1. Articles in category: Probes

    1-24 of 525 1 2 3 4 ... 20 21 22 »
    1. Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model

      Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model

      Incorrect needle placement during an epidural block causes medical complications such as dural puncture or spinal cord injury. We propose a system combining an optical coherence tomography imaging probe with an automatic identification algorithm to objectively identify the epidural needle-tip position and thus reduce complications during epidural needle insertion. Eight quantitative features were extracted from each two-dimensional optical coherence tomography image during insertion of the needle tip from the skin surface to the epidural space. 847 in vivo optical coherence tomography images were obtained from three anesthetized piglets. The area under the receiver operating characteristic curve was used to quantify ...

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    2. Multi-channel optical coherence tomography probe for use in a medical procedure

      Multi-channel optical coherence tomography probe for use in a medical procedure

      A multi-channel optical coherence tomography probe for use in a medical procedure is provided. The probe comprises: a plurality of first optical fibers optically connectable to an OCT light source; a plurality of second optical fibers different from the plurality of first optical fibers; a scanning device comprising: an actuator configured to rotationally move the plurality of second optical fibers between a first position and a second position, relative to the plurality of first optical fibers; and, a mirror configured to, as the plurality of second optical fibers is moving rotationally, convey light from exit faces of the plurality of ...

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    3. Forward scanning-optical probes, circular scan patterns, offset fibers

      Forward scanning-optical probes, circular scan patterns, offset fibers

      An optical light scanning probe is presented, the probe comprising a handle, shaped for grasping by a user; a cannula, protruding from a distal portion of the handle with an outer diameter smaller than 20 gauge; an optical fiber with a distal fiber-portion off a probe-axis, configured to receive a light from a light-source at a proximal fiber-portion, and to emit the received light at the distal fiber-portion; a fixed beam forming unit, disposed at a distal portion of the cannula, configured to receive the light from the distal fiber-portion, and to deflect the received light toward a target region ...

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    4. MICRO-MOLDED Anamorphic Reflector Lens For Image Guided THERAPEUTIC/DIAGNOSTIC Catheters

      MICRO-MOLDED Anamorphic Reflector Lens For Image Guided THERAPEUTIC/DIAGNOSTIC Catheters

      A catheter system for optical coherence tomography includes an elongate catheter body, an optical fiber in the elongate catheter body, and an anamorphic lens assembly coupled with a distal end of the optical fiber. The optical fiber and the lens assembly are together configured to provide a common path for optical radiation reflected from a target and from a reference interface between the distal end of the optical fiber and the lens assembly

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    5. Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography

      Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography

      A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy (EM) is presented. The two modalities are physically co‐registered in a common‐path configuration. The instrument is enabled by a dedicated planar lightwave circuit with a footprint of only 1.1 x 19.5 mm 2 that provides akinetic axial OCT scanning at speeds up to 24 kHz. Lateral scanning is implemented through a low‐voltage MEMS mirror packaged with the axial scanner in a hermetic butterfly module. The OCT system, with a volume of only 80 x 27 x 14 ...

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    6. Dual-beam manually actuated distortion-corrected imaging (DMDI): two dimensional scanning with a single-axis galvanometer

      Dual-beam manually actuated distortion-corrected imaging (DMDI): two dimensional scanning with a single-axis galvanometer

      We recently demonstrated a new two-dimensional imaging paradigm called dual-beam manually actuated distortion-corrected imaging (DMDI). This technique uses a single mechanical scanner and two spatially separated beams to determine relative sample velocity and simultaneously corrects image distortions due to manual actuation. DMDI was first demonstrated using a rotating dual-beam micromotor catheter. Here, we present a new implementation of DMDI using a single axis galvanometer to scan a pair of beams in approximately parallel lines onto a sample. Furthermore, we present a method for automated distortion correction based on frame co-registration between images acquired by the two beams. Distortion correction is ...

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    7. In-Vitro Detection of Small Isolated Cartilage Defects: Intravascular Ultrasound Vs. Optical Coherence Tomography

      In-Vitro Detection of Small Isolated Cartilage Defects: Intravascular Ultrasound Vs. Optical Coherence Tomography

      This experimental work focused on the sensor selection for the development of a needle-like instrument to treat small isolated cartilage defects with hydrogels. The aim was to identify the most accurate and sensitive imaging method to determine the location and size of defects compared to a gold standard (µCT). Only intravascular ultrasound imaging (IVUS) vs. optical coherent tomography (OCT) were looked at, as they fulfilled the criteria for integration in the needle design. An in-vitro study was conducted on six human cadaveric tali that were dissected and submerged in saline. To simulate the natural appearance of cartilage defects, three types ...

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    8. Gradient Index Lens Assembly-Based Imaging Apparatus, Systems and Methods

      Gradient Index Lens Assembly-Based Imaging Apparatus, Systems and Methods

      <p id="p-0001" num="0000">In part, the disclosure relates to a lens assembly. The lens assembly can be used to direct light for sensing and imaging. In one embodiment, the lens assembly is a component of an intravascular data collection probe such as an optical coherence tomography probe. The lens assembly can include an optical fiber having a first diameter and a gradient index lens that includes a rod having a length L. The rod can include a substantial planar end and a polished end.

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      Mentions: St. Jude Medical
    9. Innovative Endoscopies to Be Clinically Used in the Near Future

      Innovative Endoscopies to Be Clinically Used in the Near Future

      In contrast to traditional single-lens endoscopies, recently introduced full-spectrum endoscopy (FUSE) scopes include multiple lenses providing a much wider field of view. In many studies, FUSE was shown to be feasible, effective, and safe, and FUSE colonoscopy yielded higher polyp (PDR), adenoma (ADR), and diverticular (DDR) detection rates than did traditional colonoscopy, without therapeutic failure or complications. Moreover, using FUSE gastroscopy, the prevalence of duodenal peri-ampullary diverticula (DPAD) in the general population could be analyzed without using ERCP. In the future, the next generation of modified FUSE system is expected to be useful in direct peroral cholangioscopy and in simultaneous ...

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    10. Common-path Optical Coherence Tomography using Bessel Beam from Negative Axicon Optical Fiber Tip

      Common-path Optical Coherence Tomography using Bessel Beam from Negative Axicon Optical Fiber Tip

      In this work a deep-seated negative axicon fiber tip (DSNA-FT) generating Bessel-Gauss beam is proposed as an optical probe for common-path optical coherence tomography (CPOCT) imaging. The axicon at the optical fiber tip is fabricated by etching the tip of a selective optical fiber in hydrofluoric acid under the influence of capillary action. The non-diffracting type quasi Bessel beam from the DSNA-FT having a long depth of field, ~0.7 mm, is used for CPOCT imaging of different type of samples i.e. sticky tape, fish scale, and rice grain. The CPOCT with unique and simple optical fiber probe has ...

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    11. Imaging Apparatus With Balloon And Shaped Tip

      Imaging Apparatus With Balloon And Shaped Tip

      Exemplary imaging apparatuses are described. Various imaging apparatuses may implement optical coherence tomography (OCT) and/or optical frequency domain imaging (OFDI) gastrointestinal tissue imaging methods and technologies. Furthermore, the imaging apparatuses may include a rotatable imaging element to scan a bodily lumen, such as the esophagus. The imaging element may be housed within an inflatable balloon. Still further, the imaging apparatuses may include a shaped tip. The shaped tip may aid in guiding an imaging apparatus through the esophagus, or other bodily lumen.

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    12. Review: Optical Scanning Probe for Optical Coherence Tomography

      Review: Optical Scanning Probe for Optical Coherence Tomography

      Optical coherence tomography (OCT) has become an important medical imaging modality. However, low penetration depth limits its application. Therefore, the optical scanning probe plays an important role in OCT systems for clinical applications. This article reviews OCT methodology and the mechanisms of an optical scanning probe. Recent developments of OCT probe and related clinical applications are summerized. Various OCT probe techniques (e.g., side imaging and forward imaging) have been used for measuring optical biopsy of various tissues. OCT probes for early diagnosis applications should be developed and combined with functional OCT modalities, such as Doppler OCT and polarization-sensitive OCT ...

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    13. Multimodality endoscopic optical coherence tomography and fluorescence imaging technology for visualization of layered architecture and subsurface microvasculature

      Multimodality endoscopic optical coherence tomography and fluorescence imaging technology for visualization of layered architecture and subsurface microvasculature

      Endoscopic imaging technologies, such as endoscopic optical coherence tomography (OCT) and near-infrared fluorescence, have been used to investigate vascular and morphological changes as hallmarks of early cancer in the gastrointestinal tract. Here we developed a high-speed multimodality endoscopic OCT and fluorescence imaging system. Using this system, the architectural morphology and vasculature of the rectum wall were obtained simultaneously from a Sprague Dawley rat in vivo . This multimodality imaging strategy in a single imaging system permits the use of a single imaging probe, thereby improving prognosis by early detection and reducing costs.

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    14. A System for Clinical Use of Endoscopic Optical Coherence Tomography

      A System for Clinical Use of Endoscopic Optical Coherence Tomography

      Introduction: Optical Coherence Tomography (OCT) allows non-invasive high-resolution imaging of tissues. With a penetration depth of a few millimeters it's possible to image the tympanic membrane and the close-by part of the tympanum, e.g. for diagnostics of otitis media and middle ear effusion. In the field of in vivo examination there are difficulties in access to the human tympanic membrane due to the narrow and curved external ear canal. We report a compact endoscopic OCT system for use in clinical research. Methods: We use a 3,5 mm endoscopic GRIN lens for video endoscopy and OCT. OCT is ...

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    15. Feature of The Week 04/27/2018: Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue

      Feature of The Week 04/27/2018: Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue

      The ability to visualize structure while simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double-clad fiber, including a thin layer of rare-earth-doped tellurite glass to enable temperature measurements. The high refractive index of the tellurite glass enables a common-path interferometer configuration for OCT, allowing easy exchange of probes for biomedical applications. The simultaneous imaging+sensing capability ...

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    16. Passively Driven Probe Based on Miniaturized Propeller for Intravascular Optical Coherence Tomography

      Passively Driven Probe Based on Miniaturized Propeller for Intravascular Optical Coherence Tomography

      Optical coherent tomography (OCT) has enabled clinical applications ranging from ophthalmology to cardiology that revolutionized in vivo medical diagnostics in the last few decades, and a variety of endoscopic probes have been developed in order to meet the needs of various endoscopic OCT imaging. We propose a passive driven intravascular optical coherent tomography (IV-OCT) probe in this paper. Instead of using any electrically driven scanning device, the probe makes use of the kinetic energy of the fluid that flushes away the blood during the intravascular optical coherence tomography imaging. The probe converts it into the rotational kinetic energy of the ...

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    17. Circumferential-scanning endoscopic optical coherence tomography probe based on a circular array of six 2-axis MEMS mirrors

      Circumferential-scanning endoscopic optical coherence tomography probe based on a circular array of six 2-axis MEMS mirrors

      We present a novel circumferential-scan endoscopic optical coherence tomography (OCT) probe by using a circular array of six electrothermal microelectromechanical (MEMS) mirrors and six C-lenses. The MEMS mirrors have a 0.5 mm × 0.5 mm mirror plate and a chip size of 1.5 mm × 1.3 mm. Each MEMS mirror can scan up to 45° at a voltage of less than 12 V. Six of those mirrors have been successfully packaged to a probe head; full circumferential scans have been demonstrated. Furthermore, each scan unit is composed of a MEMS mirror and a C-lens and the six scan ...

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      Mentions: Huikai K. Xie
    18. Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue

      Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue

      The ability to visualize structure while simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging + sensing imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double-clad fiber, including a thin layer of rare-earth-doped tellurite glass to enable temperature measurements. The high refractive index of the tellurite glass enables a common-path interferometer configuration for OCT, allowing easy exchange of probes for biomedical applications. The simultaneous imaging ...

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    19. Reduced back reflection optical coherence tomography probe

      Reduced back reflection optical coherence tomography probe

      A beam-shaping optical system suitable for use with optical coherence tomography including a sheath defining a central cavity, a beam-shaping insert defining a beam-shaping element positioned within the central cavity, and an optical fiber having a core and a cladding. The optical fiber defines an angularly prepared fiber end configured to emit an electromagnetic beam toward the beam-shaping element with the core of the optical fiber locally expanded at the fiber end.

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      Mentions: Corning
    20. A 2.8-mm-diameter scanhead for multispectral photoacoustic microscopy and optical coherence tomography

      A 2.8-mm-diameter scanhead for multispectral photoacoustic microscopy and optical coherence tomography

      An endoscopic probe with high resolution and multiple contrasts provides useful diagnostic information. For example, a miniature probe capable of multimodal imaging including photoacoustic imaging, optical coherence tomography (OCT), and ultrasound has been reported. However, microscale resolution is only realized in OCT modality in the probe, which may restrict the applications where high resolutions for multiple contrasts are required. Here, we present an approach to construct a miniature scanhead with 2.8 mm in diameter that achieves high-resolution multispectral photoacoustic microscopy (PAM) and OCT. The method realizes high resolution of ∼10 μm for both PAM and OCT. We experimentally demonstrate ...

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    21. Endoscopic optical coherence tomography with a flexible fiber bundle

      Endoscopic optical coherence tomography with a flexible fiber bundle

      We demonstrate in vivo endoscopic optical coherence tomography (OCT) imaging in the forward direction using a flexible fiber bundle. In comparison to current conventional forward looking probe schemes, our approach simplifies the endoscope design by avoiding the integration of any beam steering components in the distal probe end due to 2D scanning of a focused light beam over the proximal fiber bundle surface. We describe the challenges that arise when OCT imaging with a fiber bundle is performed, such as multimoding or cross-coupling. The performance of different fiber bundles with varying parameters such as numerical aperture, core size and core ...

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    22. Lights, camera, action! New endomicroscopic probes visualize living animal cell activity

      Lights, camera, action! New endomicroscopic probes visualize living animal cell activity

      Johns Hopkins researchers report they have developed two new endoscopic probes that significantly sharpen the technology’s imaging resolution and permit direct observation of fine tissue structures and cell activity in small organs in sheep, rats and mice. If clinical trials affirm the instruments’ value in humans, the researchers say, the scopes could one day reduce our dependence on invasive biopsies for diagnosing cancer and other diseases. “These tools are able to look into organs, such as the bile duct, pancreas and lungs, giving us a faster and safer way to diagnose a variety of diseases,” says Xingde Li, Ph ...

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    23. In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis

      In vivo broadband visible light optical coherence tomography probe enables inverse spectroscopic analysis

      We report the design and characterization of a 6 mm outer diameter pull-back circumferential scanning visible optical coherence tomography probe. The probe’s large visible bandwidth (500–695 nm) allowed for inverse spectroscopic analysis and an axial resolution of ∼ 1.1    μm ∼1.1  μm in tissue. We verify spectral imaging capabilities by measuring microsphere backscattering spectra and demonstrate in vivo spatial nanoscale characterization of tissue.

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    1-24 of 525 1 2 3 4 ... 20 21 22 »
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