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(11 articles) University of Florida
(7 articles) Massachusetts Institute of Technology
(7 articles) Johns Hopkins University
(5 articles) Gwangju Institute of Science and Technology
(5 articles) Harvard University
(4 articles) National University of Singapore
(4 articles) Massachusetts General Hospital
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Progress toward inexpensive endoscopic high-resolution common-path OCT
Explore Article SPIE Digital Library (Feb 24 2010) Endoscopy , Probes
Presented in this work is our effort to develop a simple, inexpensive high resolution fiber-optic Optical Coherence Tomography. The approach is based on common-path Fourier Domain OCT (CP-FDOCT), which can lead to applications for both microsurgical tool control and high-resolution endoscopic imaging. The system utilizes a combination of standard fiber optic components and novel signal processing techniques in order to achieve high axial resolution and to simplify the system. High axial resolution is achieved by implementing the Enhanced Lee filter to reduce speckle noise in the OCT image and Richardson-Lucy deconvolution algorithm afterwards to suppress sidelobes induced by the system's ...
Comment on Article Mentions: Jin U. Kang Johns Hopkins University
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Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) imaging system
Explore Article SPIE Digital Library (Feb 23 2010) Cardiology , Probes
Optical coherence tomography (OCT) and intravascular ultrasound (IVUS) are considered two complementary imaging techniques in the detection and diagnosis of atherosclerosis. OCT permits visualization of micron-scale features of atherosclerosis plaque, and IVUS offers full imaging depth of vessel wall. Under the guidance of IVUS, minimal amount of flushing agent will be needed to obtain OCT imaging of the interested area. We report on a dual-modality optical coherence tomography (OCT) - ultrasound (US) system for intravascular imaging. To the best of our knowledge, we have developed the first integrated OCT-US probe that combines OCT optical components with an ultrasound transducer. The ...
Comment on Article Mentions: UC Irvine Jun Zhang National Institutes of Health
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Perspectives of optical scanning in OCT
Explore Article SPIE Digital Library (Feb 23 2010) Probes
We present an overview of our contributions and directions of research in the domain of optical scanners, with regard to their perspectives of use in optical coherence tomography (OCT). The performances, advantages and drawbacks of the different types of scanning systems are summarized. Both 1-D and 2-D scanners for various applications in OCT, from swept source filters to flying the beam over the target are considered. We briefly present our developments of polygon mirror (PM) scanners. We study galvoscanners (GS) in order to increase their duty cycle in general and for high speed scanners in particular. The limitations in reaching ...
Comment on Article Mentions: Adrian G. Podoleanu University of Kent University of Rochester
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The OCT penlight: in-situ image guidance for microsurgery
Explore Article SPIE Digital Library (Feb 23 2010) Probes
, , et al. We have developed a new image-based guidance system for microsurgery using optical coherence tomography (OCT), which presents a virtual image in its correct location inside the scanned tissue. Applications include surgery of the cornea, skin, and other surfaces below which shallow targets may advant ... [Proc. SPIE 7625, 762502 (2010)] published Tue Feb 23, 2010.
Comment on Article Mentions: Larry Kagemann Gadi Wollstein Joel S. Schuman
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Optical micro-endoscopes for 3D in-vivo imaging
Explore Article Home: SPIE.org (Feb 22 2010) Endoscopy , Probes
Electrothermal micromirrors and a flexible printed circuit board permit fast, small optical coherence tomography of internal organs. Optical coherence tomography (OCT) is a medical optical imaging technique that can achieve high-resolution 3D images (1-15μm)1 by detecting infrared light scattered by body tissue. It has an imaging depth range of about 3mm in highly-scattered tissue and has already been widely used for external imaging, e.g., for eye diseases and skin cancer diagnosis. It would be useful to apply OCT to internal imaging, since about 85% of all cancers originate from the surface layers of internal organs. As these layers are within ...
Comment on Article Mentions: Lei Wu Huikai Xie University of Florida
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High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe
Explore Article opticsinfobase.org (Feb 17 2010) Endoscopy , Microscopy , Probes
ical coherence microscopy (OCM) is a promising technique for high resolution cellular imaging in human tissues. An OCM system for high-speed en face cellular resolution imaging was developed at 1060 nm wavelength at frame rates up to 5 Hz with resolutions of < 4 µm axial and < 2 µm transverse. The system utilized a novel polarization compensation method to combat wavelength dependent source polarization and achieve broadband electro-optic phase modulation compatible with ultrahigh axial resolution. In addition, the system incorporated an auto-focusing feature that enables precise, near real-time alignment of the confocal and coherence gates in tissue, allowing user-friendly ...
Comment on Article Mentions: James G. Fujimoto Shu-Wei Huang Aaron D. Aguirre
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In vivo 3D and Doppler OCT imaging using electrothermal MEMS scanning mirrors
Explore Article SPIE Digital Library (Feb 16 2010) Endoscopy , Oncology , Probes
Most cancers occur inside human body, so endoscopic high-resolution imaging modalities are required for early cancer detection and surgical removal. This paper reports in vivo endoscopic 3D imaging based on optical coherence tomography (OCT). Endoscopic imaging is enabled by integrating rapid-scanning MEMS mirror into a miniature imaging probe. The MEMS mirror has an aperture size of 1 mm by 1 mm and a chip size of 2 mm by 2 mm. The optical scan angle exceeds ±25 V at 6 Vdc, and thus large, constant-velocity, linear scan can be realized. The outer diameter of the probe is only 5 mm. ...
Comment on Article Mentions: Lei Wu Huikai Xie Shuguang Guo
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Investigation of gold-coated bare fiber probe for in situ intra-vitreous coherence domain optical imaging and sensing
Explore Article SpringerLink Home (Feb 9 2010) Ophthalmology , Probes
Abstract We have investigated the usage of gold-plated bare fiber probes for in situ imaging of retinal layers and surrounding ocular tissues using time-domain common-path optical coherence tomography. The fabricated intra-vitreous gold-plated micro-fiber probe can be fully integrated with surgical tools working in close proximity to the tissue to provide subsurface images having a self-contained reference plane independent to the Fresnel reflection between the distal end of the probe and the following medium for achieving reference in typical common-path optical coherence tomography. We have fully characterized the probe in an aqueous medium equivalent to the vitreous humor in the eye and ...
Comment on Article Mentions: Johns Hopkins University Food and Drug Administration Jin U. Kang
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Miniature actuator mechanism for intravascular imaging
Explore Article PatFT » Page 1 of 1 (Feb 9 2010) Cardiology , Patents , Probes
The present invention relates to a new intravascular imaging device based on a Shape Memory Alloy (SMA) actuator mechanism embedded inside an elongate member such as a guide wire or catheter. The present invention utilizes a novel SMA mechanism to provide side-looking imaging by providing movement for an ultrasound transducer element. This novel SMA actuator mechanism can be easily fabricated in micro-scale, providing an advantage over existing imaging devices because it offers the ability to miniaturize the overall size of the device, while the use of multiple transducer crystals maximizes field of view. Also disclosed are methods of using the ...
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Quantification of glycerol diffusion in human normal and cancer breast tissues in vitro with optical coherence tomography
Explore Article www3.interscience.wiley.com (Feb 8 2010) Oncology , Probes
Optical coherence tomography (OCT) holds great promise as a routine research tool for analysis of identifying the boundaries between normal and diseased breast tissue in vitro and in vivo. However, despite the depth penetration afforded by this imaging modality, light attenuation in tissues imposes limitations. Here we studied the optical clearing effect of glycerol in human cancer and normal breast tissues with OCT for functional imaging to monitor. Depth- and time-resolved profiles for OCT signal enhancement were presented. The results show that the OCT imaging depth and imaging contrast of breast tissues have been improved after application of 60% glycerol ...
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Manual-Scanning Optical Coherence Tomography (OCT) Probe Based on Position Tracking
Explore Article Optical Coherence Tomography News (Feb 6 2010) Probes
Feature Of The Week 2/7/10: Optical Coherence Tomography (OCT) is now an important modality in the field of biomedical imaging for its high resolution and non-invasive nature. People have been developing OCT endoscopes to penetrate into deep biological tissues and extend the limited light penetration depth in near infrared wavelength region. Different ways of steering the probing beam have been developed over the years. As most of them need some form of mechanical actuation, they usually come with the associated cost of additional hardware that must be integrated onto the probes. An OCT probe that can be manually swept over ...
Comment on Article Mentions: California Institute of Technology Changhuei Yang Jian Ren
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Ablation And Monitoring System Including A Fiber Optic Imaging Catheter And An Optical Coherence Tomography System (Wo 2010/011820)
Explore Article wipo.int (Jan 28 2010) Patents , Probes
An ablation and monitoring system comprises a catheter, an optical coherence tomography (OCT) system, and an ablation generator. The catheter comprises one or more optical fibers to transmit a light beam to a tissue material and collect a reflected light from the tissue material. The OCT system is in optical communication with the catheter via the one or more optical fibers, providing the light beam to the one or more optical fibers and receiving the reflected light from the one or more optical fibers. The ablation generator is in electrical communication with the OCT system and with the catheter. The ... -
High-resolution OCT explores the gut
Explore Article optics.org (Jan 25 2010) Endoscopy , Oncology , Probes
Fourier domain detection has greatly improved the speed and resolution of optical coherence tomography (OCT), opening up the possibility of in vivo clinical imaging. A team of Toronto-based researchers has now shown how this technology could be applied inside the gastrointestinal tract, a technique that could replace invasive biopsies when looking for early signs of cancer (Phys. Med. Biol. 55 615). The miniaturized OCT imager is the result of collaboration between the University of Toronto (Toronto, CA), Princess Margaret Hospital (Toronto, CA) and Michelson Diagnostics in the UK. The core technology is a multi-beam Fourier domain OCT system that uses ...
Comment on Article Mentions: Michelson Diagnostics Beau A. Standish University of Toronto
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Touching a nerve
Explore Article IEEE Xplore (Jan 20 2010) Probes
A new method to guide and control microsurgical tools using optical coherence tomography (OCT) is being developed by researchers at Johns Hopkins University and the US Food and Drug Administration Center for Devices and Radiological Health. In their recent work, which appears in this issue of Electronics Letters, the team have demonstrated a fi bre nerve stimulation probe integrated with an OCT distance sensor which can be controlled much more precisely; therefore signifi cantly improving the safety of the technique.
Comment on Article Mentions: Johns Hopkins University Food and Drug Administration Jin U. Kang
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Common-path optical coherence tomography guided fibre probe for spatially precise optical nerve stimulation
Explore Article IEEE Xplore (Jan 20 2010) Probes
A simple and effective common-path optical coherence tomography guided fibre probe for optical nerve stimulation has been developed and tested. The probe is capable of real-time monitoring of the fibre-to-nerve distance up to more than 1 mm at an axial resolution of approximately 3 μm, thus improving the precision and safety of stimulation laser power delivery.
Comment on Article Mentions: Johns Hopkins University Jin U. Kang
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