permits the off-axis optical fiber to rotate with the ...

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    24. Method and measuring device for gauging surfaces

      Method and measuring device for gauging surfaces

      In a method for gauging surfaces (7''), in which a frequency-modulated laser beam is generated, the laser beam is emitted onto the surface as measuring radiation (MS), the measuring radiation (MS) backscattered from the surface (7'') is received and the distance between a reference point and the surface (7'') is measured interferometrically, wherein the measuring radiation (MS) is emitted and received while the surface to be gauged is being scanned, and a measuring arm and a reference interferometer arm with a partially common beam path are used, deviations from the essentially perpendicular impingement of the measuring radiation (MS) on the ...

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      Mentions: Leica
    1-24 of 450 1 2 3 4 ... 17 18 19 »
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    1. (1 articles) University of Freiburg