1. Articles in category: Probes

    1-24 of 404 1 2 3 4 ... 15 16 17 »
    1. In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

      In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

      Optical coherence tomography (OCT) is the optical equivalent of ultrasound imaging, based on the backscattering of near infrared light. OCT provides real time images with a 15 µm axial resolution at an effective tissue penetration of 2-3 mm. Within the OCT images the loss of signal intensity per millimeter of tissue penetration, the attenuation coefficient, is calculated. The attenuation coefficient is a tissue specific property, providing a quantitative parameter for tissue differentiation. Until now, renal mass treatment decisions have been made primarily on the basis of MRI and CT imaging characteristics, age and comorbidity. However these parameters and diagnostic methods ...

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    2. Laser tissue coagulation and concurrent optical coherence tomography through a double-clad fiber coupler

      Laser tissue coagulation and concurrent optical coherence tomography through a double-clad fiber coupler

      Double-clad fiber (DCF) is herein used in conjunction with a double-clad fiber coupler (DCFC) to enable simultaneous and co-registered optical coherence tomography (OCT) and laser tissue coagulation. The DCF allows a single channel fiber-optic probe to be shared: i.e. the core propagating the OCT signal while the inner cladding delivers the coagulation laser light. We herein present a novel DCFC designed and built to combine both signals within a DCF (>90% of single-mode transmission; >65% multimode coupling). Potential OCT imaging degradation mechanisms are also investigated and solutions to mitigate them are presented. The combined DCFC-based system was used to ...

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    3. Rotational MEMS mirror with latching arm for silicon photonics

      Rotational MEMS mirror with latching arm for silicon photonics

      We present an innovative rotational MEMS mirror that can control the direction of propagation of light beams inside of planar waveguides implemented in silicon photonics. Potential applications include but are not limited to optical telecommunications, medical imaging, scan and spectrometry. The mirror has a half-cylinder shape with a radius of 300 μm that provides low and constant optical losses over the full angular displacement range. A circular comb drive structure is anchored such that it allows free or latched rotation experimentally demonstrated over 8.5° (X-Y planar rotational movement) using 290V electrostatic actuation. The entire MEMS structure was implemented using ...

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    4. Optical Coherence Tomography Optical Fiber Assembly Capabilities

      Optical Coherence Tomography Optical Fiber Assembly Capabilities

      OFS , a designer, manufacturer, and supplier of fiber optic products, has introduced new OCT optical fiber assembly capabilities. OFS has developed a technology platform to build optical fiber probes with flexible tip lensing designs to meet critical OCT imaging specifications such as: insertion loss, internal back reflection, beam size and working distance. The company says that because it is vertically integrated with preform (glass) manufacturing, it can make a wide range of fibers with features such as select cutoff, specific numerical apertures, graded index fibers and coreless fibers. Furthermore, polishing and fiber tip shaping skills allow them to assemble custom ...

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    5. Real-time epidural anesthesia guidance using optical coherence tomography needle probe

      Real-time epidural anesthesia guidance using optical coherence tomography needle probe

      Epidural anesthesia is one of the most widely used anesthesia methods. Due to lack of visual feedback to guide needle navigation, failure rate of epidural anesthesia is up to 20%, and the complication rate of peripheral nerve block approaches 10%, with the potential of permanent nerve damage. To address these difficulties, needle insertion under ultrasound guidance and fluoroscopy has been introduced. However, they do not provide adequate resolution and contrast to distinguish the tissue layers that the needle travels through or to specifically identify the epidural space. To improve the accuracy of epidural space identification, we developed a small hand-held ...

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    6. OFS Developes Optical Coherence Tomography Probes for Cardiovascular and GI Applications

      OFS Developes Optical Coherence Tomography  Probes for Cardiovascular and GI Applications

      OFS has been a part of the expanding adaptation of optical coherence tomography (OCT)—dominant in ophthalmology—using miniature optical fiber probes to see deep inside the body. The growth of applications, including cardiology, oncology, and gastroenterology, demonstrate the viability of the technology and the ultimate aim of improving our standard of healthcare. Optical Fiber Probes Supporting the adoption of OCT, OFS has developed the technology platform needed to build high quality optical fiber probes, with flexible tip lensing designs for b

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    7. Integrated Ultrasound And Optical Coherence Tomography (OCT) Endoscope For Image Guided Cancer Biopsy - Available technology for licensing from the University of California, Irvine

      Integrated Ultrasound And Optical Coherence Tomography (OCT) Endoscope For Image Guided Cancer Biopsy - Available technology for licensing from the University of California, Irvine

      Gastrointestinal cancers are very difficult to diagnosis due to poor biopsy and diagnosis techniques. The invention is a device that is minimally invasive and improves biopsy technique by enabling the physician to visualize a tissue in real time prior to its biopsy. This allows for improved biopsy collection and thereby increases the diagnosis accuracy. FULL DESCRIPTION Gastrointestinal (GI) cancers cause 140,000 deaths and more than 290,000 new cases in the US in 2014. These include esophageal, colorectal cancer and many others. The current standard for early diagnosis of GI cancers is to perform histological analysis based on biopsy ...

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    8. Innoluce 2.5 mm Forward Looking OCT Catheter

      Innoluce 2.5 mm Forward Looking OCT Catheter

      A next step in forward looking OCT catheters has been made by Innoluce. A miniaturized MEMS mirror in the tip of the catheter allows for a forward looking OCT scan with a B-scan dimension of ~5mm. The catheter is designed to be used in liquid environment, to be started within the Bladder for cancer diagnostics, but other locations in the body are also possible. First OCT scans of a finger tip with the components showed already a good OCT image quality. Final assembly of the first forward looking OCT catheters is planned for the coming months. At the Photonics West ...

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      Mentions: Innoluce
    9. Research Associate / Research Fellow Microscope In A Needle at the University of Western Australia

      Research Associate / Research Fellow Microscope In A Needle at the University of Western Australia

      The SCHOOL OF ELECTRICAL, ELECTRONIC & COMPUTER ENGINEERING OPTICAL+BIOMEDICAL ENGINEERING LABORATORY 2 year appointment Salary range: Level A $63,332 - $85,942 p.a. or Level B $90,468 - $107,431 p.a. (dependent on qualifications and experience) Research & Development In Biomedical Photonics (Australia) The University of Western Australia (UWA) is a member of Australia's prestigious Group of Eight and ranked among the top 100 universities (88th in the world) with a broad and balanced coverage of disciplines in the arts, sciences and major professions. Could you build, maintain or deploy a state-of-the-art medical imaging instrument? Come join a ...

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    10. Real-time automated thickness measurement of the in vivo human tympanic membrane using optical coherence tomography

      Real-time automated thickness measurement of the in vivo human tympanic membrane using optical coherence tomography

      Background: Otitis media (OM), an infection in the middle ear, is extremely common in the pediatric population. Current gold-standard methods for diagnosis include otoscopy for visualizing the surface features of the tympanic membrane (TM) and making qualitative assessments to determine middle ear content. OM typically presents as an acute infection, but can progress to chronic OM, and after numerous infections and antibiotic treatments over the course of many months, this disease is often treated by surgically inserting small tubes in the TM to relieve pressure, enable drainage, and provide aeration to the middle ear. Diagnosis and monitoring of OM is ...

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    11. In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe

      In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe

      We report multimodal imaging of human oral cavity in vivo based on simultaneous wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography (PS-OCT) with a forward-viewing imaging probe. Wide-field reflectance/fluorescence imaging and PS-OCT were to provide both morphological and fluorescence information on the surface, and structural and birefringent information below the surface respectively. The forward-viewing probe was designed to access the oral cavity through the mouth with dimensions of approximately 10 mm in diameter and 180 mm in length. The probe had field of view (FOV) of approximately 5.5 mm in diameter, and adjustable depth of field (DOF ...

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    12. Injection-depth-locking axial motion guided handheld micro-injector using CP-SSOCT

      Injection-depth-locking axial motion guided handheld micro-injector using CP-SSOCT

      This paper presents a handheld micro-injector system using common-path swept source optical coherence tomography (CP-SSOCT) as a distal sensor with highly accurate injection-depth-locking. To achieve real-time, highly precise, and intuitive freehand control, the system used graphics processing unit (GPU) to process the oversampled OCT signal with high throughput and a smart customized motion monitoring control algorithm. A performance evaluation was conducted with 60-insertions and fluorescein dye injection tests to show how accurately the system can guide the needle and lock to the target depth. The evaluation tests show our system can guide the injection needle into the desired depth with ...

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    13. Johns Hopkins University Receives NIH Grant for OCT-Guided Free-Hand Semi-Automated Microsurgical Tool for Enhanced Retinal Surgery.

      Johns Hopkins University Receives NIH Grant for OCT-Guided Free-Hand Semi-Automated Microsurgical Tool for Enhanced Retinal Surgery.

      Johns Hopkins University Receives a 2014 NIH Grant for $91,945 for OCT-Guided Free-Hand Semi-Automated Microsurgical Tool for Enhanced Retinal Surgery. The principal investigator is Jin U. Kang. The program began in 2011 and ends in 2016. Below is a summary of the proposed work. Contemporary retinal microsurgery is performed by skilled surgeons through operating microscopes, utilizing free hand techniques and manually operated precision micro-instruments. We have assembled an interdisciplinary team including a clinician scientist and vitreoretinal surgeon, an optical device scientist and a systems integrator to translate existing and developing technology in our laboratories into practical application. To this ...

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    14. MEMS scanning micromirror for optical coherence tomography

      MEMS scanning micromirror for optical coherence tomography

      This paper describes an endoscopic-inspired imaging system employing a micro-electromechanical system (MEMS) micromirror scanner to achieve beam scanning for optical coherence tomography (OCT) imaging. Miniaturization of a scanning mirror using MEMS technology can allow a fully functional imaging probe to be contained in a package sufficiently small for utilization in a working channel of a standard gastroesophageal endoscope. This work employs advanced image processing techniques to enhance the images acquired using the MEMS scanner to correct non-idealities in mirror performance. The experimental results demonstrate the effectiveness of the proposed technique.

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    15. Chemical Strategies for the Development of Multimodal Imaging Probes Using Nanoparticles (Book Chapter)

      Chemical Strategies for the Development of Multimodal Imaging Probes Using Nanoparticles (Book Chapter)

      This chapter focuses on the most recently reported nanoparticle agents that have been demonstrated in vivo . It describes the general methods of chemical conjugations, silanisation, and electrostatic adsorption. The chapter examines the recent use of nanoparticles that incorporate a fluorescent dye and a magnetic nanoparticle together. The combination of near-infrared (NIR) and magnetic resonance imaging (MRI) modalities and in vivo characterisation has been executed in two ways: attaching an organic NIR dye to a superparamagnetic iron oxide nanoparticle (SPION); and combining SPIONs with a materials-based NIR fluorescent species such as a quantum dot or multilayered gold/silica nanoparticles. Upconversion luminescence ...

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    16. Fiber-needle Swept-source Optical Coherence Tomography System for the Identification of the Epidural Space in Piglets

      Fiber-needle Swept-source Optical Coherence Tomography System for the Identification of the Epidural Space in Piglets

      Background: Epidural needle insertion is traditionally a blind technique whose success depends on the experience of the operator. The authors describe a novel method using a fiber-needle-based swept-source optical coherence tomography (SSOCT) to identify epidural space. Methods: An optical fiber probe was placed into a hollow 18-gauge Tuohy needle. It was then inserted by an experienced anesthesiologist to continuously construct a series of two-dimensional SSOCT images by mechanically rotating the optical probe. To quantify this observation, both the average SSOCT signal intensities and their diagnostic potentials were assessed. The insertions were performed three times into both the lumbar and thoracic ...

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      Mentions: Wen-Chuan Kuo
    17. MEMS-Based Handheld Fourier Domain Doppler Optical Coherence Tomography for Intraoperative Microvascular Anastomosis Imaging

      MEMS-Based Handheld Fourier Domain Doppler Optical Coherence Tomography for Intraoperative Microvascular Anastomosis Imaging

      Purpose To demonstrate the feasibility of a miniature handheld optical coherence tomography (OCT) imager for real time intraoperative vascular patency evaluation in the setting of super-microsurgical vessel anastomosis. Methods A novel handheld imager Fourier domain Doppler optical coherence tomography based on a 1.3-µm central wavelength swept source for extravascular imaging was developed. The imager was minimized through the adoption of a 2.4-mm diameter microelectromechanical systems (MEMS) scanning mirror, additionally a 12.7-mm diameter lens system was designed and combined with the MEMS mirror to achieve a small form factor that optimize functionality as a handheld extravascular OCT ...

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    18. Hand scanning optical coherence tomography imaging using encoder feedback

      Hand scanning optical coherence tomography imaging using encoder feedback

      We present a new method for generating micron-scale OCT images of interstitial tissue with a hand scanning probe and a linear optical encoder that senses probe movement relative to a fixed reference point, i.e., tissue surface. Based on this approach, we demonstrate high resolution optical imaging of biological tissues through a very long biopsy needle. Minor artifacts caused by tissue noncompliance are corrected using a software algorithm which detects the simple repetition of the adjacent A-scans. This hand-scanning OCT imaging approach offers the physician the freedom to access imaging sites of interest repeatedly.

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    19. Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging

      Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging

      In this Letter, we present a trimodality imaging system and an intravascular endoscopic probe for the detection of early-stage atherosclerotic plaques. The integrated system is able to acquire optical coherence tomography (OCT), fluorescence, and ultrasound images and simultaneously display them in real time. A trimodality intravascular endoscopic probe of 1.2 mm in diameter and 7 mm in length was fabricated based on a dual-modality optical probe that integrates OCT and fluorescence imaging functions and a miniature ultrasound transducer. The probe is capable of rotating at up to 600 rpm. Ex vivo images from rabbit aorta and human coronary arteries ...

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    20. Low coherence interferometry approach for aiding fine needle aspiration biopsie

      Low coherence interferometry approach for aiding fine needle aspiration biopsie

      We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation. Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.

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    21. Characterization and micro-assembly of electrostatic actuators for 3-DOF micromanipulators in laser phonomicrosurgery

      Characterization and micro-assembly of electrostatic actuators for 3-DOF micromanipulators in laser phonomicrosurgery

      This paper presents a design of electrostatic actuators for 3-DOF micromanipulators in robot-assisted laser phonomicrosurgery. By integrating three sets of electrostatic actuators in a vertical configuration, scanning micro-mirror can be used as a manipulator for laser source. Key enable technology for these miniaturized actuators is microfabrication processes for microelectromechanical systems (MEMS) because the processes can create submicron features with high precision, mass productive, and low cost. Based on precise micromachined electrostatic actuators, the platform is assembled using micro assembly approach. With sizes less than 5 mm × 5 mm × 5 mm, the proposed design has three degree-of-freedom: two rotational motions around ...

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    1-24 of 404 1 2 3 4 ... 15 16 17 »
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    1. (1 articles) Dirk J. Faber
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