1. Articles in category: Probes

    1-24 of 674 1 2 3 4 ... 26 27 28 »
    1. Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia

      Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia

      We report the design and fabrication of a flexible, longitudinally scanning high-resolution micro-optical coherence tomography (μOCT) endobronchial probe, optimized for micro-anatomical imaging in airways. The 2.4 mm diameter and flexibility of the probe allows it to be inserted into the instrument channel of a standard bronchoscope, enabling real-time video guidance of probe placement. To generate a depth-of-focus enhancing annular beam, we utilized a new fabrication method, whereby a hollow glass ferrule was angle-polished and gold-coated to produce an elongated annular reflector. We present validation data that verifies the preservation of linear scanning, despite the use of flexible materials. When ...

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    2. Passively scanned, single-fiber optical coherence tomography probes for gastrointestinal devices

      Passively scanned, single-fiber optical coherence tomography probes for gastrointestinal devices

      Background/objectives: Optical coherence tomography (OCT) uses low coherence interferometry to obtain depth-resolved tissue reflectivity profiles (M-mode) and transverse beam scanning to create images of two-dimensional tissue morphology (B-mode). Endoscopic OCT imaging probes typically employ proximal or distal mechanical beam scanning mechanisms that increase cost, complexity, and size. Here, we demonstrate in the gastrointestinal (GI) tracts of unsedated human patients, that a passive, single-fiber probe can be used to guide device placement, conduct device-tissue physical contact sensing, and obtain two-dimensional OCT images via M-to-B-mode conversion. Materials and methods: We designed and developed ultrasmall, manually scannable, side- and forward-viewing single fiber-optic ...

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    3. Ex-vivo evaluation of miniaturized probes for endoscopic optical coherence tomography in urothelial cancer diagnostics

      Ex-vivo evaluation of miniaturized probes for endoscopic optical coherence tomography in urothelial cancer diagnostics

      Background: The gold standard for detecting bladder cancer is white light cystoscopy (WLC) and resection of suspicious lesions. In this study, we evaluate two miniaturized Optical Coherence Tomography (OCT) probes for endoscopic use, regarding their applicability in diagnosing urothelial cancer. Materials and methods: In total, 33 patients who underwent a radical cystectomy were included. Preoperative oncological staging and determining the indication for the surgical intervention were done following the latest European Association of Urology (EAU) guidelines. Samples were taken from bladder tissue after bladder removal and prepared for OCT measurement. Additionally, porcine bladder samples were used as reference tissue. We ...

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    4. Epidural anesthesia needle guidance by forward-view endoscopic optical coherence tomography and deep learning

      Epidural anesthesia needle guidance by forward-view endoscopic optical coherence tomography and deep learning

      Epidural anesthesia requires injection of anesthetic into the epidural space in the spine. Accurate placement of the epidural needle is a major challenge. To address this, we developed a forward-view endoscopic optical coherence tomography (OCT) system for real-time imaging of the tissue in front of the needle tip during the puncture. We tested this OCT system in porcine backbones and developed a set of deep learning models to automatically process the imaging data for needle localization. A series of binary classification models were developed to recognize the five layers of the backbone, including fat, interspinous ligament, ligamentum flavum, epidural space ...

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    5. Methods, devices, and support structures for assembling optical fibers in catheter tips

      Methods, devices, and support structures for assembling optical fibers in catheter tips

      Described herein are methods, devices, and support structures for assembling optical fibers in catheter tips and facilitating alignment and structural support. A method for assembling a plurality of optical fibers and lenses in a support structure for an ablation catheter includes providing a support structure with a proximal end, a body, and a distal end, wherein the distal end includes a plurality of alignment orifices or slits.

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      Mentions: MedLumics
    6. Imaging probe with rotatable core

      Imaging probe with rotatable core

      The present disclosure provides for an imaging probe with a rotatable core which allows for rotating imaging assembly that is larger in diameter than the lumen in which the rotatable core resides, as well as methods to construct said probes. The imaging probes are generally elongate flexible imaging catheters for use in cardiovascular procedures.

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    7. Apparatus, device and method for capsule microscopy

      Apparatus, device and method for capsule microscopy

      An exemplary apparatus for obtaining data for at least one portion within at least one luminal or hollow sample can be provided. For example, the apparatus can include a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the portion(s). The apparatus can also include a wavelength dispersive second arrangement, which can be configured to disperse the electromagnetic radiation(s). A housing can be provided with a shape of a pill, and enclosing the first and second arrangements.

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    8. In vivo PS-OCT needle probe scan of human skeletal muscle

      In vivo PS-OCT needle probe scan of human skeletal muscle

      Polarization-sensitive optical coherence tomography (PS-OCT) derived birefringence values effectively identify skeletal muscle structural disruption due to muscular dystrophy and exercise-related muscle damage in animal models in ex vivo tissue. The purpose of this investigation was to determine if a PS-OCT needle probe inserted into the leg of a human subject could accurately identify various anatomical structures with implications for use as a diagnostic tool for the determination of skeletal muscle pathology. A healthy middle-aged subject participated in this study. A custom-built PS-OCT system was interfaced with a side-viewing fiber-optic needle probe inserted into the subject’s vastus lateralis muscle via ...

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    9. Esophageal optical coherence tomography image synthesis using an adversarially learned variational autoencoder

      Esophageal optical coherence tomography image synthesis using an adversarially learned variational autoencoder

      Endoscopic optical coherence tomography (OCT) imaging offers a non-invasive way to detect esophageal lesions on the microscopic scale, which is of clinical potential in the early diagnosis and treatment of esophageal cancers. Recent studies focused on applying deep learning-based methods in esophageal OCT image analysis and achieved promising results, which require a large data size. However, traditional data augmentation techniques generate samples that are highly correlated and sometimes far from reality, which may not lead to a satisfied trained model. In this paper, we proposed an adversarial learned variational autoencoder (AL-VAE) to generate high-quality esophageal OCT samples. The AL-VAE combines ...

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    10. Dual-mode endoscope offers unprecedented insights into uterine health

      Dual-mode endoscope offers unprecedented insights into uterine health

      Researchers have developed a new endoscope that combines ultrasound with optical coherence tomography (OCT) to assess structural features of the lining of the uterus, called the endometrium, in unprecedented detail. The new probe could one day help doctors diagnose infertility problems that are related to endometrial receptivity with greater accuracy than current imaging technologies while reducing the need for invasive biopsies.

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    11. Integrated US-OCT-NIRF Tri-modality Endoscopic Imaging System for Pancreaticobiliary Duct Imaging

      Integrated US-OCT-NIRF Tri-modality Endoscopic Imaging System for Pancreaticobiliary Duct Imaging

      Pancreaticobiliary carcinomas is a highly malignant gastrointestinal tumor. Most pancreaticobiliary cancers arise from epithelial proliferations within the pancreaticobiliary ducts, referred to as pancreatic intraepithelial neoplasias (PanINs). Some PanINs are benign metaplasia, while others progress to invasive duct adenocarcinoma (IDAC). However, there is no standard programme to diagnose the progression from PanINs to IDAC. In this study, we present a tri-modality imaging system, which integrates ultrasound (US), optical coherence tomography (OCT), and near-infrared fluorescence (NIRF) for pancreaticobiliary duct imaging. This system can obtain OCT, US, and NIRF images in real time with a frame rate of 30 frames per second. For ...

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    12. Ultrathin lensed fiber based anastigmatic needle probe for endoscopic swept source optical coherence tomography

      Ultrathin lensed fiber based anastigmatic needle probe for endoscopic swept source optical coherence tomography

      We present an anastigmatic all-fiber needle probe utilizing a fiber ball lens for endoscopic swept source optical coherence tomography (OCT). In order to avoid the astigmatism caused by the cylindrical profile of the imaging fiber or the outer protective tube, the lensed fiber probe is directly packaged into a 26-gauge hypodermic needle with a side opening optical window. A total internal reflection surface is fabricated on the tip of the no-core fiber (NCF) to deflect the beam with the lowest power loss. The working distance and the focused spot size of the probe can be optimized by adjusting the length ...

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    13. Pencil-beam scanning catheter for intracoronary optical coherence tomography

      Pencil-beam scanning catheter for intracoronary optical coherence tomography

      Current gradient-index (GRIN) lens based proximal-driven intracoronary optical coherence tomography (ICOCT) probes consist of a spacer and a GRIN lens with large gradient constant. This design provides great flexibility to control beam profiles, but the spacer length should be well controlled to obtain desired beam profiles and thus it sets an obstacle in mass catheter fabrication. Besides, although GRIN lens with large gradient constant can provide tight focus spot, it has short depth of focus and fast-expanded beam which leads to poor lateral resolution for deep tissue. In this paper, a type of spacer-removed probe is demonstrated with a small ...

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    14. Analysis and reduction of noise-induced depolarization in catheter based polarization sensitive optical coherence tomography

      Analysis and reduction of noise-induced depolarization in catheter based polarization sensitive optical coherence tomography

      In catheter based polarization sensitive optical coherence tomography (PS-OCT), a optical fiber with a rapid rotation in the catheter can cause low signal-to-noise ratio (SNR), polarization state instability, phase change of PS-OCT signals and then heavy noise-induced depolarization, which has a strong impact on the phase retardation measurement of the sample. In this paper, we analyze the noise-induced depolarization and find that the effect of depolarization can be reduced by polar decomposition after incoherent averaging in the Mueller matrix averaging (MMA) method. Namely, MMA can reduce impact of noise on phase retardation mapping. We present a Monte Carlo method based ...

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    15. OCT imaging catheter with lag correction

      OCT imaging catheter with lag correction

      A catheter system includes a catheter body, an imaging sensor, a drive motor, a current sensor, a display, and a controller. The catheter body includes a drive shaft. The imaging sensor is fixed relative to the distal end of the driveshaft and is configured to rotate therewith. The drive motor is configured to rotate the drive shaft. The current sensor is configured to measure an amount of current drawn by the drive motor as the drive shaft is rotated.

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      Mentions: Avinger
    16. 3D-Printed Micro Lens-in-Lens for In Vivo Multimodal Microendoscopy

      3D-Printed Micro Lens-in-Lens for In Vivo Multimodal Microendoscopy

      Multimodal microendoscopes enable co-located structural and molecular measurements in vivo, thus providing useful insights into the pathological changes associated with disease. However, different optical imaging modalities often have conflicting optical requirements for optimal lens design. For example, a high numerical aperture (NA) lens is needed to realize high-sensitivity fluorescence measurements. In contrast, optical coherence tomography (OCT) demands a low NA to achieve a large depth of focus. These competing requirements present a significant challenge in the design and fabrication of miniaturized imaging probes that are capable of supporting high-quality multiple modalities simultaneously. An optical design is demonstrated which uses two-photon ...

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    17. Endoscopic OCT probes with immersed MEMS mirrors

      Endoscopic OCT probes with immersed MEMS mirrors

      Methods and apparatuses for enlarging the optical scan angle of imaging probes are provided. The optical scan angle of endoscopic probes can be increased by employing the "Snell's Window" effect. An endoscopic probe can include an endoscope shell, a device for capturing electromagnetic radiation, and a liquid or gel provided between the device for capturing electromagnetic radiation and the endoscope shell. The endoscope probe can further include a first mirror placed such that electromagnetic radiation entering through the endoscope shell can bounce off the first mirror and enter the device for capturing electromagnetic radiation. The first mirror can be ...

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    18. Fiber optic imaging probe having cladding mode pullback trigger, and control method therefor

      Fiber optic imaging probe having cladding mode pullback trigger, and control method therefor

      An optical coherence tomographic (OCT) system includes a sample arm, a reference arm and an OCT probe. The probe irradiates a bodily lumen and a fluid contained within the bodily lumen with light of a sample beam transmitted through a double-clad fiber (DCF). A first detector detects light of a reference beam and light reflected from the bodily lumen and propagated through the core of the DCF to generate OCT interference signals. Light backscattered by the bodily lumen and by the fluid contained in the bodily lumen is propagated through a cladding of the DCF and detected by a second ...

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    19. Double-Clad Fiber-Based Multifunctional Biosensors and Multimodal Bioimaging Systems: Technology and Applications

      Double-Clad Fiber-Based Multifunctional Biosensors and Multimodal Bioimaging Systems: Technology and Applications

      Optical fibers have been used to probe various tissue properties such as temperature, pH, absorption, and scattering. Combining different sensing and imaging modalities within a single fiber allows for increased sensitivity without compromising the compactness of an optical fiber probe. A double-clad fiber (DCF) can sustain concurrent propagation modes (single-mode, through its core, and multimode, through an inner cladding), making DCFs ideally suited for multimodal approaches. This study provides a technological review of how DCFs are used to combine multiple sensing functionalities and imaging modalities. Specifically, we discuss the working principles of DCF-based sensors and relevant instrumentation as well as ...

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    20. Needle-Probe Optical Coherence Tomography for Real-Time Visualization of Veress Peritoneal Needle Placement in a Porcine Model: A New Safety Concept for Pneumoperitoneum Establishment in Laparoscopic Surgery

      Needle-Probe Optical Coherence Tomography for Real-Time Visualization of Veress Peritoneal Needle Placement in a Porcine Model: A New Safety Concept for Pneumoperitoneum Establishment in Laparoscopic Surgery

      The safe establishment of pneumoperitoneum is a critical step in all laparoscopic surgeries. A closed pneumoperitoneum is usually obtained by inserting a Veress needle into the peritoneal cavity. However, there is no definite measure to visually confirm the position of the Veress needle tip inside the peritoneal cavity. This study aimed to describe a method of real-time visual detection of peritoneal placement of the Veress needle using an incorporated optical coherence tomography (OCT) probe in a porcine model. A 14-gauge Veress needle was incorporated with a miniature fiber probe to puncture the piglet’s abdominal wall into the peritoneal cavity ...

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    21. Mirrorcle Technologies concludes successful SPIE Photonics West 2022

      Mirrorcle Technologies concludes successful SPIE Photonics West 2022

      The world leading manufacturer of MEMS-based optical beam-steering products and system solutions, Mirrorcle Technologies, announces the successful completion of the first live, in-person, Photonics West after the cancellation of the 2021 show. Finally, SPIE was held again at the Moscone Center in San Francisco, attracting more than 3200 technical attendees and almost 3000 exhibition visitors from around the world. Mirrorcle’ presence, in addition to exhibiting its products on the show floor, included the presentation of an academic paper on recent developments surrounding the company’s patented gimbal-less MEMS mirrors and how they will enable robotics solutions, as well as the ...

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    22. Endoscopic en-face optical coherence tomography and fluorescence imaging using correlation-based probe tracking

      Endoscopic en-face optical coherence tomography and fluorescence imaging using correlation-based probe tracking

      Forward-viewing endoscopic optical coherence tomography (OCT) provides 3D imaging in vivo , and can be combined with widefield fluorescence imaging by use of a double-clad fiber. However, it is technically challenging to build a high-performance miniaturized 2D scanning system with a large field-of-view. In this paper we demonstrate how a 1D scanning probe, which produces cross-sectional OCT images (B-scans) and 1D fluorescence T-scans, can be transformed into a 2D scanning probe by manual scanning along the second axis. OCT volumes are assembled from the B-scans using speckle decorrelation measurements to estimate the out-of-plane motion along the manual scan direction. Motion within ...

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    23. Computer-aided Veress needle guidance using endoscopic optical coherence tomography and convolutional neural networks

      Computer-aided Veress needle guidance using endoscopic optical coherence tomography and convolutional neural networks

      During laparoscopic surgery, the Veress needle is commonly used in pneumoperitoneum establishment. Precise placement of the Veress needle is still a challenge for the surgeon. In this study, a computer-aided endoscopic optical coherence tomography (OCT) system was developed to effectively and safely guide Veress needle insertion. This endoscopic system was tested by imaging subcutaneous fat, muscle, abdominal space, and the small intestine from swine samples to simulate the surgical process, including the situation with small intestine injury. Each tissue layer was visualized in OCT images with unique features and subsequently used to develop a system for automatic localization of the ...

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    24. Esophageal OCT Imaging Using a Paddle Probe Externally Attached to Endoscope

      Esophageal OCT Imaging Using a Paddle Probe Externally Attached to Endoscope

      Background and aims: Endoscopic surveillance of Barrett's esophagus (BE) by white light examination is insufficient to diagnose dysplastic change. In this work, we describe an optical imaging method to obtain high-resolution cross-sectional imaging using a paddle-shaped probe affixed to the endoscope tip. Methods: We integrated Optical Coherence Tomography (OCT), an optical imaging method that produces cross-sectional images, into a paddle probe attached to video endoscope. We acquired images of esophageal epithelium from patients undergoing routine upper GI endoscopy. Images were classified by a reviewer blinded to patient identity and condition, and these results were compared with clinical diagnosis. Results ...

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    1-24 of 674 1 2 3 4 ... 26 27 28 »
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    1. (2 articles) Massachusetts General Hospital
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