Tunable Sources -Optical Coherence Tomography News

Articles in category: Tunable Sources

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1. VIS-OCT needs stable, versatile light sources
  
  Explore Photonics.com Nov 19 2020 Broadband Sources , Tunable Sources
  
  Optical coherence tomography (OCT) is the gold standard for noninvasive retinal imaging, enabling ophthalmologists to diagnose and treat multiple ocular diseases. Compared to traditional OCT, which uses near-infrared (NIR) wavelengths of light, visible-light OCT (VIS-OCT) offers superior spatial resolution and novel functional imaging capabilities. VIS-OCT provides the most accurate means for measuring retinal oxygen saturation, a key biomarker for understanding changes in tissue metabolism associated with the pathology of various retinal diseases. Traditional OCT has dominated ophthalmic diagnostics for the past 30 years. Thanks to investment in and development of key OCT components, there is an opportunity to accelerate adoption ...
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  Mentions: Northwestern University Hao F. Zhang Roman V. Kuranov
2. PhD Position Available in Lübeck: Development of an Ultra-Wideband FDML-Laser
  
  Explore Optical Coherence Tomography News Nov 18 2020 Tunable Sources , Jobs & Studentships
  
  We offer a three year PhD student position for an Early Stage Researcher (ESR) on laser development in biomedical optics. The position is part of a Marie Skłodowska-Curie Innovative Training Network (ITN) within the EU Horizon 2020 Framework Programme. It will be within the project NETLAS (https://cordis.europa.eu/project/id/860807), which focuses on innovative solutions for fast, narrow linewidth, phase stable and wide tuning bandwidth swept sources as well as on their application in biomedical optics - especially for optical coherence tomography (OCT).
  
  The position is in the group of Robert Huber at the University of Lübeck ...
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  Mentions: Cordis Robert A. Huber University of Lübeck
3. Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging
  
  Explore OSA | OSA Publishing Nov 11 2020 Tunable Sources
  
  In order to realize adjustable A-scan rates of fast optical coherence tomography (OCT) systems, we investigate averaging of OCT image data acquired with a MHz-OCT system based on a Fourier Domain Mode Locked (FDML) laser. Increased system sensitivity and image quality can be achieved with the same system at the cost of lower imaging speed. Effectively, the A-scan rate can be reduced in software by a freely selectable factor. We demonstrate a detailed technical layout of the strategies necessary to achieve efficient coherent averaging. Since there are many new challenges specific to coherent averaging in swept source MHz-OCT, we analyze ...
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  Mentions: Robert A. Huber University of Lübeck Tom Pfeiffer
4. Linear-in-wavenumber actively-mode-locked wavelength-swept laser
  
  Explore OSA | OSA Publishing Oct 3 2020 Tunable Sources
  
  We report on an akinetic actively-mode-locked wavelength-swept laser (ASL) with a sweep that is highly linear in wavenumber. By tailoring the drive waveform of the intracavity modulator, the wavenumber sweep was further linearized to enable high fidelity frequency-domain interferometric ranging without resampling of the acquired data. Used for catheter-based optical coherence tomography, the ASL showed comparable imaging performance to a state-of-the-art polygon-based wavelength-swept source at a matching sweep rate of 103.6 kHz, a duty cycle of 95%, and a bandwidth of 100 nm, centered at 1330 nm.
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  Mentions: Brett E. Bouma Massachusetts Institute of Technology Massachusetts General Hospital
5. Frequency-doubled FDML-MOPA laser in the visible
  
  Explore OSA | OSA Publishing Jul 7 2020 Tunable Sources
  
  Wavelength-swept lasers enable high-speed measurements in absorption spectroscopy, Raman spectroscopy, nonlinear Raman hyperspectral microscopy, rapid confocal microscopy, short impulse generation, and most importantly for high-speed optical coherence tomography, with speeds up to video-rate volumetric imaging. Recently, we introduced a pulsed wavelength-swept laser based on the Fourier domain mode-locked (FDML) laser principle combined with a master-oscillator power amplifier (MOPA) architecture. The high peak powers reached with this laser enabled rapid two-photon microscopy and two-photon fluorescence lifetime microscopy and high-speed light detection and ranging measurements. Here, we present the extension of this laser into the visible wavelength range by frequency doubling the ...
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  Mentions: University of Lübeck UCLA
6. Stepped frequency comb generation based on electro-optic phase-code mode-locking for moderate-speed circular-ranging OCT
  
  Explore OSA | OSA Publishing Jun 15 2020 Tunable Sources
  
  Circular-ranging (CR) optical coherence tomography (OCT) uses frequency comb sources to improve long-range imaging. While the initial development of CR-OCT focused on extremely high-speed imaging (i.e., operation at A-line rates of several to tens of MHz), there are many applications and imaging strategies for which more moderate speeds are preferred. However, we lack suitable frequency comb sources to enable moderate speed CR-OCT imaging. Here, we describe a novel phase-code mode-locking (PCML) laser architecture that can be operated from the kilohertz to megahertz range, while also offering novel features such as dynamic re-configurability and simplified linear-in-time frequency stepping. We demonstrate ...
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  Mentions: Massachusetts General Hospital Harvard University Benjamin J. Vakoc
7. 9.4 MHz A-line rate optical coherence tomography at 1300 nm using a wavelength-swept laser based on stretched-pulse active mode-locking
  
  Explore Nature Publishing Group Jun 11 2020 Tunable Sources
  
  In optical coherence tomography (OCT), high-speed systems based at 1300 nm are among the most broadly used. Here, we present 9.4 MHz A-line rate OCT system at 1300 nm. A wavelength-swept laser based on stretched-pulse active mode locking (SPML) provides a continuous and linear-in-wavenumber sweep from 1240 nm to 1340 nm, and the OCT system using this light source provides a sensitivity of 98 dB and a single-sided 6-dB roll-off depth of 2.5 mm. We present new capabilities of the 9.4 MHz SPML-OCT system in three microscopy applications. First, we demonstrate high quality OCTA imaging at a ...
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  Mentions: Massachusetts General Hospital Harvard University Wang Yuhl Oh
8. PhD position on tunable lasers for optical coherence tomography at the University of Kent
  
  Explore Optical Coherence Tomography News May 9 2020 Tunable Sources , Jobs & Studentships
  
  We are recruiting for a PhD Studentship in the fields of Optics and Laser Physics, with emphasis on optical coherence tomography for a period of 36 months starting up to 31 January 2021, within the Applied Optics Group, School of Physical Sciences. This is supported by the Marie Curie Innovative Training Network scheme, 860807, EU funded, jointly organised with 14 other universities, companies and hospitals in Europe. You will spend time at the University of Kent and at the other beneficiaries or associated partners. Supervision will be provided in an European setting where specialized and complementary training will be provided ...
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  Mentions: Adrian G. Podoleanu University of Kent
9. Spectrally shaped tunable short-cavity laser
  
  Explore uspto.gov Apr 7 2020 Patents , Tunable Sources
  
  A tunable source includes a short-cavity laser optimized for performance and reliability in SSOCT imaging systems, spectroscopic detection systems, and other types of detection and sensing systems. The short cavity laser has a large free spectral range cavity, fast tuning response and single transverse, longitudinal and polarization mode operation, and includes embodiments for fast and wide tuning, and optimized spectral shaping. Disclosed are both electrical and optical pumping in a MEMS-VCSEL geometry with mirror and gain regions optimized for wide tuning, high output power, and a variety of preferred wavelength ranges; and a semiconductor optical amplifier, combined with the short-cavity ...
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  Mentions: Thorlabs Alex E. Cable Benjamin M. Potsaid
10. Highly Stable All-Fiber-Ring Short-Cavity Continuously Tuned Swept Source
  
  Explore MDPI Open Access Journals Platform Feb 14 2020 Tunable Sources
  
  In this study, we present a swept source that can intelligently control its sweeping speed while satisfying the commercial stability and miniaturization standards. The source’s central wavelength of the output spectrum is 1300 nm and spectral width is greater than 100 nm. Meanwhile, the scan frequency can be adjusted to range from 20 to 100 kHz, and the stability degree of the optical capacity is less than 0.34%. Additionally, this study establishes a numerical model for the swept-source optical coherence tomography (SS–OCT) system and introduces a numerical simulation of the signal produced during the OCT imaging process ...
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11. Resolving absolute depth in circular-ranging optical coherence tomography by using a degenerate frequency comb
  
  Explore OSA | OSA Publishing Jan 12 2020 Tunable Sources
  
  In Fourier-domain optical coherence tomography, an interference signal is generated that spans an RF bandwidth proportional to the product of three parameters: the imaging range, the imaging speed, and the inverse of the axial resolution. Circular-ranging optical coherence tomography (CR-OCT) architectures were introduced to ease long-range imaging by decoupling the imaging range from the signal RF bandwidth. As a consequence, present CR-OCT systems resolve the relative, but not the absolute, depth location of the scatterers. We introduce here a modified implementation of CR-OCT that uses a degenerate frequency comb source that allows recovery of absolute depth information while only minimally ...
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  Mentions: Massachusetts General Hospital Harvard University Benjamin J. Vakoc
12. GaAs-Based InPBi Quantum Dots for High Efficiency Super-Luminescence Diodes
  
  Explore MDPI Open Access Journals Platform Dec 6 2019 Broadband Sources , Tunable Sources
  
  InPBi exhibits broad and strong photoluminescence at room temperature, and is a potential candidate for fabricating super-luminescence diodes applied in optical coherence tomography. In this paper, the strained InPBi quantum dot (QD) embedded in the AlGaAs barrier on a GaAs platform is proposed to enhance the light emission efficiency and further broaden the photoluminescence spectrum. The finite element method is used to calculate the strain distribution, band alignment and confined levels of InPBi QDs. The carrier recombinations between the ground states and the deep levels are systematically investigated. A high Bi content and a flat QD shape are found preferable ...
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13. Multimodality Imaging Approach for Combined Central Retinal Vein and Artery Occlusion: The Role of Optical Coherence Tomography Angiography
  
  Explore Karger Publishers Dec 4 2019 Ophthalmology , Tunable Sources
  
  Combined central retinal artery and vein occlusion is an uncommon vascular pathology that can cause severe and permanent visual impairment. Optical coherence tomography angiography (OCTA) is a newly available, noninvasive imaging technique that can potentially improve understanding of the structural and vascular implications and prognosis of this infrequent pathology. The present report describes the principal clinical findings in a case of combined central retinal artery and vein occlusion, as detected by the different imaging modalities available in a tertiary referral hospital. OCTA wide-field montage images identified an extensive area of nonperfusion on the macula with involvement of the entire retina ...
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  Mentions: Topcon Medical Systems
14. Surface emitting laser, information obtaining apparatus, and imaging apparatus
  
  Explore uspto.gov Nov 26 2019 Patents , Tunable Sources
  
  The present invention provides a surface emitting laser the wavelength-tunable band of which is wide. The wavelength-tunable surface emitting laser includes a first reflector (101), an active layer (103) disposed on the first reflector (101), a beam portion (110) disposed over the active layer (103) with an air gap therebetween, and a second reflector (120) disposed on the beam portion (110). The second reflector (120) has a distributed Bragg reflector consisting of a stack of dielectric layers. The beam portion (110) has a distributed Bragg reflector consisting of a stack of conductive semiconductor layers.
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  Mentions: Canon Medical Systems
15. Method for signal processing in optical coherence tomography by means of a tunable light source
  
  Explore uspto.gov Nov 26 2019 Patents , Tunable Sources
  
  The invention relates to a method for signal processing in optical coherence tomography by means of a tunable light source (swept source), comprising the following steps: tuning the light source and sensing a signal intensity of the light source in linear dependence on the respective wave number (k) of the tunable light source and producing a signal intensity distribution in dependence on k; applying a window function to the sensed signal intensity distribution and producing a weighted signal intensity distribution; and applying a fast Fourier transform (FFT) to the weighted signal intensity distribution; and characterized in that, in the tuning ...
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  Mentions: Heidelberg Engineering
16. Thorlabs Extends MEMS-VCSEL Swept-Wavelength Laser Source Offering to Include 1060 nm
  
  Explore Optical Coherence Tomography News Nov 8 2019 Other Business News , Tunable Sources
  
  Thorlabs announced today that it has released next-generation versions of its MEMS-VCSEL Swept-Wavelength Laser Sources. The new SL10 series, centered at 1060 nm, complements the already well-established SL13 series at 1300 nm and is available with four different sweep rates ranging from 60 kHz to 400 kHz. Based on a patented microelectromechanical system (MEMS) tunable vertical cavity surface emitting laser (VCSEL), these light sources feature a record-breaking coherence length of over 100 mm and include an active power control that maintains constant output power over the lifetime of the laser. All drive electronics and trigger signals needed to seamlessly integrate ...
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  Mentions: Thorlabs
17. Acousto-optically tuned external-cavity laser diode for optical coherence tomography with continuous wavelet transform
  
  Explore SPIE Digital Library Oct 30 2019 Tunable Sources
  
  We propose an acousto-optically tuned external-cavity laser diode (ECLD) based on the Littrow configuration to expand the wavelength-scanning range and eliminate mechanical motions. The scanning range and tuning rate of our prototype were 68.85 nm and more than 100 kHz, respectively, without any mode hop. Moreover, we implemented this improved ECLD in an optical coherence tomography imaging system and conducted a measurement of the two-dimensional thickness distribution of a thin glass plate via continuous wavelet transform analysis.
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18. Highly-stable, multi-megahertz circular-ranging optical coherence tomography at 1.3 µm based on a chirped fiber Bragg grating
  
  Explore arxiv.org Oct 26 2019 Tunable Sources
  
  In Fourier-domain optical coherence tomography (OCT), the finite bandwidth of the acquisition electronics constrains the depth range and speed of the system. Circular-ranging (CR) OCT methods use optical-domain compression to surpass this limit. However, the CR-OCT system architectures of prior reports were limited by poor stability and were confined to the 1.55 µm wavelength range. In this work, we describe a novel CR-OCT architecture that is free from these limitations. To ensure stable operation, temperature sensitive optical modules within the system were replaced; the kilometer-length fiber spools used in the stretched-pulse mode-locked (SPML) laser was eliminated in favor of ...
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  Mentions: Brett E. Bouma Massachusetts General Hospital Harvard University
19. Marie Curie PhD Studentship: VCSELs for Optical Coherence Tomography
  
  Explore EURAXESS Oct 8 2019 Tunable Sources , Jobs & Studentships
  
  Two Marie Curie Early Stage Researcher/PhD positions for 36 months starting from 1st February and 1st of April 2020, respectively, are available within the Institute for Microwave Engineering and Photonics (Photonics group/ Terahertz Devices and Systems group). These are supported by an EU funded Marie Curie Innovative Training Network, 860807, jointly organised with 14 other universities, companies and hospitals in Europe. Students will spend most of their time in Darmstadt, Germany with secondments to at least one University and one industrial partner each. Research will focus on innovative solutions for swept sources for optical coherence tomography based on widely ...
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  Mentions: Université Pierre et Marie Curie
20. Wavelength tunable laser device
  
  Explore uspto.gov Sep 24 2019 Patents , Tunable Sources
  
  A photonic integrated circuit wavelength tunable laser device includes a gain element integrated into a photonic integrated circuit. The gain element provides optical gain to an optical signal. A tunable filter is integrated into the photonic integrated circuit. A modulator is integrated into the photonic integrated circuit that modulates the optical signal as a function of time, wherein the gain element, the tunable filter, and the modulator form a wavelength tunable laser device having a wavelength that tunes as a function of time.
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  Mentions: Eric A. Swanson
21. Surface emitting laser, information acquiring apparatus, imaging apparatus, laser array, and method of manufacturing surface emitting laser
  
  Explore uspto.gov Sep 17 2019 Patents , Tunable Sources
  
  A surface emitting laser having a wide wavelength tunable band is provided. A surface emitting laser includes a first reflecting mirror (102); a second reflecting mirror (116); and an active layer (104) arranged between the first reflecting mirror (102) and the second reflecting mirror (116), a gap being formed between the second reflecting mirror (116) and the active layer (104), an oscillation wavelength being tunable. The second reflecting mirror (116) includes a beam (108) comprising a single-crystal semiconductor, and a dielectric multilayer film (110) supported by the beam (108), and the dielectric multilayer film (110) is arranged in an opening ...
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  Mentions: Canon Medical Systems
22. Real time FPGA resampling for swept source optical coherence tomography
  
  Explore uspto.gov Aug 27 2019 Patents , Tunable Sources
  
  Real-time swept source OCT data is most often sampled using a specially cut hardware k-clock. The present invention involves mathematically resampling signals within an FPGA-based data acquisition board based on data sampled from a wide free spectral range reference interferometer. The FPGA can then multiply up the reference clock rate to achieve greater imaging depth. The Nyquist fold-over depth can thus be programmed from a standard reference to an arbitrary depth, much as PLL frequency synthesizer can produce many frequencies from a standard stable reference. The system is also capable of real-time performance.
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  Mentions: Axsun Technologies Brian D. Goldberg Bart Johnson
23. Laser swept source with controlled mode locking for OCT medical imaging
  
  Explore uspto.gov Aug 6 2019 Patents , Tunable Sources
  
  An optical coherence analysis system uses a laser swept source that is constrained to operate in a mode locked condition. This is accomplished by synchronously changing the laser cavity's gain and/or phase based on the round trip travel time of light in the cavity. Many high-speed wavelength swept laser sources emit pulses synchronized with the round trip time of the cavity as part of a nonlinear optical frequency red shifting process. Stable pulsation is associated with smooth tuning and low relative intensity noise. Addition of mode-locking methods to this class of lasers can control and stabilize these lasers ...
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  Mentions: Axsun Technologies Dale Flanders Bart Johnson
24. Praevium Research Inc Receives a 2019 NIH Grant for $497,982 for Manufacturable and Reliable Electrically-Pumped Micro-Electromechanically Tunable VCSELs for Low-Cost Ophthalmic SS-OCT
  
  Explore Optical Coherence Tomography News Jul 23 2019 Funding , Tunable Sources
  
  Praevium Research Inc Receives a 2019 NIH Grant for $497,982 for Manufacturable and Reliable Electrically-Pumped Micro-Electromechanically Tunable Vertical Cavity Surface Emitting Lasers for Low-Cost Ophthalmic Swept Source Optical Coherence Tomography. The principal investigator is Christopher Burgner. The program began in 2012 and ends in 2020. Below is a summary of the proposed work. The ultimate goal of this effort is to bring advanced ophthalmic swept source optical coherence tomography (SS-OCT) imaging to low cost broadly accessible environments. SS-OCT is a powerful non-invasive diagnostic imaging modality, and an increasingly valuable tool in the early detection and monitoring of a number ...
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  Mentions: National Institutes of Health Praevium Research
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