1. Articles in category: Probes

    1-24 of 545 1 2 3 4 ... 21 22 23 »
    1. An ultraslim all-fiber microendoscope for depth-resolved imaging

      An ultraslim all-fiber microendoscope for depth-resolved imaging

      We demonstrate an ultraslim all-fiber microendoscope for depth-resolved imaging that integrates a gradient-index (GRIN) fiber and an imaging fiber bundle. The desired imaging depth is achieved through a high-precision adjustment of the length of the GRIN fiber. A fusion splicing of this fiber to an imaging fiber bundle, with provisions for a carefully tailored adiabatic conical transition region, keeps these fiber components robustly aligned, enabling a high-quality image transmission with no compromise on fiber-probe flexibility. With the maximum outer diameter of this microendoscope scalable down to ≈50  μ m, the range of envisaged applications spans from depth-resolved brain imaging, deep optical ...

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    2. Integrated optical coherence tomography and multielement ultrasound transducer probe for shear wave elasticity imaging of moving tissues

      Integrated optical coherence tomography and multielement ultrasound transducer probe for shear wave elasticity imaging of moving tissues

      Accurate measurements of microelastic properties of soft tissues in-vivo using optical coherence elastography can be affected by motion artifacts caused by cardiac and respiratory cycles. This problem can be overcome using a multielement ultrasound transducer probe where each ultrasound transducer is capable of generating acoustic radiation force (ARF) and, therefore, creating shear waves in tissue. These shear waves, produced during the phase of cardiac and respiratory cycles when tissues are effectively stationary, are detected at the same observation point using phase-sensitive optical coherence tomography (psOCT). Given the known distance between the ultrasound transducers, the speed of shear wave propagation can ...

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    3. Advanced imaging technology for arteries and veins developed by UK engineers

      Advanced imaging technology for arteries and veins developed by UK engineers

      Engineers at Cambridge Consultants have developed a 1.35mm diameter, 0.16 megapixels prototype HD camera called Leap, a cheap, single-use endoscope that can be operated from a standard computer. Leap can give an accurate image of the inside of arteries and veins, and is flexible and sufficiently small enough to use during an intracoronary angioscopy for example. Leap allows surgeons to undertake tissue classification or direct imaging of non-standard vascular occlusions, and could be used in conjunction with intravascular ultrasounds and optical coherence tomography for superior diagnostic techniques during surgery. Simon Karger, head of Surgical and Interventional Products at ...

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    4. Forward and side imaging optical coherence tomography probe

      Forward and side imaging optical coherence tomography probe

      A forward-imaging optical coherence tomography probe is provided, comprising: a substantially cylindrical housing comprising: a longitudinal axis; an interior side; a distal end that is optically transparent; and a mirror located at the interior side, adjacent the distal end; an optical fiber located inside the cylindrical housing along the longitudinal axis; a wedge lens located inside the cylindrical housing, adjacent the distal end, the wedge lens configured to receive light from the fiber, and direct the light towards the mirror; and, at least one motor configured to both: rotate the fiber and the wedge lens about the longitudinal axis and ...

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    5. Radiofrequency ablation catheter with optical tissue evaluation

      Radiofrequency ablation catheter with optical tissue evaluation

      Systems and methods for performing RF ablation while monitoring the procedure using low coherence interferometry (LCI) data are described. A catheter includes a distal section, a proximal section, a multiplexer, and a sheath coupled between the distal section and the proximal section. The distal section includes several interconnected optical ports configured to transmit exposure radiation toward a sample and receive radiation that have been reflected or scattered from the sample. The interconnected optical ports are formed on a substrate having rigid sections and flexible sections arranged around the distal section. A holder maintains the interconnected optical elements in a fixed ...

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    6. Optic axis mapping with catheter-based polarization-sensitive optical coherence tomography

      Optic axis mapping with catheter-based polarization-sensitive optical coherence tomography

      Birefringence offers an intrinsic contrast mechanism related to the microstructure and arrangement of fibrillary tissue components. Here we present a reconstruction strategy to recover not only the scalar amount of birefringence, but also its optic axis orientation as a function of depth in tissue from measurements with catheter-based polarization-sensitive optical coherence tomography. A polarization symmetry constraint, intrinsic to imaging in the backscatter direction, facilitates the required compensation for wavelength-dependent transmission through the system elements, the rotating catheter, and overlying tissue layers. Applied to the intravascular imaging of coronary atherosclerosis in human patients, the optic axis affords refined interpretation of plaque ...

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    7. Super‐achromatic Optical Coherence Tomography Capsule for Ultrahigh‐resolution Imaging of Esophagus

      Super‐achromatic Optical Coherence Tomography Capsule for Ultrahigh‐resolution Imaging of Esophagus

      Endoscopic optical coherence tomography (OCT) is a noninvasive technology allowing for imaging of tissue microanatomies of luminal organs in real time. Conventional endoscopic OCT operates at 1,300 nm wavelength region with a sub‐optimal axial resolution limited to 8‐20 μm. In this paper we present the first ultrahigh‐resolution tethered OCT capsule operating at 800 nm and offering about 3‐4 fold improvement of axial resolution (plus enhanced imaging contrast). The capsule uses diffractive optics to manage chromatic aberration over a full ~200 nm spectral bandwidth centering around 830 nm, enabling to achieve super‐achromaticity and an axial ...

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    8. A miniature endoscopic optical coherence tomography probe based on C-lens

      A miniature endoscopic optical coherence tomography probe based on C-lens

      We present a novel miniature endoscopic OCT probe based on an electrothermal microelectromechanical (MEMS) mirror and a C-lens. The MEMS mirror has a relatively large mirror plate of 0.5 mm×0.5 mm on a small chip size of 1.5 mm×1.3 mm, leading to the outer diameter of the endoscopic probe down to only 2.5 mm so that the probe is capable of being inserted through the biopsy channel of a conventional endoscope. A long focal length of 12 mm is achieved by properly designing the C-lens. Compared to commonly used GRIN lenses, C-lenses have ...

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    9. Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes

      Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes

      Miniaturised optical coherence tomography (OCT) fibre-optic probes have enabled high-resolution cross-sectional imaging deep within the body. However, existing OCT fibre-optic probe fabrication methods cannot generate miniaturised freeform optics, which limits our ability to fabricate probes with both complex optical function and dimensions comparable to the optical fibre diameter. Recently, major advances in two-photon direct laser writing have enabled 3D printing of arbitrary three-dimensional micro/nanostructures with a surface roughness acceptable for optical applications. Here, we demonstrate the feasibility of 3D printing of OCT probes. We evaluate the capability of this method based on a series of characterisation experiments. We report ...

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    10. Swept-source optical coherence tomography microsystem with an integrated Mirau interferometer and electrothermal micro-scanner

      Swept-source optical coherence tomography microsystem with an integrated Mirau interferometer and electrothermal micro-scanner

      In the rapid evolution of gastrointestinal endomicroscopy, optical coherence tomography (OCT) has found many diverse applications. Until recently, the micro-opto–electro-mechanical systems (MOEMS) technology has been playing a key role in shaping the miniaturization of these components. We report here, to the best of our knowledge, a novel endoscopic microsystem. It is based on a spectrally tuned MOEMS Mirau micro-interferometer integrated with micro-electro-mechanical systems (MEMS) electro-thermal micro-scanner, operating in the regime of swept-source (SS) OCT imaging. This Letter validates our initial proof-of-concept toward the development of such MOEMS probe and the presentation of experimental performances of the resulting SS-OCT microsystem. .

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    11. High-accuracy endoscopic microscopy using a thin, 1.5 mm diameter probe with optical coherence tomography

      High-accuracy endoscopic microscopy using a thin, 1.5 mm diameter probe with optical coherence tomography

      We developed an endoscopic microscopy system with 20 nm accuracy that affords inspection through narrow gaps using a thin, 1.5 mm diameter probe. Accuracy was improved using Optical Coherence Tomography (OCT). The frequency modulated light source is stabilized with closed control from self-interference measurement. The probe is driven by two miniature motors, which allow three-dimensional scanning of an internal surface. Imaging performance is 60 frames per second. The high accuracy with narrow clearance capabilities of this system reduces the need for machine overhauls, which affords trustworthy daily inspections and hence greater machine reliability.

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    12. Processing-based approach for resolving the sample optic axis in endoscopic polarization-sensitive optical coherence tomography

      Processing-based approach for resolving the sample optic axis in endoscopic polarization-sensitive optical coherence tomography

      Fiber-based polarization-sensitive optical coherence tomography (PS-OCT) that utilizes a rotationally-scanning catheter has a variety of potential biomedical applications in luminal organ systems due to its ability to provide intrinsic contrast for birefringent tissue. Incorporating the optic axis (OA) of the tissue greatly enhances this potential by also permitting information about the orientation of the tissue to be extracted; however, measurement distortion that occurs has up to this point made it impossible to obtain accurate sample OA measurements. In this paper we present a straightforward calibration technique that allows the sample OA to be recovered. This technique requires no hardware modifications ...

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    13. High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography

      High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography

      We present a forward-viewing fiber scanning endoscope (FSE) for high-speed volumetric optical coherence tomography (OCT). The reduction in size of the probe was achieved by substituting the focusing optics by an all-fiber-based imaging system which consists of a combination of scanning single-mode fibers, a glass spacer, made from a step-index multi-mode fiber, and a gradient-index fiber. A lateral resolution of 11 μm was achieved at a working distance of 1.2 mm. The newly designed piezo-based FSE has an outer diameter of 1.6 mm and a rigid length of 13.5 mm. By moving the whole imaging optic in ...

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    14. Surgical instrument and systems with integrated optical sensor

      Surgical instrument and systems with integrated optical sensor

      A surgical instrument has a surgical tool that has a proximal end and a distal end, and an optical sensor that has at least a portion attached to the surgical tool. The surgical tool has a portion that is suitable to provide a reference portion of the surgical tool, and the optical sensor has an end fixed relative to the reference portion of the surgical tool such that the reference portion of the surgical tool can be detected along with tissue that is proximate or in contact with the distal end of the surgical tool while in use.

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    15. Guarded imaging devices and methods

      Guarded imaging devices and methods

      An integrated therapeutic and imaging device that uses at least two balloons to provide a guarded zone that can be evacuated and replaced with a fluid that is sufficiently clear to permit optical coherence tomography (or even high resolution ultrasound) imaging that would otherwise be of poor quality or impossible. Methods of making and operating the imaging device to obtain clear, high quality images, as well as treating a patient's tissue with the device within a living body in association with obtaining an image of the patient's tissue, are included.

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    16. Optical probe and optical coherence tomography apparatus including the same

      Optical probe and optical coherence tomography apparatus including the same

      An optical probe for irradiating light onto a subject includes an optical path control unit configured to receive light from outside the optical probe, and change a path of the light within the optical probe; an optical path length control element configured to receive the light having the changed path from the optical path control unit, and change an optical path length of the light as the optical path control unit changes the path of the light; and an optical output unit configured to receive the light having the changed optical path length from the optical path length control element ...

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      Mentions: Samsung
    17. Adalimumab Microneedles in Healthy Volunteers

      Adalimumab Microneedles in Healthy Volunteers

      Adalimumab (Humira, AbbVie) is a highly effective treatment for a variety of auto-immune/auto-inflammatory diseases including juvenile idiopathic arthritis (JIA). Adalimumab works by binding to tumor necrosis factor alpha (TNF), hereby preventing its interaction with the TNF receptor. In the presence of complement, adalimumab can also lyse TNF-expressing cells. Adalimumab is administered via subcutaneous injection, which has the major drawback of being perceived as unpleasant and painful, especially during long term use for both adults and children. As subcutaneous administration may therefore eventually jeopardize treatment adherence, there is a clear need for less invasive alternatives to administer highly effective biological ...

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    18. Nano-optic endoscope for high-resolution optical coherence tomography in vivo

      Nano-optic endoscope for high-resolution optical coherence tomography in vivo

      Acquisition of high-resolution images from within internal organs using endoscopic optical imaging has numerous clinical applications. However, difficulties associated with optical aberrations and the trade-off between transverse resolution and depth of focus significantly limit the scope of applications. Here, we integrate a metalens, with the ability to modify the phase of incident light at subwavelength level, into the design of an endoscopic optical coherence tomography catheter (termed nano-optic endoscope) to achieve near diffraction-limited imaging through negating non-chromatic aberrations. Remarkably, the tailored chromatic dispersion of the metalens in the context of spectral interferometry is utilized to maintain high-resolution imaging beyond the ...

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    19. All-optical dual photoacoustic and optical coherence tomography intravascular probe

      All-optical dual photoacoustic and optical coherence tomography intravascular probe

      Intravascular imaging in percutaneous coronary interventions can be an invaluable tool in the treatment of coronary artery disease. It is of significant interest to provide molecular imaging contrast that is complementary to structural contrast provided by optical coherence tomography (OCT) and intravascular ultrasound imaging (IVUS). In this study, we developed a dual-modality intravascular imaging probe comprising a commercial OCT catheter and a high sensitivity fiber optic ultrasound sensor, to provide both photoacoustic (PA) and OCT imaging. With PA imaging, the lateral resolution varied from 18 µm to 40 µm; the axial resolution was consistently in the vicinity of 45 µm ...

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    20. Friction torque limiter for an imaging catheter

      Friction torque limiter for an imaging catheter

      The invention provides a frictional torque limiter assembly for an imaging core spinning in a patient's body. The torque limiter assembly torsionally isolates the imaging core from a motor that spins the imaging core. An interference fit between a slitted drive tube and a spacer tube acts as a clutch that allows a spinning imaging probe to slow or stop relative to the motor until the motor is stopped, thereby preventing an unsafe condition.

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      Mentions: St. Jude Medical
    21. Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model

      Intelligent epidural needle placement using fiber-probe optical coherence tomography in a piglet model

      Incorrect needle placement during an epidural block causes medical complications such as dural puncture or spinal cord injury. We propose a system combining an optical coherence tomography imaging probe with an automatic identification algorithm to objectively identify the epidural needle-tip position and thus reduce complications during epidural needle insertion. Eight quantitative features were extracted from each two-dimensional optical coherence tomography image during insertion of the needle tip from the skin surface to the epidural space. 847 in vivo optical coherence tomography images were obtained from three anesthetized piglets. The area under the receiver operating characteristic curve was used to quantify ...

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    22. Multi-channel optical coherence tomography probe for use in a medical procedure

      Multi-channel optical coherence tomography probe for use in a medical procedure

      A multi-channel optical coherence tomography probe for use in a medical procedure is provided. The probe comprises: a plurality of first optical fibers optically connectable to an OCT light source; a plurality of second optical fibers different from the plurality of first optical fibers; a scanning device comprising: an actuator configured to rotationally move the plurality of second optical fibers between a first position and a second position, relative to the plurality of first optical fibers; and, a mirror configured to, as the plurality of second optical fibers is moving rotationally, convey light from exit faces of the plurality of ...

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    23. Forward scanning-optical probes, circular scan patterns, offset fibers

      Forward scanning-optical probes, circular scan patterns, offset fibers

      An optical light scanning probe is presented, the probe comprising a handle, shaped for grasping by a user; a cannula, protruding from a distal portion of the handle with an outer diameter smaller than 20 gauge; an optical fiber with a distal fiber-portion off a probe-axis, configured to receive a light from a light-source at a proximal fiber-portion, and to emit the received light at the distal fiber-portion; a fixed beam forming unit, disposed at a distal portion of the cannula, configured to receive the light from the distal fiber-portion, and to deflect the received light toward a target region ...

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    24. MICRO-MOLDED Anamorphic Reflector Lens For Image Guided THERAPEUTIC/DIAGNOSTIC Catheters

      MICRO-MOLDED Anamorphic Reflector Lens For Image Guided THERAPEUTIC/DIAGNOSTIC Catheters

      A catheter system for optical coherence tomography includes an elongate catheter body, an optical fiber in the elongate catheter body, and an anamorphic lens assembly coupled with a distal end of the optical fiber. The optical fiber and the lens assembly are together configured to provide a common path for optical radiation reflected from a target and from a reference interface between the distal end of the optical fiber and the lens assembly

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    1-24 of 545 1 2 3 4 ... 21 22 23 »
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