1. Articles in category: Probes

    1-24 of 384 1 2 3 4 ... 14 15 16 »
    1. Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging

      Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging

      In this Letter, we present a trimodality imaging system and an intravascular endoscopic probe for the detection of early-stage atherosclerotic plaques. The integrated system is able to acquire optical coherence tomography (OCT), fluorescence, and ultrasound images and simultaneously display them in real time. A trimodality intravascular endoscopic probe of 1.2 mm in diameter and 7 mm in length was fabricated based on a dual-modality optical probe that integrates OCT and fluorescence imaging functions and a miniature ultrasound transducer. The probe is capable of rotating at up to 600 rpm. Ex vivo images from rabbit aorta and human coronary arteries ...

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    2. Low coherence interferometry approach for aiding fine needle aspiration biopsie

      Low coherence interferometry approach for aiding fine needle aspiration biopsie

      We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation. Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.

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    3. Characterization and micro-assembly of electrostatic actuators for 3-DOF micromanipulators in laser phonomicrosurgery

      Characterization and micro-assembly of electrostatic actuators for 3-DOF micromanipulators in laser phonomicrosurgery

      This paper presents a design of electrostatic actuators for 3-DOF micromanipulators in robot-assisted laser phonomicrosurgery. By integrating three sets of electrostatic actuators in a vertical configuration, scanning micro-mirror can be used as a manipulator for laser source. Key enable technology for these miniaturized actuators is microfabrication processes for microelectromechanical systems (MEMS) because the processes can create submicron features with high precision, mass productive, and low cost. Based on precise micromachined electrostatic actuators, the platform is assembled using micro assembly approach. With sizes less than 5 mm × 5 mm × 5 mm, the proposed design has three degree-of-freedom: two rotational motions around ...

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    4. OCT Vitrectomy Probe

      OCT Vitrectomy Probe

      Disclosed herein is a vitrectomy probe, comprising a beam steering system configured to receive a light beam from a sample fiber of an optical coherence tomography instrument; a fundus illumination system configured to receive a beam of white light from a white light source via a multimode fiber; a dichroic mirror; and a beam delivery system configured to illuminate the retina of a subject.

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    5. Fabrication method of ultra-small gradient-index fiber probe

      Fabrication method of ultra-small gradient-index fiber probe

      Fabrication method and device of ultra-small gradient-index (GRIN) fiber probe were investigated in order to explore the development of ultra-small probes for optical coherence tomography (OCT) imaging. The beam-expanding effect of no-core fiber (NCF) and the focusing properties of the GRIN fiber lens were analyzed based on the model of GRIN fiber probe consisting of single-mode fiber (SMF), NCF and GRIN fiber lens. A stereo microscope based system was developed to fabricate the GRIN fiber probe. A fiber fusion splicer and an ultrasonic cleaver were used to weld and cut the fiber respectively. A confocal microscopy was used to measure ...

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    6. Feature Of The Week 10/5/14: Design and Testing of Handheld Scanning Probe Prototypes for Optical Coherence Tomography

      Feature Of The Week 10/5/14: Design and Testing of Handheld Scanning Probe Prototypes for Optical Coherence Tomography

      Three simple and low-cost configurations of handheld scanning probes for optical coherence tomography have been developed. Their design and testing for dentistry applications are presented. The first two configurations were built exclusively from available off-the-shelf optomechanical components, which, to the best of our knowledge, are the first designs of this type. The third configuration includes these components in an optimized and ergonomic probe. All the designs are presented in detail to allow for their duplication in any laboratory with a minimum effort, for applications that range from educational to high-end clinical investigations. Requirements that have to be fulfilled to achieve ...

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    7. University of Maryland Receives NIH Grant for Monitoring Photo-Immunotherapy Using Multi-Channel Multi-Modal Imaging Needles

      University of Maryland Receives NIH Grant for Monitoring Photo-Immunotherapy Using Multi-Channel Multi-Modal Imaging Needles

      University of Maryland Receives a 2014 NIH Grant for $76,000 for Monitoring Photo-Immunotherapy Using Multi-Channel Multi-Modal Imaging Needles. The principal investigator is Yu Chen. The program began in 2014 and ends in 2016. Below is a summary of the proposed work. Photo-immunotherapy (PIT) is an emerging low-side-effect cancer therapy based on monoclonal antibody (mAb) conjugated with a near-infrared (NIR) phthalocyanine dye (IR700) that induces rapid cellular necrosis after exposure to near infrared light. Although single administration of the therapy (agent + light) was highly effective, recurrences were observed due to the inhomogeneous mAb-IR700 distribution in the tumor. Repeated therapy has ...

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    8. Preliminary Design and Evaluation of a B-Scan OCT-Guided Needle

      Preliminary Design and Evaluation of a B-Scan OCT-Guided Needle

      Real-time intraoperative B-scan optical coherence tomography (OCT) visualization of intraocular tissues is a desired ophthalmic feature during retinal procedures. A novel intraocular 25-gauge B-mode forward-imaging OCT probe was combined with a 36-gauge needle into a prototype instrument. Imaging of the needle tip itself and the effects of saline injection into a gelatin phantom were performed. A combined B-scan forward-imaging OCT-needle prototype was capable of real-time-imaging of saline injection into a gelatin phantom. Additional future miniaturization may permit this instrument to be an adjunctive real-time imaging and procedure tool for vitreoretinal surgery.

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    9. Optical Fiber Beam Directing Systems And Apparatuses

      Optical Fiber Beam Directing Systems And Apparatuses

      In one aspect, the invention relates to a lens (52) configured for optical coherence tomography imaging. The lens includes a substantially cylindrical body (52) having a longitudinal axis and includes a first end, an outer cylindrical surface, and a beam directing surface at a second end, the substantially cylindrical body and the outer cylindrical surface defining a trench (58) in between the first end and the beam directing surface, the beam directing surface being oriented at an angle to the longitudinal axis, and the trench being sized to accept an optical fiber. In another aspect, the invention relates to a ...

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      Mentions: St. Jude Medical
    10. Insert Imaging Device For Surgical Procedures

      Insert Imaging Device For Surgical Procedures

      Insertable imaging devices, and methods of use thereof in minimally invasive medical procedures, are described. In some embodiments, insertable imaging devices are described that can be introduced and removed from an access port without disturbing or risking damage to internal tissue. In some embodiments, imaging devices are integrated into an access port, thereby allowing imaging of internal tissues within the vicinity of the access port, while, for example, enabling manipulation of surgical tools in the surgical field of interest. In other embodiments, imaging devices are integrated into an imaging sleeve that is insertable into an access port. Several example embodiments ...

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    11. True color scanning laser ophthalmoscopy and optical coherence tomography handheld probe

      True color scanning laser ophthalmoscopy and optical coherence tomography handheld probe

      Scanning laser ophthalmoscopes (SLOs) are able to achieve superior contrast and axial sectioning capability compared to fundus photography. However, SLOs typically use monochromatic illumination and are thus unable to extract color information of the retina. Previous color SLO imaging techniques utilized multiple lasers or narrow band sources for illumination, which allowed for multiple color but not “true color” imaging as done in fundus photography. We describe the first “true color” SLO, handheld color SLO, and combined color SLO integrated with a spectral domain optical coherence tomography (OCT) system. To achieve accurate color imaging, the SLO was calibrated with a color ...

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    12. Parallel guidance endoscopic optical coherence tomography system for internal diagnosis through active cannulas

      Parallel guidance endoscopic optical coherence tomography system for internal diagnosis through active cannulas

      A parallel guidance endoscopic optical coherence tomography (OCT) system is proposed for minimally invasive internal inspection of inner organs or complex structures for diagnosis. The system is maneuvered to access the target using an active cannulas’ steerable structures. The integration of a specially designed linkage device with the developed system allows the OCT endoscope to scan with enhanced signal-collective performance, while maintaining its tip at a constant distance from the target, as well as expanding the scanning range. The proposed system is integrated with flexible active cannulas, and this prototype is used for testing. The test results show that the ...

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    13. Imaging probe with combined ultrasound and optical means of imaging

      Imaging probe with combined ultrasound and optical means of imaging

      The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and optical coherence tomography. The imaging probes structures using high resolution imaging use combined high frequency ultrasound (IVUS) and optical imaging methods such as optical coherence tomography (OCT) and to accurate co-registering of images obtained from ultrasound image signals and optical image, signals during scanning a region of interest.

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    14. In vivo imaging of functional microvasculature within tissue beds of oral and nasal cavities by swept-source optical coherence tomography with a forward/side-viewing probe

      In vivo imaging of functional microvasculature within tissue beds of oral and nasal cavities by swept-source optical coherence tomography with a forward/side-viewing probe

      We report three-dimensional (3D) imaging of microcirculation within human cavity tissues in vivo using a high-speed swept-source optical coherence tomography (SS-OCT) at 1300 nm with a modified probe interface. Volumetric structural OCT images of the inner tissues of oral and nasal cavities are acquired with a field of view of 2 mm × 2 mm. Two types of disposable and detachable probe attachments are devised and applied to the port of the imaging probe of OCT system, enabling forward and side imaging scans for selective and easy access to specific cavity tissue sites. Blood perfusion is mapped with OCT-based microangiography from ...

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    15. Intravascular Optical Coherence Tomography System with Pressure Monitoring Interface and Accessories

      Intravascular Optical Coherence Tomography System with Pressure Monitoring Interface and Accessories

      An optical coherence tomography system and method with integrated pressure measurement. In one embodiment the system includes an interferometer including: a wavelength swept laser; a source arm in communication with the wavelength swept laser; a reference arm in communication with a reference reflector; a first photodetector having a signal output; a detector arm in communication with the first photodetector, a probe interface; a sample arm in communication with a first optical connector of the probe interface; an acquisition and display system comprising: an A/D converter having a signal input in communication with the first photodetector signal output and a ...

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    16. Ultrasound guided optical coherence tomography, photoacoustic probe for biomedical imaging

      Ultrasound guided optical coherence tomography, photoacoustic probe for biomedical imaging

      An imaging probe for a biological sample includes an OCT probe and an ultrasound probe combined with the OCT probe in an integral probe package capable of providing by a single scanning operation images from the OCT probe and ultrasound probe to simultaneously provide integrated optical coherence tomography (OCT) and ultrasound imaging of the same biological sample. A method to provide high resolution imaging of biomedical tissue includes the steps of finding an area of interest using the guidance of ultrasound imaging, and obtaining an OCT image and once the area of interest is identified where the combination of the ...

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    17. Handheld imaging probe

      Handheld imaging probe

      A handheld imaging probe for performing optical coherence tomography is disclosed. The handheld imaging probe includes a lens tube and a housing. The lens tube contains an objective lens and a polycarbonate sheet. The polycarbonate sheet provides a bio-safe contact with a tissue sample to be examined. The housing, which is connected to the lens tube, contains a micromirror for directing a laser beam to irradiate the tissue sample via the objective lens and the polycarbonate sheet.

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    18. Forward viewing OCT endomicroscopy (Thesis)

      Forward viewing OCT endomicroscopy (Thesis)

      A forward viewing fiber optic-based imaging probe device was designed and constructed for use with ultrahigh speed optical coherence tomography in the human gastrointestinal tract. The light source was a MEMS-VCSEL at 1300 nm wavelength running at 300 kHz sweep rate, giving an effective A-line rate of 600 kHz. Data was acquired with a 1.8 GS/s A/D card optically clocked by a maximum fringe frequency of 1 GHz. The optical beam from the probe was scanned by a freely deflecting optical fiber that was mounted proximally on a piezoelectric tubular actuator, which was electrically driven in two ...

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    19. Durable Single Mode Fiber Probe With Optimized Reference Reflectivity

      Durable Single Mode Fiber Probe With Optimized Reference Reflectivity

      A probe for a common path optical coherence tomography system includes a sheath having a proximal end and a distal end and defining a lumen therein, a single mode optical fiber disposed within the lumen of the sheath such that a portion of the single mode optical fiber extends beyond the distal end of the sheath. The single mode optical fiber has an end face for transmitting and receiving light. The probe also includes a layer of hardened epoxy encasing the portion of the single mode optical fiber that extends beyond the distal end of the sheath except for the ...

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    20. Sapphire LENS-BASED Optical Fiber Probe For Optical Coherence Tomography

      Sapphire LENS-BASED Optical Fiber Probe For Optical Coherence Tomography

      A probe for an optical coherence tomography system according to an embodiment of the current invention includes a sheath having a proximal end and a distal end and defining a lumen therein, an optical fiber disposed at least partially within the lumen of said sheath, and a sapphire lens attached to the distal end of the sheath to form a fluid-tight seal to prevent fluid from entering the lumen of said sheath. The optical fiber has an end arranged in an optical path with the sapphire lens to provide optical coupling between the sapphire lens and the optical fiber.

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    21. Fiber-optic polarization diversity detection for rotary probe optical coherence tomography

      Fiber-optic polarization diversity detection for rotary probe optical coherence tomography

      We report a polarization diversity detection scheme for optical coherence tomography with a new, custom, miniaturized fiber coupler with single mode (SM) fiber inputs and polarization maintaining (PM) fiber outputs. The SM fiber inputs obviate matching the optical lengths of the X and Y OCT polarization channels prior to interference and the PM fiber outputs ensure defined X and Y axes after interference. Advantages for this scheme include easier alignment, lower cost, and easier miniaturization compared to designs with free-space bulk optical components. We demonstrate the utility of the detection system to mitigate the effects of rapidly changing polarization states ...

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    22. Method and apparatus for providing high-fill-factor micromirror/micromirror arrays with surface mounting capability

      Method and apparatus for providing high-fill-factor micromirror/micromirror arrays with surface mounting capability

      Embodiments of the subject invention relate to micromirror devices and methods of fabricating a micromirror/micromirror array. According to an embodiment, micromirrors can be fabricated from a semiconductor substrate where after forming actuators and bonding pads on a front side of the semiconductor substrate, the device is flipped over to have a portion of the back side of the substrate removed and formed to become the mirror plate surface. The subject micromirrors can allow further miniaturization of endoscopes and other optical applications without sacrificing the optical aperture through their surface mounting capabilities.

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      Mentions: Huikai K. Xie
    23. Optofluidic needle probe integrating targeted delivery of fluid with optical coherence tomography imaging

      Optofluidic needle probe integrating targeted delivery of fluid with optical coherence tomography imaging

      We present an optofluidic optical coherence tomography (OCT) needle probe capable of modifying the local optical properties of tissue to improve needle-probe imaging performance. The side-viewing probe comprises an all-fiber-optic design encased in a hypodermic needle (outer diameter 720 μm) and integrates a coaxial fluid-filled channel, terminated by an outlet adjacent to the imaging window, allowing focal injection of fluid to a target tissue. This is the first fully integrated OCT needle probe design to incorporate fluid injection into the imaging mechanism. The utility of this probe is demonstrated in air-filled sheep lungs, where injection of small quantities of saline ...

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    1-24 of 384 1 2 3 4 ... 14 15 16 »
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  2. Popular Articles

  3. Organizations in the News

    1. (1 articles) Center for Ophthalmic Optics and Lasers
    2. (1 articles) Harvard University
    3. (1 articles) Oregon Health & Science University
    4. (1 articles) Massachusetts General Hospital
    5. (1 articles) FEMTO-ST Institute
    6. (1 articles) University of Southern California
  4. People in the News

    1. (1 articles) Guillermo J. Tearney
    2. (1 articles) Xiang Li
    3. (1 articles) Zhongping Chen
    4. (1 articles) Jiawen Li
    5. (1 articles) Yimin Wang
    6. (1 articles) Jun Zhang
    7. (1 articles) Ernest W. Chang
    8. (1 articles) Qifa Zhou
    9. (1 articles) K. Kirk Shung
    10. (1 articles) David Huang
    11. (1 articles) Nicusor Iftimia
  5. OCT Companies in the News

    1. (1 articles) Physical Sciences Incorporated
    2. (1 articles) NinePoint Medical