1. Articles in category: Probes

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    1. Imaging catheter system

      Imaging catheter system

      Disclosed is an imaging catheter system that utilizes optical coherence tomography and autofluorescence lifetime imaging microscopy. The disclosed imaging catheter system may include: an autofluorescence light source; an OCT device; a catheter device configured to receive rays inputted from the autofluorescence light source and an OCT light source of the OCT device and scan a specimen; an optical detector unit configured to detect autofluorescence generated from the specimen; and a first optics system configured to transfer the autofluorescence to the optical detector unit and transfer a ray of the OCT light source reflected from the specimen to the OCT device.

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    2. Apparatus and method for assessment of interstitial tissue

      Apparatus and method for assessment of interstitial tissue

      A handheld optical coherence tomography imaging and tissue sampling system and method of imaging and sampling a tissue is disclosed. The method includes inserting a catheter probe into a biopsy needle. The biopsy needle can be attached to a hand-held scanning and sampling device. The biopsy needle is maneuvered to an investigation site. A three-dimensional image of the tissue at the investigation site is captured with the catheter probe.

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    3. Real-time needle guidance for venipuncture based on optical coherence tomography

      Real-time needle guidance for venipuncture based on optical coherence tomography

      An algorithm for real–time venipuncture needle guidance is described, using an optical coherence tomography (OCT) probe that emits light pulses at fixed angular intervals along a cone, giving accurate distance measurements to points on the blood vessel. Using this data, a method is developed to visually display the blood vessel for needle guidance. A least–squares fit to a general quadric surface, specified by a symmetric matrix, is performed. For a cylindrical blood vessel, this provides an estimate for its orientation, from which its location and radius can be determined. The algorithm is compatible, in efficiency and robustness, with ...

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      Mentions: UC Davis
    4. All-fiber probes for endoscopic optical coherence tomography of the large airways

      All-fiber probes for endoscopic optical coherence tomography of the large airways

      Endoscopic optical coherence tomography of large airways poses unique challenges. A hybrid lens is described that consists of a section of coreless fiber and graded index fiber (GIF), followed by a ball lens section. This design produces low numerical aperture beams better suited for large airway imaging. The performance of this lens is compared against conventional GIF and ball lens designs. Forward- and side-viewing probes were modeled, fabricated, and tested. The impact of a sheath on the beam profile was also investigated. Probes with working distances larger than 10 mm and depth-of-focus exceeding 12 mm are demonstrated with the proposed ...

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    5. Data Stream Stabilization for Optical Coherence Tomography Volumetric Scanning

      Data Stream Stabilization for Optical Coherence Tomography Volumetric Scanning

      Optical Coherence Tomography (OCT) is an emerging medical imaging modality for luminal organ diagnosis. The non-constant rotation speed of optical components in the OCT catheter tip causes rotational distortion in OCT volumetric scanning. By improving the scanning process, this instability can be partially reduced. To further correct the rotational distortion in the OCT image, a volumetric data stabilization algorithm is proposed. The algorithm first estimates the Non-Uniform Rotational Distortion (NURD) for each B-scan by using a Convolutional Neural Network (CNN). A correlation map between two successive B-scans is computed and provided as input to the CNN. To solve the problem ...

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    6. Imaging the small with the small: Prospects for photonics in micro-endomicroscopy for minimally invasive cellular-resolution bioimaging

      Imaging the small with the small: Prospects for photonics in micro-endomicroscopy for minimally invasive cellular-resolution bioimaging

      Many bioimaging studies, including those in engineered tissue constructs, intravital microscopy in animal models, and medical imaging in humans, require cellular-resolution imaging of structures deep within a sample. Yet, many of the current approaches are limited in terms of resolution, but also in invasiveness, repeatable imaging of the same location, and accessible imaging depth. We coin the term micro-endomicroscope to describe the emerging class of small, cellular-resolution endoscopic imaging systems designed to image cells in situ while minimizing perturbation of the sample. In this Perspective, we motivate the need for further development of micro-endomicroscopes, highlighting applications that would greatly benefit ...

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    7. Apparatus and method for maintaining precise end-to-end relative position between two optical fibers

      Apparatus and method for maintaining precise end-to-end relative position between two optical fibers

      According to at least one embodiment of the present disclosure, there is provided an apparatus comprising: a first optical fiber in communication with a light source; a second optical fiber in communication with an imaging probe; and a fiber optic rotary joint (FORJ) where a distal end of the first optical fiber and a proximal end of the second optical fiber are positioned coaxially with a gap between the fibers' end faces. The FORJ is adapted to transmit light between the fibers' end faces, and to rotate at least one of first and second optical fibers relative to the other ...

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    8. Physical Sciences, Inc Receives NIH Grant for Multimodal Optical Prove for Skin Cancer Detection and Therapy Guidance

      Physical Sciences, Inc Receives NIH Grant for Multimodal Optical Prove for Skin Cancer Detection and Therapy Guidance

      Physical Sciences, Inc Receives a 2021 NIH Grant for $742,473 for Multimodal Optical Prove for Skin Cancer Detection and Therapy Guidance. The principal investigator is Nicusor Iftima. Below is a summary of the proposed work. The primary goal of this research project is to develop and translate to clinical use a novel optical imaging technology based on combined Optical Coherence Tomography (OCT) and Confocal Microscopy (CM) for non- invasive real-time diagnosis of non-melanoma skin cancers (NMSCs), tumor subtyping and margin mapping that will assist physician-patient decision in treatment planning (biopsy vs. no biopsy, surgery vs. non-surgical), as well as ...

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    9. Micro-molded anamorphic reflector lens for image guided therapeutic/diagnostic catheters

      Micro-molded anamorphic reflector lens for image guided therapeutic/diagnostic catheters

      A catheter system for optical coherence tomography includes an elongate catheter body, an optical fiber in the elongate catheter body, and an anamorphic lens assembly coupled with a distal end of the optical fiber. The optical fiber and the lens assembly are together configured to provide a common path for optical radiation reflected from a target and from a reference interface between the distal end of the optical fiber and the lens assembly.

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      Mentions: Avinger
    10. Multi-functional handheld optical coherence tomography imaging system

      Multi-functional handheld optical coherence tomography imaging system

      An OCT (Optical Coherence Tomography) handheld device is provided comprising: a housing configured for handheld OCT scanning during a surgical procedure, the housing comprising an OCT scanning end and a proximal end opposite the OCT scanning end; an OCT scanning device inside the housing, the OCT scanning device configured for one or more of OCT polarized scanning and Doppler OCT scanning from the OCT scanning end, the OCT scanning device further configured to receive and convey OCT light between the proximal end and an OCT analysing system; and a tip extending from the OCT scanning end, the tip being removably ...

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    11. Multi-channel optical fiber rotary junction

      Multi-channel optical fiber rotary junction

      Exemplary apparatus, systems, methods of making, and methods of using a rotary junction are provided. A rotary junction having multiple channels is provided herein. The rotary junction has a first coupling optic and a second coupling optic where the rotating optical fiber or other waveguide comping from the first coupling optic passes through the second coupling optics. 5271076 December 1993 5287423 February 1994 Anthony 5337734 August 1994 5347990 September 1994 Ebling et al.

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    12. Forward-imaging optical coherence tomography probe

      Forward-imaging optical coherence tomography probe

      A forward-imaging optical coherence tomography probe is provided, comprising: a substantially cylindrical housing comprising: a longitudinal axis; an interior side; a distal end that is optically transparent; and a mirror located at the interior side, adjacent the distal end; an optical fiber located inside the cylindrical housing along the longitudinal axis; a wedge lens located inside the cylindrical housing, adjacent the distal end, the wedge lens configured to receive light from the fiber, and direct the light towards the mirror; and, at least one motor configured to both: rotate the fiber and the wedge lens about the longitudinal axis and ...

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    13. High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source

      High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source

      Optical coherence tomography (OCT) and OCT angiography (OCTA) enable noninvasive structural and angiographic imaging of the eye. Portable handheld OCT/OCTA systems are required for imaging patients in the supine position. Examples include infants in the neonatal intensive care unit (NICU) and operating room (OR). The speed of image acquisition plays a pivotal role in acquiring high-quality OCT/OCTA images, particularly with the handheld system, since both the operator hand tremor and subject motion can cause significant motion artifacts. In addition, having a large field of view and the ability of real-time data visualization are critical elements in rapid disease ...

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    14. MEMS swept-wavelength laser enables new OCT capabilities

      MEMS swept-wavelength laser enables new OCT capabilities

      Optical interferometry is sensitive and noninvasive, making optical coherence tomography (OCT) a valuable clinical diagnostic tool. OCT directs light to a target tissue, detects the reflection, and processes the reflection to reconstruct an image of subsurface structures. Although powerful, long acquisition times make some endoscopic imaging either impractical or impossible. The key to enabling new applications is to increase the A-scan speed—the acquisition speed of the depth profile at a single location. In swept-source OCT (SS-OCT), a light beam sweeps through a range of wavelengths and the reflected signal is processed to recover a depth profile at that point ...

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    15. A spatial resolution evaluation method of endoscopic optical coherence tomography system using the annular phantom

      A spatial resolution evaluation method of endoscopic optical coherence tomography system using the annular phantom

      As an important biomedical imaging method, endoscopic optical coherence tomography (OCT) is necessary to check its performance regularly. The ordinary plane phantoms are only able to evaluate part of image tangent to the probe. In this research, a spatial resolution estimate method of the endoscope OCT system is proposed. The annular phantom, made by uniformly distributing golden scattered microparticles in polydimethylsiloxane (PDMS), can provide dynamic scanning imaging evaluation of endoscopic OCT system, closer to its actual working status. The point spread function (PSF) analysis method is used to analyze the imaging results of the annular phantom with the endoscopic OCT ...

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    16. Super-Achromatic Rapid Scanning Microendoscope for Ultrahigh-Resolution OCT Imaging

      Super-Achromatic Rapid Scanning Microendoscope for Ultrahigh-Resolution OCT Imaging

      Microendoscope is a critical technology to enable high-resolution imaging of internal luminal organs with optical coherence tomography. This paper reports the development of an achromatic compound microlens and a rapid scanning microendoscope based on the microlens that offers an ultrahigh transverse resolution of 4 mum (and an axial resolution of 2.2 mum when using a low-coherence light source with a broad spectrum bandwidth of 150 nm). The rapid scanning endoscope is capable of ultrahigh-resolution (UHR) optical coherence tomography (OCT) imaging in real time at an imaging speed of about 1220 lateral scans/s, with the image quality comparable to ...

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    17. Few-mode fiber endoscope

      Few-mode fiber endoscope

      Disclosed herein are configurations for few-mode fiber optical endoscope systems employing distal optics and few-mode, double-clad or other optical fiber wherein the systems directing an optical beam to a sample via the optical fiber; collecting light backscattered from the sample; direct the backscattered light to a detector via the optical fiber; and detect the backscattered light; wherein the directed optical beam is single mode and the collected light is one or more higher order modes.

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    18. Multi-MHz MEMS-VCSEL swept-source optical coherence tomography for endoscopic structural and angiographic imaging with miniaturized brushless motor probes

      Multi-MHz MEMS-VCSEL swept-source optical coherence tomography for endoscopic structural and angiographic imaging with miniaturized brushless motor probes

      Swept source optical coherence tomography (SS-OCT) enables volumetric imaging of subsurface structure. However, applications requiring wide fields of view (FOV), rapid imaging, and higher resolutions have been challenging because multi-MHz axial scan (A-scan) rates are needed. We describe a microelectromechanical systems vertical cavity surface-emitting laser (MEMS-VCSEL) SS-OCT technology for A-scan rates of 2.4 and 3.0 MHz. Sweep to sweep calibration and resampling are performed using dual channel acquisition of the OCT signal and a Mach Zehnder interferometer signal, overcoming inherent optical clock limitations and enabling higher performance. We demonstrate ultrahigh speed structural SS-OCT and OCT angiography (OCTA) imaging ...

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    19. Multi-MHz MEMS-VCSEL swept-source optical coherence tomography for endoscopic structural ...

      Multi-MHz MEMS-VCSEL swept-source optical coherence tomography for endoscopic structural ...

      Swept source optical coherence tomography (SS-OCT) enables volumetric imaging of subsurface structure. However, applications requiring wide fields of view (FOV), rapid imaging, and higher resolutions have been challenging because multi-MHz axial scan (A-scan) rates are needed. We describe a microelectromechanical systems vertical cavity surface-emitting laser (MEMS-VCSEL) SS-OCT technology for A-scan rates of 2.4 and 3.0 MHz. Sweep to sweep calibration and resampling are performed using dual channel acquisition of the OCT signal and a Mach Zehnder interferometer signal, overcoming inherent optical clock limitations and enabling higher performance. We demonstrate ultrahigh speed structural SS-OCT and OCT angiography (OCTA) imaging ...

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    20. Modeling, optimization, and validation of an extended-depth-of-field optical coherence tomography probe based on a mirror tunnel

      Modeling, optimization, and validation of an extended-depth-of-field optical coherence tomography probe based on a mirror tunnel

      The diagnostic capability of high-resolution optical coherence tomography (OCT) may be enhanced by using extended depth-of-field (EDOF) imaging that retains high transverse resolution over long depths. A recently developed mirror-tunnel optical probe design (single-mode fiber to multimode fiber to lens structure) that generates coaxially focused modes has been previously shown to enable EDOF for endoscopic OCT applications. Here, we present ray-tracing optical modeling of this optical configuration, which has the potential to guide performance improvement through optimization. The Huygens wave propagation of the field was traced through probe components with initial lengths. The irradiance along the

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    21. Long-term in vivo monitoring of gliotic sheathing of ultrathin entropic coated brain microprobes with fiber-based optical coherence tomography

      Long-term in vivo monitoring of gliotic sheathing of ultrathin entropic coated brain microprobes with fiber-based optical coherence tomography

      Microfabricated neuroprosthetic devices have made possible important observations on neuron activity; however, long-term high-fidelity recording performance of these devices has yet to be realized. Tissue-device interactions appear to be a primary source of lost recording performance. The current state of the art for visualizing the tissue response surrounding brain implants in animals is Immunohistochemistry + Confocal Microscopy, which is mainly performed after sacrificing the animal. Monitoring the tissue response as it develops could reveal important features of the response which may inform improvements in electrode design. Optical Coherence Tomography (OCT), an imaging technique commonly used in ophthalmology, has already been adapted ...

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    22. Tethered capsule provides high-quality images for Barrett’s esophagus

      Tethered capsule provides high-quality images for Barrett’s esophagus

      Researchers were able obtain high-quality images of Barrett’s esophagus using tethered capsule endomicroscopy, according to study results. Guillermo Tearney , MD, PhD, from the Wellman Center for Photomedicine at Massachusetts General Hospital, and colleagues wrote that the capsule, which uses optical coherence tomography, (OCT-TCE) provides 3D microscopic images of the esophagus for BE. “OCT-TCE does not require sedation, obtains microscopic images of the entire esophagus, and is a faster and more convenient procedure,” they wrote. “Our group and others have successfully conducted OCT-TCE in pilot, single-center studies showing exemplary images that demonstrate the potential of this technology to improve upper ...

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    23. Optical measurement system using multicore optical fiber

      Optical measurement system using multicore optical fiber

      An optical-fiber measurement system includes an optical system that generates light and a spatial optical switch that is coupled to the optical system that processes the light generated by the optical system and generates light at a plurality of spatially distributed optical ports. A respective one of a plurality of optical cores at a first end of a multicore optical fiber is positioned to receive light from a respective one of the plurality of spatially distributed optical ports, where the light generated at the plurality of spatially distributed optical ports propagates through the multicore optical fiber. Distal optics is positioned ...

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    24. Fiber optic rotary joints and methods of using and manufacturing same

      Fiber optic rotary joints and methods of using and manufacturing same

      One or more fiber optic rotary joints (FORJ), free space beam combiners, OCT, SEE and/or fluorescence devices and systems for use therewith, methods of manufacturing same and storage mediums are provided. One or more embodiments of FORJs may be used with numerous applications in the optical field, including, but not limited to, OCT and fluorescence applications. Examples of such applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for Gastro-intestinal, cardio and/or ophthalmic applications, and being obtained via one or more optical instruments.

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