1. Articles in category: Probes

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    1. Research Associate / Research Fellow Microscope In A Needle at the University of Western Australia

      Research Associate / Research Fellow Microscope In A Needle at the University of Western Australia

      The SCHOOL OF ELECTRICAL, ELECTRONIC & COMPUTER ENGINEERING OPTICAL+BIOMEDICAL ENGINEERING LABORATORY 2 year appointment Salary range: Level A $63,332 - $85,942 p.a. or Level B $90,468 - $107,431 p.a. (dependent on qualifications and experience) Research & Development In Biomedical Photonics (Australia) The University of Western Australia (UWA) is a member of Australia's prestigious Group of Eight and ranked among the top 100 universities (88th in the world) with a broad and balanced coverage of disciplines in the arts, sciences and major professions. Could you build, maintain or deploy a state-of-the-art medical imaging instrument? Come join a ...

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    2. Real-time automated thickness measurement of the in vivo human tympanic membrane using optical coherence tomography

      Real-time automated thickness measurement of the in vivo human tympanic membrane using optical coherence tomography

      Background: Otitis media (OM), an infection in the middle ear, is extremely common in the pediatric population. Current gold-standard methods for diagnosis include otoscopy for visualizing the surface features of the tympanic membrane (TM) and making qualitative assessments to determine middle ear content. OM typically presents as an acute infection, but can progress to chronic OM, and after numerous infections and antibiotic treatments over the course of many months, this disease is often treated by surgically inserting small tubes in the TM to relieve pressure, enable drainage, and provide aeration to the middle ear. Diagnosis and monitoring of OM is ...

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    3. In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe

      In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe

      We report multimodal imaging of human oral cavity in vivo based on simultaneous wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography (PS-OCT) with a forward-viewing imaging probe. Wide-field reflectance/fluorescence imaging and PS-OCT were to provide both morphological and fluorescence information on the surface, and structural and birefringent information below the surface respectively. The forward-viewing probe was designed to access the oral cavity through the mouth with dimensions of approximately 10 mm in diameter and 180 mm in length. The probe had field of view (FOV) of approximately 5.5 mm in diameter, and adjustable depth of field (DOF ...

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    4. Injection-depth-locking axial motion guided handheld micro-injector using CP-SSOCT

      Injection-depth-locking axial motion guided handheld micro-injector using CP-SSOCT

      This paper presents a handheld micro-injector system using common-path swept source optical coherence tomography (CP-SSOCT) as a distal sensor with highly accurate injection-depth-locking. To achieve real-time, highly precise, and intuitive freehand control, the system used graphics processing unit (GPU) to process the oversampled OCT signal with high throughput and a smart customized motion monitoring control algorithm. A performance evaluation was conducted with 60-insertions and fluorescein dye injection tests to show how accurately the system can guide the needle and lock to the target depth. The evaluation tests show our system can guide the injection needle into the desired depth with ...

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    5. Johns Hopkins University Receives NIH Grant for OCT-Guided Free-Hand Semi-Automated Microsurgical Tool for Enhanced Retinal Surgery.

      Johns Hopkins University Receives NIH Grant for OCT-Guided Free-Hand Semi-Automated Microsurgical Tool for Enhanced Retinal Surgery.

      Johns Hopkins University Receives a 2014 NIH Grant for $91,945 for OCT-Guided Free-Hand Semi-Automated Microsurgical Tool for Enhanced Retinal Surgery. The principal investigator is Jin U. Kang. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Contemporary retinal microsurgery is performed by skilled surgeons through operating microscopes, utilizing free hand techniques and manually operated precision micro-instruments. We have assembled an interdisciplinary team including a clinician scientist and vitreoretinal surgeon, an optical device scientist and a systems integrator to translate existing and developing technology in our laboratories into practical application. To this ...

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    6. MEMS scanning micromirror for optical coherence tomography

      MEMS scanning micromirror for optical coherence tomography

      This paper describes an endoscopic-inspired imaging system employing a micro-electromechanical system (MEMS) micromirror scanner to achieve beam scanning for optical coherence tomography (OCT) imaging. Miniaturization of a scanning mirror using MEMS technology can allow a fully functional imaging probe to be contained in a package sufficiently small for utilization in a working channel of a standard gastroesophageal endoscope. This work employs advanced image processing techniques to enhance the images acquired using the MEMS scanner to correct non-idealities in mirror performance. The experimental results demonstrate the effectiveness of the proposed technique.

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    7. Chemical Strategies for the Development of Multimodal Imaging Probes Using Nanoparticles (Book Chapter)

      Chemical Strategies for the Development of Multimodal Imaging Probes Using Nanoparticles (Book Chapter)

      This chapter focuses on the most recently reported nanoparticle agents that have been demonstrated in vivo . It describes the general methods of chemical conjugations, silanisation, and electrostatic adsorption. The chapter examines the recent use of nanoparticles that incorporate a fluorescent dye and a magnetic nanoparticle together. The combination of near-infrared (NIR) and magnetic resonance imaging (MRI) modalities and in vivo characterisation has been executed in two ways: attaching an organic NIR dye to a superparamagnetic iron oxide nanoparticle (SPION); and combining SPIONs with a materials-based NIR fluorescent species such as a quantum dot or multilayered gold/silica nanoparticles. Upconversion luminescence ...

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    8. Fiber-needle Swept-source Optical Coherence Tomography System for the Identification of the Epidural Space in Piglets

      Fiber-needle Swept-source Optical Coherence Tomography System for the Identification of the Epidural Space in Piglets

      Background: Epidural needle insertion is traditionally a blind technique whose success depends on the experience of the operator. The authors describe a novel method using a fiber-needle-based swept-source optical coherence tomography (SSOCT) to identify epidural space. Methods: An optical fiber probe was placed into a hollow 18-gauge Tuohy needle. It was then inserted by an experienced anesthesiologist to continuously construct a series of two-dimensional SSOCT images by mechanically rotating the optical probe. To quantify this observation, both the average SSOCT signal intensities and their diagnostic potentials were assessed. The insertions were performed three times into both the lumbar and thoracic ...

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      Mentions: Wen-Chuan Kuo
    9. MEMS-Based Handheld Fourier Domain Doppler Optical Coherence Tomography for Intraoperative Microvascular Anastomosis Imaging

      MEMS-Based Handheld Fourier Domain Doppler Optical Coherence Tomography for Intraoperative Microvascular Anastomosis Imaging

      Purpose To demonstrate the feasibility of a miniature handheld optical coherence tomography (OCT) imager for real time intraoperative vascular patency evaluation in the setting of super-microsurgical vessel anastomosis. Methods A novel handheld imager Fourier domain Doppler optical coherence tomography based on a 1.3-µm central wavelength swept source for extravascular imaging was developed. The imager was minimized through the adoption of a 2.4-mm diameter microelectromechanical systems (MEMS) scanning mirror, additionally a 12.7-mm diameter lens system was designed and combined with the MEMS mirror to achieve a small form factor that optimize functionality as a handheld extravascular OCT ...

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    10. Hand scanning optical coherence tomography imaging using encoder feedback

      Hand scanning optical coherence tomography imaging using encoder feedback

      We present a new method for generating micron-scale OCT images of interstitial tissue with a hand scanning probe and a linear optical encoder that senses probe movement relative to a fixed reference point, i.e., tissue surface. Based on this approach, we demonstrate high resolution optical imaging of biological tissues through a very long biopsy needle. Minor artifacts caused by tissue noncompliance are corrected using a software algorithm which detects the simple repetition of the adjacent A-scans. This hand-scanning OCT imaging approach offers the physician the freedom to access imaging sites of interest repeatedly.

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    11. Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging

      Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging

      In this Letter, we present a trimodality imaging system and an intravascular endoscopic probe for the detection of early-stage atherosclerotic plaques. The integrated system is able to acquire optical coherence tomography (OCT), fluorescence, and ultrasound images and simultaneously display them in real time. A trimodality intravascular endoscopic probe of 1.2 mm in diameter and 7 mm in length was fabricated based on a dual-modality optical probe that integrates OCT and fluorescence imaging functions and a miniature ultrasound transducer. The probe is capable of rotating at up to 600 rpm. Ex vivo images from rabbit aorta and human coronary arteries ...

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    12. Low coherence interferometry approach for aiding fine needle aspiration biopsie

      Low coherence interferometry approach for aiding fine needle aspiration biopsie

      We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation. Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.

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    13. Characterization and micro-assembly of electrostatic actuators for 3-DOF micromanipulators in laser phonomicrosurgery

      Characterization and micro-assembly of electrostatic actuators for 3-DOF micromanipulators in laser phonomicrosurgery

      This paper presents a design of electrostatic actuators for 3-DOF micromanipulators in robot-assisted laser phonomicrosurgery. By integrating three sets of electrostatic actuators in a vertical configuration, scanning micro-mirror can be used as a manipulator for laser source. Key enable technology for these miniaturized actuators is microfabrication processes for microelectromechanical systems (MEMS) because the processes can create submicron features with high precision, mass productive, and low cost. Based on precise micromachined electrostatic actuators, the platform is assembled using micro assembly approach. With sizes less than 5 mm × 5 mm × 5 mm, the proposed design has three degree-of-freedom: two rotational motions around ...

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    14. OCT Vitrectomy Probe

      OCT Vitrectomy Probe

      Disclosed herein is a vitrectomy probe, comprising a beam steering system configured to receive a light beam from a sample fiber of an optical coherence tomography instrument; a fundus illumination system configured to receive a beam of white light from a white light source via a multimode fiber; a dichroic mirror; and a beam delivery system configured to illuminate the retina of a subject.

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    15. Fabrication method of ultra-small gradient-index fiber probe

      Fabrication method of ultra-small gradient-index fiber probe

      Fabrication method and device of ultra-small gradient-index (GRIN) fiber probe were investigated in order to explore the development of ultra-small probes for optical coherence tomography (OCT) imaging. The beam-expanding effect of no-core fiber (NCF) and the focusing properties of the GRIN fiber lens were analyzed based on the model of GRIN fiber probe consisting of single-mode fiber (SMF), NCF and GRIN fiber lens. A stereo microscope based system was developed to fabricate the GRIN fiber probe. A fiber fusion splicer and an ultrasonic cleaver were used to weld and cut the fiber respectively. A confocal microscopy was used to measure ...

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    16. Feature Of The Week 10/5/14: Design and Testing of Handheld Scanning Probe Prototypes for Optical Coherence Tomography

      Feature Of The Week 10/5/14: Design and Testing of Handheld Scanning Probe Prototypes for Optical Coherence Tomography

      Three simple and low-cost configurations of handheld scanning probes for optical coherence tomography have been developed. Their design and testing for dentistry applications are presented. The first two configurations were built exclusively from available off-the-shelf optomechanical components, which, to the best of our knowledge, are the first designs of this type. The third configuration includes these components in an optimized and ergonomic probe. All the designs are presented in detail to allow for their duplication in any laboratory with a minimum effort, for applications that range from educational to high-end clinical investigations. Requirements that have to be fulfilled to achieve ...

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    17. University of Maryland Receives NIH Grant for Monitoring Photo-Immunotherapy Using Multi-Channel Multi-Modal Imaging Needles

      University of Maryland Receives NIH Grant for Monitoring Photo-Immunotherapy Using Multi-Channel Multi-Modal Imaging Needles

      University of Maryland Receives a 2014 NIH Grant for $76,000 for Monitoring Photo-Immunotherapy Using Multi-Channel Multi-Modal Imaging Needles. The principal investigator is Yu Chen. The program began in 2014 and ends in 2016. Below is a summary of the proposed work. Photo-immunotherapy (PIT) is an emerging low-side-effect cancer therapy based on monoclonal antibody (mAb) conjugated with a near-infrared (NIR) phthalocyanine dye (IR700) that induces rapid cellular necrosis after exposure to near infrared light. Although single administration of the therapy (agent + light) was highly effective, recurrences were observed due to the inhomogeneous mAb-IR700 distribution in the tumor. Repeated therapy has ...

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    18. Preliminary Design and Evaluation of a B-Scan OCT-Guided Needle

      Preliminary Design and Evaluation of a B-Scan OCT-Guided Needle

      Real-time intraoperative B-scan optical coherence tomography (OCT) visualization of intraocular tissues is a desired ophthalmic feature during retinal procedures. A novel intraocular 25-gauge B-mode forward-imaging OCT probe was combined with a 36-gauge needle into a prototype instrument. Imaging of the needle tip itself and the effects of saline injection into a gelatin phantom were performed. A combined B-scan forward-imaging OCT-needle prototype was capable of real-time-imaging of saline injection into a gelatin phantom. Additional future miniaturization may permit this instrument to be an adjunctive real-time imaging and procedure tool for vitreoretinal surgery.

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    19. Insert Imaging Device For Surgical Procedures

      Insert Imaging Device For Surgical Procedures

      Insertable imaging devices, and methods of use thereof in minimally invasive medical procedures, are described. In some embodiments, insertable imaging devices are described that can be introduced and removed from an access port without disturbing or risking damage to internal tissue. In some embodiments, imaging devices are integrated into an access port, thereby allowing imaging of internal tissues within the vicinity of the access port, while, for example, enabling manipulation of surgical tools in the surgical field of interest. In other embodiments, imaging devices are integrated into an imaging sleeve that is insertable into an access port. Several example embodiments ...

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    20. Optical Fiber Beam Directing Systems And Apparatuses

      Optical Fiber Beam Directing Systems And Apparatuses

      In one aspect, the invention relates to a lens (52) configured for optical coherence tomography imaging. The lens includes a substantially cylindrical body (52) having a longitudinal axis and includes a first end, an outer cylindrical surface, and a beam directing surface at a second end, the substantially cylindrical body and the outer cylindrical surface defining a trench (58) in between the first end and the beam directing surface, the beam directing surface being oriented at an angle to the longitudinal axis, and the trench being sized to accept an optical fiber. In another aspect, the invention relates to a ...

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      Mentions: St. Jude Medical
    21. True color scanning laser ophthalmoscopy and optical coherence tomography handheld probe

      True color scanning laser ophthalmoscopy and optical coherence tomography handheld probe

      Scanning laser ophthalmoscopes (SLOs) are able to achieve superior contrast and axial sectioning capability compared to fundus photography. However, SLOs typically use monochromatic illumination and are thus unable to extract color information of the retina. Previous color SLO imaging techniques utilized multiple lasers or narrow band sources for illumination, which allowed for multiple color but not “true color” imaging as done in fundus photography. We describe the first “true color” SLO, handheld color SLO, and combined color SLO integrated with a spectral domain optical coherence tomography (OCT) system. To achieve accurate color imaging, the SLO was calibrated with a color ...

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    1-24 of 396 1 2 3 4 ... 15 16 17 »
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