Popular Articles
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OCT Products in the News
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Organizations in the News
(12 articles) University of Florida
(12 articles) Johns Hopkins University
(7 articles) Massachusetts Institute of Technology
(6 articles) Harvard University
(5 articles) Gwangju Institute of Science and Technology
(5 articles) Massachusetts General Hospital
(4 articles) National University of Singapore
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Method and apparatus for measurement of optical properties in tissue
Explore Article uspto.gov (Aug 31 2010)
A method of analyzing tissue includes inserting a radiation source into tissue, impinging radiation upon the tissue, obtaining a sample signal of the radiation that impinges upon the tissue, and determining a refractive index of the tissue from the sample signal. The method may also include determining at least one other optical property of the tissue. The method may provide for identifying tissue as part of a biopsy method. A device for analyzing tissue may include a low-coherence interferometer and a probe optically coupled to the interferometer, where the probe includes a radiation source.
Comment on Article Mentions: Stephen A. Boppart Julian J. Armstrong David D. Sampson
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Robust High-Resolution Fine OCT Needle for Side-Viewing Interstitial Tissue Imaging
Explore Article IEEE Xplore (Aug 9 2010)
Fine optical coherence tomography (OCT) imaging needles that can be integrated with a standard biopsy needle have been developed with a new optics design to improve the optical quality and mechanical robustness, where a fiber-optic lens (that is spliced to a single-mode fiber) and a microreflector are encased within a microglass tube. The design also minimizes the cylindrical lens effect induced by the glass tube and eases the needle assembly process. Real-time cross-sectional OCT imaging of various tissue samples were performed ex vivo using the miniature-imaging needle along with a 1300-nm swept-source OCT system. The preliminary results demonstrate the improved ...
Comment on Article Mentions: Johns Hopkins University University of Washington Joo Ha Hwang
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Endoscopic Functional Fourier Domain Common-Path Optical Coherence Tomography for Microsurgery
Explore Article IEEE Xplore (Aug 9 2010)
A single-arm interferometer-based optical coherence tomography (OCT) system known as common-path OCT (CP-OCT) is rapidly progressing towards practical application. Due in part to the simplicity and robustness of its design, Fourier domain CP-OCT (FD-CP-OCT) offers advantages in many endoscopic sensing and imaging applications. FD-CP-OCT uses simple, interchangeable fiber optic probes that are easily integrated into small and delicate surgical tools. The system is capable of providing not only high-resolution imaging but also optical sensing. Here, we report progress towards practical application of FD-CP-OCT in the setting of delicate microsurgical procedures such as intraocular retinal surgery. To meet the challenges presented ...
Comment on Article Mentions: Johns Hopkins University Jin U. Kang Kang Zhang
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In-vivo dynamic characterization of microneedle skin penetration using optical coherence tomography
Explore Article SPIE Digital Library (Aug 6 2010)
The use of microneedles as a method of circumventing the barrier properties of the stratum corneum is receiving much attention. Although skin disruption technologies and subsequent transdermal diffusion rates are being extensively studied, no accurate data on depth and closure kinetics of microneedle-induced skin pores are available, primarily due to the cumbersome techniques currently required for skin analysis. We report on the first use of optical coherence tomography technology to image microneedle penetration in real time and in vivo. We show that optical coherence tomography (OCT) can be used to painlessly measure stratum corneum and epidermis thickness, as well as ...
Comment on Article Mentions: University of Limerick
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Miniature Non-MEMS Scanner For Small Size Imaging Systems
Explore Article Photonics Online (Aug 2 2010)
The SMALLEST available non-MEMS Resonant Scanner currently on the market was developed by Electro-Optical Products Corp. is a miniature electromagnetically driven moving mirror device (0.9 x 0.5 x 0.4 inches), which deflects a light beam with a continuous sinusoidal motion. EOPC's technology offers 6 mm diameter, 7x7 mm and 12x7 mm size mirrors, with an optical scanning angle up to 50°, and a fixed-frequency scanning range from 100 to 1000 Hz, fixed at any one value within the range. AGC type driver provides: •both sine wave and TTL level square wave reference signals •trimpot control to adjust the phase of ...
Comment on Article Mentions: Electro-Optical Products Corporation
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System and method for identifying tissue using low-coherence interferometry
Explore Article uspto.gov (Jul 20 2010)
An apparatus for needle biopsy with real time tissue differentiation using one dimensional interferometric ranging imaging, comprising a biopsy device having a barrel and a needle, an optical fiber inserted in the needle, and a fiber optic imaging system connected to the optical fiber. The imaging system obtains images and compares the optical properties and patterns to a database of normalized tissue sample images to determine different tissue types. The physician performing the biopsy obtains feedback via a feedback unit associated with the biopsy device and which is connected to the imaging system. The feedback unit can provide visual, audible ...
Comment on Article Mentions: Guillermo J. Tearney Brett E. Bouma Massachusetts General Hospital
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Interference objective for annular test surfaces
Explore Article uspto.gov (Jul 6 2010)
An apparatus including: an interferometric objective comprising a beam splitter surface configured to separate input light into test light and reference light, and a reference surface configured to receive the reference light and direct it back to the beam splitter surface, which is configured to recombine the reference light with test light reflected from a test surface, the interferometric objective further comprising one or more optical elements positioned in the path of the input light and having positive or negative optical power, wherein the reference surface is curved and defines a window to pass the input light towards the beam ...
Comment on Article Mentions: Zygo
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Forward-viewing resonant fiber-optic scanning endoscope of appropriate scanning speed for 3D OCT imaging
Explore Article opticsinfobase.org (Jun 21 2010)
A forward-viewing resonant fiber-optic endoscope of a scanning speed appropriate for a high-speed Fourier-domain optical coherence tomography (FD-OCT) system was developed to enable real-time, three-dimensional endoscopic OCT imaging. A new method was explored to conveniently tune the scanning frequency of a resonant fiber-optic scanner, by properly selecting the fiber-optic cantilever length, partially changing the mechanical property of the cantilever, and adding a weight to the cantilever tip. Systematic analyses indicated the resonant scanning frequency can be tuned over two orders of magnitude spanning from ~10Hz to ~kHz. Such a flexible scanning frequency range makes it possible to set an appropriate ...
Comment on Article Mentions: Xingde Li Johns Hopkins University
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Atherectomy system with imaging guidewire
Explore Article uspto.gov (Jun 8 2010)
Systems and methods of increasing blood flow in a blood vessel with ultraluminal plaque. One disclosed method includes inserting an imaging guidewire into the blood vessel to the intraluminal plaque, propelling a catheter with a working head over the guidewire towards the distal end of the guidewire, scanning with the imaging guidewire to generate a cross-section image, radially positioning the catheter using a positioning element, monitoring the image to ascertain that the working head is properly positioned and operating the working head to remove the plaque. A computerized system designed, constructed and configured to perform the methods is further disclosed.
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Optical scanning system
Explore Article uspto.gov (Jun 8 2010)
The present application is directed to an optical scanning system for medical applications, preferably in ophthalmology, which can be used for a large range of diagnostic and therapeutic applications. The optical scanning system comprises at least one controllable reflector which has an actuator and which is arranged in a first imaging beam path for deflecting at least one therapy beam and/or diagnosis beam over a work field in a scanning manner, a second imaging beam path for a fixation beam which is imaged on the work field in a spatially fixed manner with respect to the optical axis of the ...
Comment on Article Mentions: Carl Zeiss Meditec
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Volcano Introduces Vibe™ Rx - the World's Only Vascular Imaging Balloon Catheter
Explore Article PR Newswire (May 26 2010)
Volcano Corporation (NASDAQ: VOLC) announced today that it has received CE Mark approval for the VIBE™ RX Vascular Imaging Balloon Catheter. The company also announced that it has completed its first clinical cases with the VIBE™ RX in New Zealand. A single VIBE™ RX Catheter can quickly access, prepare, and assess challenging lesions. IVUS guidance provides precise, targeted balloon dilatation with immediate confirmation of interventional results. "VIBE™ RX represents the first of what we believe will be many Volcano image-guided therapy devices designed to allow physicians to see more detail right at the point of the therapy," commented Scott Huennekens, ...
Comment on Article Mentions: John A. Ormiston Scott Huennekens Volcano
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Access system
Explore Article uspto.gov (May 25 2010)
The invention provides systems and methods for providing access to a target site. Example systems may include a needle, a grid to guide the needle, a plate with an aperture, a member coupled to the plate and including a semispherical surface, and a hub slideably coupled to the plate by a guide. The system may also include a needle coupled to the hub, the needle including a magnetically trackable sensor positioned in a tip of the needle. The semispherical surface can be positioned against skin of a body and the hub slid relative to the plate along the guide to ...
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3D In Vivo optical coherence tomography based on a low-voltage, large-scan-range 2D MEMS mirror
Explore Article opticsinfobase.org (May 24 2010)
3D in vivo optical imaging on a mouse has been obtained using a 2D MEMS mirror for lateral scanning in a time-domain optical coherence tomography (OCT) system. The MEMS mirror aperture size is 1 × 1 mm2, and the device footprint is 2 × 2 mm2. The MEMS mirror scans ± 30° optical angles about both x and y-axis at only 5.5V DC voltage. An endoscopic probe with an outer diameter of 5.8 mm has been designed, manufactured and packaged. The probe scans an average transverse area of 2 mm × 2 mm. The imaging speed of the probe is ...
Comment on Article Mentions: Lei Wu Huikai Xie Shuguang Guo
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Catheter imaging probe and method
Explore Article uspto.gov (May 4 2010)
A catheter imaging probe for a patient. The probe includes a conduit through which energy is transmitted. The probe includes a first portion through which the conduit extends. The probe includes a second portion which rotates relative to the conduit to redirect the energy from the conduit. A method for imaging a patient. The method includes the steps of inserting a catheter into the patient. There is the step of rotating a second portion of the catheter relative to a conduit extending through a first portion of the catheter, which redirects the energy transmitted through the conduit to the patient ...
Comment on Article Mentions: Thomas E. Milner Volcano Marc D. Feldman
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Looking for a new generation of MEMS-type confocal microscopes
Explore Article SpringerLink Home (Apr 28 2010)
In the field of optical scanning microscopy the micro-scale or nano-scale samples are observed and analysed via large macro-tools, too bulky and heavy for individual use in specialised key missions such as in situ or in vivo measuring. A need for compact, robust scanning devices for endoscopic applications has stimulated the development of MEMS scanning mirrors for confocal imaging and for optical coherence tomography. The architecture of proposed on-chip confocal microscope is shown in Fig. 1 [1]. The individual microscope consists of two microlens scanner chips, a beamsplitter, a PIN detector and a pinhole aperture. The microlens scanner chips have ...
Comment on Article Mentions: FEMTO-ST Institute
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